YUMI HOSHINO

Last Updated :2019/12/02

Affiliations, Positions
Graduate School of Integrated Sciences for Life, ., Assistant Professor
E-mail
hoshimihiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Graduate School of Integrated Science for Life, Assistant Professor
  • 2015/11/01, 2019/03/31, Hiroshima University, Graduate School of Biosphere Science, Assistant Professor
  • 2011/10/01, 2012/09/30, Stanford University, School of Medicine, Visiting Assistant Professor
  • 2007/12/01, 2015/10/31, Tohoku University, Graduate School of Agricultural Science, Assistant Professor
  • 2007/04/01, 2007/11/30, Tohoku University, Graduate School of Agricultural Science, Postdoctoral Fellow
  • 2005/04/01, 2007/03/31, Tohoku University, Graduate School of Agricultural Science, JSPS Research Fellowship for Young Scientists

Educational Backgrounds

  • Tohoku University, Graduate School of Agricultural Science, Division of Life Sciences, Japan, 2003/04, 2006/03
  • Tohoku University, Graduate School of Agricultural Science, Division of Biological Resource Sciences, Japan, 2001/04, 2003/03

Academic Degrees

  • TOHOKU UNIVERSITY
  • TOHOKU UNIVERSITY

Research Fields

  • Agricultural sciences;Animal life science;Animal production science

Research Keywords

  • oocyte maturation
  • meiosis
  • fertilization
  • embryo
  • spindle
  • chromosome
  • evaluation of oocyte quality
  • Follicle development
  • supercooling preservation
  • mammal

Affiliated Academic Societies

  • Society for Reproduction and Development
  • Japanese Society of Animal Science
  • Japan Society for Ova Research
  • Japan Society of Fertilization and Implantation
  • The molecular Biology Society of Japan
  • The Biophysical Society of Japan
  • Quantum Life Science Society
  • Society for the Study of Reproduction

Educational Activity

Course in Charge

  1. 2019, Graduate Education (Master's Program) , 3Term, Innovation Practice
  2. 2019, Liberal Arts Education Program1, 3Term, Innovation Practice
  3. 2019, Undergraduate Education, Intensive, Laboratory Work in General Biology II
  4. 2019, Undergraduate Education, Intensive, Laboratory Work in Animal Reproduction
  5. 2019, Undergraduate Education, Academic Year, Graduation Thesis
  6. 2019, Graduate Education (Master's Program) , Second Semester, Preparing Future Faculty Course
  7. 2019, Graduate Education (Master's Program) , OutOfTerm(1st), Practice in Animal Germ cell Utilization
  8. 2019, Graduate Education (Master's Program) , OutOfTerm(1st), Practice in Animal Science
  9. 2019, Graduate Education (Master's Program) , 2Term, Animal Production Science I
  10. 2019, Graduate Education (Master's Program) , 4Term, Animal Production Science II

