TAKEHIKO DOI

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Assistant Professor
E-mail
take-doi02hiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Kyushu University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Pediatrics

Research Keywords

  • Hematology, Immunology, Rheumatology

Affiliated Academic Societies

  • Japan Pediatric Society
  • Japanese Society of Hematology
  • The Japanese Society of Pediatric Hematology/Oncology
  • Japan College of Rheumatology
  • Pediatric Rheumatology Association of Japan
  • Japanese Society For Pediatric Infection Diseases
  • Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition
  • Japanese Society of Emergency Pediatrics

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Systemic Disease Control
  2. 2024, Undergraduate Education, Intensive, Introduction to clinical clerkship
  3. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2024, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2024, Graduate Education (Master's Program) , First Semester, Seminar
  6. 2024, Graduate Education (Master's Program) , Second Semester, Seminar
  7. 2024, Graduate Education (Master's Program) , First Semester, Research
  8. 2024, Graduate Education (Master's Program) , Second Semester, Research
  9. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pediatrics
  10. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pediatrics
  11. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pediatrics
  12. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pediatrics
  13. 2024, Graduate Education (Master's Program) , First Semester, Genetic services informatics, Practice
  14. 2024, Graduate Education (Master's Program) , First Semester, Research on Genetic Counseling
  15. 2024, Graduate Education (Master's Program) , Second Semester, Research on Genetic Counseling

