Toru Hosoi

Last Updated :2019/02/01

Affiliations, Positions
Graduate School of Biomedical & Health Sciences (Medicinal Sciences Major), Associate Professor
E-mail
toruhhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, HOKKAIDO UNIVERSITY
  • Master of Pharmaceutical Science, HOKKAIDO UNIVERSITY

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2018, Liberal Arts Education Program1, 1Term, Foundation biology for life science
  2. 2018, Liberal Arts Education Program1, 1Term, Foundation biology for life science
  3. 2018, Undergraduate Education, 1Term, Pharmacotherapy A
  4. 2018, Undergraduate Education, 3Term, Clinical Pharmacology A
  5. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced Lecture on Creation and Development of Biomedical Sciences
  6. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced Lecture on Creation and Development of Biomedical Sciences
  7. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced Lecture on Creation and Development of Biomedical Sciences
  8. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced Lecture on pharmacotherpeutic research
  9. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced Lecture on pharmacotherpeutic research
  10. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced Lecture on pharmacotherpeutic research
  11. 2018, Graduate Education (Master's Program) , First Semester, Advanced lecture on medicinal science
  12. 2018, Graduate Education (Master's Program) , First Semester, Seminar on molecular pharmacotherapeutics
  13. 2018, Graduate Education (Master's Program) , Second Semester, Seminar on molecular pharmacotherapeutics
  14. 2018, Graduate Education (Doctoral Program) , First Semester, Advanced lecture on medicinal science
  15. 2018, Graduate Education (Doctoral Program) , First Semester, Advanced research on Pharmacotherapy
  16. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Pharmacotherapy
  17. 2018, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Pharmacotherapy
  18. 2018, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Pharmacotherapy