Research Activities

Academic Papers

  1. Proliferation and Differentiation of Mouse Spermatogonial Stem Cells on a Three-Dimensional Surface Composed of PCL/Gel Nanofibers, INTERNATIONAL JOURNAL OF MORPHOLOGY, 37(3), 1132-1141, 2019
  2. Phosphoric acid and phosphorylation levels are potential biomarkers indicating developmental competence of matured oocytes., Analyst, 144(5), 1527-1534, 2019
  3. The effects of human menstrual blood stem cells-derived granulosa cells on ovarian follicle formation in a rat model of premature ovarian failure., Microscopy research and technique, 82(6), 635-642, 2019
  4. Updating the markers for oocyte quality evaluation: intracellular temperature as a new index., Reproductive medicine and biology, 17(4), 434-441, 2018
  5. The effects of melatonin on colonization of neonate spermatogonial mouse stem cells in a three-dimensional soft agar culture system, STEM CELL RESEARCH & THERAPY, 8(1), 233, 2017
  6. Expression of Six Proteins Causes Reprogramming of Porcine Fibroblasts Into Induced Pluripotent Stem Cells With Both Active X Chromosomes, JOURNAL OF CELLULAR BIOCHEMISTRY, 118(3), 537-553, 2017
  7. Requirement for nuclear autoantigenic sperm protein mRNA expression in bovine preimplantation development, ANIMAL SCIENCE JOURNAL, 87(3), 457-461, 2016
  8. Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice, ENDOCRINOLOGY, 157(12), 4899-4913, 2016
  9. Comparison of the effects of BPA and BPAF on oocyte spindle assembly and polar body release in mice, ZYGOTE, 24(2), 172-180, 2016
  10. Localization and quantitative analysis of Cx43 in porcine oocytes during in vitro maturation, ZYGOTE, 24(3), 364-370, 2016
  11. Roles of epidermal growth factor (EGF)-like factor in the ovulation process., Reproductive medicine and biology, 15(4), 201-206, 2016
  12. Expression of Focal Adhesion Kinase in Mouse Cumulus-Oocyte Complexes, and Effect of Phosphorylation at Tyr397 on Cumulus Expansion, MOLECULAR REPRODUCTION AND DEVELOPMENT, 82(3), 218-231, 2015
  13. Effect of single-oocyte culture system on in vitro maturation and developmental competence in mice., Reproductive medicine and biology, 13(3), 153-159, 2014
  14. Distribution of tubulointerstitial nephritis antigen-like 1 and structural matrix proteins in mouse embryos during preimplantation development in vivo and in vitro, ZYGOTE, 22(2), 259-265, 2014
  15. C-type natriuretic peptide inhibits porcine oocyte meiotic resumption, ZYGOTE, 22(3), 372-377, 2014
  16. Quantitative analysis in LC3-II protein in vitro maturation of porcine oocyte, ZYGOTE, 22(3), 404-410, 2014
  17. Selection of In Vitro-Matured Porcine Oocytes Based on Localization Patterns of Lipid Droplets to Evaluate Developmental Competence, J. Reprod. Dev., 59(4), 405-408, 2013
  18. Quantitative analysis of LC3-II protein during in vitro maturation of porcine oocytes, 30(2), 2013
  19. Distribution of protein disulfide isomerase during maturation of pig oocytes, ANIMAL SCIENCE JOURNAL, 84(1), 15-22, 2013
  20. Distribution and association of mTOR with its cofactors, raptor and rictor, in cumulus cells and oocytes during meiotic maturation in mice, MOLECULAR REPRODUCTION AND DEVELOPMENT, 80(4), 334-348, 2013
  21. L-carnitine improves hydrogen peroxide-induced impairment of nuclear maturation in porcine oocytes, ANIMAL SCIENCE JOURNAL, 84(5), 395-402, 2013
  22. Incorporation of Phosphatase Inhibitor in Culture Prompts Growth Initiation of Isolated Non-Growing Oocytes, PLOS ONE, 8(11), 2013
  23. Efficient Establishment of Pig Embryonic Fibroblast Cell Lines with Conditional Expression of the Simian Vacuolating Virus 40 Large T Fragment, Biosci. Biotechnol. Biochem., 76(7), 1372-1377, 2012
  24. Distribution and Y397 phosphorylation of focal adhesion kinase on follicular development in the mouse ovary, CELL AND TISSUE RESEARCH, 347(2), 457-465, 2012
  25. Angiogenesis and Microvasculature in the Female Reproductive Organs: Physiological and Pathological Implications, CURRENT PHARMACEUTICAL DESIGN, 18(3), 303-309, 2012
