Ikuo Miura

Last Updated :2018/11/01

Affiliations, Positions
Institute for Amphibian Biology, Institute for Amphibian Biology, Associate Professor
E-mail
imiurahiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2016/05/01, 2019/04/30, University of Canberra, Adjunct Associate Professor
  • 2013/02/14, 2016/02/13, University of Canberra, Adjunct Associate Professor
  • 2004/11, 2005/05, Australian National University, Visiting fellow
  • 2004/01/01, 2007/03/31, Hiroshima University, Graduate School of Science, Institute for Amphibian Biology, Associate Professor
  • 2000/04/01, 2003/12/31, Hiroshima University, Graduate School of Science, Institute for Amphibian Biology, Lecturer
  • 1997/10/01, 2000/03/31, Hiroshima University, Faculty of Science, Institute for Amphibian Biology, Lecturer
  • 1989/11/01, 1997/09/30, Hiroshima University, Faculty of Science, Institute for Amphibian Biology, Research Associate
  • 1984/06/15, 1989/10/31, Hiroshima University, Faculty of Science, Institute for Amphibian Biology

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Natural Science, Department of Zoology, Japan, 1983/04, 1984/06
  • Hiroshima University, Graduate School, Division of Natural Science, Japan, 1981/04, 1983/03
  • Hirosaki University, Faculty of Science, Japan, 1977/04, 1981/03

Academic Degrees

  • Doctor of Science, Hiroshima University
  • Master of Science, Hiroshima University

Research Fields

  • Biology;Basic biology;Evolutionary biology

Research Keywords

  • Species
  • Evolution
  • Amphibia
  • Sex chromosome
  • Sex determining mechanism
  • Reproductive isolation

Affiliated Academic Societies

  • The society of chromosome research
  • The society of evolutionary studies, Japan
  • The zoological society of Japan
  • The genetics society of Japan
  • Japan Society of Endocrine Disrupters Research,
  • The herpetological society of Japan
  • International Cytogenetics and Genome Society
  • Nippon Batrachological Society

Educational Activity

Course in Charge

  1. 2018, Liberal Arts Education Program1, 3Term, Life System through Frog Research
  2. 2018, Undergraduate Education, 2Term, Introduction to Biological Sciences A
  3. 2018, Undergraduate Education, 2Term, Advanced Biology
  4. 2018, Undergraduate Education, First Semester, Special Study for Graduation
  5. 2018, Undergraduate Education, Second Semester, Special Study for Graduation
  6. 2018, Undergraduate Education, Second Semester, Seminar for amphibian biology
  7. 2018, Undergraduate Education, Second Semester, Practice for Fundamental Biology II
  8. 2018, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  9. 2018, Graduate Education (Master's Program) , First Semester, Special Research for Thesis
  10. 2018, Graduate Education (Master's Program) , Second Semester, Special Research for Thesis
  11. 2018, Graduate Education (Master's Program) , First Semester, Brain storming seminar for biology
  12. 2018, Graduate Education (Master's Program) , First Semester, Origins of sex
  13. 2018, Graduate Education (Master's Program) , First Semester, Seminar for Evolutionary Biology and Biodiversity of Amphibians
  14. 2018, Graduate Education (Master's Program) , Second Semester, Seminar for Evolutionary Biology and Biodiversity of Amphibians
  15. 2018, Graduate Education (Doctoral Program) , First Semester, Seminar for Evolutionary Biology and Biodiversity of Amphibians
  16. 2018, Graduate Education (Doctoral Program) , Second Semester, Seminar for Evolutionary Biology and Biodiversity of Amphibians

