Tooru Hiyama

Last Updated :2018/12/03

Affiliations, Positions
Health Service Center, ., Associate Professor
E-mail
tohiyamahiroshima-u.ac.jp
Other Contact Details
HEALTH SERVICE CENTER, HIROSHIMA UNIVERSITY, 1-7-1, KAGAMIYAMA, HIGASHIHIROSHIMA 739-8521, JAPAN, Japan
TEL : (+81)82-424-6191 FAX : (+81)82-422-7156

Basic Information

Major Professional Backgrounds

  • 2012/06/01, Hiroshima University, Health Service Center, Associate Professor
  • 2007/04/01, 2012/05/30, Hiroshima University, Health Service Center, Research associate
  • 2002/10/01, 2007/03/31, Hiroshima University, Health Service Center, Research Assistant
  • 1999/04/01, 2002/09/30, National Sanatorium Kamo Hospital, Department of Internal Medicine, Medical Doctor
  • 1993/04/01, 1995/03/31, Miyoshi Medical Association Hospital, Department of Internal Medicine, Medical Doctor
  • 1991/06/01, 1993/03/01, Hiroshima University, Hospital, Resident

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1996/04, 1999/03
  • Hiroshima University, Faculty of Medicine, Japan, 1985/04, 1991/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Gastroenterology

Research Keywords

  • medical risk management
  • health Service of university
  • gastrointestinal endoscopy

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2018, Liberal Arts Education Program1, 1Term, Introduction to Student Wellness
  2. 2018, Graduate Education (Master's Program) , Second Semester, Support Theory and Applications in Medical andHealth Area I
  3. 2018, Graduate Education (Master's Program) , Second Semester, Advanced lecture on preventive medicine for evidence-based health guidance (II)
  4. 2018, Graduate Education (Master's Program) , Second Semester, Advanced lecture on preventive medicine for evidence-based health guidance (II)