  26. A New Human Spermatozoon Selection Method Based on Penetration of Cervical Mucus for Intracytoplasmic Sperm Injection, J.Mamm.Ova.Res., 29(1), 65-74, 2012
  27. Evaluation of maturation competence of metaphase II oocytes in mice based on the distance between pericentriolar materials of meiotic spindle, JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 28(2), 157-166, 2011
  28. Effect of Droplet Size and Number of Oocytes Examined on Mouse Oocyte Quality in In Vitro Maturation, J.Mamm.Ova.Res., 28(1), 53-60, 2011
  29. Adrenomedullin: A possible regulator of germinal vesicle breakdown, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 415(4), 691-695, 2011
  30. Effect of aminoguanidine in sperm DNA fragmentation in varicocelized rats: role of nitric oxide., Reproductive Sciences, 18(6), 545-550, 2011
  31. The Signal Transduction of Meiotic Progression in Mammalian Oocytes, J.Mamm.Ova.Res., 27(1), 21-26, 2010
  32. Lactate and Adenosine Triphosphate in the Extender Enhance the Cryosurvival of Rat Epididymal Sperm, JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE, 49(2), 160-166, 2010
  33. Akt expression in mouse oocytes matured in vivo and in vitro, REPRODUCTIVE BIOMEDICINE ONLINE, 20(1), 35-41, 2010
  34. Effects of aminoguanidine on infertile varicocelized rats: A functional and morphological study., Daru, 18(1), 51-56, 2010
  35. Effect of hyaluronan to inhibit caspase activation in porcine granulosa cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 382(1), 160-164, 2009
  36. Influence of the prostatic fluid from the first fractions of the ejaculates on the cryosurvival of poodle dog sperm., American Journal of Animal and Veterinary Science, 4(1), 14-20, 2009
  37. Development and spindle formation in rat somatic cell nuclear transfer (SCNT) embryos in vitro using porcine recipient oocytes, ZYGOTE, 17(3), 195-202, 2009
  38. Addition of a Phosphatase Inhibitor Prompts Growth Initiation of Isolated Primordial Follicle Oocytes in Culture, BIOLOGY OF REPRODUCTION, 191-191, 2009
  39. Morphological analysis of meiotic resumption in the oocyte of mice., Morphology, 4(1), 1-5, 2009
  40. Protein kinase B (PKB/Akt) is required for the completion of meiosis in mouse oocytes, DEVELOPMENTAL BIOLOGY, 314(1), 215-223, 2008
  41. Recent advances in understanding the morphological changes in the meiotic maturation in mammalian cumulus-oocyte complexes., Morphology, 2(1), 8-22, 2007
  42. Morphological aspects of porcine embryos reconstructed by somatic cell nuclear transfer., Morphology, 2(1), 23-27, 2007
  43. Freezability of rat epididymal sperm induced by raffinose in modified Krebs-Ringer bicarbonate (mKRB) based extender solution, CRYOBIOLOGY, 55(3), 285-294, 2007
  44. Recent patents of TGF-beta family and VEGF associated with ovarian follicular development in mammals., Recent patents on DNA & gene sequences, 1(3), 195-199, 2007
  45. Molecular basis of meiotic maturation and apoptosis of oocytes, sperm-oocyte interactions and early cleavage of embryos in mice, Role of phosphatidylinositol 3-kinase, Mos, Fas-Fas ligand, integrin alfa 6 and MAP kinase., YAKHTEH Medical Journal, 7(1), 98-114, 2005
  46. Detection of Fas ligand in the bovine oviduct., Animal reproduction science, 86(1-2), 71-88, 2005
  47. Fas ligand expression in the porcine oviduct., Thai Journal Veterinary Medicine, 35(1), 73-79, 2005
  48. Phosphatidylinositol 3-kinase and Akt participate in the FSH-induced meiotic maturation of mouse oocytes., Molecular reproduction and development, 69(1), 77-86, 2004
  49. Molecular cloning of porcine growth differentiation factor 9 (GDF-9) cDNA and its role in early folliculogenesis: direct ovarian injection of GDF-9 gene fragments promotes early folliculogenesis., Reproduction (Cambridge, England), 128(5), 537-543, 2004
  50. Expression of CD44 in Porcine Cumulus-Oocyte Complexes during In Vitro Oocyte Maturation., J.Mamm.Ova.Res., 19(3), 121-127, 2002

