Nariaki Fujimoto

Last Updated :2020/09/01

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Associate Professor

Basic Information

Academic Degrees

  • Ph.D., Hiroshima University
  • Master, Hiroshima University

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Medicine,dentistry, and pharmacy;Clinical surgery;Urology
  • Biology;Biological Science;Functional biochemistry

Research Keywords

  • Tumor growth|Prostate cancer
  • Developmental and regenerative biology|thyroid hormones
  • hypothalamus-pituitary-thyroid axis
  • Estrogen
  • Pituitary
  • thyroid hyperplasia
  • EDCs
  • Low-dose effects
  • Estrogen

Affiliated Academic Societies

  • The Japan Endocrine Society
  • The European Society of Endocrinology
  • Japan Hormonal Steroid Society
  • Japanese Society of Toxicologic Pathology
  • The Japan Society of Endocrine Disrupters Research

Research Activities

Academic Papers

  1. Study of metablic activation of the UV-filter octyl methoxycinnamate for endocrine-disrupting activity, Fundamental Toxicological Sciences, 5(6), 185-193, 20181218
  2. Identification of hepatic thyroid hormone-responsive genes in neonatal rats: Potential targets for thyroid hormone-disrupting chemicals, TOXICOLOGY LETTERS, 286, 48-53, 201804
  3. Irradiation of rats by neutron activated 56Mn dioxide powder and its effects on rats locomotor acitivities, Hiroshima Igaku, 71(4), 373-376, 201804
  4. Altered expression of the Olr59, Ethe1, and Slc10a2 genes in the liver of F344 rats by neonatal thyroid hormone disruption, JOURNAL OF APPLIED TOXICOLOGY, 37(9), 1030-1035, 201709
  5. Internal exposure to neutron-activated Mn-56 dioxide powder in Wistar rats: part 1: dosimetry, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 56(1), 47-54, 201703
  6. Internal exposure to neutron-activated Mn-56 dioxide powder in Wistar rats-Part 2: pathological effects, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 56(1), 55-61, 201703
  7. Increase in prostate stem cell antigen expression in prostatic hyperplasia induced by testosterone and 17 beta-estradiol in C57BL mice, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 158, 56-62, 201604
  8. In vitro metabolism of methiocarb and carbaryl in rats, and its effect on their estrogenic and antiandrogenic activities, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 41, 289-297, 201601
  9. Irradiation of laboratory animals by neutron activated dust: development and application of the method - first results of international multicenter study, Radiation and Risk, 25(4), 111-125, 2016
  10. Changes in plasma triiodothyronine, thyroxine, and thyroid-stimulating hormone after 131I irradiation of newborn rats fed with iodine deficient diet, Science and Health, 2016-3, 26-33, 2016
  11. In vitro metabolism of cis- and trans-permethrin by rat liver microsomes, and its effect on estrogenic and anti-androgenic activities, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 37(3), 996-1005, 201405
  12. Cell type-dependent agonist/antagonist activities of polybrominated diphenyl ethers, TOXICOLOGY LETTERS, 223(2), 192-197, 20131125
  13. Neonatal exposure to 2,337,8-tetrachlorodibenze-p-dioxin increases the mRNA expression of prostatic proteins in C57BL mice, JOURNAL OF TOXICOLOGICAL SCIENCES, 38(2), 279-283, 201304
  14. Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats, JOURNAL OF TOXICOLOGICAL SCIENCES, 37(2), 281-286, 201204
  15. An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide, TOXICOLOGY LETTERS, 208(1), 30-35, 20120105
  16. Androgen dependent transcription of a mouse prostatic protein gene, PSP94: involvement of estrogen receptors, The Journal of Steroid Bio-chemistry and Molecular Biology, 127, 301-306, 20111101
  17. Identification of rat prostatic secreted proteins using mass spectrometric analysis and androgen-dependent mRNA expression, Journal of Andrology, 30, 669, 20091101
