RIKU KAWASAKI

Last Updated :2024/04/04

Affiliations, Positions
Graduate School of Advanced Science and Engineering, Associate Professor
Web Site
https://ikedalab.wixsite.com/mysite
E-mail
riku0528hiroshima-u.ac.jp
Self-introduction
I have mainly studied functional biomaterials based on supramolecular chemistry. Especially, I developed drug delivery system with hydrophobized polysaccharide for cancer therapy, protein delivery and bio-imaging.

Basic Information

Major Professional Backgrounds

  • 2017/04, 2017/08, Graduated School of Engineering, Kyoto University, Post-doctoral Researcher
  • 2017/09, 2018/08, University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Science, Post-doctoral researcher
  • 2018/09, 2019/09, RIKEN, Post-doctoral Researcher
  • 2019/10/01, 2020/03/31, Hiroshima University, Graduated School of Engineering, Assistant Professor

Educational Backgrounds

  • Kyoto University, Engineering, Polymer Chemistry, Japan, 2014/04, 2017/03
  • Osaka City University, Engineering, Applied Chemistry and Biochemistry, Japan, 2012/04, 2014/03
  • Osaka City University, Engineering, Bioengineering, Japan, 2008/04, 2012/03

Academic Degrees

  • Osaka City University
  • Kyoto University

Research Fields

  • Complex systems;Biomedical engineering;Biomedical engineering / Biomaterial science and engineering

Research Keywords

  • Supramolecular Chemistry, Self-assembly, Nanoparticle, Hydrogel, Biomaterial, Drug Delivery System, Regenerative medicine, Organic-inorganic hybrid material, Bioimaging contrast agent, Biomedical engineering, Biopharmaceutics, polysaccharide, Exosome

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, General Chemistry
  2. 2024, Undergraduate Education, 1Term, Analytical Chemistry
  3. 2024, Undergraduate Education, 4Term, Exercises in Organic Chemistry
  4. 2024, Undergraduate Education, First Semester, Chemical Experiments I
  5. 2024, Undergraduate Education, 3Term, Quantum Chemistry III
  6. 2024, Undergraduate Education, Year, Graduation Thesis
  7. 2024, Graduate Education (Master's Program) , 1Term, Special Exercises on Applied Chemistry A
  8. 2024, Graduate Education (Master's Program) , 2Term, Special Exercises on Applied Chemistry A
  9. 2024, Graduate Education (Master's Program) , 3Term, Special Exercises on Applied Chemistry B
  10. 2024, Graduate Education (Master's Program) , 4Term, Special Exercises on Applied Chemistry B
  11. 2024, Graduate Education (Master's Program) , Academic Year, Special Study on Applied Chemistry
  12. 2024, Graduate Education (Master's Program) , 2Term, Biomaterial Engineering

