栗原 英見Hidemi Kurihara

Last Updated :2019/11/01

所属・職名
大学院医系科学研究科(歯)(歯学)歯周病態学教授
メールアドレス
hkurihiroshima-u.ac.jp
その他連絡先
広島市南区霞一丁目2番3号

基本情報

主な職歴

  • 1983年01月01日, 1984年03月31日, 岡山大学, 助手
  • 1984年01月01日, 1992年03月31日, 岡山大学, 講師
  • 1989年11月21日, Emory University, GA,USA, Dental Research Center, Visiting Researcher
  • 1991年01月01日, Eastman Dental Center, Visiting Researcher
  • 1992年04月01日, 1995年08月31日, 岡山大学, 助教授
  • 1995年09月01日, 広島大学, 歯学部, 教授
  • 2002年04月01日, 2019年03月31日, 広島大学大学院医歯薬学総合研究科, 歯周病態学研究室, 教授
  • 2002年04月01日, 2004年03月31日, 広島大学歯学部附属病院, 病院長
  • 2004年04月01日, 2008年03月31日, 広島大学, 歯学部, 歯学部長
  • 2008年04月01日, 2009年03月31日, 広島大学, 副理事
  • 2009年08月01日, 台北医学大学, 客員教授
  • 2011年04月01日, 広島大学病院, 主席副病院長
  • 2012年, 2019年03月31日, 広島大学大学院医歯薬保健学研究院, 応用生命科学部門 歯周病態学研究室, 教授

学歴

  • 広島大学, 歯学部, 歯学科, 日本, 1974年04月, 1980年03月

学位

  • 博士(歯学)(岡山大学)

研究分野

  • 医歯薬学 / 歯学 / 歯周治療系歯学

研究キーワード

  • 歯周病
  • 自己抗体
  • 遺伝子診断
  • 侵襲性歯周炎
  • 歯周病予防
  • 歯周組織再生
  • 間葉系幹細胞
  • 脳由来神経栄養因子
  • 薬物性歯肉増殖症
  • 関節リウマチ

所属学会

  • 日本歯周病学会, 1978年04月
  • 日本歯科保存学会, 1980年04月
  • 日本口腔検査学会, 2007年11月
  • 歯科基礎医学会, 1984年05月
  • 日本歯科医学教育学会, 2005年08月
  • 日本免疫学会, 1994年01月
  • 日本細菌学会, 1988年04月
  • 日本再生医療学会, 2004年03月
  • 日本人類遺伝学会, 1996年10月
  • 日本組織培養学会, 1996年10月
  • 日本老年医学会, 2013年02月
  • 日本リウマチ学会, 2013年11月
  • 日本環境感染学会, 2013年09月

教育活動

授業担当

  1. 2019年, 学部専門, 2ターム, 歯周病学
  2. 2019年, 学部専門, 1ターム, 歯学研究特論I
  3. 2019年, 学部専門, 4ターム, 歯学概論
  4. 2019年, 学部専門, 3ターム, 歯周病学
  5. 2019年, 学部専門, 年度, 応用口腔医学特論
  6. 2019年, 学部専門, 1ターム, 歯周療法学基礎実習I
  7. 2019年, 学部専門, 2ターム, 歯周療法学基礎実習II
  8. 2019年, 学部専門, 3ターム, 診断・検査学
  9. 2019年, 学部専門, 4ターム, 歯周病態学演習・実習
  10. 2019年, 学部専門, 1ターム, 国際歯科医学特論
  11. 2019年, 学部専門, 1ターム, 歯科医療安全学
  12. 2019年, 学部専門, セメスター(前期), 成人・高齢者歯科学
  13. 2019年, 学部専門, 2ターム, 臨床歯科医学総合演習
  14. 2019年, 学部専門, 年度, 臨床実習(予防歯科学)
  15. 2019年, 学部専門, 年度, 臨床実習(歯周療法学)
  16. 2019年, 学部専門, 年度, 臨床実習(口腔検査学)
  17. 2019年, 学部専門, セメスター(前期), 成人・高齢者歯科学
  18. 2019年, 学部専門, 1ターム, 歯科医療管理学示説B
  19. 2019年, 学部専門, セメスター(前期), 口腔工学概論
  20. 2019年, 学部専門, セメスター(前期), 成人・高齢者歯科学
  21. 2019年, 学部専門, 1ターム, 歯科医療管理学示説B
  22. 2019年, 修士課程・博士課程前期, セメスター(後期), 予防医学・健康指導特論Ⅱ
  23. 2019年, 修士課程・博士課程前期, セメスター(後期), 予防医学・健康指導特論Ⅱ
  24. 2019年, 修士課程・博士課程前期, セメスター(前期), 口腔健康科学特論
  25. 2019年, 博士課程・博士課程後期, セメスター(前期), 歯周病態学特別演習
  26. 2019年, 博士課程・博士課程後期, セメスター(後期), 歯周病態学特別演習
  27. 2019年, 博士課程・博士課程後期, セメスター(前期), 歯周病態学特別実験
  28. 2019年, 博士課程・博士課程後期, セメスター(後期), 歯周病態学特別実験
  29. 2019年, 修士課程・博士課程前期, 3ターム, 予防医学・健康指導特論B
  30. 2019年, 修士課程・博士課程前期, セメスター(前期), 口腔健康科学特論

研究活動

学術論文(★は代表的な論文)

