SATOSHI KOFUJI

Last Updated :2019/11/13

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), ., Assistant Professor
E-mail
sakofujihiroshima-u.ac.jp

Basic Information

Academic Degrees

  • The University of Tokyo
  • The University of Tokyo

Educational Activity

Course in Charge

  1. 2019, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  2. 2019, Undergraduate Education, 2Term, Physiological Chemistry
  3. 2019, Undergraduate Education, Second Semester, Experiments of Biological Chemistry
  4. 2019, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  5. 2019, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  6. 2019, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  7. 2019, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  8. 2019, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students

Research Activities

Academic Papers

  1. In-vitro evaluation of MPA-loaded electrospun coaxial fiber membranes for local treatment of glioblastoma tumor cells., J Drug Delivery Science Technology, 40, 45-50, 2017
  2. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia., Cell Report, 18(9), 2088-2095, 2017
  3. microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma., Oncotarget, 8(13), 20881-20894, 2017
  4. Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways., J Clin Invest., 126(11), 4088-4102, 2016
  5. Structural reverse genetics study of the PI5P4Kbeta-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells., FEBS J, 283(19), 3556-3562, 2016
  6. The lipid kinase PI5P4Kbeta is an intracellular GTP sensor for metabolism and tumorigenesis., Molecular Cell, 61(2), 187-198, 2016
  7. INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor., Cancer Discovery, 5(7), 730-739, 2015
  8. Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment., Oncotarget, 6(12), 10548-10562, 2015
  9. A Review of the Potential Utility of Mycophenolate Mofetil as a Cancer Therapeutic., Journal of Cancer Research, 423401, 2014
  10. Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine., Proc Natl Acad Sci U S A., 110(5), 1726-1731, 2013
  11. The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death., Nature, 465(7297), 497-501, 2010
  12. Mammalian phosphoinositide kinases and phosphatases., Prog Lipid Res., 48(6), 307-343, 2009
  13. The decapping enzyme Dcp1 participates in translation termination through its interaction with the release factor eRF3 in budding yeast., Biochemical and Biophysical Research Communications, 344(2), 547-553, 2006
  14. Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human., Journal of Biochemistry, 136(6), 805-812, 2004
  15. PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2 alpha-Targeting Therapy for Renal Cell Carcinoma, CANCER RESEARCH, 77(22), 6321-6329, 20171115
  16. TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis, JOURNAL OF CELL SCIENCE, 131(5), 201803
  17. PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel., Journal of Biochemistry, 2018
  18. Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages., Genes to Cells, 2019
  19. Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages, GENES TO CELLS, 24(5), 366-376, 201905
  20. Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(6), 923-928, 201906
  21. IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma., Nature Cell Biology, 21(8), 1003-1014, 201908
  22. Dynamic compartmentalization of purine nucleotide metabolic enzymes at leading edge in highly motile renal cell carcinoma., Biochem Biophys Res Commun, 516(1), 50-56, 201908
  23. Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning., J Biochem, 166(2), 175-185, 201908
  24. Identification of lysine methylation in the core GTPase domain by GoMADScan., PLoS One, 14(8), e0219436, 20190807
  25. Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story., Cancers, 11(9), pii: E1346, 20190911