SHUICHI FURUSAWA

Last Updated :2019/07/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, ., Professor
E-mail
sfurusa?at?hiroshima-u.ac.jp
Other Contact Details
1-4-4,Kagamiyama,Higashi-Hiroshima, Japan
TEL : (+81)82-424-7967 FAX : (+81)
Self-introduction
We accept widely the student who is interested in immunobiology.

Basic Information

Major Professional Backgrounds

  • 1979/04/01, 1984/07/31, Teikyo University, Research Assistant
  • 1981/04/01, 1981/09/30, Harverd Medical School, Assistant Researcher
  • 1984/08/01, 1985/03/31, Teikyo University, Research Assistant
  • 1985/01/01, 1990/07/31, Teikyo University, Faculty of Medicine, Assistant Professor
  • 1985/03/01, 1987/05/01, New York University, School of Medicine, Professional Researcher
  • 1990/08/01, 2007/09/30, Hiroshima University, Faculty of Applied Biological Science, Associate Professor
  • 1990/12/01, 1992/09/30, New York University, Faculty of Medicine, Visiting Associate Professor
  • 1992/10/01, 1995/03/31, the Ministry of Agriculture, Forestry and Fisheries, National Institute of Animal Health, Senior Researcher
  • 1995/04/01, 2004/03/31, Hiroshima University, Faculty of Applied Biological Science, Associate Professor
  • 2004/04/01, Hiroshima University, Graduate School of Biosphere Sciendce, Professor

Educational Backgrounds

  • Toho University, Faculty of Science, Japan, 1974/04, 1979/03

Academic Degrees

  • Doctor of Medical Science, Teikyo University

Educational Activity

  • 【Bachelor Degree Program】School of Applied Biological Science : Department of Applied Biological Science
  • 【Master's Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • 【Doctoral Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

In Charge of Primary Major Programs

  • Applied Molecular and Cellular Biology

Research Fields

  • Agricultural sciences;Animal life science;Integrative animal science

Research Keywords

  • T cell, Chicken
  • LIF, germinal center
  • gene conversion, chicken
  • acquired immunity, antibody
  • monoclonal antibody, Ayu fish
  • memory B cell, class switch
  • transgenic chicken
  • immunoglobulin
  • innate immunity
  • immuniglobulin

Affiliated Academic Societies

  • Japanese Society for Immunology, 1978
  • The Japanese Association for Developmental & Comparative Immunology, 1991
  • The Japanese Society of Veterinary Science, 1992
  • The American Association of Immunologists, 1983

Educational Activity

Course in Charge

  1. 2019, Liberal Arts Education Program1, 4Term, Biological production and natural environment
  2. 2019, Liberal Arts Education Program1, 3Term, Cell Science
  3. 2019, Undergraduate Education, Intensive, Laboratory Work in General Biology I
  4. 2019, Undergraduate Education, 4Term, Introduction to Applied Biological Science II
  5. 2019, Undergraduate Education, 3Term, Immunobiology
  6. 2019, Undergraduate Education, Intensive, Laboratory Work in Immunobiology
  7. 2019, Undergraduate Education, 2Term, Animal Cell Technology
  8. 2019, Undergraduate Education, Academic Year, Graduation Thesis
  9. 2019, Graduate Education (Master's Program) , First Semester, Practice in Molecular and Applied Biosciences
  10. 2019, Graduate Education (Master's Program) , Second Semester, Research for Academic Degree Dissertation
  11. 2019, Graduate Education (Master's Program) , 1Term, Immunobiology
  12. 2019, Graduate Education (Master's Program) , 2Term, Molecular immmunology

