Masaharu Yoshihara

Last Updated :2020/12/01

Affiliations, Positions
Health Service Center, Professor
E-mail
myoshih"At Mark"hiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Complex systems;Health / Sports science;Applied health science
  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Gastroenterology

Research Keywords

  • Gastric Cancer Screening/ Colorectal Cancer Screening
  • Helicobacter pylori/ pepsinogen
  • Health
  • Accessibilty/ Universal Design/ Dysability

Research Activities

Academic Papers

  1. Clinical impact and characteristics of the narrow-band imaging magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team, GASTROINTESTINAL ENDOSCOPY, 85(4), 816-821, APR 2017
  2. Endoscopic findings of the gastric mucosa during long-term use of proton pump inhibitor - a multicenter study, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 52(8), 828-832, 2017
  3. Serological Evaluation of Gastric Cancer Risk Based on Pepsinogen and Helicobacter pylori Antibody: Relationship to Endoscopic Findings, DIGESTION, 95(4), 314-318, 2017
  4. Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study, GASTRIC CANCER, 20(5), 764-771, SEP 2017
  5. Diagnostic performance of Japan NBI Expert Team classification for differentiation among noninvasive, superficially invasive, and deeply invasive colorectal neoplasia, GASTROINTESTINAL ENDOSCOPY, 86(4), 700-709, OCT 2017
  6. Causes of delayed diagnoses of cancers in Japan from the viewpoint of malpractice litigations., Dig Liver Dis, 48(6), 687-8, 2016
  7. A computer system to be used with laser-based endoscopy for q uantitative diagnosis of early gastric cancer., J Clin Gastroenterol , 49(2), 108-15, 2015
  8. Diagnosis of Helicobacter pylori-induced gastritis by serum pepsinogen levels., J Gastroenterol Hepatol., 30(10), 1473-7, 2015
  9. Rate of unintended Helicobacter pylori eradication in the Vietnamese., Helicobacter , 20(2), 1565-7, 2015
  10. The number of criminal prosecutions of physicians for medical negligence related to gastroenterology is on the rise in Japan., Scand J Gastroenterol , 50(5), 619-20, 2015
  11. Time Trends in Helicobacter pylori Infection and Atrophic Gastritis Over 40 Years in Japan., Helicobacter , 20(3), 192-8, 2015
  12. Diagnosis of Helicobacter pylori-induced gastritis by serum pepsinogen levels, J Gastroenterol Hepatol , 30(10), 1473-1477, OCT 2015
  13. Advanced method for evaluation of gastric cancer risk by serum markers: determination of true low-risk subjects for gastric neoplasm., Helicobacter , 19(1), 1-8, 2014
  14. Characteristic epithelium with low-grade atypia appears on the surface of gastric cancer after successful Helicobacter pylori eradication therapy., Helicobacter , 19(4), 289-95, 2014
  15. Characteristics of metachronous gastric tumors after endoscopic submucosal dissection for gastric intraepithelial neoplasms., Gastroenterol Res Pract , 2014
  16. Predictors of incomplete resection and perforation associated with endoscopic submucosal dissection for colorectal tumors., Gastrointest Endosc , 79(3), 427-35, 2014
  17. Value of a new stick-type rapid urine test for the diagnosis of Helicobacter pylori infection in the Vietnamese population, World J Gastroenterol , 20(17), 5087-5091, 2014
  18. High expression of gastrin receptor protein in injured mucosa of Helicobacter pylori-positive gastritis., Dig Dis Sci , 58(3), 634-40, 2013 Mar
  19. q uantitative identification of mucosal gastric cancer under magnifying endoscopy with flexible spectral imaging color enhancement., J Gastroenterol Hepatol , 28(5), 841-7, 2013 May
  20. Bile acid promotes intestinal metaplasia and gastric carcinogenesis., Cancer Epidemiol Biomarkers Prev , 21(11), 2101-7, 2012 Nov
