岡本 哲治Tetsuji Okamoto

Last Updated :2019/12/02

所属・職名
大学院医系科学研究科(歯)(歯学)分子口腔医学・顎顔面外科学教授

基本情報

学位

  • 歯学博士(広島大学)
  • 歯学士(広島大学)

研究分野

  • 医歯薬学 / 歯学 / 外科系歯学

研究キーワード

  • 血管新生因子
  • 口腔癌
  • 血管内皮細胞増殖因子
  • 免疫療法
  • 自己増殖促進因子
  • 口腔癌
  • LAK

教育活動

授業担当

  1. 2019年, 教養教育, 2ターム, 全身の健康と口腔科学I[1歯][旧パッケージ]
  2. 2019年, 学部専門, セメスター(前期), 人類遺伝学
  3. 2019年, 学部専門, 4ターム, 歯学概論
  4. 2019年, 学部専門, 1ターム, 歯学研究特論I
  5. 2019年, 学部専門, セメスター(後期), 口腔外科学I
  6. 2019年, 学部専門, 1ターム, 口腔外科学II
  7. 2019年, 学部専門, 2ターム, 口腔外科学III
  8. 2019年, 学部専門, 3ターム, 顎口腔医療学基礎実習III
  9. 2019年, 学部専門, 4ターム, 顎口腔医療学基礎実習IV
  10. 2019年, 学部専門, 2ターム, 分子口腔医学・顎顔面外科学演習・実習
  11. 2019年, 学部専門, 2ターム, 臨床歯科医学総合演習
  12. 2019年, 学部専門, 年度, 臨床実習(口腔外科学I)
  13. 2019年, 学部専門, セメスター(前期), 口腔工学概論
  14. 2019年, 修士課程・博士課程前期, セメスター(前期), 口腔健康科学特論
  15. 2019年, 博士課程・博士課程後期, セメスター(前期), 分子口腔医学・顎顔面外科学特別演習
  16. 2019年, 博士課程・博士課程後期, セメスター(後期), 分子口腔医学・顎顔面外科学特別演習
  17. 2019年, 博士課程・博士課程後期, セメスター(前期), 分子口腔医学・顎顔面外科学特別実験
  18. 2019年, 博士課程・博士課程後期, セメスター(後期), 分子口腔医学・顎顔面外科学特別実験
  19. 2019年, 修士課程・博士課程前期, セメスター(前期), 口腔健康科学特論

研究活動

学術論文(★は代表的な論文)

