細井 徹Toru Hosoi

Last Updated :2019/11/01

所属・職名
大学院医系科学研究科(薬)(薬学)治療薬効学准教授
メールアドレス
toruhhiroshima-u.ac.jp

基本情報

学位

  • 博士(薬学)(北海道大学)
  • 修士(薬学)(北海道大学)

研究分野

  • 医歯薬学 / 薬学 / 薬理系薬学

研究キーワード

  • 神経変性疾患
  • 肥満
  • 小胞体ストレス

所属学会

教育活動

授業担当

  1. 2019年, 学部専門, 1ターム, 臨床薬物治療学A
  2. 2019年, 学部専門, 3ターム, 臨床薬理学A
  3. 2019年, 博士課程・博士課程後期, 3ターム, 薬物治療学特論
  4. 2019年, 博士課程・博士課程後期, 3ターム, 薬物治療学特論
  5. 2019年, 修士課程・博士課程前期, セメスター(前期), 分子治療薬効学特論演習
  6. 2019年, 修士課程・博士課程前期, セメスター(後期), 分子治療薬効学特論演習
  7. 2019年, 博士課程・博士課程後期, 3ターム, 薬物治療学
  8. 2019年, 修士課程・博士課程前期, セメスター(前期), 分子治療薬効学特論演習
  9. 2019年, 修士課程・博士課程前期, セメスター(後期), 分子治療薬効学特論演習

研究活動

学術論文(★は代表的な論文)

