YUMIKO SAITO

Last Updated :2018/06/14

Affiliations, Positions
Graduate School of Integrated Arts and Sciences, ., Professor
E-mail
yumisthiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2001/04/01, 2006/09/30, Saitama Medical School, Department of Pharmacology, Lecturer
  • 2000/07/01, 2001/03/31, Tokyo Metropolitan Institute of Medical Science, ., Researcher
  • 1997/07/01, 2000/06/30, University of California, Ivine, Associate Specialist
  • 1992/04/01, 1997/06/30, Tokyo Metropolitan Institute of Medical Science, ., Researcher
  • 1987/06/01, 1992/03/31, Tokyo Metropolitan Institute of Gerontology, ., Project Researcher

Educational Backgrounds

  • Ochanomizu University, Graduate School, Division of Natural Science, Japan, 1981/04, 1983/03

Academic Degrees

  • Doctor of Science, The University of Tokyo
  • Master of Science, Ochanomizu University

Research Fields

  • Biological Sciences;Neuroscience;Neurochemistry / Neuropharmacology

Research Keywords

  • feeding
  • RGS protein
  • G protein
  • GPCR-mediated signaling
  • depression and anxiety
  • primary cilia
  • orphan GPCR

Educational Activity

Course in Charge

  1. 2018, Liberal Arts Education Program1, 3Term, Brain and Behavior
  2. 2018, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  3. 2018, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  4. 2018, Liberal Arts Education Program1, First Semester, Biology
  5. 2018, Undergraduate Education, 1Term, Brain Science
  6. 2018, Graduate Education (Master's Program) , First Semester, Seminar in Integrated Arts and Sciences
  7. 2018, Undergraduate Education, 2Term, Introduction to Life Sciences
  8. 2018, Undergraduate Education, 1Term, Fundamental Cell Biology
  9. 2018, Undergraduate Education, 2Term, Cell Biology
  10. 2018, Undergraduate Education, 2Term, Laboratory Work in Life Sciences D
  11. 2018, Undergraduate Education, 2Term, Practical Methods in Life Sciences D
  12. 2018, Undergraduate Education, First Semester, Fundamental Laboratory Work in Biology
  13. 2018, Undergraduate Education, First Semester, Fundamental Methodology in Biology
  14. 2018, Graduate Education (Master's Program) , Second Semester, Seminar in Integrated Arts and Sciences
  15. 2018, Graduate Education (Master's Program) , 3Term, Advanced Molecular and Cellular Neurobiology