  18. Affinity for Thyroid Hormone and Estrogen Receptors of Hydroxylated Polybrominated Diphenyl Ethers, Journal of Health Science, 54, 607, 20081001
  19. Metabolic activation of proestrogens in the environment by cytochrome P450 system., J. Health Sci., 54(5), 343-355, 20080501
  20. Effects of environmental antiandrogenic chemicals on expression of androgen-responsive genes in rat prostate lobes., J. Health Sci., 53, 401-405, 20070625
  21. Quantative determination of lobe specificity of mRNA expression of androgen-dependent genes in the rat prostate gland., Endcrinol. J., 54(1), 123-132, 20070405
  22. PSPC1, NONO, and SFPQ are expressed in mouse Sertoli cells and may function as coregulators of androgen receptor-mediated transcription., Biol Reprod, 75(3), 352-359, 20060901
  23. Identification of prostatic-secreted proteins in mice by mass spectrometric analysis and evaluation of lobe-specific and androgen-dependent mRNA expression, JOURNAL OF ENDOCRINOLOGY, 190(3), 793-803, 200609
  24. Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites, DRUG METABOLISM AND DISPOSITION, 33(8), 1115-1123, 200508
  25. Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds, TOXICOLOGICAL SCIENCES, 84(2), 249-259, 200504
  26. Thyroid hormone-like and estrogenic activity of hydroxylated PCBs in cell culture, TOXICOLOGY, 208(3), 377-387, 20050330
  27. Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis, LIFE SCIENCES, 76(14), 1589-1601, 20050218
  28. Estrogenic and antiandrogenic activities of 17 benzophenone derivatives used as UV stabilizers and sunscreens, TOXICOLOGY AND APPLIED PHARMACOLOGY, 203(1), 9-17, 20050215
  29. Cloning and characterization of the 5 '-flanking region of the rat estrogen receptor beta gene, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 94(1-3), 15-21, 200502
  30. Estrogen enhancement of androgen-responsive gene expression in hormone-induced hyperplasia in the ventral prostate of F344 rats, CANCER SCIENCE, 95(9), 711-715, 200409
  31. Identification of estrogen-responsive genes in the GH3 cell line by cDNA microarray analysis, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 91(3), 121-129, 200407
  32. Activation of estrogen response element dependent transcription by thyroid hormone with increase in estrogen receptor levels in a rat pituitary cell line, GH3, JOURNAL OF ENDOCRINOLOGY, 181(1), 77-83, 200404
  33. Potent estrogenic metabolites of bisphenol A and bisphenol B formed by rat liver S9 fraction: Their structures and estrogenic potency, TOXICOLOGICAL SCIENCES, 78(1), 50-59, 200403
  34. Estrogenic activity of an antioxidant, nordihydroguaiaretic acid (NDGA), LIFE SCIENCES, 74(11), 1417-1425, 20040130
  35. Effects of environmental estrogenic chemicals on AP1 mediated transcription with estrogen receptors alpha and beta, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 88(1), 53-59, 200401
  36. Effects of environmental estrogenic compounds on growth of a transplanted estrogen responsive pituitary tumor cell line in rats, Food Chem. Toxicol. , 41(12), 1711-1717, 200312
  37. Estrogenic activity of stilbene derivatives, J. Health Sci., 49(5), 359-367, 200310
  38. Metabolic activation of proestrogenic diphenyl and related compounds by rat liver microsomes, J. Health Sci., 49(4), 298-310, 200308
  39. Estrogenic activity of an environmental pollutant, 2-nitrofluorene, after metabolic activation by rat liver microsomes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 303(2), 419-426, 20030404
  40. Estrogenic Activity of Styrene Oligomers after Metabolic Activation by Rat Liver Microsomes, Env. Health Persp, 111(3), 329-334, 20030401
  41. Antiandrogenic activity and metabolism of the organophosphorus pesticide fenthion and related compounds, Env. Health Persp, 111(4), 503-508, 200304
  42. Tumorigenesis in infant C3H/HeN mice exposed to tritiated water (HTO), J. Radiation Res., 43(4), 345-351, 200212
