Yoshio Yaoita

Last Updated :2018/11/01

Affiliations, Positions
Institute for Amphibian Biology, Institute for Amphibian Biology, Professor
E-mail
yaoitahiroshima-u.ac.jp
Other Contact Details
1-3-1,Kagamiyama,Higashi-Hiroshima, Japan
TEL : (+81)824-24-7481 FAX : (+81)824-24-0739
Self-introduction
Developmental Biology, Amphibia, Metamorphosis

Basic Information

Major Professional Backgrounds

  • 2000/09/01, 2016/09/30, Hiroshima University, Professor
  • 1983/10/01, 1985/03/31, Osaka University, Assistant Professor
  • 1987/06/16, 1990/06/08, Carnegie Institution of Washington, Research Assistant
  • 1985/04/01, 1990/06/30, Kyoto University, Assistant Professor
  • 1990/07/01, 2000/08/31, Tokyo Metropolitan Institute for Neuroscience, Head Researcher

Educational Backgrounds

  • Osaka University, Graduate School, Division of Medicine, Japan, 1979/04, 1983/03
  • The University of Tokyo, Faculty of Medicine, Japan, 1973/04, 1979/03

Academic Degrees

  • M. D. and Ph. D., Osaka University

Research Fields

  • Biology;Biological Science;Functional biochemistry

Research Keywords

  • metamorphosis
  • apoptosis
  • programmed cell death
  • Xenopus

Affiliated Academic Societies

  • the Zoological Society of Japan
  • The Japanese Biochemical Socity
  • The Moleclar Biology Society of Japan
  • The Japanese Society of Developmental Biologists

Educational Activity

Course in Charge

  1. 2018, Liberal Arts Education Program1, 1Term, Fundamentals of Biology
  2. 2018, Liberal Arts Education Program1, 4Term, Introduction to Biology
  3. 2018, Liberal Arts Education Program1, 3Term, Life System through Frog Research
  4. 2018, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  5. 2018, Undergraduate Education, 2Term, Advanced Biology
  6. 2018, Undergraduate Education, 2Term, Basic Biological Science B
  7. 2018, Undergraduate Education, First Semester, Special Study for Graduation
  8. 2018, Undergraduate Education, Second Semester, Special Study for Graduation
  9. 2018, Undergraduate Education, 1Term, Endocrinology・Immunology
  10. 2018, Undergraduate Education, Second Semester, Seminar for amphibian biology
  11. 2018, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  12. 2018, Graduate Education (Master's Program) , First Semester, Special Research for Thesis
  13. 2018, Graduate Education (Master's Program) , Second Semester, Special Research for Thesis
  14. 2018, Graduate Education (Master's Program) , First Semester, Morphogenesis
  15. 2018, Graduate Education (Master's Program) , First Semester, Seminar of Amphibian Embryology
  16. 2018, Graduate Education (Master's Program) , Second Semester, Seminar of Amphibian Embryology
  17. 2018, Graduate Education (Doctoral Program) , First Semester, Special Research for Biological Science
  18. 2018, Graduate Education (Doctoral Program) , Second Semester, Special Research for Biological Science

