稲葉 俊哉Toshiya Inaba

Last Updated :2017/11/01

所属・職名
原爆放射線医科学研究所 ゲノム障害医学研究センター 教授
メールアドレス
tinabahiroshima-u.ac.jp

基本情報

学位

  • 博士(医学) (東京大学)

研究分野

  • 医歯薬学 / 基礎医学 / 医化学一般
  • 医歯薬学 / 内科系臨床医学 / 血液内科学

研究キーワード

  • 細胞周期
  • 白血病
  • アポトーシス

教育活動

授業担当

  1. 2017年, 学部専門, セメスター(前期), 放射線生物学・放射線健康リスク科学
  2. 2017年, 学部専門, 集中, 医学研究実習
  3. 2017年, 博士課程・博士課程後期, セメスター(前期), 放射線統合医科学
  4. 2017年, 博士課程・博士課程後期, セメスター(前期), 放射線統合医科学
  5. 2017年, 博士課程・博士課程後期, セメスター(前期), 放射線統合医科学
  6. 2017年, 博士課程・博士課程後期, セメスター(前期), 放射線統合医科学
  7. 2017年, 修士課程・博士課程前期, セメスター(前期), 医歯科学演習(がん分子病態学)
  8. 2017年, 修士課程・博士課程前期, セメスター(後期), 医歯科学演習(がん分子病態学)
  9. 2017年, 修士課程・博士課程前期, セメスター(前期), 医歯科学特別研究(がん分子病態学)
  10. 2017年, 修士課程・博士課程前期, セメスター(後期), 医歯科学特別研究(がん分子病態学)
  11. 2017年, 修士課程・博士課程前期, セメスター(前期), 分子生物学と放射線防護
  12. 2017年, 博士課程・博士課程後期, セメスター(前期), がん分子病態学特別演習
  13. 2017年, 博士課程・博士課程後期, セメスター(後期), がん分子病態学特別演習
  14. 2017年, 博士課程・博士課程後期, セメスター(前期), がん分子病態学特別実験
  15. 2017年, 博士課程・博士課程後期, セメスター(後期), がん分子病態学特別実験

研究活動

学術論文(★は代表的な論文)