  21. Changes in cardiovascular risk factors over a 24-year follow-up period: a Japanese pediatric cohort study., Hiroshima J Med Sci , 61(4), 85--9, 2012 Dec
  22. Clinical features of pharyngeal intraepithelial neoplasias and outcomes of treatment by endoscopic submucosal dissection., Gastrointest Endosc , 76(6), 1095-103, 2012 Dec
  23. Computer-aided system for predicting the histology of colorectal tumors by using narrow-band imaging magnifying colonoscopy (with video)., Gastrointest Endosc , 75(1), 179-85, 2012 Jan
  24. Microvascular structure and perfusion imaging of colon cancer by means of contrast-enhanced ultrasonography., Abdom Imaging , 37(2), 297-303, 2012 Apr
  25. Serum screening for detection of high-risk group for early-stage diffuse type gastric cancer in Japanese., J Gastroenterol Hepatol , 27(3), 598-602, 2012 Mar
  26. Change in malpractice claims in Japanese gastroenterological practice, Am J Gastroenterol, 107(1), 143-144, 20120101
  27. Advantages of endoscopic submucosal dissection versus endoscopic obliq ue aspiration mucosectomy for superficial esophageal tumors., J Gastroenterol Hepatol , 26(2), 275-80, 2011 Feb
  28. Freq uent somatic mutations of mitochondrial DNA in traditional serrated adenomas but not in sessile serrated adenomas of the colorectum., J Gastroenterol Hepatol , 26(10), 1566-9, 2011 Oct
  29. Genetic pathways of multiple esophageal sq uamous cell carcinomas., Oncol Rep , 25(2), 453-9, 2011 Feb
  30. Low prevalence of Helicobacter pylori-negative gastric cancer among Japanese., Helicobacter , 16(6), 415-9, 2011 Dec
  31. Plaunotol induces a comparative increase of acidic mucin fraction in gastric juice., Hepatogastroenterology , 58(106), 663-8, 2011 Mar
  32. Prevalence and impact of musculoskeletal pain in Japanese gastrointestinal endoscopists: a controlled study., World J Gastroenterol , 17(11), 1488-93, 2011 Mar
  33. q uantitative analysis of colorectal lesions observed on magnified endoscopy images., J Gastroenterol , 46(12), 1382-90, 2011 Dec
  34. A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas., Hiroshima J Med Sci , 59(1), 1-6, 2010 Mar
  35. Characteristics of esophageal sq uamous cell carcinomas and lugol-voiding lesions in patients with head and neck sq uamous cell carcinoma., J Clin Gastroenterol , 44(2), e27-33, 2010 Feb
  36. Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development., J Med Microbiol , 59(Pt 12), 1484-9, 2010 Dec
  37. Natural course of lugol-voiding lesions in patients with superficial esophageal sq uamous cell carcinoma., Digestion , 82(1), 60--5, 2010
  38. Outcome of endoscopic submucosal dissection for colorectal tumors accompanied by fibrosis., Scand J Gastroenterol , 45(11), 1329-37, 2010 Nov
  39. q uantitative analysis and development of a computer-aided system for identification of regular pit patterns of colorectal lesions., Gastrointest Endosc , 72(5), 1047-51, 2010 Nov
  40. Relationship between Helicobacter pylori tyrosine-phosphorylated CagA-related markers and the development of diffuse-type gastric cancers: a case-control study., Digestion , 82(1), 10--7, 2010
  41. Synchronous and subseq uent lesions of serrated adenomas and tubular adenomas of the colorectum., Pathobiology , 77(5), 273-7, 2010
  42. Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma., Cancer Sci , 100(6), 1075-81, 2009 Jun
  43. Cheilitis granulomatosa as an early manifestation of Crohn's disease., Clin J Gastroenterol , 23(3), 190-3, 2009 Jun
  44. Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract., J Gastroenterol Hepatol , 24(4), 537-46, 2009 Apr
