AYUMU NAKASHIMA

Last Updated :2019/12/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), ., Professor, Collaborative Research Laboratory
E-mail
ayumuhiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 1999/06/01, 2001/03/31, Hiroshima University, Medical Hospital, Clinical Resident
  • 2009/09/01, 2010/03/31, Karolinska Institutet, Visiting Researcher
  • 2010/04/01, 2011/03/31, Hiroshima University, Graduate School of Biomedical Sciences , Assistant Professor
  • 2011/04/01, 2013/09/19, Hiroshima University Hospital, Assistant Professor (Special Appointment)
  • 2013/09/20, 2015/03/31, Hiroshima University Hospital, Medical Center for Translational and Clinical Research, Assistant Professor (Special Appointment)
  • 2015/04/01, 2017/03/31, Hiroshima University, Research Institute for Radiation Biology and Medicine, Assistant Professor (Special Appointment)
  • 2017/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences(Medicine), Professor, Collaborative Research Laboratory

Educational Backgrounds

  • Hiroshima University, Japan, 2004/04, 2008/09
  • Yamanashi Medical University, Japan, 1993/04, 1999/03

Academic Degrees

  • Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Kidney internal medicine

Research Activities

Academic Papers

  1. microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress, PLOS ONE, 14(6), 20190614
  2. Review of the Long-term Effects of Autologous Bone-Marrow Mononuclear Cell Implantation on Clinical Outcomes in Patients with Critical Limb Ischemia, SCIENTIFIC REPORTS, 9, 20190522
  3. Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease - Post Hoc Analysis of the FMD-J Study A, CIRCULATION JOURNAL, 83(5), 1064-+, 201905
  4. Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study, JOURNAL OF HYPERTENSION, 37(5), 1083-1095, 201905
  5. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension, EUROPEAN JOURNAL OF NUTRITION, 58(3), 989-996, 201904
  6. Serum-Free Medium Enhances the Immunosuppressive and Antifibrotic Abilities of Mesenchymal Stem Cells Utilized in Experimental Renal Fibrosis, STEM CELLS TRANSLATIONAL MEDICINE, 7(12), 893-905, 201812
  7. pH after the first session of direct hemoperfusion with polymyxin B-immobilized fibers predicts mortality in patients with sepsis and septic shock, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 22(5), 1167-1173, 201810
  8. TGF-beta 1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA, SCIENTIFIC REPORTS, 8, 20180919
  9. Dec1 and CLOCK Regulate Na+/K+-ATPase 1 Subunit Expression and Blood Pressure, HYPERTENSION, 72(3), 746-754, 201809
  10. Comparing the 12-month patency of low- versus high-pressure dilation in failing arteriovenous fistulae: A prospective multicenter trial (YOROI study), JOURNAL OF VASCULAR ACCESS, 19(5), 477-483, 201809
  11. Tocilizumab histologically improved AA renal amyloidosis in a patient with multicentric Castleman disease: A case report, CLINICAL NEPHROLOGY, 90(3), 232-236, 201809
  12. Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction, PLOS ONE, 13(8), 20180816
  13. New assessment of endothelial function measured by short time flow-mediated vasodilation: Comparison with conventional flow-mediated vasodilation measurement, INTERNATIONAL JOURNAL OF CARDIOLOGY, 265, 24-29, 20180815
  14. High-normal albuminuria and incident chronic kidney disease in a male nondiabetic population, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 22(4), 835-842, 201808
  15. Na+-Cl- cotransporter-mediated chloride uptake contributes to hypertension and renal damage in aldosterone-infused rats, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 315(2), F300-F312, 201808
  16. Deficiency of the basic helix-loop-helix transcription factor DEC1 prevents obesity induced by a high-fat diet in mice, GENES TO CELLS, 23(8), 658-669, 201808
  17. Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD-J (Flow-Mediated Dilation Japan) Study A, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(14), 20180717
  18. Endothelial dysfunction, abnormal vascular structure and lower urinary tract symptoms in men and women, INTERNATIONAL JOURNAL OF CARDIOLOGY, 261, 196-203, 20180615
  19. Reactive hyperemia-peripheral arterial tonometry is useful for assessment of not only endothelial function but also stenosis of the digital artery, INTERNATIONAL JOURNAL OF CARDIOLOGY, 260, 178-183, 20180601
  20. Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis, PLOS ONE, 13(5), 20180503
  21. Mesenchymal Stem Cell-Based Therapy Improves Lower Limb Movement After Spinal Cord Ischemia in Rats, ANNALS OF THORACIC SURGERY, 105(5), 1523-1530, 201805