  1. Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells, EMBO JOURNAL, 29巻, 7号, pp. 1192-1204, APR 7 2010
  2. Tissue culture: the unlimited potential, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 46巻, 7号, pp. 590-594, JUL 2010
  3. The influence of the Lop Nor Nuclear Weapons Test Base to the population of the Republic of Kazakhstan, RADIATION MEASUREMENTS, 46巻, 4号, pp. 425-429, APR 2011
  4. Growth factor-defined culture medium for human mesenchymal stem cells, INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 55巻, 2号, pp. 181-187, 2011
  5. ESR dosimetry study for the residents of Kazakhstan exposed to radioactive fallout on 24, August 1956, RADIATION MEASUREMENTS, 46巻, 9号, pp. 793-796, SEP 2011
  6. FGFR1 Abrogates Inhibitory Effect of Androgen Receptor Concurrent With Induction of Androgen-Receptor Variants in Androgen Receptor-Negative Prostate Tumor Epithelial Cells, PROSTATE, 71巻, 15号, pp. 1691-1700, NOV 2011
  7. Differentiation of Cultured Epidermal Keratinocytes related to sterol metabolism and its retardation by chemical carcinogens., Biochimia et Biophysca Acta, 805巻, 2号, pp. 143-51, 19841001
  8. Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line., Exp Cell Res, 163巻, 1号, pp. 117-26, 19860501
  9. Cholesterol requirement of P3-X63-Ag8 and X63-Ag8・653 mouse meyeloma cells for growth in vitro, Journal of Experimental Medicine, pp. 165, 19870401
  10. Effects of proximate cholesterol precusors and steroid hormons on mouse myleoma growth in serum-freemedium, In Vitro Cell. Dev. Biol., pp. 24, 19880401
  11. Malignant tumor cell line produce interleukin-1 like factor, In Vitro Cell. Dev. Biol., pp. 24, 19880401
  12. An alternative method for the Isolation of NS-1 hybridomas using cholesterol auxotrophy of NS-1 mouse myeloma cells., In Vitro Cell. Dev. Biol., pp. 25, 19890401
  13. Vascular endothelial cell growth factor (VEGF) produced by human epidermoid carcinoma cells and identification of UEGF membrane binding site., Proc. Natl. Acad. Sci. USA, pp. 88, 19910401
  14. Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors., J. Biol. Chem., 266巻, 25号, pp. 16778-85, 19910901
  15. 新しい光感受性色素(フェオフォバイド-a)を用いた口腔癌に対する光力学療法の基礎的研究, 日本口腔外科学会誌, 38巻, 5号, pp. 729-736, 19920401
  16. 無血清培養下における正常上皮細胞ならびに癌細胞の脂質代謝に及ぼす細胞増殖因子の影響, 日本口腔外科学会誌, 38巻, 3号, pp. 424-432, 19920401
  17. 下顎骨に発生した中心性巨細胞肉芽腫, 日本口腔外科学会誌, 38巻, 3号, pp. 514-515, 19920401
  18. 無血清培養下における正常口腔粘膜上皮細胞、唾液線上皮細胞ならびに口腔癌細胞の脂質代謝, 日本口腔外科学会誌, 38巻, 2号, pp. 222-228, 19920401
  19. 口腔領域悪性腫瘍組織における上皮成長因子受容体の発現(共著), 日本口腔外科学会誌, 37巻, 5号, pp. 937-943, 19910401
  20. 無血清培地を用いたLymphokine activated killer細胞の誘導(共著), 日本口腔外科学会誌, 37巻, 4号, pp. 779-787, 19910401
  21. ガンの免疫療法の新しい展開(共著), 広島大学歯学雑誌, 23巻, 2号, pp. 360-361, 19910401
  22. 口腔由来正常上皮細胞および口腔癌細胞の無血清培養下での増殖におよぼすEGF,FGFの影響ならびに受容体解析(共著), 日本口腔外科学会誌, 37巻, 8号, pp. 1454-1465, 19910401
  23. 正常マウス顎下線上皮細胞の無血清培養下における株化(共著), 日本口腔外科学会誌, 36巻, 4号, pp. 791-801, 19900401
  24. シスプラチン耐性細胞の分離と耐性発現機序(共著), 日本口腔腫瘍学会誌, 2巻, 1号, pp. 9-19, 19900401
  25. 血管付遊離腸移植による下顎骨再建を作った2症例, 日本口腔外科学会誌, 31巻, 2号, pp. 372-377, 19850401
  26. 培養マウス表皮角化細胞の分化過程におけるSterol代謝とそれに及ぼす化学発癌剤並びにtumor promterの影響, 広島大学歯学雑誌, 16巻, 1号, pp. 36-47, 19840401
  27. Effect of Fibroblast growth Factor-1 on the three dimensional growth and Mon phogenesis oF Human Salivary gland Epithelial cells embedded in collagen gels, In vitro Cellular and Developmental Biology Animal, 31巻, pp. 84-86, 19950401
  28. Release of fibroblast growth factor-1 by human squawous cell carcinoma correlates with auto crine cell growth, In Uitro Ceelular Pevelopmental biology, 30A巻, pp. 790-795, 19940401
