MASAHIRO NAKAMORI

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Assistant Professor
Self-introduction
I investigate the physiological mechanism about neurological disease using the clinical experience.

Basic Information

Major Professional Backgrounds

  • 2005/04/01, 2007/03/31, Hiroshima University Hospital, junior resident
  • 2007/04/01, 2009/03/31, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, senior resident
  • 2009/04/01, 2010/03/31, National Hospital Organization Higashi-Hiroshima Medical Center, staff
  • 2010/04/01, 2014/03/31, Hiroshima University Hospital, Department of Clinical Neuroscience and Therapeutics, medical doctor
  • 2014/04/01, 2020/03/31, Suiseikai Kajikawa Hospital, Department of Neurology, Chief of medical doctor
  • 2020/04/01, 2022/03/31, Hiroshima University Hospital, Department of Clinical Neuroscience and Therapeutics, Assistat Professor

Educational Backgrounds

  • Hiroshima University, School of Medicine , Japan, 1999/04, 2005/03
  • Hiroshima University Graduate School of Biomedical and Health Sciences, Department of Clinical Neuroscience and Therapeutics, Neurology, Japan, 2010/04, 2014/03

Academic Degrees

  • Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Neurology

Affiliated Academic Societies

  • Japanese Society of Internal Medicine, 2005/04
  • Japanese Society of Neurology, 2007/04
  • The Japan Stroke Society, 2007/04
  • The Japan Academy of Neurosonology, 2007/09
  • The Japanese Society of Neuropathology, 2010/11
  • Japanese Headache Society, 2011/06
  • Japan Society of Dementia Research, 2011/09
  • Japanese Society of Clinical Neurophysiology, 2011/09
  • The Japan Epilepsy Society, 2012/06
  • World Stroke Organization, 2012/09
  • Movement Disorder Society, Japan, 2012/10
  • The Japanese Society of Dysphagia Rehabilitation, 2012/10
  • Japanese Society for Clinical Nutrition and Metabolism, 2013/04
  • The Japan Geriatrics Society, 2013/10
  • The Japanese Society for Neuroimmunology, 2013/12
  • The Japan Neuroscience Society, 2014/04
  • The Society of Swallowing and Dysphagia of Japan, 2014/04
  • The Japanese Society of Neuroradiology, 2016/04
  • American Heart Association, 2019/03
  • The Japan Society of Logopedics and Phoniatrics, 2019/04
  • Japanese Society of Neurological Therapeutics, 2021/05
  • The Japan Society of Human Genetics, 2021/07
  • Jananese Society of Bioinformatics, 2022/10
  • International Parkinson and Movement Disorder Society, 2023/05

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Intensive, Introduction to clinical clerkship
  2. 2024, Undergraduate Education, Year, Medical Neuroscience III
  3. 2024, Undergraduate Education, Intensive, Practice for medical research
  4. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  5. 2024, Undergraduate Education, First Semester, Internal Medicine I
  6. 2024, Undergraduate Education, 1Term, Dysphagia Rehabilitation
  7. 2024, Undergraduate Education, 1Term, Dysphagia Rehabilitation
  8. 2024, Undergraduate Education, 1Term, Dysphagia Rehabilitation