  1. Expression of leptin receptors and induction of IL-1beta transcript in glial cells., Biochem. Biophys. Res. Commun., 273巻, 1号, pp. 312-315, 20000601
  2. Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis., Am. J. Physiol., 279巻, 1号, pp. R141-R147, 20000701
  3. Subdiaphragmatic vagotomy fails to inhibit intravenous leptin-induced IL-1beta expression in the hypothalamus., Am. J. Physiol., 282巻, 2号, pp. R627-R631, 20020201
  4. Leptin induces IL-1 receptor antagonist expression in the brain., Biochem. Biophys. Res. Commun., 294巻, 2号, pp. 215-219, 20020601
  5. ★, Brain stem is a direct target for leptin’s action in the central nervous system., Endocrinology, 143巻, 9号, pp. 3498-3504, 20020901
  6. The mechanisms of immune-to-brain communication in inflammation as a drug target., Curr Drug Targets Inflamm Allergy., 1巻, 3号, pp. 257-262, 20020901
  7. Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms., Brain Res., 949巻, 1-2号, pp. 139-146, 20020901
  8. The presence and functions of muscarinic receptors in human T cells: the involvement in IL-2 and IL-2 receptor system., Life Sci., 72巻, 18-19号, pp. 2121-2126, 20030301
  9. Inhibition of leptin-induced IL-1beta expression by glucocorticoids in the brain., Brain Res., 969巻, 1-2号, pp. 95-101, 20030401
  10. A beta-induced TNF-alpha expression and acetylcholine action in mouse glial cells., Life Sci., 72巻, 18-19号, pp. 2117-2120, 20030301
  11. 中枢神経系における免疫機能とアルツハイマー病, 和光純薬時報, 71巻, 4号, pp. 10-11, 20031001
  12. Cholecystokinin inhibits food intake independent of interleukin-1 beta expression in the brain., Biol. Pharm. Bull., 26巻, 8号, pp. 1181-1183, 20030801
  13. Induction of murine HRD1 in experimental cerebral ischemia., Mol. Brain Res., 130巻, 1-2号, pp. 30-38, 20041101
  14. Bacterial endotoxin induces STAT3 activation in the mouse brain., Brain Res., 1023巻, 1号, pp. 48-53, 20041001
  15. Functional role of acetylcholine in the immune system., Front Biosci., 9巻, 1号, pp. 2414-2419, 20040901
  16. Effect of subdiaphragmatic vagotomy on bacterial DNA-induced IL-1beta expression in the mouse hypothalamus., Brain Res., 1028巻, 2号, pp. 233-237, 20041201
  17. Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction., J. Pharmacol. Exp. Ther., 311巻, 1号, pp. 388-393, 20041001
  18. Sodium 4-phenylbutyrate protects against cerebral ischemic injury., Mol Pharmacol, 66巻, 4号, pp. 899-908, 20041001
  19. Biochemical changes in the brain of senescence-accelerated mouse P8 and P10., International Congress Series, 1260巻, pp. 91-97, 2004
  20. Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells., Mol. Brain Res., 124巻, 2号, pp. 159-164, 20040501
  21. LPS induces stefin A3 expression in mouse primary cultured glial cells, MOLECULAR BRAIN RESEARCH, 140巻, 1-2号, pp. 138-141, 20051031
  22. Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 28巻, 8号, pp. 1514-1516, 200508
  23. STAT3 activation and c-FOS expression in the brain following peripheral administration of bacterial DNA., J. Neuroimmunol., 158巻, 1-2号, pp. 40-49, 20050101
  24. Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion, AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 120巻, 1-2号, pp. 104-107, 20050615
  25. 脳循環とサイトカインー脳血管機能とサイトカイン, クリニカル・ニューロサイエンス, 23巻, 8号, pp. 878-879, 20050401
  26. 脳内免疫機構に関与するレプチンの役割とレプチン受容体機構, 日本薬理学会誌, 127巻, 1号, pp. 25-31, 20060101
  27. 2-aminopurine inhibits leptin receptor signal transduction, EUROPEAN JOURNAL OF PHARMACOLOGY, 553巻, 1-3号, pp. 61-66, 20061228
  28. Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress, JOURNAL OF NEUROCHEMISTRY, 97巻, 5号, pp. 1259-1268, 200606
  29. PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 340巻, 1号, pp. 286-290, 20060203
  30. Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17巻, 2号, pp. 184-186, 20070201
  31. Akt up- and down-regulation in response to endoplasmic reticulum stress, BRAIN RESEARCH, 1152巻, pp. 27-31, 20070604
  32. Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression., European Journal of Pharmacology, 554巻, 1号, pp. 8-11, 20070105
  33. Vanadate inhibits endoplasmic reticulum stress responses, EUROPEAN JOURNAL OF PHARMACOLOGY, 594巻, 1-3号, pp. 44-48, 20081010
  34. Endoplasmic Reticulum Stress Induces Leptin Resistance, MOLECULAR PHARMACOLOGY, 74巻, 6号, pp. 1610-1619, 200812
  35. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells, NEUROCHEMISTRY INTERNATIONAL, 54巻, 1号, pp. 1-6, 200901
  36. Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance., Journal of Medical Investigation, 56巻, pp. 296-298, 2009
  37. 肥満とレプチン, Hiroshima Medical Care Council, 13巻, pp. 27-30, 2009
  38. Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities, CLINICAL SCIENCE, 118巻, 1-2号, pp. 19-29, 201001
  39. A unique modulator of endoplasmic reticulum stress-signalling pathways: the novel pharmacological properties of amiloride in glial cells, BRITISH JOURNAL OF PHARMACOLOGY, 159巻, 2号, pp. 428-437, 201001
  40. Homocysteine induces X-box-binding protein 1 splicing in the mice brain, NEUROCHEMISTRY INTERNATIONAL, 56巻, 2号, pp. 216-220, 201001
  41. Potential Down-Regulation of Salivary Gland AQP5 by LPS via Cross-Coupling of NF-kappa B and p-c-Jun/c-Fos, AMERICAN JOURNAL OF PATHOLOGY, 177巻, 2号, pp. 724-734, 201008
  42. Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice, PLOS ONE, 5巻, 9号, 20100902
  43. TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress, JOURNAL OF PHARMACOLOGICAL SCIENCES, 114巻, 2号, pp. 230-233, 201010
  44. Novel Therapeutic Approach Based on Recent Understanding of the Development of Metabolic Syndrome, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 131巻, 11号, pp. 1557-1562, 201111
  45. Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded proteinresponses in cultured glial cells., PLoS One, 7巻, (6)号, pp. e40144, 20120601
  46. Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance., Front Endocrinol (Lausanne), 20120101
  47. Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35巻, 1号, pp. 84-90, 201201