  45. Evaluation and validation of computed virtual chromoendoscopy in early gastric cancer., Gastrointest Endosc , 69(6), 1052-8, 2009 May
  46. Little necessity of acid inhibition against proton pump inhibitor rebound effects and prior helicobacter pylori eradication therapy in gastric ulcer patients: a randomized prospective study., Hepatogastroenterology , 56(91-92), 624-8, 2009 May-
  47. Meta-analysis used to identify factors associated with the effectiveness of proton pump inhibitors against non-erosive reflux disease., J Gastroenterol Hepatol , 24(8), 1326-32, 2009 Aug
  48. Metachronous multiple esophageal sq uamous cell carcinomas and Lugol-voiding lesions after endoscopic mucosal resection., Endoscopy , 41(4), 304-9, 2009 Apr
  49. Pathogenetic role of the tyrosine-phosphorylated CagA EPIYA seq uence of Helicobacter pylori in histological gastritis in Japanese patients., J Gastroenterol , 44(5), 405-11, 200944(5
  50. Predicting the clinical response to cytapheresis in steroid-refractory or -dependent ulcerative colitis using contrast-enhanced ultrasonography., Scand J Gastroenterol , 44(7), 831-7, 200944(7
  51. Usefulness of endoscopic ultrasonography in determining the depth of invasion and indication for endoscopic treatment of early gastric cancer., J Clin Gastroenterol , 43(4), 318-22, 2009 Apr
  52. [A case report of anaphylactoid purpura with acute abdominal pain secondary to trauma caused by traffic accident]., Nihon Shokakibyo Gakkai Zasshi , 105(4), 566-71, 2008 Apr
  53. Clinical significance of type V(I) pit pattern subclassification in determining the depth of invasion of colorectal neoplasms., World J Gastroenterol , 14(2), 211-7, 2008 Jan
  54. Cost-effectiveness of gargling for the prevention of upper respiratory tract infections, BMC HEALTH SERVICES RESEARCH, 8, 2008
  55. Evaluation of gastric cancer risk using topography of histological gastritis: a large-scaled cross-sectional study., Dig Dis Sci , 53(7), 1818-23, 2008 Jul
  56. Genetic polymorphisms and head and neck cancer risk (Review)., Int J Oncol , 32(5), 945-73, 2008 May
  57. Optical biopsy of early gastroesophageal cancer by catheter-based reflectance-type laser-scanning confocal microscopy., J Biomed Opt , 13(5), 2008 Sep-
  58. Presence of poorly differentiated component correlated with submucosal invasion in the early diffuse-type gastric cancer., Hepatogastroenterology , 55(88), 2264-8, 2008 Nov-
  59. Primary follicular lymphoma of the gastrointestinal tract: a retrospective case series., Endoscopy , 40(4), 343-6, 2008 Apr
  60. Rapid progression of Epstein-Barr-virus-positive gastric diffuse large B-cell lymphoma during chemoradiotherapy: a case report., Clin J Gastroenterol , 1(3), 105-9, 2008 Oct
  61. Role of the gastrin-gastrin receptor system in the expansive growth of human gastric neoplasms., Digestion , 78(2-3), 163-70, 200878(2
  62. Strategy for treatment of nonerosive reflux disease in Asia., World J Gastroenterol , 14(20), 3123-8, 2008 May
  63. Cavernous hemangioma in the ascending colon treated by endoscopic mucosal resection., J Gastroenterol Hepatol , 22(2), 280-1, 2007 Feb
  64. Evaluation of microvessels in colorectal tumors by narrow band imaging magnification., Gastrointest Endosc , 66(5), 945-52, 2007 Nov
  65. Helicobacter pylori - Associated gastritis is related to babA2 expression without heterogeneity of the 3 ' region of the cagA genotype in gastric biopsy specimens, Pathobiology , 74(5), 309-316, 2007
  66. Helicobacter pylori-associated gastritis is related to babA2 expression without heterogeneity of the 3' region of the cagA genotype in gastric biopsy specimens., Pathobiology , 74(5), 309-16, 2007