Research Activities

Academic Papers

  1. Expression of leptin receptors and induction of IL-1beta transcript in glial cells., Biochem. Biophys. Res. Commun., 273(1), 312-315, 20000601
  2. Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis., Am. J. Physiol., 279(1), R141-R147, 20000701
  3. Subdiaphragmatic vagotomy fails to inhibit intravenous leptin-induced IL-1beta expression in the hypothalamus., Am. J. Physiol., 282(2), R627-R631, 20020201
  4. Leptin induces IL-1 receptor antagonist expression in the brain., Biochem. Biophys. Res. Commun., 294(2), 215-219, 20020601
  5. The mechanisms of immune-to-brain communication in inflammation as a drug target., Curr Drug Targets Inflamm Allergy., 1(3), 257-262, 20020901
  6. Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms., Brain Res., 949(1-2), 139-146, 20020901
  7. The presence and functions of muscarinic receptors in human T cells: the involvement in IL-2 and IL-2 receptor system., Life Sci., 72(18-19), 2121-2126, 20030301
  8. Inhibition of leptin-induced IL-1beta expression by glucocorticoids in the brain., Brain Res., 969(1-2), 95-101, 20030401
  9. A beta-induced TNF-alpha expression and acetylcholine action in mouse glial cells., Life Sci., 72(18-19), 2117-2120, 20030301
  10. Cholecystokinin inhibits food intake independent of interleukin-1 beta expression in the brain., Biol. Pharm. Bull., 26(8), 1181-1183, 20030801
  11. Induction of murine HRD1 in experimental cerebral ischemia., Mol. Brain Res., 130(1-2), 30-38, 20041101
  12. Bacterial endotoxin induces STAT3 activation in the mouse brain., Brain Res., 1023(1), 48-53, 20041001
  13. Functional role of acetylcholine in the immune system., Front Biosci., 9(1), 2414-2419, 20040901
  14. Effect of subdiaphragmatic vagotomy on bacterial DNA-induced IL-1beta expression in the mouse hypothalamus., Brain Res., 1028(2), 233-237, 20041201
  15. Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction., J. Pharmacol. Exp. Ther., 311(1), 388-393, 20041001
  16. Sodium 4-phenylbutyrate protects against cerebral ischemic injury., Mol Pharmacol, 66(4), 899-908, 20041001
  17. Biochemical changes in the brain of senescence-accelerated mouse P8 and P10., International Congress Series, 1260, 91-97, 2004
  18. Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells., Mol. Brain Res., 124(2), 159-164, 20040501
  19. LPS induces stefin A3 expression in mouse primary cultured glial cells, MOLECULAR BRAIN RESEARCH, 140(1-2), 138-141, 20051031
  20. Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 28(8), 1514-1516, 200508
  21. STAT3 activation and c-FOS expression in the brain following peripheral administration of bacterial DNA., J. Neuroimmunol., 158(1-2), 40-49, 20050101
  22. Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion, AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 120(1-2), 104-107, 20050615
  23. 2-aminopurine inhibits leptin receptor signal transduction, EUROPEAN JOURNAL OF PHARMACOLOGY, 553(1-3), 61-66, 20061228
  24. Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress, JOURNAL OF NEUROCHEMISTRY, 97(5), 1259-1268, 200606
  25. PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 340(1), 286-290, 20060203
  26. Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17(2), 184-186, 20070201
  27. Akt up- and down-regulation in response to endoplasmic reticulum stress, BRAIN RESEARCH, 1152, 27-31, 20070604
  28. Vanadate inhibits endoplasmic reticulum stress responses, EUROPEAN JOURNAL OF PHARMACOLOGY, 594(1-3), 44-48, 20081010
  29. Endoplasmic Reticulum Stress Induces Leptin Resistance, MOLECULAR PHARMACOLOGY, 74(6), 1610-1619, 200812
  30. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells, NEUROCHEMISTRY INTERNATIONAL, 54(1), 1-6, 200901
  31. Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance., Journal of Medical Investigation, 56, 296-298, 2009
  32. Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities, CLINICAL SCIENCE, 118(1-2), 19-29, 201001
  33. A unique modulator of endoplasmic reticulum stress-signalling pathways: the novel pharmacological properties of amiloride in glial cells, BRITISH JOURNAL OF PHARMACOLOGY, 159(2), 428-437, 201001
  34. Homocysteine induces X-box-binding protein 1 splicing in the mice brain, NEUROCHEMISTRY INTERNATIONAL, 56(2), 216-220, 201001
  35. Potential Down-Regulation of Salivary Gland AQP5 by LPS via Cross-Coupling of NF-kappa B and p-c-Jun/c-Fos, AMERICAN JOURNAL OF PATHOLOGY, 177(2), 724-734, 201008
  36. Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice, PLOS ONE, 5(9), 20100902
  37. TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress, JOURNAL OF PHARMACOLOGICAL SCIENCES, 114(2), 230-233, 201010
  38. Novel Therapeutic Approach Based on Recent Understanding of the Development of Metabolic Syndrome, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 131(11), 1557-1562, 201111
  39. Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded proteinresponses in cultured glial cells., PLoS One, 7((6)), e40144, 20120601
  40. Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance., Front Endocrinol (Lausanne), 20120101
  41. Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(1), 84-90, 201201