  22. Chronic kidney disease is associated with vascular smooth muscle dysfunction but not with endothelial dysfunction, INTERNATIONAL JOURNAL OF CARDIOLOGY, 254, 284-290, 20180301
  23. NT-proBNP is a useful biomarker to identify cardiac dysfunction in Japanese hemodialysis patients., INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 41(3), 135-143, 201803
  24. Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study, ATHEROSCLEROSIS, 268, 92-98, 201801
  25. Interrelationships between Flow-Mediated Vasodilation, Nitroglycerine-Induced Vasodilation, Baseline Brachial Artery Diameter, Hyperemic Shear Stress, and Cardiovascular Risk Factors, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(1), 201801
  26. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension., Eur J Nutr., 2018
  27. pH after the first session of direct hemoperfusion with polymyxin B-immobilized fibers predicts mortality in patients with sepsis and septic shock., Clin Exp Nephrol., 2018
  28. Tocilizumab histologically improved AA renal amyloidosis in a patient with multicentric Castleman disease: A case report., Clin Nephrol., 90(3), 232-236, 2018
  29. Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD-J (Flow-Mediated Dilation Japan) Study A., J Am Heart Assoc., 7(14), 2018
  30. Serum-free medium enhances the immunosuppressive and anti-fibrotic abilities of mesenchymal stem cells utilized in experimental renal fibrosis., Stem Cell Transl Med., 2018
  31. TGF-beta1 promotes fibrotic gene expression through the induction of histone variant H3.3 and histone chaperone HIRA., Sci Rep., 2018
  32. Valproic acid attenuates renal fibrosis through the induction of autophagy, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 21(5), 771-780, 201710
  33. Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis., PLOS ONE, 12(3), 201709
  34. Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Functuon in Statin Naive Individuals., Sci Rep, 7(1), 20170821
  35. Decreased frequency and duration of tooth brushing is a risk factor for endothelial dysfunction, INTERNATIONAL JOURNAL OF CARDIOLOGY, 241, 30-34, 20170815
  36. Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug TreatmentRegardless of Blood Pressure Level:FMD-J Study (Flow-Mediated Dilation Japan)., Hypertension, 20170814
  37. Relation of the Bilateral Earlobe Crease to Endothelial Dysfunction, AMERICAN JOURNAL OF CARDIOLOGY, 119(12), 1983-1988, 20170615
  38. Increasing Risk of Osteoporotic Fracture Is Associated With Vascular Dysfunction and Abnormal Vascular Structure in Both Men and Women, CIRCULATION JOURNAL, 81(6), 862-+, 201706
  39. Endothelial dysfunction and abnormal vascular structure are simultaneously present in patients with heart failure with preserved ejection fraction, INTERNATIONAL JOURNAL OF CARDIOLOGY, 231, 181-187, 20170315
  40. Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis, PLOS ONE, 12(3), 20170309
  41. Endothelial function is impaired in relation to alcohol intake even in the case of light alcohol consumption in Asian men; Flow-mediated Dilation Japan (FMD-J) Study, INTERNATIONAL JOURNAL OF CARDIOLOGY, 230, 523-528, 20170301
  42. Circulating level of pigment epithelium-derived factor is associated with vascular function and structure: A cross-sectional study, INTERNATIONAL JOURNAL OF CARDIOLOGY, 225, 91-95, 20161215
  43. Endothelial Function Assessed by Automatic Measurement of Enclosed Zone Flow-Mediated Vasodilation Using an Oscillometric Method Is an Independent Predictor of Cardiovascular Events, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 5(12), 201612
  44. Nitroglycerine-induced vasodilation in coronary and brachial arteries in patients with suspected coronary artery disease, INTERNATIONAL JOURNAL OF CARDIOLOGY, 219, 312-316, 20160915
  45. Linagliptin Ameliorates MethylglyoxalInduced Peritoneal Fibrosis in Mice, PLOS ONE, 11(8), 20160811
  46. Relationship between serum triglyceride levels and endothelial function in a large community-based study, ATHEROSCLEROSIS, 249, 70-75, 201606
  47. Combination of Flow-Mediated Vasodilation and Nitroglycerine-Induced Vasodilation Is More Effective for Prediction of Cardiovascular Events., HYPERTENSION, 67(5), 1045-52, 20160314
  48. High glucose promotes TGF-beta 1 production by inducing FOS expression in human peritoneal mesothelial cells, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 20(1), 30-38, 201602
  49. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27(1), 203-215, 201601