  67. Host factors contributing to the discovery of gastric cancer after successful eradication therapy of Helicobacter pylori: preliminary report., J Gastroenterol Hepatol , 22(4), 571-6, 2007 Apr
  68. Immune response to CagA protein is associated with improved platelet count after Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura., Helicobacter , 12(1), 36--42, 2007 Feb
  69. Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma., World J Gastroenterol , 13(29), 3932-8, 2007 Aug
  70. Lymphatic vessel density at the site of deepest penetration as a predictor of lymph node metastasis in submucosal colorectal cancer., Dis Colon Rectum , 50(1), 13-21, 2007 Jan
  71. Magnifying endoscopy with narrow band imaging for diagnosis of colorectal tumors., Gastrointest Endosc , 65(7), 988-95, 2007 Jun
  72. Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia., J Gastroenterol Hepatol , 22(3), 304-10, 2007 Mar
  73. Optical biopsy of GI lesions by reflectance-type laser-scanning confocal microscopy., Gastrointest Endosc , 66(1), 144-9, 2007 Jul
  74. ★, Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: a case-control study., Scand J Gastroenterol , 42(6), 760-4, 2007 Jun
  75. Role of Helicobacter pylori infection and chronic inflammation in gastric cancer in the cardia., Jpn J Clin Oncol , 37(5), 365-9, 2007 May
  76. Serum pepsinogen levels in the Japanese population: prospective study of 9 years of follow-up., Hepatogastroenterology , 54(78), 1887-90, 2007 Sep
  77. Treatment of functional dyspepsia with serotonin agonists: a meta-analysis of randomized controlled trials., J Gastroenterol Hepatol , 22(10), 1566-70, 2007 Oct
  78. A case of Crohn's disease with hydronephrosis caused by ureteropelvic junction obstruction., Eur J Gastroenterol Hepatol , 18(9), 1015-8, 2006 Sep
  79. Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer., Gastrointest Endosc , 64(6), 877-883, 2006 Dec
  80. Aged garlic extract has potential suppressive effect on colorectal adenomas in humans, JOURNAL OF NUTRITION, 136(3), 821S-826S, 2006
  81. Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients., Oncol Rep , 16(1), 11-5, 2006 Jul
  82. Defensive medicine practices among gastroenterologists in Japan., World J Gastroenterol , 12(47), 7671-5, 2006 Dec
  83. Deletion of the KIT gene is associated with liver metastasis and poor prognosis in patients with gastrointestinal stromal tumor in the stomach., Int J Oncol , 28(6), 1361-7, 2006 Jun
  84. Development of a novel method to detect Helicobacter pylori cagA genotype from paraffin-embedded materials: comparison between patients with duodenal ulcer and gastric cancer in young Japanese., Digestion , 73(1), 47-53, 200673(1
  85. Endoscopic submucosal dissection for residual/local recurrence of early gastric cancer after endoscopic mucosal resection., Endoscopy , 38(10), 996-1000, 2006 Oct
  86. Genetic and pathologic characteristics of gastrointestinal stromal tumors in extragastric lesions., Int J Mol Med , 18(6), 1067-71, 2006 Dec
  87. Genetic progression and divergence in superficial esophageal sq uamous cell carcinoma by loss of heterozygosity analysis., Oncol Rep , 16(4), 685-91, 2006 Oct
  88. Helicobacter pylori infection is the major risk factor for gastric inflammation in the cardia., Dig Dis Sci , 51(9), 1582-8, 2006 Sep
  89. Medical malpractice litigation in gastroenterological practice in Japan: a 22-yr review of civil court cases., Am J Gastroenterol , 101(9), 1951-3, 2006 Sep
  90. Medical malpractice litigation related to gastrointestinal endoscopy in Japan: a two-decade review of civil court cases., World J Gastroenterol , 12(42), 6857-60, 2006 Nov
