Michihiro Hide

Last Updated :2020/09/15

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
Web Site
I am a dermatologist and dealing with a wide range of dermatology, especially in a field of skin allergy.

Basic Information

Academic Degrees

  • Ph.D. (Medicine), Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Dermatology

Research Keywords

  • IgE|食物多糖類
  • imaging|hereditary
  • Mediator|atopic dermatitis
  • treatment|surface plasmon resonance
  • アトピー|Type I allergy
  • gene|urticaria
  • sweat|汗
  • local surface plasmon resonance|angioedema
  • Mast cell
  • pathophysiology

Educational Activity

Course in Charge

  1. 2020, Undergraduate Education, Year, Clinical diagnosis and treatment II
  2. 2020, Undergraduate Education, Intensive, Practice for medical research
  3. 2020, Undergraduate Education, First Semester, Dermatology
  4. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Dermatology
  5. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Dermatology
  6. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced research on Dermatology
  7. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Dermatology
  8. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Dermatology
  9. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Dermatology
  10. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Dermatology
  11. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Dermatology

Research Activities

Academic Papers

  1. Micro cell isolation column for allergic diagnosis, JAPANESE JOURNAL OF APPLIED PHYSICS, 55(3), 201603
  2. A case of erythritol allergy studied by basophil histamine release and CD203c expression in vitro in addition to a challenge test in vivo., J Invest Allergol Clin Immunol., 26(2), 135-136, 2016
  3. Pulverized konjac glucomannan ameliorates oxazolone-induced colitis in mice, EUROPEAN JOURNAL OF NUTRITION, 54(6), 959-969, 201509
  4. Evaluation of recombinant MGL_1304 produced by Pichia pastoris for clinical application to sweat allergy, ALLERGOLOGY INTERNATIONAL, 64(3), 266-271, 201507
  5. A Case of Erythrokeratodermia Variabilis Successfully Treated with Oral Vitamin A, J Dermatol, 42, 1-2, 2015
  6. Increased thrombin generation potential in patients with chronic spontaneous urticaria, Allergol Int, 64(1), 96-98, 2015
  7. A human monoclonal IgE antibody that binds to MGL_1304, a major allergen in human sweat, without activation of mast cells and basophils, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 468(1-2), 99-104, 20151204
  8. Identification of a cell line producing high levels of TSLP: Advantages for screening of anti-allergic drugs, JOURNAL OF IMMUNOLOGICAL METHODS, 402(1-2), 9-14, 20140115
  9. Remission rate of patients with wheat allergy sensitized to hydrolyzed wheat protein in facial soap., Allergol lnt., 65(1), 109-111, 2016
  10. The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling, NEUROCHEMISTRY INTERNATIONAL, 93, 82-94, 201602
  11. Diagnosis of immediate-type allergy using surface plasmon resonance, OPTICAL MATERIALS EXPRESS, 6(4), 1339-1348, 20160401
  12. Definition, aims, and implementation of GA(2)LEN Urticaria Centers of Reference and Excellence, ALLERGY, 71(8), 1210-1218, 201608
  13. Balloon Cell Malignant Melanoma in a Young Female: A Case Report and Review of the Literature, CASE REPORTS IN ONCOLOGY, 9(1), 262-266, 2016
  14. Clinical diagnosis of type I allergy by means of SPR imaging with less than a microliter of peripheral blood, Sensing and BioSensing Research, 2, 43-48, 2014
  15. Environmental factors associated with childhood eczema: Findings from a national web-based survey, ALLERGOLOGY INTERNATIONAL, 65(4), 420-424, 201610
  16. Oral administration of -carotene or lycopene prevents atopic dermatitis-like dermatitis in HR-1 mice, JOURNAL OF DERMATOLOGY, 43(10), 1188-1192, 201610
  17. EEAGI/GA(2)LEN/EDF/WAO Guidelines pertaining to the definition, classification, diagnosis and management of urticaria: 2013 revision and update, Alergologia Polska-Polish Journal of Allergology, 2(1), T1-T23, 2015
  18. Systematised naevus sebaceus resulting from post-zygotic mutation in HRAS, AUSTRALASIAN JOURNAL OF DERMATOLOGY, 58(1), 58-60, 201702