  50. Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression, KIDNEY INTERNATIONAL, 89(1), 147-157, 201601
  51. Vascular Function and Intima-media Thickness of a Leg Artery in Peripheral Artery Disease: A Comparison of Buerger Disease and Atherosclerotic Peripheral Artery Disease, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 23(11), 1261-1269, 2016
  52. Reduction in blood pressure improves impaired nitroglycerine-induced vasodilation in patients with essential hypertension, HYPERTENSION RESEARCH, 38(12), 862-868, 201512
  53. Hepatitis B virus infection in hemodialysis patients in Japan: Prevalence, incidence and occult hepatitis B virus infection, HEPATOLOGY RESEARCH, 45(12), 1211-1219, 201512
  54. Rho-Associated Kinase Activity Is an Independent Predictor of Cardiovascular Events in Acute Coronary Syndrome, HYPERTENSION, 66(4), 892-899, 201510
  55. Expression of age-related factors during the development of renal damage in patients with IgA nephropathy, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19(5), 830-837, 201510
  56. Efficacy of add-on therapy of aliskiren to an angiotensin II receptor blocker on renal outcomes in advanced-stage chronic kidney disease: a prospective, randomized, open-label study, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19(4), 631-638, 201508
  57. Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial, HYPERTENSION RESEARCH, 38(7), 485-490, 201507
  58. Effect of aldosterone-producing adenoma on endothelial function and Rho-associated kinase activity in patients with primary aldosteronism., Hypertension., 65(4), 841-8, 20150126
  59. Ratio of Serum Levels of AGEs to Soluble Form of RAGE Is a Predictor of Endothelial Function, DIABETES CARE, 38(1), 119-125, 201501
  60. The Serum Lipids Levels may be Underestimated in Patients on Hemodialysis, INTERNAL MEDICINE, 54(8), 887-894, 2015
  61. Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients, CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9(12), 2117-2122, 201412
  62. Critical Role of Exogenous Nitric Oxide in ROCK Activity in Vascular Smooth Muscle Cells, PLOS ONE, 9(10), 20141003
  63. Relationship between nitroglycerine-induced vasodilation and clinical severity of peripheral artery disease, ATHEROSCLEROSIS, 235(1), 65-70, 201407
  64. Borderline Ankle-Brachial Index Value of 0.91-0.99 Is Associated With Endothelial Dysfunction, CIRCULATION JOURNAL, 78(7), 1740-+, 201407
  65. Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 18(3), 499-506, 201406
  66. Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats, PLOS ONE, 9(4), 20140402
  67. Rho-Associated Kinase Activity Is a Predictor of Cardiovascular Outcomes, HYPERTENSION, 63(4), 856-864, 201404
  68. Poor Oral Health, That Is, Decreased Frequency of Tooth Brushing, Is Associated With Endothelial Dysfunction, CIRCULATION JOURNAL, 78(4), 950-954, 201404
  69. Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study, HEART, 99(24), 1837-1842, 20131215
  70. Different circadian expression of major matrix-related genes in various types of cartilage: modulation by light-dark conditions, JOURNAL OF BIOCHEMISTRY, 154(4), 373-381, 201310
  71. Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-beta 1 signaling, KIDNEY INTERNATIONAL, 84(2), 297-307, 201308
  72. A novel noninvasive and simple method for assessment of endothelial function: Enclosed zone flow-mediated vasodilation (ezFMD) using an oscillation amplitude measurement, ATHEROSCLEROSIS, 229(2), 324-330, 201308
  73. Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model, PLOS ONE, 8(7), 20130704
  74. Nitroglycerine-Induced Vasodilation for Assessment of Vascular Function A Comparison With Flow-Mediated Vasodilation, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(6), 1401-+, 201306
  75. Flow-Mediated Vasodilation and Anatomical Variation of the Brachial Artery (Double Brachial Artery) in Healthy Subjects and Patients With Cardiovascular Disease, CIRCULATION JOURNAL, 77(4), 1073-1080, 201304
  76. Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women, BMJ OPEN, 3(11), 2013
  77. Morning blood pressure is useful for detection of left ventricular hypertrophy in hemodialysis patients, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 16(6), 921-929, 201212
  78. Intima-Media Thickness of Brachial Artery, Vascular Function, and Cardiovascular Risk Factors, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(9), 2295-+, 201209
  79. Hyperbilirubinemia, Augmentation of Endothelial Function, and Decrease in Oxidative Stress in Gilbert Syndrome, CIRCULATION, 126(5), 598-603, 20120731
