細井 徹Toru Hosoi

Last Updated :2017/09/04

所属・職名
大学院医歯薬保健学研究科(薬) 薬学講座 准教授
メールアドレス
toruhhiroshima-u.ac.jp

基本情報

学位

  • 博士(薬学) (北海道大学)
  • 修士(薬学) (北海道大学)

研究分野

  • 医歯薬学 / 薬学 / 薬理系薬学

研究キーワード

  • 神経変性疾患
  • 肥満
  • 小胞体ストレス

教育活動

授業担当

  1. 2017年, 教養教育, 1ターム, 初修生物学(受講場所:東広島キャンパス)
  2. 2017年, 教養教育, 1ターム, 初修生物学(受講場所:霞キャンパス)[1医,1歯,1薬]
  3. 2017年, 学部専門, 1ターム, 臨床薬物治療学A
  4. 2017年, 学部専門, 3ターム, 臨床薬理学A
  5. 2017年, 博士課程・博士課程後期, セメスター(後期), バイオメディカルサイエンスの創生展開
  6. 2017年, 博士課程・博士課程後期, セメスター(後期), バイオメディカルサイエンスの創生展開
  7. 2017年, 修士課程・博士課程前期, セメスター(前期), 分子治療薬効学特論演習
  8. 2017年, 修士課程・博士課程前期, セメスター(後期), 分子治療薬効学特論演習
  9. 2017年, 博士課程・博士課程後期, セメスター(前期), 治療薬効学特別演習
  10. 2017年, 博士課程・博士課程後期, セメスター(後期), 治療薬効学特別演習
  11. 2017年, 博士課程・博士課程後期, セメスター(前期), 治療薬効学特別実験
  12. 2017年, 博士課程・博士課程後期, セメスター(後期), 治療薬効学特別実験

研究活動

学術論文(★は代表的な論文)

