Toru Hosoi

Last Updated :2017/09/04

Affiliations, Positions
Graduate School of Biomedical & Health Sciences (Medicinal Sciences Major), Associate Professor
E-mail
toruhhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, HOKKAIDO UNIVERSITY
  • Master of Pharmaceutical Science, HOKKAIDO UNIVERSITY

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy

Educational Activity

Course in Charge

  1. 2017, Liberal Arts Education Program1, 1Term, Foundation biology for life science
  2. 2017, Liberal Arts Education Program1, 1Term, Foundation biology for life science
  3. 2017, Undergraduate Education, 1Term, Pharmacotherapy A
  4. 2017, Undergraduate Education, 3Term, Clinical Pharmacology A
  5. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced Lecture on Creation and Development of Biomedical Sciences
  6. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced Lecture on Creation and Development of Biomedical Sciences
  7. 2017, Graduate Education (Master's Program) , First Semester, Seminar on molecular pharmacotherapeutics
  8. 2017, Graduate Education (Master's Program) , Second Semester, Seminar on molecular pharmacotherapeutics
  9. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Pharmacotherapy
  10. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Pharmacotherapy
  11. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced research on Pharmacotherapy
  12. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Pharmacotherapy

Research Activities

Academic Papers

  1. Expression of leptin receptors and induction of IL-1beta transcript in glial cells., Biochem. Biophys. Res. Commun., 273(1), 312-315, 20000601
  2. Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis., Am. J. Physiol., 279(1), R141-R147, 20000701
  3. Subdiaphragmatic vagotomy fails to inhibit intravenous leptin-induced IL-1beta expression in the hypothalamus., Am. J. Physiol., 282(2), R627-R631, 20020201
  4. The mechanisms of immune-to-brain communication in inflammation as a drug target., Curr Drug Targets Inflamm Allergy., 1(3), 257-262, 20020901
  5. Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms., Brain Res., 949(1-2), 139-146, 20020901
  6. The presence and functions of muscarinic receptors in human T cells: the involvement in IL-2 and IL-2 receptor system., Life Sci., 72(18-19), 2121-2126, 20030301
  7. Inhibition of leptin-induced IL-1beta expression by glucocorticoids in the brain., Brain Res., 969(1-2), 95-101, 20030401
  8. A beta-induced TNF-alpha expression and acetylcholine action in mouse glial cells., Life Sci., 72(18-19), 2117-2120, 20030301
  9. Cholecystokinin inhibits food intake independent of interleukin-1 beta expression in the brain., Biol. Pharm. Bull., 26(8), 1181-1183, 20030801
  10. Induction of murine HRD1 in experimental cerebral ischemia., Mol. Brain Res., 130(1-2), 30-38, 20041101
  11. Bacterial endotoxin induces STAT3 activation in the mouse brain., Brain Res., 1023(1), 48-53, 20041001
  12. Functional role of acetylcholine in the immune system., Front Biosci., 9(1), 2414-2419, 20040901
  13. Effect of subdiaphragmatic vagotomy on bacterial DNA-induced IL-1beta expression in the mouse hypothalamus., Brain Res., 1028(2), 233-237, 20041201
  14. Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction., J. Pharmacol. Exp. Ther., 311(1), 388-393, 20041001
  15. Sodium 4-phenylbutyrate protects against cerebral ischemic injury., Mol Pharmacol, 66(4), 899-908, 20041001
  16. Biochemical changes in the brain of senescence-accelerated mouse P8 and P10., International Congress Series, 1260, 91-97, 2004
  17. Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells., Mol. Brain Res., 124(2), 159-164, 20040501
  18. LPS induces stefin A3 expression in mouse primary cultured glial cells, MOLECULAR BRAIN RESEARCH, 140(1-2), 138-141, OCT 31 2005
  19. Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 28(8), 1514-1516, AUG 2005
  20. STAT3 activation and c-FOS expression in the brain following peripheral administration of bacterial DNA., J. Neuroimmunol., 158(1-2), 40-49, 20050101
  21. Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion, AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 120(1-2), 104-107, JUN 15 2005
  22. 2-aminopurine inhibits leptin receptor signal transduction, EUROPEAN JOURNAL OF PHARMACOLOGY, 553(1-3), 61-66, DEC 28 2006
  23. Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress, JOURNAL OF NEUROCHEMISTRY, 97(5), 1259-1268, JUN 2006
  24. PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 340(1), 286-290, FEB 3 2006
  25. Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17(2), 184-186, 20070201
  26. Akt up- and down-regulation in response to endoplasmic reticulum stress, BRAIN RESEARCH, 1152, 27-31, JUN 4 2007
  27. Vanadate inhibits endoplasmic reticulum stress responses, EUROPEAN JOURNAL OF PHARMACOLOGY, 594(1-3), 44-48, OCT 10 2008
  28. Endoplasmic Reticulum Stress Induces Leptin Resistance, MOLECULAR PHARMACOLOGY, 74(6), 1610-1619, DEC 2008
  29. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells, NEUROCHEMISTRY INTERNATIONAL, 54(1), 1-6, JAN 2009
  30. Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance., Journal of Medical Investigation, 56, 296-298, 2009
  31. Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities, CLINICAL SCIENCE, 118(1-2), 19-29, JAN 2010