Research Activities

Academic Papers

  1. Early diagnosis of Helicobacter pylori infection in Vietnamese patients with acute peptic ulcer bleeding: a prospective study, Gastroenterol Res Pract, 2017, 3845067, 2017
  2. Clinical usefulness of the VS classification system using magnifying endoscopy with blue laser imaging for early gastric cancer, Gastroenterol Res Pract, 2017, 3649705, 2017
  3. Causes of delayed diagnoses of cancers in Japan from the viewpoint of malpractice litigations, Dig Liver Dis, 48, 687-691, 2016
  4. The performance of a modified Glasgow Blatchford Score in predicting clinical interventions in patients with acute nonvariceal upper gastrointestinal bleeding: a Vietnamese prospective multi center cohort study, Gut Liver, 10(3), 375-381, 2016
  5. Long-term prognosis after endoscopic submucosal dissection for early gastric cancer in super-elderly patients, Surg Endosc Other Interevent Tech, 30(10), 4321-4329, 2016
  6. Risk factors for esophageal stenosis after entire circumferential endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma, Surg Endosc Other Inetervent Tec, 30(9), 4049-4056, 2016
  7. The number of criminal prosecutions of physicians for medical negligence related to gastroenterology is on the rise in Japan, Scand J Gastroenterol, 50(5), 619-620, 2015
  8. Rate of unintended Helicobacter pylori eradication in the Vietnamese, Helicobacter, 20, 156-157, 2015
  9. Interobserver and intraobserver agreement for gastric mucosa atrophy, BMC Gastroenterol, 15, 95, 2015
  10. Differences in K-ras and mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients, BMC Gastroenterol, 14, 203, 2014
  11. Clinical outcomes of endoscopic submucosal dissection for superficial Barrett's adenocarcinoma, Gastrointest Endosc, 80(2), 239-245, 2014
  12. Value of a new stick-type rapid urine test for the diagnosis of Helicobacter pylori infection in the Vietnamese population, World J Gastroenterol, 20(17), 5087-5091, 2014
  13. Outcome of endoscopic submucosal dissection for gastric neoplasm in relationship to endoscopic classification of submucosal fibrosis, Gastric Cancer, 16(3), 404-410, 2013
  14. Clinicopathologic features of Japanese hyperplastic/serrated polyposis syndrome, J Gastroenterol Hepatol, 28(11), 1693-1698, 2013
  15. Relationship between Endoscopic and Histologic Gastric Atrophy and Intestinal Metaplasia, HELICOBACTER, 18(2), 151-157, 2013
  16. Change in malpractice claims in Japanese gastroenterological practice, Am J Gastroenterol, 107(1), 143-144, 2012
  17. Compliance with standard precautions among gastrointestinal endoscopists and andendoscopy nurses in Japan, Am J Infect Control, 40(1), 80, 2012
  18. Removal of a sewing needle penetrating the wall of the third portion of the duodenum by double- balloon endoscopy, Clin J Gastroenterol, 5(1), 79-81, 2012
  19. Clinical validity of endoscopic submucosal dissection for submucosal invasive gastric cancer: a single-center study, Gastric Cancer, 15(1), 97-105, 2012
  20. Clinical features of pharyngeal intraepithelial neoplasias and outcomes of treatment by endoscopic submucosal dissection, Gastrointest Endosc, 76(6), 1095-1103, 2012
  21. Diagnostic yield of capsule endoscopy vs. double-balloon endoscopy for patients who have undergone total enteroscopy with obscure gastrointestinal bleeding, Hepatogastroenterology, 59(116), 955-959, 2011
  22. Advantages of endoscopic submucosal dissection versus endoscopic oblique aspiration mucosectomy for superficial esophageal tumors, J Gastroenterol Hepatol, 26(2), 275-280, 2011
  23. Genetic pathways of multiple esophageal squamous cell carcinomas, Oncol Rep, 25(2), 453-459, 2011
  24. Prevalence and impact of musculoskeletal pain in Japanese gastrointestinal endoscopists: A controlled study, World J Gastroetnerol, 17(11), 1488-1493, 2011
  25. Characteristics of esophageal squamous cell carcinomas and lugol-voiding lesions in patients with head and neck squamous cell carcinoma, J Clin Gastroenterol, 44(2), e27-33, 2010
  26. Synchronous and subsequent lesions of serrated adenomas and tubular adenomas of the colorectum, Pathobiology, 77(5), 273-277, 2010
  27. Natural Course of Lugol-Voiding Lesions in Patients with Superficial Esophageal Squamous Cell Carcinoma, Digestion, 82(1), 60-65, 2010
  28. Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma, Cancer Sci, 100(6), 1075-1081, 20091001
  29. Metachronous multiple esophageal squamous cell carcinomas and Lugol-voiding lesions after endoscopic mucosal resection, ENDOSCOPY, 41(4), 304-309, 200904
  30. Meta-analysis used to identify factors associated with the effectiveness of proton pump inhibitors against non-erosive reflux disease, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 24(8), 1326-1332, 200908
  31. Cheilitis granulomatosa as an early manifestation of Crohn's disease, Clin J Gastroenterol, 2, 190-193, 20091001
