小林 正夫Masao Kobayashi

Last Updated :2017/09/01

大学院医歯薬保健学研究科(医) 医学講座 教授



  • 医学博士 (広島大学)


  • 医歯薬学 / 内科系臨床医学 / 小児科学


  • 学校保健
  • 造血幹細胞
  • 好中球減少症
  • 育児
  • 悪性腫瘍



  1. 2017年, 学部専門, 集中, 全身性疾患制御学
  2. 2017年, 学部専門, 集中, 臨床実習・臨床実践学
  3. 2017年, 学部専門, 集中, 医学研究実習
  4. 2017年, 学部専門, 集中, アドバンスト医学実習
  5. 2017年, 学部専門, セメスター(前期), 小児科学
  6. 2017年, 学部専門, セメスター(前期), 小児科学
  7. 2017年, 修士課程・博士課程前期, セメスター(前期), 情報医工学特論
  8. 2017年, 博士課程・博士課程後期, セメスター(前期), 小児科学特別実験
  9. 2017年, 博士課程・博士課程後期, セメスター(後期), 小児科学特別実験
  10. 2017年, 博士課程・博士課程後期, セメスター(前期), 小児科学特別演習
  11. 2017年, 博士課程・博士課程後期, セメスター(後期), 小児科学特別演習
  12. 2017年, 博士課程・博士課程後期, セメスター(前期), 小児保健学



  1. Identification of the integrin beta 3 L718P mutation in a pedigree with autosomal dominant thrombocytopenia with anisocytosis, BRITISH JOURNAL OF HAEMATOLOGY, 160巻, 4号, pp.521-pp.529, FEB 2013
  2. Central nervous system complications and neuroradiological findings in children with chronic active EpsteinBarr virus infection, PEDIATRICS INTERNATIONAL, 55巻, 1号, pp.72-pp.78, FEB 2013
  3. Effects of idursulfase enzyme replacement therapy for Mucopolysaccharidosis type II when started in early infancy: Comparison in two siblings, MOLECULAR GENETICS AND METABOLISM, 108巻, 3号, pp.172-pp.177, MAR 2013
  4. Acute severe encephalopathy related to human herpesvirus-6 infection in a patient with carnitine palmitoyltransferase 2 deficiency carrying thermolabile variants, BRAIN & DEVELOPMENT, 35巻, 5号, pp.449-pp.453, MAY 2013
  5. Paroxysmal Periodic Dystonic Postures in an Infant with 18q23 Deletion Syndrome, NEUROPEDIATRICS, 44巻, 3号, pp.163-pp.166, JUN 2013
  6. Heterozygosity for the Y701C STAT1 mutation in a multiplex kindred with multifocal osteomyelitis, HAEMATOLOGICA, 98巻, 10号, pp.1641-pp.1649, OCT 2013
  7. Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia-derived pluipotent stem cells with heterozygous ELANE mutation, Proc Natl Acad Sci USA, 110巻, pp.3023-8, 20130601
  8. 小児急性白血病長期生存者28例の内分泌学的検討 -白血病治療内容と内分泌合併症の相関-, ホルモンと臨床, 57巻, pp.1037-pp.1040, 20090501
  9. 血液疾患における病態解析研究の進歩:先天性好中球減少症発症機構解明の進展, 血液・腫瘍科, 60巻, 2号, pp.118-pp.124, 20100501
  10. 小児がん患者の実際や治療時におこりうる額顔面領域の問題点, 小児歯科臨床, 15巻, pp.24-pp.28, 20100601
  11. 好中球減少症, 小児科, 51巻, pp.985-pp.994, 20100701
  12. 低用量リツキシマブ投与が奏功し1年間に渡る完全寛解を維持している慢性自己免疫性好中球減少症, 臨床血液, 52巻, 2号, pp.63-pp.67, 20110601
  13. Glanzmann thrombasthenia (GT) の遺伝子組み換え活性型第Ⅶ因子製剤による止血効果, 日本小児血液・がん学会雑誌, 49巻, pp.61-pp.66, 20120601
  14. 在宅人工呼吸器装着者の災害時対策, 小児内科, 45巻, 1号, pp.116-pp.120, 20130101
  15. Abnormal responses of myeloid progenitor cells to recombinant human colony-stimulating factors in congenital neutropenia., Blood, 75巻, pp.2143-pp.2149, 19900401
  16. Detection Of Mucor velutinosus in a Blood Culture After Autologous Periperal Blood Stem Cell Transplantation: A Pediatric Case Report, Medical Mycology Journal, 55巻, 2号, pp.E43-8, 20140601
  17. ZK7, a novel zinc finger gene is induced by vascular endothelial growth factor and inhibits apoptotic death in hematopoietic cells, CANCER RESEARCH, 60巻, 2号, pp.425-pp.430, JAN 15 2000
