Hidemi Kurihara

Last Updated :2019/12/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), ., Professor
E-mail
hkurihiroshima-u.ac.jp
Other Contact Details
1-2-3,Kasumi,Minami-ku,Hiroshima, Japan
TEL : (+81) FAX : (+81)

Basic Information

Major Professional Backgrounds

  • 1983/01/01, 1984/03/31, Okayama University, Research Assistant
  • 1984/01/01, 1992/03/31, Okayama University, Lecturer
  • 1989/11/21, Emory University, GA,USA, Dental Research Center, Visiting Researcher
  • 1991/01/01, Eastman Dental Center, Visiting Researcher
  • 1992/04/01, 1995/08/31, Okayama University, Associate Professor
  • 1995/09/01, Hiroshima University, Faculty of Dentistry, Professor
  • 2002/04/01, 2019/03/31, Hiroshima University Graduate School of Medical Sciences, Departmento of Periodontal Medicine, Professor
  • 2002/04/01, 2004/03/31, Hiroshima University Dental Hospital, Director
  • 2004/04/01, 2008/03/31, Hiroshima University, Faculty of Dentistry, Dean
  • 2008/04/01, 2009/03/31, Hiroshima University, Vice Director
  • 2009/08/01, Taipei Medical University, Visiting Professor
  • 2011/04/01, Hiroshima University Hospital, Chief Deputy Director
  • 2012, 2019/03/31, Institute of Biomedical and Health Sciences, HIroshima University, Division of Applied Life Science, Department of Periodontal Medicine, Professor

Educational Backgrounds

  • Hiroshima University, Faculty of Dentistry, Japan, 1974/04, 1980/03

Academic Degrees

  • Doctor of Philosophy in Dental Science, Okayama University

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Periodontology

Research Keywords

  • periodontitis
  • auto antibody
  • gene diagnosis
  • aggressive periodontitis
  • periodontal disease prevention
  • periodontal tissue regeneration
  • mesenchymal stem cell
  • brain-derived neurotrophic factor
  • Drug-induced gingival hyperplasia
  • rheumatoid arthritis

Affiliated Academic Societies

  • Japanese Society of Periodontology, 1978/04
  • The Japanese Society of Conservative Dentistry, 1980/04
  • Japanese Society for Evidence and the Dental Professional, 2007/11
  • Japanese Association for Oral Biology, 1984/05
  • Japanese Dental Education Association, 2005/08
  • Japanese Society for Immunology, 1994/01
  • Japanese Society for Bacteriology, 1988/04
  • Japanese Society for Regenerative Medicine, 2004/03
  • The Japanese Society of Human Genetics, 1996/10
  • Japanese Tissue Culture Association, 1996/10
  • The Japanese Geriatrics Society, 2013/02
  • Japanese College of Rheumatology, 2013/11
  • Japanese Society for Infection Prevention and Control, 2013/09

Educational Activity

Course in Charge

  1. 2019, Undergraduate Education, 4Term, Overview of Dentistry
  2. 2019, Undergraduate Education, 2Term, Periodontology
  3. 2019, Undergraduate Education, 1Term, Topics in Denral Research
  4. 2019, Undergraduate Education, 3Term, Periodontology
  5. 2019, Undergraduate Education, Academic Year, Advanced Course in Applied Oral Biology and Medicine
  6. 2019, Undergraduate Education, 1Term, Basic Practice of Periodontics
  7. 2019, Undergraduate Education, 2Term, Basic Practice of Periodontics
  8. 2019, Undergraduate Education, 3Term, Examination and Diagnosis
  9. 2019, Undergraduate Education, 4Term, Seminar and Practice of Periodontal Medicine
  10. 2019, Undergraduate Education, 1Term, International Future Dentistry with the Outcomes of Researches
  11. 2019, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  12. 2019, Undergraduate Education, First Semester, Lifestyle-related Dentistry /Geriatric Dentistry
  13. 2019, Undergraduate Education, 2Term, General Seminar on Clinical Dentistry
  14. 2019, Undergraduate Education, Academic Year, Clinical Practice (Preventive Dentistry)
  15. 2019, Undergraduate Education, Academic Year, Clinical Practice (Periodontics)
  16. 2019, Undergraduate Education, Academic Year, Clinical Practice (Oral Clinical Examination)
  17. 2019, Undergraduate Education, First Semester, Lifestyle-related Dentistry /Geriatric Dentistry
  18. 2019, Undergraduate Education, 1Term, Oral Health Management B
  19. 2019, Undergraduate Education, First Semester, Overview of Oral Engineering
  20. 2019, Undergraduate Education, First Semester, Lifestyle-related Dentistry /Geriatric Dentistry
  21. 2019, Undergraduate Education, 1Term, Oral Health Management
  22. 2019, Graduate Education (Master's Program) , Second Semester, Advanced lecture on preventive medicine for evidence-based health guidance (II)
  23. 2019, Graduate Education (Master's Program) , Second Semester, Advanced lecture on preventive medicine for evidence-based health guidance (II)
  24. 2019, Graduate Education (Master's Program) , First Semester, Advanced lecture on oral health sciences
  25. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Periodontal Medicine
  26. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Periodontal Medicine
  27. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced research on Periodontal Medicine
  28. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Periodontal Medicine
  29. 2019, Graduate Education (Master's Program) , 3Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance B
  30. 2019, Graduate Education (Master's Program) , First Semester, Lecture on Oral Health Sciences

