味八木 茂SHIGERU MIYAKI

Last Updated :2019/04/01

所属・職名
病院未来医療センター 未来医療センター 講師
メールアドレス
miyakihiroshima-u.ac.jp

基本情報

主な職歴

  • 2004年03月01日, 2007年06月30日, 国立成育医療研究センター, 流動研究員
  • 2007年07月01日, 2011年03月29日, 米国スクリプス研究所, Sr. Research Accosiate
  • 2011年03月30日, 広島大学, 病院 未来医療センター, 講師

学歴

  • 筑波大学, 医学研究科, 日本, 2000年, 2004年

学位

  • 博士(医学) (筑波大学)

教育担当

  • 医学部:医学科

研究分野

  • 医歯薬学 / 外科系臨床医学 / 整形外科学

研究キーワード

  • 運動器分子生物学、変形性関節症、軟骨代謝、microRNA、エクソソーム、再生医学、腱・靭帯

所属学会

  • 国際変形性関節症学会
  • 日本再生医療学会
  • 日本軟骨代謝学会
  • 日本骨代謝学会

研究活動

学術論文(★は代表的な論文)

  1. ★, Extracellular vesicles in cartilage homeostasis and osteoarthritis, CURRENT OPINION IN RHEUMATOLOGY, 30巻, 1号, pp.129-pp.135, 201801
  2. Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes, EUROPEAN JOURNAL OF PHARMACOLOGY, 830巻, pp.1-pp.8, 20180705
  3. The delaying effect of alpha-glycerophosphocholine on senescence, transthyretin deposition, and osteoarthritis in senescence-accelerated mouse prone 8 mice, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 82巻, 4号, pp.647-pp.653, 2018
  4. IL-1 Enhances Wnt Signal by Inhibiting DKK1, INFLAMMATION, 41巻, 5号, pp.1945-pp.1954, 201810
  5. Histological Evaluation of Early-Phase Changes in the Osteochondral Unit After Microfracture in a Full-Thickness Cartilage Defect Rat Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 46巻, 12号, pp.3032-pp.3039, 201810
  6. Attenuation of cartilage degeneration by calcitonin gene-related paptide receptor antagonist via inhibition of subchondral bone sclerosis in osteoarthritis mice, JOURNAL OF ORTHOPAEDIC RESEARCH, 34巻, 7号, pp.1177-pp.1184, 201607
  7. Carnosic acid protects starvation-induced SH-SY5Y cell death through Erk1/2 and Akt pathways, autophagy, and FoxO3a, INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 67巻, 8号, pp.977-pp.982, 2016
  8. The role of tetraspanin CD9 in osteoarthritis using three different mouse models, BIOMEDICAL RESEARCH-TOKYO, 37巻, 5号, pp.283-pp.+, 2016
  9. ★, Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model, STEM CELLS TRANSLATIONAL MEDICINE, 5巻, 12号, pp.1620-pp.1630, 201612
  10. Inhibition of microRNA-222 expression accelerates bone healing with enhancement of osteogenesis, chondrogenesis, and angiogenesis in a rat refractory fracture model, JOURNAL OF ORTHOPAEDIC SCIENCE, 21巻, 6号, pp.852-pp.858, 201611
  11. ★, Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1, ARTHRITIS RESEARCH & THERAPY, 17巻, 20151013
  12. ★, Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration, FEBS LETTERS, 589巻, 11号, pp.1257-pp.1265, 20150508
  13. ★, Exosomes from IL-1 beta stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes, ARTHRITIS RESEARCH & THERAPY, 16巻, 4号, 2014
  14. ★, Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 445巻, 2号, pp.381-pp.387, 20140307
  15. Circulating microRNAs as biomarkers for evaluating the severity of acute spinal cord injury, SPINAL CORD, 52巻, 8号, pp.596-pp.600, 201408
  16. Administration of MicroRNA-210 Promotes Spinal Cord Regeneration in Mice, SPINE, 39巻, 14号, pp.1099-pp.1107, 20140615
  17. Analysis of microRNA expression in chondrosarcoma., J Orthop Res, 20131201
  18. ★, Macro view of microRNA function in osteoarthritis, NATURE REVIEWS RHEUMATOLOGY, 8巻, 9号, pp.543-pp.552, 201209
  19. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis., Ann Rheum Dis, 20120401
  20. Anterior Cruciate Ligament Changes in Human Joint in Aging and Osteoarthritis., Arthritis and Rheumatology, 20120301
  21. Angiogenic microRNA-210 is present in cells surrounding osteonecrosis, JOURNAL OF ORTHOPAEDIC RESEARCH, 30巻, 8号, pp.1263-pp.1270, 201208
  22. The Effect of Intra-articular Injection of MicroRNA-210 on Ligament Healing in a Rat Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 40巻, 11号, pp.2470-pp.2478, 201211
  23. ★, L-Sox5 and Sox6 enhance chondrogenic miR-140 expression by strengthening dimeric Sox9 activity, J Biol Chem, 287巻, 26号, pp.22206-15, 20120601
  24. Translational suppression of atrophic regulators by miR-23a integrates resistance to skeletal muscle atrophy., J Biol Chem, 20111101
  25. DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via kruppel-like factor 15 gene expression, Lab Invest, 91巻, 2号, pp.203-pp.215, 2011