  18. Insulin and insulin-like growth factor I support the proliferation of erythroid progenitor cells in bone marrow through the sharing of receptors, BRITISH JOURNAL OF HAEMATOLOGY, 109巻, 3号, pp.555-pp.562, JUN 2000
  19. Abnormalities of primitive myeloid progenitor cells expressing granulocyte colony-stimulating factor receptor in patients with severe congenital neutropenia, BLOOD, 96巻, 13号, pp.4366-pp.4369, DEC 15 2000
  20. A possible role for maternal HLA antibody in a case of alloimmune neonatal neutropenia, TRANSFUSION, 41巻, 5号, pp.615-pp.620, MAY 2001
  21. Significance of the detection of antineutrophil antibodies in children with chronic neutropenia, BLOOD, 99巻, 9号, pp.3468-pp.3471, MAY 1 2002
  22. Human neutrophil antigen-2a expression on neutrophils from healthy adults in western Japan, TRANSFUSION, 42巻, 5号, pp.651-pp.657, MAY 2002
  23. Dysregulation of transcriptions in primary granule constituents, during myeloid proliferation and differentiation in patients with severe congenital neutropenia, JOURNAL OF LEUKOCYTE BIOLOGY, 73巻, 2号, pp.225-pp.234, FEB 2003
  24. Efficacy of prophylactic use of trimethoprim-sulfamethoxazole in autoimmune neutropenia in infancy, JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 25巻, 7号, pp.553-pp.557, JUL 2003
  25. Establishment of a practical enzymatic assay method for determination of isovaleryl-CoA dehydrogenase activity using high-performance liquid chromatography, CLINICA CHIMICA ACTA, 353巻, 1-2号, pp.193-pp.199, MAR 2005
  26. Significance of human neutrophil antigen-2a (NB1) expression and neutrophil number in pregnancy, TRANSFUSION, 44巻, 4号, pp.581-pp.585, APR 2004
  27. A case of adolescent primary adrenal natural killer cell lymphoma, INTERNATIONAL JOURNAL OF HEMATOLOGY, 81巻, 4号, pp.330-pp.334, MAY 2005
  28. Enzymatic diagnosis of medium-chain acyl-CoA dehydrogenase deficiency by detecting 2-octenoyl-CoA production using high-performance liquid chromatography: A practical confirmatory test for tandem mass spectrometry newborn screening in Japan, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 823巻, 2号, pp.122-pp.130, SEP 5 2005
  29. A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 90巻, 8号, pp.1032-pp.1041, AUG 2005
  30. Effect of green tea beverages on efficacy of povidone-iodine, JOURNAL OF HEALTH SCIENCE, 52巻, 3号, pp.324-pp.328, JUN 2006
  31. Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells, GENES CHROMOSOMES & CANCER, 46巻, 1号, pp.67-pp.74, JAN 2007
  32. Autoimmune neutropenia of infancy with multiple brain abscesses during the course of human herpesvirus-6 infection, INTERNATIONAL JOURNAL OF HEMATOLOGY, 84巻, 2号, pp.151-pp.153, AUG 2006
  33. Moyamoya syndrome after cranial irradiation for bone marrow transplantation in a patient with acute leukemia, NEUROPEDIATRICS, 37巻, 6号, pp.364-pp.366, DEC 2006
  34. Frontal cerebral blood flow change associated with infant-directed speech, ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 92巻, 2号, pp.F113-pp.F116, MAR 2007
  35. Successful treatment with liposteroid followed by reduced intensity stem cell transplantation in an infant with perforin deficiency presenting with hemophagocytic lymphohistiocytosis, JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 29巻, 3号, pp.178-pp.182, MAR 2007
