宮内 睦美Mutsumi Miyauchi

Last Updated :2019/11/07

所属・職名
大学院医系科学研究科(歯)(歯学)口腔顎顔面病理病態学教授
メールアドレス
mmiyahiroshima-u.ac.jp

基本情報

主な職歴

  • 1984年05月01日, 2001年07月31日, 広島大学, 助手
  • 2001年08月01日, 2007年04月01日, 広島大学, 助教授
  • 2007年04月01日, 2019年03月31日, 広島大学, 准教授

学位

  • 博士(歯学)(広島大学)

研究分野

  • 医歯薬学 / 歯学 / 形態系基礎歯科学

研究キーワード

  • ラクトフェリン
  • ポルフィロモナス ジンジバリス
  • 非アルコール性脂肪性肝炎/NASH
  • バイオマーカー / 早産
  • 歯周炎
  • γ-GTP
  • 全身疾患

教育活動

授業担当

  1. 2019年, 学部専門, 2ターム, 歯周病学
  2. 2019年, 学部専門, 1ターム, 歯学研究特論I
  3. 2019年, 学部専門, 4ターム, 歯学概論
  4. 2019年, 学部専門, 3ターム, 口腔病理学I
  5. 2019年, 学部専門, 4ターム, 口腔病理学II
  6. 2019年, 学部専門, 1ターム, 口腔病理学実習I
  7. 2019年, 学部専門, 2ターム, 口腔病理学実習II
  8. 2019年, 学部専門, 集中, 口腔顎顔面病理病態学実習
  9. 2019年, 学部専門, 集中, 口腔顎顔面病理病態学実習
  10. 2019年, 学部専門, 集中, 口腔顎顔面病理病態学実習
  11. 2019年, 学部専門, 2ターム, 病理学・口腔病理学
  12. 2019年, 学部専門, 2ターム, 基礎オーラルサイエンス実習
  13. 2019年, 学部専門, 2ターム, 病理学・口腔病理学
  14. 2019年, 修士課程・博士課程前期, セメスター(後期), 病因病態学
  15. 2019年, 修士課程・博士課程前期, セメスター(前期), 医歯科学演習(口腔顎顔面病理病態学)
  16. 2019年, 修士課程・博士課程前期, セメスター(後期), 医歯科学演習(口腔顎顔面病理病態学)
  17. 2019年, 修士課程・博士課程前期, セメスター(前期), 医歯科学特別研究(口腔顎顔面病理病態学)
  18. 2019年, 修士課程・博士課程前期, セメスター(後期), 医歯科学特別研究(口腔顎顔面病理病態学)
  19. 2019年, 博士課程・博士課程後期, セメスター(前期), 口腔顎顔面病理病態学特別演習
  20. 2019年, 博士課程・博士課程後期, セメスター(後期), 口腔顎顔面病理病態学特別演習
  21. 2019年, 博士課程・博士課程後期, セメスター(前期), 口腔顎顔面病理病態学特別実験
  22. 2019年, 博士課程・博士課程後期, セメスター(後期), 口腔顎顔面病理病態学特別実験
  23. 2019年, 修士課程・博士課程前期, セメスター(後期), 病因病態学
  24. 2019年, 博士課程・博士課程後期, セメスター(前期), 口腔顎顔面病理病態学特別演習
  25. 2019年, 博士課程・博士課程後期, セメスター(後期), 口腔顎顔面病理病態学特別演習
  26. 2019年, 博士課程・博士課程後期, セメスター(前期), 口腔顎顔面病理病態学特別研究
  27. 2019年, 博士課程・博士課程後期, セメスター(後期), 口腔顎顔面病理病態学特別研究

研究活動

学術論文(★は代表的な論文)

