Masao Yoshizumi

Last Updated :2019/12/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), ., Professor
E-mail
yos1956oktbhhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, The University of Tokyo

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Cardiovascular medicine

Research Keywords

  • biomedical engineering
  • molecular biology
  • vascular biology
  • Cardiovascular Diseases
  • atherosclerosis

Educational Activity

Course in Charge

  1. 2019, Liberal Arts Education Program1, 2Term, Cell Science
  2. 2019, Undergraduate Education, Year, Physiology and Biochemistry
  3. 2019, Undergraduate Education, Intensive, Clinical diagnosis and treatment I
  4. 2019, Undergraduate Education, Intensive, Practice for medical research
  5. 2019, Undergraduate Education, 2Term, Introduction for medical research
  6. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  7. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  8. 2019, Graduate Education (Master's Program) , First Semester, Special Course of Biomedical & Health Sciences
  9. 2019, Graduate Education (Master's Program) , First Semester, Special Course of Biomedical & Health Sciences
  10. 2019, Graduate Education (Master's Program) , First Semester, Special Course of Biomedical & Health Sciences
  11. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  12. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  13. 2019, Graduate Education (Master's Program) , First Semester, Special Course of Biomedical & Health Sciences
  14. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  15. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  16. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  17. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  18. 2019, Graduate Education (Master's Program) , First Semester, Physiology and biological chemistry
  19. 2019, Graduate Education (Master's Program) , First Semester, Seminar on Cardiovascular Physiology and Medicine
  20. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on Cardiovascular Physiology and Medicine
  21. 2019, Graduate Education (Master's Program) , First Semester, Research on Cardiovascular Physiology and Medicine
  22. 2019, Graduate Education (Master's Program) , Second Semester, Research on Cardiovascular Physiology and Medicine
  23. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Cardiovascular Physiology and Medicine
  24. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Cardiovascular Physiology and Medicine
  25. 2019, Graduate Education (Master's Program) , First Semester, Research
  26. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced research on Cardiovascular Physiology and Medicine
  27. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Cardiovascular Physiology and Medicine
  28. 2019, Graduate Education (Master's Program) , First Semester, Seminar
  29. 2019, Graduate Education (Master's Program) , Second Semester, Seminar
  30. 2019, Graduate Education (Master's Program) , Second Semester, Research
  31. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  32. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  33. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  34. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  35. 2019, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry
  36. 2019, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  37. 2019, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  38. 2019, Graduate Education (Master's Program) , 1Term, Biomedical Sciences