  29. Primilive neuroectodewal tomor cells lines derived from a metastatic Pediatric tumor, In Uitro Cellular Developmental Biology, 394巻, pp. 813-816, 19940401
  30. Immunocytochemical localization of fibroblast growth factor-1 (FGF-1) and FGF-2 in Oral squamous cell carciuoma (SCC), J Oral Pathol Med, 23巻, pp. 451-456, 19940401
  31. Vascular Endothelial Growth factor induces the Disorganization of actin stress fibres accomparaied by protein tyrosine phosphorylation and Morphological change in Balb/c 3T3 cell., Biochemical and Biophysical Research Communication, 202巻, 3号, pp. 1716-1723, 19940401
  32. A novel heparin-binding protein, HBp15 is identified as mammalian ribosomal protein L22, Biochem. Biophys. Res. Comm., 199巻, 2号, pp. 706-713, 19940401
  33. 口腔扁平上皮癌におけるFGF-1およびFGF-2の発現, 日本口腔外科学会雑誌, 40巻, 8号, pp. 864-869, 19940401
  34. マウス顎下腺に存在する線維芽細胞増殖因子-1の精製,遺伝子クローニングならびに材能解析, 日本口腔外科学会誌, 40巻, 7号, pp. 707-716, 19940401
  35. Lymphokine-activated Killer(LAK)療法が奏功した肺転移を併った無色素性悪性黒色腫の一例, 日本口腔外科学会誌, 40巻, 7号, pp. 825-827, 19940401
  36. Circumvention of the resistance to cis platin by hyperthermia, Oral and Maxille-Facial Surgery, pp. 121-124, 19910401
  37. Adoptive immunotherapy of Oral cancer with lymphokine -activated killer (LAK) cells induced in newly developed serum -free medicem, Dentistry in Japan, 32巻, pp. 67-70, 19950401
  38. 抗EGF受容体抗体結合LAK細胞を用いた養子免疫療法の基礎的研究, Tissue Culture Res. Commun., 14巻, pp. 207-211, 19950401
  39. Differential expression of fibrob1st growth factor receptor (FGFR) -1-FGFR4 genes is associated with molignant progression in human salivary gland tumor, Oral Oncology, 2巻, pp. 316-319, 19950401
  40. Expression of Vascular Endothelial cell growth factor receptor in Normal and tumor cells, Oral Oncology, 2巻, pp. 320-324, 19950401
  41. Androgen -dependent expression of fibroblast growth factor -1 in submaxillary gland of mouse, Bichwm. Biophys. Res. Comm, 221巻, pp. 795-802, 19960401
  42. 口腔癌細胞の膜脂質組成の相違に基づく抗癌剤感受性, Tissue Culture Research Commun., 15巻, 147号, pp. 153, 19960401
  43. Expression of fibroblast growth factor binding protein HBp17 in normal and tumor cells, In vitro Cellular Developmental Biology, 32巻, pp. 69-71, 19960401
  44. 軟骨細胞分化のシグナリングメカニズム, CONNECTIVE TISSUE, pp. 印刷中, 19970401
  45. Immunohistochemical localization of fibroblast growth factor-1 (FGF-1) and FGF-2 in cultured human ameloblastoma epithelial cells and ameloblastona tissues, J Oral Pathol Med, 24巻, pp. 387-392, 19960401
  46. 下顎骨舌側に発生した大きな周辺性骨腫の一例, 広大歯誌, 28巻, pp. 264-266, 19960401
  47. Immunohistochemical study of over expression of fibroblast growth factor-1 (FGF-1), FGF-2 and FGF receptor-1 in human malignant salibary gland tissues, J. Pathology, 178号, pp. 429-436, 19960401
  48. Growth and Differentiation of human periodontal ligament-derived cells in serum-free defined culture, In vitro Cellular Developmental Biology, 33巻, pp. 302-309, 19970401
  49. Effect of insulin and transferrin on the generation of lymphokine -activated Killer cells in serum - free medium, Journal of Immunological Methods, 195巻, pp. 7-14, 19960401
  50. 顎関節症患者の症型分類による臨床統計的検討, 広大歯誌, 28巻, pp. 224-230, 19960401
  51. 複合ウィルス感染により頚部リンパ節腫腸をきたしたと思われた2例, 広大歯誌, 28巻, pp. 260-263, 19960401
  52. 癌細胞膜の脂質組成の差を利用した癌化学療法の基礎的研究, 日本癌治療学会誌, 31巻, pp. 1-7, 19960401
  53. Immunohistochemical localization of fibroblast growth factor(FGF)-1, FGF-2 and FGF receptor(FGFR-1) in pleomorphic adenoma of the salivary gland., J. Oral Pathology and Medicine, 26号, pp. 17-22, 19970401