Research Activities

Academic Papers

  1. Diagnostic value of lower extremity ultrasonographic nerve enlargement for differentiating demyelinating Charcot-Marie-Tooth disease from chronic inflammatory demyelinating polyneuropathy, Journal of the Neurological Sciences, 2024
  2. Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging, Journal of NeuroVirology, 2024
  3. The Long-Term Effects of Heated Tobacco Product Exposure on the Central Nervous System in a Mouse Model of Prodromal Alzheimer's Disease, Scientific Reports, 14(1), 227, 20240102
  4. ★, Prospective observational study for the comparison of screening methods including tongue pressure and repetitive saliva swallowing with detailed videofluoroscopic swallowing study findings in acute stroke patients, Journal of the American Heart Association, 2023
  5. ★, Association between motor symptoms of Parkinson's disease and swallowing disorders, Neurological Sciences, 2023
  6. A Large-Scale Whole-Genome Analysis of HTLV-1-Associated Myelopathy Identified Hereditary Spastic Paraplegias, Neurology Genetics, 2023
  7. Neuromuscular ultrasonography in autoimmune peripheral neuropathies, Neurosonology, 36(3), 138-143, 20231231
  8. Apolipoprotein E genotype-dependent accumulation of amyloid β in APP-knock-in mouse model of Alzheimer's disease, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 683, 20231126
  9. ★, Swallowing sound index analysis using electronic stethoscope and artificial intelligence for patients with Parkinson's disease, JOURNAL OF THE NEUROLOGICAL SCIENCES, 454, 120831, 20231115
  10. ★, Detailed findings of videofluoroscopic examination among patients with Parkinson's disease on the effect of cervical percutaneous interferential current stimulation, FRONTIERS IN NEUROLOGY, 14, 1279161, 20231107
  11. Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment, FRONTIERS IN NEUROSCIENCE, 17, 1250547, 20231023
  12. Association between Carotid Wall Shear Stress-Based Vascular Vector Flow Mapping and Cerebral Small Vessel Disease, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 30(9), 1165-1175, 20230901
  13. ★, Swallowing sound evaluation using an electronic stethoscope and artificial intelligence analysis for patients with amyotrophic lateral sclerosis, FRONTIERS IN NEUROLOGY, 14, 1212024, 20230803
  14. CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis, AMERICAN JOURNAL OF HUMAN GENETICS, 110(7), 1086-1097, 20230706
  15. Nerve Ultrasonography for the Diagnosis and Evaluation of Neuralgic Amyotrophy, INTERNAL MEDICINE, 62(12), 1843-1847, 20230615
  16. Reversible Brain Atrophy in Cryptogenic New-onset Refractory Status Epilepticus, INTERNAL MEDICINE, 62(12), 1835-1842, 20230615
  17. ★, Mitochondrial trifunctional protein deficiency caused by HADHB gene mutation (c.1175C>T) characterized by higher brain dysfunction followed by neuropathy, presented gadolinium enhancement on brain imaging in an adult patient, FRONTIERS IN NEUROLOGY, 14, 1187822, 20230613
  18. ★, Impact of neck percutaneous interferential current sensory stimulation on swallowing function in patients with Parkinson's disease: A single-arm, open-label study protocol, CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS, 33, 101158, 20230610
  19. A case of natalizumab-associated progressive multifocal leukoencephalopathy followed by immune reconstitution inflammatory syndrome with difficulty in the timing of immunotherapy, Clinical and Experimental Neuroimmunology, 14(2), 110-115, 202305
  20. Paradoxical effects of levetiracetam in people with epilepsy with rhythmic epileptiform discharges, EPILEPSY & BEHAVIOR, 143, 109225, 20230430
  21. Encephalopathy after COVID-19 vaccination during treatment with nivolumab: A case report, CLINICAL NEUROLOGY AND NEUROSURGERY, 226, 107632, 20230215
  22. ★, Peak expiratory flow, but not tongue pressure, can predict pneumonia development in older adults, EUROPEAN GERIATRIC MEDICINE, 14(1), 211-217, 20230214
  23. Immediate and 6-month seizure outcomes following first and second SARS-CoV2 mRNA vaccinations: A multicenter study with a nationwide survey, EPILEPSY & BEHAVIOR, 139, 109070, 20230103
  24. Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching, PARKINSONISM & RELATED DISORDERS, 106, 105227, 202301
  25. Isolated neurohypophysial sarcoidosis involving cavernous sinus mimicking malignant tumor, NMC Case Report Journal, 31-35, 20221231
  26. Progressive Multifocal Leukoencephalopathy in Relapsed Ph plus Acute Lymphoblastic Leukemia after Cord Blood Transplantation and Blinatumomab Treatment: A Case Report and Literature Review, ACTA HAEMATOLOGICA, 145(6), 655-660, 20220727
  27. Diffusion-Weighted Imaging Hyperintensities in Acute and Subacute-Phase Intracerebral Hemorrhage, J Stroke Cerebrovasc Dis., 31(8), 106549, 20220512
  28. ★, Clinical factors predicting voluntary driving cessation among patients with Parkinson's disease, Behavioural Neurology, 4047710, 20220320
  29. ★, Amyloid beta is internalized via macropinocytosis, an HSPG- and lipid raft-dependent and Rac1-mediated process, Frontiers in Molecular Neuroscience, 15, 804702, 20220211
  30. ★, Association of ankle-brachial index with cognitive decline in patients with lacunar infarction, PLoS ONE, 17(2), e0263525, 20220204
  31. Assessment of serum IgG titers to various periodontal pathogens associated with atrial fibrillation in acute stroke patients, J Stroke Cerebrovasc Dis., 31(3), 106301, 20220113