Research Activities

Academic Papers

  1. A rapid rate of sex-chromosome turnover and non-random transitions in true frogs, Nature communications, 9(1), 4088, 2018
  2. Reconstruction of female heterogamety from admixture of XX-XY and ZZ-ZW sex chromosome systems within a frog species, MOLECULAR ECOLOGY, 2018
  3. Anomalies in the Coloration of Japanese Amphibians and Their Applications in Genetic Research., KnE Life Sciences, 97-107
  4. The Distributions and Boundary of Two Distinct, Local Forms of Japanese Pond Frog, Pelophylax porosus brevipodus, Inferred From Sequences of Mitochondrial DNA, FRONTIERS IN GENETICS, 9, APR 5 2018
  5. Sex Determination and Sex Chromosomes in Amphibia, SEXUAL DEVELOPMENT, 11(5-6), 298-306, 2017
  6. Spontaneous tyrosinase mutations identified in albinos of three wild frog species, GENES & GENETIC SYSTEMS, 92(4), 189-196, AUG 2017
  7. Evolutionary Changes in Sensitivity to Hormonally Induced Gonadal Sex Reversal in a Frog Species, SEXUAL DEVELOPMENT, 10(2), 79-90, 2016
  8. Phylogeography reveals an ancient cryptic radiation in East-Asian tree frogs (Hyla japonica group) and complex relationships between continental and island lineages, BMC EVOLUTIONARY BIOLOGY, 16, NOV 23 2016
  9. Meiotic recombination counteracts male-biased mutation (male-driven evolution), PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 283(1823), JAN 27 2016
  10. Chromosomal distribution patterns of global 5mC and 5hmC on the ZZ/ZW and XX/XY chromosomes in the Japanese wrinkled frog, Rana rugosa, induced by Tet methylcytosine dioxygenase enzymes, Chromosome Science, 18, 3-8, 2015
  11. Unusual sex ratios and developmental mortality in the rice frog Fejervarya kawamurai, Chromosome Science, in press, 2015
  12. Change of heterogametic sex from male to female: Why so easy in the frog?, Chromosome Science, 16, 3-9, 2015
  13. The evolution of mitochondrial genomes in modern frogs (Neobatrachia): nonadaptive evolution of mitochondrial genome reorganization, BMC GENOMICS, 15, AUG 20 2014
  14. Independent degeneration of W and Y sex chromosomes in frog Rana rugosa, CHROMOSOME RESEARCH, 20(1), 47-55, JAN 2012
  15. The Postzygotic Isolation of a Unique Morphotype of Frog Rana rugosa (Ranidae) Found on Sado Island, Japan, JOURNAL OF HERPETOLOGY, 46(3), 325-330, SEP 2012
  16. A new frog species of the genus Rugosa from Sado Island, Japan (Anura, Ranidae), ZOOTAXA, 49-62, DEC 7 2012
  17. Evidence for True Fall-mating in Japanese Newt Cynops pyrrhogaster, ZOOLOGICAL SCIENCE, 28(10), 758-763, OCT 2011
  18. An X-Linked Body Color Gene of the Frog Rana rugosa and Its Application to the Molecular Analysis of Gonadal Sex Differentiation, SEXUAL DEVELOPMENT, 5(5), 250-258, 2011
  19. Phyletic diversity in the frog Rana rugosa (Anura: Ranidae) with special reference to a unique morphotype found from Sado Island, Japan, Current Herpetology, 29, 69-78, 2010
  20. The ZZ/ZW sex-determining mechanism originated twice and independently during evolution of the frog, Rana rugosa, HEREDITY, 100(1), 92-99, JAN 2008
  21. Disentangling genetic vs. environmental causes of sex determination in the common frog, Rana temporaria, BMC Genetics, 9(1), 1-5, 2008
  22. Comparative chromosome mapping of sex-linked genes and identification of sex chromosomal rearrangements in the Japanese wrinkled frog (Rana rugosa, Ranidae) with ZW and XY sex chromosome systems, CHROMOSOME RESEARCH, 16(4), 637-647, JUN 2008
  23. An evolutionary witness: the frog Rana rugosa underwent change of heterogametic sex from XY male to ZW female, SEXUAL DEVELOPMENT, 1(6), 323-331, 2007
  24. An XX/XY sex microchromosome system in a freshwater turtle, Chelodina longicollis (Testudines : Chelidae) with genetic sex determination, CHROMOSOME RESEARCH, 14(2), 139-150, MAR 2006
  25. The dragon lizard Pogona vitticeps has ZZ/ZW micro-sex chromosomes, CHROMOSOME RESEARCH, 13(8), 763-776, DEC 2005
  26. Role of aromatase and androgen receptor expression in gonadal sex differentiation of ZW/ZZ-type frogs, Rana rugosa, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 134(2), 215-225, FEB 2003
  27. Change of the heterogametic sex from male to female in the frog, GENETICS, 164(2), 613-620, JUN 2003
