YUMIHOSHINO

Last Updated :2019/08/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, ., Assistant Professor
E-mail
hoshimihiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Graduate School of Integrated Science for Life, Assistant Professor
  • 2015/11/01, 2019/03/31, Hiroshima University, Graduate School of Biosphere Science, Assistant Professor
  • 2011/10/01, 2012/09/30, Stanford University, School of Medicine, Visiting Assistant Professor
  • 2007/12/01, 2015/10/31, Tohoku University, Graduate School of Agricultural Science, Assistant Professor
  • 2007/04/01, 2007/11/30, Tohoku University, Graduate School of Agricultural Science, Postdoctoral Fellow
  • 2005/04/01, 2007/03/31, Tohoku University, Graduate School of Agricultural Science, JSPS Research Fellowship for Young Scientists

Educational Backgrounds

  • Tohoku University, Graduate School of Agricultural Science, Division of Life Sciences, Japan, 2003/04, 2006/03
  • Tohoku University, Graduate School of Agricultural Science, Division of Biological Resource Sciences, Japan, 2001/04, 2003/03

Academic Degrees

  • TOHOKU UNIVERSITY
  • TOHOKU UNIVERSITY

Research Fields

  • Agricultural sciences;Animal life science;Animal production science

Research Keywords

  • oocyte
  • meiosis
  • fertilization
  • embryo
  • spindle
  • chromosome
  • evaluation of oocyte quality
  • Follicle development
  • supercooling preservation
  • mammal

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2019, Graduate Education (Master's Program) , 3Term, Innovation Practice
  2. 2019, Liberal Arts Education Program1, 3Term, Innovation Practice
  3. 2019, Undergraduate Education, Intensive, Laboratory Work in General Biology II
  4. 2019, Undergraduate Education, Intensive, Laboratory Work in Animal Reproduction
  5. 2019, Undergraduate Education, Academic Year, Graduation Thesis
  6. 2019, Graduate Education (Master's Program) , OutOfTerm(1st), Practice in Animal Germ cell Utilization
  7. 2019, Graduate Education (Master's Program) , OutOfTerm(1st), Practice in Animal Science
  8. 2019, Graduate Education (Master's Program) , 2Term, Animal Production Science I
  9. 2019, Graduate Education (Master's Program) , 4Term, Animal Production Science II