  1. The expressions of claudin-1 and E-cadherin in junctional epithelium, JOURNAL OF PERIODONTAL RESEARCH, 45巻, 4号, pp. 579-582, 201008
  2. FGF-2 Stimulates Periodontal Regeneration: Results of a Multi-center Randomized Clinical Trial, JOURNAL OF DENTAL RESEARCH, 90巻, 1号, pp. 35-40, 201101
  3. Proteome analysis of proteins related to aggressive periodontitis combined with neutrophil chemotaxis dysfunction, JOURNAL OF CLINICAL PERIODONTOLOGY, 38巻, 4号, pp. 310-317, 201104
  4. Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration, TISSUE ENGINEERING PART A, 17巻, 7-8号, pp. 955-967, 201104
  5. Polarization-dependent Ti K X-ray absorption and emission studies of Ti2O3 single crystal, JOURNAL OF ELECTRON SPECTROSCOPY AND RELATED PHENOMENA, 184巻, 3-6号, pp. 184-187, 201104
  6. Humoral immune response to an antigen from ┣DBPorphyromonas gingivalis(/)-┫DB 381 in periodontal disease, Infection and Immunity, 59巻, pp. 8, 19910401
  7. Monoclonal antibody to a specific antigen from ┣DBWolinella recta(/)-┫DB ATCC 33238, FEMS Microbiological letters, pp. 82, 19910401
  8. Molecular cloning and sequence analysis of antigen gene ┣DBtdp(/)-┫DBA of ┣DBTreponema denticle(/)-┫DB, Infection and Immunity, 59巻, pp. 6, 19910401
  9. Isolation and partial characterization of a 39-kDa major outer membrane protein of ┣DBActiobacillus(/)-┫DB ┣DBactinomycetemcomitans(/)-┫DB Y4, FEMS Microbiological letters, pp. 77, 19910401
  10. Purification and characterization of two major outer membrane proteins from ┣DBPorphyromonas(/)-┫DB ┣DBgingivalis(/)-┫DB, Dentistry in Japan, pp. 27, 19900401
  11. A family study of a mother and daughter with increased susceptibility to early-onset periodontitis : Microbiological immunological host defensive, and genetic analysis, Journal of Periodontology, 61巻, pp. 12, 19900401
  12. Serum immunogloblin G antibody to periodontal bacteria, Advanced Dental Research, 2巻, pp. 2, 19880401
  13. Calcium-dependent protein kinase C activity of neutrophils in localized juvenile periodontitis, Infection and Immunity, 61巻, 8号, pp. 3137-3142, 19930401
  14. Abnormal proportion of r┣D1δ┫D1 T cell in peripheral blood is frequently detected in patients with periodontal disease, J. Periodontol, 64号, pp. 963-967, 19930401
  15. Effect of Ca┣D12+┫D1 on the binding of ┣DBActinobacillus actinomycetemcomitans(/)-┫DB leukotoxin and the cytotoxicity to promyelocytic leukemia HL-60 cells, Biochemistry and Molecular Biology International, 29巻, 5号, pp. 899-905, 19930401
  16. Antigenic properties of ┣DBCompylobactor rectus(/)-┫DB┣DB(Wolinella recta)(/)-┫DBmajor S-layer proteins, FEMS Microbiology Letters, 108号, pp. 275-280, 19930401
  17. Molecular cloning of the S-layer protein gene of ┣DBCompylobactor rectus(/)-┫DBATCC 33238, FEMS Microbiology Letters, 116号, pp. 13-18, 19940401
  18. Role of cytokine in the induction of adhesion molecules on cultured human gingival fibroblast, J. Periodontol, 65号, pp. 230-235, 19940401
  19. The inhibition of interferon-γ-induced upregulation of HLA-DR expression on cultured human gingival fibroblasts by interleukin-1 β or tumor necrosis factor-α, J. Periodontol, 65巻, pp. 336-341, 19940401
  20. Unique intronic variations of HLA-DQ β gene in early-onset periodontitis., J. Periodontol, 65巻, pp. 379-386, 19940401
  21. Heat shock protein 60 (Gro EL) from ┣DBPorphyromonas gingivalis(/)-┫DB : Molecular cloning and sequence analysis of its gene and purification of the recombinant protein., FEMS Microbiology Lett=, 119巻, pp. 129-136, 19940401
  22. Risk factors of periodontal disease involving host defense mechanisms-A case report of acute necrotizing ulcerative periodontitis-, New Zealand Soc Periodontol=, 77巻, pp. 28-33, 19940401
  23. An atypical site in HLA-DQB1 detected in leprosy patients., Int J Lepr=, 62巻, pp. 293-294, 19940401
  24. Biochemical properties of the major outer membrane proteins of ┣DBPorphyromonas gingivalis(/)-┫DB., Microbios, 77巻, pp. 247-252, 19940401
  25. Stimulatory effect of ┣DBActinobacillus actinomycetemcomitans(/)-┫DB leukotoxin on the protein phosphorylation in the HL-60 promyelocytic leukemia cells., Jpn. J. Med. Sci. Biol., 47巻, pp. 312-313, 19940401
  26. Prostaglandin E┣D22┫D2 inhibits interleukin-6 release but not its transcription in human gingival fibroblasts stimulated with interleukin-1β or tumor necrosis factor-α., J. Periodontol, 65巻, pp. 1122-1127, 19940401
  27. Acute necrotizing gingivitis-Risk factors involving host defense mechanisms-, Periodontology 2000, 6巻, pp. 116-124, 19940401
  28. Isolation and characterization of a 53 kDa majour cell envelope protein antigen from Treponema denticola ATCC 35405, J. Periodontal. Res., 29巻, 1号, pp. 70-78, 19940401
  29. Assessment of interleukin-6 in the pathogenesis of periodontal disease, J. Periodontol, 65巻, 2号, pp. 147-153, 19940401
  30. A microbiological and immunological study of endodontic-periodontic lesions., J. Endodontics, 21巻, 12号, pp. 617-621, 19950401
  31. The response of human gingival fibroblasts to prostaglandins, J. Periodontal. Res., 30巻, 5号, pp. 303-311, 19950401
  32. Studis of the phenotypic and functional characterization of peripheral blood lymphocytes from patients with early-onset periodontitis, J. Periodontol, 66巻, 5号, pp. 391-396, 19950401
  33. Clinical and laboratory studies on a patient with rapidly progressive periodontitis and their family members. A case report, J. Periodontol, 66巻, 5号, pp. 403-412, 19950401