  28. The prototype of sex chromosomes found in Korean populations of Rana rugosa, CYTOGENETIC AND GENOME RESEARCH, 99(1-4), 185-193, 2002
  29. The yellow mutation in the frog Rana rugosa: Pigment organelle deformities in the three types of chromatophore, PIGMENT CELL RESEARCH, 14(4), 283-288, AUG 2001
  30. Effects of styrene monomer and trimer on gonadal sex differentiation of genetic males of the frog Rana rugosa, ENVIRONMENTAL RESEARCH, 87(3), 175-180, DEC 2001
  31. Alteration of the sex determining system resulting from structural change of the sex chromosomes in the frog Rana rugosa, JOURNAL OF EXPERIMENTAL ZOOLOGY, 286(3), 313-319, FEB 15 2000
  32. Two isoforms of FTZ-F1 messenger RNA: molecular cloning and their expression in the frog testis, GENE, 248(1-2), 203-212, MAY 2 2000
  33. Maternal control of sex ratio in Rana rugosa: evidence from DNA sexing, MOLECULAR ECOLOGY, 9(11), 1711-1715, NOV 2000
  34. Effects of dibutyl phthalate as an environmental endocrine disrupter on gonadal sex differentiation of genetic males of the frog Rana rugosa, ENVIRONMENTAL HEALTH PERSPECTIVES, 108(12), 1189-1193, DEC 2000
  35. The erythrophore in the larval and adult dorsal skin of the brown frog, Rana ornativentri, Pigment Cell Research, 11(6), 345-354, 19981201
  36. The origin and differentiation of the heteromorphic sex chromosomes Z, W, X and Y in the frog Rana rugosa, inferred from the sequences of a sex-linked gene, ADP/ATP translocase., Molecular Biology and Evolution, 15(12), 1612-1619, 19981201
  37. Molecular cloning and expression of the SF-1/Ad4BP gene in the frog, Rana rugosa, Gene, 222, 169-176, 19980401
  38. Stage-dependent distribution of calreticulin in oocytes of the frog, Rana rugosa, Zoological Science, 14(6), 935-940, 19970401
  39. Amphidiploidy recovers the viability of hybrids between the European and Far Eastern., Journal of Experimental Zoology, 279(2), 113-117, 19971001
  40. Fluorescence replication banding of frog chromosomes., Cellular and Molecular Life Sciences, 53(1), 73-77, 19970101
  41. Molecular cloning of cDNA for the zeta isoform of the 14-3-3 protei, Zoological Science, 14(5), 771-775, 19971001
  42. Evidence for two successive pericentric inversions in sex lampbrush chromosomes of Rana rugosa (Anura: Ranidae), Chromosoma, 106, 178-182, 19970401
  43. Molecular cloning and expression of the KIF3A gene in the frog brain and testis, Zoological Science, 14, 917-921, 19970401
  44. Structural differences between XX and ZW sex lampbrush chromosomes in Rana rugosa females (Anura: Ranidae), Chromosoma, 105(4), 237-241, 19960401
  45. The late replication banding patterns of chromosomes are highly conserved in the genera Rana, Hyla, and Bufo, Chromosoma, 103(8), 567-574, 19950401
  46. The origin of the brown frogs with 2n=24 chromosomes, Experientia, 51, 179-188, 19950401
  47. Two differentiated groups of the Japanese toad, Bufo japonicus japonicus, demonstrated by C-banding analysis of chromosomes, Caryologia, 48, 123-136, 19950401
  48. Analysis of the tyrosinase gene of the Japanese pond frog, Rana nigromaculat, The Japanese Journal of Genetics, 70(1), 79-92, 19950401
  49. Melanosome formation in cultured amelanotic melanophores of Rana brevipoda by a frog tyrosinase cDNA transfection, Pigment Cell Research, 8(4), 187-193, 19950401
  50. Sex chromosome differentiation in the Japanese brown frog, Rana japonica I. Sex-related heteromorphism of the distribution pattern of constitutive heterochromatin in chromosome No.4 of the Wakuya population, Zoological Science, 11, 797-806, 19940401
  51. Sex chromosome differentiation in the Japanese brown frog, Rana japonica II. Sex-linkage analyses of the nucleolar organizer regions in chromosomes No.4 of the Hiroshima and Saeki populations, Zoological Science, 11, 807-815, 19940401
  52. Four kinds of sex chromosomes in Rana rugosa, Scientific Report of the Laboratory for Amphibian Biology= Hiroshima University, 13, 1-34, 19940401
  53. Sex chromosomes of Rana rugosa with special reference to local differences in sex determining mechanism, Scientific Report of the Laboratory for Amphibian Biology= Hiroshima University, 12, 55-81, 19930401
  54. Cloning and sequencing of the cDNA encoding tyrosinase of the Japanese pond frog, Rana nigromaculata, Gene, 121, 359-363, 19920401