Research Activities

Academic Papers

  1. Aqueous Solutions of a Porous Host–Poly-L-lysine Complex with Information on Solids as Different Fluorescence by Guests, Chemistry an Asian Journal, e20220879, 1-4, 20220927
  2. Formulation of water-dispersible hydrophobic compound nanocomplexes with polypeptides via a supramolecular approach using a high-speed vibration milling technique, RSC Advances, 12, 32012-32019, 20221108
  3. Cyclodextrin-induced release of drug-entrapping liposomes associated with the solation of liposome gels, RSC ADVANCES, 12(34), 22202-22209, 20220804
    Link to Paper Search Results by DOI
  4. Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(9), 202205
    Link to Paper Search Results by DOI
  5. Effect of meso Positioned Substituents on the Stability and Photodynamic Activity of Lipid-Membrane-Incorporated Porphyrin Derivatives, CHEMMEDCHEM, 17(9), 20220504
    Link to Paper Search Results by DOI
  6. Improvement of Photodynamic Activity by a Stable System Consisting of a C-60 Derivative and Photoantenna in Liposomes br, ACS MEDICINAL CHEMISTRY LETTERS, 13(4), 641-647, 20220414
    Link to Paper Search Results by DOI
  7. Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy, Int. J. Mol. Sci., 23, 4686, 2022
  8. Effect of meso Positioned Substituents on the Stability and Photodynamic Activity of Lipid-Membrane Incorporated Porphyrin Derivatives, ChemMedChem, 17(e202200070), 2022
  9. 25) Improvement of Photodynamic Activity by a Stable System Consisting of a C60 Derivative and Photo-Antenna in Liposome, ACS Med. Chem. Lett., 13, 641-647, 2022
  10. ★, Magnetically guided protein transduction by hybrid nanogel chaperones with iron oxide nanoparticles, Angewandte Chemie International Edition, 128, 11377-11381, 2016
  11. ★, Intracellular delivery and passive tumor targeting of a self-assembled nanogel containing clusters for boron neutron capture therapy, Biochemical and Biophysical Research Communications, 483, 147-152, 2017
  12. ★, Calcium-deficient hydroxyapatite as a potential sorbent for strontium, Scientific Reports, 7, 2064, 2017
  13. ★, Magnetically navigated intracellular delivery of extracellular vesicles using amphiphilic nanogels, Bioconjugate Chemistry, 30, 2150-2154, 2019
  14. Nanogel hybrid assembly for exosome intracellular delivery: effects on endocytosis and fusion by exosome surface polymer engineering, Biomaterials Science, 2, 619-630, 2020
    Link to Paper Search Results by DOI
  15. Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in Beta-(1,3-1,6)-D-Glucan with On-Off Switch, Chemistry An Asian Journal, 15, 365-370, 2020
    Link to Paper Search Results by DOI
  16. Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in beta-(1,3-1,6)-d-Glucan with On-Off Switch, CHEMISTRY-AN ASIAN JOURNAL, 15(3), 365-370, 20200203
    Link to Paper Search Results by DOI
  17. Aggregation-Induced Emission and Retention of Crystal Chiral Information of Tetraphenylethylene Incorporated by Polysaccharides in Water, CHEMPHOTOCHEM, 4(8), 577-581, 202008
    Link to Paper Search Results by DOI
  18. Improved water solubility and photodynamic activity of hydroxy-modified porphyrins by complexation with cyclodextrin, ORGANIC & BIOMOLECULAR CHEMISTRY, 18(34), 6702-6709, 20200914
    Link to Paper Search Results by DOI
  19. Hydrogen Sulfide-Responsive Self-Assembled Nanogel, ACS APPLIED POLYMER MATERIALS, 2(9), 3756-3760, 20200911
    Link to Paper Search Results by DOI
  20. Water Solubilization of Phthalocyanine Derivatives via Interactions of Long Alkyl Chains and Cyclodextrins: Potential Complexes for Photodynamic Therapy, ASIAN JOURNAL OF ORGANIC CHEMISTRY, 9(10), 1589-1596, 202010
    Link to Paper Search Results by DOI
  21. Bacterial elimination via the photodynamic activity of a fullerene/light-harvesting antenna molecule assembled system integrated into liposome membranes, NANOSCALE ADVANCES, 2(10), 4395-4399, 20201001
    Link to Paper Search Results by DOI
