Masao Kobayashi

Last Updated :2017/09/01

Affiliations, Positions
Graduate School of Biomedical & Health Sciences (Biomedical Sciences Major), Professor
E-mail
masakhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Pediatrics

Research Keywords

  • Function
  • Hematopoietic progenitor cell
  • neutropenia
  • nursing
  • Malignency
  • Phagocytes
  • hematopoietic stem cell transplantation

Educational Activity

Course in Charge

  1. 2017, Undergraduate Education, Intensive, Systemic Disease Control
  2. 2017, Undergraduate Education, Intensive
  3. 2017, Undergraduate Education, Intensive, Practice for medical research
  4. 2017, Undergraduate Education, Intensive, Clinical Clerkship (Advanced Course)
  5. 2017, Undergraduate Education, First Semester, Pediatrics
  6. 2017, Undergraduate Education, First Semester, Pediatrics
  7. 2017, Graduate Education (Master's Program) , First Semester, Special Course of Biomedical Technology and Informatics
  8. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced research on Pediatrics
  9. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Pediatrics
  10. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Pediatrics
  11. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Pediatrics
  12. 2017, Graduate Education (Doctoral Program) , First Semester, Child health

Research Activities

Academic Papers

  1. Identification of the integrin beta 3 L718P mutation in a pedigree with autosomal dominant thrombocytopenia with anisocytosis, BRITISH JOURNAL OF HAEMATOLOGY, 160(4), 521-529, FEB 2013
  2. Central nervous system complications and neuroradiological findings in children with chronic active EpsteinBarr virus infection, PEDIATRICS INTERNATIONAL, 55(1), 72-78, FEB 2013
  3. Effects of idursulfase enzyme replacement therapy for Mucopolysaccharidosis type II when started in early infancy: Comparison in two siblings, MOLECULAR GENETICS AND METABOLISM, 108(3), 172-177, MAR 2013
  4. Acute severe encephalopathy related to human herpesvirus-6 infection in a patient with carnitine palmitoyltransferase 2 deficiency carrying thermolabile variants, BRAIN & DEVELOPMENT, 35(5), 449-453, MAY 2013
  5. Paroxysmal Periodic Dystonic Postures in an Infant with 18q23 Deletion Syndrome, NEUROPEDIATRICS, 44(3), 163-166, JUN 2013
  6. Heterozygosity for the Y701C STAT1 mutation in a multiplex kindred with multifocal osteomyelitis, HAEMATOLOGICA, 98(10), 1641-1649, OCT 2013
  7. Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia-derived pluipotent stem cells with heterozygous ELANE mutation, Proc Natl Acad Sci USA, 110, 3023-8, 20130601
  8. Abnormal responses of myeloid progenitor cells to recombinant human colony-stimulating factors in congenital neutropenia., Blood, 75, 2143-2149, 19900401
  9. Detection Of Mucor velutinosus in a Blood Culture After Autologous Periperal Blood Stem Cell Transplantation: A Pediatric Case Report, Medical Mycology Journal, 55(2), E43-8, 20140601
  10. ZK7, a novel zinc finger gene is induced by vascular endothelial growth factor and inhibits apoptotic death in hematopoietic cells, CANCER RESEARCH, 60(2), 425-430, JAN 15 2000
  11. Insulin and insulin-like growth factor I support the proliferation of erythroid progenitor cells in bone marrow through the sharing of receptors, BRITISH JOURNAL OF HAEMATOLOGY, 109(3), 555-562, JUN 2000
  12. Abnormalities of primitive myeloid progenitor cells expressing granulocyte colony-stimulating factor receptor in patients with severe congenital neutropenia, BLOOD, 96(13), 4366-4369, DEC 15 2000
  13. A possible role for maternal HLA antibody in a case of alloimmune neonatal neutropenia, TRANSFUSION, 41(5), 615-620, MAY 2001
  14. Significance of the detection of antineutrophil antibodies in children with chronic neutropenia, BLOOD, 99(9), 3468-3471, MAY 1 2002
  15. Human neutrophil antigen-2a expression on neutrophils from healthy adults in western Japan, TRANSFUSION, 42(5), 651-657, MAY 2002