  34. Distribution of black-pigmented Prevotella and Porphyromonas species in the dentition of moderate periodontitis patients, Microbial Ecology in Health and Disease, 8巻, pp. 159-169, 19950401
  35. Immunological, genetic, and microbiological study of family members manifesting eraly-onset periodontitis, J. Periodontol, 67巻, 3号, pp. 254-263, 19960401
  36. Host defensive functions in a family manifesting early-onset periodontitis patients, Microbial Ecology in Health and Disease, 67巻, 4号, pp. 433-422, 19960401
  37. ある急速進行性歯周炎患者の臨床的、細菌学的ならびに免疫学的病態研究, 日歯保誌, 38巻, 1号, pp. 180-188, 19950401
  38. Immunological, genetic, and microbiological study of family members manifesting early-onset periodontitis., J. Periodontol, 67巻, pp. 254-263, 19960401
  39. Host defensive functions in a family manifesting early-onset periodontitis., J. Periodontol, 67巻, pp. 433-442, 19960401
  40. New attachment to periodontlly deseased root surfaces treated with hydrochloric acid., Oral Medicine and Pathology, 1巻, pp. 23-28, 19960401
  41. Ultrastrucural and immunocytochemical characterization of the bone-single crystal sapphire implant interface in the rat of maxilla., Medicine and Pathology, 1巻, pp. 84-87, 19960401
  42. HLA class II genotypes associated with early-onset periodontitis : DQB1 molecule, J. Periodontol, 67巻, pp. 888-894, 19960401
  43. Glucose-mediated alteration of cellular function in human periodontal ligament cells., Journal of Dental Research, 75巻, 9号, pp. 1664-1671, 19960401
  44. Assessment of in vitro interleukin-2-producing capacity of peripheral blood lymphocytes from patients with periodontitis., J. Clin. Periodontol., 24巻, 1号, pp. 44-50, 19970401
  45. Molecular cloning and characterization of the gene encoding 53 kDa outer membrane protein of Porphyromonas gingivalis., Microbios, 92巻, pp. 47-57, 19970401
  46. The regulatory effect of fermentable sugar levels on the production of leukotoxin by Actinobacillus actinomycetemcomitans, FEMS Microbiology Letters, 146巻, pp. 161-166, 19970401
  47. 歯周疾患患者の歯槽骨欠損部に填塞したリン酸カルシウムセメントの臨床評価, 日本歯科保存学会誌, 40巻, 4号, pp. 975-984, 19970401
  48. Characterization of Bacteroides forsyhus isolates., Clin Microbiol, 35巻, 6号, pp. 1378-1381, 19970401
  49. Host defensive, immunological, and microbiological observations of an early-onset periodontitis patient with virus-associated hemophagocytic syndrome, J. Periodontol, 68巻, 12号, pp. 1223-1230, 19970401
  50. Immunocytochemical and immunochemical study of emamelins, using anibodies against porcine 89-kDa enamelin and its N-terminal synthetic peptide, in porcine tooth germs., Cell Tissue Res., 293巻, pp. 313-325, 19980401
  51. T cell responses to 53-kDa outer membrane protein of Porphyromonas gingivalis in humans with early-onset periodontitis., Human Immunology, 59巻, pp. 635-643, 19980401
  52. The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans is a cytolethal distending toxin, Infect Immune, 66巻, pp. 5008-5019, 19980401
  53. Effect of glycyrrhetinic acid on the viability of human gingival fibroblasts., J. Korean Academy of Periodontology, 28巻, pp. 453-463, 19980401
  54. 細菌16SリボゾームRNA遺伝子に基づくDNAプローブを用いた歯周病細菌の同定-コロニーハイブリダイゼーション法-, 日本歯周病学会誌, 40巻, pp. 475-485, 19980401
  55. 歯周組織再生過程における硬組織界面の微細構造および細胞化学的検索, 医・生電顕会誌, 12巻, pp. 11-13, 19970401
  56. 歯周病と薬剤, 広島県病院薬剤師会誌, 33巻, pp. 4-14, 19980401
  57. 歯周組織再生療法 GTR法を中心に, 広島歯科医学雑誌, 26巻, pp. 1-14, 19980401
  58. T cell responses to 53-kDa outer membrane protein of ┣DBPorphyromonas gingivalis(/)-┫DB in humans with early-onset periodontitis, Human Immunology, 59巻, pp. 635-643, 19980401
  59. Comparative study of two outer membrane protein genes from ┣DBPorphyromonas gingivalis(/)-┫DB, Microbios, 95巻, pp. 91-100, 19980401
  60. Expression of osteoprotegrin(osteoclastogenesis inhibitory factor)in cultures of human dental mesenchymal cells and epithelial cells, Journal of Bone and Mineral Research, 14巻, pp. 1486-1492, 19990401
  61. Platelet-activating factor in gingival crevicular fluid from periodontitis patients as a potential clinical disease activity marker, Journal of the International Academy of Periodontology, 1巻, pp. 60-64, 19990401
  62. Adherence of ┣DBBacteroides forsythus(/)-┫DB to host cells, Microbios, 101巻, pp. 115-126, 20000401
  63. Effects of ageing on proliferative ability, and the expression of secreted protein, acidic and rich in cysteine(SPARC)and osteoprotegerin(osteoclastogenesis inhibitory factor)in cultures of human periodontal ligament cells, Mech. Ageing Dev., 117巻, pp. 69-77, 20000401
  64. Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils, Prostaglandins & other Lipid Mediators, 62巻, pp. 385-394, 20000401
  65. 十代に発症し急速に進行する歯周炎-早期発症型歯周炎の病態-, 広島大学保健管理センター研究論文集, 17巻, pp. 83-90, 20010401
  66. Identification and characterization of B-cell epitopes of 53-kDa outer membrane protein from ┣DBPorphyromonas gingivalis(/)-┫DB, Oral Microbiol Immunol, 16巻, pp. 73-78, 20010401
  67. Clinical periodontal findings and microflora profiles in children with chronic neutropenia under supervised oral hygiene, J. Periodontol, 72巻, pp. 945-952, 20010401
  68. Molecular cloning and characterization of rat trp homologues from brain, Molecular Brain Research, 64巻, 1号, pp. 41-51, 19990101
  69. Mediation by platelate-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in rabbit and human neutrophils, Prostaglandins & other Lipid Mediators, 62巻, pp. 385-394, 20000401
  70. New attachment to periodontally diseasedroot surfaces treated with hydrochloric acid, Oral Medicine Pathology, pp. 23-28, 19960401