  54. Characterization of a cartilage-derived 66-kDa protein(RGD-CAP/big-h3) that binds to collagen, Biochemica et Biophysica Acta, 1355巻, pp. 303-314, 19970401
  55. Function and testosterone dependency of fibroblast growth factor-1 in submaxillary gland of mouse, TISSUE CULTURE DENT. RES., 3巻, pp. 37-38, 19940401
  56. Local Signaling Mechanism of Chondrogenic Differentiation ; A role of FGF Signaling, J. CONNECTIVE TISSUE Res., 19970401
  57. ヒト唾液腺腫瘍の悪性転換過程におけるFGF受容体遺伝子群のディファレンシャル発現, 文部省科学研究費補助金によるがん重点研究報告集録, pp. 468-469, 19960401
  58. A Molecular Diagnosis of Crouzon Syndrome, 日本口腔外科学会雑誌, 26巻, pp. 208, 19970401
  59. Effects of hepatocytes growth factor (HGF) and activi NA on the morphogenesis of rat submandibular gland-derived epithelial cells in serum-free collagen gel culture, In vitro Cellular Developmental Biology, 19980401
  60. Molecular Diagnosis of human salivary gland tumors by Differential expression of fibroblast growth factor receptor genes, Tissue Culture Res. Communication, 16巻, pp. 207-212, 19970401
  61. A Study of Cellular Immunity in Head and Neck Cancer Patients, Int. J. Oral and Maxillofacial Surg., 26巻, pp. 222, 19970401
  62. Molecular Diagnosis and Gene therapy of Salivary gland tumors., Int. J. Oral and Maxillofacial Surg., 26巻, pp. 262, 19970401
  63. 三叉神経第3枝領域の知覚障害を初発症状とした海綿静脈洞原発悪性リンパ腫の一例, 日本口腔外科学会誌, 44巻, 12号, pp. 990-992, 19980401
  64. 表在性口腔癌の光線力学的療法, 広島大学歯学会雑誌, 30巻, 2号, pp. 240-242, 19981201
  65. ヒト唾液腺由来腺癌細胞へのKGF受容体遺伝子導入の影響, 日本口腔組織培養学会誌, 7巻, pp. 1, 19980401
  66. 口腔組織毛細血管における分泌型血管新生因子・受容体系の機能に及ぼす喫煙の影響, 平成10年度喫煙科学研究財団研究年報, pp. 167-172, 19980401
  67. Effect of photodynamic action with pheophorbide-a on human oral carcinoma cells in serum-free culture, Tissue Culture Research Communication, 18巻, pp. 345-352, 19990401
  68. Suppression of metastasis by tissue inhibitor of metallo-proteinase-1 in a newly established human oral Squamous cell carcinoma cell line, Int. J. Oncology, 16巻, pp. 119-124, 20000401
  69. Fibroblasts enhance the ability of oral Squamous cell carcinoma cell to activate MMP-2 by inducing the expression of membrane type-1 matrix metallo-proteinase, Cancer Letter, 20000401
  70. Nevoid basal cell carcinoma syndrome with a palmer epidermoid cyst and jaw cyst, British J Dermatology, 20000401
  71. Isoleucine prevents rat salivary gland epithelial cells from apoptosis in serum-free culture., In vitro Cellular Developmental Biology, 36巻, pp. 131-135, 20000401
  72. 嚢胞様病態を呈したWarthin腫瘍の1例, 広島大学歯学雑誌, 31巻, pp. 215-219, 19990401
  73. Effect of transforming growth factor B(TGF-B) on morphogenesis in rat salivary gland-derived RSMG-1 cells., Tissue Culture Research Communication, 18巻, pp. 339-343, 19990401
  74. Isolation and serum-free culture of epithelial cells derived from Epithelial rest of Molasses in periodontal Ligament., In vitro Cellular Developmental Biology, 36巻, pp. 287-289, 20000401
  75. FGF結合蛋白を標的とした扁平上皮癌の分子標的治療, 文部省科学研究費補助金=がん特定研究報告集録, pp. 712-713, 19990401
  76. 口腔組織毛細血管における分泌型血管増殖因子受容体の機能に及ぼす喫煙の影響, 平成10年度喫煙科学研究財団研究年報, pp. 195-200, 20000401
  77. 静脈異形成症の遺伝子診断, 治療学, 34巻, 4号, pp. 95-99, 20000401
  78. Activin A induces expression of rat sel-IL mRNA, anegative regulator of notch signaling, in rat salivary gland-derived epithelial cells., Biochemical and Biophysical Research Communication, 282巻, pp. 745-749, 20010401
  79. Human fibroblast growth factor-binding protein HBp17 enhances the tumorigenic potential of immortalized squamous epithelial cells, Cytotechnology, 20010401
  80. Ex vivoにおける野生型KGF受容体遺伝子導入による唾液腺癌の分化およびアポトーシス, 口腔組織培養学会誌, 9巻, 1号, pp. 69-70, 20000401