  32. Trend in Japanese malpractice litigation involving gastrointestinal endoscopy, Am J Gastroenterol, 104(1), 251-252, 20090101
  33. Rapid progression of Epstein -Barr-virus-positive gastric diffuse large B-cell lymphoma during chemoradiotherapy: a case report, Clin J Gastroenterol, 1, 105-109, 20081218
  34. Genetic polymorphisms and head and neck cancer risk (Review), Int J Oncol, 32, 945-973, 20080430
  35. Strategy for treatment of nonerosive reflux disease in Asia, World J Gastroenterol, 14(20), 3123-3128, 20080724
  36. Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer, World J Gastroenterol, 13(28), 3829-3835, 20070101
  37. Involvement of Kr?ppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma, World J Gastroenterol, 13(29), 3932-3938, 20070801
  38. Lymphatic vessel density at the site of deepest penetration as a predictor of lymph node metastasis in submucosal colorectal cancer, Dis Colon Rectum, 50(1), 13-21, 20070601
  39. Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: A case-control study, Scand J Gastroenterol, 42, 760-764, 20070601
  40. Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer., World J Gastroenterol., 13(28), 3829-3835, 20070701
  41. Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia, J Gastroenterol Hepatol, 22, 304-310, 20070301
  42. Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma, WORLD JOURNAL OF GASTROENTEROLOGY, 13(29), 3932-3938, 20070807
  43. Treatment of functional dyspepsia with serotonin agonists: a meta-analysis of randomized controlled trials, J Gastroenterol Hepatol, 22, 1566-1570, 20071001
  44. Genetic polymorphisms and esophageal cancer risk, Int J Cancer, 121, 1643-1658, 20070801
  45. Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients, Oncol Rep, 16(1), 11-15, 20060501
  46. Genetic progression and divergence in superficial esophageal squamous cell carcinoma by loss of heterozygosity analysis, Oncol Rep, 16, 685-691, 20061201
  47. Defensive medicine practices among gastroenterologists in Japan, World J Gastroenterol, 12(47), 7671-7675, 20061201
  48. Lymphatic vessel density at the site of deepest penetration as a predictor of lymph node metastasis in submucosal colorectal cancer, Dis Colon Rectum, 50(1), 13-21, 20060101
  49. Nuclear and mitochondrial DNA microsatellite instability in gastrointestinal stromal tumors., Pathobiology., 73(2), 93-97, 20060901
  50. Medical malpractice litigation related to gastrointestinal endoscopy in Japan: A two-decade review of civil court cases, World J Gastroenterol, 12(42), 6857-6860, 20061201
  51. Loss of heterozygosity on chromosome 10p14-p15 in colorectal carcinoma, Pathobiology, 72, 220-224, 20050901
  52. Somatic mutations of mitochondrial DNA in digestive tract cancers., J Gastroenterol Hepatol., 20(11), 1679-1684, 20051101
  53. A combination of the Helicobacter pylori stool antigen test and urea breath test is useful for clinical evaluation of eradication therapy: a multicenter study, J Gastroenterol Hepatol, 20, 1241-1245, 20050801
  54. Characteristics and trends of clarithromycin-resistant Helicobacter pylori isolates in Japan over a decade, Pathobiology, 71, 159-163, 20040901
  55. Clinicopathologic and endoscopic features of colorectal serrated adenoma:differences between polypoid and superficial types, Gastrointest Endosc, 59(2), 213-219, 20040201
  56. Expression of human telomerase reverse transcriptase mRNA in esophageal cancers and precancerous lesions., Oncol.Rep., 11, 51-55, 20040401
  57. Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma, Int J Oncol, 24, 539-547, 20040201
  58. Chromosomal and microsatellite instability in sporadic gastric cancer, J Gastroenterol Hepatol, 19, 756-760, 20040501
  59. Clinicopathologic features and endoscopic resection of early primary nonampullary duodenal carcinoma, J Clin Gastroenterol, 37(5), 381-386, 20040501
  60. Frequent loss of heterozygosity on chromosome 10p14-p15 in esophageal dysplasia and squamous cell carcinoma, Oncol Rep, 12, 333-337, 20040401
  61. Nodular gastritis in adults is caused by Heliccobacter pylori infection., Dig Dis Sci, 48, 968-975, 20030401
  62. Frequnet loss of heterozygosity onchromosome 10p15, a putative telomerase repressor・senescence gene locus, in gastric cancer., Oncol.Rep., 10, 1297-1299, 20030401
  63. Minute depressed colon cancer with submucosal invasion., Gastrointest Endosc, 57, 564-565, 20030401
  64. Hypoxia-inducible factor-1alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach., Oncol.Rep., 10, 797-802, 20030401
  65. Somatic mutation of mitochondrial DNA in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer., Int. J. Mol. Med., 12, 169-174, 20030401
  66. Clinicopathologic features and endoscopic resection of early primary nonampullary duodenal carcinoma, J.Clin.Gastroenterol., 37(5), 381-386, 20030401