Publications such as books

  1. DNA music of humans and giant salamander. In Dialogue of science and religion, Collection of materials of scientific and apologetic seminar (Yekaterinburg, 2013-2018), Parish of the Cathedral of Vic., 2018, Russian and English, Miura, Ikuo, ISBN 978-5-9907351-4-9, 95-116
  2. Sex chromosomes; Genetics, abnormalities and disorders, The W chromosome evolution and sex-linked gene expression in the Japanese frog Rana rugosa, Sex chromosome, Nova Science Publishers Inc, 2009, English, Miura I, Ezaz T, Ohtani H, Uno Y, Nishida C, Matsuda Y, and Graves JAM
  3. Advances in chromosome sciences vol.3, Molecular characterization of ZW sex chromosomes and the prototype chromosome in the frog Rana rugosa, 2009, English, Miura I, Ezaz T, Ohtani H, and Graves JAM.
  4. Sex determination, sex differentiation and maturation in amphibians, Growth, Maturation and Sex determination, Shokabo, 2016

Invited Lecture, Oral Presentation, Poster Presentation

  1. Reconstruction of female heterogametic sex determination from admixing of female and male heterogametic systems in a frog, Miura, Ikuo, Ogata M, Lambert M and Ezaz T, 6th Asian Pacific Chromosome Colloquim (APCC6), 2018/07/05, With Invitation, University of Canberra, Canberra
  2. Evolutionary reasons why a sex determining gene turnovers, Miura I, Ogata M, Ezaz T, Workshop “Cytogenetics in the genomic era”, 2017, With Invitation, Canberra, Australia
  3. Anomalies in coloration of Japanese amphibians and its application to genetic research, Miura I, The 2nd international conference “Amphibian and reptiles anomalies and pathology: methodology, evolutionary significance, monitoring and environmental health”, 2016, With Invitation, Ekaterinburg, Russia
  4. Application of genetic resources of Japanese frogs to the studies on evolution of sex determination and sex chromosome, Miura I, The 2nd international conference “Amphibian and reptiles anomalies and pathology: methodology, evolutionary significance, monitoring and environmental health, 2016, With Invitation, Ekaterinburg, Russia
  5. A double sex-determining gene in the frog Glandirana rugosa, Ikuo Miura, The 5th Asian Chromosome Colloquium, 2015/05/02, With Invitation, Bankok
  6. A double sex-determining gene in the frog, Ikuo Miura, IAE seminar, university of Canberra, 2015/03/06, With Invitation
  7. Functional analyses of Sox3 for sex determination in XY and ZW systems in the frog, Ikuo Miura, Miniworkshop, University of Canberra, 2015/05/04, With Invitation
  8. Renewal of sex chromosome and a novel sex-determining mechanism, Ikuo Miura, Wildlife genetics lab meeting of University of Canberra, 2015/05/06, With Invitation
  9. Recent topics on sex of the frog Rana rugosa, Ikuo Miura, Workshop on Evolution of sex chromosomes and sex determination in vertebrates, 2011/04/20, With Invitation
  10. An exceptional frog proves the rule of heterogametic sex shift, Ikuo Miura, International symposium of gonad and brain sex differentiation, 2008/09/14, With Invitation
  11. Exciting sex in frogs: sex chromosome and sex determination, Ikuo Miura, University of Helsinki, 2005/05/11, With Invitation
  12. Boring karyotypes but exciting sex in frogs, Ikuo Miura, Australian National University, 2005/04/13, With Invitation
  13. Evolution of sex-determining mechanisms in Amphibia, Ikuo Miura, Indiana University, 1998/05/17, With Invitation
  14. Comparative genomics of sex chromosomes in amniotes: Lessons from reptiles, The 5th Asian Chromosome Colloquium, 2015/04/29, Without Invitation
  15. Intra-chromosomal distribution pattern of DNA methylcytosine and 5-hydroxymethylcytosin in mitogen-induced amphibian peripheral blood cells, Kubiura M, Miura I, Tada M, The 5th Asian Chromosome Colloquium, 2015/05/01, Without Invitation
  16. Evolution of the Sado-frog, a newly described species, in the small Japanese island, Miura I, Ogata M, Sekiya K, and Ohtani, International symposium Frontiers in Amphibian Biology: Endangered species conservation and genome editing, 2014/03/27, Without Invitation