  71. Clinical evaluation of a dental rinse containing aluminum lactate for treatment of dental hypersensitivity, Journal of Clinical Dentistry, pp. 912, 19960401
  72. Host defensive functions in a family manifesting early-onset periodontitis, Journal of Periodontology, pp. 433-442, 19960401
  73. Immunological, genetic, and microbiological study of family members manifesting early-onsetperiodontitis, Journal of Periodontology, pp. 254-263, 19960301
  74. Glucose-mediated alteration of cellular function in human periodontal ligament cells, Journal of Dental Research, pp. 1664-1671, 19960901
  75. HLA class Ⅱgenotypes with early-onset periodontitis : DQB1 molecule primarily confers the susceptibility to the disease, Journal of Periodontology, pp. 888-894, 19960901
  76. Characterization of Bacteroides forsythus isolates, Journal of Clinical Microbiology, pp. 1378-1381, 19970601
  77. Assessment of in vitro interleukin-2-producing capacity of peripheral blood lymphocytes from patients with periodontitis, Journal of Clinical Periodontology, pp. 44-50, 19970101
  78. The reguratory effect of fermentable sugar levels on the production of leukotoxin by Actinobacillus actinomycetemcomitans, FEMS Microbiology Letters, pp. 161-166, 19970101
  79. Molecular cloning and characterization of the gene encoding 53 kDa outer membrane protein of Porphyromonas gingivalis, Microbios, pp. 47-57, 19970401
  80. Host defensive, immunological, and microbiological observation of an early-onset periodontitis patient with virus-associated hemophagocytic syndrome, Journal of Periodontology, pp. 1223-1230, 19971201
  81. Differential effects of various growth factors and cytokines on the synthesis of DNA, type I collagen, laminin, fibronectin, osteonectin/SPARC and alkaline phosphatase by human pulp cells in culture., Journal of Cellular Physiology, pp. 194-205, 19980201
  82. Immunocytochemical and immunochemical study of emamelins, using anibodies against porcine 89-kDa enamelin and its N-terminal synthetic peptide, in porcine tooth germs, CELL Tissue Research, pp. 313-325, 19980801
  83. T cell responses to 53-kDa outer membrance protein of Porphyromonas gingivalis in humans with early-onset periodontitis, Human Immunology, pp. 635-643, 19980101
  84. The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans, Infect. Immun., pp. 91-100, 19980101
  85. Comparative study of two outer membrane protein genes from Porphyromonas gingivalis, Microbios, pp. 91-100, 19980401
  86. Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in rabbit and human neutrophils, Prostaglandins & other Lipid Med., 62巻, 4号, pp. 385-394, 20001001
  87. Platelet-activating factor in gingival crevicular fluid from periodontitis patients as a potential clinical disease activity marker, Journal of the International Academy of Periodontology, 1巻, pp. 60-64, 19990401
  88. Molecular cloning and characterization of rat trp homologues from brain, Mol. Brain Res., 64巻, 1号, pp. 41-51, 19990101
  89. Mycolic acid composition of Bacterionema matruchotii grown in shaking culture., J. Osaka Univ. Dent Sch., pp. 115-121, 19820401
  90. Fatty acid composition in phenol extracts from Actinomyces species., J. Dent. Res., pp. 1282-1286, 19821101
  91. Amphipathic antigen from Actinomyces viscosus., FEMS Microbiol. Lett., pp. 267-269, 19840401
  92. Serum immunoglobulin G antibody to periodontal bacteria, Adv Dent Res, pp. 339-345, 19881101
  93. Cell surface protein antigen from Wolinella recta ATCC33238T., J. Clin. Microbiol., pp. 1210-1217, 19890601
  94. Purification and characterization of two major outer membrane proteins from Porphyromonas gingivalis., Dentistry in Japan, pp. 29-34, 19900401
  95. A family study of mother amd daughter with increased susceptibility to early-onset periodontitis: microbiological, immunological, host defensive and genetic analyses., J. Periodontol, pp. 755-765, 19901201
  96. Isolation and partial characterization of a 39 kDa major outer membrane protein of Actinobacillus actinomycetemcomitans Y4., FEMS Microbiol. Lett., pp. 85-90, 19910101
  97. Monoclonal antibody to a specific antigen from Wolinella recta ATCC33238., FEMS Microbiol. Lett., pp. 33-36, 19910701
  98. Molecular cloning and sequence analysis of an antigen gene tdpA of Treponema denticola., Infect. Immun., pp. 1941-1947, 19910601
  99. Humoral immune response to an antigen from Porphyromonas gingivalis 381 in periodontal disease., Infect. Immun., pp. 2758-2762, 19910801
  100. Interleukin-8 is a major neutrophil chemotactic factor derived from cultured human gingival fibroblasts stimulated with interleukin-1βor tumor necrosis factor alpha., Infect. Immun., pp. 5253-5258, 19921201
  101. Effect of Ca2+ on the binding of Actinobacillus actinomycetemcomitans leukotoxin and the cytotoxicity to promyelocytic leukemia HL-60 cells., Biochen Mol Biol Int, pp. 899-905, 19930401
  102. Antigenic properties of Campylobacter rectus(Wolinella recta) major S-layer proteins., FEMS Microbiol. Lett., pp. 275-280, 19930401
  103. Calcium-dependent protein kinase C activity of neutrophils in localized juvenile periodontitis., Infect. Immun., pp. 3137-3142, 19930801
  104. Abnormal proportion of gd Tcells in peripheral blood is frequently detected in patients with periodontal disease., J. Periodontol, pp. 963-967, 19930101
  105. Association of Actinobacillus actinomycetemcomitans leukotoxin with nucleic acids on the bacteria cell surface., Infect. Immun., pp. 4878-4884, 19931101