  19. One-year safety and efficacy study of bilastine treatment in Japanese patients with chronic spontaneous urticaria or pruritus associated with skin diseases, JOURNAL OF DERMATOLOGY, 44(4), 375-385, 201704
  20. Efficacy and safety of bilastine in Japanese patients with chronic spontaneous urticaria: A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II/III study, ALLERGOLOGY INTERNATIONAL, 66(2), 317-325, 201704
  21. Evaluation of skin perfusion pressure to assess refractory foot ulcers, JOURNAL OF WOUND CARE, 26(5), 267-270, 201705
  22. Contact urticaria syndrome with IgE antibody against a cefotiam-unique structure, evoked by nonapparent exposure to cefotiam, CLINICAL AND EXPERIMENTAL DERMATOLOGY, 42(5), 527-531, 201707
  23. Airborne virus detection by a sensing system using a disposable integrated impaction device, JOURNAL OF BREATH RESEARCH, 10(3), 201609
  24. Analysis of primary treatment and prognosis of spontaneous urticaria, ALLERGOLOGY INTERNATIONAL, 66(3), 458-462, 201707
  25. Sweat allergy: Extrinsic or intrinsic?, JOURNAL OF DERMATOLOGICAL SCIENCE, 87(1), 3-9, 201707
  26. Efficacy and safety of omalizumab in Japanese and Korean patients with refractory chronic spontaneous urticaria, JOURNAL OF DERMATOLOGICAL SCIENCE, 87(1), 70-78, 201707
  27. The first nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan, JOURNAL OF INFECTION AND CHEMOTHERAPY, 23(8), 503-511, 201708
  28. Novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair, J Dermatol, 43(11), 1384-1385, 2016
  29. Predictive phenotyping of inherited ichthyosis by next generation DNA sequencing, Br J Dermatol, 176(1), 249-251, 201701
  30. Angioedema associated with excessive sweating and sweat allergy, J Dermatol, e58-e59, 201704
  31. Contact urticaria syndrome with IgE antibody against cefotiam-unique structure evoked by non-apparent exposure to cefotiam: A case report, Clin Exp Dermatol, 2016
  32. Injury due to extravasation of thiopental and propofol: risks/effects o f local cooling/warming in rats, Biochemistry and Biophysics Reports, 8, 207-211, 201609
  33. Case of cholinergic urticaria accompanied by anaphylaxis, JOURNAL OF DERMATOLOGY, 44(11), 1291-1294, 201711
  34. Impedance-Based Living Cell Analysis for Clinical Diagnosis of Type I Allergy, SENSORS, 17(11), 201711
  35. Staphylococcus aureus from atopic dermatitis skin alters cytokine production triggered by monocyte-derived Langerhans cell, JOURNAL OF DERMATOLOGICAL SCIENCE, 88(3), 271-279, 201712
  36. Different hypersensitivities against homologous proteins of MGL_1304 in patients with atopic dermatitis, ALLERGOLOGY INTERNATIONAL, 67(1), 103-108, 201801
  37. The international WAO/EAACI guideline for the management of hereditary angioedema - the 2017 revision and update, WORLD ALLERGY ORGANIZATION JOURNAL, 11, 20180227
  38. Evaluation of Risk of Injury by Extravasation of Hyperosmolar and Vasopressor Agents in a Rat Model, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 41(6), 951-956, 201806
  39. The international WAO/EAACI guideline for the management of hereditary angioedemaThe 2017 revision and update, ALLERGY, 73(8), 1575-1596, 201808
  40. Impact of chronic urticaria on quality of life and work in Japan: Results of a real-world study, JOURNAL OF DERMATOLOGY, 45(8), 963-970, 201808
  41. Chronic spontaneous urticaria and the extrinsic coagulation system, Allergology International, 67(2), 191-194, 201804
  42. Prognosis of adult-onset clinically amyopathic dermatomyositis treated with only topical therapy, J Dermatol, 44(7), e178-e179, 201707
  43. A case of Kaposi's varicelliform eruption progressing to herpes simplex virus hepatitis in an immunocompetent patient, Clin Exp Dermatol, 43(5), 636-638, 201807
  44. Pre-symptomatic genetic diagnosis of two siblings with hereditary angioedema, presenting with unusual normal levels of serum C4, J Dermatol, 45(2), e31-e32, 201802
  45. A unique clinical phenotype of a patient bearing a newly identified deletion mutation in the PSENEN gene along with the pathogenic serum desmoglein-1 antibody, Clin Exp Dermatol, 43(3), 329-332, 201804