  1. 唾液腺腫瘍の免疫組織化学的研究 Ⅰ.正常ヒト唾液腺における各種分泌上皮性マーカーの局在について., 26巻, pp. 1190-1199, 19840401
  2. 唾液腺腫瘍の免疫組織化学的研究 Ⅱ.各種良性腫瘍における分泌上皮性マーカーの局在について., 26巻, pp. 1200-1209, 19840401
  3. 唾液腺腫瘍の免疫組織化学的研究 Ⅲ.各種悪性腫瘍における分泌上皮性マーカーの局在について., 27巻, pp. 611-620, 19850401
  4. 形態学的にLennert病変を伴う悪性リンパ腫と考えられ,免疫組織化学的にB細胞の多クローン性増生が証明された1症例, 病理と臨床, 5巻, pp. 3, 19870401
  5. ラット各種臓器におけるリソチームの免疫組織化学的証明に関する研究, 広島大学歯学雑誌, 20巻, pp. 2, 19880401
  6. ラット臼歯部歯肉接合上皮細胞の異物貪食能について -超微形態学的研究-., 30巻, pp. 397-408, 19880401
  7. Morphological change in rat periodontium induced by the topical application of lipopolysaccharide, Recent Acvances in Clinical Periodontology, 19880401
  8. リポポリサッカライドと歯槽骨吸収, 広島大学歯学雑誌, 21巻, pp. 2, 19890401
  9. Lectin binding of rat gingival epithelia., J. Periodont. Res., pp. 25, 151-155, 19900401
  10. Demographic study of 383 cases of intra-oral minor salivary gland tumors, 5th International Congress of the International association of Oral Pathologists, 19900401
  11. Spitz Nevus of the palate, Oral Surg Oral Med Oral Pathol, 69巻, pp. 603-605, 19900401
  12. Immunohistochemical and ultrastructural characterization of subcultured epithelial cells derived from clear cell tumor of palatal gland origin, Japanese Tissue Culture Society for Dental Research, 27巻, pp. 1-4, 19900401
  13. The cellular composition of basal cell adenoma of parotid gland : An immunohistochemical analysis., Oral Surg Oral Med Oral Pathol, 70巻, pp. 619-626, 19900401
  14. A comparative immunohistochemical study of ameloblastoma and odontogenic cysts, 19900401
  15. Clear cell tumors of minor salivary gland origin: An immunohistochemical and ultrastructural analysis., Oral Surg Oral Med Oral Pathol, 72巻, pp. 200-207, 19910401
  16. Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases, Virchows Archiv. A, 419巻, pp. 177-182, 19910401
  17. ★, Effect of exogenously applied prostaglandin E2 on alveolar bone loss, Journal of Periodontology, 63巻, pp. 405-411, 19920401
  18. Enhanced collagen phagocytosis by rat molar periodontal fibroblasts after topical application of lipopolysaccharide -Ultrastructural observation and morphometric analysis., J. Periodont. Res., 27巻, pp. 167-175, 19920401
  19. Proliferating cell nuclear antigen (PCNA) as a marker of proliferating cells in salivary gland tumors., Jpn. J. Oral Biol., 34巻, pp. 454-457, 19920401
  20. ★, LPS投与後のラット辺緑歯周組織におけるマクロファ-ジ系細胞の動態にについて-免疫組織化学的検討-, 19930401
  21. 顎関節に発生した滑膜性軟骨肉腫の1症例, 日本病理学会会誌, 83巻, pp. 193, 19940401
  22. Prognostic implication of low molecular weight cytokeratin expression in oral squaomus cell carcinoma, Oral Oncology, 4B巻, pp. 175-178, 19950401
  23. IL-1αin produced by oral squamous carcinoma cell lines and stimulates their growth, Oral Oncology, 4B巻, pp. 324-327, 19950401
  24. Correlation between argyrophilic nucleolar organizer region (AgNOR) counts and histologic grades with respect to biologic behavior of salivary adenoid cystic carcinoma, Journal of Oral Pathology & Medicine, 24巻, pp. 437-442, 19950401
  25. Florid cemento-osseous dysplasia with concomitant simple bone cysts, Journal of Oral Pathology & Medicine, 24巻, pp. 285-287, 19950401
  26. Immunohistochemical observations on a possible ameloblastic fibro-odontoma, Journal of Oral Pathology & Medicine, 25巻, pp. 93-96, 19960401
  27. Immunohistochemical detection of prostaglandins E2, F2a,and 6-keto-prostaglandin F1a in experimentally induced periapical inflammatory lesions in rats., J. Endodont., 22巻, pp. 635-637, 19961201
  28. Immunohistochemical demonstration of prostaglandins E2, F2α, and 6-keto-prostaglandin F1αin rat dental pulp with experientally induced inflammation, Journal of Endodontics, 22巻, pp. 600-602, 19960401
  29. Immunohistochemical demonstration of prostaglandins in various tissues of the rat, The International Journal of Biochemistry & Cell Biology, 105巻, pp. 27-31, 19960401
  30. nm23-H1 expression in salivary adenoid cystic carcinoma in relation to metastasis and survival, Oncology Reports, 4巻, pp. 707-711, 19970401
  31. Partial resection of the mandible for the treatment of diffuse sclerosing osteomyelitis:Report of four cases, J Oral Maxillofac Surg, 55巻, pp. 410-414, 19970101
  32. Two malignant myoepitheliomas of intraoral minor salivary glands, 13th Int. Conference on Oral Maxillofac. Surg., 19970401
  33. ★, Reactive change in proliferative activity of the junctional epithelium after topical application of lip opolysaccharide., J. Periodontol, 68巻, pp. 531-535, 19970401
  34. Initial attachment of osteoblasts to various GTR membrane, J. Dental Res., 19970401
  35. Reduced Expression of Cyclin-dependent Kinase Inhibitor p27Kip1 is an Indicator of Malignant Behavior of Oral Squamous Cell Carcinomas, Cancer, 83巻, pp. 2447-2466, 19980401
  36. Distribution of macrophage lineage cells in rat gingival tissue after topical application of lipopolysaccharide: an immunohistochemical study using monoclonal antibodies: OX6, ED1 and ED2., Journal of Periodontal Research, 33巻, pp. 345-351, 19980401