  1. Poly-ADP Ribosylation of Miki by tankyrase-1 Promotes Centrosome Maturation, MOLECULAR CELL, 47巻, 5号, pp.694-pp.706, SEP 14 2012
  2. Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors, LEUKEMIA, 26巻, 12号, pp.2483-pp.2493, DEC 2012
  3. Identification of the integrin beta 3 L718P mutation in a pedigree with autosomal dominant thrombocytopenia with anisocytosis, BRITISH JOURNAL OF HAEMATOLOGY, 160巻, 4号, pp.521-pp.529, FEB 2013
  4. Reversal of Apoptosis by the leukemia-associated E2A-HLF Chimeric transcription factor, Nature, 382巻, pp.541, 19960401
  5. Fusion of the leucine zipper gene HLF, to the EZA gene in human acute β-lineage leukemia, Science, 257巻, pp.531, 19920401
  6. DNA binding specificity and trans-activating potential of the leukemia-associated E2A-HLF fusion protein, Molecular and Cellular Biology, 14巻, pp.3403, 19940401
  7. Genomic organization, chromosome localization, and independent expression of human cyclin D genes., Genomics, 13巻, pp.565-pp.574, 19920401
  8. Functional and molecular characteristics of acute lymphoblastic leukemia cells with a mature T-cell phenotype from a patient with ataxia telangiectasia., Leukemia, 5巻, pp.88-pp.89, 19920401
  9. Molecular analysis of bcr/abl products in a case of myelodysplastic syndrome with late appearing Philadelphia chromosome., Br J Haematol, 78巻, pp.130-pp.132, 19910401
  10. Clonal analysis of transient myeloproliferative disorder in Down’s syndrome., Leukemia, 5巻, pp.56-pp.59, 19910401
  11. Characterization of an embryonal rhabdomyosarcoma cell line showing amplification and over-expression of the N-myc oncogene., Int J Cancer, pp.705-pp.711, 19900401
  12. Karyotypic patterns of acute mixed lineage leukemia., Leukemia, 4巻, pp.121-pp.126, 19900401
  13. Ph1染色体陽性bcr再構成陽性の巨核芽球性白血病へ移行した小児骨髄異形成症候群(RAEBt)の1例, 31巻, pp.994-pp.998, 19900401
  14. Heterogeneity in the breakpoints of chromosome 19 among acute leukemic patients with the t(11;19)(q23;p13) tranlocation., Am. J. Hematol. =, 31巻, pp.253-pp.257, 19890401
  15. Fatal infectious mononucleosis with staphylococcal pyoderma in a girl with hereditary immunological dysregulations., Eur J Pediatr, 149巻, pp.177-pp.178, 19890401
  16. Chronic myelomonocytic leukemia with chromosomal changes involving 1p36 and hepatocellular carcinoma in a case of Fanconi’s anemia., Eur J Haematol, 42巻, pp.492-pp.495, 19890401
  17. Similar chromosomal patterns and lack of N-myc gene amplification localized and IV-S stage neuroblastoma in infants., Med. Pedatr. Oncol., 17巻, pp.111-pp.115, 19890401
  18. Cytogenetic findings and prognosis in neuroblastoma with emphasis on marker chromosome 1., Cancer, 63巻, pp.126-pp.132, 19890401
  19. 鑑別診断 小児疾患の鑑別の要点 7 染色体異常と悪性腫瘍(総説), 42巻, pp.3008-pp.3009, 19890401
  20. T細胞系から骨髄系に表現型の変化がみられた急性白血病の1例, 30巻, pp.2163-pp.2168, 19890401
  21. 染色体異常を有するsideroblastic anemiaで発症し、acutemyelomonocytic leukemiaに移行した1症例, 3巻, pp.361-pp.366, 19890401
  22. The e2a-hlf oncoprotein activates groucho-related genes and suppresses runx1., Mol. Cell. Biol., 21巻, pp.5935-pp.5945, 20010401
  23. Erythropoietin regulates vascular smooth muscle cell apoptosis by a phosphatidylinositol 3 kinase-dependent pathway., Kidney Int., 58巻, pp.269-pp.282, 20000401
  24. Involvement of mTOR/Bim, not Akt/Bad pathway in cytokine-mediated cells survival signaling downstream of PI3-kinase in murine hematopoietic progenitors., Blood 96 Suppl., 1巻, pp.568A, 20000401
  25. Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest and development of acute lymphoblastic leukemia., Blood, 93巻, pp.2780-pp.2790, 19990401
  26. Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3(E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes., Mol. Cell. Biol., 19巻, pp.2754-pp.2762, 19990401