Research Activities

Academic Papers

  1. Phosphoric acid and phosphorylation levels are potential biomarkers indicating developmental competence of matured oocytes., Analyst, 144(5), 1527-1534, 2019
  2. The effects of human menstrual blood stem cells-derived granulosa cells on ovarian follicle formation in a rat model of premature ovarian failure., Microscopy research and technique, 2018
  3. Updating the markers for oocyte quality evaluation: intracellular temperature as a new index., Reproductive medicine and biology, 17(4), 434-441, 2018
  4. The effects of melatonin on colonization of neonate spermatogonial mouse stem cells in a three-dimensional soft agar culture system, STEM CELL RESEARCH & THERAPY, 8(1), 2017
  5. Expression of Six Proteins Causes Reprogramming of Porcine Fibroblasts Into Induced Pluripotent Stem Cells With Both Active X Chromosomes, JOURNAL OF CELLULAR BIOCHEMISTRY, 118(3), 537-553, 2017
  6. Expression of Six Proteins Causes Reprogramming of Porcine Fibroblasts Into Induced Pluripotent Stem Cells With Both Active X Chromosomes., Journal of cellular biochemistry, 118(3), 2017
  7. The effects of melatonin on colonization of neonate spermatogonial mouse stem cells in a three-dimensional soft agar culture system., Stem cell research & therapy, 8(1), 2017
  8. Comparison of the effects of BPA and BPAF on oocyte spindle assembly and polar body release in mice., Zygote (Cambridge, England), 24(2), 172-180, 2016
  9. Localization and quantitative analysis of Cx43 in porcine oocytes during in vitro maturation., Zygote (Cambridge, England), 24(3), 364-370, 2016
  10. Requirement for nuclear autoantigenic sperm protein mRNA expression in bovine preimplantation development, ANIMAL SCIENCE JOURNAL, 87(3), 457-461, 2016
  11. Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice, ENDOCRINOLOGY, 157(12), 4899-4913, 2016
  12. Requirement for nuclear autoantigenic sperm protein mRNA expression in bovine preimplantation development., Animal science journal = Nihon chikusan Gakkaiho, 87(3), 2016
  13. Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice., Endocrinology, 157(12), 2016
  14. Roles of epidermal growth factor (EGF)-like factor in the ovulation process., Reproductive medicine and biology, 15(4), 2016
  15. Expression of Focal Adhesion Kinase in Mouse Cumulus-Oocyte Complexes, and Effect of Phosphorylation at Tyr397 on Cumulus Expansion, MOLECULAR REPRODUCTION AND DEVELOPMENT, 82(3), 218-231, 2015
  16. Expression of focal adhesion kinase in mouse cumulus-oocyte complexes, and effect of phosphorylation at Tyr397 on cumulus expansion., Molecular reproduction and development, 82(3), 2015
  17. Distribution of tubulointerstitial nephritis antigen-like 1 and structural matrix proteins in mouse embryos during preimplantation development in vivo and in vitro., Zygote (Cambridge, England), 22(2), 2014
  18. C-type natriuretic peptide inhibits porcine oocyte meiotic resumption., Zygote (Cambridge, England), 22(3), 2014
  19. Quantitative analysis in LC3-II protein in vitro maturation of porcine oocyte., Zygote (Cambridge, England), 22(3), 2014
  20. Effect of single-oocyte culture system on in vitro maturation and developmental competence in mice., Reproductive medicine and biology, 13(3), 2014
  21. Selection of In Vitro-Matured Porcine Oocytes Based on Localization Patterns of Lipid Droplets to Evaluate Developmental Competence, J. Reprod. Dev., 59(4), 405-408, 20130801
  22. Quantitative analysis of LC3-II protein during in vitro maturation of porcine oocytes, 30(2), 20130401
  23. Distribution and association of mTOR with its cofactors, raptor and rictor, in cumulus cells and oocytes during meiotic maturation in mice., Molecular reproduction and development, 80(4), 2013
  24. Distribution of protein disulfide isomerase during maturation of pig oocytes, ANIMAL SCIENCE JOURNAL, 84(1), 15-22, 2013
  25. Distribution and association of mTOR with its cofactors, raptor and rictor, in cumulus cells and oocytes during meiotic maturation in mice, MOLECULAR REPRODUCTION AND DEVELOPMENT, 80(4), 334-348, 2013
  26. L-carnitine improves hydrogen peroxide-induced impairment of nuclear maturation in porcine oocytes, ANIMAL SCIENCE JOURNAL, 84(5), 395-402, 2013
  27. Incorporation of Phosphatase Inhibitor in Culture Prompts Growth Initiation of Isolated Non-Growing Oocytes, PLOS ONE, 8(11), 2013
  28. Distribution of protein disulfide isomerase during maturation of pig oocytes., Animal science journal = Nihon chikusan Gakkaiho, 84(1), 2013
  29. Selection of in vitro-matured porcine oocytes based on localization patterns of lipid droplets to evaluate developmental competence., The Journal of reproduction and development, 59(4), 2013
  30. L-carnitine improves hydrogen peroxide-induced impairment of nuclear maturation in porcine oocytes., Animal science journal = Nihon chikusan Gakkaiho, 84(5), 2013
  31. Incorporation of phosphatase inhibitor in culture prompts growth initiation of isolated non-growing oocytes., PloS one, 8(11), 2013
  32. Efficient Establishment of Pig Embryonic Fibroblast Cell Lines with Conditional Expression of the Simian Vacuolating Virus 40 Large T Fragment, Biosci. Biotechnol. Biochem., 76(7), 1372-1377, 20120723
  33. Distribution and Y397 phosphorylation of focal adhesion kinase on follicular development in the mouse ovary, CELL AND TISSUE RESEARCH, 347(2), 457-465, 2012
  34. Angiogenesis and Microvasculature in the Female Reproductive Organs: Physiological and Pathological Implications, CURRENT PHARMACEUTICAL DESIGN, 18(3), 303-309, 2012
  35. A New Human Spermatozoon Selection Method Based on Penetration of Cervical Mucus for Intracytoplasmic Sperm Injection, J.Mamm.Ova.Res., 29(1), 65-74, 2012
  36. Efficient Establishment of Pig Embryonic Fibroblast Cell Lines with Conditional Expression of the Simian Vacuolating Virus 40 Large T Fragment, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 76(7), 1372-1377, 2012
  37. Distribution and Y397 phosphorylation of focal adhesion kinase on follicular development in the mouse ovary., Cell and tissue research, 347(2), 2012
  38. Efficient establishment of pig embryonic fibroblast cell lines with conditional expression of the simian vacuolating virus 40 large T fragment., Bioscience, biotechnology, and biochemistry, 76(7), 2012
  39. Effect of Droplet Size and Number of Oocytes Examined on Mouse Oocyte Quality in In Vitro Maturation, J.Mamm.Ova.Res., 28(1), 53-60, 2011
  40. Evaluation of maturation competence of metaphase II oocytes in mice based on the distance between pericentriolar materials of meiotic spindle: distance of PCM during oocyte maturation., Journal of assisted reproduction and genetics, 28(2), 2011
  41. Adrenomedullin: A possible regulator of germinal vesicle breakdown, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 415(4), 691-695, 2011
  42. Adrenomedullin: a possible regulator of germinal vesicle breakdown., Biochemical and biophysical research communications, 415(4), 2011
  43. The Signal Transduction of Meiotic Progression in Mammalian Oocytes, J.Mamm.Ova.Res., 27(1), 21-26, 20100401
  44. Expression of FAK during mouse ovarian follicular growth and atresia, 27(2), 20100401
  45. Akt expression in mouse oocytes matured in vivo and in vitro, REPRODUCTIVE BIOMEDICINE ONLINE, 20(1), 35-41, 2010
  46. Lactate and Adenosine Triphosphate in the Extender Enhance the Cryosurvival of Rat Epididymal Sperm, JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE, 49(2), 160-166, 2010
  47. Lactate and adenosine triphosphate in the extender enhance the cryosurvival of rat epididymal sperm., Journal of the American Association for Laboratory Animal Science : JAALAS, 49(2), 2010
  48. Effect of hyaluronan to inhibit caspase activation in porcine granulosa cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 382(1), 160-164, 2009
  49. Development and spindle formation in rat somatic cell nuclear transfer (SCNT) embryos in vitro using porcine recipient oocytes, ZYGOTE, 17(3), 195-202, 2009
  50. Addition of a Phosphatase Inhibitor Prompts Growth Initiation of Isolated Primordial Follicle Oocytes in Culture, BIOLOGY OF REPRODUCTION, 191-191, 2009
  51. Effect of hyaluronan to inhibit caspase activation in porcine granulosa cells., Biochemical and biophysical research communications, 382(1), 2009
  52. Development and spindle formation in rat somatic cell nuclear transfer (SCNT) embryos in vitro using porcine recipient oocytes., Zygote (Cambridge, England), 17(3), 2009
  53. Protein kinase B (PKB/Akt) is required for the completion of meiosis in mouse oocytes., Developmental biology, 314(1), 2008
  54. Protein kinase B (PKB/Akt) is required for the completion of meiosis in mouse oocytes, DEVELOPMENTAL BIOLOGY, 314(1), 215-223, 2008
  55. Recent patents of TGF-beta family and VEGF associated with ovarian follicular development in mammals., Recent patents on DNA & gene sequences, 1(3), 2007
  56. Freezability of rat epididymal sperm induced by raffinose in modified Krebs-Ringer bicarbonate (mKRB) based extender solution, CRYOBIOLOGY, 55(3), 285-294, 2007
  57. Freezability of rat epididymal sperm induced by raffinose in modified Krebs-Ringer bicarbonate (mKRB) based extender solution., Cryobiology, 55(3), 2007
  58. Possible differentiation of mouse embryonic stem cells to germ cells by culture with undifferentiated gonads, 23(2), 20060401
  59. Detection of Fas ligand in the bovine oviduct., Animal reproduction science, 86(1-2), 2005
  60. Phosphatidylinositol 3-kinase and Akt participate in the FSH-induced meiotic maturation of mouse oocytes., Molecular reproduction and development, 69(1), 2004
  61. Molecular cloning of porcine growth differentiation factor 9 (GDF-9) cDNA and its role in early folliculogenesis: direct ovarian injection of GDF-9 gene fragments promotes early folliculogenesis., Reproduction (Cambridge, England), 128(5), 2004
  62. Expression of CD44 in Porcine Cumulus-Oocyte Complexes during In Vitro Oocyte Maturation, Journal of mammalian ova research, 19(3), 121-127, 20021001
  63. Expression of CD44 in Porcine Cumulus-Oocyte Complexes during In Vitro Oocyte Maturation., J.Mamm.Ova.Res., 19(3), 121-127, 2002