Research Activities

Academic Papers

  1. Depression-resistant phenotype in mice overexpressing regulator of G protein signaling-8 (RGS8), Neuroscience, 383, 160-169, 20180517
  2. Cytoskeleton-related regulation of primary cilia shortening mediated by melanin-concentrating hormone receptor 1, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 253, 44-52, 20170821
  3. Dimerization of melanocortin receptor 1 (MC1R) and MC5R creates a ligand-dependent signal modulation: Potential participation in physiological color change in the flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 230, 103-109, 20160501
  4. Modulation of primary cilia length by melanin-concentrating hormone receptor 1, Cellular Signalling, 28, 572-584, 20160601
  5. Molecular Mechanisms of Melanin-Concentrating Hormone Receptor 1 Internalization, 51(1), 13-16, 20160401
  6. Melanin-concentrating hormone-Current advances, Journal of clinical and experimental medicine, 256(5), 608-6015, 20160130
  7. Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1, Cellular Signalling, 27(4), 818-827, 20150401
  8. Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 212, 114-123, 20150401
  9. Involvement of melanin-concentrating hormone 2 in background color adaptation of barfin flounder Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 214, 140-148, 20150401
  10. Interrelation between melanocyte-stimulating hormone and melanin-concentrating hormone in physiological body color change: Roles emerging from barfin flounder Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 181, 229-234, JAN 15 2013
  11. Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 188, 159-165, JUL 1 2013
  12. Regulated control of melanin-concentrating hormone receptor 1 through glycosylation and phosphorylation., Frontiers in Endocrinology, 4, e154, 20131001
  13. Mutation of Phe318 within the NPxxY(x)5,6F motif in melanin-concentrating hormone receptor 1 results in an efficient signaling activity., Front. Endocrinology, 20121101
  14. Inhibiting roles of melanin-concentrating hormone for skin pigment dispersion in barfin flounder, Verasper moseri (vol 171, pg 75, 2011), GENERAL AND COMPARATIVE ENDOCRINOLOGY, 179(3), 358-358, 2012
  15. Melanocortin systems on pigment dispersion in fish chromatophores., Frontiers in Experimental Endocrinology, 20120201
  16. Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2, REGULATORY PEPTIDES, 169(1-3), 6-12, AUG 8 2011
  17. Signalling pathway of the goldfish melanin-concentrating hormone receptor 1 and 2, Regulatory Peptides, 169, 6-12, 20110601
  18. Melanin: concentrating hormone, 62(1), 37-43, 201101
  19. Identification, Localization, and Function of a Novel Avian Hypothalamic Neuropeptide, 26RFa, and Its Cognate Receptor, G Protein-Coupled Receptor-103, ENDOCRINOLOGY, 151(5), 2255-2264, MAY 2010
  20. Functional interaction of regulator of G-protein-signaling-2 with melanin-concentrating hormone receptor 1, Ann NY Science, 1200, 112-119, 20100401
  21. Identification of amino acid involved in "gain-of-function" conformational dynamics of melanin-concentrating hormone receptor, NEUROSCIENCE RESEARCH, 68, E224-E224, 2010
  22. The anorexic effect of the MCH1 receptor antagonist, TPI1361-17, ENDOCRINE JOURNAL, 57, S435-S435, 2010
  23. Identification, Localization, and Function of a Novel Avian Hypothalamic Neuropeptide, 26RFa, and Its Cognate Receptor, G Protein-Coupled Receptor-103, ENDOCRINOLOGY, 151(5), 2255-2264, 2010
  24. Regulation of somatolactin release from cultured goldfish pituitary cells by PACAP and MCH, JOURNAL OF MOLECULAR NEUROSCIENCE, 42(3), 308-308, 2010
  25. Melanin-concentrating hormone, Japanese journal of clinical medicine, 68(0), 125-128, 201002
  26. Melanin-concentrating hormone reduces somatolactin release from cultured goldfish pituitary cells, JOURNAL OF ENDOCRINOLOGY, 203(3), 389-398, 2009
  27. T(H)2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 124(3), 612-U328, 2009
  28. Regulation of melanin-concentrating hormone receptor 1 signaling by RGS8 with the receptor third intracellular loop. ,, Cellular Signaling, 20, 2084-2094, 20080719
  29. 2S5-4 Regulation of the melanin-concentrating hormone receptor signaling(2S5 Physical studies on the biological functions of G-protein coupled receptors,The 46th Annual Meeting of the Biophysical Society of Japan), Biophysics, 48(1), 20081025
  30. Evolution of the Xenopus piggyBac transposon family TxpB: Domesticated and untamed strategies of transposon subfamilies, MOLECULAR BIOLOGY AND EVOLUTION, 24(12), 2648-2656, DEC 2007
  31. The role of MCH-MCH receptor system in feeding and depression, Folia Pharmacologica Japonica, 130(1), 34-38, 20070701
  32. Lignan compounds and 4,4'-dihydroxybiphenyl protect C2C12 cells against damage from oxidative stress, Biophys Biochem Res Commun, 344, 394-396, 20061001
  33. Kyotorphin has a novel role on rat cardiac muscle, Biophys Biochem Res Commun, 339, 805-809, 20060601
  34. Identification of MCH receptor and its impact on drug discovery, Journal of Experimental Zoology, 305, 761-768, 20061201
  35. Finding a novel target for depression through the orphan receptor strategy, Folia Pharmacologica Japonica, 127(3), 190-195, 20060301