  17. Functional analysis of the sex-linked gene SOX3 for female determination in the frog, Miura I, Ogata M, Hasegawa Y, and Ohtani H, International symposium Frontiers in Amphibian Biology: Endangered species conservation and genome editing, 2014/03/28, Without Invitation
  18. A battle between the XY and ZW systems in Japanese frog, Miura I and Ogata M, Evolution of sex determination mechanisms, 2012/06/06, Without Invitation
  19. Evolution of gonadal sex-differentiation mechanism from sex hormone dependent to independent in frog, Miura I, Ohtani H, Koizumi Y, and Ogata M, Sixth international symposium on the biology of vertebrate sex determination, 2012/04/23, Without Invitation
  20. Cutaneous pigment Cells in three types of spontaneous color mutant of the frog Rana rugosa, Ichikawa Y, Ohtani H, and Miura I, The 2nd Joint Seminar between Andalas University and Prefectural University of Hiroshima, 2009/08/13, Without Invitation
  21. The W chromosome evolution and sex-linked gene expression in the Japanese frog Rana rugosa, Miura, I., Ezaz, T., Ohtani, H., Uno, Y., Nishida, N., Matsuda, Y., and Graves, JAM, Fifth international syumposium on the biology of vertebrate sex determination, 2009/04/20, Without Invitation
  22. Molecular cytogenetic study on the origin and evolution of sex chromosomes in different genetic forms of the Japanese wrinkled frog (Rana rugosa, Ranidae), Uno, I., Nishida, C., Oshima, Y., Yokoyama, S., Miura, I., Nakamura, M. and Matsuda, Y., The 3rd Asian chromosome colloquim, 2008/12/01, Without Invitation
  23. Molecular characterization of ZW sex chromosomes and the prototype chromosomes in the frog Rana rugosa, Miura, I., Tariq, E., Ohtani, H. and Graves JAM, The 3rd Asian chromosome colloquim, 2008/12/01, Without Invitation
  24. The W-chromosome linked glycoprotein is differentially expressed between the male and female gonads of frog, Miura, I., Ohtani, H., Ezaz T., and Graves JAM, 4th inter national symposium on the biology of vertebrate sex determination, 2006/04/10, Without Invitation
  25. The early stages of sex chromosome evolution in the frog: before and after the establishment of the heteromorphic state, Miura, I., Ohtani, H. and Ichikawa, Y, XIX International congress of genetics, 2003/07/06, Without Invitation
  26. The sex chromosomes, XX/XY and ZZ/ZW, of Rana rugosa experienced a different type of sex bias during its differentiation, Miura, I., Ohtani, H. and Ichikawa, Y, 14th International chromosome conference, 2001/09/04, Without Invitation
  27. Effects of Styrene Monomer and Trimer on Gonadal Sex Differentiation of Genetic Males of the Frog Rana rugosa, Ichikawa, Y., Ohtani, H., Miura, I., Iwamoto, E. and Fukuhara, T, International Symposium on Environmental Endocrine Desruptors 2000, 2000/12/16, Without Invitation
  28. Change of the heterogametic sex, Ogata, M., Ohtani, H., Hasegawa, Y., Ichikawa, Y. and Miura, I, 14th Asian herpetological conference, 2000/07/16, Without Invitation
  29. Differential expression of a sex-linked gene, ADP/ATP translocase, between the Z and W chromosomes of the frog Rana rugosa, Saitoh, K., Ohtani, H., Nakamura, M., Ichikawa, Y. and Miura, I, The frontiers of the biology of amphibia, 1999/05/22, Without Invitation
  30. Estrogen-dependent ovary differentiation opens its gate just for a day during the development of the frog Rana rugosa, Ohtani, H., Miura, I. and Ichikawa, Y, The frontiers of the biology of amphibia, 1999/05/22, Without Invitation
  31. Morphological difference between yellow and red xanthophores in Japanese newts, Matsui, K., Miura, I., Takase, M. and Nakamura, M, XVII International pigment cell conference, 1999/08, Without Invitation
  32. Differential expression of a sex-linked gene, ADP/ATP translocase, from the Z and W chromosomes of the frog Rana rugosa, Miura, I, Ohtani, H., Nakamura, M., Ichikawa, Y. and Saitoh, K, International symposium on X chromosome inactivation in mammals, 1999/09/06, Without Invitation