  27. SLUG, a ces-1-related zinc-finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein., Mol. Cell, 4巻, pp.343-pp.352, 19990401
  28. Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice., Brain Res., 820巻, pp.1-pp.11, 19990401
  29. Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation., Oncogene, 18巻, pp.165-pp.172, 19990401
  30. Two candidate downstream target genes for E2A-HLF., Blood, 93巻, pp.321-pp.332, 19990401
  31. Essential role of the BH3 factor, Bim, in the cytokine-mediated apoptosis program: Implications in the antiapoptotic Ras pathways and in leukemogenesis., Blood 94 Suppl., 1巻, pp.688A, 19990401
  32. Thyrotroph embryonic factor is a possible regulatory factor maintaining the quiscent hematopoietic progenitors., Blood 94 Suppl., 1巻, pp.271A, 19990401
  33. The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the E2A-HLF chimeric oncoprotein., Mol. Cell. Biol., 18巻, pp.6035-pp.6043, 19980401
  34. Transcription factor NF-E2 is essential for the polyploidization of a human megakaryoblastic cell line, Meg-J., Biochem. Biophys. Res. Commun., 247巻, pp.65-pp.69, 19980401
  35. Involvement of Bim, the BH3-containing cell death activator, in cytokine-mediated apoptosis program and in leukemogenesis by the E2A-HLF chimera, Blood 92 Suppl., 1巻, pp.199A, 19980401
  36. Identification of the antiapoptotic zinc-finger transcription factor SLUG as a target of E2A-HLF oncogenic fusion protein., Blood 92 Suppl., 1巻, pp.479A, 19980401
  37. Groucho-related genes are activated by the E2A-HLF chimeric oncoprotein In FL5.12 cells., Blood 92 Suppl., 1巻, pp.589A, 19980401
  38. Downstream target genes for E2A-HLF Identified by cDNA microarray analysis., Blood 92 Suppl., 1巻, pp.590A, 19980401
  39. Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells., Blood, 90巻, pp.3884-pp.3892, 19970401
  40. Pivotal role for the NFIL3/E4BP4 transcription factor in IL-3-mediated survival of pro-B lymphocytes., Proc. Natl. Acad. Sci. USA, 94巻, pp.2609-pp.2614, 19970401
  41. Cell transformation mediated by homodimeric E2A-HLF transcription factors., Mol. Cell. Biology, 17巻, pp.1417-pp.1424, 19970401
  42. Ras-dependent and -independent regulation of E4BP4/NFIL3 transcription factor in cytokine-mediated cell survival of pro-B lymphocytes: the target gene program for oncogenic Ras, Bcr-Abl and E2A-HLF chimeras in leukemogenesis., Blood 90 Suppl., 1巻, pp.47A, 19970401
  43. Thyrotroph embryonic factor (TEF) is capable of regulating the cell cycle and cell survival of lymphoid cells., Blood 90 Suppl., 1巻, pp.138A, 19970401
  44. Anti-apoptotic effects of E2A-HLF: Evidence for mechanisms involving both gain and loss of function., Blood 88(10) Supple., 1巻, 10号, pp.552A, 19960401
  45. E4BP4, an IL-3-responsive bZIP transcription factor, contributes to cell survival in mouse pro-B cells., Blood 88(10) Supple., 1巻, 10号, pp.658A, 19960401
  46. E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF., Mol. Cell. Biology, 15巻, pp.3247-pp.3255, 19950401
  47. The E2A-HLF fusion protein as a direct hmodimeric trans-activator of downstream target genes in malignant transformation., abstr. Blood 86(10) Supple., 1巻, 10号, pp.39A, 19950401
  48. The oncogenc E2A-HLF fusion protein protects leukemic B-precursor cells from apotosis., abstr. Blood 86(10) Supple., 1巻, 10号, pp.327A, 19950401
  49. Chromosomal localization and cDNA cloning of the human DBP and TEF genes., Genomics, 23巻, pp.344-pp.351, 19940401
  50. Differential molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia., Blood, 79巻, pp.1781-pp.1785, 19920401
  51. Differential expression of myogenic regulatory genes, MyoD1 and myogenin, in human rhabdomyosarcoma sublines., Int J Cancer, 50巻, pp.977-pp.983, 19920401