Research Activities

Academic Papers

  1. The expressions of claudin-1 and E-cadherin in junctional epithelium, JOURNAL OF PERIODONTAL RESEARCH, 45(4), 579-582, 201008
  2. FGF-2 Stimulates Periodontal Regeneration: Results of a Multi-center Randomized Clinical Trial, JOURNAL OF DENTAL RESEARCH, 90(1), 35-40, 201101
  3. Proteome analysis of proteins related to aggressive periodontitis combined with neutrophil chemotaxis dysfunction, JOURNAL OF CLINICAL PERIODONTOLOGY, 38(4), 310-317, 201104
  4. Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration, TISSUE ENGINEERING PART A, 17(7-8), 955-967, 201104
  5. Polarization-dependent Ti K X-ray absorption and emission studies of Ti2O3 single crystal, JOURNAL OF ELECTRON SPECTROSCOPY AND RELATED PHENOMENA, 184(3-6), 184-187, 201104
  6. A family study of a mother and daughter with increased susceptibility to early-onset periodontitis : Microbiological immunological host defensive, and genetic analysis, Journal of Periodontology, 61, 12, 19900401
  7. Serum immunogloblin G antibody to periodontal bacteria, Advanced Dental Research, 2, 2, 19880401
  8. Calcium-dependent protein kinase C activity of neutrophils in localized juvenile periodontitis, Infection and Immunity, 61(8), 3137-3142, 19930401
  9. Role of cytokine in the induction of adhesion molecules on cultured human gingival fibroblast, J. Periodontol, 230-235, 19940401
  10. Risk factors of periodontal disease involving host defense mechanisms-A case report of acute necrotizing ulcerative periodontitis-, New Zealand Soc Periodontol=, 77, 28-33, 19940401
  11. An atypical site in HLA-DQB1 detected in leprosy patients., Int J Lepr=, 62, 293-294, 19940401
  12. Acute necrotizing gingivitis-Risk factors involving host defense mechanisms-, Periodontology 2000, 6, 116-124, 19940401
  13. Isolation and characterization of a 53 kDa majour cell envelope protein antigen from Treponema denticola ATCC 35405, J. Periodontal. Res., 29(1), 70-78, 19940401
  14. Assessment of interleukin-6 in the pathogenesis of periodontal disease, J. Periodontol, 65(2), 147-153, 19940401
  15. A microbiological and immunological study of endodontic-periodontic lesions., J. Endodontics, 21(12), 617-621, 19950401
  16. The response of human gingival fibroblasts to prostaglandins, J. Periodontal. Res., 30(5), 303-311, 19950401
  17. Studis of the phenotypic and functional characterization of peripheral blood lymphocytes from patients with early-onset periodontitis, J. Periodontol, 66(5), 391-396, 19950401
  18. Clinical and laboratory studies on a patient with rapidly progressive periodontitis and their family members. A case report, J. Periodontol, 66(5), 403-412, 19950401
  19. Distribution of black-pigmented Prevotella and Porphyromonas species in the dentition of moderate periodontitis patients, Microbial Ecology in Health and Disease, 8, 159-169, 19950401
  20. Immunological, genetic, and microbiological study of family members manifesting eraly-onset periodontitis, J. Periodontol, 67(3), 254-263, 19960401
  21. Host defensive functions in a family manifesting early-onset periodontitis patients, Microbial Ecology in Health and Disease, 67(4), 433-422, 19960401
  22. Immunological, genetic, and microbiological study of family members manifesting early-onset periodontitis., J. Periodontol, 67, 254-263, 19960401
  23. Host defensive functions in a family manifesting early-onset periodontitis., J. Periodontol, 67, 433-442, 19960401
  24. New attachment to periodontlly deseased root surfaces treated with hydrochloric acid., Oral Medicine and Pathology, 1, 23-28, 19960401
  25. Ultrastrucural and immunocytochemical characterization of the bone-single crystal sapphire implant interface in the rat of maxilla., Medicine and Pathology, 1, 84-87, 19960401
  26. HLA class II genotypes associated with early-onset periodontitis : DQB1 molecule, J. Periodontol, 67, 888-894, 19960401
  27. Glucose-mediated alteration of cellular function in human periodontal ligament cells., Journal of Dental Research, 75(9), 1664-1671, 19960401
  28. Assessment of in vitro interleukin-2-producing capacity of peripheral blood lymphocytes from patients with periodontitis., J. Clin. Periodontol., 24(1), 44-50, 19970401
  29. Molecular cloning and characterization of the gene encoding 53 kDa outer membrane protein of Porphyromonas gingivalis., Microbios, 92, 47-57, 19970401