  80. Regulation of basic helix-loop-helix transcription factors Dec1 and Dec2 by RORa and their roles in adipogenesis, GENES TO CELLS, 17(2), 109-121, 201202
  81. Endogenous estrogen may prevent bone loss in postmenopausal hemodialysis patients throughout life, OSTEOPOROSIS INTERNATIONAL, 22(5), 1573-1579, 201105
  82. Total Numbers of Undiagnosed Carriers of Hepatitis C and B Viruses in Japan Estimated by Age- and Area-Specific Prevalence on the National Scale, INTERVIROLOGY, 54(4), 185-195, 2011
  83. Protein-energy wasting modifies the association of ghrelin with inflammation, leptin, and mortality in hemodialysis patients., Kidney Int79, 79(7), 749-56, 20101222
  84. Association of Nodular Hyperplasia With Resistance to Cinacalcet Therapy for Secondary Hyperparathyroidism in Hemodialysis Patients, THERAPEUTIC APHERESIS AND DIALYSIS, 14(6), 577-582, 201012
  85. Postprandial metabolic response to a fat- and carbohydrate-rich meal in patients with chronic kidney disease., Nephrol Dial Transplant., 26(7), 2231-7, 20101123
  86. Effect of circulating soluble receptor for advanced glycation end products (sRAGE) and the proinflammatory RAGE ligand (EN-RAGE, S100A12) on mortality in hemodialysis patients., CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 5(12), 2213-9, 20100916
  87. Vitamin K2 alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level., Nephron Clin Pract, 117(1), C15-19, 20100801
  88. Dose conversion ratio one year after switching from epoetin alpha to darbepoetin alpha in Japanese hemodialysis patients, INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 33(5), 283-289, 201005
  89. Plasma osteoprotegerin, arterial stiffness, and mortality in normoalbuminemic Japanese hemodialysis patients., Osteoporos Int., 22(6), 1695-701, 201002
  90. Switching from epoetin alpha to darbepoetin alpha in Japanese hemodialysis patients: dose conversion ratio, Nephron Clin Pract, 111(2), c81-6, 20091217
  91. Response of secondary hyperparathyroidism to cinacalcet depends on parathyroid size., Nephron Clin Pract, 114(3), c187-93, 20091128
  92. Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model., Nephron Exp Nephrol, 112(2), e59-69, 20090423
  93. C-C chemokine receptor 2 expression by circulating monocytes influences atherosclerosis in patients on chronic hemodialysis., Ther Apher Dial, 13(3), 205-12, 2009
  94. Liver X receptors (LXRalpha and LXRbeta) are potent regulators for hepatic Dec1 expression, Genes Cells, 14(1), 29-40, 20081121
  95. DEC1 modulates the circadian phase of clock gene expression, Mol Cell Biol., 28(12), 4080-92, 20080414
  96. Protective effects of peroxisome proliferator-activated receptor gamma ligand on apoptosis and hepatocyte growth factor induction in renal ischemia-reperfusion injury., Transplantation, 84(2), 207-13, 20070727
  97. Effects of fasting and re-feeding on the expression of Dec1, Per1, and other clock-related genes, JOURNAL OF BIOCHEMISTRY, 140(3), 401-408, 200609
  98. Osteoprotegerin and bone mineral density in hemodialysis patients., Osteoporos Int, 17(6), 841-6, 200607
  99. Decreased total and high molecular weight adiponectin are independent risk factors for the development of type 2 diabetes in Japanese-Americans., J Clin Endocrinol Metab, 91(10), 3873-7, 200601
  100. Performance of polysulfone membrane dialyzers and dialysate flow pattern, Clin Exp Nephrol, 10(3), 210-5, 2006
  101. Serum cross-linked N-terminal telopeptide of type I collagen for evaluation of renal osteodystrophy in hemodialysis patients., Nephron Clin Pract., 99(3), c78-85, 20050119
  102. HMG-CoA reductase inhibitors prevent bone loss in patients with Type 2 diabetes mellitus, Diabet Med, 21(9), 1020-4, 2004
  103. Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels, Bone, 34(3), 579-83, 2004
  104. Bone mineral density may be related to atherosclerosis in hemodialysis patients, Osteoporos Int, 14(5), 369-73, 20030324
  105. Different risk factors for the maximum and the mean carotid intima-media thickness in hemodialysis patients., Intern Med, 42(11), 1095-9, 2003
  106. Radial bone mineral density in hemodialysis patients with adynamic bone disease, Int J Artif Organs, 26(3), 200-4, 2003
  107. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study, SCIENTIFIC REPORTS, 9, 20190715
  108. Relationship between home blood pressure and vascular function in patients receiving antihypertensive drug treatment, HYPERTENSION RESEARCH, 42(8), 1175-1185, 201908