  37. Three-dimensional appearance of Langerhans cells in human gingival epithelium as revealed by confocal laser scanning microscopy, Arch. Oral Biol., 43巻, pp. 741-744, 19980401
  38. Polymorphous low-grade adenocarcinoma of the upper lip, oral Med Pathol, 3巻, pp. 115, 19980401
  39. Localization of glycosaminoglycans (GAGs) in pleomorphic adenoma (PA) of salivary glands:an immunohistochemical and histochemical evaluation., J Oral Pathol Med, 27巻, pp. 272-277, 19980401
  40. Clear cell odontogenic tumour: a case with induction of dentin-like structures?, J Oral Pathol Med, 27巻, pp. 220-224, 19980401
  41. Synovial chondrosarcoma arising in the temporomandibular joint., J Oral Maxillofac Surg, 56巻, pp. 890-894, 19980401
  42. Periodontium cells proliferation and differentiation on various GTR membrane, J. Dental Res., 77巻, 19980401
  43. 口腔癌の放射線治療後に発生した悪性線維性組織球腫, 病院病理, 16巻, pp. 19, 19980401
  44. Clinical and histopathological analyses of desmoplastic ameloblastoma, Pathology Research and Practice, 195巻, pp. 669-675, 19990401
  45. 口腔扁平上皮癌におけるプロテアソームによるp27Kip1タンパクの分解, 口腔組織培養研究会誌, 7巻, pp. 79-80, 19980401
  46. 線維形成性エナメル上皮腫における トランフ フォーシンブ成長因子βの免疫組織化学的発現, Virchows Archie, 436巻, pp. 319-323, 19990401
  47. Migration of osteoblastic cells on various GTR/GBR membranes., J. Dental Res., 78巻, 19990401
  48. 細胞周期と口腔癌, 広島大学歯学雑誌, 31巻, pp. 183-185, 19990401
  49. Immunohistochemical and histochemical characterization of the mucosubstances of odontogenic myxoma, Pathology Reseach and Practice, 195巻, pp. 391-397, 19990401
  50. Periodontitis in the house musk shrew (Suncus murinus) : A potential animal model for human periodontal disease., J. Periodontol, 70巻, pp. 195-200, 19990401
  51. So-called ’hybrid’ lesion of desmopla Stic and convertional ameloblastoma : Report of a case and review of the literature, Pathology International, 49巻, pp. 1014-1018, 19990401
  52. Reduced expression of p27Kip1 protein in relation to salivary adenoid cystic carcinoma metastasis, Cancer, 86巻, pp. 928-835, 19990401
  53. Reduced expression of CD44 variant 9 is related to lymph node metastasis and poor survival in squamous cell carcinoma of tongue, Oral Oncology, 36巻, pp. 545-549, 20000401
  54. 生検診断が困難であった舌下腺部 solitary fibrous tumor の1例, 日本唾液腺学会誌, 41巻, pp. 23-24, 20000401
  55. CD44v9 発現減弱の舌扁平上皮癌におけるリンパ節転移と予後との関係, Oral Oncology, 36巻, pp. 545-549, 20000401
  56. Immunoexpression of transforming growth factor β in desmoplastic ameloblastoma, Virchows arch, 436巻, pp. 319-323, 20000401
  57. Reduced expression of p27Kip1 correlates with and early stage of cancer invasion in Oral Squamous cell carcinoma, Cancer Letters, 151巻, pp. 217-222, 20000401
  58. p279(Kip1) accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells, CLINICAL CANCER RESEARCH, 6巻, 3号, pp. 916-923, 200003
  59. “Malignant pleomorphic adenoma”in the palate, Oral Medicine Pathology, 5巻, pp. 49-52, 20000401
  60. Proliferation and differentiation of periodontal ligament cells on various GTR membranes., International Congress= International Association of Oral Pathologists, pp. 20, 20000801
  61. 腺様嚢胞癌におけるp27Kip1タンパク発現低下の臨床的意義とその機序, 日本唾液腺学会誌, 41巻, pp. 64-66, 20000401
  62. 腺様嚢胞癌様の組織像を広範に伴った多形性腺腫の1例, 日本唾液腺学会誌, 2001巻, pp. 21-24, 20010401
  63. Effects of enamel matrix derivative on proliferation and differentiation of periodontal cells, J. Dental Res., 80巻, pp. 771, 20010601
  64. Migration of osteoblastic cells on various guided bone regeneration membranes, CLINICAL ORAL IMPLANTS RESEARCH, 12巻, 4号, pp. 332-338, 200108
  65. High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas, Cancer Research, 61巻, 19号, pp. 7044-7047, 20010401
  66. Attachment, proliferation and differentiation of periodontal ligament cells on various GTR membranes., J. Periodont. Res., 35巻, pp. 1-6, 20010401
  67. Roles of CD14 in LPS-induced periodontal tissue responses, J. Dental Res., 80巻, pp. 768, 20010601
  68. 口腔小唾液腺の悪性筋上皮腫の2例 -悪性転化の推定された例-, 日本口腔外科学会雑誌, 47巻, 3号, pp. 170-173, 20010301
  69. Cytokine expression in rat molar gingival periodontal tissues after topical application of lipopolysaccharide, Histochem Cell Biol, 116巻, pp. 57-62, 20010401
  70. Initial attachment of osteoblasts to various guided bone regeneration membranes: An in vitro study., Journal of Periodontal Research, 37巻, pp. 340-344, 20020401
  71. Establishment of human cementifying fibroma cell lines by transfection with temperature-sensitive simian virus-40 T-antigen gene and hTERT gene., BONE, 30巻, pp. 712-717, 20020401
  72. Transfection of p27Kip1 threonine residue 187 mutant type gene, which is not influenced by ubiquitin-mediated degradation, induces cell cycle arrest in oral squamous cell carcinoma cells., Oncology, 63巻, pp. 398-404, 20020401