Research Activities

Academic Papers

  1. Analysis of T cell hybridomas. 2. Comparisons among three distinct type of monoclonal suppressor factors., J. Exp. Med., 154, 1838-1851, 1981
  2. Analysis of T cell hybridomas. 1.Characterization of H-2 and Igh restricted monoclonal suppressor factors., J. Exp. Med., 154, 1390-1402, 19810401
  3. I-J restriction on the activation and interaction of parental and F1-derived Ts3 suppressor cells., J. Exp. Med., 156, 465-479, 19820401
  4. Analysis of T cell hybridomas. 4. Characterization of inducible suppressor cell hybridomas., J. Exp. Med., 157, 1379-1395, 19830401
  5. Production of IL-1 alpha and beta by human peripheral polymorphonuclear neutrophils., Int. Archs. Allergy Appl. Immunol, 88, 297-303, 19870401
  6. Study on immunity in hybridoma bearing mice. A immune response to antigens. 2. Inhibition of production of anti-dinitrophenyl antibodies in mice which have rejected the B53 anti-DNP producing IgE hybridoma., Int. Archs. Allergy Appl. Immunol, 83, 414-422, 19870401
  7. Differences in fine specificities between monoclonal antibodies directed against dinitrophenyl and trinitrophenyl haptens., Int. Archs. Allergy Appl. Immunol, 85, 238-243, 19870401
  8. A novel method to investigate the heterocliticity of antibodies., J. Immunol. Methods, 104, 275-279, 19870401
  9. The suppressive effect of histamine on anti-DNP antibody production in mice., Int. Archs. Allergy Appl. Immunol, 86, 391-399, 19870401
  10. Regulation of murine IgE production in SJA/9 and nude mice. Potentiation of IgE production by recombinant interleukin-4., J. Immunol., 139, 2588-2544, 19870401
  11. Anti-idiotypic antibodies as a mirror image of the paratope of the original antibody., Int. Archs. Allergy Appl. Immunol, 84, 263-270, 19870401
  12. Study on murine IgE with monoclonal antibodies. 1. Characterization of rat monoclonal anti-IgE antibodies and the use of these antibodies for determination of serum IgE levels and for anaphyratic reactions.,, Int. Archs. Allergy Appl. Immunol, 85, 47-54, 19880401
  13. Detection of interleukin-1 in ascites from cats with feline infectious of peritonitis., J. Vet. Med. Sci., 53, 487-489, 19910401
  14. Suppressive effect of intravenous immunoglobulins on the activity of interleukin 1., Immunol. Res., 13, 49-66, 19940401
  15. Delayed type hypersensitivity response in mice transplanted with rat hepatocytes., J. Vet. Med. Sci., 56, 1143-1148, 19940401
  16. Murine IgG1 and IgE memory B cells., Cell. Immunol., 157, 369-380, 19940401
  17. Molecular cloning and expression of canine interleukin 8 cDNA., Cytokine, 6, 455-461, 19940401
  18. Granulocyte Colony-Stimulating Factor (G-CSF) and Granulocyte Macrophage Colony-stimulating Factor (GM-CSF) in Behcets Disease., J. Dermatlogy, 21(8), 546-552, 19940401
  19. Detection of the Chemotactic Factor for Canine Peripheral Blood Mononuclear Cells and Polyporphonuclear Cells in the Culture Supernatant of Cos7 Cells Transfected with Canine Interleukin-8 cDNA., J. Vet. Med. Sci., 57(4), 603-610, 19950401
  20. Effects of 6-Hydroxydopamine on the antibody response to the hapten dinitrophenyl in the chicken., J. Vet. Med. Sci., 57, 1073-1075, 19950401
  21. Enhancing effect of chicken egg white derivatives on the phagoccytic response in the dog., J. Vet. Med. Sci., 57, 825-829, 19950401
  22. Flow cytometric analysis and immunohistochemistry of delayed-type hypersensitivity response in mice immunized with rat hepatocytes., J. Vet. Med. Sci., 57, 245-249, 19950401
  23. Production and characterization of polyclonal anti-canine interlerukin-8 antibodies., J. Vet. Med. Sci., 58(3), 219-224, 19960401
  24. Immunoglobulin gene hyperconversion ongoing in chicken splenic germinal centers., EMBO J., 15, 2540-2546, 19960401