  48. Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease: Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer's Disease, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118巻, 3号, pp. 319-324, 201203
  49. Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice, GENE, 497巻, 2号, pp. 340-343, 20120415
  50. Inhibition of Casein Kinase 2 Modulates XBP1-GRP78 Arm of Unfolded Protein Responses in Cultured Glial Cells, PLOS ONE, 7巻, 6号, 20120629
  51. ER stress-mediated regulation of immune function under glucose-deprived condition in glial cells: Up- and down-regulation of PGE(2) + IFN gamma-induced IL-6 and iNOS expressions, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441巻, 2号, pp. 525-528, 20131115
  52. Tributyltin-induced endoplasmic reticulum stress and its Ca2+-mediated mechanism, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272巻, 1号, pp. 137-146, 20131001
  53. ER stress upregulated PGE(2)/IFN gamma-induced IL-6 expression and down-regulated iNOS expression in glial cells, SCIENTIFIC REPORTS, 3巻, 20131202
  54. ★, Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress, EMBO MOLECULAR MEDICINE, 6巻, 3号, pp. 335-346, 201403
  55. TERT attenuated ER stress-induced cell death, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 447巻, 2号, pp. 378-382, 20140502
  56. Inhibition of inducible nitric oxide synthase and interleukin-1 beta expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide, BRAIN RESEARCH, 1558巻, pp. 11-17, 20140416
  57. Caffeine attenuated ER stress-induced leptin resistance in neurons, NEUROSCIENCE LETTERS, 569巻, pp. 23-26, 20140521
  58. Therapeutic potential of flurbiprofen against obesity in mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 449巻, 1号, pp. 132-134, 20140620
  59. Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells, SCIENTIFIC REPORTS, 4巻, 20141118
  60. Stress-Induced Neuroprotective Effects of Epiregulin and Amphiregulin, PLOS ONE, 10巻, 2号, 20150212
  61. Possible involvement of 15-deoxy-Delta(12,14)-prostaglandin J(2) in the development of leptin resistance, JOURNAL OF NEUROCHEMISTRY, 133巻, 3号, pp. 343-351, 201505
  62. Stress-induced neuroprotective effects of epiregulin and amphiregulin., PLOS One, 10巻, pp. e0118280, 201502
  63. Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460巻, pp. 628-632, 201505
  64. Implementation and Evaluation of Genetic Testing Seminars on Lifestyle-related Disease Prevention for Pharmacy Students, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136巻, 2号, pp. 337-350, 201602
  65. The Mechanisms and Pharmacological Strategy for Treatment of ER Stress-induced Metabolic Syndrome, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136巻, 6号, pp. 827-830, 201606
  66. Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress to Ameliorate Leptin Resistance in Obesity, FRONTIERS IN ENDOCRINOLOGY, 7巻, 20160608
  67. Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation, BRITISH JOURNAL OF PHARMACOLOGY, 173巻, 15号, pp. 2434-2445, 201608
  68. Immobilization stress-induced anorexia is mediated independent of MyD88, NEUROREPORT, 27巻, 13号, pp. 974-977, 20160907
  69. 小胞体ストレスを標的とした生活習慣病の新規治療薬開発戦略, 広島医療情報研究会, 19巻, pp. 8-10
  70. Possible involvement of endoplasmic reticulum stress in the pathogenesis of Alzheimer's disease., Endoplasmic Reticulum Stress in Diseases, 2巻, pp. 107-118, 2015
  71. Endoplasmic reticulum stress in the pathogenesis of diabetes., Diabesity, 1巻, pp. 31-33, 2015
  72. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, NEUROSCIENCE LETTERS, 629巻, pp. 241-244, 20160826
  73. Unique pharmacological property of ISRIB in inhibition of A beta-induced neuronal cell death, JOURNAL OF PHARMACOLOGICAL SCIENCES, 131巻, 4号, pp. 292-295, 201608
  74. Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478巻, 2号, pp. 716-720, 20160916
  75. Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78, SCIENTIFIC REPORTS, 6巻, 20160928
  76. Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance, FRONTIERS IN PHARMACOLOGY, 7巻, 20160930
  77. Possible integrative Actions of Leptin and insulin Signaling in the Hypothalamus Targeting energy Homeostasis, FRONTIERS IN ENDOCRINOLOGY, 7巻, 20161020
  78. ★, Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling, MOLECULAR METABOLISM, 6巻, 1号, pp. 159-172, 201701
  79. Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in Neuronal Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40巻, 8号, pp. 1161-1164, 201708
  80. 薬学部学生への生活習慣病予防に関する遺伝子検査の実施とそれを題材としたセミナーの評価., 薬学雑誌, 136巻, 2号, pp. 337-350, 20160201
  81. 誌上シンポジウム総説: 小胞体ストレスによる生活習慣病発症機構解明と創薬., 薬学雑誌, 136巻, 6号, pp. 827-830, 20160601
  82. 小胞体ストレス・小胞体ストレス応答, アレルギー, 65巻, pp. 947-948, 2016
  83. Neuroprotection by endoplasmic reticulum stress-induced HRD1 and chaperones: possible therapeutic targets for Alzheimer’s and Parkinson’s diseases., Medical sciences, 4巻, pp. 14, 2016
  84. Neuroprotective effects of 4-phenylbutyric acid and its derivatives: Possible therapeutics for neurodegenerative diseases., Journal of Health Science, 5巻, pp. 9-17, 2017
  85. Implementation and Evaluation of Genetic Testing Seminars about Lifestyle-related Disease Prevention in Pharmacy Insurance -The Need for Cooperation between the Pharmacy and the University in Genetic Testing-, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 137巻, 12号, pp. 1517-1531, 201712
  86. Mechanisms of the action of adenine on anti-allergic effects in mast cells, IMMUNITY INFLAMMATION AND DISEASE, 6巻, 1号, pp. 97-105, 201803
  87. TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses, BIOTECHNOLOGY LETTERS, 40巻, 6号, pp. 915-922, 201806
  88. Leptin resistance in metabolic disorders: possible mechanisms and treatments., Frontiers in Endocrinology, 8巻, 300号, pp. 1-2, 20171102
  89. Link between endoplasmic reticulum stress and autophagy in neurodegenerative diseases., Endoplasmic Reticulum Stress in Diseases, 4巻, pp. 37-45, 20171116
  90. Incorporation of the Endoplasmic Reticulum Stress-Induced Spliced Form of XBP1 mRNA in the Exosomes, FRONTIERS IN PHYSIOLOGY, 9巻, SEP 26 2018