  106. Molecular cloning of the S-layer protein gene of Campylobacter rectus ATCC33238., FEMS Microbiol. Lett., pp. 13-18, 19940401
  107. Isolation and characterization of a 53 kDa major cell envelope protein antigen from Treponema denticola ATCC35405., J. Periodontal. Res., pp. 70-78, 19940101
  108. Assessment of interleukin-6 in the pathogenesis of periodontal disease., J. Periodontol, pp. 147-153, 19940201
  109. Role of cytokine in the induction of adhesion molecules on cultured human gigival fibroblasts., J. Periodontol, pp. 230-235, 19940301
  110. The inhibition of interferon-g-induced upregulation of HLA-DR expression on cultured human gingival fibroblasts by interleukin-1β or tumor necrosis factor-α, J. Periodontol, pp. 336-341, 19940401
  111. Unique intronic variations of HLA-DQβ gene in early-onset periodontitis., J. Periodontol, pp. 379-386, 19940501
  112. Heat shock protein 60 (Gro EL) from Porphyromonas gingivalis : Molecular cloning and sequence analysis of its gene and purification of the recombinant protein., FEMS Microbiol. Lett., pp. 129-136, 19941101
  113. Risk factors of periodontal disease involving host defense mechanisms-A case report of acute necrotizing uncerative periodontitis-., New Zealand Soc Periodontol=, pp. 28-33, 19940401
  114. An atypical site in HLA-DQBI detected in leprosy patients., Int J Lepr=, pp. 293-294, 19940401
  115. Biochemical properties of the major outer membrane proteins of Porphyromonas gingivalis., Microbios, pp. 247-252, 19940101
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  263. CD38 cleavage in fMLP- and IL-8-induced chemotaxis is dependent on p38 MAP kinase but independent of p44/42 MAP kinase, CELLULAR SIGNALLING, 17巻, 2号, pp. 167-175, 200502
  264. Parotid secretory protein is expressed and inducible in human gingival keratinocytes, JOURNAL OF PERIODONTAL RESEARCH, 40巻, 2号, pp. 153-157, 200504
  265. Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 332巻, 1号, pp. 297-303, 20050624
  266. Brain-derived neurotrophic factor enhances periodontal tissue regeneration, TISSUE ENGINEERING, 11巻, 9-10号, pp. 1618-1629, 200509
  267. CD38 expression in neutrophils from patients with localized aggressive periodontitis, JOURNAL OF PERIODONTOLOGY, 76巻, 11号, pp. 1960-1965, 200511
  268. An in vitro evaluation of the adhesion of Candida species to oral and lung tissue cells, MYCOSES, 49巻, 1号, pp. 14-17, 200601
  269. Salivary enzyme levels after scaling and interleukin-1 genotypes in Japanese patients with chronic periodontitis, JOURNAL OF PERIODONTOLOGY, 78巻, 3号, pp. 498-503, 200703
  270. Effects of overexpression of basic helix-loop-helix transcription factor Dec1 on osteogenic and adipogenic differentiation of mesenchymal stem cells, EUROPEAN JOURNAL OF CELL BIOLOGY, 85巻, 5号, pp. 423-431, 200605
  271. Behavior of transplanted bone marrow-derived mesenchymal stem cells in periodontal defects, JOURNAL OF PERIODONTOLOGY, 77巻, 6号, pp. 1003-1007, 200606
  272. Association of Chlamydia pneumoniae infection and carotid intima-media wall thickness in Japanese Americans, CIRCULATION JOURNAL, 70巻, 7号, pp. 815-819, 200607
  273. Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells, INFECTION AND IMMUNITY, 74巻, 9号, pp. 5211-5220, 200609
  274. Promotion of functioning of human periodontal ligament cells and human endothelial cells by nerve growth factor, JOURNAL OF PERIODONTOLOGY, 77巻, 5号, pp. 800-807, 200605
  275. Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of Actinobacillus actinomycetemcomitans, INFECTION AND IMMUNITY, 74巻, 12号, pp. 7014-7020, 200612
  276. Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells, CELL BIOLOGY INTERNATIONAL, 31巻, 12号, pp. 1462-1469, 200712
  277. Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts, JOURNAL OF PERIODONTAL RESEARCH, 42巻, 3号, pp. 283-286, 200706
  278. Cell adhesion and proliferation patterns on mixed self-assembled monolayers carrying various ratios of hydroxyl and methyl groups, DENTAL MATERIALS JOURNAL, 26巻, 6号, pp. 814-819, 200711
  279. Selection of common markers for bone marrow stromal cells from various bones using real-time RT-PCR: Effects of passage number and donor age, TISSUE ENGINEERING, 13巻, 10号, pp. 2405-2417, 200710
  280. Susceptibility of periodontopathogenic and cariogenic bacteria to Defensins and potential therapeutic use of Defensins in oral diseases, CURRENT PHARMACEUTICAL DESIGN, 13巻, 30号, pp. 3084-3095, 2007
  281. Effect of Neurotrophin-4/5 on Bone/Cementum-Related Protein Expressions and DNA Synthesis in Cultures of Human Periodontal Ligament Cells, JOURNAL OF PERIODONTOLOGY, 79巻, 11号, pp. 2182-2189, 200811
  282. Neodymium-doped Yttrium-Aluminium-Garnet Laser Irradiation Abolishes the Increase in Interleukin-6 Levels Caused by Peptidoglycan through the p38 Mitogen-activated Protein Kinase Pathway in Human Pulp Cells, JOURNAL OF ENDODONTICS, 35巻, 3号, pp. 373-376, 200903
  283. Ceruloplasmin Induces Polymorphonuclear Leukocyte Priming in Localized Aggressive Periodontitis, JOURNAL OF PERIODONTOLOGY, 80巻, 8号, pp. 1300-1306, 200908
  284. Genetic Risk Factors for Periodontitis in a Japanese Population, JOURNAL OF DENTAL RESEARCH, 88巻, 12号, pp. 1137-1141, 200912
  285. Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans, BIOCHEMICAL PHARMACOLOGY, 79巻, 10号, pp. 1496-1505, 20100515
  286. Clinical and Immunological Assessment of Periodontal Disease in Japanese Leprosy Patients, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 63巻, 6号, pp. 427-432, 201011