  36. The function of the frontal lobe in neonates for response to a prosodic voice, EARLY HUMAN DEVELOPMENT, 83巻, 4号, pp.225-pp.230, APR 2007
  37. A novel mutation (Gln433Glu) in exon 12 combined with the G insertion in exon 13 causes severe factor XI deficiency in Japanese patients, BLOOD COAGULATION & FIBRINOLYSIS, 18巻, 5号, pp.519-pp.523, JUL 2007
  38. The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-gamma receptor 1 and has a dominant-negative effect on interferon-gamma signal transduction, JOURNAL OF MEDICAL GENETICS, 44巻, 8号, pp.485-pp.491, AUG 2007
  39. Floating culture promotes the maintenance of hematopoietic stem cells, FEBS LETTERS, 581巻, 24号, pp.4645-pp.4650, OCT 2 2007
  40. The mobility of Bach2 nuclear foci is regulated by SUMO-1 modification, EXPERIMENTAL CELL RESEARCH, 314巻, 4号, pp.903-pp.913, FEB 15 2008
  41. Detection of autoantibodies against NMDA-type glutamate receptor in a patient with recurrent optic neuritis and transient cerebral lesions, NEUROPEDIATRICS, 38巻, 5号, pp.257-pp.260, OCT 2007
  42. Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105巻, 30号, pp.10396-pp.10401, JUL 29 2008
  43. Development of a New Enzymatic Diagnosis Method for Very-long-chain Acyl-CoA Dehydrogenase Deficiency by Detecting 2-Hexadecenoyl-CoA Production and its Application in Tandem Mass Spectrometry-based Selective Screening and Newborn Screening in Japan, PEDIATRIC RESEARCH, 64巻, 6号, pp.667-pp.672, DEC 2008
  44. Neurodevelopmental abnormalities associated with severe congenital neutropenia due to the R86X mutation in the HAX1 gene, JOURNAL OF MEDICAL GENETICS, 45巻, 12号, pp.802-pp.807, DEC 2008
  46. Different neuroradiological findings during two stroke-like episodes in a patient with a congenital disorder of glycosylation type Ia, BRAIN & DEVELOPMENT, 31巻, 3号, pp.240-pp.243, MAR 2009
  47. Dizygotic twins with neonatal alloimmune neutropenia associated with maternal anti-human neutrophil antigen-1b antibody, PEDIATRICS INTERNATIONAL, 51巻, 2号, pp.298-pp.299, APR 2009
  48. Epileptic Spasms After Stem Cell Transplantation for Chronic Epstein-Barr Virus Infection, PEDIATRIC NEUROLOGY, 40巻, 5号, pp.404-pp.407, MAY 2009
  49. Ela2 Mutations and Clinical Manifestations in Familial Congenital Neutropenia, JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 31巻, 5号, pp.319-pp.324, MAY 2009
  50. Deficiency of regulatory T cells in children with autoimmune neutropenia, BRITISH JOURNAL OF HAEMATOLOGY, 145巻, 5号, pp.642-pp.647, JUN 2009
  51. Current Situation of Drug Information in the Kindergarten and Nursery Teacher: A Pilot Study, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 129巻, 5号, pp.617-pp.622, MAY 2009
  52. Spinal Epidural Granulocytic Sarcoma in a Child Precedent to Clinical Manifestation of Acute Myeloid Lymphoma -Case Report-, NEUROLOGIA MEDICO-CHIRURGICA, 49巻, 5号, pp.221-pp.224, MAY 2009
  53. Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells, EXPERIMENTAL HEMATOLOGY, 37巻, 7号, pp.857-pp.866, JUL 2009
  54. Short-Term Culture of Umbilical Cord Blood-Derived CD34 Cells Enhances Engraftment Into NOD/SCID Mice Through Increased CXCR4 Expression, STEM CELLS AND DEVELOPMENT, 18巻, 8号, pp.1221-pp.1226, OCT 2009
