MAKOKHA GRACE NASWAGRACE NASWA MAKOKHA

Last Updated :2018/11/01

所属・職名
大学院医歯薬保健学研究科(医) 医学講座 特任助教
メールアドレス
gnaswahiroshima-u.ac.jp

基本情報

主な職歴

  • 2014年04月01日, 2015年03月31日, 広島大学, 大学院医歯薬保健学研究院, 研究員
  • 2015年04月01日, 広島大学, 大学院医歯薬保健学研究院, 助教

学歴

  • 新潟大学, 大学院医歯薬学総合研究科, 地域疾病制御医学専攻博士課程, 日本, 2009年10月, 2013年09月
  • マセノ大学, 公衆衛生学, ケニア, 2002年01月, 2006年12月
  • Maseno University, Biomedical Sciences, Biomedical Sciences and Technology, Kenya, 2002年01月, 2006年12月

学位

  • 博士(医学) (新潟大学)

所属学会

  • Japanese Cancer Association, 2012年03月
  • Japan Society of Hepatology, 2017年10月

研究活動

学術論文(★は代表的な論文)

  1. Early events in hepatitis B virus infection: From the cell surface to the nucleus, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 31巻, 2号, pp.302-pp.309, FEB 2016
  2. Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection, JOURNAL OF GASTROENTEROLOGY, 51巻, 11号, pp.1073-pp.1080, NOV 2016
  3. Protease Inhibitor Resistance Remains Even After Mutant Strains Become Undetectable by Deep Sequencing, JOURNAL OF INFECTIOUS DISEASES, 214巻, 11号, pp.1687-pp.1694, DEC 1 2016
  4. Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus, PLOS ONE, 12巻, 3号, MAR 2 2017
  5. Real-world efficacy and safety of daclatasvir and asunaprevir therapy for hepatitis C virus-infected cirrhosis patients, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 32巻, 3号, pp.645-pp.650, MAR 2017
  6. ITPA polymorphism effects on decrease of hemoglobin during sofosbuvir and ribavirin combination treatment for chronic hepatitis C, JOURNAL OF GASTROENTEROLOGY, 52巻, 6号, pp.746-pp.753, JUN 2017
  7. Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61巻, 6号, JUN 2017
  8. Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology, JOURNAL OF GENERAL VIROLOGY, 98巻, 5号, pp.1040-pp.1047, MAY 2017
  9. Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy, JOURNAL OF GASTROENTEROLOGY, 53巻, 1号, pp.107-pp.118, JAN 2018
  10. Persistent Loss of Hepatitis B Virus Markers in Serum without Cellular Immunity by Combination of Peginterferon and Entecavir Therapy in Humanized Mice, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61巻, 9号, SEP 2017
  11. Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 500巻, 2号, pp.152-pp.157, JUN 2 2018
  12. Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure, JOURNAL OF GENERAL VIROLOGY, 99巻, 8号, pp.1058-pp.1065, AUG 2018
  13. Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes, Virology, 525巻, pp.48-pp.61, 2018 SEPT
  14. CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients, Journal of Viral Hepatitis, JULY 2018
  15. The association between serum cytokine and chemokine levels and antiviral response by entecavir treatment in chronic hepatitis B patients, Antiviral Therapy, 23巻, 3号, pp.239-pp.248, SEPT 2017
  16. HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10, Blood, 122巻, 5号, pp.715-pp.725, AUG 2013
  17. Both G3BP1 and G3BP2 contribute to stress granule formation, Genes to Cells, 18巻, 2号, pp.135-pp.146, FEB 2013
  18. Human T-cell leukemia virus type 1 Tax protein interacts with and mislocalizes the PDZ domain protein MAGI-1, Cancer Science, 104巻, 3号, pp.313-pp.320, MARCH 2013

招待講演、口頭・ポスター発表等

  1. TARDBP regulates HBV transcription and replication through interaction with the core promoter, The Liver Meeting 2017, 2017年10月22日, 通常, 英語