Publications such as books

  1. Heart View, 2012

Invited Lecture, Oral Presentation, Poster Presentation

  1. Stem cell research in PD, Ayumu Nakashima, International society of peritoneal dialysis, 2015/11, With Invitation
  2. Relationships between Nitroglycerine-induced Vasodilation in the Brachial Artery and Cardiovascular Risk Factors., Tatsuya Maruhashi, Nozomu Oda, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Yumiko Iwamoto, Takayuki Hidaka, Ayumu Nakashima, Kensuke Noma, Yasuki Kihara, Yukihito Higashi., The 11th Pulse of Asia 2014, 2014/06, Without Invitation, Athens
  3. Impact of Aldosterone Producing Adenoma on Endothelial Function in Patients With Primary Aldosteronism., Takeshi Matsumoto, Nozomu Oda, Akimichi Iwamoto, Yumiko Iwamoto, Masato Kajikawa, Tatsuya Maruhashi, Takayuki Hidaka, Ayumu Nakashima, Kensuke Noma, Yasuki Kihara, Yukihito Higashi., The 11th Pulse of Asia, 2014/06, Without Invitation, Athena, Greece.
  4. Combination of Flow-mediated Vasodilation and Nitroglycerine-induced Vasodilation for Prediction of Cardiovascular Events., Masato Kajikawa, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi iwamoto, Takeshi Matsumoto, Takayuki Hidaka, Ayumu Nakashima, Kensuke Noma, Yasuki Kihara, Yukihito Higashi., The 11th Pluse of Asia, 2014/06, Without Invitation, Athens
  5. A Comparison of Nitroglycerine-induced Vasodilation with Flow-mediated Vasodilation as a Cardiovascular Risk Marker., Tatsuya Maruhashi, Nozomu Oda, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Yumiko Iwamoto, Takayuki Hidaka, Ayumu Nakashima, Kensuke Noma, Yasuki Kihara, Yukihito Higashi., European Society of Cardiology Congress 2014, 2014/08, Without Invitation, Barcelona
  6. Endothelial Function Is Impaired in Subjects with Decreased Frequency of Tooth Brushing., Masato Kajikawa, Yukihito Higashi, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi iwamoto, Takeshi Matsumoto, Nozomu Oda, Takayuki Hidaka, Ayumu Nakashima, Kensuke Noma, Yasuki Kihara., 87th Scientific Sessions, American Heart Association, 2014/11, Without Invitation, Chicago, IL.
  7. Prognostic Value of Combination of Flow-mediated Vasodilation and Nitroglycerine-induced Vasodilation., Masato Kajikawa, Yukihito Higashi, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi iwamoto, Takeshi Matsumoto, Nozomu Oda, Takayuki Hidaka, Ayumu Nakashima, Kensuke Noma, Yasuki Kihara., 87th Scientific Sessions, American Heart Association, 2014/11, Without Invitation, Chicago, IL.
  8. Endothelial Function Is Impaired in Peripheral Arterial Disease with Borderline Ankle-Brachial Index., Masato Kajikawa, Yukihito Higashi, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi iwamoto, Takeshi Matsumoto, Nozomu Oda, Takayuki Hidaka, Ayumu Nakashima, Kensuke Noma, Yasuki Kihara., 87th Scientific Sessions, American Heart Association, 2014/11, Without Invitation, Chicago, IL.
  9. Nitroglycerine-induced Vasodilation was Significantly Impaired in Peripheral Artery Disease-patients with Critical Limb Ischemia Compared with Those without., Tatsuya Maruhashi, Yukihito Higashi, Nozomu Oda, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Yumiko Iwamoto, Ayumu Nakashima, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara., 87th Scientific Sessions, American Heart Association, 2014/11, Without Invitation, Chicago, IL.
  10. Nitroglycerine-induced Vasodilation in the Brachial Artery and Cardiovascular Risk Factors., Tatsuya Maruhashi, Yukihito Higashi, Nozomu Oda, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Yumiko Iwamoto, Ayumu Nakashima, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara., 2014/03, Without Invitation