Invited Lecture, Oral Presentation, Poster Presentation

  1. What is the high quality oocyte?, Yumi Hoshino, Special seminar of University of Colorado Anschutz Medical Campus, 2019/06/13, With Invitation, University of Colorado Anschutz Medical Center, Colorado, USA
  2. Non-invasive assessment of developmental competence of mouse oocytes using Raman spectroscopy., Mika Ishigaki, Yumi Hoshino, Yukihiro Ozaki., The 26th International Conference on Raman Spectroscopy (ICORS 2018), 2018/08/29, Without Invitation, Korean Chemical Society, Jeju, Korea
  3. Key molecules active during meiotic maturation responsible for oocyte quality., Yumi Hoshino, RCAS/JAB International Symposium, Animal Biotechnology: From Genes to Cells, 2018/02/21, With Invitation, The Research Center for Animal Science (RCAS), Japanese Avian Bioresource Project Research Center (JAB), Hiroshima University (Hiroshima)
  4. Inhibition of mTOR signaling induces cumulus expansion and stimulates meiotic maturation of oocytes in mice., Yumi Hoshino, 2018/01/23, With Invitation, Monash University, Australia
  5. Pin1 functions during early cleavage in mouse embryo, Yumi Hoshino, Takuma Miyamoto, Tomoko Kawai, Takafumi Uchida, Masayuki Shimada, Fourth World Congress of Reproductive Biology, 2017/09/29, Without Invitation, Society for the Reproduction and Development, Okinawa Convention Center, Okinawa
  6. Oocyte evaluation using Bio-Raman microscope., Yumi Hoshino, The 54th Annual Meeting of the Biophysical Society of Japan, 2016/11/26, With Invitation, The Biophysical Society of Japan, Tsukuba International Congress Center
  7. How do we select high-quality oocyte?, Yumi Hoshino, The 15th Research Center for Mathematics on Chromatin Live Dynamics (RcMcD) Seminar, 2016/07/15, With Invitation, Research Center for Mathematics on Chromatin Live Dynamics, Higashi-hiroshima