  25. Two chicken B cell lines resistant to ouabain for the production of chicken monoclonal antibodies, The Journal of Veterinary Medical Science, 58(11), 1053-1056, 19961101
  26. IgE memory B cells identified by the polymerase chain reaction., Cell. Immunol., 176, 34-40, 19970401
  27. Manipulation of chick embryo and production of transgenic chicken., 3(4), 39-44, 19980401
  28. Development of Maternal IgG free chick obtained from surgically bursectomized hen., Comp. Immunol. Microbiol.Infect. Disease, 21, 191-200, 19980401
  29. Chicken monoclonal antibodies against synthetic bovine prion protein peptide., J. Vet. Med. Sci., 60(6), 777-779, 19980601
  30. Association of B cell and T cell markers with immune response in chickens, Proceeding of the XXVI International Conference on Animal Genetics, 26(1), 50-51, 19980701
  31. A chicken monoclonal antibody with specificity for the N-terminal of human prion protein, FEMS Immunology and Medical Microbiology, 23(3), 189-194, 19990301
  32. CD3+CD4-CD8- cells present in chicken peripheral blood are regulated by aging and stress, CURRENT PROGRESS ON AVIAN IMMUNOLOGY RESEARCH, 6, 315-321, 20001008
  33. Construction of recombinant chicken monoclonal antibody using phage display system, CURRENT PROGRESS ON AVIAN IMMUNOLOGY RESEARCH, 6, 335-340, 20001001
  34. Construction of recombinant monoclonal antibodies from a chicken hybridoma line secreting specific antibody., Cytotechnology, 32, 191-198, 20000401
  35. Class switch recombination of the chicken immunoglobulin heavy chain genes : implications for the primordial switch region repeats, Int. Immunol., 12, 959-968, 20000401
  36. Expression of chicken gp130 mRNA in various chicken organs and cells, Proceedings of the International Veterinary Cytokine and Vaccine Conference, 330-333, 20000316
  37. cDNA cloning and mRNA expression of PDGF in chicken thrombocyte, Proceedings of the International Veterinary Cytokine and Vaccine Conference, 234-237, 20000316
  38. Construction of recombinant monoclonal antibodies from a chicken hybridoma line secreting specific antibody, CYTOTECHNOLOGY, 32(3), 191-198, 2000
  39. Influence of aging and estrogen treatment on the IgY concentration in the egg yolk of chicken., Japanese Poultry Science, 37(5), 280-288, 20000901
  40. Class switch recombination of the chicken IgH chain genes: implications for the primordial switch region repeats, INTERNATIONAL IMMUNOLOGY, 12(7), 959-968, 2000
  41. Localization of immunoglobulin G gamma-chain mRNA-expressing cells in the oviduct of laying and diethylstilbestrol-treated immature hens, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 120(3), 345-352, 2000
  42. Effects of forced molting on the IgY concentration in egg yolk of chickens., Journal of Poultry Science, 38(2), 169-174, 20010501
  43. Role of bursin in the development of B lymphocytes in chicken embryonic Bursa of Fabricius, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 25(42861), 485-493, 2001
  44. Expression of steroidogenic factor-1 in frog embryo and developing gonad, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 123(1), 13-22, 2001
  45. Characterization and expression of three forms of cDNA encoding chicken platelet-derived growth factor-A chain, GENE, 272(42737), 181-190, 20010711
  46. Establishment of monoclonal antibodies against chicken GP130, Veterinary Immunology Symposium, 6, 106, 20010715
  47. Cloning and characterization of a chicken platelet-derived growth factor B-chain cDNA, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 26(1), 73-83, 2002
  48. Studies on chicken cytokines: cloning and application, 46(2), 137-149, 20021201