  46. Histamine and TLR ligands synergistically induce endothelial-cell gap-formation by the extrinsic coagulating pathway., J Allergy Clin Immunol, 141(3), 1115-1118, 201803
  47. Outbreak of immediate-type hydrolyzed wheat protein allergy due to a facial soap in Japan., Journal of Allergy and Clinical Immunology., 140(3), 879-881, 201709
  48. Activation of Human Peripheral Basophils in Response to High IgE Antibody Concentrations without Antigens, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(1), 20190101
  49. Staphylococcus aureus from atopic dermatitis skin accumulates in the lysosomes of keratinocytes with induction of IL-1 alpha secretion via TLR9, ALLERGY, 74(3), 560-571, 201903
  50. Efficacy and safety of rupatadine in Japanese adult and adolescent patients with chronic spontaneous urticaria: A double-blind, randomized, multicenter, placebo-controlled clinical trial, ALLERGOLOGY INTERNATIONAL, 68(1), 59-67, 201901
  51. Development of SPR Imaging-Impedance Sensor for Multi-Parametric Living Cell Analysis, SENSORS, 19(9), 20190501
  52. Staphylococcus aureus in atopic dermatitis: Strain-specific cell wall proteins and skin immunity, ALLERGOLOGY INTERNATIONAL, 68(3), 309-315, 201907
  53. Case of anaphylaxis to lansoprazole confirmed by histamine release test and oral provocation test, J Dermatol, 46(4), e124-e125, Epub2018 Aug 27
  54. Long-term safety and efficacy of rupatadine in Japanese patients with itching due to chronic spontaneous urticaria, dermatitis, or pruritus: a 12-month, multicenter, open-label clinical trial, J Dermatol Sci, 94(3), 339-345
  55. Decreased intracellular histamine concentration and basophil activation in anaphylaxis, ALLERGOLOGY INTERNATIONAL, 69(1), 78-83, 202001
  56. Dupilumab shows long-term safety and efficacy in patients with moderate to severe atopic dermatitis enrolled in a phase 3 open-label extension study, JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 82(2), 377-388, 202002
  57. A single reaction-diffusion equation for the multifarious eruptions of urticaria, PLOS COMPUTATIONAL BIOLOGY, 16(1), 202001
  58. Efficacy of switching to bilastine, a histamine H1 receptor antagonist, in patients with chronic spontaneous urticaria (H1-SWITCH): study protocol for a randomized controlled trial, TRIALS, 21(1), 20200106
  59. Type-I-hypersensitivity to 15 kDa, 28 kDa and 54 kDa proteins in vitellogenin specific to Gadus chalcogrammus roe, ALLERGOLOGY INTERNATIONAL, 69(2), 253-260, 202004
  60. Clinical utility of the basophil activation test in the diagnosis of sweat allergy, ALLERGOLOGY INTERNATIONAL, 69(2), 261-267, 202004
  61. Efficacy, pharmacokinetics, and safety of icatibant for the treatment of Japanese patients with an acute attack of hereditary angioedema: A phase 3 open-label study, ALLERGOLOGY INTERNATIONAL, 69(2), 268-273, 202004
  62. EAACI/GA(2)LEN/EDF/WAO guidelines for the definition, classification, diagnosis and treatment of urticaria, ALERGOLOGIA POLSKA-POLISH JOURNAL OF ALLERGOLOGY, 7(1), 1-28, 2020
  63. Roles of omalizumab in various allergic diseases, ALLERGOLOGY INTERNATIONAL, 69(2), 167-177, 202004
  64. Management of urticarial vasculitis: A worldwide physician perspective, WORLD ALLERGY ORGANIZATION JOURNAL, 13(3), 202003
  65. Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients, CLINICAL AND TRANSLATIONAL ALLERGY, 10(1), 20200601
  66. Randomized double-blind cross-over trial of bath additive containing tannic acid in patients with atopic dermatitis, JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY, 3(3), 56-61, 202006
  67. Efficacy and safety of dupilumab in Japanese adults with moderate-to-severe atopic dermatitis: a subanalysis of three clinical trials, BRITISH JOURNAL OF DERMATOLOGY, 183(1), 39-51, 202007
  68. Dupilumab Provides Favorable Safety and Sustained Efficacy for up to 3 Years in an Open-Label Study of Adults with Moderate-to-Severe Atopic Dermatitis, AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 21(4), 567-577, 202008
  69. Rechallenge of programmed cell death 1 inhibitor after an interval with dacarbazine treatment may be effective for advanced malignant melanoma, JOURNAL OF DERMATOLOGY, 47(8), 907-910, 202008