招待講演、口頭・ポスター発表等

  1. GAPDHの遊離機構とamyloidβによる神経毒性からの保護作用, 田中景吾, 細井 徹, 野口 純, 小澤光一郎, 第129回日本薬理学会近畿部会, 2016年06月24日, 通常, 日本語, 広島市
  2. マウスにおけるアルデヒドデヒドロゲナーゼ2欠損による行動異常の発現, 森 光平, 細井 徹, 北川恭子, 小澤 光一郎, 第55回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, 2016年11月05日, 通常, 日本語, 岡山市
  3. GAPDHの細胞外遊離機構とアルツハイマー病発症への関わり, 田中景吾, 細井 徹, 野口 純, 小澤光一郎, 第55回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, 2016年11月05日, 通常, 日本語, 岡山市
  4. 小胞体ストレス応答機構を標的とする和漢薬由来抗アルツハイマー病薬の創製研究, 野村靖幸, 西 昭徳, 小澤孝一郎, 細井 徹, 金子雅幸, 東田千尋, 富山大学和漢医薬学総合研究所 平成28年度共同研究報告セミナー, 通常, 日本語
  5. 生薬 alkannin と shikonin のAβとタウタンパク凝集阻害と神経細胞死阻害活性:抗アルツハイマー病薬創製に向けて, 細井 徹, 俵明 里, 今田理裕, 東田千尋, 金子雅幸, 藤田有紀, 奥田充顕, 杉本八郎, 小澤光一郎, 西昭徳, 野村靖幸, 日本薬学会第137年会, 2017年03月24日, 通常, 日本語
  6. プロテインキナーゼCによる小胞体ストレス応答制御機構の解明, 森本純加, 細井 徹, 末澤隆浩, 櫨木 薫, 櫨木 修, 小澤光一郎, 日本薬学会第137年会, 2017年03月24日, 通常, 日本語
  7. 生活習慣病予防のための遺伝子検査セミナー―保険薬局での一般市民を対象とした検討―, 池田 佳代, 春日 真由, 細井 徹, 吉井 美智子, 杉山 政則, 若生 あき, 小澤 光一郎, 日本薬学会第137年会, 2017年03月24日, 通常, 日本語

受賞

  1. 2011年10月08日, 日本脳科学会奨励賞, 日本脳科学会理事長 森 則夫, 肥満脳におけるレプチン受容体応答系抑制機構の解明と創薬:小胞体ストレスの関与
  2. 2011年03月, 平成23年度 日本薬学会奨励賞, 社団法人日本薬学会会頭, 生活習慣病の新機構解明と次世代型治療薬の開発研究
  3. 2015年02月02日, 平成26年度広島大学病院論文賞 ハイインパクト賞, 広島大学
  4. 2017年03月23日, 平成28年度広島大学薬学教育研究奨励賞, 広島大学, 広島大学薬学教育研究奨励賞