  42. Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease: Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer's Disease, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118(3), 319-324, 201203
  43. Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice, GENE, 497(2), 340-343, 20120415
  44. Inhibition of Casein Kinase 2 Modulates XBP1-GRP78 Arm of Unfolded Protein Responses in Cultured Glial Cells, PLOS ONE, 7(6), 20120629
  45. ER stress-mediated regulation of immune function under glucose-deprived condition in glial cells: Up- and down-regulation of PGE(2) + IFN gamma-induced IL-6 and iNOS expressions, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441(2), 525-528, 20131115
  46. Tributyltin-induced endoplasmic reticulum stress and its Ca2+-mediated mechanism, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(1), 137-146, 20131001
  47. ER stress upregulated PGE(2)/IFN gamma-induced IL-6 expression and down-regulated iNOS expression in glial cells, SCIENTIFIC REPORTS, 3, 20131202
  48. Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress, EMBO MOLECULAR MEDICINE, 6(3), 335-346, 201403
  49. TERT attenuated ER stress-induced cell death, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 447(2), 378-382, 20140502
  50. Inhibition of inducible nitric oxide synthase and interleukin-1 beta expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide, BRAIN RESEARCH, 1558, 11-17, 20140416
  51. Caffeine attenuated ER stress-induced leptin resistance in neurons, NEUROSCIENCE LETTERS, 569, 23-26, 20140521
  52. Therapeutic potential of flurbiprofen against obesity in mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 449(1), 132-134, 20140620
  53. Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells, SCIENTIFIC REPORTS, 4, 20141118
  54. Stress-Induced Neuroprotective Effects of Epiregulin and Amphiregulin, PLOS ONE, 10(2), 20150212
  55. Possible involvement of 15-deoxy-Delta(12,14)-prostaglandin J(2) in the development of leptin resistance, JOURNAL OF NEUROCHEMISTRY, 133(3), 343-351, 201505
  56. Stress-induced neuroprotective effects of epiregulin and amphiregulin., PLOS One, 10, e0118280, 201502
  57. Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460, 628-632, 201505
  58. Implementation and Evaluation of Genetic Testing Seminars on Lifestyle-related Disease Prevention for Pharmacy Students, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136(2), 337-350, 201602
  59. The Mechanisms and Pharmacological Strategy for Treatment of ER Stress-induced Metabolic Syndrome, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136(6), 827-830, 201606
  60. Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress to Ameliorate Leptin Resistance in Obesity, FRONTIERS IN ENDOCRINOLOGY, 7, 20160608
  61. Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation, BRITISH JOURNAL OF PHARMACOLOGY, 173(15), 2434-2445, 201608
  62. Immobilization stress-induced anorexia is mediated independent of MyD88, NEUROREPORT, 27(13), 974-977, 20160907
  63. Possible involvement of endoplasmic reticulum stress in the pathogenesis of Alzheimer's disease., Endoplasmic Reticulum Stress in Diseases, 2, 107-118, 2015
  64. Endoplasmic reticulum stress in the pathogenesis of diabetes., Diabesity, 1, 31-33, 2015
  65. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, NEUROSCIENCE LETTERS, 629, 241-244, 20160826
  66. Unique pharmacological property of ISRIB in inhibition of A beta-induced neuronal cell death, JOURNAL OF PHARMACOLOGICAL SCIENCES, 131(4), 292-295, 201608
  67. Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478(2), 716-720, 20160916
  68. Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78, SCIENTIFIC REPORTS, 6, 20160928
  69. Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance, FRONTIERS IN PHARMACOLOGY, 7, 20160930
  70. Possible integrative Actions of Leptin and insulin Signaling in the Hypothalamus Targeting energy Homeostasis, FRONTIERS IN ENDOCRINOLOGY, 7, 20161020
  71. Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling, MOLECULAR METABOLISM, 6(1), 159-172, 201701
  72. Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in Neuronal Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(8), 1161-1164, 201708
  73. Neuroprotective effects of 4-phenylbutyric acid and its derivatives: Possible therapeutics for neurodegenerative diseases., Journal of Health Science, 5, 9-17, 2017
  74. Implementation and Evaluation of Genetic Testing Seminars about Lifestyle-related Disease Prevention in Pharmacy Insurance -The Need for Cooperation between the Pharmacy and the University in Genetic Testing-, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 137(12), 1517-1531, 201712
  75. Mechanisms of the action of adenine on anti-allergic effects in mast cells, IMMUNITY INFLAMMATION AND DISEASE, 6(1), 97-105, 201803
  76. TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses, BIOTECHNOLOGY LETTERS, 40(6), 915-922, 201806
  77. Leptin resistance in metabolic disorders: possible mechanisms and treatments., Frontiers in Endocrinology, 8(300), 1-2, 20171102
  78. Link between endoplasmic reticulum stress and autophagy in neurodegenerative diseases., Endoplasmic Reticulum Stress in Diseases, 4, 37-45, 20171116
  79. Incorporation of the Endoplasmic Reticulum Stress-Induced Spliced Form of XBP1 mRNA in the Exosomes, FRONTIERS IN PHYSIOLOGY, 9, SEP 26 2018