Last Updated :2020/09/16

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
Other Contact Details
1-4-4, Kagamiyama, Higashi-Hiroshima 739-8528 JAPAN, Japan
TEL : (+81)82-424-7899 FAX : (+81)82-424-3741

Basic Information

Major Professional Backgrounds

  • 2019/04, Hiroshima University, Program of Food and AgriLife Science, Applied Molecular & Cellular Biology Program, Assistant Professor
  • 2015/04, 2019/03, Hiroshima University Graduate School of Biosphere Science, postdoctoral researcher
  • 2013/04, 2015/03, Japan Society for the Promotion of Science, Research Fellowship for Young Scientists
  • 2011/09, 2012/10, Innovation Training Program for Young Technical Experts Working, Researcher

Educational Backgrounds

  • Kindai University Faculty of Biology-oriented science and technology, 2005/04, 2009/03
  • Hiroshima University Graduate School of Biosphere Science, 2009/04, 2011/03
  • Hiroshima University Graduate School of Biosphere Science, 2011/04, 2015/03

Academic Degrees

  • Hiroshima University
  • Hiroshima University

Research Fields

  • Agricultural sciences;Animal life science;Integrative animal science
  • Biology;Basic biology;Animal physiology / Animal behavior
  • Biological Sciences;Genome science;Genome biology

Research Keywords

  • communication
  • Genome regulation
  • life physiology
  • Reproductive endocrinology
  • animal physiology

Affiliated Academic Societies

  • Japan Society of Reproductive Endocrinology
  • Japan society for reproductive medicine
  • Japan Society of Fertilization and Implantation
  • The Society for reproduction and development

Educational Activity

Course in Charge

  1. 2020, Undergraduate Education, Intensive, Laboratory Work in General Biology II

Research Activities

Academic Papers

  1. Impact of lipopolysaccharide administration on luteinizing hormone/choriogonadotropin receptor (Lhcgr) expression in mouse ovaries, Journal of Reproductive Immunology, 2020
  2. Itaconate regulates the glycolysis/pentose phosphate pathway transition to maintain boar sperm linear motility by regulating redox homeostasis, Free Radical Biology and Medicine, 2020
  3. Pretreatment of ovaries with collagenase before vitrification keeps the ovarian reserve by maintaining cell-cell adhesion integrity in ovarian follicles, Scientific reports, 10(6841), 2020
  4. TLR2/4 signaling pathway mediates sperm-induced inflammation in bovine endometrial epithelial cells in vitro, PLoS One, 14(4), 2019
  5. Gene Expression and Protein Synthesis in Mitochondria Enhance the Duration of High-Speed Linear Motility in Boar Sperm, Front Physiol, 12(10), 252, 2019
  6. Mitochondrial protein turnover is critical for granulosa cell proliferation and differentiation in antral follicles, Journal of the Endocrine Society, 3, 324-339, 2019
  7. Creatine enhances the duration of sperm capacitation: a novel factor for improving in vitro fertilization with small numbers of sperm, Hum Reprod, 33, 1117-1129, 2018
  8. The Cell Type-Specific Expression of Lhcgr in Mouse Ovarian Cells: Evidence for a DNA-Demethylation-Dependent Mechanism, Endocrinology, 159, 2062-2074, 2018
  9. Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice, PLoS One, 13, 2018
  10. The acceleration of reproductive aging in Nrg1flox/flox;Cyp19- Cre female mice, Aging cell, 16, 1288-1299, 2017
  11. Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice, Endocrinology, 157, 4899-4913, 2016
  12. De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility, Endocrinology, 157, 2160-2172, 2016
  13. Targeted disruption of Nrg1 in granulosa cells alters the temporal progression of oocyte maturation, Mol Endocrinol, 28, 706-721, 2014
  14. Endogenous acetaldehyde toxicity during antral follicular development in the mouse ovary, Reprod Toxicol, 33, 322-330, 2012
  15. Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human, Fertil Steril, 98, 471-479, 2012
  16. LH-induced neuregulin 1 (NRG1) type III transcripts control granulosa cell differentiation and oocyte maturation, Mol Endocrinol, 25, 104-116, 2011
  17. The proliferation of granulosa cells during ovarian follicular development ~the regulatory mechanisms and the physiological roles to acquire the responsible ability to ovulation stimuli~, Journal of Mammalian Ova Research, 37(1), 2020
  18. Negative effects of ROS generated during linear sperm motility on gene expression and ATP generation in boar sperm mitochondria, Free Radic Biol Med, 15(141), 159-171, 2019
  19. 卵胞発育の生理: 卵胞発育と卵成熟, 70(12), 1110-1116, 2016