  49. Immunobiology of chicken germinal center: I. Changes in surface Ig class expression in the chicken splenic germinal center after antigenic stimulation, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 27(2), 159-166, 2003
  50. Generation of antibodies against prion protein by scrapie-infected cell immunization of PrP0/0 mice, HYBRIDOMA AND HYBRIDOMICS, 22(4), 263-266, 2003
  51. Development of Peyer's patch and cecal tonsil in gut-associated lymphoid tissues in the chicken embryo, JOURNAL OF VETERINARY MEDICAL SCIENCE, 65(5), 607-614, 2003
  52. Two expression vectors for the phage-displayed chicken monoclonal antibody, JOURNAL OF IMMUNOLOGICAL METHODS, 280(42737), 157-164, 2003
  53. Flow cytometoric analysis of chicken NK activity and its use on the effect of restraint stress, JOURNAL OF VETERINARY MEDICAL SCIENCE, 65(9), 995-1000, 2003
  54. Immunobiology of chicken germinal center: II. Accumulation of apoptotic cells within the germinal center, CELL AND TISSUE RESEARCH, 314(2), 215-221, 2003
  55. Chicken peripheral blood CD3(+)CD4(-)CD8(-) cells are regulated by endocrine and nerve systems, JOURNAL OF VETERINARY MEDICAL SCIENCE, 66(2), 143-148, 2004
  56. A monoclonal antibody against chicken thrombocytes reacts with the cells of thrombocyte lineage, JOURNAL OF VETERINARY MEDICAL SCIENCE, 66(3), 243-250, 2004
  57. Molecular study on chicken tumor necrosis factor receptor-II and tumor necrosis factor receptor-associated factor-5, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(42737), 31-41, 2004
  58. Chicken leukemia inhibitory factor maintains chicken embryonic stem cells in the undifferentiated state, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(23), 24514-24520, 20040604
  59. Cloning and characterization of chicken tumor necrosis factor (TNF)-superfamily ligands, CD30L and TNF-related apoptosis inducing ligand (TRAIL), JOURNAL OF VETERINARY MEDICAL SCIENCE, 66(6), 643-650, 2004
  60. Establishment of a chicken monoclonal antibody panel against mammalian prion protein, JOURNAL OF VETERINARY MEDICAL SCIENCE, 66(7), 807-814, 2004
  61. Biological activities of recombinant chicken interleukin-6 on chicken hybridoma cells., Avian Immunology Research Group, 8, 85, 20040904
  62. Cloning and characterization of a chicken leukemia inhibitory factor, Avian Immunology Research Group, 8, 80, 20040904
  63. Genomic organization of the chicken T-Cell receptor beta chain D-J-C region, JOURNAL OF VETERINARY MEDICAL SCIENCE, 66(12), 1509-1515, 2004
  64. Expression vectors for chicken-human chimeric antibodies, BIOLOGICALS, 32(4), 213-218, 2004
  65. Characterization and expression analysis of the chicken interleukin-11 receptor alpha chain, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 29(4), 349-359, 2005
  66. Excision of foreign gene product with cathepsin D in chicken hepatoma cell line, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 330(2), 533-539, 20050506
  67. Generation of a mouse monoclonal antibody against chicken interleukin-6, HYBRIDOMA, 24(2), 115-117, 2005
  68. Biological activity of recombinant chicken interleukin-6 in chicken hybridoma cells, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 106(42737), 97-105, 20050615
  69. Inhibition of prion propagation in scrapie-infected mouse neuroblastoma cell lines using mouse monoclonal antibodies against prion protein, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 335(1), 197-204, 20050916
  70. Stable production of recombinant chicken antibody in CHO-K1 cell line, BIOLOGICALS, 33(3), 169-174, 2005
  71. Characterization and expression analysis of a chicken interleukin-6 receptor alpha, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 30(4), 419-429, 2006
  72. Effect of novel monoclonal antibodies on LIF-induced signaling in chicken blastodermal cells, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 30(5), 513-522, 2006