  11. Difference Between Nitroglycerine-induced Vasodilation and Flow-mediated Vasodilation in Association with the Severity of Atherosclerosis., Tatsuya Maruhashi, Yukihito Higashi, Nozomu Oda, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Yumiko Iwamoto, Ayumu Nakashima, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara., 2014/03, Without Invitation
  12. Poor Oral Health Behavior is Associated with Endothelial Dysfunction., Masato Kajikawa, Yukihito Higashi, Kensuke Noma, Takayuki Hidaka, Ayumu Nakashima, Shinsuke Mikami, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi Iwamoto, Yasuki Kihara., 2014/03, Without Invitation
  13. Rho-Associated Kinase Activity and Risk of Cardiovascular Events., Masato Kajikawa, Yukihito Higashi, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi iwamoto, Takeshi Matsumoto, Takayuki Hidaka, Ayumu Nakashima, James K. Liao, Kensuke Noma, Yasuki Kihara., 2014/03, Without Invitation
  14. The association between estimated glomerular filtration rate and endothelial function in 3,523 Japanese subjects: FMD-J registry, Ayumu Nakashima, Tatsuya Maruhash, Masato Kajikawa, Takeshi Matsumoto, Takayuki Hidaka, Akimichi Iwamoto, Yumiko Iwamoto, Kensuke Noma, Hirofumi Tomiyama, Bonpei Takase, Akira Yamashina, Yukihito Higashi, The 11th Pulse of Asia, 2014/06, Without Invitation, Athena, Greece.
  15. Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression., Irifuku T, Doi S, Sasaki K, Nakashima A, Masaki T., Amrican society of Nephrology, 2014/11, Without Invitation, San Diego, USA
  16. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis., Sasaki K, Nakashima A, Doi S, Masaki T., American Society of Nephrology, 2014/11, Without Invitation, San Diego, USA
  17. A Significant Correlation Between Nitroglycerine-induced Vasodilation in Coronary and Brachial Arteries, Tatsuya Maruhashi, Yukihito Higashi, Masato Kajikawa, Ayumu Nakasima, Yumiko Iwamoto, Akimiti Iwamoto, Nozomu Oda, Shinji Kisimoto, Shogo Matsui, Tadanao Higaki, Takasi Shimonaga, Noriaki Watanabe, Hiroki Ikenaga, Takayuki Hidaka, Yoshiki Aibara, Kensuke Noma, Yasuki Kihara., 2016/11/13, Without Invitation, New Orleans
  18. Light to Moderate Alcohol Consumption Does Not Alter Endothelial Function., Nozomu Oda, Yukihito Higashi, Masato Kajikawa, Tatsuya Maruhasi, Shinji Kishimoto, Shogo Matsui, Takayuki Hidaka, Ayumu Nakashima, Kensuke Noma, Hirofumi Tomiyma, Bonpei Takase, Akira Yamashina, Yasuki Kihara., 2016/11/15, Without Invitation, New Orleans
  19. Vascular Smooth Muscle function in Coronary and Brachial Arteries in Patients with Suspected Coronary Artery Disease, Tatsuya Maruhashi, Masato Kajikawa, Ayumu Nakasima, Yumiko Iwamoto, Akimichi Iwamoto, Nozomu Oda, Shinji Kishimoto, Syogo Matsui, Kensuke Noma,Yasuki Kihara, Yukihiko Higashi, The Pulse of Asia 2016, 2016/09/24, Without Invitation, Seoul
  20. Vascular Function and Rho-associated Kinase Activity in Patients with Idiopathic hyperaldosteronism, Shinji Kishimoto, Takeshi Matsumoto, Syogo Matsui, Nozomu Oda, Masato Kajikawa, Yumiko Iwamoto, Tatsuya Maruhasi, Ayumu Nakashima, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara, Yukihiko Higashi., Pulse of Asia 2016, 2016/09/25, Without Invitation, Seoul
  21. Impact of Triglycerides as Residual Risk for Cardiovascular Events on Endothelial Function:FMD-Japan Registry, Masato Kajikawa, Tatsuya Maruhashi, Nozomu Oda, Shinji kishimoto, Syogo Matsui, Takayuki Hidaka, Yasuki kihara, Kensuke Noma, Ayumu Nakashima, Hirofumi Tomiyama, Bonpei Takase, Akira Yamashina, Yukihito Higashi, The Pulse of Asia 2016, 2016/09/25, Without Invitation, Seoul,Korea