Research Activities

Academic Papers

  1. Expression of matrix metalloproteinase genes in regressing or remodeling organs during amphibian metamorphosis, DEVELOPMENT GROWTH & DIFFERENTIATION, 49(2), 131-143, 200702
  2. Expression profiles of the duplicated matrix metalloproteinase-9 genes suggest their different poles in apoptosis of larval intestinal epithelial cells during Xenopus laevis metamorphosis, DEVELOPMENTAL DYNAMICS, 236(8), 2338-2345, 200708
  3. Translational regulation by the 5 '-UTR of thyroid hormone receptor alpha mRNA, JOURNAL OF BIOCHEMISTRY, 151(5), 519-531, 201205
  4. Regulation of thyroid hormone sensitivity by differential expression of the thyroid hormone receptor during Xenopus metamorphosis, GENES TO CELLS, 17(8), 645-659, 201208
  5. Generation of albino Xenopus tropicalis using zinc-finger nucleases, DEVELOPMENT GROWTH & DIFFERENTIATION, 54(9), 777-784, 201212
  6. Expression of the amelogenin Gene in the Skin of Xenopus tropicalis, ZOOLOGICAL SCIENCE, 30(3), 154-159, 201303
  7. Targeted Gene Disruption in the Xenopus tropicalis Genome Using Designed TALE Nucleases, ZOOLOGICAL SCIENCE, 30(6), 455-460, 201306
  8. The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity., Genes to Cells, 9, 1249-1264, 20040401
  9. Involvement of caspase-9 in execution of the maternal program of apoptosis in Xenopus late blastulae overexpressed with S-ademosylmethionine decarbosylase, Biochemical and Biophysical Research Communications, 325(4), 1367-1375, 20041201
  10. Programmed Cell Death during Amphibian Metamorphosis, 16, 271-280, 20050401
  11. Comparison of TALEN scaffolds in Xenopus tropicalis, BIOLOGY OPEN, 2, 1364-1370, 2013
  12. Inhibition of Nuclear Transport of Caspase-7 by its Prodomain, Biochemical and Biophysical Research Communications, 291, 79-84, 20020201
  13. Structure, Expression and Function of the Xenopus laevis Caspase Family, Journal of Biological Chemistry, 275(14), 10484-10491, 20000401
  14. Maternal program of apoptosis activated shortly after midblastula transition by overexpression of S-adenosylmethionine decarboxylase in Xenopus early embryos, Comparative Biochemistry and Physiology part A, 126(2), 149-155, 20000601
  15. Construction of multiple-epitope tag sequence by PCR for sensitive Western blot analysis, Nucleic Acids Research, 25(11), 2231-2232, 19970601
  16. Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail, Journal of Biological Chemistry, 272(8), 5122-5127, 19970201
  17. Genomic organization and alternative promoter usage of the two thyroid hormone recepter beta genes in Xenopus laevis, Journal of Biological Chemistry, 267, 733-738, 19920401
  18. A correlation of thyroid hormone receptor gene expression with amphibian metamorphosis, Genes and Development, 4, 1917-1924, 19900401
  19. Xenopus laevis alpha and beta thyroid hormone receptors, Proceedings of the National Academy of Sciences of the USA, 87, 7090-7094, 19900401
  20. Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice, Journal of Biochemistry, 104, 337-343, 19880401
  21. Human neoplastic B cells express more than two isotypes of immunoglobulins without deletion of heavy-chain constant region genes, Genes and Development, 1, 465-470, 19870401
  22. Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B cell growth factor II, Proceedings of the National Academy of Sciences of the USA, 84, 4581-4585, 19870401
  23. The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts, Journal of Biological Chemistry, 262, 5079-5086, 19870401
  24. Molecular characterization of novel reciprocal translocation t(6;14) in an Epstein-Barr virus-transformed B cell precursor, Molecular Cellular Biology, 7, 708-717, 19870401
  25. Nucleotide sequences of immunoglobulin epsilon genes of chimpanzee and orangutan, DNA molecular clock and hominoid evolution, Proceedings of the National Academy of Sciences of the USA, 84, 1080-1084, 19870401
  26. Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue, Nucleic Acids Research, 14, 9149-9158, 19860401
  27. Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II, Nature, 324, 70-73, 19860401
  28. Interleukin 1-alpha mRNA in virus-transformed T and B cells, Biochemical and Biophysical Reseach Communications, 139, 353-360, 19860401
  29. Preferential transcription of HTLV-I LTR in cell-free extracts of human T cells producing HTLV-I viral proteins, Nucleic Acids Research, 14, 4779-4786, 19860401
  30. Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter, Nature, 319, 640-646, 19860401
  31. Immunoglobulin gene organization of UV-illuminated human lymphoblastoid cell lines producing both IgM and IgG, Mol. Bio. Med., 2, 335-337, 19840401