  73. ポケット形成のメカニズム, クインッテッセンス, 21巻, pp. 3-16, 20020401
  74. Cementum: A phosphate-sensitive tissue, JOURNAL OF DENTAL RESEARCH, 81巻, 12号, pp. 817-821, 200212
  75. Clear cell odontogenic carcinoma with ghost cells and inductive dentin formation - report of a case in the mandible, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 31巻, 3号, pp. 181-183, MAR 2002
  76. Pleomorphic adenoma with extensive adenoid cystic carcinoma-like cribriform areas of parotid gland, Pathology International, 53巻, pp. 30-34, 20030401
  77. Solitary fibrous tumor with malignant potential arising in sublingual gland., Pathology International, 53巻, pp. 40-45, 20030401
  78. Dedifferentiated malignant myoepithelioma of the parotid gland, Pathology International, 53巻, pp. 704-709, 20030401
  79. Establishment of an oral squamous cell carcinoma cell line with high invasive and p27 degradation activity from lymph node metastasis, Oral Oncology, 39巻, pp. 515-520, 20030401
  80. Establishment of human cementifying fibroma cell lines by transfection with temperature-sensitive simian virus-40 T-antigen gene and hTERT gene, BONE, 30巻, 5号, pp. 712-717, 200205
  81. 脱分化型唾液腺腫瘍の2例, 日本唾液腺学会誌, 44巻, pp. 30-32, 20030401
  82. Dedifferentiated malignant myoepithelioma of the parotid gland, PATHOLOGY INTERNATIONAL, 53巻, 10号, pp. 704-709, OCT 2003
  83. Inhibition of CD44v9 upregulates the invasion ability of oral squamous cell carcinoma cells., Oral Oncology, 39巻, pp. 27-30, 20030401
  84. Immuno-localization of COX-1 and COX-2 in the rat molar periodontal tissue after topical application of lipopolysaccharide., Archives of Oral biology, 49巻, pp. 739-746, 20040401
  85. ★, Immunolocalization of CXC chemokine and recruitment of polymorphonuclear leukocytes in the rat molar periodontal tissue after topical application of lipopolysaccharide., Histochemistry and Cell Biology, 121巻, pp. 291-297, 20040401
  86. Studies on the novel gene diagnosis and therapy targeting p27 and its related factors for oral malignancies., Journal of Oral Biosciences, 46巻, pp. 97-106, 20040401
  87. Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-cell lines., Infection and Immunity, 72巻, pp. 871-879,, 20040401
  88. Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous beta-catenin., Clinical Cancer Research, 10巻, pp. 5455-5463, 20040401
  89. Influence of additive hyaluronic acid on the lubricating ability in the temporomandibular joint., Journal of Biomedical Materials Research Part A, 70A,巻, pp. 149-153, 20040401
  90. Immunolocalization of vascular endothelial growth factor in rat condylar cartilage during postnatal development, Histochemistry and Cell Biology, 122巻, pp. 35-40, 20040401
  91. Lesion in the maxilla with a multicystic appearance, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 62巻, 10号, pp. 1264-1268, OCT 2004
  92. Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation., American Journal of Pathology, 165巻, pp. 2147-2155, 20040401
  93. Upregulated CD44v9 expression inhibits the invasion of oral squamous cell carcinoma cells., Pathobiology, 71巻, pp. 171-175, 20040401
  94. ガマ腫様の臨床病態を呈したcongenital teratoid cystの1例, 日本唾液腺学会, 45巻, pp. 41-42, 20040401
  95. Establishment of cementoblast cell lines from rat cementum lining cells by transfection with temperature-sensitive simian virus-40 T-antigen gene., BONE, 37巻, pp. 220-226, 20050401
  96. Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis., Oncogene, 24巻, 6号, pp. 1122-1127, 20050401
  97. 広範にpapillary-cysticな組織構築を示し,細胞異型の明瞭な領域を伴った耳下腺原発上皮-筋上皮癌の1例, 診断病理, 22巻, 1号, pp. 231-234, 20050120
  98. 歯原性腫瘍の病理診断, 病理と臨床, 23巻, pp. 1186-1193, 20050401
  99. Down-regulation of Cdk inhibitor p27 in oral squamous cell carcinoma., Oral Oncology, 41巻, 2号, pp. 105-116, 20050201
  100. Small interfering RNA targeting of S phase kinase-interacting protein 2 inhibits cell growth of oral cancer cells by inhibiting p27 degradation., Molecular Cancer Therapy, 4巻, pp. 471-476, 20050401
  101. Vascular endothelial growth factor plays an important autocrine/paracrine role in the progression of osteoarthritis, HISTOCHEMISTRY AND CELL BIOLOGY, 123巻, 3号, pp. 275-281, 200503
  102. Characteristics of periodontal ligament subpopulations obtained by sequential enzymatic digestion of rat molar periodontal ligament., BONE, 38巻, pp. 420-426, 20060401
  103. Degradation of cyclin-dependent kinase inhibitor p27 in oral cancer, Oral Pathology and Medicine, 11巻, pp. 19-26, 20060401
  104. Establishment and characterization of a spindle cell squamous carcinoma cell line, Journal of Oral Pathology and Medicine, 35巻, pp. 479-483, 20060401
  105. Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer, Cancer Research, 66巻, pp. 6928-6935, 20060401
  106. Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer, British Journal of Cancer, 95巻, 10号, pp. 1396-1403, 20060401