Works, etc.

  1. DNA music (CD), Ikuo Miura, HoxA13 of giant salamander and human, Mitochondrial genes of giant salamander, 2005/04, Bioscience and Industry, Vol.63(3):192-195, attached CD

Social Activities

History as Committee Members

  1. Director, 2007/04, 2016/08, The Society of Chromosome Research
  2. Councillor, 2006/04, 2007/03, The Society of Chromosome Research
  3. Editorial Board, 2010/01, Asian Herpetological Research
  4. Editorial Boad, 2010/04, Chromosome Science
  5. Editorial Boad, 2014/04, Sexual Development
  6. Editorial Board, 2013/01, Dataset Papers in Biology
  7. Editorial Board, 2017, Bionomina
  8. An expert for the international committee on amphibian and reptiles anomalies, 2016, Ural Federal University (Russia)
  9. Reviewer, 2013/03, Narodowe Centrum Nauki
  10. Reviewer, 2017/06/12, 2017/06/12, the Czech Science Foundation
  11. Reviewer, 2013/08, the Czech Science Foundation
  12. Lecturer, 2015/03, University of Canberra
  13. Lecturer, 2014/11, SOKENDAI (The Graduate University for Advanced Studies)
  14. Lecturer, 2012/11, University of Tokyo
  15. Lecturer, 2000/06, Niigata University
  16. Th Research leader of Super science high school profect, 2005/04, 2010/03, Hirosima Kokutaiji High-School
  17. The research leader of Super Science High-School Project, 2002/04, 2005/03, Hiroshima Kokutaiji High School

Organizing Academic Conferences, etc.

  1. The 68th meeting of the society of chromosome research, Organizer, 2017/10, 2017/10
  2. Turnover of sex chromosomes in frogs and fish, 2016/08, 2016/08
  3. 2013/05, 2013/05

History as Peer Reviews of Academic Papers

  1. 2017, Molecular Biology and Evolution, 2
  2. 2017, Zoological Science, 1
  3. 2017, Genetica, 1
  4. 2017, Journal of the Royal Society Interphase
  5. 2017, the Herpetologica, 1
  6. 2017, Caryologia, 1
  7. 2016, Scientific Reports, 1
  8. 2016, Molecular Ecology, 1
  9. 2016, Evolution, 2
  10. 2016, Molecular Biology and Evolution, 1
  11. 2016, Sexual Development, 3
  12. 2016, Chromosome Research, 1
  13. 2016, Zoological Science, 2
  14. 2016, Cytogenetics and Genome Research, 1
  15. 2016, Invasive Species Compedium, 1
  16. 2016, Chromosome Science, 1
  17. 2016, BioMed Research International, 1
  18. 2015, BioMed Research International, 1
  19. 2015, Sexual Development, 1
  20. 2015, Evolution, 1
  21. 2015, Zoological Science, 1
  22. 2014, Genetica, 1
  23. 2014, Proceedings B, 1
  24. 2013, Cytogenetic and Genome Research, 3
  25. 2013, Zoological Science, 1
  26. 2013, Bulletin of the Herpetological Society of Japan, 1
  27. 2013, Journal Phyllomedusa, 1
  28. 2013, Evolution, 1
  29. 2013, National Science Centre, 1
  30. 2012, Cytogenetic and Genome Research, 1