  91. Neuropilin-1 is involved in regulation of apoptosis and migration of human colon cancer., Int J Oncol , 29(1), 105-16, 2006 Jul
  92. Nuclear and mitochondrial DNA microsatellite instability in gastrointestinal stromal tumors., Pathobiology , 73(2), 93--7, 2006
  93. The effect of Helicobacter pylori eradication therapy on gastric ulcer healing after endoscopic mucosal resection., J Clin Gastroenterol , 40(4), 293-6, 2006 Apr
  94. A combination of the Helicobacter pylori stool antigen test and urea breath test is useful for clinical evaluation of eradication therapy: a multicenter study., J Gastroenterol Hepatol , 20(8), 1241-5, 2005 Aug
  95. Cardiac glands hyperplastic polyp of the stomach., J Gastroenterol Hepatol , 20(9), 1461-3, 2005 Sep
  96. Diagnostic ability of high-freq uency ultrasound probe sonography in staging early gastric cancer, especially for submucosal invasion., Abdom Imaging, 30(5), 518-23, 2005 Sep-
  97. Infliximab therapy for Crohn's disease in a patient with chronic hepatitis B., Dig Dis Sci , 50(1), 163-6, 2005 Jan
  98. Loss of heterozygosity on chromosome 10p14-p15 in colorectal carcinoma., Pathobiology , 72(4), 220-4, 2005
  99. Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment., Clin Cancer Res , 11(21), 7629-36, 2005 Nov
  100. Morphological changes in human gastric tumours after eradication therapy of Helicobacter pylori in a short-term follow-up., Aliment Pharmacol Ther , 21(5), 559-66, 2005 Mar
  101. Somatic mutations of mitochondrial DNA in digestive tract cancers., J Gastroenterol Hepatol , 20(11), 1679-84, 2005 Nov
  102. Angiogenic switch occurs during the precancerous stage of human esophageal sq uamous cell carcinoma., Oncol Rep , 11(2), 315-9, 2004 Feb
  103. Characteristics and trends of clarithromycin-resistant Helicobacter pylori isolates in Japan over a decade., Pathobiology , 71(3), 159-63, 2004
  104. Chromosomal and microsatellite instability in sporadic gastric cancer., J Gastroenterol Hepatol , 19(7), 756-60, 2004 Jul
  105. Clinicopathologic and endoscopic features of colorectal serrated adenoma: differences between polypoid and superficial types., Gastrointest Endosc , 59(2), 213-219, 2004 Feb
  106. Effects of aged garlic extract (AGE) on colorectal adenomas: a double-blinded study., Hiroshima J Med Sci , 53(3-4), 39--45, 2004 Dec
  107. Expression of human telomerase reverse transcriptase mRNA in esophageal cancers and precancerous lesions., Oncol Rep , 11(1), 51--5, 2004 Jan
  108. Freq uent loss of heterozygosity on chromosome 10p14-p15 in esophageal dysplasia and sq uamous cell carcinoma., Oncol Rep , 12(2), 333-7, 2004 Aug
  109. Magnifying colonoscopic features of ulcerative colitis reflect histologic inflammation., Inflamm Bowel Dis , 10(6), 737-44, 2004 Nov
  110. Magnifying gastroendoscopy for diagnosis of histologic gastritis in the gastric antrum., Dig Liver Dis , 36(4), 286-91, 2004 Apr
  111. Mucin phenotype and background mucosa of intramucosal differentiated-type adenocarcinoma of the stomach., Oncology , 66(5), 379-87, 2004
  112. Clinical significance of angiogenic factor expression at the deepest invasive site of advanced colorectal carcinoma., Oncology , 64(1), 61-73, 2003
  113. Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types., Int J Mol Med , 12(4), 437-42, 2003 Oct
  114. Clinicopathologic features and endoscopic resection of early primary nonampullary duodenal carcinoma., J Clin Gastroenterol , 37(5), 381-6, 2003 Nov-
  115. Expression of vascular endothelial growth factor and angiogenesis in gastrointestinal stromal tumor of the stomach., Oncology , 64(3), 266-74, 2003
  116. Food deprivation enhances somatostatin and somatostatin receptor subtype expression in rat colon., Regul Pept , 114(2-3), 167-73, 2003 Jul