Publications such as books

  1. 2006, Gamete Biology: Emerging Frontiers on Fertility and Contraceptive Development, Cellular and molecular events during oocyte maturation in mammals: Molecules of cumulus-oocyte complex matrix and signalling pathways regulating meiotic progression, Nottingham University press, 2006, English, Naoko Kimura, Yumi Hoshino, Kiyoshi Totsukawa, Eimei Sato, ISBN-10: 1904761437, 548, 16

Invited Lecture, Oral Presentation, Poster Presentation

  1. What is the high quality oocyte?, Yumi Hoshino, Special seminar of University of Colorado Anschutz Medical Campus, 2019/06/13, With Invitation, University of Colorado Anschutz Medical Center, Colorado, USA
  2. Non-invasive assessment of developmental competence of mouse oocytes using Raman spectroscopy., Mika Ishigaki, Yumi Hoshino, Yukihiro Ozaki., The 26th International Conference on Raman Spectroscopy (ICORS 2018), 2018/08/29, Without Invitation, Korean Chemical Society, Jeju, Korea
  3. Key molecules active during meiotic maturation responsible for oocyte quality., Yumi Hoshino, RCAS/JAB International Symposium, Animal Biotechnology: From Genes to Cells, 2018/02/21, With Invitation, The Research Center for Animal Science (RCAS), Japanese Avian Bioresource Project Research Center (JAB), Hiroshima University (Hiroshima)
  4. Inhibition of mTOR signaling induces cumulus expansion and stimulates meiotic maturation of oocytes in mice., Yumi Hoshino, 2018/01/23, With Invitation, Monash University, Australia
  5. Pin1 functions during early cleavage in mouse embryo, Yumi Hoshino, Takuma Miyamoto, Tomoko Kawai, Takafumi Uchida, Masayuki Shimada, Fourth World Congress of Reproductive Biology, 2017/09/29, Without Invitation, Society for the Reproduction and Development, Okinawa Convention Center, Okinawa
  6. Oocyte evaluation using Bio-Raman microscope., Yumi Hoshino, The 54th Annual Meeting of the Biophysical Society of Japan, 2016/11/26, With Invitation, The Biophysical Society of Japan, Tsukuba International Congress Center
  7. How do we select high-quality oocyte?, Yumi Hoshino, The 15th Research Center for Mathematics on Chromatin Live Dynamics (RcMcD) Seminar, 2016/07/15, With Invitation, Research Center for Mathematics on Chromatin Live Dynamics, Higashi-hiroshima
  8. Spindle formation-related proteins responsible for oocyte quality, Yumi Hoshino, Lecture in University of LAquila, 2014/09, With Invitation, University of LAquila, LAquila (Italy)
  9. Inhibition of mTOR signaling induces cumulus expansion and stimulates meiotic maturation of oocytes in mice, Yumi Hoshino, Eimei Sato, The World Congress of Reproductive Biology 2014, 2014/09, Without Invitation, The World Congress of Reproductive Biology, Edinburgh (Scotland)
  10. Spindle formation-related proteins responsible for oocyte quality, Yumi Hoshino, The 3rd Korea-China-Japan Joint Symposium on Animal Reproduction, 2014/07, With Invitation, Korean Society of Animal Reproduction, Jeju (Korea)
  11. Evaluation of maturation competence of metaphase II oocytes in mice based on the distance between pericentriolar materials of meiotic spindle, Yumi Hoshino:, The 37th Naito Conference: Bioimaging – a paradigm shift for the life sciences, 2014/07, Without Invitation, The Naito Foundation, Niseko (Japan)
  12. Key molecules active during oocyte maturation responsible for oocyte quality, Yumi Hoshino, FertiLink 2010, 2010/10, With Invitation, FertiLink, Kyoto (Japan)
  13. Ultramorphological assessment of apoptosis using an in vitro co-culture system pig cumulus oocyte complex and granulosa cells (COCG layer) supplemented with hormone, Maria Grazia Palmerini, Woro Anindito Sri Tunjung, Akane Kadowaki, Elena Di Marco, Luigi Coppola, Yumi Hoshino, Eimei Sato, Guido Macchiarelli, The XXI International Symposium on Morphological Sciences (ICSMS), 2010/09, Without Invitation, International Symposium on Morphological Sciences, Taormina (Italy)
  14. Inhibition of mTOR induces cumulus expansion and meiotic maturation in mouse oocytes without gonadotropin stimulation, Yumi Hoshino, Yusuke Sato, Eimei Sato, The Society for Reproduction and Fertility Annual Conference 2010, 2010/07, Without Invitation, The Society for Reproduction and Fertility, Nottingham (UK)
  15. Functional role of Akt and mTOR in meiotic resumption and completion in mouse oocytes, Yumi Hoshino, 2nd Chungbuk National University and Tohoku University Joint Seminar on Animal Reproduction, 2010/04, Without Invitation, Tohoku University, Sendai, Miyagi
  16. Evaluation of maturation ability of metaphase II oocytes in mice based on the meiotic spindle form, Chizuka Sakai, Yumi Hoshino, Eimei Sato, 2nd Chungbuk National University and Tohoku University Joint Seminar on Animal Reproduction, 2010/04, Without Invitation, Tohoku University, Sendai, Miyagi