  32. A unique modulator of endoplasmic reticulum stress-signalling pathways: the novel pharmacological properties of amiloride in glial cells, BRITISH JOURNAL OF PHARMACOLOGY, 159(2), 428-437, JAN 2010
  33. Homocysteine induces X-box-binding protein 1 splicing in the mice brain, NEUROCHEMISTRY INTERNATIONAL, 56(2), 216-220, JAN 2010
  34. Potential Down-Regulation of Salivary Gland AQP5 by LPS via Cross-Coupling of NF-kappa B and p-c-Jun/c-Fos, AMERICAN JOURNAL OF PATHOLOGY, 177(2), 724-734, AUG 2010
  35. Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice, PLOS ONE, 5(9), SEP 2 2010
  36. TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress, JOURNAL OF PHARMACOLOGICAL SCIENCES, 114(2), 230-233, OCT 2010
  37. Novel Therapeutic Approach Based on Recent Understanding of the Development of Metabolic Syndrome, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 131(11), 1557-1562, NOV 2011
  38. Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded proteinresponses in cultured glial cells., PLoS One, 7((6)), e40144, 20120601
  39. Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance., Front Endocrinol (Lausanne), 20120101
  40. Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(1), 84-90, JAN 2012
  41. Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease: Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer's Disease, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118(3), 319-324, MAR 2012
  42. Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice, GENE, 497(2), 340-343, APR 15 2012
  43. Inhibition of Casein Kinase 2 Modulates XBP1-GRP78 Arm of Unfolded Protein Responses in Cultured Glial Cells, PLOS ONE, 7(6), JUN 29 2012
  44. ER stress-mediated regulation of immune function under glucose-deprived condition in glial cells: Up- and down-regulation of PGE(2) + IFN gamma-induced IL-6 and iNOS expressions, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441(2), 525-528, NOV 15 2013
  45. Tributyltin-induced endoplasmic reticulum stress and its Ca2+-mediated mechanism, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(1), 137-146, OCT 1 2013
  46. ER stress upregulated PGE(2)/IFN gamma-induced IL-6 expression and down-regulated iNOS expression in glial cells, SCIENTIFIC REPORTS, 3, DEC 2 2013
  47. Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress, EMBO MOLECULAR MEDICINE, 6(3), 335-346, MAR 2014
  48. TERT attenuated ER stress-induced cell death, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 447(2), 378-382, MAY 2 2014
  49. Inhibition of inducible nitric oxide synthase and interleukin-1 beta expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide, BRAIN RESEARCH, 1558, 11-17, APR 16 2014
  50. Caffeine attenuated ER stress-induced leptin resistance in neurons, NEUROSCIENCE LETTERS, 569, 23-26, MAY 21 2014
  51. Therapeutic potential of flurbiprofen against obesity in mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 449(1), 132-134, JUN 20 2014
  52. Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells, SCIENTIFIC REPORTS, 4, NOV 18 2014
  53. Stress-Induced Neuroprotective Effects of Epiregulin and Amphiregulin, PLOS ONE, 10(2), FEB 12 2015
  54. Possible involvement of 15-deoxy-Delta(12,14)-prostaglandin J(2) in the development of leptin resistance, JOURNAL OF NEUROCHEMISTRY, 133(3), 343-351, MAY 2015
  55. Stress-induced neuroprotective effects of epiregulin and amphiregulin., PLOS One, 10, e0118280, 2015 Feb
  56. Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460, 628-632, 2015 May
  57. Implementation and Evaluation of Genetic Testing Seminars on Lifestyle-related Disease Prevention for Pharmacy Students, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136(2), 337-350, FEB 2016
  58. The Mechanisms and Pharmacological Strategy for Treatment of ER Stress-induced Metabolic Syndrome, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136(6), 827-830, JUN 2016
  59. Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress to Ameliorate Leptin Resistance in Obesity, FRONTIERS IN ENDOCRINOLOGY, 7, JUN 8 2016
  60. Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation, BRITISH JOURNAL OF PHARMACOLOGY, 173(15), 2434-2445, AUG 2016
  61. Immobilization stress-induced anorexia is mediated independent of MyD88, NEUROREPORT, 27(13), 974-977, SEP 7 2016
  62. Possible involvement of endoplasmic reticulum stress in the pathogenesis of Alzheimer's disease., Endoplasmic Reticulum Stress in Diseases, 2, 107-118
  63. Endoplasmic reticulum stress in the pathogenesis of diabetes., Diabesity, 1, 31-33
  64. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, NEUROSCIENCE LETTERS, 629, 241-244, AUG 26 2016
  65. Unique pharmacological property of ISRIB in inhibition of A beta-induced neuronal cell death, JOURNAL OF PHARMACOLOGICAL SCIENCES, 131(4), 292-295, AUG 2016
  66. Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478(2), 716-720, SEP 16 2016
  67. Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78, SCIENTIFIC REPORTS, 6, SEP 28 2016
  68. Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance, FRONTIERS IN PHARMACOLOGY, 7, SEP 30 2016
  69. Possible integrative Actions of Leptin and insulin Signaling in the Hypothalamus Targeting energy Homeostasis, FRONTIERS IN ENDOCRINOLOGY, 7, OCT 20 2016
  70. Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling, MOLECULAR METABOLISM, 6(1), 159-172, JAN 2017
  71. Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in Neuronal Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(8), 1161-1164, AUG 2017