  22. Endothelial Function Is Impaired in Subjects with Decreased Frequency and Duration of Tooth Brushing., Syogo Matsui, Yukihito Higashi, Masato Kajikawa, Tatsuya Maruhashi, Akimichi Iwamoto, Nozomu Oda, Shinji Kishimoto, Takayuki Hidaka, Ayumu Nakashima, Kensuke Noma, Yasuki Kihara., The Pulse of Asia, 2016/09/25, Without Invitation, Seoul,Korea
  23. Vascular Function and Vascular Structure are Impaired in Patients with Heart Failure with Preserved Ejection Fraction, Shinji Kishimoto, Yukihito Higashi, Nozomu Oda, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Yumiko Iwamoto, Tatsuya Maruhashi, Ayumu Nakashima, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara., 2016/03/18, Without Invitation
  24. Endothelial Function is impaired in Subjects with Increased Serum Triglyceride Levels, Masato Kajikawa, Yukihito Higashi, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi Iwamoto, Nozomu Oda, Shinji Kishimoto, Takayuki Hidaka, Ayumu Nakashima, Kensuke Noma, Hirofumi Tomiyama, Bonpei Takase, Akira Yamashina, Yasuki Kihara, 2016/03/19, Without Invitation
  25. High-normal albuminuria predicts the incidence of chronic kidney disease in a nondiabetic population, Aki Sanada, Toshinori Ueno,Ayumu Nakashima,Shigehiro Doi,Kiminori Yamane,Takao Masaki, American Society of Nephrology2016, 2016/11/15, Without Invitation
  26. Stem cell research in PD, The 8th Asia Pacific Chapter Meeting of International Society for Peritoneal Dialysis, 2017/03/22, With Invitation
  27. Mesenchymal stem cells cultured in serum-free medium ameliorate experimental renal fibrosis by their strong immunosuppressive effects, Ken Yoshida, Ayumu Nakashima, Shigehiro Doi, Toshinori Ueno, Yukio Kato, Yukihito Higashi, Takao Masaki, American Society of Nephrology 2016, 2017/10/31, Without Invitation
  28. Prognostic Factors in sepsis patients who have undergone direct hemoperfusion with polymyxin b-immobilized fibers, Aiko Okubo, Ayumu Nakashima, Shigehiro Doi, Toshihiro Ueno, Takao Masaki, American Society of Nephrology 2016, 2017/10/31, Without Invitation
  29. MicroRNA-200c is involved in Klotho reduction by oxidative stress in human tubular cells, Kenichi Morii, Satoshi Yamasaki, Shigehiro Doi, Kensuke Sasaki, Toshinori Ueno, Ayumu Nakashima, Takao Masaki, Kenichi Morii, Satoshi Yamasaki, Shigehiro Doi, Kensuke Sasaki, Toshinori Ueno, Ayumu Nakashima, Takao Masaki, American Society of Nephrology 2016, 2017/10/31, Without Invitation
  30. TGF-Beta1 promotes fibrotic gene expression through induction of histone variant H3.3 and histone chaperone HIRA, Toshihiro Shindo, Shigehiro Doi, Kensuke Sasaki, Ayumu Nakashima, Takao Masaki, American Society of Nephrology 2016, 2017/10/31, Without Invitation
  31. Mesenchymal stem cells cultured in serum-free medium ameliorate experimental renal fibrosis by their strong immunosuppressive effects, Ken Yoshida, Ayumu Nakashima, Shigehiro Doi, Toshinori Ueno, Yukio Kato, Yukihito Higashi, Takao Masaki, ISN FRONTIERS MEETINGS 2018, 2018/02/22, Without Invitation
  32. Prognostic Factors in sepsis patients who have undergone direct hemoperfusion with polymyxin b-immobilized fibers, Aiko Okubo, Ayumu Nakashima, Shigehiro Doi, Toshihiro Ueno, Takao Masaki, ISN FRONTIERS MEETINGS 2018, 2018/02/22, Without Invitation
  33. MicroRNA-200c is involved in Klotho reduction by oxidative stress in human tubular cells, Kenichi Morii, Satoshi Yamasaki, Shigehiro Doi, Kensuke Sasaki, Toshinori Ueno, Ayumu Nakashima, Takao Masaki, ISN FRONTIERS MEETINGS 2018, 2018/02/22, Without Invitation