  16. Dysregulation of transcriptions in primary granule constituents, during myeloid proliferation and differentiation in patients with severe congenital neutropenia, JOURNAL OF LEUKOCYTE BIOLOGY, 73(2), 225-234, FEB 2003
  17. Efficacy of prophylactic use of trimethoprim-sulfamethoxazole in autoimmune neutropenia in infancy, JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 25(7), 553-557, JUL 2003
  18. Establishment of a practical enzymatic assay method for determination of isovaleryl-CoA dehydrogenase activity using high-performance liquid chromatography, CLINICA CHIMICA ACTA, 353(1-2), 193-199, MAR 2005
  19. Significance of human neutrophil antigen-2a (NB1) expression and neutrophil number in pregnancy, TRANSFUSION, 44(4), 581-585, APR 2004
  20. A case of adolescent primary adrenal natural killer cell lymphoma, INTERNATIONAL JOURNAL OF HEMATOLOGY, 81(4), 330-334, MAY 2005
  21. Enzymatic diagnosis of medium-chain acyl-CoA dehydrogenase deficiency by detecting 2-octenoyl-CoA production using high-performance liquid chromatography: A practical confirmatory test for tandem mass spectrometry newborn screening in Japan, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 823(2), 122-130, SEP 5 2005
  22. A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 90(8), 1032-1041, AUG 2005
  23. Effect of green tea beverages on efficacy of povidone-iodine, JOURNAL OF HEALTH SCIENCE, 52(3), 324-328, JUN 2006
  24. Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells, GENES CHROMOSOMES & CANCER, 46(1), 67-74, JAN 2007
  25. Autoimmune neutropenia of infancy with multiple brain abscesses during the course of human herpesvirus-6 infection, INTERNATIONAL JOURNAL OF HEMATOLOGY, 84(2), 151-153, AUG 2006
  26. Moyamoya syndrome after cranial irradiation for bone marrow transplantation in a patient with acute leukemia, NEUROPEDIATRICS, 37(6), 364-366, DEC 2006
  27. Frontal cerebral blood flow change associated with infant-directed speech, ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 92(2), F113-F116, MAR 2007
  28. Successful treatment with liposteroid followed by reduced intensity stem cell transplantation in an infant with perforin deficiency presenting with hemophagocytic lymphohistiocytosis, JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 29(3), 178-182, MAR 2007
  29. The function of the frontal lobe in neonates for response to a prosodic voice, EARLY HUMAN DEVELOPMENT, 83(4), 225-230, APR 2007
  30. A novel mutation (Gln433Glu) in exon 12 combined with the G insertion in exon 13 causes severe factor XI deficiency in Japanese patients, BLOOD COAGULATION & FIBRINOLYSIS, 18(5), 519-523, JUL 2007
  31. The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-gamma receptor 1 and has a dominant-negative effect on interferon-gamma signal transduction, JOURNAL OF MEDICAL GENETICS, 44(8), 485-491, AUG 2007
  32. Floating culture promotes the maintenance of hematopoietic stem cells, FEBS LETTERS, 581(24), 4645-4650, OCT 2 2007
  33. The mobility of Bach2 nuclear foci is regulated by SUMO-1 modification, EXPERIMENTAL CELL RESEARCH, 314(4), 903-913, FEB 15 2008
  34. Detection of autoantibodies against NMDA-type glutamate receptor in a patient with recurrent optic neuritis and transient cerebral lesions, NEUROPEDIATRICS, 38(5), 257-260, OCT 2007
  35. Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(30), 10396-10401, JUL 29 2008
  36. Development of a New Enzymatic Diagnosis Method for Very-long-chain Acyl-CoA Dehydrogenase Deficiency by Detecting 2-Hexadecenoyl-CoA Production and its Application in Tandem Mass Spectrometry-based Selective Screening and Newborn Screening in Japan, PEDIATRIC RESEARCH, 64(6), 667-672, DEC 2008
  37. Neurodevelopmental abnormalities associated with severe congenital neutropenia due to the R86X mutation in the HAX1 gene, JOURNAL OF MEDICAL GENETICS, 45(12), 802-807, DEC 2008
  38. SUCCESSFUL TREATMENT OF KASABACH-MERRITT SYNDROME WITH VINCRISTINE AND DIAGNOSIS OF THE HEMANGIOMA USING THREE-DIMENSIONAL IMAGING, PEDIATRIC HEMATOLOGY AND ONCOLOGY, 26(5), 375-380, 2009