  55. Successful bone marrow transplantation in chronic granulomatous disease, PEDIATRICS INTERNATIONAL, 51巻, 6号, pp.838-pp.841, DEC 2009
  56. Significance of immature platelet fraction and CD41-positive cells at birth in early onset neonatal thrombocytopenia, INTERNATIONAL JOURNAL OF HEMATOLOGY, 91巻, 2号, pp.245-pp.251, MAR 2010
  57. Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency, HUMAN GENETICS, 127巻, 6号, pp.619-pp.628, JUN 2010
  58. Recurrent acute cerebellar ataxia associated with anti-cardiolipin antibodies, BRAIN & DEVELOPMENT, 32巻, 7号, pp.588-pp.591, AUG 2010
  59. Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107巻, 50号, pp.21529-pp.21534, DEC 14 2010
  60. Identification of therapy-sensitive and therapy-resistant neuroblastoma subtypes in stages III, IVs and IV, CANCER LETTERS, 306巻, 1号, pp.27-pp.33, JUL 1 2011
  61. Clinical and Host Genetic Characteristics of Mendelian Susceptibility to Mycobacterial Diseases in Japan, JOURNAL OF CLINICAL IMMUNOLOGY, 31巻, 3号, pp.309-pp.314, JUN 2011
  62. Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis, JOURNAL OF EXPERIMENTAL MEDICINE, 208巻, 8号, pp.1635-pp.1648, AUG 1 2011
  63. Association of viral isolates from stool samples with intussusception in children, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 15巻, 9号, pp.E641-pp.E645, SEP 2011
  64. A Case of Neonatal Coxsackie B2 Meningo-Encephalitis in which Serial Magnetic Resonance Imaging Findings Reveal the Development of Lesions, NEUROPEDIATRICS, 42巻, 4号, pp.156-pp.158, AUG 2011
  65. Decreased Expression in Nuclear Factor-kappa B Essential Modulator Due to a Novel Splice-Site Mutation Causes X-linked Ectodermal Dysplasia with Immunodeficiency, JOURNAL OF CLINICAL IMMUNOLOGY, 31巻, 5号, pp.762-pp.772, OCT 2011
  66. Nationwide Survey of Patients with Primary Immunodeficiency Diseases in Japan, JOURNAL OF CLINICAL IMMUNOLOGY, 31巻, 6号, pp.968-pp.976, DEC 2011
  67. Evaluation of cerebellar mutism by arterial spin-labeling perfusion magnetic resonance imaging in a patient with atypical teratoid/rhabdoid tumor (AT/RT): a case report, CHILDS NERVOUS SYSTEM, 28巻, 8号, pp.1257-pp.1260, AUG 2012
  68. Endocrine complications in primary immunodeficiency diseases in Japan, CLINICAL ENDOCRINOLOGY, 77巻, 4号, pp.628-pp.634, OCT 2012
  69. Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110巻, 8号, pp.3023-pp.3028, FEB 19 2013
  70. Reduced brain activation during imitation and observation of others in children with pervasive developmental disorder: a pilot study, BEHAVIORAL AND BRAIN FUNCTIONS, 9巻, MAY 29 2013
  71. Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132巻, 2号, pp.400-pp.+, AUG 2013
  72. Management of advanced-stage neuroblastoma in a patient with 21-hydroxalase deficiency, PEDIATRICS INTERNATIONAL, 55巻, 4号, pp.E96-pp.E99, AUG 2013
  73. Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells, JOURNAL OF EXPERIMENTAL MEDICINE, 210巻, 12号, pp.2739-pp.2753, NOV 18 2013
  74. IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts, BLOOD, 122巻, 24号, pp.3940-pp.3950, DEC 5 2013