  73. Maintenance of chicken embryonic stem cells in vitro., In Methods in Molecular Biology (Embryonic Stem Cell Protocols; Second Edition Vol. 1), 329, 17-34, 20060401
  74. Antibody engineering and transgenic technology in chickens, Food and Food Ingredients Journal of Japan, 211(11), 948-954, 20061101
  75. Humanization of chicken monoclonal antibody using phage-display system, MOLECULAR IMMUNOLOGY, 43(6), 634-642, 2006
  76. Cloning of the chicken interleukin-13 receptor alpha 2 gene and production of a specific monoclonal antibody, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 31(4), 394-406, 2007
  77. Development of recombinant chicken IgY from single chain fragment of variable region for diagnosis of BSE, BIOLOGICALS, 35(1), 31-34, 2007
  78. Effect of prenatal administration of NSAIDs on the immune response in juvenile and adult rats, TOXICOLOGY, 232(3), 257-267, 20070411
  79. Chicken antibody against a restrictive epitope of prion protein distinguishes normal and abnormal prion proteins, BIOLOGICALS, 35(4), 303-308, 2007
  80. Construction of chicken-mouse chimeric antibody and immunogenicity in mice, JOURNAL OF VETERINARY MEDICAL SCIENCE, 70(4), 397-400, 2008
  81. Prenatal administration of indomethacin modulates Th2 cytokines in juvenile rats, TOXICOLOGY LETTERS, 185(1), 32-37, 20090225
  82. Prolonged Suppression of Chick Humoral Immune Response by Antigen Specific Maternal Antibody, JOURNAL OF VETERINARY MEDICAL SCIENCE, 71(4), 417-424, 2009
  83. Quantitative estimation of Flavobacterium psychrophilum infected ayu Plecoglossus altivelis altivelis by real-time PCR, NIPPON SUISAN GAKKAISHI, 75(2), 258-260, 2009
  84. Generation and characterization of chicken monoclonal antibodies against human LOX-1, MABS, 1(4), 357-363, 2009
  85. Generation and characterization of chicken monoclonal antibodies against human LOX-1., MAbs., 1(4), 357-363, 20090401
  86. Construction of an Insertion Vector for Gene Targeting of Chicken Lens-specific Gene, JOURNAL OF POULTRY SCIENCE, 47(2), 144-148, 2010
  87. Induction of Immune Suppression in the Chick by an Optimal Dose of an Immunizing Antigen in the Presence of its Specific Maternal Antibody, JOURNAL OF VETERINARY MEDICAL SCIENCE, 72(3), 257-262, 2010
  88. Quantitative estimation of Flavobacterium psychrophilum discharged from infected ayu Plecoglossus altivelis altivelis by real-time PCR, NIPPON SUISAN GAKKAISHI, 76(4), 705-707, 2010
  89. Characteristics of Novel Chicken Embryonic Stem Cells Established Using Chicken Leukemia Inhibitory Factor, JOURNAL OF POULTRY SCIENCE, 48(1), 64-72, 2011
  90. Molecular cloning of chicken interleukin-5 receptor alpha-chain and analysis of its binding specificity, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 37(42798), 354-362, 2012
  91. Comparisons of Internal Behavior after Exposure to Flavobacterium psychrophilum between Two Ayu (Plecoglossus altivelis altivelis) Strains Showing Different Cumulative Mortality to Bacterial Cold Water Disease, JOURNAL OF VETERINARY MEDICAL SCIENCE, 75(12), 1571-1575, 2013
  92. Studies on Morphology and Cytochemistry in Blood Cells of Ayu Plecoglossus altivelis altivelis, JOURNAL OF VETERINARY MEDICAL SCIENCE, 76(5), 693-704, 2014
  93. Induction of non-specific suppression in chicks by specific combination of maternal antibody and related antigen, JOURNAL OF VETERINARY MEDICAL SCIENCE, 77(11), 1363-1369, 2015
  94. Expression of ayu antimicrobial peptide genes after LPS stimulation, The Journal of Veterinary Medical Science, 79(6), 2017
  95. Expression of ayu antimicrobial peptide genes after LPS stimulation, JOURNAL OF VETERINARY MEDICAL SCIENCE, 79(6), 1072-1080, 2017