  30. The regulatory effect of fermentable sugar levels on the production of leukotoxin by Actinobacillus actinomycetemcomitans, FEMS Microbiology Letters, 146, 161-166, 19970401
  31. Characterization of Bacteroides forsyhus isolates., Clin Microbiol, 35(6), 1378-1381, 19970401
  32. Host defensive, immunological, and microbiological observations of an early-onset periodontitis patient with virus-associated hemophagocytic syndrome, J. Periodontol, 68(12), 1223-1230, 19970401
  33. Immunocytochemical and immunochemical study of emamelins, using anibodies against porcine 89-kDa enamelin and its N-terminal synthetic peptide, in porcine tooth germs., Cell Tissue Res., 293, 313-325, 19980401
  34. T cell responses to 53-kDa outer membrane protein of Porphyromonas gingivalis in humans with early-onset periodontitis., Human Immunology, 59, 635-643, 19980401
  35. The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans is a cytolethal distending toxin, Infect Immune, 66, 5008-5019, 19980401
  36. Effect of glycyrrhetinic acid on the viability of human gingival fibroblasts., J. Korean Academy of Periodontology, 28, 453-463, 19980401
  37. Expression of osteoprotegrin(osteoclastogenesis inhibitory factor)in cultures of human dental mesenchymal cells and epithelial cells, Journal of Bone and Mineral Research, 14, 1486-1492, 19990401
  38. Platelet-activating factor in gingival crevicular fluid from periodontitis patients as a potential clinical disease activity marker, Journal of the International Academy of Periodontology, 1, 60-64, 19990401
  39. Effects of ageing on proliferative ability, and the expression of secreted protein, acidic and rich in cysteine(SPARC)and osteoprotegerin(osteoclastogenesis inhibitory factor)in cultures of human periodontal ligament cells, Mech. Ageing Dev., 117, 69-77, 20000401
  40. Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils, 62, 385-394, 20000401
  41. Clinical periodontal findings and microflora profiles in children with chronic neutropenia under supervised oral hygiene, J. Periodontol, 72, 945-952, 20010401
  42. Molecular cloning and characterization of rat trp homologues from brain, Molecular Brain Research, 64(1), 41-51, 19990101
  43. Mediation by platelate-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in rabbit and human neutrophils, 62, 385-394, 20000401
  44. New attachment to periodontally diseasedroot surfaces treated with hydrochloric acid, Oral Medicine Pathology, 23-28, 19960401
  45. Clinical evaluation of a dental rinse containing aluminum lactate for treatment of dental hypersensitivity, Journal of Clinical Dentistry, 912, 19960401
  46. Host defensive functions in a family manifesting early-onset periodontitis, Journal of Periodontology, 433-442, 19960401
  47. Immunological, genetic, and microbiological study of family members manifesting early-onsetperiodontitis, Journal of Periodontology, 254-263, 19960301
  48. Glucose-mediated alteration of cellular function in human periodontal ligament cells, Journal of Dental Research, 1664-1671, 19960901
  49. Characterization of Bacteroides forsythus isolates, Journal of Clinical Microbiology, 1378-1381, 19970601
  50. Assessment of in vitro interleukin-2-producing capacity of peripheral blood lymphocytes from patients with periodontitis, Journal of Clinical Periodontology, 44-50, 19970101
  51. The reguratory effect of fermentable sugar levels on the production of leukotoxin by Actinobacillus actinomycetemcomitans, FEMS Microbiology Letters, 161-166, 19970101
  52. Molecular cloning and characterization of the gene encoding 53 kDa outer membrane protein of Porphyromonas gingivalis, Microbios, 47-57, 19970401
  53. Host defensive, immunological, and microbiological observation of an early-onset periodontitis patient with virus-associated hemophagocytic syndrome, Journal of Periodontology, 1223-1230, 19971201
  54. Differential effects of various growth factors and cytokines on the synthesis of DNA, type I collagen, laminin, fibronectin, osteonectin/SPARC and alkaline phosphatase by human pulp cells in culture., Journal of Cellular Physiology, 194-205, 19980201
  55. Immunocytochemical and immunochemical study of emamelins, using anibodies against porcine 89-kDa enamelin and its N-terminal synthetic peptide, in porcine tooth germs, CELL Tissue Research, 313-325, 19980801
  56. T cell responses to 53-kDa outer membrance protein of Porphyromonas gingivalis in humans with early-onset periodontitis, Human Immunology, 635-643, 19980101