  32. The D-JH complex is an intermediate to the complete immunoglobulin heavy-chain V-region gene, Nucleic Acids Research, 11, 7303-7316, 19830401
  33. A T15-idiotype-positive T suppressor hybridoma does not use the T15 VH gene segment, Proceedings of the National Academy of Sciences of the USA, 79, 6984-6988, 19820401
  34. Immunoglobulin switch region-like sequences in Drosophila melanogaster, Nucleic Acids Research, 10, 4203-4214, 19820401
  35. Reconstitution of antigen-specific suppressor activity with translation products of mRNA, Nature, 298, 172-174, 19820401
  36. Expression of lymphocyte surface IgE does not require switch recombination, Nature, 297(5868), 697-700, 19820101
  37. Organization of the constant-region gene family of the mouse immunoglobulin heavy chain, Cell, 28, 499-506, 19820401
  38. Japanese wild mouse, Mus musculus molossinus has duplicated immunoglobulin gamma 2a genes, Nature, 298, 82-84, 19820401
  39. Rearrangements of immunoglobulin genes during differentiation and evolution, Immunological Reviews, 59, 33-67, 19810401
  40. Organization and reorganization of immunoglobulin heavy-chain genes, Cold Spring Harbor Symp.Quant. Biol., 45, 913-923, 19810401
  41. Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome, Nature, 286, 850-853, 19800401
  42. Deletion of immunoglobulin heavy chain genes accompanies the class switch rearrangement, Biomedical Research, 1, 164-175, 19800401
  43. One of the duplicated matrix metalloproteinase-9 genes is expressed in regressing tail during anuran metamorphosis, Development Growth & Differentiation, 48(4), 223-241, 20060501
  44. Occurrence of pre-MBT synthesis of caspase-8 mRNA and activation of caspase-8 prior to execution of SAMDC (S-adenosylmethionine decarboxylase)-induced, but not p53-induced, apoptosis in Xenopus late of blastulae., Biochem. Biophys. Res. Commun., 336, 682-691, 20050901
  45. Xenopus tropicalis: An Ideal Experimental Animal in Amphibia, Experimental Animals, 59(4), 395, 20100701
  46. Dual mechanisms governing muscle cell death in tadpole tail during amphibian metamorphosis, DEVELOPMENTAL DYNAMICS, 227(2), 246-255, JUN 2003
  47. Identification of transcriptional regulatory elements in the human somatostatin receptor sst2 promoter and regions including estrogen response element half-site for estrogen activation, JOURNAL OF MOLECULAR ENDOCRINOLOGY, 40(1-2), 75-91, JAN-FEB 2008
  48. Tumor necrosis factor-alpha attenuates thyroid hormone-induced apoptosis in vascular endothelial cell line XLgoo established from Xenopus tadpole tails, ENDOCRINOLOGY, 149(7), 3379-3389, JUL 2008
  49. NBRP databases: databases of biological resources in Japan, NUCLEIC ACIDS RESEARCH, 38, D26-D32, JAN 2010
  50. Highly efficient gene knockout by injection of TALEN mRNAs into oocytes and host transfer in Xenopus laevis, BIOLOGY OPEN, 4(2), 180-185, FEB 15 2015
  51. Development of a new approach for targeted gene editing in primordial germ cells using TALENs in Xenopus, BIOLOGY OPEN, 4(3), 259-266, MAR 15 2015
  52. MOLECULAR MECHANISM OF MUSCLE CELL DEATH IN A REGRESSING TAIL DURING AMPHIBIAN METAMORPHOSIS(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan), Zoological science, 20(12), 20031225
  53. Comparison of TALEN scaffolds in Xenopus tropicalis, BIOLOGY OPEN, 2(12), 1364-1370, DEC 15 2013
  54. Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients, DEVELOPMENTAL BIOLOGY, 408(2), 328-344, DEC 15 2015
  55. Characterization of myosin II regulatory light chain isoforms in HeLa cells, CYTOSKELETON, 72(12), 609-620, DEC 2015
  56. Ouro proteins are not essential to tail regression during Xenopus tropicalis metamorphosis, GENES TO CELLS, 21(3), 275-286, MAR 2016
  57. Generation of Albino Cynops pyrrhogaster by Genomic Editingof the tyrosinase Gene, ZOOLOGICAL SCIENCE, 33(3), 290-294, JUN 2016
  58. An Inhibitor of Thyroid Hormone Synthesis Protects Tail Skin Grafts Transplanted to Syngenic Adult Frogs, ZOOLOGICAL SCIENCE, 34(5), 414-418, OCT 2017
  59. Vitamin A induced homeotic hindlimb formation on dorsal and ventral sides of regenerating tissue of amputated tails of Japanese brown frog tadpoles, DEVELOPMENT GROWTH & DIFFERENTIATION, 59(9), 688-700, DEC 2017
  60. Thyroid Hormone Receptor alpha- and beta-Knockout Xenopus tropicalis Tadpoles Reveal Subtype-Specific Roles During Development, ENDOCRINOLOGY, 159(2), 733-743, FEB 2018
  61. no privacy, a Xenopus tropicalis mutant, is a model of human Hermansky-Pudlak Syndrome and allows visualization of internal organogenesis during tadpole development, DEVELOPMENTAL BIOLOGY, 426(2), 472-486, JUN 15 2017