  107. Effects of endogenous and exogenous prostaglandin E2 on the proliferation and differentiation of a mouse cementoblast cell line (OCCM-30)., Journal of Preiodontology, 77巻, 12号, pp. 2051-2058, 20061201
  108. Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 349巻, 3号, pp. 1050-1056, 20061027
  109. Effects of ultrasound on cementoblast metabolism in vitro., Ultrasound in Medicine & Biology, 32巻, 6号, pp. 943-948, 20060601
  110. The effect of removal of the disc on the friction in the temporomandibular joint, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 64巻, 8号, pp. 1221-1224, 200608
  111. Characterization of established cementoblast-like cell lines from human cementum lining cells in vitro and in vivo., Bone, 39巻, 5号, pp. 1035-1042, 20061101
  112. Platelet-derived growth factor enhances proliferation and matrix synthesis of temporomandibular joint disc-derived cells, ANGLE ORTHODONTIST, 76巻, 3号, pp. 486-492, 200605
  113. PGE2 activates cementoclastogenesis by cementoblasts via EP4., Journal of Dental Research, 86巻, 10号, pp. 974-979, 20071001
  114. Immortalization and characterization of human dental pulp cells with odontoblastic differentiation., Archives of Oral Biology, 52巻, 8号, pp. 727-731, 20070801
  115. Chronic administration of lipopolysaccharide and proteases induces periodontal inflammation and hepatic steatosis in rats, JOURNAL OF PERIODONTOLOGY, 78巻, 10号, pp. 1999-2006, 200710
  116. Cyclooxygenase-2-dependent prostaglandin E2 up-regulates interleukin (IL)-1a-induced IL-6 generation in mouse cementoblasts., Journal of Periodontology, 78巻, 1号, pp. 135-140, 20070101
  117. Immortalization and characterization of pleomorphic adenoma cells by transfection with the hTERT gene., International Journal Of Oncology, 31巻, 2号, pp. 339-344, 20070801
  118. Treatment with anti-gamma-glutamyl transpeptidase antibody attenuates osteolysis in collagen-induced arthritis mice, JOURNAL OF BONE AND MINERAL RESEARCH, 22巻, 12号, pp. 1933-1942, 200712
  119. Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer, Virchows Archiv, 450巻, 3号, pp. 297-302, 20070401
  120. Enamel Matrix Derivative Exhibits Anti-inflammation Properties in Monocytes., J Periodontol, 79巻, 3号, pp. 535-540, 20080301
  121. Cementoblast response to low- and high-intensity ultrasound., Archives of Oral Biology, 53巻, 4号, pp. 318-323, 20080401
  122. Effects of ultrasound on the proliferation and differentiation of cementoblast lineage cells, Journal of Periodontology, 79巻, 10号, pp. 1984-1990, 20081001
  123. Effects of Ultrasound on the Proliferation and Differentiation of Cementoblast Lineage Cells, JOURNAL OF PERIODONTOLOGY, 79巻, 10号, pp. 1984-1990, 200810
  124. Prostaglandin E2 inhibits mineralization and enhances matrix metalloproteinase-13 in mature cementoblasts mainly via the EP4 pathway., Archives of Oral Biology, 53巻, 3号, pp. 243-249, 20080301
  125. 著明な脂肪化を伴った頬部血管平滑筋腫の1例., 日口外誌, 54巻, pp. 621-625, 20081201
  126. 大豆レシチンによるリポソーム化ラクトフェリン経口投与がリポポリサッカライド誘導歯周組織破壊に及ぼす抑制効果, ラクトフェリン2009, pp. 79-83, 20090801
  127. Effects of improvement in periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats, ACTA ODONTOLOGICA SCANDINAVICA, 67巻, 4号, pp. 200-205, 200907
  128. Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis., Biochem Biophys Res Commun, 393巻, 4号, pp. 800-805, 20100301
  129. Ultrasound stimulation induces PGE(2) synthesis promoting cementoblastic differentiation through EP2/EP4 receptor pathway., Ultrasound Med Biol, 36巻, 6号, pp. 907-915, 20100601
  130. Inhibitory effects of orally administrated liposomal bovine lactoferrin on the LPS-induced osteoclastogenesis, Lab Invest, 90巻, 8号, pp. 1236-46, 20100801
  131. 大豆レシチンリポソーム化ラクトフェリンの抗炎症効果 人為的な歯の移動時の炎症制御への応用, DENTAL DIAMOND, 36巻, 16号, pp. 68-71, 20111201
  132. Effect of PGE2 induced by compressive and tensile stresses on cementoblast differentiation in vitro., Arch Oral Biol, 56巻, 11号, pp. 1238-46, 20111101
  133. Synthetic ameloblastin peptide stimulates differentiation of human periodontal ligament cells., Archives Oral Biology, 56巻, 4号, pp. 376-9, 20110301
  134. Ameloblastin Regulates Osteogenic Differentiation by Inhibiting Src Kinase via Cross Talk between Integrin beta 1 and CD63, MOLECULAR AND CELLULAR BIOLOGY, 31巻, 4号, pp. 783-792, 201102
  135. Amelogenin enhances the proliferation of cementoblast lineage cells., J Periodontol, 82巻, 11号, pp. 1632-8, 20111101
  136. Ultrasound stimulation attenuates root resorption of rat replanted molars and impairs tumor necrosis factor-α signaling in vitro., J Periodontal Res, 46巻, 6号, pp. 648-54, 20111201
  137. Topical application of Aggregatibacter actinomycetemcomitans CDT induces cell cycle arrest in the rat gingival epithelium in vivo., Journal of Periodontal Research, 46巻, pp. 389-395, 20110401
  138. Differential Effects of Amelogenin on Mineralization of Cementoblasts and Periodontal Ligament Cells, JOURNAL OF PERIODONTOLOGY, 83巻, 5号, pp. 672-679, 201205