  32. Characteristics and Prognostic Factors of Swallowing Dysfunction in Patients with Lateral Medullary Infarction, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 30(12), 10622, 20210925
  33. External cervical resorption detected via cone-beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease: A case report, CLINICAL CASE REPORTS, 9(7), e04415, 20210706
  34. ★, Relationship between tongue pressure and dysphagia diet in patients with acute stroke, PLOS ONE, 16(6), e0252837, 20210604
  35. Impact of anatomical variations on ultrasonographic reference values of lower extremity peripheral nerves, MUSCLE & NERVE, 63(6), 890-896, 20210401
  36. Utility of Magnetic Resonance Spectroscopy for the Progression of Neurological Symptoms in Lenticulostriate Artery Territory Infarction, J Stroke Cerebrovasc Dis, 30(6), 105747, 20210327
  37. ★, Association between stroke lesions and videofluoroscopic findings in acute stroke patients., J Neurol., 268(3), 1025-1035, 202103
  38. Low dose contrast-induced encephalopathy during diagnostic cerebral angiography., Internal Medicin, 60(4), 629-633, 20210215
  39. Cnm-positive Streptococcus mutans and diffusion-weighted imaging hyperintensities in acute intracerebral hemorrhage, Eur J Neurol., 28(5), 1581-1589, 20210111
  40. ★, Serum IgG titers against periodontal pathogens are associated with cerebral hemorrhage growth and 3-month outcome, PLoS ONE., 15(10), e0241205, 20201028
  41. ★, Delayed Swallowing Reflex is Overlooked in Swallowing Screening Among Acute Stroke Patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 29(12), 105303, 20201009
  42. Association between periodontal disease due to Campylobacter rectus and cerebral microbleeds in acute stroke patients, PLOS ONE, 15(10), e0239773, 20201008
  43. ★, Lobar microbleeds are associated with cognitive impairment in patients with lacunar infarction, SCIENTIFIC REPORTS, 10(1), 16410, 20201002
  44. Simplified cough test can predict the risk for pneumonia in patients with acute stroke, PLOS ONE, 15(9), e0239590, 20200929
  45. Patient Health Questionnaire-9 predicts the functional outcome of stroke patients in convalescent rehabilitation ward, BRAIN AND BEHAVIOR, 10(12), e01856, 20200920
  46. ★, Tongue thickness measured by ultrasonography is associated with tongue pressure in the Japanese elderly, PLOS ONE, 15(8), e0230224, 20200807
  47. Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients., PLoS ONE., 15(8), e0237185, 20200806
  48. Infant critical head injury could be a remote cause of middle-aged cerebral amyloid angiopathy, INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT, 22, 20200527
  49. Serum immunoglobulin G antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 200(3), 302-309, 20200324
  50. ★, Prediction of independent gait in acute stroke patients with hemiplegia using the Ability for Basic Movement Scale II score., Eur Neurol., 83(1), 49-55, 20200325
  51. ★, Utility of Minimum Apparent Diffusion Coefficient Ratios in Alberta Stroke Program Early CT Score Regions for Deciding on Stroke Therapy., J Stroke Cerebrovasc Dis., 28(5), 1371-1380, 20190222
  52. Screening for Fabry Disease in Japanese Patients with Young-Onset Stroke by Measuring a-Galactosidase A and Globotriaosylsphingosine., J Stroke Cerebrovasc Dis., 27(12), 3563-3569, 20180907
  53. ★, Subarachnoid hemorrhage after transient global amnesia caused by cerebral venous congestion: case report, BMC Neurology., 18(1), 36, 20180406
  54. Blood Pressure Variability in Acute Ischemic Stroke: Influence of Infarct Location in the Insular Cortex., Eur Neurol., 79(1-2), 90-99, 20180115
  55. ★, Maximum tongue pressure is associated with swallowing dysfunction in ALS patients., Dysphagia., 32(4), 542-547, 20170419
  56. Development of a candy-sucking test for evaluating oral function in elderly patients with dementia: A pilot study., Geriatrics Gerontology International., 17(11), 1977-1981, 20170222
  57. ★, Prediction of pneumonia in acute stroke patients using tongue pressure measurements., PLoS ONE., 11(11), e0165837, 20161101
  58. ★, The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments., Neuropathology and Applied Neurobiology., 42(7), 639-653, 20161026
  59. The multidisciplinary swallowing team approach decreases pneumonia onset in acute stroke patients., PLoS ONE., 11(5), e0154608, 20160503
  60. ★, Tongue thickness evaluation using ultrasonography can predict swallowing function in amyotrophic lateral sclerosis patients., ClinNeurophysiol., 127(2), 1669-1674, 201602
  61. ★, Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles., Neuropathology and Applied Neurobiology., 40(4), 489-501, 20140430
  62. Fiber Type-Specific Expression of Low-Density Lipoprotein Receptor-Related Protein 6 in Human Skeletal Muscles., Pathobiology., 81(2), 94-99, 20140123
  63. ★, Molecular markers for granulovacuolar degeneration are present in rimmed vacuoles., PLoS ONE., 8(11), e80995, 20131128
  64. Characterization and distribution of adaptor protein containing a PH domain, PTB domain and leucine zipper motif (APPL1) in Alzheimer's disease hippocampus: an immunohistochemical study., Brain Research., 1494, 118-124, 20130204
  65. ★, Cyclin-dependent kinase 5 immunoreactivity for granulovacuolar degeneration., Neuroreport., 23(15), 867-872, 20121024
  66. Cerebral amyloid angiopathy with a varied hemorrhage pattern on T2*-weighted magnetic resonance image, Internal Medicine, 48(9), 735-736, 20090501