  52. Ara-C大量(+VP16大量)+TBIの前処置による同種骨髄移植, 93巻, pp.1860-pp.1866, 19890401
  53. 骨髄に好酸球、好塩基球の増殖を認め、CD19(B4)抗原の発現がみられた急性骨髄単球性白血病(M4)の1例, 30巻, pp.726-pp.730, 19890401
  54. 新生児期にTAMと肝障害を伴ったダウン症候群児の1症例, 21巻, pp.927-pp.938, 19890401
  55. 未分化横紋筋肉腫細胞株SCMC-MM-1-SCの分化誘導, 149巻, pp.727-pp.728, 19890401
  56. 小児悪性脳腫瘍に対するBM rescue を併用したCyclophosphamide+Etoposideの大量化学療法, 16巻, pp.263-pp.268, 19890401
  57. 同種骨髄移植後慢性肺疾患を呈した1例, 3巻, pp.78-pp.82, 19890401
  58. 難治性小児急性白血病に対するmitoxantrone単独投与の効果, 3巻, pp.55-pp.59, 19890401
  59. Childhood myelodysplastic syndromes with 11p15 translocation., Cancer Genet.Cytogenet., 34巻, pp.41-pp.46, 19880401
  60. Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorders in Down’s syndrome., Blood, 72巻, pp.15-pp.23, 19880401
  61. Chromosome findings and prognosis in 15 patients with neuroblastoma found by VMA mass screening., J. Pediatr., 112巻, pp.567-pp.571, 19880401
  62. Translocation 2;8 in a congenital rhabdomyosarcoma., Cancer Genet.Cytogenet., 30巻, pp.343-pp.345, 19880401
  63. 同種骨髄移植後アデノウイルス11型による遅発性出血性膀胱炎の経過の後に尿管狭窄を呈した2例, 29巻, pp.2379-pp.2383, 19880401
  64. シスプラチンを使用した悪性固形腫瘍症例の腎機能の長期予後の検討, 5巻, pp.119-pp.123, 19880401
  65. 2年以上経過した小児ANLL8例の臨床的検討, 23巻, pp.990-pp.992, 19880401
  66. 初診時より骨髄転移があり、N-mycの増幅が認められた年長児横紋筋肉腫の1剖検例, 92巻, pp.1805-pp.1808, 19880401
  67. 骨髄にhistiocyteの増殖を認め、汎血球減少を伴った亜急性壊死性リンパ節炎の1例, 29巻, pp.1120-pp.1124, 19880401
  68. 著名な肝機能異常とDICを呈した小児細網症の1例, 22巻, pp.1178-pp.1181, 19880401
  69. 重度精神運動発達遅延、心奇形、Sotos症候群様の顔貌を有した男児に発症した肝芽細胞腫の1例, 51巻, pp.1282, 19880401
  70. inv(11)(p15q23)の染色体異常が認められた小児骨髄異形成症候群(MDS)の1例, 29巻, pp.189-pp.194, 19880401
  71. 同種骨髄移植が奏功した再生不良性貧血の頻回輸血例, 4巻, pp.150-pp.153, 19870401
  72. 血液疾患ならびに悪性腫瘍患児の風疹感染と風疹ワクチン接種, 4巻, pp.121-pp.124, 19870401
  73. 著名な肝機能障害とDICを呈したVirus-associated hemophagocytic syndromeの3例, 4巻, pp.10-pp.13, 19870401
  74. 寛解中多発性脾膿瘍をきたし、脾摘により感染の軽快をみた急性前骨髄性白血病(FAB M3)の1例, 22巻, pp.778-pp.781, 19870401
  75. Down症候群に発生した白血病とtransient abnormal myelopoiesis(TAM)の染色体所見と臨床像, 91巻, pp.2995-pp.3002, 19870401
  76. 小児SLEにおけるT細胞サブセットの形質表現に関する検討, 91巻, pp.1611-pp.1614, 19870401
  77. 子宮内感染症により胎児切迫仮死を呈したリステリア菌による新生児敗血症髄膜炎の1治癒例, 17巻, pp.437-pp.440, 19870401
  78. Cis-dichlorodiammineplatiniumを含む多剤併用療法による神経芽腫の治療 ー効果および副作用ー, 1巻, pp.1116-pp.1121, 19840401
  79. リンパ球の腫瘍化をきたす遺伝子の異常, pp.1752-pp.1755, 19960401
  80. サイトカインによる生存維持シグナル サイトカインの新たな機能と生命現象, pp.2040-pp.2044, 20000401
  81. Wilms腫瘍 -染色体所見と発癌機序-, pp.171-pp.178, 19890401
  82. ヒト白血病細胞よりクローニングされたロイシンジッパー構造を持つ新しい転写調節因子、HLF, pp.812-pp.814, 19930401
  83. common ALLの発癌機序を考える?線虫と白血病を結ぶもの, pp.335-pp.343, 19960401
  84. アポトーシス制御転写調節システムと白血病, pp.891-pp.895, 19970401
  85. 造血前駆細胞のアポトーシスとBH3因子(総説), pp.281-pp.287, 20000401
  86. ドミナント・ネガティブ蛋白を用いた癌原性融合転写因子機能の抑制, pp.189-pp.194, 19970401
  87. アポトーシス決定機構と急性白血病, pp.486-pp.490, 19970401
  88. E2A転写因子と急性リンパ性白血病, pp.461-pp.467, 20000401
  89. 造血細胞とアポトーシス, pp.232-pp.240, 19980401
  90. E2Aとリンパ性白血病, pp.130-pp.155, 20010401
  91. リンパ球分化過程のアポトーシス制御, pp.315-pp.322, 20010401
  92. E2Aキメラ転写因子とALLの分子発癌機序, pp.361-pp.366, 19990401
  93. 17;19転座型ALLとアポトーシス, pp.223-pp.231, 19970401
  94. 鑑別診断 小児疾患の鑑別の要点 7 染色体異常と悪性腫瘍, pp.3008-pp.3009, 19890401
  95. 被曝後造血器腫瘍とAML1転写因子, 放射線生物研究, 37巻, 3号, pp.251-pp.263, 20020401
  96. AML1点変異をもつ骨髄異形成症候群(MDS)の多段階発症機構, 広島医学, 59巻, 4号, pp.379-pp.382, 20060401
  97. AML1/RUNX1の点突然変異は骨髄異形成症候群(MDS)に高頻度に認められる, 長崎医学会雑誌, 79巻, Suppl号, pp.206-pp.211, 20040901
  98. AMLに対するイマチニブ治療の可能性, 血液・腫瘍科, 50巻, 3号, pp.326-pp.331, 20050301
  99. 放射線誘発白血病に多発する7q欠失領域からの責任遺伝子候補単離, 長崎医学会雑誌, 81巻, pp.358-pp.362, 20060901
  100. AML/MDS発症における-7/7q-異常, 血液・腫瘍科, 54巻, 4号, pp.448-pp.453, 20070401
  101. Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator, Gene Therapy, 10巻, 5号, pp.375-pp.385, 20030301
  102. Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors., Mol. Cell. Biol., 21巻, pp.854-pp.864, 20010501