  81. 口腔由来正常上皮細胞および扁平上皮癌細胞株におけるpatched遺伝子の発現と機能解析, 口腔組織培養学会誌, 9巻, 1号, pp. 71-72, 20000401
  82. Mutation in the human homologue of the Drosophila segment polarity gene Patched in Oral squamous cell carcinoma cell lines., In Vitro Cellular of Developmental Biology, 37巻, pp. 10, 20010401
  83. Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis, Proceedings of National Academy of Sciences= USA, 20010401
  84. 口腔癌の自己増殖促進因子及び血管新生因子遺伝子を標的とした遺伝子診断・治療の研究, 平成11-12年度科学研究費補助金基盤研究B(2)報告書, pp. 3月, 20010401
  85. FGF受容体遺伝子を標的としたヒト唾液腺腫瘍の遺伝子診断・治療法の開発研究, 平成11-12年度科学研究費補助金基盤研究B(2)報告書, pp. 3月, 20010401
  86. 唾液中のストレス応答蛋白の分泌に及ぼす喫煙の効果に関する研究, 平成10年度喫煙科学研究財団研究年報, pp. 6月, 20010401
  87. Molecular Diagnosis of Venous Malformations(VMs)Molecular understandings of genotype/phenotype correlations in the VMs, The 13th Naito Conference on Molecular Biological Approaches for Intractable Diseases[(]G0002[)], 11巻, pp. 102, 20000401
  88. 口腔・顎・顔面領域における静脈奇形(Vascular Malformations : VMs)の遺伝子診断システムを第二軍医大学に構築するための共同研究, 日中医学, 16巻, 2号, pp. 34, 20010201
  89. 遺伝子が語る口腔の病気(疾患), 広島大学放送公開講座テキスト口は健康のバロメーター, pp. 62-73, 20010401
  90. セミパラチンスク核実験場周辺住民における顎・顔面・口腔疾患の実態調査, 広島国際シンポジウム「旧ソ連における国際学術協力の成果と問題点, 20000401
  91. Expression and function of Sonic hedgehog and patched gene in Oral epithelial cells and Oral squamous cell carcinoma cell lines, In Vitro Cellular & Developmental Biology, 36巻, 3号, pp. 50, 20000401
  92. Wild-type FGFR2-(]G0003[)b/KGFR gene inhibits growth and induces differentiation/apoptosis in salivary gland tumors in nitre and in Vivo, In Vitro Cellular & Developmental Biology, 36巻, 3号, pp. 27, 20000401
  93. Activin A Induces Expression of Rat Sel-IL mRNA, a Negative Regulator of Notch Signaling, in Rat Salivary Gland-Derived Epithelial Cells, 生化的生物物理学的研究報告集, 282巻, 3号, pp. 745-749, 20010401
  94. 口腔癌細胞の脂質組成の相違に基づく抗癌剤感受性, Tiss. Cult. Res. Commun, 15巻, pp. 147-153, 19960401
  95. 癌細胞膜の脂質組成の差を利用した癌化学療法の基礎的研究, 日癌治療誌, 31巻, 7号, pp. 413-419, 19960401
  96. Lymphokine-activated killer (LAK) 療法が奏功した肺転移を伴った無色素性悪性黒色腫の1例, 日口外誌, 40巻, 7号, pp. 825-827, 19940401
  97. 広島の原爆被爆者甲状腺細胞にみられた微小核-放射線による影響か。セミパラチンスクの症例も加えて-, 広島医学, 55巻, 3号, pp. 108-201, 20020401
  98. Expression of fibroblast growth factor (FGF) receptor genes in human hepatoma-derived cell lines., In vitro Cellular Developmental Biology, 39巻, 7号, pp. 321-328, 20031101
  99. Three New Cytotoxic Acylspermidines from a Soft Coral, Sinularia sp., Biosci. Biotechnol. Biochem., 67巻, 6号, pp. 1410-1412, 20030401
  100. Role of stromal thrombospondin-1 in motility and proteolytic activity of oral squamous cell carcinoma cells, Intern. J. Molecular Medicine= 14= xxxx (2005)= in press., 12巻, pp. 447-452, 20030401
  101. Participation of fibroblasts in MMP-2 binding and activation on the surface of oral squamous cell carcinoma cells., Int J Oncol, 22巻, 3号, pp. 657-662, 20030401
  102. Introduction of wild-type patched gene suppresses the oncogenic potential of human squamous cell carcinoma cell lines including A431., Oncogene, 21巻, pp. 2670-2678, 20020401
  103. Nuclear localization of Duplin, a b-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway., J Biological Chemistry, 22巻, 277号, pp. 5816-5822, 20020401
  104. 静脈異形成症例の遺伝子診断, 治療学, 34巻, 4号, pp. 441-445, 20000401
  105. ヒト唾液腺由来上皮細胞におけるアンジポエチンとその受容体Tie-2の発現, 口腔組織培養学会誌, 11巻, 1号, pp. 47-48, 20020301
  106. 静脈奇形におけるEndothelial cell specific tyrosine kinase receptor Tie-2の機能解析, 口腔組織培養学会誌, 10巻, 1号, pp. 47-48, 20010301
  107. EGFRをターゲットとした扁平上皮癌の分子標的治療, 口腔組織培養学会誌, 11巻, 1号, pp. 67-68, 20020301