  139. F-spondin regulates the differentiation of human cementoblast-like (HCEM) cells via BMP7 expression, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 418巻, 2号, pp. 229-233, 20120210
  140. Oral Administration of Prostaglandin E-2-Specific Receptor 4 Antagonist Inhibits Lipopolysaccharide-Induced Osteoclastogenesis in Rat Periodontal Tissue, JOURNAL OF PERIODONTOLOGY, 83巻, 4号, pp. 506-513, 201204
  141. Molecular Mechanisms of the Inhibitory Effects of Bovine Lactoferrin on Lipopolysaccharide-mediated Osteoclastogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 287巻, 28号, pp. 23527-23536, 20120706
  142. Multiple cemental tears, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 114巻, 3号, pp. 365-372, SEP 2012
  143. Protein Kinase A-Dependent Substance P Expression by Pituitary Adenylate Cyclase-Activating Polypeptide in Rat Sensory Neuronal Cell Line ND7/23 Cells, JOURNAL OF MOLECULAR NEUROSCIENCE, 48巻, 3号, pp. 541-549, 201211
  144. Lipopolysaccharide induces rapid loss of follicular dendritic cell-secreted protein in the junctional epithelium, JOURNAL OF PERIODONTAL RESEARCH, 47巻, 6号, pp. 689-694, 201212
  145. Ultrasound stimulation attenuates resorption of tooth root induced by experimental force application, BONE, 53巻, 2号, pp. 497-506, 201304
  146. The FGFR1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP-1, BRITISH JOURNAL OF CANCER, 109巻, 8号, pp. 2248-2258, 20131015
  147. ★, Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice, JOURNAL OF GASTROENTEROLOGY, 48巻, 11号, pp. 1259-1270, 201311
  148. Orally Administered Liposomal Lactoferrin Inhibits Inflammation-Related Bone Breakdown Without Interrupting Orthodontic Tooth Movement, JOURNAL OF PERIODONTOLOGY, 84巻, 10号, pp. 1454-1462, 201310
  149. Lactoferrin inhibits infection-related osteoclastogenesis without interrupting compressive force-related osteoclastogenesis, ARCHIVES OF ORAL BIOLOGY, 59巻, 2号, pp. 226-232, 20140201
  150. Infection with Porphyromonas gingivalis Exacerbates Endothelial Injury in Obese Mice, PLOS ONE, 9巻, 10号, 20141024
  151. 上顎に発生した粘液線維肉腫の1例, 日口外誌, 60巻, 6号, pp. 354-358, 20140620
  152. 歯性感染はメタボリックシンドロームの病態に悪影響を及ぼす, 歯界月報, 20140201
  153. ★, Dental Infection of Porphyromonas gingivalis Induces Preterm Birth in Mice., PLoS One., 20150831
  154. ★, Osteodystrophy in Cholestatic Liver Diseases Is Attenuated by Anti-γ-Glutamyl Transpeptidase Antibody., PLoS One., 10巻, 9号, 20150915
  155. 上顎に発生した粘液線維肉腫の1例, 日本口腔外科学会雑誌, 60巻, 6号, pp. 354-358, 20140921
  156. Enhanced Expression of Contractile-Associated Proteins and Ion Channels in Preterm Delivery Model Mice With Chronic Odontogenic Porphyromonas Gingivalis Infection., Reprod Sci., 20151220
  157. Morbidly obese patient with non-alcoholic steatohepatitis-related cirrhosis who died from sepsis caused by dental infection of Porphyromonas gingivalis: A case report, HEPATOLOGY RESEARCH, 46巻, 3号, pp. E210-E215, 201603
  158. Bisphosphonate-related osteonecrosis of the jaw successfully treated with surgical resection and its histopathological features: A long-term follow-up report, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 27巻, 2号, pp. 283-286, 20150301
  159. Effects of C-Terminal Amelogenin Peptide on Proliferation of Human Cementoblast Lineage Cells, JOURNAL OF PERIODONTOLOGY, 87巻, 7号, pp. 820-827, 201607
  160. チタンメッシュトレーと自家腸骨 海綿骨細片による下顎骨再建とインプラント治療を行った歯原性粘液線維腫の1例, 日本口腔科学会雑誌, 60巻, 3号, pp. 269-275, 20150301
  161. 内部に洞粘膜の陥入を認めた大きな上顎洞骨腫の1例, 日本口腔外科学会雑誌, 61巻, 12号, pp. 673-677, 20151201
  162. 歯周病原細菌と非アルコール性脂肪性肝炎のかかわり, MEDICAL TECHNOLOGY, 43巻, 9号, pp. 902-904, SEP 1 2015
  163. Human odontogenic epithelial cells derived from epithelial rests of Malassez possess stem cell properties, LABORATORY INVESTIGATION, 96巻, 10号, pp. 1063-1075, 201610
  164. γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis., Scientific Reports, 201610
  165. N-terminal region of human ameloblastin synthetic peptide promotes bone formation, ODONTOLOGY, 105巻, 1号, pp. 116-121, 201701
  166. A case of primordial odontogenic tumor: A new entity in the latest WHO classification (2017), PATHOLOGY INTERNATIONAL, 67巻, 7号, pp. 365-369, 201707
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  170. Inhibition of DMH-DSS-induced colorectal cancer by liposomal bovine lactoferrin in rats, ONCOLOGY LETTERS, 14巻, 5号, pp. 5688-5694, 201711
  171. Bovine lactoferrin reduces extra-territorial facial allodynia/hyperalgesia following a trigeminal nerve injury in the rat., Brain Res., 1669巻, pp. 89-96, 20170815
  172. Tissue inhibitor of metalloproteinase-1 promotes cell proliferation through YAP/TAZ activation in cancer, ONCOGENE, 37巻, 2号, pp. 263-270, 20180111
  173. Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma, PLOS ONE, 13巻, 1号, 20180130
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著書等出版物