  117. Freq uent loss of heterozygosity on chromosome 10p15, a putative telomerase repressor/senescence gene locus, in gastric cancer., Oncol Rep , 10(5), 1297-9, 2003 Sep-
  118. Gastric juice nitrite and vitamin C in patients with gastric cancer and atrophic gastritis: is low acidity solely responsible for cancer risk?, Eur J Gastroenterol Hepatol , 15(9), 987-93, 2003 Sep
  119. Helicobacter pylori infection influences tumor growth of human gastric carcinomas., Scand J Gastroenterol , 38(2), 153-8, 2003 Feb
  120. Isolated granulomatous gastritis successfully treated by Helicobacter pylori eradication: a possible association between granulomatous gastritis and Helicobacter pylori., J Gastroenterol , 38(4), 371-5, 2003
  121. Long-term observation of reflux oesophagitis developing after Helicobacter pylori eradication therapy., Aliment Pharmacol Ther , 17(12), 1529-34, 2003 Jun
  122. Minute depressed colon cancer with submucosal invasion., Gastrointest Endosc , 57(4), 564-5, 2003 Apr
  123. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas., Int J Oncol , 22(4), 773-8, 2003 Apr
  124. Necessity of multiple gastric biopsies from different sites for detection of clarithromycin-resistant Helicobacter pylori strains., Scand J Gastroenterol , 38(9), 942-6, 2003 Sep
  125. Nodular gastritis in adults is caused by Helicobacter pylori infection., Dig Dis Sci, 48(5), 968-75, 2003 May
  126. p53 expression, K-ras gene mutation and microsatellite instability in gastric B-cell lymphomas., J Gastroenterol Hepatol , 18(9), 1047-53, 2003 Sep
  127. Prevalence of Helicobacter pylori resistance to clarithromycin and metronidazole determined by 23S ribosomal RNA and rdxA gene analyses in Hiroshima, Japan., J Gastroenterol Hepatol , 18(10), 1202-7, 2003 Oct
  128. Serum pepsinogen concentration as a marker of Helicobacter pyloriinfection and the histologic grade of gastritis; evaluation of gastric mucosa by serum pepsinogen levels., J Gastroenterol , 38(4), 332-8, 2003
  129. Small rectal carcinoid with lymph node metastasis diagnosed prior to treatment., Eur J Gastroenterol Hepatol , 15(2), 195-7, 2003 Feb
  130. Somatic mutation in mitochondrial DNA and nuclear microsatellite instability in gastric cancer., Oncol Rep , 10(6), 1837-41, 2003 Nov-
  131. Somatic mutation of mitochondrial DNA in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer., Int J Mol Med , 12(2), 169-74, 2003 Aug
  132. The long-term effect of Helicobacter pylori eradication therapy on symptoms in dyspeptic patients with fundic atrophic gastritis, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 18(2), 245-252, 2003
  133. The specific expression of hypoxia inducible factor-1alpha in human gastric mucosa induced by nonsteroidal anti-inflammatory drugs., Aliment Pharmacol Ther , 18 (Suppl 1), 90-8, 2003 Jul
  134. [Non-ulcer dyspepsia and H. pylori]., Nihon Rinsho , 60 (Suppl 2), 774-8, 2002 Feb
  135. [The analysis of the recurrence ulcer after H. pylori eradication]., Nihon Rinsho , 60 (Suppl 2), 501-5, 2002 Feb
  136. Advanced colorectal carcinoma smaller than 10 mm in maximum diameter with special reference to clinicopathologic and molecular features: a report of 3 cases, Gastrointest Endosc , 56(2), 299-303, 2002
  137. Cigarette smoking promotes atrophic gastritis in Helicobacter pylori-positive subjects., Dig Dis Sci , 47(3), 675-81, 2002 Mar
  138. Clinical characteristics and natural history of patients with low-grade reflux esophagitis., J Gastroenterol Hepatol , 17(9), 949-54, 2002 Sep
  139. Clinical significance of angiogenesis in rectal carcinoid tumors., Oncol Rep , 9(3), 489-494, 2002 May-