Research Activities

Academic Papers

  1. Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms, PLOS ONE, 11(1), 20160119
  2. EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4, PLOS ONE, 11(10), 20161020
  3. Model-Based Evaluation of Reactive Hyperemia Using Strain-Gauge Plethysmography and Log-Linearized Viscoelastic Indices, JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 5(4), 334-341, 201504
  4. Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75 years among 4014 type 2 diabetic individuals, INTERNATIONAL JOURNAL OF CARDIOLOGY, 177(3), 860-866, 20141220
  5. Role of DNA Damage in Cardiovascular Disease, CIRCULATION JOURNAL, 78(1), 42-50, 201401
  6. Smoking Cessation Reverses DNA Double-Strand Breaks in Human Mononuclear Cells, PLOS ONE, 9(8), 20140805
  7. Hesr2 Knockout Mice Develop Aortic Valve Disease With Advancing Age, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(3), E84-+, 201303
  8. Cross-Talk of Receptor Activator of Nuclear Factor-kappa B Ligand Signaling With Renin-Angiotensin System in Vascular Calcification, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(6), 1287-+, 201306
  9. Acute effects of a sarin-like organophosphorus agent, bis(isopropyl methyl)phosphonate, on cardiovascular parameters in anaesthetized, artificially ventilated rats, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(1), 61-66, 20131001
  10. Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms., Hiroshima Journal of Medical Sciences, 62(3), 63-67, 20130901
  11. Monitoring of peripheral vascular condition using a log-linearized arterial viscoelastic index during endoscopic thoracic sympathectomy., Conf Proc IEEE Eng Med Biol Soc., 2587, 20130701
  12. A log-linearized arterial viscoelastic model for evaluation of the carotid artery., Conf Proc IEEE Eng Med Biol Soc, 2013, 2591-2594, 20130701
  13. Monitoring of peripheral vascular condition using a log-linearized arterial viscoelastic index during endoscopic thoracic sympathectomy, Conf Proc IEEE Eng Med Biol Soc, 2013, 2587-2590, 20130701
  14. Estimation of arterial viscoelastic variations using an electromagnetic induction-based carotid pulse pressure sensor., Journal of latex class files, 11, 20120401
  15. Novel non-invasive method of measurement of endothelial function: enclosed-zone flow-mediated dilatation (ezFMD), MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 50(12), 1239-1247, 201212
  16. Circadian variation of blood pressure and endothelial function in patients with essential hypertension:a comparison of dippers and non-dippers., Circadian variation of blood pressure and endothelial function in patients with essential hypertension:a comparison of dippers and non-dippers., 40(11), 2002
  17. Smoking activates rho-kinase in smooth muscle cells of forearm vasculature in humans., Smoking activates rho-kinase in smooth muscle cells of forearm vasculature in humans., 41(5), 2003
  18. Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients., Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients., 51(2), 2008
  19. Angiotensin (1-7), small but complicated, needs more exercise., Angiotensin (1-7), small but complicated, needs more exercise., 79(6), 2015
  20. Role of DNA damage in cardiovascular disease., Role of DNA damage in cardiovascular disease., 78(1), 2014
  21. Myocardial protection against pressure overload in mice lacking Bach1, a transcriptional repressor of heme oxygenase-1., Myocardial protection against pressure overload in mice lacking Bach1, a transcriptional repressor of heme oxygenase-1., 51(6), 2008
  22. Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms., Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms., 62(3), 2013
  23. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases., Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases., 1(1), 2006
  24. Change in bilirubin level following acute myocardial infarction is an index for heme oxygenase activation., Change in bilirubin level following acute myocardial infarction is an index for heme oxygenase activation., 103(9), 2010
  25. A novel online method to monitor autonomic nervous activity based on arterial wall impedance and heart rate variability., A novel online method to monitor autonomic nervous activity based on arterial wall impedance and heart rate variability., 48(4), 2010
  26. Nifedipine interferes with migration of vascular smooth muscle cells via inhibition of Pyk2-Src axis., Nifedipine interferes with migration of vascular smooth muscle cells via inhibition of Pyk2-Src axis., 16(3), 2009
  27. Cigarette smoking abolishes ischemic preconditioning-induced augmentation of endothelium-dependent vasodilation., Cigarette smoking abolishes ischemic preconditioning-induced augmentation of endothelium-dependent vasodilation., 53(4), 2009
  28. Endothelial function and oxidative stress in cardiovascular diseases., Endothelial function and oxidative stress in cardiovascular diseases., 73(3), 2009
  29. Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells., Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells., 68(2), 2005
  30. Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production., Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production., 186(2), 2006
  31. Adrenomedullin causes coronary vasodilation in humans: effects of inhibition of nitric oxide synthesis., Adrenomedullin causes coronary vasodilation in humans: effects of inhibition of nitric oxide synthesis., 46(4), 2005
  32. Smoking, endothelial function, and Rho-kinase in humans., Smoking, endothelial function, and Rho-kinase in humans., 25(12), 2005
  33. Relationship between endothelial function in the coronary and brachial arteries., Relationship between endothelial function in the coronary and brachial arteries., 28(10), 2005
  34. Induction of heme oxygenase-1 inhibits monocyte chemoattractant protein-1 mRNA expression in U937 cells., Induction of heme oxygenase-1 inhibits monocyte chemoattractant protein-1 mRNA expression in U937 cells., 100(2), 2006
  35. Heme oxygenase-1 gene enhancer manifests silencing activity in a chromatin environment prior to oxidative stress., Heme oxygenase-1 gene enhancer manifests silencing activity in a chromatin environment prior to oxidative stress., 8(1-2)
  36. Beneficial effect of T-type calcium channel blockers on endothelial function in patients with essential hypertension., Beneficial effect of T-type calcium channel blockers on endothelial function in patients with essential hypertension., 28(11), 2005
  37. Genetic ablation of the transcription repressor Bach1 leads to myocardial protection against ischemia/reperfusion in mice., Genetic ablation of the transcription repressor Bach1 leads to myocardial protection against ischemia/reperfusion in mice., 11(7), 2006
  38. Effects of acute administration of caffeine on vascular function., Effects of acute administration of caffeine on vascular function., 98(11), 2006