Research Activities

Academic Papers

  1. Dexamethasone palmitate as an etoposide-free treatment for children with hemophagocytic lymphohistiocytosis after hematopoietic cell transplantation, Bone Marrow Transplantation, 20230829
  2. Germline and somatic RUNX1 variants in a pediatric bone marrow failure cohort, American Journal of Hematology, 98(5), E102-E105, 20230220
  3. A retrospective survey of patients who discontinued participation in the JPLSG HLH-2004 clinical trial, International Journal of Hematology, 2022
  4. Reduced incidence of hemophagocytic lymphohistiocytosis in Japan during the COVID-19 pandemic, International Journal of Hematology, 2022
  5. ★, Lethal Interstitial Lung Disease Associated with a Gain-of-Function Mutation in IFIH1, Journal of Clinical Immunology, 20230501
  6. BRAF V600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis, Haematologica, 107(7), 1719-1725, 20220701
  7. Reduced incidence of hemophagocytic lymphohistiocytosis in Japan during the COVID-19 pandemic, International Journal of Hematology, 115(3), 446-448, 20220203
  8. A retrospective survey of patients who discontinued participation in the JPLSG HLH-2004 clinical trial, INTERNATIONAL JOURNAL OF HEMATOLOGY, 116(3), 434-441, 202209
    Link to Paper Search Results by DOI
  9. ★, H2-M3-restricted CD8+ T cells induced by peptide-pulsed dendritic cells confer protection against Mycobacterium tuberculosis., Journal of immunology (Baltimore, Md. : 1950), 178(6), 2007
  10. Long-term liposteroid therapy for idiopathic pulmonary hemosiderosis., European journal of pediatrics, 172(11), 2013
  11. Erratum to: Long-term liposteroid therapy for idiopathic pulmonary hemosiderosis., European journal of pediatrics, 174(12), 2015
  12. Blue rubber bleb nevus syndrome with knee joint disorder, PEDIATRICS INTERNATIONAL, 58(8), 740-743, 201608
    Link to Paper Search Results by DOI
  13. Nationwide Survey of Patients with Primary Immunodeficiency Diseases in Japan, JOURNAL OF CLINICAL IMMUNOLOGY, 31(6), 968-976, 2011
  14. Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice., Journal of immunology (Baltimore, Md. : 1950), 176(4), 20060204
  15. Nephrolithiasis as an extra-intestinal presentation of pediatric inflammatory bowel disease unclassified., Journal of Crohn's & colitis, 4(6), 2010
  16. Potent induction of IFN-gamma production from cord blood NK cells by the stimulation with single-stranded RNA., Journal of clinical immunology, 31(4), 2011
  17. Treatment choice of immunotherapy or further chemotherapy for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis., Pediatric blood & cancer, 59(2), 2012
  18. A non-invasive diagnosis of histiocytic necrotizing lymphadenitis by means of gene expression profile analysis of peripheral blood mononuclear cells., Journal of clinical immunology, 33(5), 2013
  19. Neonatal hemophagocytic lymphohistiocytosis associated with a vertical transmission of coxsackievirus B1., Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 19(6), 2013
  20. Development of Kawasaki disease in a patient with PFAPA., Pediatrics international : official journal of the Japan Pediatric Society, 55(6), 2013
  21. Staphylococcal endocarditis as the first manifestation of heritable protein S deficiency in childhood., Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 20(2), 2014
  22. ★, Limited renal prophylaxis in regular plasmatherapy for heritable ADAMTS13 deficiency, Pediatr Blood Cancer, 60, 1557-1558, 2013
  23. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice, Proc Natl Acad Sci U S A, 107, 13022-13027, 2010
  24. Paediatric presentation and outcome of congenital protein C deficiency in Japan., Haemophilia, 19, 378-384, 2013
  25. Neonatal asphyxia and renal failure as the presentation of non-inherited protein C deficiency., J Perinatol, 33, 239-241, 2013
  26. Acute liver failure as the initial manifestation of Wilson disease triggered by human parvovirus b19 infection, Pediatr Infect Dis J, 31, 103-104, 2012
  27. Complete immunotolerance induction after FEIBA prophylaxis in a haemophilia A patient with high-titre inhibitor., Haemophilia, 18, 75-77, 2012
  28. Recurrent atrial fibrillation after high-dose methylprednisolone therapy in a girl with lupus-associated hemophagocytic syndrome, Lupus, 20, 871-875, 2011
  29. CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL., Leukemia, 22, 1207-1213, 2008
  30. Infantile hypophosphatasia combined with vitamin B6-responsive seizures and reticular formation lesions on magnetic resonance imaging: A case report, BRAIN & DEVELOPMENT, 40(2), 140-144, 201802
    Link to Paper Search Results by DOI
  31. Repeated Paradoxical Reactions in a Patient with Meningeal and Intracranial Tuberculosis during Antituberculous Treatment with Corticosteroids, 122(7), 1213-1219, 201807
  32. Early administration of adalimumab for paediatric uveitis due to Behcet's disease, PEDIATRIC RHEUMATOLOGY, 17, 20190610
    Link to Paper Search Results by DOI
  33. Scurvy Presenting with Fever, Anemia, and Gait Disabilities in a Boy with Autism Spectrum Disorder, 123(8), 1283-1289, 201908
  34. Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusion-dependent pyruvate kinase deficiency anemia, HEMATOLOGY REPORTS, 12(1), 2020
    Link to Paper Search Results by DOI
  35. Inherited CARD9 Deficiency in a Child with Invasive Disease Due to Exophiala dermatitidis and Two Older but Asymptomatic Siblings, JOURNAL OF CLINICAL IMMUNOLOGY, 41(5), 975-986, 20210210
    Link to Paper Search Results by DOI
  36. Atypical X-linked Severe Combined Immunodeficiency with a Phenotype of T+/lowB+NK+, 124(6), 1009-1014, 20200601
  37. Lymphoproliferative disorders and inborn errors of immunity, 61(9), 1365-1372, 20200908
  38. Salvage therapy with 2-chlorodeoxyadenosine for refractory and relapsed pediatric Langerhans cell histiocytosis: an updated nationwide survey in Japan, International Journal of Hematology, 113(3), 461-463, 20210209
    Link to Paper Search Results by DOI
  39. Clinical Courses of IKAROS and CTLA4 Deficiencies: A Systematic Literature Review and Retrospective Longitudinal Study, FRONTIERS IN IMMUNOLOGY, 12, 20220111
    Link to Paper Search Results by DOI

Publications such as books

  1. 2023/03/01, The Journal of Pediatric Practice, Scholarly Book, Joint work, 日本語, 03869806

Invited Lecture, Oral Presentation, Poster Presentation

  1. Non-myeloablative transplantation for a case of juvenile-onset lymphomatoid granulomatosis, Takehiko Doi, Maiko Shimomura, Yusuke Imanaka, Yoko Mizoguchi, Shuhei Karakawa, Ryouta Komori, Satoshi Okada, Hiroshi Kawaguchi, Masao Kobayashi, The 39th Annual Meeting of the Japan Society for Hematopoietic Cell Transplantation, 2017/03/02, Without Invitation, Japanese, The Japanese Society for Hematopoietic Cell TRansplantation, Shimane