  140. Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma., Oncology , 62(2), 157-66, 2002
  141. Determining depth of invasion by VN pit pattern analysis in submucosal colorectal carcinoma., Oncol Rep , 9(5), 1005-8, 2002 Sep-
  142. Five cases of nodular gastritis and gastric cancer: a possible association between nodular gastritis and gastric cancer, Dig Liver Dis, 34(11), 819-820, 20020401
  143. Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis., Aliment Pharmacol Ther , 16(8), 1449-56, 2002 Aug
  144. Helicobacter pylori infection increases serum nitrate and nitrite more prominently than serum pepsinogens., Helicobacter , 7(1), 9-13, 2002 Feb
  145. Human telomerase reverse transcriptase, p53 and Ki-67 expression and apoptosis in colorectal serrated adenoma., Scand J Gastroenterol , 37(10), 1194-200, 2002 Oct
  146. Implication of anti-parietal cell antibody levels in gastrointestinal diseases, including gastric carcinogenesis., Dig Dis Sci , 47(5), 1080-5, 2002 May
  147. K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer., Int J Cancer , 97(5), 562-6, 2002 Feb
  148. Long-term rebamipide therapy improves Helicobacter pylori-associated chronic gastritis, DIGESTIVE DISEASES AND SCIENCES, 47(4), 862-867, 2002
  149. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal sq uamous cell carcinomas., Int J Cancer , 102(3), 220-4, 2002 Nov
  150. p53 Codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis., Int J Cancer , 100(3), 304-8, 2002 Jul
  151. Reflux esophagitis:natural history and treatment Clinical characteristics and natural history of patients with low-grade reflux esophagitis, J Gastroen Hepatol, 17, 949-954, 20020401
  152. Role of anti-parietal cell antibody in Helicobacter pylori-associated atrophic gastritis: evaluation in a country of high prevalence of atrophic gastritis., Scand J Gastroenterol , 37(3), 287-93, 2002 Mar
  153. Role of Anti-Parietal Cell Antibody in Helicobacter pylori-associated Atrophic Gastritis:Evaluation in a Country of High Prevalence of Atrophic Gastriris, Scand J Gastroentero, 3, 287-293, 20020401
  154. Serological comparison of serum pepsinogen and anti-parietal cell antibody levels between Japanese and German patients., Eur J Gastroenterol Hepatol , 14(2), 123-7, 2002 Feb
  155. Single administration of ecabet sodium diminishes the level of delta-(13) Co(2) in urea breath test, J GastroenterolM, 37(8), 674-675, 20020401
  156. Vascular endothelial growth factor-C expression predicts lymph node metastasis of human gastric carcinomas invading the submucosa., Eur J Cancer , 38(10), 1413-9, 2002 Jul
  157. A low 13C-urea breath test value is associated with increased risk of gastric cancer., J Gastroenterol , 36(9), 601-5, 2001 Sep
  158. Angiogenesis at the site of deepest penetration predicts lymph node metastasis of submucosal colorectal cancer., Dis Colon Rectum , 44(8), 1129-36, 2001 Aug
  159. B-cell monoclonality in Helicobacter pylori-associated chronic atrophic gastritis., Virchows Arch , 438(3), 232-7, 2001 Mar
  160. Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer., Eur J Cancer , 37(2), 180-8, 2001 Jan
  161. Clinical significance of human erythrocyte glucose transporter 1 expression at the deepest invasive site of advanced colorectal carcinoma., Oncology , 60(2), 162-9, 2001
  162. Clinicopathologic features and endoscopic treatment of superficially spreading colorectal neoplasms larger than 20 mm., Gastrointest Endosc , 54(1), 62-67, 2001 Jul
  163. Clinicopathological features of gastric mucosa-associated lymphoid tissue lymphoma: a comparison with diffuse large B-cell lymphoma without a mucosa-associated lymphoid tissue lymphoma component., J Gastroenterol Hepatol , 16(7), 734-739, 2001 Jul