  1. Expression of leptin receptors and induction of IL-1beta transcript in glial cells., Biochem. Biophys. Res. Commun., 273巻, 1号, pp.312-pp.315, 20000601
  2. Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis., Am. J. Physiol., 279巻, 1号, pp.R141-R147, 20000701
  3. Subdiaphragmatic vagotomy fails to inhibit intravenous leptin-induced IL-1beta expression in the hypothalamus., Am. J. Physiol., 282巻, 2号, pp.R627-R631, 20020201
  4. Leptin induces IL-1 receptor antagonist expression in the brain., Biochem. Biophys. Res. Commun., 294巻, 2号, pp.215-pp.219, 20020601
  5. ★, Brain stem is a direct target for leptin’s action in the central nervous system., Endocrinology, 143巻, 9号, pp.3498-pp.3504, 20020901
  6. The mechanisms of immune-to-brain communication in inflammation as a drug target., Curr Drug Targets Inflamm Allergy., 1巻, 3号, pp.257-pp.262, 20020901
  7. Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms., Brain Res., 949巻, 1-2号, pp.139-pp.146, 20020901
  8. The presence and functions of muscarinic receptors in human T cells: the involvement in IL-2 and IL-2 receptor system., Life Sci., 72巻, 18-19号, pp.2121-pp.2126, 20030301
  9. Inhibition of leptin-induced IL-1beta expression by glucocorticoids in the brain., Brain Res., 969巻, 1-2号, pp.95-pp.101, 20030401
  10. A beta-induced TNF-alpha expression and acetylcholine action in mouse glial cells., Life Sci., 72巻, 18-19号, pp.2117-pp.2120, 20030301
  11. 中枢神経系における免疫機能とアルツハイマー病, 和光純薬時報, 71巻, 4号, pp.10-pp.11, 20031001
  12. Cholecystokinin inhibits food intake independent of interleukin-1 beta expression in the brain., Biol. Pharm. Bull., 26巻, 8号, pp.1181-pp.1183, 20030801
  13. Induction of murine HRD1 in experimental cerebral ischemia., Mol. Brain Res., 130巻, 1-2号, pp.30-pp.38, 20041101
  14. Bacterial endotoxin induces STAT3 activation in the mouse brain., Brain Res., 1023巻, 1号, pp.48-pp.53, 20041001
  15. Functional role of acetylcholine in the immune system., Front Biosci., 9巻, 1号, pp.2414-pp.2419, 20040901
  16. Effect of subdiaphragmatic vagotomy on bacterial DNA-induced IL-1beta expression in the mouse hypothalamus., Brain Res., 1028巻, 2号, pp.233-pp.237, 20041201
  17. Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction., J. Pharmacol. Exp. Ther., 311巻, 1号, pp.388-pp.393, 20041001
  18. Sodium 4-phenylbutyrate protects against cerebral ischemic injury., Mol Pharmacol, 66巻, 4号, pp.899-pp.908, 20041001
  19. Biochemical changes in the brain of senescence-accelerated mouse P8 and P10., International Congress Series, 1260巻, pp.91-pp.97, 2004
  20. Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells., Mol. Brain Res., 124巻, 2号, pp.159-pp.164, 20040501
  21. LPS induces stefin A3 expression in mouse primary cultured glial cells, MOLECULAR BRAIN RESEARCH, 140巻, 1-2号, pp.138-pp.141, OCT 31 2005
  22. Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 28巻, 8号, pp.1514-pp.1516, AUG 2005
  23. STAT3 activation and c-FOS expression in the brain following peripheral administration of bacterial DNA., J. Neuroimmunol., 158巻, 1-2号, pp.40-pp.49, 20050101
  24. Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion, AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 120巻, 1-2号, pp.104-pp.107, JUN 15 2005
  25. 脳循環とサイトカインー脳血管機能とサイトカイン, クリニカル・ニューロサイエンス, 23巻, 8号, pp.878-pp.879, 20050401
  26. 脳内免疫機構に関与するレプチンの役割とレプチン受容体機構, 日本薬理学会誌, 127巻, 1号, pp.25-pp.31, 20060101
  27. 2-aminopurine inhibits leptin receptor signal transduction, EUROPEAN JOURNAL OF PHARMACOLOGY, 553巻, 1-3号, pp.61-pp.66, DEC 28 2006
  28. Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress, JOURNAL OF NEUROCHEMISTRY, 97巻, 5号, pp.1259-pp.1268, JUN 2006
  29. PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 340巻, 1号, pp.286-pp.290, FEB 3 2006
  30. Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17巻, 2号, pp.184-pp.186, 20070201
  31. Akt up- and down-regulation in response to endoplasmic reticulum stress, BRAIN RESEARCH, 1152巻, pp.27-pp.31, JUN 4 2007
  32. Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression., European Journal of Pharmacology, 554巻, 1号, pp.8-pp.11, 20070105
  33. Vanadate inhibits endoplasmic reticulum stress responses, EUROPEAN JOURNAL OF PHARMACOLOGY, 594巻, 1-3号, pp.44-pp.48, OCT 10 2008
  34. Endoplasmic Reticulum Stress Induces Leptin Resistance, MOLECULAR PHARMACOLOGY, 74巻, 6号, pp.1610-pp.1619, DEC 2008
  35. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells, NEUROCHEMISTRY INTERNATIONAL, 54巻, 1号, pp.1-pp.6, JAN 2009
  36. Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance., Journal of Medical Investigation, 56巻, pp.296-pp.298, 2009
  37. 肥満とレプチン, Hiroshima Medical Care Council, 13巻, pp.27-pp.30, 2009
  38. Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities, CLINICAL SCIENCE, 118巻, 1-2号, pp.19-pp.29, JAN 2010
  39. A unique modulator of endoplasmic reticulum stress-signalling pathways: the novel pharmacological properties of amiloride in glial cells, BRITISH JOURNAL OF PHARMACOLOGY, 159巻, 2号, pp.428-pp.437, JAN 2010
  40. Homocysteine induces X-box-binding protein 1 splicing in the mice brain, NEUROCHEMISTRY INTERNATIONAL, 56巻, 2号, pp.216-pp.220, JAN 2010
  41. Potential Down-Regulation of Salivary Gland AQP5 by LPS via Cross-Coupling of NF-kappa B and p-c-Jun/c-Fos, AMERICAN JOURNAL OF PATHOLOGY, 177巻, 2号, pp.724-pp.734, AUG 2010
  42. Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice, PLOS ONE, 5巻, 9号, SEP 2 2010
  43. TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress, JOURNAL OF PHARMACOLOGICAL SCIENCES, 114巻, 2号, pp.230-pp.233, OCT 2010