  39. Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness., Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness., 49(6), 2007
  40. Images in cardiovascular medicine. Corkscrew collaterals in thromboangitis obliterans (Buerger's disease)., Images in cardiovascular medicine. Corkscrew collaterals in thromboangitis obliterans (Buerger's disease)., 116(21), 2007
  41. AT2 receptor mediates the cardioprotective effects of AT1 receptor antagonist in post-myocardial infarction remodeling., AT2 receptor mediates the cardioprotective effects of AT1 receptor antagonist in post-myocardial infarction remodeling., 80(1), 2006
  42. PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers., PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers., 41(5), 2003
  43. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress., Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress., 108(5), 2003
  44. Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress., Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress., 42(2), 2003
  45. [Endothelial function]., [Endothelial function]., 61(7), 2003
  46. Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats., Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats., 310(3), 2003
  47. Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells., Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells., 93(12), 2003
  48. Response of the left anterior descending coronary artery to acetylcholine in patients with chest pain and angiographically normal coronary arteries., Response of the left anterior descending coronary artery to acetylcholine in patients with chest pain and angiographically normal coronary arteries., 92(12), 2003
  49. [Oxidative stress, reactive oxygen species]., [Oxidative stress, reactive oxygen species]., 62(1), 2004
  50. Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation., Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation., 43(5), 2004
  51. Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia., Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia., 109(10), 2004
  52. Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients., Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients., 102(1), 2004
  53. Tooth loss is associated with an increased risk of hypertension in postmenopausal women., Tooth loss is associated with an increased risk of hypertension in postmenopausal women., 43(6), 2004
  54. Forearm endothelial function and bone mineral loss in postmenopausal women., Forearm endothelial function and bone mineral loss in postmenopausal women., 176(2), 2004
  55. Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers., Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers., 94(8), 2004
  56. [Asymmetric dimethylarginine and endothelial dysfunction]., [Asymmetric dimethylarginine and endothelial dysfunction]., 62 Suppl 9, 2004
  57. Apolipoprotein E phenotype affects the malondialdehyde-modified LDL concentration and forearm endothelial function in postmenopausal women., Apolipoprotein E phenotype affects the malondialdehyde-modified LDL concentration and forearm endothelial function in postmenopausal women., 61(5), 2004
  58. Vascular function in patients with lower extremity peripheral arterial disease: a comparison of functions in upper and lower extremities., Vascular function in patients with lower extremity peripheral arterial disease: a comparison of functions in upper and lower extremities., 178(1), 2005
  59. The nicorandil-induced vasodilation in humans is inhibited by miconazole., The nicorandil-induced vasodilation in humans is inhibited by miconazole., 45(4), 2005
  60. Association of Helicobacter pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects., Association of Helicobacter pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects., 45(8), 2005
  61. Angiotensin II type I receptor blocker and endothelial function in humans: role of nitric oxide and oxidative stress., Angiotensin II type I receptor blocker and endothelial function in humans: role of nitric oxide and oxidative stress., 3(2), 2005
  62. Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle, NATURE COMMUNICATIONS, 8, 20170313
  63. The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(8), 201708
  64. Oxidative stress, endothelial function and angiogenesis induced by cell therapy and gene therapy., Oxidative stress, endothelial function and angiogenesis induced by cell therapy and gene therapy., 7(2), 2006
  65. Interaction of obesity and skeletal bone mineral density in tooth retention in Japanese postmenopausal women., Interaction of obesity and skeletal bone mineral density in tooth retention in Japanese postmenopausal women., 14(3 Pt 1)
  66. Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease., Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease., 49(4), 2007
  67. Repetition of ischemic preconditioning augments endothelium-dependent vasodilation in humans: role of endothelium-derived nitric oxide and endothelial progenitor cells., Repetition of ischemic preconditioning augments endothelium-dependent vasodilation in humans: role of endothelium-derived nitric oxide and endothelial progenitor cells., 27(6), 2007
  68. Measurement of flow-mediated vasodilation of the brachial artery: a comparison of measurements in the seated and supine positions., Measurement of flow-mediated vasodilation of the brachial artery: a comparison of measurements in the seated and supine positions., 71(5), 2007
  69. Role of osteoprotegerin in arterial calcification: development of new animal model., Role of osteoprotegerin in arterial calcification: development of new animal model., 27(9), 2007
  70. Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans., Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans., 30(9), 2007
  71. Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells, PLOS ONE, 12(11), NOV 9 2017
  72. Protective Effects of Japanese Soybean Paste (Miso) on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP), AMERICAN JOURNAL OF HYPERTENSION, 31(1), 43-47, Dec 8
  73. Quantitative Evaluation of Pain during Electrocutaneous Stimulation using a Log-Linearized Peripheral Arterial Viscoelastic Model, SCIENTIFIC REPORTS, 8, FEB 15 2018
  74. A new arterial mechanical property indicator reflecting differences in invasive stimulus intensity induced by alteration of remifentanil concentration during laryngoscopy, MINERVA ANESTESIOLOGICA, 84(3), 311-318, MAR 2018
  75. XRCC3 polymorphism is associated with hypertension-induced left ventricular hypertrophy, HYPERTENSION RESEARCH, 41(6), 426-434, JUN 2018
  76. Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation, SCIENTIFIC REPORTS, 8, JUN 18 2018
  77. Estimation of Arterial Viscosity Based on an Oscillometric Method and Its Application in Evaluating the Vascular Endothelial Function, SCIENTIFIC REPORTS, 9, 20190222