Publications such as books

  1. 1982, Study of anti-LPS antibodies in Behcet’s disease, ’Behcet’s Disease. Pathogeneic Mechanism and Clinical Future (Ed. by G. Inaba), Tokyo Univ. Press., 1982
  2. 1984, Analysis of the suppressor T cell cascade with products derived from T cell hybridomas, ’Cell Fusion: Gene Transfer and Transformation’ (Ed. by R.F.Beers,Jr. & E.G.Basett), 抑制性T細胞の反応系を概説した。, Raven Press= New York, 1984, 890049416, 421
  3. 1995, Immediate hypersensitivity: A brief history, ’Immunology: The making of a modern science’, (Ed. by R.Gallagher, J.Gilder, G.Salvatore, G.Nossal), 即時型アレルギー反応の歴史と、現代までわかってきたことを概説した。, Academic Press= New York=, 1995
  4. 2006, Maintanance of chicken embryonic stem cells in vitro. “Embryonic stem cells-II, : Methods and Protocols” Ed by K. Turksen, Human Press Inc. Totowa, NJ, 2006, E, Horiuchi H., Furusawa,S., Matsuda H.
  5. 2006, Maintenance of chicken embryonic stem cells in vitro Embrionic Stem Cells-II Method in Molecular Biology, E, Horiuchi, H., Furusawa, S., Matsuda, H.
  6. 2011, Veterinary Immunology Immunology an Introduction 7th ed., J, 978-4-89995-456-9, 478, 478
  7. 2011/04, The world of Tomio Tada, In remembrance of Dr. Tada, Fujiwara, 2011, 04, 日本語, Shuichi Furusawa, ISBN-13: 9784894347984, 382, 5

Invited Lecture, Oral Presentation, Poster Presentation

  1. Internal quality guarantee system of the education in Hiroshima University, Shuichi Furusawa, Seminar on the internal quality guarantee systems construction of the education, 2013, With Invitation, National Institution for Academic Degree and Quality Enhancement of Higher Education, Tokyo, I gave a lecture on an internal quality guarantee system using the HiPROSPECTS and e-learning portfolio in Hiroshima University.
  2. Flipped Class Room in the Scientific Lecture -Trial of acquirement and the ability for applied development training of the knowledge-, Shuichi Furusawa, The 22nd Kyoto University Conference on Higher Education, 2016/03, With Invitation, Center for the Promotion of Excellence in Higher Education, Kyoto University, Kyoto

Awards

  1. 2011年10月26日, 10th Transgenic Technology (TT) meeting,Best Poster Award, Dr. Lluis Montoliu ISTT Executive Committee, President, Florida (USA), October 24-26 (2011)で開催された10th Transgenic Technology (TT) meetingでポスター発表を行い,発表の内容,ポスターのレイアウト等が高く評価

Patented

  1. Patent, JP3723839, 2005/09/30
  2. Patent, US:7029664, 2006/04/18
  3. Patent, EP:1264889, 2006/06/07
  4. Patent, US:7250275, 2007/07/31
  5. Patent, JP4029153, 2007/10/26
  6. Patent, JP4273230, 2009/03/13
  7. Patent, JP4304274, 2009/05/15
  8. Patent, US:7619080, 2009/11/17
  9. Patent, JP4452884, 2010/02/12
  10. Patent, US:7691589, 2010/04/06
  11. Patent, US:7771714, 2010/08/10
  12. Patent, JP4691650, 2011/03/04
  13. Patent, JP4830115, 2011/09/30
  14. Patent, JP4892717, 2012/01/06
  15. Patent, US:8198082, 2012/06/12
  16. Patent, JP5408618, 2013/11/15
  17. Patent, EP:2143791, 2014/04/23