Invited Lecture, Oral Presentation, Poster Presentation

  1. Amyloid beta is internalized via HSPG, lipid raft-dependent and Rac1-mediated macropinocytosis, Keyoumu Nazere, Tetsuya Takahashi, Naoyuki Hara, Kazuki Muguruma, Masahiro Nakamori, Yu Yamazaki, Hiroyuki Morino, Hirofumi Maruyama, 2023/06/02, Without Invitation, English
  2. Low risk of catching the common cold in Parkinson's disease patients: Propensity score matching, Shuichiro Neshige, Shiro Aoki, Tomohisa Nezu, Masahiro Nakamori, Yu Yamazaki, Hirofumi Maruyama, 2023/05/31, Without Invitation, English
  3. Incidence and risk factor of a paradoxical effect of levetiracetam for epileptic seizures, Yoshiko Takebayashi, Shuichiro Neshige, Takeo Shishido, Yuki Hayashi, Akiko Segawa, Masahiro Nakamori, Tomohisa Nezu, Shiro Aoki, Yu Yamazaki, Hiroki Ueno, Tomohiko Ohshita, Koji Iida, Hirofumi Maruyama, 2022/09/20, Without Invitation, English
  4. Seizure outcomes following SARS-CoV2 mRNA vaccination in people with epilepsy: multicenter study and nationwide survey, Megumi Nonaka, Shuichiro Neshige, Haruka Ishibashi, Yoshiko Takebayashi, Shiro Aoki, Masahiro Nakamori, Yu Yamazaki, Takeo Shishido, Dai Agari, Kazuhide Ochi, Koji Iida, Hirofumi Maruyama, 2022/09/20, Without Invitation, English
  5. Clinical factors predicting voluntary driving cessation among patients with Parkinson's disease, Hidetada Yamada, Masahiro Nakamori, Tomohisa Nezu, Teppei Kotozaki, Juri Kitamura, Tomohiko Ohshita, Yoshimasa Sueda, Hirofumi Maruyama, 2022/07/21, Without Invitation, English
  6. Quantitative videofluorographic evaluation of swallowing class 0j and 0t foods of Japanese Dysphagia Diet 2013, Chiho Takeda, Mitsuyoshi Yoshida, Masahiro Nakamori, Mineka Yoshikawa, Jun Kayashita, Kazuhiro Tsuga, The 2nd World Dysphagia Summit, 2021/08/19, Without Invitation, English
  7. Lobar cerebral microbleeds are associated with cognitive impairment in lacunar infarction patients, Masahiro Nakamori, Naohisa Hosomi, Keisuke Tachiyama, Teppei Kamimura, Hayato Matsushima, Yuki Hayashi, Eiji Imamura, Shinichi Wakabayashi, Hirofumi Maruyama, ESO-WSO Conference, 2020/11/07, Without Invitation, English
  8. Utility of MR spectroscopy for progression of neurological symptoms in penetrating artery territory infarction, Yuji Shiga, Tomohisa Nezu, Masahiro Nakamori, Naohisa Hosomi, Yuji Akiyama, Keisuke Tachiyama, Teppei Kamimura, Yuki Hayashi, Hayato Matsushima, Eiji Imamura, Naoto Kinoshita, Shiro Aoki, Hiroki Ueno, Tomohiko Ohshita, Shinichi Wakabayashi, Fumiyuki Yamasaki, Kaoru Kurisu, Kazuo Awai, Hirofumi Maruyama, ESO-WSO Conference, 2020/11/07, Without Invitation, English, Vienna, Austria
  9. Serum IgG titers of periodontal pathogens predict hemorrhage growth and 3-month outcome in patients with cerebral hemorrhage, Masahiro Nakamori, Naohisa Hosomi, Hiromi Nishi, Yuji Shiga, Hayato Matsushima, Shiro Aoki, Tomohisa Nezu, Naoto Kinoshita, Eiji Imamura, Shinichi Wakabayashi, Hirofumi Maruyama, Internal Stroke Conference, 2019/02/06, Without Invitation, English
  10. High baPWV is associated with cognitive decline in lacunar infarction patients, Masahiro Nakamori, Hayato Matsushima, Yuta Maetani, Eiji Imamura, Shinichi Wakabayashi, Yasuyo Mimori, Hirofumi Maruyama, 2018/05/23, Without Invitation, English
  11. Investigation of the relationship between videofluoroscopic examination and tongue pressure using a balloon-type device in acute stroke patients, Masahiro Nakamori, Eiji Imamura, Hayato Matsushima, Yuta Maetani, Satomi Kushitani, Shinichi Wakabayashi, Mineka Yoshikawa, Kazuhiro Tsuga, Toshikazu Nagasaki, Naohisa Hosomi, Hirofumi Maruyama, The 23th World Congress of Neurology, 2017/09/17, Without Invitation, English
  12. Raft derived vesicles are another component of neurofibrillary tangle, Masahiro Nakamori, Tetsuya Takahashi, Tomokazu Nishikawa, Tomoyasu Matsubara, Chengyu Li, Yukari Shinozaki, Yoshito Nagano, Hirofumi Maruyama, Masayasu Matsumoto, 2014/09/11, Without Invitation, English
  13. Immunoreactivity for Cyclin-dependent kinase 5 in Granulovacuolar degeneration, Masahiro Nakamori, Tetsuya Takahashi, Yu Yamazaki, Takashi Kurashige, Yoshito Nagano, Takemori Yamawaki, Masayasu Matsumoto, The 13th Asian Oceanian Congress of Neurology, 2012/06/04, Without Invitation, English