  44. Novel Therapeutic Approach Based on Recent Understanding of the Development of Metabolic Syndrome, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 131巻, 11号, pp.1557-pp.1562, NOV 2011
  45. Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded proteinresponses in cultured glial cells., PLoS One, 7巻, (6)号, pp.e40144, 20120601
  46. Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance., Front Endocrinol (Lausanne), 20120101
  47. Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35巻, 1号, pp.84-pp.90, JAN 2012
  48. Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease: Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer's Disease, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118巻, 3号, pp.319-pp.324, MAR 2012
  49. Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice, GENE, 497巻, 2号, pp.340-pp.343, APR 15 2012
  50. Inhibition of Casein Kinase 2 Modulates XBP1-GRP78 Arm of Unfolded Protein Responses in Cultured Glial Cells, PLOS ONE, 7巻, 6号, JUN 29 2012
  51. ER stress-mediated regulation of immune function under glucose-deprived condition in glial cells: Up- and down-regulation of PGE(2) + IFN gamma-induced IL-6 and iNOS expressions, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441巻, 2号, pp.525-pp.528, NOV 15 2013
  52. Tributyltin-induced endoplasmic reticulum stress and its Ca2+-mediated mechanism, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272巻, 1号, pp.137-pp.146, OCT 1 2013
  53. ER stress upregulated PGE(2)/IFN gamma-induced IL-6 expression and down-regulated iNOS expression in glial cells, SCIENTIFIC REPORTS, 3巻, DEC 2 2013
  54. ★, Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress, EMBO MOLECULAR MEDICINE, 6巻, 3号, pp.335-pp.346, MAR 2014
  55. TERT attenuated ER stress-induced cell death, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 447巻, 2号, pp.378-pp.382, MAY 2 2014
  56. Inhibition of inducible nitric oxide synthase and interleukin-1 beta expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide, BRAIN RESEARCH, 1558巻, pp.11-pp.17, APR 16 2014
  57. Caffeine attenuated ER stress-induced leptin resistance in neurons, NEUROSCIENCE LETTERS, 569巻, pp.23-pp.26, MAY 21 2014
  58. Therapeutic potential of flurbiprofen against obesity in mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 449巻, 1号, pp.132-pp.134, JUN 20 2014
  59. Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells, SCIENTIFIC REPORTS, 4巻, NOV 18 2014
  60. Stress-Induced Neuroprotective Effects of Epiregulin and Amphiregulin, PLOS ONE, 10巻, 2号, FEB 12 2015
  61. Possible involvement of 15-deoxy-Delta(12,14)-prostaglandin J(2) in the development of leptin resistance, JOURNAL OF NEUROCHEMISTRY, 133巻, 3号, pp.343-pp.351, MAY 2015
  62. Stress-induced neuroprotective effects of epiregulin and amphiregulin., PLOS One, 10巻, pp.e0118280, 2015 Feb
  63. Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460巻, pp.628-pp.632, 2015 May
  64. Implementation and Evaluation of Genetic Testing Seminars on Lifestyle-related Disease Prevention for Pharmacy Students, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136巻, 2号, pp.337-pp.350, FEB 2016
  65. The Mechanisms and Pharmacological Strategy for Treatment of ER Stress-induced Metabolic Syndrome, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136巻, 6号, pp.827-pp.830, JUN 2016
  66. Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress to Ameliorate Leptin Resistance in Obesity, FRONTIERS IN ENDOCRINOLOGY, 7巻, JUN 8 2016
  67. Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation, BRITISH JOURNAL OF PHARMACOLOGY, 173巻, 15号, pp.2434-pp.2445, AUG 2016
  68. Immobilization stress-induced anorexia is mediated independent of MyD88, NEUROREPORT, 27巻, 13号, pp.974-pp.977, SEP 7 2016
  69. Possible involvement of endoplasmic reticulum stress in the pathogenesis of Alzheimer's disease., Endoplasmic Reticulum Stress in Diseases, 2巻, pp.107-pp.118
  70. Endoplasmic reticulum stress in the pathogenesis of diabetes., Diabesity, 1巻, pp.31-pp.33
  71. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, NEUROSCIENCE LETTERS, 629巻, pp.241-pp.244, AUG 26 2016
  72. Unique pharmacological property of ISRIB in inhibition of A beta-induced neuronal cell death, JOURNAL OF PHARMACOLOGICAL SCIENCES, 131巻, 4号, pp.292-pp.295, AUG 2016
  73. Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478巻, 2号, pp.716-pp.720, SEP 16 2016
  74. Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78, SCIENTIFIC REPORTS, 6巻, SEP 28 2016
  75. Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance, FRONTIERS IN PHARMACOLOGY, 7巻, SEP 30 2016
  76. Possible integrative Actions of Leptin and insulin Signaling in the Hypothalamus Targeting energy Homeostasis, FRONTIERS IN ENDOCRINOLOGY, 7巻, OCT 20 2016
  77. Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling, MOLECULAR METABOLISM, 6巻, 1号, pp.159-pp.172, JAN 2017
  78. Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in Neuronal Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40巻, 8号, pp.1161-pp.1164, AUG 2017
  79. 薬学部学生への生活習慣病予防に関する遺伝子検査の実施とそれを題材としたセミナーの評価., 薬学雑誌, 136巻, 2号, pp.337-pp.350, 20160201
  80. 誌上シンポジウム総説: 小胞体ストレスによる生活習慣病発症機構解明と創薬., 薬学雑誌, 136巻, 6号, pp.827-pp.830, 20160601
  81. Neuroprotection by endoplasmic reticulum stress-induced HRD1 and chaperones: possible therapeutic targets for Alzheimer’s and Parkinson’s diseases., Medical sciences, 4巻, pp.14

受賞

  1. 2011年10月08日, 日本脳科学会奨励賞, 日本脳科学会理事長 森 則夫, 肥満脳におけるレプチン受容体応答系抑制機構の解明と創薬:小胞体ストレスの関与
  2. 2011年03月, 平成23年度 日本薬学会奨励賞, 社団法人日本薬学会会頭, 生活習慣病の新機構解明と次世代型治療薬の開発研究
  3. 2015年02月02日, 平成26年度広島大学病院論文賞 ハイインパクト賞, 広島大学
  4. 2017年03月23日, 平成28年度広島大学薬学教育研究奨励賞, 広島大学, 広島大学薬学教育研究奨励賞