  103. The expression of Bcl-2 family proteins (Bcl-2, Bcl-x, Bax, Bak and Bim) in human lymphocytes., Immunol Lett, 81巻, pp.107-pp.113, 20020501
  104. Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome / acute myeloid leukemia., Blood, 101巻, pp.673-pp.680, 20030501
  105. Regulation of osteoclast apoptosis by ubiqutination of proapoptotic BH3-only Bcl-2 family member Bim., EMBO J., 22巻, pp.6653-pp.6664, 20030501
  106. High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia., Blood, 103巻, pp.2316-pp.2324, 20041001
  107. Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein., Blood, 103巻, pp.3185-pp.3191, 20041001
  108. Deletion 6p23 and add(11)(p15) leading to NUP98 translocation in a case of therapy-related atypical chronic myelocytic leukemia transforming to acute myelocytic leukemia., Cancer Genet. Cytogenet., 152巻, pp.56-pp.60, 20041001
  109. The Adenovirus E1A and E1B19K genes provide a helper function for transfection-based AAV vector production., J. Gen.Virol., 85巻, pp.2009-pp.2014, 20041001
  110. TEF, an anti-apoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by downregulating expression of the common b chain of cytokine receptors., Blood, 105巻, pp.4437-pp.4444, 20051001
  111. Structure of the human Bim gene and its transcriptional regulation in Baf-3, interleukin-3-dependent hematopoietic cells., Mol. Biol. Rep., 32巻, pp.79-pp.85, 20051001
  112. Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells., Brain Res., 1050巻, pp.15-pp.26, 20051001
  113. Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations., Leukemia, 20巻, pp.635-pp.644, 20061001
  114. Cytokines direct the regulation of Bim mRNA stability by Heat shock cognate protein 70., Mol. Cell, 25巻, pp.99-pp.112, 20071001
  115. Hypercalcemia in childhood acute lymphoblastic leukemia:frequent implication of PTHrP and E2A-HLF from translocation 17;19., Leukemia, 21巻, pp.288-pp.296, 20071001
  116. Hyperactivation of the RAS signaling pathway in myelodysplastic syndromewith AML1/RUNX1 point mutations., Leukemia, 20巻, pp.635-pp.644, 20061001
  117. シャペロン蛋白質によるmRNA安定性制御メカニズム, 医学のあゆみ, 221巻, 12号, pp.1007-pp.1008, 20071001
  118. サイトカインによるmRNA安定性調節機構 -造血細胞のアポトーシスと白血病への関与-, 臨床血液, 47巻, 3号, pp.190-pp.195, 20061001
  119. 病態生理に関する基礎的・臨床的研究 最近の進歩 病態研究 Bimと白血病分子標的 サイトカイン依存性アポトーシスのキープレーヤー, 医学のあゆみ 別冊血液疾患state of arts, 3巻, 別冊号, pp.244-pp.247, 20051001
  120. Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors, MOLECULAR AND CELLULAR BIOLOGY, 21巻, 3号, pp.854-pp.864, FEB 2001
  121. Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBP alpha gene, GENES CHROMOSOMES & CANCER, 36巻, 2号, pp.167-pp.174, FEB 2003
  122. Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia, BLOOD, 101巻, 2号, pp.673-pp.680, JAN 15 2003
  123. Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator, GENE THERAPY, 10巻, 5号, pp.375-pp.385, MAR 2003
  124. Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim, EMBO JOURNAL, 22巻, 24号, pp.6653-pp.6664, DEC 15 2003
  125. High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia, BLOOD, 103巻, 6号, pp.2316-pp.2324, MAR 15 2004
  126. Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein, BLOOD, 103巻, 8号, pp.3185-pp.3191, APR 15 2004
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  147. Rapid Emergence of Telaprevir Resistant Hepatitis C Virus Strain from Wildtype Clone In Vivo, HEPATOLOGY, 54巻, 3号, pp.781-pp.788, SEP 2011
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  158. Ultradeep Sequencing Study of Chronic Hepatitis C Virus Genotype 1 Infection in Patients Treated with Daclatasvir, Peginterferon, and Ribavirin, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58巻, 4号, pp.2105-pp.2112, APR 2014
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