Invited Lecture, Oral Presentation, Poster Presentation

  1. XRCC3 Polymorphism and hypertension-induced left ventricle hypertrophy., Andi Ariyandy, Chiemi Sakai, Mari Ishida, Masao Yoshizumi, Satoshi Tashiro, Kiyoshi Miyagawa and Takafumi Ishida., 2017/02/22, Without Invitation
  2. XRCC3 polymorphism is associated with hypertension-induced left ventricular hypertrophy., Chiemi Sakai, Mari Ishida, Andi Ariyandy, Takamasa Mizuta, Keitaro Ueda, Masao Yoshizumi , Takafumi Ishida, The 81th Annual Scientific Meeting of the Japanese Circulation Society., 2017/03/17, Without Invitation
  3. Role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-osteoprotegerin (OPG) axis in the development of abdominal aortic aneurysm., Bumdelger Batmunkh, Hiroki Kokubo, Ryo Kamata, Masayuki Fujii, Takafumi Ishida, Mari Ishida, Koichi Yoshimura, Masao Yoshizumi., 2017/07/06, Without Invitation
  4. Role of XRCC3 in cardiac hypertrophy., Chiemi Sakai, Mari Ishida, Andi Ariyandy, Takamasa Mizuta, Kiyoshi Miyagawa, Satoshi Tashiro, Masao Yoshizumi, Takafumi Ishida.東京 , The 1st JCS Council Forum on Basic Cardiovascular Reserch., 2018/01/06, Without Invitation, Tokyo
  5. Identification of cardiac progenitors for the outflow tract, the left ventricle, atria, and the sinus venosus., Masayuki Fujii, Akane Sakaguchi, Masao Yoshizumi, Yumiko Saga, and Hiroki Kokubo, 2017/03/18, Without Invitation
  6. EPA attenuates the progression of Abdominal Aortic Aneurysms., Ryo Kamata, Hiroki Kokubo, Batmunkh Bumdelger, and Masao Yoshizumi, 2017/03/18, Without Invitation
  7. Identification of cardiac progenitors for all myocardial structures except for the right ventricle., Masayuki Fujii, Akane Sakaguchi, Masao Yoshizumi, Yumiko Saga, and Hiroki Kokubo, 2017/03/28, Without Invitation
  8. Identification of cardiac progenitors for the outflow tract, the left ventricle, the atria, and the sinus venous., Hiroki Kokubo, Masayuki Fujii, Akane Sakaguchi, Masao Yoshizumi, Yumiko Saga, 2017/12/07, Without Invitation