  1. 2006年03月, 辺縁歯周組織の病変;口腔病理アトラス(高木 実監修,山本浩嗣,坂井英隆,高田 隆編) , 文光堂, 2006年, 03, 単行本(学術書), 共編著, 亀山洋一郎 田中明男 , ISBN483067, 358
  2. 2008年, 歯周病学の視点からみた国民の健康増進:歯肉出血の発症機序と全身疾患との関係, 医歯薬出版株式会社, 2008年, 共著, 116-119
  3. 2008年, 外科病理マニュアル 各論 2.歯・顎骨, 病理と臨床 臨時増刊号 26, 2008年, 共著, 139-143
  4. 2008年, 辺縁歯周組織の病変;新口腔病理学(下野正基,高田 隆編), 医歯薬出版株式会社, 2008年, 共著, 84-103
  5. 2008年-0月, ラクトフェリンと歯周病, 広島大学歯学雑誌, 宮内 睦美;山野 栄三;高田 隆
  6. 2015年, 病理診断クイックリファレンス, 顆粒細胞腫,歯根嚢胞,腺腫様歯原性腫瘍,石灰化上皮性歯原性腫瘍, 単行本(学術書)
  7. 2015年, 腫瘍病理鑑別診断アトラス 頭頸部腫瘍Ⅱ(森永正二郎,髙田 隆,長尾俊孝編集), セメント芽細胞腫,骨形成線維腫,線維性異形成症