  57. The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans, Infect. Immun., 91-100, 19980101
  58. Comparative study of two outer membrane protein genes from Porphyromonas gingivalis, Microbios, 91-100, 19980401
  59. Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in rabbit and human neutrophils, 62(4), 385-394, 20001001
  60. Platelet-activating factor in gingival crevicular fluid from periodontitis patients as a potential clinical disease activity marker, Journal of the International Academy of Periodontology, 1, 60-64, 19990401
  61. Molecular cloning and characterization of rat trp homologues from brain, Mol. Brain Res., 64(1), 41-51, 19990101
  62. Mycolic acid composition of Bacterionema matruchotii grown in shaking culture., J. Osaka Univ. Dent Sch., 115-121, 19820401
  63. Fatty acid composition in phenol extracts from Actinomyces species., J. Dent. Res., 1282-1286, 19821101
  64. Amphipathic antigen from Actinomyces viscosus., FEMS Microbiol. Lett., 267-269, 19840401
  65. Serum immunoglobulin G antibody to periodontal bacteria, Adv Dent Res, 339-345, 19881101
  66. Cell surface protein antigen from Wolinella recta ATCC33238T., J. Clin. Microbiol., 1210-1217, 19890601
  67. Purification and characterization of two major outer membrane proteins from Porphyromonas gingivalis., Dentistry in Japan, 29-34, 19900401
  68. A family study of mother amd daughter with increased susceptibility to early-onset periodontitis: microbiological, immunological, host defensive and genetic analyses., J. Periodontol, 755-765, 19901201
  69. Isolation and partial characterization of a 39 kDa major outer membrane protein of Actinobacillus actinomycetemcomitans Y4., FEMS Microbiol. Lett., 85-90, 19910101
  70. Monoclonal antibody to a specific antigen from Wolinella recta ATCC33238., FEMS Microbiol. Lett., 33-36, 19910701
  71. Molecular cloning and sequence analysis of an antigen gene tdpA of Treponema denticola., Infect. Immun., 1941-1947, 19910601
  72. Humoral immune response to an antigen from Porphyromonas gingivalis 381 in periodontal disease., Infect. Immun., 2758-2762, 19910801
  73. Effect of Ca2+ on the binding of Actinobacillus actinomycetemcomitans leukotoxin and the cytotoxicity to promyelocytic leukemia HL-60 cells., Biochen Mol Biol Int, 899-905, 19930401
  74. Antigenic properties of Campylobacter rectus(Wolinella recta) major S-layer proteins., FEMS Microbiol. Lett., 275-280, 19930401
  75. Calcium-dependent protein kinase C activity of neutrophils in localized juvenile periodontitis., Infect. Immun., 3137-3142, 19930801
  76. Abnormal proportion of gd Tcells in peripheral blood is frequently detected in patients with periodontal disease., J. Periodontol, 963-967, 19930101
  77. Association of Actinobacillus actinomycetemcomitans leukotoxin with nucleic acids on the bacteria cell surface., Infect. Immun., 4878-4884, 19931101
  78. Molecular cloning of the S-layer protein gene of Campylobacter rectus ATCC33238., FEMS Microbiol. Lett., 13-18, 19940401
  79. Isolation and characterization of a 53 kDa major cell envelope protein antigen from Treponema denticola ATCC35405., J. Periodontal. Res., 70-78, 19940101
  80. Assessment of interleukin-6 in the pathogenesis of periodontal disease., J. Periodontol, 147-153, 19940201
  81. Role of cytokine in the induction of adhesion molecules on cultured human gigival fibroblasts., J. Periodontol, 230-235, 19940301
  82. Heat shock protein 60 (Gro EL) from Porphyromonas gingivalis : Molecular cloning and sequence analysis of its gene and purification of the recombinant protein., FEMS Microbiol. Lett., 129-136, 19941101
  83. Risk factors of periodontal disease involving host defense mechanisms-A case report of acute necrotizing uncerative periodontitis-., New Zealand Soc Periodontol=, 28-33, 19940401
  84. An atypical site in HLA-DQBI detected in leprosy patients., Int J Lepr=, 293-294, 19940401
  85. Biochemical properties of the major outer membrane proteins of Porphyromonas gingivalis., Microbios, 247-252, 19940101
  86. Molecular basis of leukocyte adhesion molecules in early-onset periodontitis patients with decreased CD11/CD18 expression on leukocytes., J. Periodontol, 949-957, 19940101
  87. Cytokine-dependent synergistic regulation of interleukin-8 production from human gingival fibroblasts., J. Periodontol, 1002-1007, 19941101