  164. Clinicopathological significance of vascular endothelial growth factor (VEGF)-C in human esophageal sq uamous cell carcinomas., Int J Cancer , 93(5), 662-6, 2001 Sep
  165. c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma., Oncol Rep , 8(2), 289-92, 2001 Mar-
  166. Duodenogastric reflux is associated with antral metaplastic gastritis., Gastrointest Endosc , 53(1), 53--9, 2001 Jan
  167. Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability., Int J Oncol , 18(6), 1207-12, 2001 Jun
  168. Interleukin 8 and vascular endothelial growth factor -- prognostic factors in human gastric carcinomas?, Eur J Cancer , 37(12), 1482-7, 2001 Aug
  169. Microsatellite instability at D18S61 is associated with no regression of gastric mucosa-associated lymphoid tissue lymphoma after Helicobacter pylori eradication., Oncol Rep , 8(2), 293-7, 2001 Mar-
  170. Microsatellite instability is a genetic marker for the development of multiple gastric cancers., Int J Cancer , 95(6), 350-3, 2001 Nov
  171. MUC1 and cathepsin D expression in early colorectal carcinoma showing V type pit pattern., Int J Oncol , 19(4), 665-72, 2001 Oct
  172. Reduction in the incidence of Helicobacter pylori-associated carcinoma in Japanese young adults., Oncol Rep , 8(3), 633-6, 2001 May-
  173. Acid-sensitive and alkaline-sensitive sensory neurons regulate pH dependent gastrin secretion in rat., Dig Dis Sci , 45(6), 1217-26, 2000 Jun
  174. Cetraxate, a mucosal protective agent, combined with omeprazole, amoxycillin, and clarithromycin increases the eradication rate of helicobacter pylori in smokers., Aliment Pharmacol Ther , 14(8), 1089-94, 2000 Aug
  175. Conditions of curability after endoscopic resection for colorectal carcinoma with submucosally massive invasion., Oncol Rep , 7(4), 783-8, 2000 Jul-
  176. Effect of age and Helicobacter pylori infection on gastric acid secretion., J Gastroenterol Hepatol , 15(3), 277-83, 2000 Mar
  177. Electrocautery snare resection stimulates cellular proliferation of residual colorectal tumor: an increasing gene expression related to tumor growth., Dis Colon Rectum , 43(8), 1107-15, 2000 Aug
  178. Enhanced tumorigenicity of insulinoma by X-irradiation of the gastric regions in Sprague-Dawley male rats., J Gastroenterol Hepatol , 15(7), 766-70, 2000 Jul
  179. Eradication therapy of Helicobacter pylori for low-grade mucosa-associated lymphoid tissue lymphomas of the stomach, EXPERIMENTAL ONCOLOGY, 22(1-2), 78-81, 2000
  180. Factors that affect results of the C-13 urea breath test in Japanese patients, Helicobacter , 5(2), 98-103, 2000
  181. Growth characteristics of rectal carcinoid tumors., Oncology , 59(3), 229-37, 2000 Sep
  182. Helicobacter pylori infection is a major risk factor for gastric carcinoma in young patients., Scand J Gastroenterol , 35(3), 255-9, 2000 Mar
  183. High incidence of reflux oesophagitis after eradication therapy for Helicobacter pylori: impacts of hiatal hernia and corpus gastritis., Aliment Pharmacol Ther , 14(6), 729-35, 2000 Jun
  184. Negative association between Helicobacter pylori infection and reflux esophagitis in older patients: case-control study in Japan., Helicobacter , 5(1), 24--9, 2000 Mar
  185. Pit pattern diagnosis of early colorectal carcinoma by magnifying colonoscopy: clinical and histological implications., Int J Oncol , 16(5), 927-34, 2000 May
  186. Predictive value of cathepsin D and Ki-67 expression at the deepest penetration site for lymph node metastases in gastric cancer., Oncol Rep , 7(4), 713-8, 2000 Jul-
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