  34. TGF-Beta1 promotes fibrotic gene expression through induction of histone variant H3.3 and histone chaperone HIRA, Toshihiro Shindo, Shigehiro Doi, Kensuke Sasaki, Ayumu Nakashima, Takao Masaki, ISN FRONTIERS MEETINGS 2018, 2018/02/22, Without Invitation
  35. Klotho Overexpression Improves Interstitial Fibrosis,Accumulation of Cell CycleArrested Cells,and Increased Levels of Oxidative Stress in the Kidneys of Aging Mice, Ohishi H, Ohishi H,Doi S,Nakashima A,Masaki T, American Society of Nephrology2018, 2018/10/23, Without Invitation, San Diego
  36. Inhibition of H3K4 Trimethylation Attenuates Renal Senescence in Mice with Ischemic Reperfusion Injury, Shimoda H, Shimoda H,Doi S,Nakashima A,Masaki T, American Society of Nephrology 2018, 2018/10/23, Without Invitation, San Diego
  37. Deubiquitinase Inhibitor PR-619 Reduces Smad4 Expression and Suppresses Renal Fibrosis in Mice with Unilateral Ureteral Obstruction, Soji K, Soji K,Doi S,Nakashima A,Masaki T, American Society of Nephrology2018, 2018/10/23, Without Invitation, San Diego
  38. Mesenchymal stem cells cultured in serum-free medium ameliorate experimental peritoneal fibro- sis, Ryo Tamura, Ryo Tamura ,Ayumu Nakashima ,Kohei Nagasaki ,Toshinori Ueno ,Naoki Ishiuchi ,Toshiki Doi ,Shigehiro Doi ,Yukio Kato ,Takao Masaki, APCM-ISPD 2019, 2019/09/05, Without Invitation
  39. A comparison of mortality and cardiovascular disease between patients with peritoneal dialysis and those with hemodialysis: Retrospective cohort study in Hiroshima, Kazuya Maeda, Kazuya Maeda,Shigehiro Doi ,Ayumu Nakashima,Toshiki Doi,Shuma Hirashio,Takao Masaki, APCM-ISPD, 2019/09/05, Without Invitation
  40. High-Normal Albuminuria Is Strongly Associated with Incident CKD in a Nondiabetic Population with Normal Kidney Function, Okubo Aiko, Nakashima Ayumu, Doi Shigehiro, Doi Toshiki, Ueno Toshinori, Maeda Kazuya, Masaki Takao, Okubo Aiko, Nakashima Ayumu, Doi Shigehiro, Doi Toshiki, Ueno Toshinori, Maeda Kazuya, Masaki Takao, American Society of Nephrology Kidney Week 2019, 2019/11/07, Without Invitation, Washington DC, USA
  41. Continuous Renal Replacement Therapy with AN69ST Membrane Reduces Plasma IL-8 in Sepsis Patients, Takahashi Shunsuke, Nakashima Ayumu Handa Yuki, Kyoda Naoko, Arima Takahiro, Masaki Takao, American Society of Nephrology Kidney Week 2019, 2019/11/07, Without Invitation, Washington DC, USA
  42. Mesenchymal Stem Cells Cultured in IFN-γ-Containing Medium Ameliorate Experimental Renal Fibrosis, Kanai Ryo, Nakashima Ayumu, Doi Shigehiro, Ishiuchi Naoki, Doi Toshiki, Masaki Takao, American Society of Nephrology Kidney Week 2019, 2019/11/07, Without Invitation, Washington DC, USA
  43. Hypoxia-Preconditioned Mesenchymal Stem Cells Prevent AKI to CKD, Ishiuchi, Naoki, Nakashima Ayumu, Doi Shigehiro, Kanai Ryo Doi Toshiki, Masaki Takao, American Society of Nephrology Kidney Week 2019, 2191/10, Without Invitation, Washington DC, USA

Patented

  1. Patent
  2. Patent

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2013, 2015
  2. KAKENHI, Epidemiological study for assciation of hepatitis viral infection with mortality in patients on chronic hemodialysis, 2011, 2013
  3. KAKENHI, Clock genes regulate circadian variation of blood pressure via Na-K-ATPase, 2009, 2010
  4. KAKENHI, Effect of mesenchymal stem cell on peritoneal fibrosis in rat model, 2007, 2008
  5. KAKENHI, 2013, 2015
  6. 2014, 2016
  7. KAKENHI, 2016, 2018
  8. KAKENHI, 2017, 2020
  9. KAKENHI, 2016, 2019