  287. Irsogladine maleate regulates epithelial barrier function in tumor necrosis factor-alpha-stimulated human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 47巻, 1号, pp. 55-61, 201202
  288. Loss of claudin-1 in lipopolysaccharide-treated periodontal epithelium, JOURNAL OF PERIODONTAL RESEARCH, 47巻, 2号, pp. 222-227, 201204
  289. Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrin alpha(V)beta(3)-FAK cascade, JOURNAL OF CELLULAR PHYSIOLOGY, 227巻, 5号, pp. 2123-2129, 201205
  290. Caries prevalence associated with Streptococcus mutans and Streptococcus sobrinus in Japanese schoolchildren, INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY, 22巻, 5号, pp. 342-348, 201209
  291. Smad2 is involved in the apoptosis of murine gingival junctional epithelium associated with inhibition of Bcl-2, ARCHIVES OF ORAL BIOLOGY, 57巻, 11号, pp. 1567-1573, 201211
  292. Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 48巻, 2号, pp. 228-234, 201304
  293. Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans, INTERNATIONAL IMMUNOPHARMACOLOGY, 15巻, 2号, pp. 340-347, 201302
  294. The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect, PEPTIDES, 46巻, pp. 136-142, 201308
  295. Age-dependent decrease in the chondrogenic potential of human bone marrow mesenchymal stromal cells expanded with fibroblast growth factor-2, CYTOTHERAPY, 15巻, 9号, pp. 1062-1072, 201309
  296. BDNF protects human vascular endothelial cells from TNF alpha-induced apoptosis, BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 91巻, 5号, pp. 341-349, 201310
  297. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice, JOURNAL OF GASTROENTEROLOGY, 48巻, 11号, pp. 1259-1270, 201311
  298. ★, The Effect of Brain-Derived Neurotrophic Factor on Periodontal Furcation Defects, PLOS ONE, 9巻, 1号, 20140114
  299. BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade, INTERNATIONAL IMMUNOPHARMACOLOGY, 19巻, 2号, pp. 245-252, 201404
  300. Detecting gene mutations in Japanese Alzheimer's patients by semiconductor sequencing, NEUROBIOLOGY OF AGING, 35巻, 7号, 201407
  301. miR-584 Expressed in Human Gingival Epithelial Cells Is Induced by Porphyromonas gingivalis Stimulation and Regulates Interleukin-8 Production via Lactoferrin Receptor, JOURNAL OF PERIODONTOLOGY, 85巻, 6号, pp. E198-E204, 201406
  302. Amphotericin B down-regulates Aggregatibacter actinomycetemcomitans-induced production of IL-8 and IL-6 in human gingival epithelial cells, CELLULAR IMMUNOLOGY, 290巻, 2号, pp. 201-208, 201408
  303. Smad2 is Involved in Aggregatibacter actinomycetemcomitans-induced Apoptosis, JOURNAL OF DENTAL RESEARCH, 93巻, 11号, pp. 1148-1154, 201411
  304. Introduction of a Mixture of beta-Tricalcium Phosphate Into a Complex of Bone Marrow Mesenchymal Stem Cells and Type I Collagen Can Augment the Volume of Alveolar Bone Without Impairing Cementum Regeneration, JOURNAL OF PERIODONTOLOGY, 86巻, 3号, pp. 456-464, 201503
  305. ★, Houttuynia cordata suppresses the Aggregatibacter actinomycetemcomitans-induced increase of inflammatory-related genes in cultured human gingival epithelial cells, JOURNAL OF DENTAL SCIENCES, 10巻, 1号, pp. 88-94, 201503
  306. ★, The differential expression of mgl mRNA by Porphyromonas gingivalis affects the production of methyl mercaptan, ORAL DISEASES, 21巻, 5号, pp. 626-633, 201507
  307. ★, Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration, CYTOTHERAPY, 17巻, 7号, pp. 860-873, 201507
  308. ★, Brain-derived neurotrophic factor prevents the endothelial barrier dysfunction induced by interleukin-1 beta and tumor necrosis factor-alpha, JOURNAL OF PERIODONTAL RESEARCH, 50巻, 4号, pp. 444-451, 201508
  309. Interleukin-8 induces DNA synthesis, migration and down-regulation of cleaved caspase-3 in cultured human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 50巻, 4号, pp. 479-485, 201508
  310. ★, Irsogladine maleate inhibits Porphyromonas gingivalis-mediated expression of toll-like receptor 2 and interleukin-8 in human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 50巻, 4号, pp. 486-493, 201508
  311. LL37 induces VEGF expression in dental pulp cells through ERK signalling, INTERNATIONAL ENDODONTIC JOURNAL, 48巻, 7号, pp. 673-679, 201507
  312. Involvement of smad2 and Erk/Akt cascade in TGF-beta 1-induced apoptosis in human gingival epithelial cells, CYTOKINE, 75巻, 1号, pp. 165-173, 201509
  313. ★, Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration, EUROPEAN JOURNAL OF ORAL SCIENCES, 124巻, 2号, pp. 141-150, 201604
  314. Randomized Placebo-Controlled and Controlled Non-Inferiority Phase III Trials Comparing Trafermin, a Recombinant Human Fibroblast Growth Factor 2, and Enamel Matrix Derivative in Periodontal Regeneration in Intrabony Defects, JOURNAL OF BONE AND MINERAL RESEARCH, 31巻, 4号, pp. 806-814, 201604
  315. ★, Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain-Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells, JOURNAL OF CELLULAR BIOCHEMISTRY, 117巻, 7号, pp. 1543-1555, 201607
  316. ★, Brain-Derived Neurotrophic Factor Inhibits Intercellular Adhesion Molecule-1 Expression in Interleukin-1 beta-Treated Endothelial Cells, CELL BIOCHEMISTRY AND BIOPHYSICS, 74巻, 3号, pp. 399-406, 201609
  317. ★, Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-alpha, ARCHIVES OF ORAL BIOLOGY, 62巻, pp. 64-69, 201602
  318. ★, Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 186巻, 2号, pp. 177-189, 201611