  75. Ictal Electroencephalography and Electromyography Features in Symptomatic Infantile Epileptic Encephalopathy with Late-Onset Spasms, NEUROPEDIATRICS, 45巻, 1号, pp.36-pp.41, FEB 2014
  76. Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis, JOURNAL OF LEUKOCYTE BIOLOGY, 95巻, 4号, pp.667-pp.676, APR 2014
  77. Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis, HAEMATOLOGICA, 99巻, 1号, pp.19-pp.27, JAN 2014
  78. A Pediatric Case of Peripheral Polyneuropathy With IgM anti-GM1 Antibody Associated With a Group A Beta-Hemolytic Streptococcus Infection, PEDIATRIC NEUROLOGY, 51巻, 3号, pp.441-pp.443, SEP 2014
  79. Gene Alterations Involving the CRLF2-JAK Pathway and Recurrent Gene Deletions in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan, GENES CHROMOSOMES & CANCER, 53巻, 11号, pp.902-pp.910, NOV 2014
  80. Compound heterozygosity in GPR56 with bilateral frontoparietal polymicrogyria, BRAIN & DEVELOPMENT, 36巻, 6号, pp.528-pp.531, JUN 2014
  81. Increased interleukin-6 and high-sensitivity C-reactive protein levels in pediatric epilepsy patients with frequent, refractory generalized motor seizures, SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 25巻, pp.136-pp.140, FEB 2015
  82. The International Immune Tolerance Induction Study and its follow-up study on Japanese hemophilia A patients with inhibitors, INTERNATIONAL JOURNAL OF HEMATOLOGY, 101巻, 4号, pp.362-pp.368, APR 2015
  83. The postirradiation incidence of cavernous angioma is higher in patients with childhood pineoblastoma or primitive neuroectodermal tumors than medulloblastoma, CHILDS NERVOUS SYSTEM, 31巻, 6号, pp.901-pp.907, JUN 2015
  84. STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function, JOURNAL OF EXPERIMENTAL MEDICINE, 212巻, 6号, pp.855-pp.864, JUN 1 2015
  85. Mosaicism of an ELANE Mutation in an Asymptomatic Mother in a Familial Case of Cyclic Neutropenia, JOURNAL OF CLINICAL IMMUNOLOGY, 35巻, 5号, pp.512-pp.516, JUL 2015
  86. IMMUNODEFICIENCIES Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations, SCIENCE, 349巻, 6248号, pp.606-pp.613, AUG 7 2015
  87. Perceived Parenting Mediates Serotonin Transporter Gene (5-HTTLPR) and Neural System Function during Facial Recognition: A Pilot Study, PLOS ONE, 10巻, 9号, SEP 29 2015
  88. Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136巻, 4号, pp.993-pp.+, OCT 2015
  89. Remission of autoimmune neutropenia after development of Kawasaki disease, PEDIATRICS INTERNATIONAL, 57巻, 5号, pp.1012-pp.1014, OCT 2015
  90. Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia, HAEMATOLOGICA, 100巻, 12号, pp.1546-pp.1552, NOV 2015
  91. Late-onset epileptic spasms in a patient with 22q13.3 deletion syndrome, BRAIN & DEVELOPMENT, 38巻, 1号, pp.109-pp.112, JAN 2016
  92. A Patient with CTLA-4 Haploinsufficiency Presenting Gastric Cancer, JOURNAL OF CLINICAL IMMUNOLOGY, 36巻, 1号, pp.28-pp.32, JAN 2016
  93. Cavernous angioma after chemotherapy for desmoplastic/nodular medulloblastoma associated with anhidrotic ectodermal dysplasia, CHILDS NERVOUS SYSTEM, 32巻, 2号, pp.395-pp.398, FEB 2016