Publications such as books

  1. 2015/04, Label-Free Biosensor Methods in Drug Discovery, Surface Plasomon Resonance for Clinical Diagnosis of Type I Allergy, Humana Press, 2015, 4, Yuhki Yanase, Michihiro Hide, 373-385

Invited Lecture, Oral Presentation, Poster Presentation

  1. Chronic Urticaria and Atopic Dermatitis in the Elderly, Michihiro Hide, WAO International Scientific Conference (WISC), 2014/12/09, With Invitation, Rio de Janeiro, Brazil
  2. Management of urticaria based on the international guideline and its adaptations: Tips from Japanese guideline for urticaria, Michihiro Hide, 3rd Eastern Asia Dermatology Congress (EADC), 2014/09/25, With Invitation, Jeju, Korea
  3. Application of SPR imaging for detection of individual living cell reaction and clinical diagnosis, Michihiro Hide, 2014 4th Research Week-International Symposium of Oral Medicine, 2014/05/24, With Invitation, Taipei
  4. Surface plasmon resonance for cell-based diagnosis, Michihiro Hide, 5th Hiroshima Conferenence on Education and Science in Dentistry, 2013/10/12, With Invitation, Hiroshima, Japan
  5. Urticaria in Asia., Michihiro Hide, European Academy of Allergy and Clinical Immunology & World Allergy Organization World Allergy &Asthma Congress, 2013/06/25, With Invitation, Milan, Italy
  6. Application of SPR imaging for detection of individual living cell reaction and clinical diagnosis, Michihiro Hide, International Workshop on Nanodevice and Bio Systems Technologies 2013, 2013/03/03, With Invitation, Higashi-Hiroshima, Japan
  7. Postgraduate Course 22: URTICARIA & ANGIOEDEMA TRACK -Diagnosis and Treatment of Hereditary Angioedema (HAE) Acute and Prophylactic Management", Michihiro Hide, WISC 2012; WAO International Scientific Conference, 2012/12/08, With Invitation, Hyderabad
  8. Approach to Refractory Urticaria and Angioedema, Michihiro Hide, WISC 2012; WAO International Scientific Conference, 2012/12/07, With Invitation, Hyderabad
  9. Pathogenesis of chronic urticaria: From definition, etiology and treatments, Michihiro Hide, 2nd East Asian Dermatology Congress, 2012/06/14, With Invitation, Beijin
  10. Prophylactic Intervention with Antihistamines on the Clinical Course of Idiopathic Urticaria, Michihiro Hide, Luncheon Seminar 2 The 36th Annual Meeting of the Japanese Society for Investigative Dermatology, 2011/12/10, With Invitation, Kyoto
  11. Increase of coagulation and its potential in plasma of chronic spontaneous urticaria, Michihiro Hide, Workshop 19 Beyond CRP: Biomarkers in Cutaneous Disease, 24nd World Congress of Dermatology, 2011/05/26, With Invitation, Seoul