  108. 変異型Tie2遺伝子導入による血管腫モデルの作成, 口腔組織培養学会誌, 12巻, 1号, pp. 35-36, 20030301
  109. 野生型遺伝子導入による扁平上皮癌細胞の増殖制御, 口腔組織培養学会誌, 12巻, 1号, pp. 41-42, 20030301
  110. Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis., The Second Japan-China Joint Conference for Cancer Research, pp. 23, 20020501
  111. Wntシグナル伝達経路の制御機構, Tissue Culture Research Commun., 21巻, pp. 83-92, 20020401
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  156. Vascular endothelial growth factor induces the disorganization of actin stress fibers accompanied by protein tyrosine phosphorylation and morphological change in Balb/C3T3 cells., Biochem Biophys Res Commun, 202巻, 3号, pp. 1716-23, 19940801
  157. Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites., Proc Natle Acad Sci, 88巻, 13号, pp. 5819-23, 19910701
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  161. 著明な脂肪化を伴った頬部血管平滑筋腫の1例., 日口外誌, 54巻, pp. 621-625, 20081201
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  170. マウス軟骨前駆細胞株ATDC5の増殖分化とFGFシグナル伝達の役割 : Gene Transfer による Dominant Negative FGFR1 の発現, 日本骨代謝学会雑誌, 14巻, 2号, pp. 60, 19960101
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  172. 放射線療法とレチノイド投与後に骨様組織を形成した巨大な腺癌(NOS)の1例., 日口外誌, 54巻, pp. 698-702, 20081201
  173. Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway, JOURNAL OF BIOLOGICAL CHEMISTRY, 277巻, 8号, pp. 5816-5822, FEB 22 2002
  174. Activin-like signaling activates Notch signaling during mesodermal induction, INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 48巻, 4号, pp. 327-332, JUN 2004
  175. Zooxanthellactone, a novel gamma-lactone-type oxylipine from dinoflagellates of Symbiodinium sp.: Structure, distribution, and biological activity, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 68巻, 4号, pp. 848-852, APR 2004
  176. Induction of tooth and eye by transplantation of activin A-treated, undifferentiated presumptive ectodermal Xenopus cells into the abdomen, INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 48巻, 10号, pp. 1105-1112, DEC 2004
  177. Modulation of activin A-induced differentiation in vitro by vascular endothelial growth factor in Xenopus presumptive ectodermal cells, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 41巻, 3-4号, pp. 104-110, MAR-APR 2005
  178. Plasminogen activator/plasmin system suppresses cell-cell adhesion of oral squamous cell carcinoma cells via proteolysis of E-cadherin, INTERNATIONAL JOURNAL OF ONCOLOGY, 27巻, 3号, pp. 693-698, SEP 2005
  179. Radiation dose estimation by tooth enamel EPR dosimetry for residents of Dolon and Bodene, JOURNAL OF RADIATION RESEARCH, 47巻, pp. A47-A53, FEB 2006
  180. Spongolactams, farnesyl transferase inhibitors from a marine sponge: Isolation through an LC/MS-Guided assay, structures, and semisyntheses, JOURNAL OF ORGANIC CHEMISTRY, 72巻, 19号, pp. 7190-7198, SEP 14 2007
  181. Induction of alpha 2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion, ONCOLOGY REPORTS, 17巻, 2号, pp. 417-423, FEB 2007
  182. ESR dosimetry study on population of settlements nearby Ust-Kamenogorsk city, Kazakhstan, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 48巻, 4号, pp. 419-425, NOV 2009
  183. Cyclolobatriene, a novel prenylated germacrene diterpene, from the soft coral Lobophytum pauciflorum, BIOORGANIC & MEDICINAL CHEMISTRY, 20巻, 2号, pp. 687-692, JAN 15 2012
  184. Novel Cytotoxic Polyoxygenated Steroids from an Okinawan Sponge Dysidea sp., BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 76巻, 5号, pp. 999-1002, MAY 2012