  43. Iron lactate induction of pancreatic and endometrial proliferative lesions and a lack of increased tumors in a 104-week carcinogenicity study in F344 rats, Food Chem. Toxicol. , 40(10), 1441-1448, 200210
  44. Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol, Biochem. Biophys. Res. Commun., 239, 554-559, 20020401
  45. Tumorigenesis in infant C3H/HeN mice exposed to tritiated water (HTO), J. Radiat. Res., 43, 345-351, 20020401
  46. Age-dependent exposure to radioactive iodine (I-131) in the thyroid and total body of newborn, pubertal and adult Fischer 344 rats, J. Radiation Res., 42(2), 143-155, 200106
  47. Dose-threshold for thyroid tumor-promoting effects of orally administered kojic acid in rats after initiation with N-bis(2-hydroxypropyl) nitrosamine., J Toxicol Sci., 26(2), 85-94, 20010401
  48. Effects of endocrine disruptors on the pituitary gland., J. Toxicol. Pathol., 14, 65-69, 20010401
  49. Strain Difference in Regulation of Pituitary Tumor Transforming Gene (PTTG) in Estrogen Induced Pituitary Tumorigenesis in Rats, Jpn.J.Cancer Res., 92(10), 1034-1040, 20010401
  50. Suppression by estrogen receptor beta of AP-1 mediated transactivation through estrogen receptor alpha, J. Steroid Biochem. Mol. Biol., 78(7-8), 177-184, 20010401
  51. Sex hormone dependency of diethylnitrosamine-induced liver tumors in mice and chemoprevention by leuprorelin, Jpn.J.Cancer Res., 92(3), 249-256, 200103
  52. Expression of estrogen receptor alpha and beta mRNAs in prostate cancers treated with leuprorelin acetate, Euro.Urol., 38, 635-639, 20000401
  53. Establishment of an estrogen responsive rat pituitary cell sub-line MtT/E-2, Endocrine J., 46, 389-396, 19990401
  54. Gastric tumor induction by 1,2-dimethylhydrazine in Wistar rats with intestinal metaplasia caused by X-irradiation., Jpn.J.Cancer Res., 90, 1207-1211, 19990401
  55. Growth stimulation of a rat pituitary cell line MtT/E-2 by environmental estrogens in vitro and in vivo, Endocrine J., 46, 531-538, 19990401
  56. Influence of concomitant miso or NaCl treatment on induction of gastric tumors by N-methyl-N’-nitro-N-nitrosoguanidine in rats., Oncol.Rep., 6(5), 989-993, 19990401
  57. Inhibition of thyroid iodine uptake and organification in rats treated with kojic acid., Toxicol. Sci., 47, 170-175, 19990401
  58. Induction of ovarian tumors by heavy ion irradiation in B6C3F1 mice., Oncol.Rep., 5, 1377-1380, 19980401
  59. Induction of thyroid tumours in(C57BL/6NxC3H/N)F1 mice by oral administration of kojicacid, Food Chem. Toxicol. , 36, 697-703, 19980401
  60. No susceptibility of colon tissue implanted into the glandular stomach of rats to N-nitroso-N-methylurea carcinogenesis., Oncol.Rep., 5(6), 1373-1376, 19980401
  61. Oral administration of tritiated water (HTO) in mouse. III: Low dose-rate irradiation and threshold dose-rate for radiation risk., Int J Radiat Biol, 73, 535-541, 19980401
  62. Up-regulation of the estrogen receptor by triiodothyronine in rats pituitary cell line., J. Steroid Biochem. Molec. Biol., 61, 79-85, 19970401
  63. Reduction of gastric tumors by administration with reduced salt Miso diet during N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) treatment in rats., Miso Sci. Technol., 45, 107-115, 19970401
  64. Up-regulation on the estrogen receptor by triiodothyronine in rat pituitary cell lines, J. Steroid Biochem. Molec. Biol., 61, 79-85, 19970401
  65. Blockade of the estrogen induced increase in progesterone receptor caused by propylthiouracil, an anti-thyroid drug, in a transplantable pituitary tumor in rats., Endocrine J., 43, 329-334, 19960401
  66. Enhancing effects of immunization with rectal extract on rectal carcinogenesis by local X-irradiation caused in male A/HeJ mice., Onco. Rep., 3, 707-712, 19960401
  67. Gastric tumorigenicity of 1,2-dimethylhydrazine on the background of gastric intestinal metaplasia induced by X-irradiation in CD(SD) rats., Jpn.J.Cancer Res., 87, 433-436, 19960401