  17. Granulosa cells inhibit resumption of meiosis in oocytes, Yuki Hiradate, Yumi Hoshino, Eimei Sato, 2nd Chungbuk National University and Tohoku University Joint Seminar on Animal Reproduction, 2010/04, Without Invitation, Tohoku University, Sendai, Miyagi
  18. Focal adhesion kinase expression during ovarian follicular growth and atresia in mice, Masahiro Sakurai, Yumi Hoshino, Eimei Sato, 2nd Chungbuk National University and Tohoku University Joint Seminar on Animal Reproduction, 2010/04, Without Invitation, Tohoku University, Sendai, Miyagi
  19. Functional role of Akt and mTOR in meiotic resumption and completion, Yumi Hoshino, The International Ovarian Conference 2009, 2009/12, With Invitation, The International Ovarian Conference, Tokyo (Japan)
  20. Utilization of exogenous lactate by lactate dehydrogenase-C4 in the midpiece of rat epididymal sperm is essential for motility and oxidative activity, Hideaki Yamashiro, Masaaki Toyomizu, Nobuya Aono, Masahiro Sakurai, Fumiaki Nakazato, Akane Kadowaki, Masaki Yokoo, Yumi Hoshino, Eimei Sato, The 10th World Conference on Animal Production, 2008/11, Without Invitation, World Association of Animal Production, Cape Town (South Africa)
  21. Akt is functional in the completion of meiosis in mouse oocytes, Yumi Hoshino, Eimei Sato, The Society for Reproduction and Fertility Annual Conference 2008, 2008/06, Without Invitation, The Society for Reproduction and Fertility, Edinburgh (Scotland)
  22. Exogenous lactate and adenosine triphosphate in extender solution regulate the oxidative activity and enhance the freezability of rat epididymal sperm, Hideaki Yamashiro, Masaaki Toyomizu, Young-Joon Han, Masaki Yokoo, Hiroyuki Abe, Yumi Hoshino, Eimei Sato, The Society for Reproduction and Fertility Annual Conference 2008, 2008/06, Without Invitation, The Society for Reproduction and Fertility, Edinburgh (Scotland)
  23. Evaluation of culture medium for in vitro developmental competence in porcine in vitro matured oocytes, Yumi Hoshino, Hajime Abe, Takuya Wakai, Ken-ichi Yamanaka, Satoshi Sugimura, Eimei Sato, 14th World Congress on in vitro fertilization, 2007/09, Without Invitation, International Society for in Vitro Fertilization, Montreal (Canada)
  24. Complete meiosis in mouse oocytes is controlled by Akt, Yumi Hoshino, Atsushi Sugawara, Eimei Sato, The second congress of the Asian Association of Veterinary Anatomists, 2007/09, Without Invitation, Asian Association of Veterinary Anatomists, Bangkok (Thailand)
  25. Akt is required to complete meiosis in mouse oocytes, Yumi Hoshino, Eimei Sato, The 4th Canada-Japan Bilateral Workshop on Human Reproduction and Reproductive Biology, 2007/07, Without Invitation, Hirosaki (Japan)
  26. Development of capillary blood vessels during follicular development and its artificial control by VEGF gene constructs, Eimei Sato, Yumi Hoshino, The second congress of the Asian Association of Veterinary Anatomists, 2007, With Invitation, Asian Association of Veterinary Anatomists, Bangkok (Thailand)
  27. Osamu Takayama, Yumi Hoshino, Hiroshi Sasada, Eimei Sato, Downstream of Akt in mouse oocyte maturation, International Symposium: Cell Signaling in Gamete Activation – from Basic Research to ART–, 2006/11, Without Invitation, Tokyo Women's Medical University, Tokyo (Japan)
  28. Cellular features of oocytes associated with reproductive aging in mice, Naoko Kimura, Mari Suda, Yumi Hoshino, Eimei Sato, Kiyoshi Totsukawa, IV Meeting of Society for Biology of Reproduction Joint Polish-Japanese Seminar, 2005/09, Without Invitation, Society for Biology of Reproduction, Poland
  29. Distribution and expression of Akt/protein kinase B during oocyte meiotic maturation and preimplantation development in mice, Yumi Hoshino, Hiromichi Matsumoto, Eimei Sato, Society for the Study of Reproduction 37th Annual Meeting, 2004/08, Without Invitation, Society for the Study of Reproduction, Vancouver (Canada)
  30. Vitrification of immature bovine oocytes by step-wise exposure to cryoprotectants using a nylon mesh, Yasuyuki Abe, Yumi Hoshino, Hiroshi Sasada, Eimei Sato, Asian-Australian Association of Animal Production Societies 10th Registration, 2002/09, Without Invitation, Asian-Australian Association of Animal Production Societies, India

Awards

  1. 2015年08月, Japan Society for Reproductive Medicine RMB Excellent Paper Award, Japan Society for Reproductive Medicine, Effect of single-oocyte culture system on in vitro maturation and developmental competence in mice
  2. 2010年07月, Best Poster Award, Society for Reproduction and Fertility, Inhibition of mTOR induces cumulus expansion and meiotic maturation in mouse oocytes without gonadotropin stimulation.
  3. 2009年07月, Larry Ewing Memorial Trainee Travel Fund, Society for the Study of Reproduction
  4. 2004年08月, Larry Ewing Memorial Trainee Travel Fund, BC Research Institute for Children's and Women's Health, Society for the Study of Reproduction