  67. p53 expression, K-ras gene mutation and microsatellite instability in gastric B-cell lymphomas, J Gastroeterol Hepatol, 18(9), 1047-1053, 20030401
  68. Somatic mutation of mitochondrial DNA in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer, Int. J. Mol. Med., 12(2), 169-174, 20030401
  69. Clinical significance of thrombospondin-1 expression in relation to vascular endothelial growth factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal carcinoma., Int J Oncol, 23, 901-911, 20030401
  70. Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types., Int. J. Mol. Med., 12, 437-442, 20030401
  71. Prevalence of Helicobacter pylori resistance to clarithromycin and metronidazole determined by 23S ribosomal RNA and rdxA gene analyses in Hiroshima, Japan., J Gastroenterol Hepatol., 18, 1202-1207, 20030401
  72. Somatic mutation in mitochondrial DNA and nuclear microsatellite instability in gastric cancer, Oncol.Rep., 10, 1837-1841, 20030401
  73. Necessity of multiple gastric biopsies from different sites for detection of clarithromycin-resistant Helicobacter pylori strains., Scand. J. Gastroenterol., 38, 942-946, 20030401
  74. High incidence of B-cell monoclonality in follicular gastritis: a possible association between follicular gastritis and MALT lymphoma., Virchows Arch., 440(4), 376-380, 20020401
  75. Human telomerase reverse transcriptase, p53 and Ki-67 expression and apoptosis in colorectal serrated adenoma., Scand. J. Gastroenterol., 37, 1194-1200, 20020401
  76. K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer., Int J Cancer, 97, 562-566, 20020401
  77. p53 codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis., Int J Cancer, 100, 304-308, 20020401
  78. B-cell monoclonality inHelicobacter pylori-associated chronic atrophic gastritis., Virchows arch, 438, 232-7, 20010401
  79. Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability., Int J Oncol, 18, 1207-12, 20010401
  80. c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma., Oncol.Rep., 8, 289-292, 20010401
  81. Microsatellite instability at D18S61 is associated with no regression of gastric mucosa-associated lymphoid tissue lymphoma after Helicobacter pylori eradication, Oncol.Rep., 8, 293-297, 20010401
  82. Clinicopathological features of gastric mucosa-associated lymphoid tissue lymphoma: A comparison with diffuse large B-cell lymphoma without a mucosa-associated lymphoid tissue lymphoma component, J Gastroen Hepatol, 16, 734-739, 20010401
  83. Microsatellite instability is a genetic marker for the development of multiple gastric cancers., Int J Cancer., 95(6), 350-353, 20011101
  84. Eradication therapy of Helicobacter pylori for low-grade mucosa-associated lymphoid tisue lymphomas of the stomach., Exp.Oncol., 22, 78-81, 20000401
  85. Alteration of p73 preferentialy occur in gastric adenocarcinomas with foveolar epithelial phenotype., Int J Cancer, 83, 192-196, 19990401
  86. Overexpression of human telomerase RNA is an early event in oesophageal carcinogenesis., Virchows arch, 434, 483-7, 19990401
  87. In situ mRNA hybridization technique for analysis of human telomerase RNA in gastric precancerous and cancerous lesions, Japanese Journal of Cancer Research, 89(11), 1187-1194, 19980401
  88. Cell proliferation in polypoid type and superficial type serrated adenomas of the colorectum., In Recent Advances in Gastroenterological Carcinogenesis= Monduzzi Editore= Bologna, I, 773-778, 19960401
  89. Asia-Pacific Colorectal Screening score: A useful tool to stratify risk for colorectal advanced neoplasms in Vietnamese patients with irritable bowel syndrome, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33(1), 150-155, 201801
  90. Abnormal Gastroesophageal Flap Valve Is Associated With High Gastresophageal Reflux Disease Questionnaire Score and the Severity of Gastroesophageal Reflux Disease in Vietnamese Patients With Upper Gastrointestinal Symptoms, JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, 24(2), 226-232, 201804
  91. Evaluation of the visibility of early gastric cancer using linked color imaging and blue laser imaging, BMC GASTROENTEROLOGY, 17, 20171208
  92. Curative Criteria After Endoscopic Resection for Superficial Esophageal Squamous Cell Carcinomas, DIGESTIVE DISEASES AND SCIENCES, 63(6), 1605-1612, 201806
  93. The Distribution of Incomplete Gastric Intestinal Metaplasia (GIM) Subtype among Biopsy Sites according to the Updated Sydney System and Its Association with GIM Extension, GASTROENTEROLOGY RESEARCH AND PRACTICE, 2018

Social Activities

History as Peer Reviews of Academic Papers

  1. 2016, Gastric Cancer
  2. 2015, Journal of Gastroenterology
  3. 2014, Journal of Gastroenterology
  4. 2013, Journal of Gastroenterology
  5. 2012, Journal of Gastroenterology
  6. 2011, Journal of Gastroenterology
  7. 2010, Journal of Gastroenterology