  39. Different neuroradiological findings during two stroke-like episodes in a patient with a congenital disorder of glycosylation type Ia, BRAIN & DEVELOPMENT, 31(3), 240-243, MAR 2009
  40. Dizygotic twins with neonatal alloimmune neutropenia associated with maternal anti-human neutrophil antigen-1b antibody, PEDIATRICS INTERNATIONAL, 51(2), 298-299, APR 2009
  41. Epileptic Spasms After Stem Cell Transplantation for Chronic Epstein-Barr Virus Infection, PEDIATRIC NEUROLOGY, 40(5), 404-407, MAY 2009
  42. Ela2 Mutations and Clinical Manifestations in Familial Congenital Neutropenia, JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 31(5), 319-324, MAY 2009
  43. Deficiency of regulatory T cells in children with autoimmune neutropenia, BRITISH JOURNAL OF HAEMATOLOGY, 145(5), 642-647, JUN 2009
  44. Current Situation of Drug Information in the Kindergarten and Nursery Teacher: A Pilot Study, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 129(5), 617-622, MAY 2009
  45. Spinal Epidural Granulocytic Sarcoma in a Child Precedent to Clinical Manifestation of Acute Myeloid Lymphoma -Case Report-, NEUROLOGIA MEDICO-CHIRURGICA, 49(5), 221-224, MAY 2009
  46. Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells, EXPERIMENTAL HEMATOLOGY, 37(7), 857-866, JUL 2009
  47. Short-Term Culture of Umbilical Cord Blood-Derived CD34 Cells Enhances Engraftment Into NOD/SCID Mice Through Increased CXCR4 Expression, STEM CELLS AND DEVELOPMENT, 18(8), 1221-1226, OCT 2009
  48. Successful bone marrow transplantation in chronic granulomatous disease, PEDIATRICS INTERNATIONAL, 51(6), 838-841, DEC 2009
  49. Significance of immature platelet fraction and CD41-positive cells at birth in early onset neonatal thrombocytopenia, INTERNATIONAL JOURNAL OF HEMATOLOGY, 91(2), 245-251, MAR 2010
  50. Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency, HUMAN GENETICS, 127(6), 619-628, JUN 2010
  51. Recurrent acute cerebellar ataxia associated with anti-cardiolipin antibodies, BRAIN & DEVELOPMENT, 32(7), 588-591, AUG 2010
  52. Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(50), 21529-21534, DEC 14 2010
  53. Identification of therapy-sensitive and therapy-resistant neuroblastoma subtypes in stages III, IVs and IV, CANCER LETTERS, 306(1), 27-33, JUL 1 2011
  54. Clinical and Host Genetic Characteristics of Mendelian Susceptibility to Mycobacterial Diseases in Japan, JOURNAL OF CLINICAL IMMUNOLOGY, 31(3), 309-314, JUN 2011
  55. Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis, JOURNAL OF EXPERIMENTAL MEDICINE, 208(8), 1635-1648, AUG 1 2011
  56. Association of viral isolates from stool samples with intussusception in children, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 15(9), E641-E645, SEP 2011
  57. A Case of Neonatal Coxsackie B2 Meningo-Encephalitis in which Serial Magnetic Resonance Imaging Findings Reveal the Development of Lesions, NEUROPEDIATRICS, 42(4), 156-158, AUG 2011
  58. Decreased Expression in Nuclear Factor-kappa B Essential Modulator Due to a Novel Splice-Site Mutation Causes X-linked Ectodermal Dysplasia with Immunodeficiency, JOURNAL OF CLINICAL IMMUNOLOGY, 31(5), 762-772, OCT 2011
  59. Nationwide Survey of Patients with Primary Immunodeficiency Diseases in Japan, JOURNAL OF CLINICAL IMMUNOLOGY, 31(6), 968-976, DEC 2011
  60. Evaluation of cerebellar mutism by arterial spin-labeling perfusion magnetic resonance imaging in a patient with atypical teratoid/rhabdoid tumor (AT/RT): a case report, CHILDS NERVOUS SYSTEM, 28(8), 1257-1260, AUG 2012
  61. Endocrine complications in primary immunodeficiency diseases in Japan, CLINICAL ENDOCRINOLOGY, 77(4), 628-634, OCT 2012
  62. Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(8), 3023-3028, FEB 19 2013
  63. Reduced brain activation during imitation and observation of others in children with pervasive developmental disorder: a pilot study, BEHAVIORAL AND BRAIN FUNCTIONS, 9, MAY 29 2013
  64. Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 400-+, AUG 2013
  65. Management of advanced-stage neuroblastoma in a patient with 21-hydroxalase deficiency, PEDIATRICS INTERNATIONAL, 55(4), E96-E99, AUG 2013