  88. Stimulatory effects of Actinobacillus actinomycetemcomitans leukotoxin on the protein phosphorylation in the HL-60 promyelocytic leukemia cells., Jpn. J. Med. Sci. Biol., 312-313, 19940401
  89. Clinical, microbiological and host defense parameters associated with a case of localized prepubertal periodontitis., J. Clin. Periodontol., 56-62, 19950101
  90. Expression of the hepatocyte growth factor gene during chick limb development., Dev Dyn, 80-90, 19950101
  91. Clinical and laboratory studies on a patient with rapidly progressive periodontitis and their family members. A case report., J. Periodontol, 403-412, 19950501
  92. A microbiological and immunological study of endodontic-periodontic lesions, Journal of Endodontics, 617-621, 19951201
  93. Response of human gingival fibroblasts to prostaglandins., Journal of Periodontal Research, 303-311, 19950901
  94. Studies on the phenotypic and functional characterization of peripheral blood lymphocytes from patients with early-onset periodontitis., Journal of Periodontology, 391-396, 19950501
  95. Distribution of black-pigmented Prevotella and Porphyromonas species in the dentition of moderate periodontitis patiants, Microbial Ecology in Health and Disease, 159-169, 19950401
  96. Ultrastructual and immunocytechemical characterization of the bone-single crystal saahire implant interface in the rat maxilla, Oral Medicine Pathology, 84-89, 19960401
  97. Molecular cloning and characterization of rat trp homologues from brain, Molecular Brain Research, 41-51, 19990101
  98. Exprssion of osteoprotegrin (osteoclastogenesis inhibitory factor) in cultures of human dental mesenchymal cells and epithelial cells, Journal of Bone and Mineral Research, 1486-1492, 19990901
  99. Platelet-activating factor in gingival crevicularfluid from periodontitis patients as a potential clinical disease activity marker, J Int Acad Periodontol, 60-64, 19990401
  100. Chemotactic response of periodontal ligament cells decreases with donor age: association with reduced expression of c-fos, Oral Disease, 337-343, 19990101
  101. Adherence of Bacteroides forsythus to host cells, Microbios, 115-126, 20000401
  102. Effects of ageing on proliferative ability, and the expression of secreted protein, acidic and rich in cysteine (SPARC) and osteoprotegein (osteoclastogenesis inhibitory factor) in cultures of human periodontal ligament cells, Mech. Ageing Dev., 69-77, 20000801
  103. Mediation by platelet-activating factor of 12-hydroxycicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils., 385-394, 20000101
  104. Defective calcium influx factor activity in neutrophils from patients with localized juvenile periodontitis, J. Periodontol, 797-802, 20000501
  105. Clinical periodontal findings and microflora profiles in children with chronic neutropenia under supervised oral hygiene., J. Periodontol, 945-952, 20010701
  106. Nitric oxide synthase activity in neutrophils from patients with localized aggressive periodontitis., J. Periodontol, 1052-1058, 20010801
  107. Immunodetection of noncollagenous matrix proteins during periodontal tissue regeneration, J. Periodontal. Res., 205-213, 20010801
  108. Identification and characterization of B-cell epitopes of a 53-kDa outer membrane protein from Porphyromonas gingivalis, Oral Microbiol Immunol, 73-78, 20010401
  109. Transforming growth factor-beta1 and basic fibroblast growth factor modulate osteocalcin and osteonectin/SPARC syntheses in vitamin-D-activated pulp cells, J. Dent. Res., 1653-1659, 20010701
  110. Ultrastructural and immnucytochemical characteristics of the bone sapphire implant interface in the rat maxilla., 1, 68-75, 19960401
  111. New attachment to periodontally deseased root surfaces treated with hydrochloric acid., 1, 23-28, 19960401
  112. Adherence of Bacteroides forsythus to host cells, Microbios, 101, 115-126, 19990401
  113. Platelet-activating factor in gingival crevicular fruid from periodontitis patients as a potential clinical disease activity marker, J. International Academy of Periodontology, 2(1), 64-66., 19990401
  114. Platelet-activating factor in gingival crevicular fluid from periodontitis patients as a potential clinical disease activity marker, Journal of International Academy of Periodontology, 1, 60-64, 19990401
  115. Platelet-activating factor in gingival crevicular fluid from periodontitis patients as a potential clinical disease activity marker., J Int Acad Periodontol, 2, 60-4, 19990401