  68. Influence of paternal 252-Cf neutron exposure on abnormal sperms, embryonal lethality, and liver tumorigenesis in the F1 offsprings of mice., Jpn.J.Cancer Res., 87, 51-57, 19960401
  69. Promotion of thyroid tumors in F344 male rats given a low iodine diet after treatment with N-methyl-N-nitrosourea in their drinking water., J. Toxico. Pathol., 9, 191-197, 19960401
  70. Antiestrogens: Mechanisms and actions in target cells., J. Steroid Biochem. Molec. Biol., 53, 387-393, 19950401
  71. Elevated serum growth hormone accelerates gastric tumorigenesis in F344 rats after treatment with N-methyl-N-nitrosourea in their drinking water., Jpn.J.Cancer Res., 86, 631-637, 19950401
  72. Estrogen and carcinogenesis, J. Toxic. Path., 8, 285-289, 19950401
  73. Alteration in the agonist/antagonist balance of antiestrogens by activation of protein kinase A signaling pathways in breast cancer cells : Antiestrogen selectivity and promoter dependence, Molecular Endocrinology, 8, 296-304, 19940401
  74. Chronic toxicity study of Gardenia yellow color in C57BL mice., J. Toxic. Path., 7, 455-460, 19940401
  75. Inhibition of mammary tumors by pretreatment with 17beta-estradiol in F344 rats induced with N-methyl-N-nitrosourea., Jpn.J.Cancer Res., 84, 279-283, 19940401
  76. Tumorigenicity study of phloxine (FR 104) in B63F1 mice., Fd Chem. Toxic., 32, 517-520, 19930401
  77. Increase in estrogen receptor levels in MNV-induced thyroid tumors in LE rats, Carcinogenesis, 13(8), 1315-1318, 19920401
  78. Direct up-regulation of estrogen receptor by triiodothyronine in rat pituitary tumor M+T/F84,, Endocrinologica Japonica, 38(4), 405-412, 19910401
  79. Estrogen dependent growth of a rat pituitary tumor (MtT/F84), Chem. Carcinogenesis, 2, 264-270, 19910401
  80. Estrogen receptor levels and tumor growth in a series of pituitary clonal cell lines in rats., Jpn.J.Cancer Res., 82, 1436-1441, 19910401
  81. Photodynamic therapy for rat pituitary tumor in vitro and in vivo using pheophorbide-a and white light, Lasers Surg., 11, 174-182, 19910401
  82. Stimulatory effects of retinoic acid on tumor growth and serum insulin-like growth factor-1 in rats bearing estrogen responsive pituitary tumor MtT/Se., Jpn.J.Cancer Res., 82, 815-819, 19910401
  83. Establishment of a series of pituitary clonal cell lines differing in morphology, hormone secretion, and response to estrogen., Endocrinology, 126, 2313-2320, 19900401
  84. Growth promoting effect of retinoic acid in transplantable pituitary tumor of rat., Jpn.J.Cancer Res., 81, 878-883, 19900401
  85. Promoting action of prolactin released from a grafted transplantable pituitary tumor (MtT/F84) on rat prostate carcinogenesis., Cancer Letters, 53, 151-157, 19900401
  86. Effects of sex difference, gonadectomy and estradiol on N-ethyl-N- nitrosourea-induced trigeminal nerve tumors in rats, Carcinogenesis, 10, 1505-1509, 19890401
  87. Increase of estrogen receptor level by thyroxin in estrogen dependent pituitary tumor (MtT/F84) in rats., Biochem. Biophys. Res. Comm., 152, 44-48, 19880401
  88. Inhibition by 2-bromo-alpha-ergocriptine on the proliferation of an mono-dispersed MtT/F84 cells inoculated in 17beta-estradiol treated rats., Proc. Hiroshima Univ. RINMB ll : l52-l65= l970., 28, 211-217, 19870401
  89. Induction of thyroid tumors in (C57BL/6NxC3H/N)F1 mice by oral administration of 9-3’, 4’, 5’, 6’-tetrachloro-o-carboxy phenyl-6-hydroxy-2,4,5,7-tetraiodo-3-isoxanthone sodium (food red 105, Rose Bengal B), JNCI, 77, 277-281, 19860401
  90. Inhibition by 2-bromo-alpha-ergocriptine and tamoxifen of the growth of an estrogen-dependent transplantable pituitary tumor(MtT/F84) in F344 rats., Cancer Res., 45, 6436-6441, 19850401
  91. Amino acid sequence of a ferredoxin from thermoacidophilic archaebacteria, Thermoplasma acidophulum., FEBS Letters, 162, 21-24, 19830401