  36. Physiological role of melanin-concentrating hormone and its receptor, Clinical Neuroscience, 24, 968-969, 20060701
  37. Orphan GPCR, Pharmacology and Therapeutics, 110, 525-532, 20061001
  38. Salusin beta is a surrogate lignad of the mas-like G-protein-coupled receptor MrgA1, European J Pharmacologu, 145-150, 20060901
  39. Arginine residue 155 in the second intracellular loop plays a critical role in rat melanin-concentrating hormone receptor 1, Endocrinology, 146, 3452-3462, 20050801
  40. The basic residues in the membrane proximal C-terminal tail of the melanin-concentrating hormone receptor 1 is required for receptor function., Endocrinology, 145, 3712-3723, 20040801
  41. Properties of the rat melanin concentrating hormone receptor 1 internalization., Peptides, 25, 1597-1604, 20041101
  42. Role of asparagine-linked oligosaccharides in the function of the melanin-concentrating hormone (MCH) receptor 1., FEBS Letter, 533, 29-34, 20030701
  43. Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain., J. Comp. Neurology, 435, 26, 20011001
  44. Endogenous melanin-concentrating hormone receptor SLC-1 in human melanoma SK-MEL-37 cells, BBRC, 289, 44-50, 20010601
  45. Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors. . 24, 230-237., Trends in Neurosci, 24, 230, 20010801
  46. Searching for neurotransmitters as cognate ligands of orphan G protein-coupled receptor : Finding receptor for melaninconcentrating hormone, 21(3), 77-82, 20010925
  47. Melanin-concentrating hormone receptor : An orphan receptor fits the key., Trends in Endocrinology and Metabolism, 11, 299, 20001201
  48. Identification of the natural ligand of an orphan G protein-coupled receptor involved in the regulation of vasoconstriction., Nature Cell Biology, 1, 383, 19991101
  49. Molecular characterization of the melanin-concentrating-hormone receptor., Nature, 400, 265, 19990715
  50. Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells., J. Neurosci.Res, 48, 397-406, 1997
  51. Molecular cloning and characterization of a novel form of neuropeptide gene as a developmentally regulated molecule., J. Biol. Chem., 271, 15615, 19961201
  52. Differential Inhibition of Calpain and Proteasone Activities by Peptidyl Aldehydes of Di-Leucine and Tri-Leucine, J Biochem (Tokyo), 119(3), 572-576, 19960301
  53. Identification and characterization of membrane-bound calpains in clathrin-coated vesicles from bovine brain., Eur. J. Biochem., 230, 25-31, 1995
  54. N23K, a gene transiently up-regulated during neural differentiaton, encodes a precursor protein for a new identified neuropeptide nociceptin., Biochem. Biophys. Res. Commun., 217, 539-545, 1995
  55. The calpain-calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cells., FEBS Lett., 353, 327-331, 1994
  56. Inhibition of DNA polymerase by tripeptide derivative protease inhibitors., Biochem. Biophys. Res. Commun, 185, 1133-1140, 1992
  57. Possible Involvement of Clathrin in Neuritogenesis Induced by a Protease Inhibitor(Benzyloxycarbonyl-Leu-Leu-Leu-Aldehyde) in PC12 Cells., J Biochem (Tokyo), 112(4), 448-455, 1992
  58. Isolation and characterization of possible target proteins responsible for neurite outgrowth induced by tripeptide aldehyde in PC12 cells., Biochem. Biophys. Res. Commun., 184, 419-426, 1992
  59. Replacement of m-calpain by u-calpain during maturation of megakaryocytes and possible involvement in platelet formation., Thrombos. Res., 66, 757-764, 1992
  60. Calpain activation is essential for membrane fusion of erythrocytes in the presence of calcium., Biochem. Biophys. Res. Commun., 182, 939-946, 1992
  61. The Synthesis and Properties of Tripeptide Aldehydes Having Neurite-Extension Activity, Journal of the Chemical Society of Japan,chemistry and industrial chemistry, 1992(11), 1363-1367, 19921110
  62. Activation of intracellular calcium-activated neutral protease in erythrocytes and its inhibition by exogenously added inhibitors., Biochim. Biophys. Acta., 1094, 256-259, 1991
  63. Possible involvement of a novel protease in neurite outgrowth of PC12 cells, Neurosci. Res., 13, S97-S101, 1990
  64. Binding sites for calcium-activated neutral protease on erythrocyte membrane are not membrane phospholipids., Biochem. Biophys. Res. Commun., 171, 625-632, 1990
  65. The structure-function relationship between peptide aldehyde derivatives on initiation of neurite outgrowth in PC12 cells., Neurosci. Lett., 120, 1-4, 1990
  66. 神経突起伸長におけるプロテアーゼインヒビターの役割, 神経研究の進歩, 34, 632-641, 1990
  67. Properties of membrane binding and autolytic activation of calcium-activated neutral protease., J. Biol. Chem., 264, 18838-18843, 1989
  68. 神経分化におけるプロテアーゼ-プロテアーゼインヒビター系の関与, 11, 625-632, 1989
  69. The neurite-initiating effect of a tripeptide aldehyde protease inhibitor on PC12h cells., J Biochem (Tokyo), 106(6), 1035-1040, 1989
  70. Enhancement of neurite outgrowth in PC12h cells by a protease inhibitor, Neuroscience letters, 89, 102-107, 1988
  71. Tissue distribution of calcium-activated neutral protease in rat., Biochim.Biophys.Acta., 965, 130-135, 1988
  72. Rat atrial natriuretic polypeptide stimulation of adrenal zona glomerulosa cell growth, Biochem. Biophys. Res. Commun, 132(1), 261-263, 19851015