  94. Early eradication of factor VIII inhibitor in patients with congenital hemophilia a by immune tolrelance induction with a high dose of immunoglobulin, Intenational Journal of Hematology
  95. Significance of ACADM mutations identified through newborn screening of MCAD deficiency in Japan, MOLECULAR GENETICS AND METABOLISM, 118巻, 1号, pp.9-pp.14, MAY 2016
  96. Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype, BLOOD, 127巻, 25号, pp.3154-pp.3164, JUN 23 2016
  97. Effective Treatment of a Childhood Blastic Plasmacytoid Dendritic Cell Neoplasm with a Cutaneous Tumor Alone by Stem Cell Transplantation with Reduced Intensity Conditioning, INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 32巻, pp.S26-pp.S31, JUN 2016
  98. Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4(+) T cells into distinct effector subsets, JOURNAL OF EXPERIMENTAL MEDICINE, 213巻, 8号, pp.1589-pp.1608, JUL 25 2016



  1. 革新的がん医療実用化研究事業, 治験の実施, 2015年04月01日, 2016年03月31日
  2. 創薬基盤推進研究事業, 慢性肉芽腫症腸炎の患者選定,治験実施体制の整備,治験の実施, 2015年11月02日, 2016年03月31日
  3. 難治性疾患実用化研究事業, STATの遺伝子異常により発症する免疫不全の病態解明, 2015年04月01日, 2016年03月31日
  4. 免疫アレルギー疾患等実用化研究事業(移植医療技術開発研究分野), 原発性免疫不全症に対する造血幹細胞移植法の確立(患者登録(中四国地区統括)および造血幹細胞移植ガイドラインの評価検討), 2015年04月01日, 2016年03月31日
  5. 民間からの助成金, 先天性好中球減少症の病因・病態に関する研究, 2000年
  6. 民間からの助成金, ヒト造血幹細胞の純化と骨髄再構築能に関する研究, 1997年
  7. 難治性疾患克服研究事業, 原発性免疫不全症候群に関する調査研究, 2008年
  8. 難治性疾患克服研究事業, 先天性顆粒放出異常性の病態解明と診断法の確立, 2011年
  9. 難治性疾患克服研究事業, 先天性好球中減少症の効果的診断法の確立と治療ガイドライン作成に関する研究, 2010年
  10. 難治性疾患克服研究事業, 外胚葉形成不全免疫不全症の実態調査と治療ガイドラインの作成, 2010年
  11. がん臨床研究事業, 小児がんの羅患者数把握および晩期合併症・二次がんの実態把握のための長期フォローアップセンター構築に関する研究, 2010年
  12. 難治性疾患克服研究事業, 原発性免疫不全症候群に関する調査研究, 2005年
  13. 難治性疾患克服研究事業, Shwachman-diamond症候群の効果的診断法の確立に関する研究, 2010年
  14. 難治性疾患克服研究事業, 原発性免疫不全症に対する造血幹細胞移植法の確立, 2012年
  15. 難治性疾患克服研究事業, 原発性免疫不全に関する調査研究, 2011年
  16. 難治性疾患克服研究事業, 血液免疫系細胞分化障害による疾患の診断と治療に関する調査研究, 2012年
  17. 科学研究費助成事業(挑戦的萌芽研究), iPS細胞とヒト疾患モデルマウスを用いたSTAT1シグナル異常症の病態解析, 2014年, 2015年
  18. 科学研究費助成事業(基盤研究(B)), 人工ヌクレアーゼによる食細胞異常症由来ヒトiPS細胞の遺伝子修復に関する研究, 2013年, 2015年
  19. 科学研究費助成事業(基盤研究(C)), 食細胞異常症のヒト化マウス作製と病態解析・治療開発への応用, 2010年, 2012年
  20. 科学研究費助成事業(基盤研究(C)), 造血幹細胞表面抗原修飾による骨髄生着促進の機構解析, 2007年, 2008年
  21. 科学研究費助成事業(基盤研究(C)), 骨髄腔内への造血幹細胞輸注による移植療法確立のための基礎的研究, 2004年, 2005年
  22. 科学研究費助成事業(基盤研究(C)), ヒト骨髄中の中胚葉性幹(前駆)細胞の純化、増幅と組織再分布能, 2003年, 2004年
  23. 科学研究費助成事業(基盤研究(C)), 先天性好中球減少症をモデルとした骨髄顆粒球系細胞分化と遺伝子発現, 2001年, 2002年
  24. 科学研究費助成事業(基盤研究(C)), ヒト移植片生着促進細胞の同定と臨床応用のための基礎的研究, 2001年, 2002年
  25. 科学研究費助成事業(基盤研究(C)), 放射線感受性を調節する転写因子遺伝子に関する研究, 1999年, 2000年
  26. 科学研究費助成事業(基盤研究(C)), 共培養法によるヒト造血細胞の増幅と骨髄再構築能に関する研究, 1999年, 2000年
  27. 科学研究費助成事業(基盤研究(C)), ヒト造血前駆細胞の純化と骨髄再構築能に関する研究, 1997年, 1998年
  28. 科学研究費助成事業(一般研究(C)), 小児急性リンパ性白血病の微少残存白血病の検出に関する研究, 1993年, 1993年
  29. 科学研究費助成事業(一般研究(C)), 補体第7成分(C7)の分子遺伝学的研究, 1990年, 1990年
  30. 科学研究費助成事業(一般研究(C)), 顆粒球の機能的分化とロイコトリエン・リセプタ-、走代因子リセプタ-に関する研究, 1989年, 1989年
  31. 科学研究費助成事業(一般研究(C)), 小児悪性腫瘍細胞における癌遺伝子の形質発現に関する研究, 1986年, 1986年
  32. 厚生労働科学研究, 原発性免疫不全症に対する造血幹細胞移植法の確立, 2014年05月29日, 2015年03月31日
  33. 厚生労働科学研究, 原発性免疫不全症候群の病態解明と新規治療法開発への応用に関する研究, 2014年06月02日, 2015年03月31日
  34. 厚生労働科学研究, 高IgE症候群の病因・病態解明と新規治療法開発, 2014年06月02日, 2015年03月31日



  1. 日本小児科学会セミナー, 2005年10月
  2. 第116回日本小児科学会学術集会, 会頭, 2013年