  116. New attachment to periodontally diseased root surfaces treated with hydrochloric acid., oral Med Pathol, 1, 23-8, 19960401
  117. Clinical periodontal findings and microflora profiles in children with chronic neutropenia under supervised oral hygiene, J. Periodontol, 72(7), 945-952, 20010701
  118. Adherence of Bacteroides forsythus to host cells, Microbios, 101(399), 115-126, 20000401
  119. Differential effects of various growth factos and cytokines on the syntheses of DNA, type I collagen, laminin, fibronectin, osteonectin/secreted protein, acidic and rich in cysteine (SPARC) , and alkaline phosphatase by human pulp cells in culture, J Cell Physiol, 174(2), 194-205, 19980201
  120. Transforming growth factor-b1 and basic fibroblast growth factor modulate osteocalcin and osteonectin/SPARC syntheses in vitamin D-activated pulp cells, J. Dent. Res., 80(7), 1653-1659, 20010701
  121. Expression of IL-1b and IL-8 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans, Cytokine, 14(3), 152-161, 20010501
  122. Effects of ageing on proliferative ability, and the expressions of secreted protein, acidic and rich in cysteine (SPARC) and osteoprotegerin (osteoclasogenesis inhibitory factor) in cultures of human periodontal ligament cells, Mech. Ageing Dev., 117(1-3), 69-77, 20000801
  123. Adherence of Bacteroides forsythus to host cells, Microbios, 101(399), 115-126, 20000401
  124. Expression of osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human dental mesenchymal cells and epithelial cells, J. Bone Miner. Res., 14(9), 1486-1492, 19990901
  125. Differential effects of various growth factos and cytokines on the syntheses of DNA, type I collagen, laminin, fibronectin, osteonectin/secreted protein, acidic and rich in cysteine (SPARC) , and alkaline phosphatase by human pulp cells in culture, J Cell Physiol, 174(2), 194-205, 19980201
  126. Differential effects of various growth factors and cytokines on the syntheses of DNA, type I collagen, laminin, fibronectin, osteonectin/secreted protein, acidic and rich in cysteine (SPARC), and alkaline phosphatase by human pulp cells in culture., J. Cell. Phys., 174, 194-205., 19980401
  127. Acute necrotizing ulcerative gingivitis: risk factors involving host defense mechanisms. . 1994 Oct;6:116-24., Periodontol 2000, 116-124, 19940101
  128. Neurotrophins in Cultured Cells from Periodontal Tissues., J. Periodontol, 74, 76-84, 20030401
  129. Relationship between periodontal disease and diabetic retinopathy., Diabetes Care, 27(2), 615, 20040201
  130. Prevalence of Cytolethal distending toxin production in periodontopathogenic bacteria. R.Yamano, M.Ohara, S.Nishikubo, T.Fujiwara, T.Kawamoto, Y.Ueno, H.Komatsuzawa, K.Okuda, H.Kurihara, H.Suginaka, E.Oswald, K.Tanne, M.Sugai. J. Clin. Microbiol. 41: 1391-1398. 2003., J. Clin. Microbiol., 41, 1391-1398, 20030401
  131. An N-terminal segment of the active component of bacterial genotoxin cytolethal distending toxin B (CDTB) directs the CDTB into the nucleus., J. Biol. Chem., 278, 50671-50681, 20030401
  132. Actinobacillus actinomycetemcomitans CDT insuces cell cycle arrest in primary culture of human gingival fibroblasts. M.Ohara, Y.Ueno, H.Shiba, S.Nishikubo, M.Ikura, H.Kurihara, H.Komatsuzawa, M.Sugai. Dentistry in Japan. 40: 18-22. 2004., Dentistry in Japan, 40, 18-22, 20040401
  133. Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans, Molecular Microbiology, 50(4), 1125-1139, 20030901
  134. Photoinduced Change in Birefringence and Optical Switching at Near-Infrared Region Based on Photochemical Phase Transition of Azobenzene Liquid Crystals, Mol. Cryst. Liq. Cryst., 441, 173-184, 20050401
  135. Effect of Intensity of Actinic Light and Temperature on Photochemical Phase Transition of Azobenzene Liquid Crystals Probed by a Near-Infrared Laser Beam, Mol. Cryst. Liq. Cryst., 443, 229-238, 20050401
  136. The effect of extracellular calcium ion on gene expression of bone-related proteins in human pulp cells., J Endodntics, 29(2), 104-107, 20030401
  137. Syntheses of prostaglandin E2 and E-cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans., Inflammation, 27(6), 341-349, 20030401
  138. Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells., Cell Biology Internathional, 28(10), 675-682, 20040401
  139. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins., Cell Biology Internathional, 29(2), 111-117, 20050401