Invited Lecture, Oral Presentation, Poster Presentation

  1. Lipopolysaccharides infusion into the uterus causes inflammation in the mammary gland., Fika Yuliza Purba, Tomoko Kawai, Masayuki Shimada, Takahiro Nii, Yukinori Yoshimura, Naoki Isobe, The 127th Annual Meeting of Japanese Society of Animal Science, 2020/03, Without Invitation, Kyoto
  2. Dramatic epigenetic changes in the genome impact gene expression and the differentiation of ovarian granulosa cells, Tomoko Kawai, Hoque SAM, Richards JS, Masayuki Shimada, 52 th Annual Meeting of Society for the Study of Reproduction, 2019/07, Without Invitation, San Jose, USA
  3. The pretreatment with collagenase before vitrification improves the ovarian reserve due to the maintenance of the cell-cell attachments with oocyte and granulosa cells, Tomoko Kawai, Masayuki shimada, the 35th ESHRE Annual Meeting, 2019/06, Without Invitation, Vienna, Austria
  4. Mitochondrial protein turnover is critical for granulosa cells proliferation and differentiation during the follicular development process, Hoque SAM, Tomoko Kawai, Zhendong Zhu, Masayuki Shimada, The 23th Japan Society of Reproductive Endocrinology, 2018/12, Without Invitation, Fukuoka
  5. The cell type-specific expression of Lhcgr in mouse ovarian cells during follicular development process: evidence for a DNA-demethylation dependent mechanism, Tomoko Kawai, Hoque SAM, Richards JS, Masayuki Shimada, 51 th Annual Meeting of Society for the Study of Reproduction, 2018/07, Without Invitation, New Orleans, USA
  6. Sensing sperm by bovine uterine epithelial cells via TLR2 and TLR4 signaling pathway in vitro, Akio Miyamoto, Mohamed A Ezz, Ahmed E Elweza, Mohamed A Marey, Tomoko Kawai, Maike Heppelmann, Christiane Pfarrer, Kazuhiko Imakawa, Samy M Zaabel, Masayuki Shimada, 51 th Annual Meeting of Society for the Study of Reproduction, 2018/07, Without Invitation, New Orleans, USA
  7. Pin1 functions during early cleavage division in mouse embryo, Yumi Hoshino, Takuma Miyamoto, Tomoko Kawai, Takafumi Uchida, Masayuki Shimada, 4 th World Congress of Reproductive Biology, 2017/09, Without Invitation, Okinawa, Japan
  8. CYP26b1-induced degradation of retinoic acid is essential for the differentiation of trophoblast cells, Tomoko Kawai, Masayuki Shimada, 50 th Annual Meeting of Society for the Study of Reproduction, 2017/07, Without Invitation, Washington, USA
  9. The role of fibronectin accumulated within cumulus-oocyte complex in mouse oocyte maturation, Hiroya Kitasaka, Tomoko Kawai, Takashi Umehara, Noritaka Fukunaga, Yoshimasa Asada, Masayuki Shimada, European Society of Human Reproduction and Embryology, 2017/07, Without Invitation, Geneva, Switzerland
  10. Cell type-specific demethylation of LH Receptor (Lhcgr) promoter regions facilitates FSH mediated induction of Lhcgr in murine granulosa cells of preovulatory follicles, Tomoko Kawai, Richards JS, Masayuki Shimada, 49 th Annual Meeting of Society for the Study of Reproduction, 2016/07, Without Invitation, San Diego, USA
  11. Retinoic acid regulates methylation of the promoter and expression of Lhcgr granulosa cells during follicular development., Tomoko Kawai, Noriyuki Yanaka, Yasuhisa Yamashita, Richards JS, Masayuki Shimada, 47 th Annual Meeting of Society for the Study of Reproduction, 2014/07, Without Invitation, Michigan, USA
  12. Metabolomics analysis of human embryo cultured media for the discovery of a marker judging good quality embryo, Tetsunori Mukaida, Tomoko Kawai, Masayuki Shimada, Katsuhiko Takahashi, 68 th Annual Meeting of American Society for Reproductive Medicin, 2012/10, Without Invitation, California, USA
  13. The Expression of Acetaldehyde Dehydrogenase (ALDH) Type 1 Family Members Is Required to Decrease of Endogenous Acetaldehyde Toxicity During Ovarian Follicular Development in Mouse and Human, Masayuki Shimada, Tomoko Kawai, Ikko Kawashima, Richards JS, Youko Fujita, Chiaki Ikeda, Hiroaki Negishi., 44 th Annual Meeting of Society for the Study of Reproduction, 2011/07, Without Invitation, Portland, USA


  1. 2018, 51st Society for the Study of Reproduction Annual Meeting Best international abstract award
  2. 2009, 近畿大学 学部長賞

External Funds

Acceptance Results of Competitive Funds

  1. 2020/07, 2021/03
  2. 2019/10, 2020/03
  3. 2013/04, 2015/03