Publications such as books

  1. 2016, Encyclopedia of Signaling Molecules, 2nd Edition, Melanin-concentrating hormone receptor 1, Springer, 2016, English, Hamamoto A, Kobayashi Y, Saito Y.
  2. 2015/07/16, IUPHAR Database: Melanin-concentrating hormone receptor 1 and 2, 2015/07, 07, English, Valérie Audinot, Jean A. Boutin, Bernard Lakaye, Jean-Louis Nahon, Yumito Saito
  3. 2015/10/14, Handbook of Hormones. Comparative Endocrinology for Basic and Clinical Research, Melanin-concentrating hormone (MCH), Elsevier Science & Technology, 2015, 10, English, Hiroshi Nagasaki, Yumiko Saito, 978-0-12-801028-0, 674
  4. 2015/10/14, Handbook of Hormones. Comparative Endocrinology for Basic and Clinical Research, Cocaine and Amphetamine Regulated Transcript (CART), Elsevier Science & Technology, 2015, 10, English, Nagasaki H, Kobayashi Y, Saito Y, 978-0-12-801028-0, 674, 4
  5. 2008/01, New frontiers in lifestyle-related diseases , Orphan neuropetides and the regulation of food intake, 2008, 01, 9784431764, 160
  6. 2008/10, Results and Problems in Cell Differentiation-Orphan G protein-coupled receptors and novel neuropeptides, The Melanin-Concentrating Hormone System and Its Physiological Functions, 2008, 10, Nagasaki H, Saito Y, 21
  7. 2008/03, Delving into the Source of Knowledge (Liberal Arts in the 21st Century) , 2008, 03, 9784563019044, 260
  8. 2005, G-protein Coupled Receptors in Drug Discovery, Orphan G protein-coupled receptors: Promising Targets for Drug Discovery., Taylor & Francis Books, FL, USA., 2005, 19