Invited Lecture, Oral Presentation, Poster Presentation

  1. Effects of exposure to radioactive 56MnO2 powder on the gene expression in the lung and the liver of rats, Fujimoto N, Kairkhanova Y, Saimova A, Uzbekov D, Chaizhunusova N, Shichijo K, Nakashima M, Rakhypbekov T, Hoshi M, The 21st Hiroshima International Symposium, 2018/01/28, With Invitation, HISOC, Hiroshima University, Hiroshima
  2. Effects of exposure to radioactive 56MnO2 powder on the gene expression of liver in rats, Nariaki Fujmoto, Ynkar Kairkhanova, Aisulu Saimova, Darkhan Uzbekov, Nailya Chaizhunusova, Kazuko Shichijo, Masahiro Nakashima, Tolebay Rakhypbekov, Masaharu Hoshi, The 5th Shimane Semey International Symposium, 2018/01/25, With Invitation, Shiname University, Izumo, Shimane
  3. The thyroid gland in rats neonatally exposed to ionized radiation, Nariaki FUJIMOTO, Mutsumi Matsuu-Matsuyama, Masahiro Nakashima, The 59th ABC, 2018/06/03, Without Invitation, Nagasaki
  4. Internal exposure to radioactive 56Mn dioxide powder in rats - Effects on gene expressions, Nariaki Fujimoto, Ynkar Kairkhanova, Aisulu Saimova, Darkhan Uzbekov, Nailya Chaizhunusova, Kazuko Shichijo, Masahiro Nakashima, Tolebay Rakhypbekov, Valeriy Stepanenko, Masaharu Hoshi, The XIII International Research and Practical conference "Ecology. Health. Radiation", 2017/08/29, With Invitation, Semey State Medical University, Kazakhstan, Semey State Medical University, Kazakhstan
  5. Changes in radiation injury related mRNA expression in the lung of rats exposed to radioactive 56MnO2 powder, Nariaki FUJIMOTO, Ynkar Kairkhanova, Aisulu Saimova, Darkhan Uzbekov, Nailya Chaizhunusova, Kazuko Shichijo, Masahiro Nakashima, Tolebay Rakhypbekov, Masaharu Hoshi, The 4th Shimane-Semey International Symposium, 2017/01/26, With Invitation, Shimane University, Izumo, Shimane
  6. Changes in lung injury related mRNA expression in rats exposed to neutron-activated 56Mn powder, Nariaki FUJIMOTO, Ynkar Kairkhanova, Aisulu Saimova, Darkhan Uzbekov, Nailya Chaizhunusova, Kazuko Shichijo, Masahiro Nakashima, Tolebay Rakhypbekov, Masaharu Hoshi, Workshop: Mn-56 experiments and the results -Possibility of the small particle effects-, 2016/12/09, With Invitation, IPS, Hiroshima University, Hiroshima
  7. Hepatic Thyroid Hormone Responsive Genes in Rat Neonates - Potential Targets for Thyroid Hormone Disrupting Chemicals, Nariaki Fujimoto, Shinichi Miyagawa, Taisen Iguchi, NIBB conference, Environment to Bioresponse., Without Invitation, National Institute for Basic Biology, Okazaki, Aichi-ken