  26. ★, microRNA-140 plays dual roles both in cartilage development and homeostasis, Genes Dev, 20100601
  27. Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways., PNAS, 20100601
  28. The Mohawk homeobox gene plays a critical role in tendon differentiation by regulating type collagen Production., PNAS, 20100601
  29. A systems approach reveals that myogenesis genome network is regulated by the transcriptional repressor RP58., Developmental Cell, 20101201
  30. Tissue Neogenesis and STRO-1 Expression in Immature and Mature Articular Cartilage, J Orthop Res, 28巻, 1号, pp.96-pp.102, 2010
  31. The increased expression of histone deacetylase 7 induces matrix metalloproteinase-13 in human knee osteoarthritis., Mod Rheumatol, 20巻, 1号, pp.11-pp.17, 2010
  32. Responses of MicroRNA-124a and 223 following spinal cord injury, Spinal cord, 48巻, 3号, pp.192-pp.196, 2010
  33. ★, MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates IL-1 responses, Arthritis and Rheumatology, 20090901
  34. Retroviral vector system for fluorescent real-time monitoring of miR-133 during the course of myogenic differentiation, The International Journal of Biochemistry & Cell Biology, 20091101
  35. Expression of microRNA-146 in osteoarthritis cartilage., Arthritis and Rheumatology, 20090401
  36. Induction of apoptosis in the synovium of arthritic mice by intra-articular injection of double stranded microRNA-15a., Arthritis and Rheumatology, 20090901
  37. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis, Arthritis Res Ther, 11巻, 3号, pp.R85, 2009
  38. Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes, Exp Cell Res, 315巻, 13号, pp.2231-pp.2240, 2009
  39. A disintegrin and metalloproteinase with thorombospondin motifs-9 (ADAMTS-9) expression by chondrocytes during endochondral ossification, Arc Histol Cytol, 72巻, 3号, pp.175-pp.185, 2009
  40. ★, Expression of microRNA-146 in rheumatoid arthritis synovial tissue, Arthritis Rheum, 20080501
  41. Characterization of dental pulp stem cells of human tooth germs., J Dent Res, 87巻, 7号, pp.676-pp.681, 2008
  42. Use of the SST-REX method for the identification of genes expressed at the condensation stage of chondrogenic cell line ATDC5, J Bone Min Metab, 24号, pp.153-pp.157, 2006
  43. Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling, Biochem Biophys Res Comm, 329号, pp.381-pp.385, 2005
  44. Identification of membrane and secreted proteins in anterior cruciate ligament derived cells using “signal-sequence-trap,” a retrovirus-mediated expression screening method, Materials Sci Eng, C巻, 24号, pp.397-pp.401, 2004
  45. Basic fibroblast growth factor supports chondrogenesis of bone marrow-derived mesenchymal stem cells from patients with osteoarthritis in vitro, Materials Sci Eng, C巻, 24号, pp.403-pp.406, 2004
  46. Mechanical stretch is a down-regulatory signal for differentiation of C2C12 myogenic cells, Materials Sci Eng, C巻, 17号, pp.75-pp.78, 2001
  47. Mechanical stretch in anterior cruciate ligament derived cells regulates type I collagen and decorin expression through extracellular signal-regulated kinase ½ pathway, Materials Sci Eng, C巻, 17号, pp.91-pp.94, 2001
  48. Effect of mechanical stretch on TGF-1 expression of C2C12 myogenic cells, Materials Sci Eng, C巻, 24号, pp.387-pp.388, 2001

受賞

  1. 2009年, Arthritis National Research Foundation (USA), Grant Award
  2. 2010年, Orthopaedic Research Society (USA), The New Investigator Recognition Award
  3. 2010年, World Congress on Osteoarthritis (OARSI), Young Investigator Award
  4. 2010年, Arthritis National Research Foundation, Grant Award

社会活動

委員会等委員歴

  1. 評議員, 2015年, 日本軟骨代謝学会

学術雑誌論文査読歴

  1. Osteoarthritis and Cartilage, その他, Reviewer
  2. Arthritis Research & Therapy, その他, Reviewer
  3. Stem Cell Research & Therapy, その他, Reviewer
  4. Cell Communication and Signaling, その他, Reviewer
  5. Biochimica et Biophysica Acta (BBA)- Molecular Basis of Disease, その他, Reviewer
  6. Experimental Biology and Medicine, その他, Reviewer
  7. Journal of Experimental Orthopaedics, その他, Reviewer
  8. Scientific Reports, その他, Reviewer
  9. Biochem Biophys Res Commun., その他, Reviewer
  10. Molecular Therapy, その他, Reviewer
  11. Journal of Orthopaedic Research, その他, Reviewer
  12. Food & Function, その他, Reviewer