  66. Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells, JOURNAL OF EXPERIMENTAL MEDICINE, 210(12), 2739-2753, NOV 18 2013
  67. IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts, BLOOD, 122(24), 3940-3950, DEC 5 2013
  68. Ictal Electroencephalography and Electromyography Features in Symptomatic Infantile Epileptic Encephalopathy with Late-Onset Spasms, NEUROPEDIATRICS, 45(1), 36-41, FEB 2014
  69. Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis, JOURNAL OF LEUKOCYTE BIOLOGY, 95(4), 667-676, APR 2014
  70. Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis, HAEMATOLOGICA, 99(1), 19-27, JAN 2014
  71. A Pediatric Case of Peripheral Polyneuropathy With IgM anti-GM1 Antibody Associated With a Group A Beta-Hemolytic Streptococcus Infection, PEDIATRIC NEUROLOGY, 51(3), 441-443, SEP 2014
  72. Gene Alterations Involving the CRLF2-JAK Pathway and Recurrent Gene Deletions in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan, GENES CHROMOSOMES & CANCER, 53(11), 902-910, NOV 2014
  73. Compound heterozygosity in GPR56 with bilateral frontoparietal polymicrogyria, BRAIN & DEVELOPMENT, 36(6), 528-531, JUN 2014
  74. Increased interleukin-6 and high-sensitivity C-reactive protein levels in pediatric epilepsy patients with frequent, refractory generalized motor seizures, SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 25, 136-140, FEB 2015
  75. The International Immune Tolerance Induction Study and its follow-up study on Japanese hemophilia A patients with inhibitors, INTERNATIONAL JOURNAL OF HEMATOLOGY, 101(4), 362-368, APR 2015
  76. The postirradiation incidence of cavernous angioma is higher in patients with childhood pineoblastoma or primitive neuroectodermal tumors than medulloblastoma, CHILDS NERVOUS SYSTEM, 31(6), 901-907, JUN 2015
  77. STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function, JOURNAL OF EXPERIMENTAL MEDICINE, 212(6), 855-864, JUN 1 2015
  78. Mosaicism of an ELANE Mutation in an Asymptomatic Mother in a Familial Case of Cyclic Neutropenia, JOURNAL OF CLINICAL IMMUNOLOGY, 35(5), 512-516, JUL 2015
  79. IMMUNODEFICIENCIES Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations, SCIENCE, 349(6248), 606-613, AUG 7 2015
  80. Perceived Parenting Mediates Serotonin Transporter Gene (5-HTTLPR) and Neural System Function during Facial Recognition: A Pilot Study, PLOS ONE, 10(9), SEP 29 2015
  81. Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(4), 993-+, OCT 2015
  82. Remission of autoimmune neutropenia after development of Kawasaki disease, PEDIATRICS INTERNATIONAL, 57(5), 1012-1014, OCT 2015
  83. Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia, HAEMATOLOGICA, 100(12), 1546-1552, NOV 2015
  84. Late-onset epileptic spasms in a patient with 22q13.3 deletion syndrome, BRAIN & DEVELOPMENT, 38(1), 109-112, JAN 2016
  85. A Patient with CTLA-4 Haploinsufficiency Presenting Gastric Cancer, JOURNAL OF CLINICAL IMMUNOLOGY, 36(1), 28-32, JAN 2016
  86. Cavernous angioma after chemotherapy for desmoplastic/nodular medulloblastoma associated with anhidrotic ectodermal dysplasia, CHILDS NERVOUS SYSTEM, 32(2), 395-398, FEB 2016
  87. Early eradication of factor VIII inhibitor in patients with congenital hemophilia a by immune tolrelance induction with a high dose of immunoglobulin, International Journal of Hematology
  88. Significance of ACADM mutations identified through newborn screening of MCAD deficiency in Japan, MOLECULAR GENETICS AND METABOLISM, 118(1), 9-14, MAY 2016
  89. Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype, BLOOD, 127(25), 3154-3164, JUN 23 2016
  90. Effective Treatment of a Childhood Blastic Plasmacytoid Dendritic Cell Neoplasm with a Cutaneous Tumor Alone by Stem Cell Transplantation with Reduced Intensity Conditioning, INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 32, S26-S31, JUN 2016
  91. Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4(+) T cells into distinct effector subsets, JOURNAL OF EXPERIMENTAL MEDICINE, 213(8), 1589-1608, JUL 25 2016