  12. Cholinergic urticaria and sweat allergy, Michihiro Hide, Symptosium 12 Urticarial Syndromes - Angioedema, 22nd World Congress of Dermatology, 2011/05/25, With Invitation, Seoul
  13. Biomarkers in chronic urticaria, Michihiro Hide, Ancillary Meeting at 22nd World Congress of Dermatology Contact Dermatitis and Skin Allergy, 2011/05/24, With Invitation, Seoul
  14. Application of SPR imaging for detection of individual living cell reaction and clinical diagnosis, Michihiro Hide, Hiroshima University Nano-device Workshop, "Electro-optic sensing for intact cell activation and its clinical application", 2015/03/03, With Invitation, Hiroshima University, Higashihiroshima
  15. Introduction: Historical background and global activities of urticaria and angioedema, Michihiro Hide, 23rd World Congress of Dermatology, "Symposium 4 - Urticaria and Angioedema", 2015/06/09, With Invitation, Vancouver
  16. Antihistamines in the treatment of urticaria and angioedema, Michihiro Hide, 23rd World Congress of Dermatology, "Symposium 4 - Urticaria and Angioedema", 2015/06/09, With Invitation, Vancouver
  17. Controversies in CSU and Angioedema, Michihiro Hide, 1st Asian Chronic Spontaneous Urticaria Forum, "National Skin Centre Update in Dermatology and Venereology 2015", 2015/09/04, With Invitation, Singapore
  18. Update in the Pathogenesis of Chronic Urticaria in Adults, Michihiro Hide, The 24nd Word Allergy Congress, " Workshop 3: Recent Update in Chronic Urticaria", 2015/10/14, With Invitation, Seoul, Korea
  19. The role of mast cells in urticaria, Michihiro Hide, 1st GA(2)LEN UCARE Conference and Preceptionship/Session IV: The role of mast cells and basophils in urticaria, 2017/12/01, With Invitation, Barcelona ESADE FORUM
  20. Neuromedin U directly activates human and mouse skin mast cells, Yoshimi Matsuo, Yoshimi Matsuo, Yuhki Yanase, Satoshi Tanaka, Kazuyuki Furuta, Michihiro Hide, 47thThe European Society for Dermatological Research, 2017/09, Without Invitation, Salzburg, Austria
  21. Staphylococcus aureus isolated from patients with atopic dermatitis accumulate in lysosome and induces IL-1alpha via TLR9 in keratinocytes, Masaya Moriwaki, Masaya Moriwaki, Kazumasa Iwamoto, Yoshie Niitsu, Ayako Matsushima, Junzo Hisatsune, Motoyuki Sugai, Michihiro Hide, 47th Annual European Society for Dermatological Research (ESDR) Meeting 2017, 2017/09/27, Without Invitation, Salzburg, Austria
  22. Wheals but no urticaria-Angioedema but no wheals? How not to miss autoinflammatory diseases and Bradykinin-mediated angioedema – and how to treat them?, Michihiro Hide, 24th World Congress of Dermatology, 2019/06/12, With Invitation, Uriach, Milan