  140. Brain-derived neurotrophic factor enhances periodontal tissue regeneration., Tissue Engineering, 11(9-10), 1618-1629, 20050401
  141. Human autologous serum obtained using a completely closed bag system as a substitute for foetal calf serum in human mesenchymal stem cell cultures., Cell Biology Internathional, 30(6), 521-524, 20060301
  142. Behavior of transplanted bone marrow-derived mesenchymal stem cells in periodontal defects., J. Periodontology, 77(6), 1003-1007, 20060601
  143. Proliferative ability and alkaline phosphatase activity with in vivo cellular aging in human pulp cells., J. Endod., 29(1), 9-11, 20030401
  144. Effects of overexpression of basic helix-loop-helix transcription factor Dec1 on osteogenic and adipogenic differentiation of mesenchymal stem cells., Eur. J. Cell Biol., 85(5), 423-431, 20060401
  145. Characteristics of periodontal ligament subpopulations obtained by sequential enzymatic digestion of rat molar periodontal ligament., BONE, 38, 420-426, 20060401
  146. Molecular Markers Distinguish Bone Marrow Mesenchymal Stem Cells from Fibroblasts., Biochem. Biophys. Res. Commun., 332(1), 297-303, 20050401
  147. Effects of overexpression of basic helix-loop-helix transcription factor Dec1 on osteogenic and adipogenic differentiation of mesenchymal stem cells., European Journal of Cell Biology, 85, 423-431, 20060401
  148. Regulation of IL-8 by Irsogladine maleate is involved in abolishment of actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication., Cytokine, 34, 271-277, 20060401
  149. Irsogladine maleate influences the response of gap junctional intercellular communication and IL-8 of human gingival epithelial cells following periodontopathogenic bacterial challenge., Biochem. Biophys. Res. Commun., 333, 502-507, 20050401
  150. CD38 expression in neutrophils from patients with localized aggressive periodontitis., J. Periodontol, 76, 1960-1965, 20050401
  151. CD38 cleavage in fMLP- and IL-8 induced chemotaxis is dependent on p38 MAP kinase but independent p44/42 MAP kinase., Cell. Signal., 17, 167-175, 20050401
  152. Differential effects of growth factors and cytokines on the synthesis of SPARC, DNA, fibronectin and alkaline phosphatase activity in human periodontal ligament cells., Cell. Biol. Int., 28, 281-286, 20040401
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  306. Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts., Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts., 283(23), 2008
  307. [Clinical trial of periodontal tissue regeneration]., [Clinical trial of periodontal tissue regeneration]., 66(5), 2008
  308. Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells., Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells., 79(12), 2008
  309. RUNX3 has an oncogenic role in head and neck cancer., RUNX3 has an oncogenic role in head and neck cancer., 4(6), 2009
  310. Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death., Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death., 221(3), 2009
  311. The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics., The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics., 36(6), 2010
  312. Characteristics of high-molecular-weight hyaluronic acid as a brain-derived neurotrophic factor scaffold in periodontal tissue regeneration., Characteristics of high-molecular-weight hyaluronic acid as a brain-derived neurotrophic factor scaffold in periodontal tissue regeneration., 17(7-8), 2011
  313. Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis., Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis., 4, 2012
  314. Brain-Derived Neurotrophic Factor Inhibits Peptidoglycan-Induced Inflammatory Cytokine Expression in Human Dental Pulp Cells, INFLAMMATION, 40(1), 240-247, 201702
  315. Xenotransplantation of interferon-gamma-pretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration, STEM CELL RESEARCH & THERAPY, 8, 20170426
  316. A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation, JOURNAL OF IMMUNOLOGICAL METHODS, 445, 31-36, 201706
  317. MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration, JOURNAL OF DENTAL RESEARCH, 96(9), 984-991, 201708
  318. Prevalence of Torus Mandibularis in Young Healthy Dentate Adults, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 75(12), 2593-2598, 201712
  319. Effect of local bone marrow stromal cell administration on ligature-induced periodontitis in mice, JOURNAL OF ORAL SCIENCE, 59(4), 629-637, 201712