Publications such as books

  1. 1996/11, 変態とアポトーシス , 羊土社, 1996, 11, 2
  2. 1998/10, 両生類の変態とアポトーシス , 医歯薬出版株式会社, 1998, 10, 6
  3. 1989, Contstant region genes of the immunoglobulin heavy chain and molecular mechanism of class switching , Harcourt Brace Jovanovich Publishers, 1989
  4. 1987, IgG1 induction factor: A single molecular entity with multiple biological functions. Mechanisms of Lymphocyte Activation and Immune Regulation., Plenum Publishing Corporation, 1987
  5. 1984, RNA splicing may be involved in a stimultaneous production of two isotypes , Alan R. Liss= Inc. New York, 1984
  6. 1983, Organization and reorganization of constant region genes of immunoglobulin heavy chain , Plenum Publishing Corporation, 1983
  7. 1982, Organization of immunoglobulin heavy chain genes and genetic mechanism for class switch , Raven Press= New York, 1982
  8. 1981, Organization of immunoglobulin heavy chain genes and genetic mechanism in class switch , Academic Press= New York=, 1981
  9. 1998, 両生類の変態とアポトーシス , ISHIYAKU PUBLISHERS= INC., 1998
  10. 1996, 変態とアポトーシス , 1996
  11. 1995, プローブDNAの調整法 , Nankoudo, 1995
  12. 1995, プローブDNAの標識 , Nankoudo, 1995
  13. 1993, 変態に伴うオタマジャクシの尾での細胞死 , 1993
  14. 1993, 変態と細胞死 , 北隆館, 1993
  15. 1992, 変態と甲状腺ホルモンレセプター遺伝子発現 , 1992
  16. 1989, インターロイキン4,5とそのレセプター , MARUZEN, 1989
  17. 1987, B細胞増殖因子遺伝子の構造と機能 , Kyoritsu Shuppan Co. = LTD, 1987
  18. 1987, B細胞増殖因子の遺伝子クローニング , 1987
  19. 1987, B細胞増殖・分化因子の遺伝子の構造とその活性 , Tokyou Kagaku Doujin, 1987
  20. 1986, 免疫 , Nankoudo, 1986
  21. 1984, 免疫グロブリン遺伝子の発現機構 , 科学評論者, 1984
  22. 1983, 免疫グロブリンのクラススイッチ , 科学評論者, 1983
  23. 1983, Southern Blotting , 1983
  24. 1987, Growth factors and receptors of lymphocytes , Acta Neurochirurgica= Supplement, 1987
  25. 1987, Structure and function of interleukins 4 snd 5. , Acta Paediatrica Japonica, 1987
  26. 2006, アフリカツメガエル、Resource of Xenopus、, 遺伝, 2006
  27. 2009, 両生類実験動物Xenopus tropicalisを中心として, 細胞工学別冊「バイオリソース&データベース活用術 webでキャッチ!!実験材料・インフォマティクス」, 2009
  28. 2012, 蛙や昆虫の変態について, 日本医事新報, 2012