  8. Changes in lung injury related mRNA expression in rats exposed to neutron-activated Mn-56 powder, Fujimoto, N., Kairkhanova Y., Saimova A., Uzbekov D., Chaizhunusova N., Sichijo K., Nakajima M., Rakhypbekov T., Hoshi M., The 39th annual meeting of Molecular Biology Society of Japan, 2016/11/30, Without Invitation, Molecular Biology Society of Japan, Yokohama
  9. Increase in PSCA expression in prostatic hyperplasia induced by testosterone and estradiol in mice, Nariaki Fujimoto, Jun Kanno, The 23rd meeting of Japan Hormonal Steroid Society, 2016/01/15, Without Invitation, Japan Hormonal Steroid Society, Kurashiki, Hiroshima
  10. Prostatic hyperplasia induced by testosterone and 17beta-estradiol in C57BL mice, Nariaki FUJIMOTO, Jun Kanno, The 88th Annual Meeting of the Japanese Endocrine Society, 2015/04/24, Without Invitation, he Japanese Endocrine Society, Tokyo
  11. Short-term effects of neonatal exposure of OH-PBDEs on thyroid hormone responsive gene expression in the liver in F344 rats, Fujimoto, N., Nakamura, N., Sanoh, S., Ohta, S., Uramaru, N., Kitamura, S., Miyagawa, S., Iguchi, T., 17th Annual Meeting of JSEDR, 2014/12/09, Without Invitation, JSEDR, Tokyo
  12. Thyroid hormone activity of PBDEs in vitro and in vivo, Fujimoto, N., Nakamura, N., Sanoh, S., Ohta, S., Kitamura, S, 15th Asia Oceania Congress of Endocrinology, 2014/10/10, Without Invitation, Philippine Society of Endocrinology and Metabolism, Cebu, Philippines
  13. Histological and functional changes in the thyroid in rats neonatally exposed to X-rays, Fujimoto,N, Matsuu-Matsuyama,M, Nakashima,M, The 35th Annual Meeting of the Japanese Society of Toxicologic Pathology, 2019/01/31, Without Invitation
  14. Functional changes in neonatally X-irradiated thyroid gland in rats, Fujimoto,N, Matsuu-Matsuyama,M, Nakashima,M, The 92nd Annual Meeting of the Japan Endocrine Society, 2019/05/10, Without Invitation
  15. Pathology and gene expression changes in the lung of rats exposed to 56MnO2 powders, Fujimoto,N, The 22nd Hiroshima International Symposium International Research Meeting for Studies of Biological Effects of Radioactive Microparticles in Kazakh, Russia & Japan, 2019/02/28, With Invitation


  1. 2003, Best Paper Award 2003 in Journal of Health Science
  2. 2013, Best Poster Award, ISPROF 2013

Social Activities

History as Committee Members

  1. commission member, 2005/04, 2016/03, Food Safety Commission, Cabinet Office
  2. Expert, 2016/04, 2018/03

History as Peer Reviews of Academic Papers

  1. 2018, General and Comparative Endocrinology, Reviewer, 1