Publications such as books

  1. 1991, Antibiotic therapy in crevicular regions for treatment of periodontal disease , Quintessence Publishing Co. = Ltd., 1991
  2. 1994, Molecular Pathogenesis of periodontal Disease , American Society for Microbiology, 1994
  3. 1994, Leukocyte adhesion molecules CD11/CD18 and their role in periodontal diseases; In Molecular Pathogenesis of Periodontal Disease , American Society for Microbiology, 1994
  4. 2006/05, periodontal tissue regeneration by transplantation of mesenchymal stem cells (clinical trial) , 2006, 05

Invited Lecture, Oral Presentation, Poster Presentation

  1. Muliphasic Discussion of Periodontal Treatment in Super-Aged Society, Hidemi Kurihara, 58th Autumn Meetiong of Japanese Society of Periodontology, 2015/09/13, With Invitation, Japanese Society of Periodontology, Hamamatsu city
  2. Reconsideration of Periodontal Medicine Research: Interface between Epidemiological Findings and Pathogenic Mechanisms, Hidemi Kurihara, 62nd JADR Annual Meeting, 2014/12/04, With Invitation, Japanese Association for Dental Reserch, Osaka city
  3. Update on Cytokine and Cell Therapy for Periodontal Tissue Regeneration, Hidemi Kurihara, Taiwan Academy of Periodontology (TAP) Annual Meeting of 2014, 2014/11/09, With Invitation, Tawan Academy of Periodontology, Kaohsiung, Taiwan
  4. Cell Therapy for Periodontal Tissue Regeneration, Hidemi Kurihara, AAP 100th Annual Meeting, 2014/09/27, With Invitation, American Academy of Periodontology, San Francisco, USA
  5. Oral Health Condition is deeply related to Every Stage of Women’s Life Mother’s Oral Health Controls their Children’s Life, Hidemi Kurihara, The 7th National Scientific Meeting in Pediatric Dentistry, 2014/02/09, With Invitation, Indonesia Society of Pediatric Dentistry, Surabaya, Indonesia
  6. Cell based Therapy for Periodontal Tissue Regeneration, Hidemi Kurihara, AAP 98th Annual Meeting, 2012/10/01, With Invitation, American Academy of Periodontology, Los Angeles
  7. Potential of Malassez Epithelial Cells in Periodontal Regeneration, Hidemi Kurihara, 2001/10, With Invitation
  8. Clumps of a mesenchymal stem cell/extracellular matrix complex induces periodontal tissue regeneration, 2017/09, Without Invitation
  9. Effects of brain-derived neurotrophic factor (BDNF) as an adjunct to non-surgical periodontal treatment on ligature-induced periodontitis in dogs, 2017/09, Without Invitation
  10. Elucidation of the role of NR4A1 in CsA induced gingival overgrowth, 2017/09, Without Invitation
  11. Involvement of C5a in the progression of experimental arthritis in SKG mice induced by Porphyromonas gingivalis infection, 2017/12, Without Invitation