Awards

  1. 2021/11/06, Phoenix Outstanding Researcher Award, Hiroshima University
  2. 2012/06, Young Investigator Encouragement Grant, The 13th Asian Oceanic Congress of Neurology

External Funds

Acceptance Results of Competitive Funds

  1. 2024, 2027
  2. 2023/12, 2024/11
  3. 2023/10, 2024/09
  4. 2023/04, 2024/03
  5. 2023/04, 2028/03
  6. 2023/04, 2026/03
  7. 2022, 2024
  8. 2022/12, 2023/11
  9. 2022/11, 2023/10
  10. 2022/08, 2023/07
  11. 2021/12, 2023/11
  12. 2021/04
  13. 2021/04, 2024/03
  14. 2021/04, 2024/03

Social Activities

History as Peer Reviews of Academic Papers

  1. 2023, Neurology and Clinical Neuroscience, Others
  2. 2023, Frontiers in Neurology, Others
  3. 2023, Journal of Prosthodontic Research, Others
  4. 2023, Sicentific Reports, Others
  5. 2023, BMC Neurology, Others
  6. 2023, BMC Neurology, Others
  7. 2023, Sicentific Reports, Others
  8. 2023, Frontier in Neurology, Editor
  9. 2022, Brain and Behavior, Others
  10. 2020, Brain and Behavior, Others
  11. 2020, Dysphagia, Others
  12. 2020, Gerontology, Others
  13. 2020, Brain and Behavior, Others
  14. 2020, Journal of Pediatric Genetics, Others
  15. 2018, BMJ Open, Others
  16. 2018, Geriatrics and Gerontology International, Others