  319. Identification of six major outer membrane proteins from Actinobacillus actinomycetemcomitans., Identification of six major outer membrane proteins from Actinobacillus actinomycetemcomitans., 288巻, 1-2号, 2002
  320. Osteoprotegerin levels increased by interleukin-1beta in human periodontal ligament cells are suppressed through prostaglandin E(2) synthesized de novo., Osteoprotegerin levels increased by interleukin-1beta in human periodontal ligament cells are suppressed through prostaglandin E(2) synthesized de novo., 18巻, 3号, 2002
  321. Microbiological, immunological and genetic factors in family members with periodontitis as a manifestation of systemic disease, associated with hematological disorders., Microbiological, immunological and genetic factors in family members with periodontitis as a manifestation of systemic disease, associated with hematological disorders., 37巻, 4号, 2002
  322. SPARC stimulates the synthesis of OPG/OCIF, MMP-2 and DNA in human periodontal ligament cells., SPARC stimulates the synthesis of OPG/OCIF, MMP-2 and DNA in human periodontal ligament cells., 31巻, 6号, 2002
  323. Effects of transforming growth factor-beta 1 and fibronectin on SPARC expression in cultures of human periodontal ligament cells., Effects of transforming growth factor-beta 1 and fibronectin on SPARC expression in cultures of human periodontal ligament cells., 26巻, 12号, 2002
  324. Proliferative ability and alkaline phosphatase activity with in vivo cellular aging in human pulp cells., Proliferative ability and alkaline phosphatase activity with in vivo cellular aging in human pulp cells., 29巻, 1号, 2003
  325. Immunohistochemical characteristics of epithelial cell rests of Malassez during cementum repair., Immunohistochemical characteristics of epithelial cell rests of Malassez during cementum repair., 38巻, 1号, 2003
  326. Neurotrophins in cultured cells from periodontal tissues., Neurotrophins in cultured cells from periodontal tissues., 74巻, 1号, 2003
  327. The effect of extracellular calcium ion on gene expression of bone-related proteins in human pulp cells., The effect of extracellular calcium ion on gene expression of bone-related proteins in human pulp cells., 29巻, 2号, 2003
  328. Prevalence of cytolethal distending toxin production in periodontopathogenic bacteria., Prevalence of cytolethal distending toxin production in periodontopathogenic bacteria., 41巻, 4号, 2003
  329. Expression of endothelins and their receptors in cells from human periodontal tissues., Expression of endothelins and their receptors in cells from human periodontal tissues., 38巻, 3号, 2003
  330. Macrophage inflammatory protein-3alpha and beta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells., Macrophage inflammatory protein-3alpha and beta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells., 306巻, 4号, 2003
  331. Differential gene expression of bone-related proteins in epithelial and fibroblastic cells derived from human periodontal ligament., Differential gene expression of bone-related proteins in epithelial and fibroblastic cells derived from human periodontal ligament., 27巻, 7号, 2003
  332. An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus., An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus., 278巻, 50号, 2003
  333. Enhancement of alkaline phosphatase synthesis in pulp cells co-cultured with epithelial cells derived from lower rabbit incisors., Enhancement of alkaline phosphatase synthesis in pulp cells co-cultured with epithelial cells derived from lower rabbit incisors., 27巻, 10号, 2003
  334. Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans., Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans., 50巻, 4号, 2003
  335. Syntheses of prostaglandin E2 and E-cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans., Syntheses of prostaglandin E2 and E-cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans., 27巻, 6号, 2003
  336. Differential effects of growth factors and cytokines on the synthesis of SPARC, DNA, fibronectin and alkaline phosphatase activity in human periodontal ligament cells., Differential effects of growth factors and cytokines on the synthesis of SPARC, DNA, fibronectin and alkaline phosphatase activity in human periodontal ligament cells., 28巻, 4号, 2004
  337. Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system., Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system., 382巻, Pt 1号, 2004
  338. Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells., Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells., 75巻, 9号, 2004
  339. Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells., Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells., 28巻, 10号, 2004
  340. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins., Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins., 29巻, 2号, 2005
  341. Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells., Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells., 55巻, 6号, 2005
  342. Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts., Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts., 332巻, 1号, 2005
  343. Irsogladine maleate influences the response of gap junctional intercellular communication and IL-8 of human gingival epithelial cells following periodontopathogenic bacterial challenge., Irsogladine maleate influences the response of gap junctional intercellular communication and IL-8 of human gingival epithelial cells following periodontopathogenic bacterial challenge., 333巻, 2号, 2005