招待講演、口頭・ポスター発表等

  1. Porphyromonas gingivalis の歯性感染は非アルコール性脂肪性肝炎(NASH)の病態を増悪する, 宮内睦美, 古庄寿子, 坂本真一, 應原和久, 栗原英見, 高田 隆, 日本歯周病学会60周年記念京都大会, 2017年12月16日, 招待, 日本語, 日本歯周病学会, 京都
  2. Dental infection of Porphyromonas gingivalis induces preterm birth through Galectin-3, Miyauchi M., Urabe S., Konishi H., Miyoshi H., Kudo Y., Takata T., 第69回日本産科婦人科学会, 2017年04月14日, 通常, 英語
  3. アジアにおける歯原性腫瘍の実態に関する大規模共同調査研究, 髙田 隆,仙波伊知郎,前田初彦,武田泰典,熊本裕行,久山佳代, 豊澤 悟,長塚 仁,宮内睦美,小川郁子, 第106回日本病理学総会, 2017年04月28日, 通常, 日本語, 東京
  4. Porphyromonas gingivalis 歯性感染は肝星細胞を活性化し、非アルコール性脂肪性肝炎の病態を増悪する, 宮内睦美,長﨑敦洋,坂本真一,古庄寿子,髙田 隆, 第60回 春季日本歯周病学会学術大会, 2017年05月12日, 通常, 日本語, 博多
  5. The transition of tissue inhibitor of etalloproteinase-1 and -4 expressions induces aggressive behavior and poor patient survival in dedifferentiated  liposarcoma via YAP/TAZ activation, Shrestha M., Ando T., Ogawa I., Miyauchi M., Takata T., 第50回広島大学歯学会, 2017年06月17日, 通常, 英語
  6. Galectin-3 is possible predictive / diagnostic biomarker of spontaneous preterm birth caused by placental infection:, Chou K., Miyauchi M., Furusho H., Sakamoto S., Takata T., 第65回国際歯科研究学会日本部会 (JADR)総会・学術大会, 2017年12月17日, 通常, 英語, 東京
  7. The transition of tissue inhibitor of metalloproteinase-4 to -1 expression modulates YAP/TAZ mediated aggressive phenotype in liposarcoma, Shrestha M, Ando T, Ogawa I, Miyauchi M, Takata T, Joint International Association of Oral Pathology and American Academy of Oral & Maxillofacial Pathology Meeting, 2018年06月22日, 通常, 英語, Vancouver
  8. Porphyromonas gingivalis-odontogenic infection promotes development/progression of nonalcoholic steatohepatitis-related hepatocellular carcinoma, Sakamoto S, Furusho H, Shrestha M, Miyauchi M, Takata T, 96th General Session & Exhibition of the IADR, 2018年07月25日, 通常, 英語, London
  9. Suppression of Galectin-3 prevent preterm-birth by Porphyromonas gingivalis odontogenic infection, Furusho H, Miyauchi M, Konishi H, Urabe S, Kudo Y, Takata T, International Federation of Placenta Associations (IFPA), 2018年09月21日, 通常, 英語, Tokyo
  10. The transition of tissue inhibitor of metalloproteinase-1 and -4 expressions induces aggressive behavior and poor patient survival in dedifferentiated liposarcoma via YAP/TAZ activation, Shrestha M, Ando T, Chanbora C, Ogawa I, Miyauchi M, Takata T:, 7th Hiroshima Conference on Education and Science in Dentistry, 2018年03月29日, 通常, 英語, Hiroshima
  11. Development of a prognostic / diagnostic examination system of preterm delivery, targeting serum galectin-3:, Urabe S, Konishi H, Teraoka Y, Miyoshi H, Miyauchi M, Takata T, Kudo Y, 第70回日本産科婦人科学会学術講演会, 2018年05月10日, 通常, 英語, 仙台
  12. Progesterone inhibits preterm birth by suppressing the expression of contractile associated proteins and ion channels in mice with chronic dental Porphyromonas gingivalis infection, Konishi H, Urabe S, Teraoka Y, Miyoshi H, Miyauchi M, Takata T, Kudo Y, 第70回日本産科婦人科学会学術講演会, 2018年05月10日, 通常, 英語
  13. Anti-inflammatory effect of progesterone suppresses the enhancement of inflammatory cytokines in fetal membrane in a preterm birth mouse model with chronic dental infection, Teraoka Y, Urabe S, Konishi H, Miyoshi H, Miyauchi M, Takata T, Kudo Y, 第70回日本産科婦人科学会学術講演会, 2018年05月10日, 通常, 英語
  14. Development of peptide drug against bone destruction, Yamada S, Chanbora C, Miyauchi M, Tanimto K, Takata T, 第51回広島大学歯学会総会, 2018年06月11日, 通常, 英語
  15. Porphyromonas gingivalis-odontogenic infection promotes development/progression of nonalcoholic steatohepatitis-related hepatocellular carcinoma, Sakamoto S, Furusho H, Shrestha M, Miyauchi M, Takata T, 第51回広島大学歯学会総会, 2018年06月11日, 通常, 英語, 広島
  16. Porphyromonas gingivalis歯性感染はintegrinシグナル経路を介しNASH関連肝癌の発生および進行を促進する, 坂本真一,Shrestha M,古庄寿子,宮内睦美,髙田 隆, 第29回日本臨床口腔病理学会総会/第11回日本検査学会総会共済学術大会, 2018年08月25日, 通常, 日本語, 東京
  17. Odontogenic tumors revisited: Analysis over a period of 40 years in Hiroshima University based on WHO-2017 classification; probing into the “cyst versus tumor controversies” from WHO-2005 until -2017, Shrestha M, Ogawa I, Miyauchi M, Takata T, :第29回日本臨床口腔病理学会総会/第11回日本検査学会総会共済学術大会, 2018年08月25日, 通常, 日本語, 東京
  18. Porphyromonas gingivalis の歯性感染は非アルコール性脂肪性肝炎の病態を増悪する, 宮内睦美, 古庄寿子,坂本真一,高田 隆, 第60回歯科基礎医学会学術大会, 2018年09月05日, 招待, 日本語, 福岡
  19. ラクトフェリン研究に基づく骨破壊性病変に対する新規ペプチド薬の開発, 山田 桜,Chea C,宮内睦美,谷本幸太郎,高田 隆, 日本ラクトフェリン学会第8回学術集会, 2018年10月27日, 通常, 日本語, 広島
  20. The effects of oral administration of liposomal bovine lactoferrin on secretory IgA production, Chea C, Yamada S, Miyauchi M, Uesaki S, Suido H, Imanaka H, Takata T, 日本ラクトフェリン学会第8回学術集会, 2018年10月27日, 通常, 日本語, 広島