  22. Solubilization of Tetrahydroxyphenylchlorin in Water and Improved Photodynamic Activity after Complexation with Cyclic Oligo- and Polysaccharides, ACS APPLIED BIO MATERIALS, 3(5), 3217-3225, 20200518
    Link to Paper Search Results by DOI
  23. Fullerene-porphyrin hybrid nanoparticles that generate activated oxygen by photoirradiation, RSC ADVANCES, 11(3), 1564-1568, 20210113
    Link to Paper Search Results by DOI
  24. Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy, ACS OMEGA, 6(4), 3209-3217, 20210202
    Link to Paper Search Results by DOI
  25. Mechanism toward Turn-on of Polysaccharide-Porphyrin Complexes for Fluorescence Probes and Photosensitizers in Photodynamic Therapy in Living Cells, CHEMMEDCHEM, 16(5), 793-803, 20210303
    Link to Paper Search Results by DOI
  26. ★, Tumor-targeting hyaluronic acid/fluorescent carborane complex for boron neutron capture therapy, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 559, 210-216, 20210625
    Link to Paper Search Results by DOI
  27. ★, Development of Reactive Oxygen Species-Triggered Degradable Nanoparticles Using Oligoproline-containing Peptides, Biomacromolecules, 21, 1589-1596
  28. ★, Magnetically navigated protein transduction in vivo using iron-oxide-nanogel chaperone hybrid, Advanced Healthcare Materials, 10, 2001988, 20210308
  29. ★, Nanoscale polyion complex vesicles for delivery of cargo proteins and Cas9 ribonucleoprotein complexes to plant cells, ACS Applied Nano Materials, 20210603
  30. Development of Reactive Oxygen Species-Triggered Degradable Nanoparticles Using Oligoproline-Containing Peptides, BIOMACROMOLECULES, 21(10), 4116-4122, 202010
    Link to Paper Search Results by DOI
  31. Photodynamic therapy using self-assembled nanogels comprising chlorin e6-bearing pullulan, JOURNAL OF MATERIALS CHEMISTRY B, 9(32), 6357-6363, 20210828
    Link to Paper Search Results by DOI
  32. Preparation of Aqueous Solutions with Information on Solids (ASIS) of a Mechanochromic Luminescent Tetraphenylethylene Derivative by Complexation with Polysaccharides, ACS APPLIED POLYMER MATERIALS, 3(8), 3708-3713, 20210813
    Link to Paper Search Results by DOI
  33. Simple Formation of Cancer Drug-Containing Self-Assembled Hydrogels with Temperature and pH-Responsive Release, LANGMUIR, 37(38), 11269-11275, 20210928
    Link to Paper Search Results by DOI
  34. Photo-triggered cargo release from liposome chlorin e6-bearing pullulan hybrid nanoparticles via membrane permeabilization, RSC ADVANCES, 11(58), 36564-36568, 20211112
    Link to Paper Search Results by DOI
  35. Water solubilization of paclitaxel using polypeptides for cancer therapy, MATERIALS ADVANCES, 3(1), 467-473, 20220104
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Fullerene Nanocrystal-Gold Nanoparticle Hybrid for Theranostic Agent-Based on Photothermal Therapy and Photoacoustic Imaging, R. Kawasaki, K. Kondo, R. Miura, K. Yamana, H. Isozaki, S. Kawamura, T. Nishimura, N. Tarutani, K. Katagiri, S. Sawada, Y. Sasaki, K. Akiyoshi, A. Ikeda, Kyoto University / ERATO International Symposium Chemistry and Plant Biology, 2022/03/15, Without Invitation, Japanese, Kyoto University / JST-ERATO
  2. The Complex of Pyrene-substituted Carborane with Hyaluronic Acid for Tumor-Targeted Boron Neutron Capture Therapy, K. Yamana, R. Kawasaki, Y. Sanada, A. Tabata, K. Bando, K. Yoshikawa, H. Azuma, Y. Sakurai, S. Masunaga, M. Suzuki, K. Suzuki, T. Nagasaki, A. Ikeda, Kyoto University / ERATO International Symposium Chemistry and Plant Biology, 2022/03/15, Without Invitation, English, Kyoto University / JST-ERATO, Kyoto University

Awards

  1. 2014, Excellent Poster Award, Asian Arden Conference
  2. 2016, Bioconjugate Chemistry Award, SPSJ
  3. 2017, Editor's Choice, The Chemistry of Society of Japan

Patented

  1. Patent

External Funds

Acceptance Results of Competitive Funds

  1. 2021/03/01, 2023/02/28
  2. 2021/02/01, 2022/04/30
  3. 2020/10/01, 2021/09/30
  4. 2020/08/01, 2021/03/31
  5. 2020/04, 2021/03
  6. 2020/04, 2021/03
  7. 2019/04, 2022/03
  8. 2017/09, 2018/08