Invited Lecture, Oral Presentation, Poster Presentation

  1. Presidential lecture: Searching a novel neurotransmitter/hormone through G-protein coupled receptor Where now and where next ?, Yumiko Saito, 2015/09/13, With Invitation, The Japanese Society for Neurochemistry, Omiya
  2. Structure -function insight on the melanin-concentrating hormone receptor 1, Yumiko Saito, 2015/03/23, With Invitation
  3. Signaling specificity on the melanin-concentrating hormone receptor 1, Yumiko Saito, 2015/03/20, With Invitation
  4. Identification of MCH receptor and its impact on drug discovery, Yumiko Saito, The 15th International coference of comparative endocrinology, 2005/52, With Invitation, Boston, USA
  5. The structure-function relationship of rat MCH receptor 1, Yumiko Saito, 2003/03, With Invitation, National Institute of Genetics
  6. MCH is the cognate ligand for the orphan GPCR: Feeding hormone finds its partner., Yumiko Saito, 2000/40, With Invitation, Dept. Medicine, Southern Illinois University
  7. Melanin-concentrating hormone is a cognate ligand for the orphan GPCR, Yumiko Saito, Riken, Wako, 2000/07, With Invitation
  8. Identification of MCH receptor, Yumiko Saito, UCI Neuroscience meeting, 1999/10/14, With Invitation, University of California, Irvine, Irvine, USA
  9. The growth promoting effect of orphaninFQ/nociceptin gene, Yumiko Saito, Seiichi Kawashima, The 28th International Narcotic Meeting, 1997/08/03, With Invitation, International Narcotic Society, Hong Kong
  10. Initiation of neurite outgrowth by tripeptide aldehyde derivatives., Seiichi Kawashima, Yumiko Saito, 1990/01, With Invitation
  11. Feeding-related neuropeptide receptor MCHR1 localizes to neuronal primary cilia on hippocampal slice culture, Daisuke Miki Tomoya Okada Yumiko Saito Yuki Kobayashi, Consortium of Biological Sciences 2017, 2017/12, Without Invitation
  12. Two distinct signaling pathways regulate cilia length shortening via ciliary melanin-concentrating hormone receptor 1, Kosuke Imakado Sakura Tomoshige Yuki Kobayashi Yumiko Saito, Consortium of Biological Sciences 2017, 2017/12, Without Invitation
  13. What is neuronal cilia ?, Yumiko Saito, 2017/09/10, With Invitation
  14. Immunoanalysis of melanin-concentrating hormone receptor 1 located in neuronal primary cilia, Tomoya Okada Shogo Yamato Daisuke Miki Yuki Kobayashi Yumiko Saito, JSN2017, 2017/09/08, Without Invitation, Sendai
  15. Shortening of primary cilia length by melanin-concentrating hormone receptor 1-Gi/o mediated signaling., Yumiko Saito, Akie Hamamoto, Sakura Tomoshige, Shogo Yamato, Kosuke Hosoba, Tatsuo Miyamoto, Yuki Kobayashi, The 28th CDB meeting: Cilia and centrosome, 2016/11/28, Without Invitation, Riken, Kobe
  16. Melanin-concentrating hormone-mediated signaling induces cilium shortening via Gi/o-dependent Akt phosphorylation., Saito Y, Hamamoto A, Yamoto S, Kobayashi Y., Society for Neuroscience, 2016/11/12, Without Invitation
  17. Metabolic GPCR-mediated primary cilia shortening through dynamic cytoskeletal reorganization, Sakura Tomoshige Kousuke Hosoba Akie Hamamoto Shogo Yamato Tatsuo Miyamoto Yuki Kobayashi Yumiko Saito, 2017JSN, 2017/09/08, Without Invitation
  18. Detection of ciliary GPCR in rodent central nervous system, 2016/05/14, Without Invitation
  19. Shortening of primary ciliary length by melanin-concentrating hormone receptor 1., 2016/05/14, Without Invitation
  20. Regulation of cilium length via melanin-concentrating hormone receptor 1, 2015/12/03, Without Invitation
  21. The intracellular residues which are important for the selective activation of Gi/o proteins in rat melanin-concentrating hormone receptor 1, Hamamoto A, Kobayashi Y, Saito Y., 6th Special Conference of International Society for Neurochemistry, 2014/09/21, Without Invitation
  22. A screening of new agonist for BRS-3 from a marine metagenome library, 2014/09, Without Invitation
  23. Regulaton of depression-related receptor signaling by Regulator of G protein signaling-8(RGS8), 2014/09, Without Invitation
  24. The intracellular residues which are important for the selective activation of Gi/o proteins in rat melanin-concentrating hormone, 2014/09, Without Invitation
  25. Identification of discrete amino acids that responsible for Gi/o selectivity by melanin-concentrating hormone receptor 1.Society for Neuroscience, A. Hamamoto、Y. Kobayashi、M. Horikawa、Y. Saito, Society for Neurosciecne, 2013/11, Without Invitation
  26. A. Hamamoto、Y. Kobayashi、Y. Saito.The structure-activity relationship in rat melanin-concentrating hormone receptor 1 -Structural determinants for G-protein selectivity., A. Hamamoto、Y. Kobayashi、Y. Saito., Neuro2013, 2013/06, Without Invitation
  27. The “gain-of-function” phenotype of rat melanin-concentrating hormone receptor., A. Hamamoto、M. Horikawa、Y. Saito., Congress Secretariat for The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry The 55th Annual Meeting of the Japanese Society for Neurochemistry, 2012/09/30, Without Invitation
  28. Identification of the determinant sites of Gi/o coupling by rat melanin-concentrating hormone receptor 1., 2011/09/27, Without Invitation
  29. Identification of ciliary targeting sequence of MCHR1 to primary cilia, 2011/09/26, Without Invitation
  30. Regulation of tachykinin receptor 1 signaling by regulator of G protein signaling-8 (RSG8), 2011/09/26, Without Invitation

Awards

  1. 2011年09月30日, special commendation award for grants in aid for scientific research in 2011, 独立行政法人日本学術振興会理事長 小野 元之

Social Activities

History as Committee Members

  1. Science Council of Japan, 2017/10, 2023/09, Science Council of Japan
  2. local organizing committee, 2014/09, 6th Special Conference of International Society for Neurochemistry