External Funds

Acceptance Results of Competitive Funds

  1. Practical Research for Innovative Cancer Control, 2015/04/01, 2016/03/31
  2. Research on Development of New Drugs, 2015/11/02, 2016/03/31
  3. Practical Research Project for Rare / Intractable Diseases, 2015/04/01, 2016/03/31
  4. Practical Research Project for Allergic Diseases and Immunology (Research on Technology of Medical Transplantation), 2015/04/01, 2016/03/31
  5. 2000
  6. 1997
  7. 2008
  8. 2011
  9. 2010
  10. 2010
  11. 2010
  12. 2005
  13. 2010
  14. 2012
  15. 2011
  16. 2012
  17. KAKENHI, 2014, 2015
  18. KAKENHI, 2013, 2015
  19. KAKENHI, Application of humanized mice to analyses and therapeutics of phagocytic disorders, 2010, 2012
  20. KAKENHI, The cell-surface modification enhances the engraftment of human CD34-positive cells into immunodeficient mice, 2007, 2008
  21. KAKENHI, Basic research for the establishment of the intra-bone marrow stem cell transplantation, 2004, 2005
  22. KAKENHI, Purification, expansion, and reconstitution of mesodermal stemcells from human bone marrow, 2003, 2004
  23. KAKENHI, GENE EXPRESSIONS DURING PROLIFERATION AND DIFFERENTIATION OF MYELOID CELIS IN SEVERE CONCENITAL NEUTROPENIA, 2001, 2002
  24. KAKENHI, Identification of Human facilitating cells, 2001, 2002
  25. KAKENHI, A study for a transcription factor gene regulating radiation sensitivity, 1999, 2000
  26. KAKENHI, EXPANSION OF HUMAN BONE MARROW CELLS CAPABLE OF REPOPULATING IN MICE BY COCULTURE WITH BONE MARROW STROMAL CELLS, 1999, 2000
  27. KAKENHI, CHARACTERIZATION OF PURIFIED HUMAN HEMATOPOIETIC PROGENITOR CELLS OF BONE MARROW AND THEIR RECONSTITUTING ABILITY IN GENOGENEIC TRANSPLANTATION, 1997, 1998
  28. KAKENHI, 1993, 1993
  29. KAKENHI, 1990, 1990
  30. KAKENHI, 1989, 1989
  31. KAKENHI, 1986, 1986
  32. Health and Labour Sciences Research Grants, 2014/05/29, 2015/03/31
  33. Health and Labour Sciences Research Grants, 2014/06/02, 2015/03/31
  34. Health and Labour Sciences Research Grants, 2014/06/02, 2015/03/31