  185. Ectomesenchymal chondromyxoid tumor of the tongue: insights on histogenesis, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 115巻, 2号, pp. 233-240, FEB 2013
  186. Ameloblastic Carcinoma, Secondary Type, of the Mandible: A Case Report, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 71巻, 1号, pp. E58-E62, JAN 2013
  187. Petrosiols A-E, neurotrophic diyne tetraols isolated from the Okinawan sponge Petrosia strongylata, TETRAHEDRON, 69巻, 1号, pp. 101-106, JAN 7 2013
  188. 1 alpha,25(OH)2D3 down-regulates HBp17/FGFBP-1 expression via NF-kappa B pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 136巻, pp. 98-101, JUL 2013
  189. Long-term serial cultivation of mouse induced pluripotent stem cells in serum-free and feeder-free defined medium, INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 57巻, 9-10号, pp. 715-724, 2013
  190. Biomedical advances from tissue culture, CYTOTECHNOLOGY, 65巻, 6号, pp. 967-971, DEC 2013
  191. Generation of Human Induced Pluripotent Stem (Ips) Cells in Serum- and Feeder-Free Defined Culture and TGF-B1 Regulation of Pluripotency, PLOS ONE, 9巻, 1号, JAN 29 2014
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  193. Overexpression of integrin alpha v facilitates proliferation and invasion of oral squamous cell carcinoma cells via MEK/ERK signaling pathway that is activated by interaction of integrin alpha v beta 8 with type I collagen, INTERNATIONAL JOURNAL OF ONCOLOGY, 45巻, 5号, pp. 1875-1882, NOV 2014
  194. Comparison of the prognosis of bisphosphonate-related osteonecrosis of the jaw caused by oral and intravenous bisphosphonates, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44巻, 7号, pp. 840-844, JUL 2015
  195. Generation of cleidocranial dysplasia-specific human induced pluripotent stem cells in completely serum-, feeder-, and integration-free culture, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 52巻, 2号, pp. 252-264, FEB 2016
  196. Bisphosphonate-related osteonecrosis of the jaw successfully treated with surgical resection and its histopathological features: A long-term follow-up report, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 27巻, 2号, pp. 283-286, MAR 2015
  197. Photodynamic therapy using Photofrin and excimer dye laser treatment for superficial oral squamous cell carcinomas with long-term follow up, PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 14巻, pp. 104-110, JUN 2016
  198. Eldecalcitol (ED-71), an analog of 1 alpha,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 164巻, pp. 79-84, NOV 2016
  199. Eldecalcitol (ED-71), an analog of 1 alpha,25(OH)(2)D-3, inhibits the growth of squamous cell carcinoma (SCC) cells in vitro and in vivo by down-regulating expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) and FGF-2, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 53巻, 9号, pp. 810-817, OCT 2017
  200. Weekly paclitaxel plus cetuximab reduces the lung metastasis of adenoid cystic carcinoma arising from the salivary gland, ORAL SCIENCE INTERNATIONAL, 12巻, 2号, pp. 67-71, MAY 2015
  201. New Crambescidin-Type Alkaloids from the Indonesian Marine Sponge Clathria bulbotoxa, MARINE DRUGS, 16巻, 3号, MAR 2018
  202. Suture granulomas developing after the treatment of oral squamous cell carcinoma, INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 50巻, pp. 68-71, 2018

受賞

  1. 2012年06月05日, The Society for In Vitro Biology(SIVB) 2012 Fellow Award, William J. Smith, President, Society for In Vitro Biology
  2. 2013年11月24日, 日本口腔組織培養学会学会賞, 日本口腔組織培養学会会長
  3. 2004年03月, カザフスタン共和国保健功労勲章, カザフスタン共和国厚生大臣
  4. 2015年05月27日, 日本組織培養学会功労賞, 日本組織培養学会会長