  344. [Cell transplantation for periodontal diseases. A novel periodontal tissue regenerative therapy using bone marrow mesenchymal stem cells]., [Cell transplantation for periodontal diseases. A novel periodontal tissue regenerative therapy using bone marrow mesenchymal stem cells]., 15巻, 7号, 2005
  345. Brain-derived neurotrophic factor enhances periodontal tissue regeneration., Brain-derived neurotrophic factor enhances periodontal tissue regeneration., 11巻, 9-10号
  346. Effects of overexpression of basic helix-loop-helix transcription factor Dec1 on osteogenic and adipogenic differentiation of mesenchymal stem cells., Effects of overexpression of basic helix-loop-helix transcription factor Dec1 on osteogenic and adipogenic differentiation of mesenchymal stem cells., 85巻, 5号, 2006
  347. Human autologous serum obtained using a completely closed bag system as a substitute for foetal calf serum in human mesenchymal stem cell cultures., Human autologous serum obtained using a completely closed bag system as a substitute for foetal calf serum in human mesenchymal stem cell cultures., 30巻, 6号, 2006
  348. Promotion of functioning of human periodontal ligament cells and human endothelial cells by nerve growth factor., Promotion of functioning of human periodontal ligament cells and human endothelial cells by nerve growth factor., 77巻, 5号, 2006
  349. Behavior of transplanted bone marrow-derived mesenchymal stem cells in periodontal defects., Behavior of transplanted bone marrow-derived mesenchymal stem cells in periodontal defects., 77巻, 6号, 2006
  350. Association of Chlamydia pneumoniae infection and carotid intima-media wall thickness in Japanese Americans., Association of Chlamydia pneumoniae infection and carotid intima-media wall thickness in Japanese Americans., 70巻, 7号, 2006
  351. Regulation of IL-8 by Irsogladine maleate is involved in abolishment of Actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication., Regulation of IL-8 by Irsogladine maleate is involved in abolishment of Actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication., 34巻, 5-6号, 2006
  352. Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells., Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells., 74巻, 9号, 2006
  353. Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of Actinobacillus actinomycetemcomitans., Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of Actinobacillus actinomycetemcomitans., 74巻, 12号, 2006
  354. Selection of common markers for bone marrow stromal cells from various bones using real-time RT-PCR: effects of passage number and donor age., Selection of common markers for bone marrow stromal cells from various bones using real-time RT-PCR: effects of passage number and donor age., 13巻, 10号, 2007
  355. Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells., Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells., 31巻, 12号, 2007
  356. Cell adhesion and proliferation patterns on mixed self-assembled monolayers carrying various ratios of hydroxyl and methyl groups., Cell adhesion and proliferation patterns on mixed self-assembled monolayers carrying various ratios of hydroxyl and methyl groups., 26巻, 6号, 2007
  357. Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts., Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts., 283巻, 23号, 2008
  358. [Clinical trial of periodontal tissue regeneration]., [Clinical trial of periodontal tissue regeneration]., 66巻, 5号, 2008
  359. Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells., Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells., 79巻, 12号, 2008
  360. RUNX3 has an oncogenic role in head and neck cancer., RUNX3 has an oncogenic role in head and neck cancer., 4巻, 6号, 2009
  361. Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death., Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death., 221巻, 3号, 2009
  362. The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics., The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics., 36巻, 6号, 2010
  363. Characteristics of high-molecular-weight hyaluronic acid as a brain-derived neurotrophic factor scaffold in periodontal tissue regeneration., Characteristics of high-molecular-weight hyaluronic acid as a brain-derived neurotrophic factor scaffold in periodontal tissue regeneration., 17巻, 7-8号, 2011
  364. Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis., Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis., 4巻, 2012
  365. Brain-Derived Neurotrophic Factor Inhibits Peptidoglycan-Induced Inflammatory Cytokine Expression in Human Dental Pulp Cells, INFLAMMATION, 40巻, 1号, pp. 240-247, 201702
  366. Xenotransplantation of interferon-gamma-pretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration, STEM CELL RESEARCH & THERAPY, 8巻, 20170426
  367. A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation, JOURNAL OF IMMUNOLOGICAL METHODS, 445巻, pp. 31-36, 201706
  368. MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration, JOURNAL OF DENTAL RESEARCH, 96巻, 9号, pp. 984-991, 201708
  369. Prevalence of Torus Mandibularis in Young Healthy Dentate Adults, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 75巻, 12号, pp. 2593-2598, 201712
  370. Effect of local bone marrow stromal cell administration on ligature-induced periodontitis in mice, JOURNAL OF ORAL SCIENCE, 59巻, 4号, pp. 629-637, 201712

著書等出版物

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  2. 1994年, Molecular Pathogenesis of periodontal Disease , American Society for Microbiology, 1994年, 栗原 英見
  3. 1996年, 歯周病学 , 永末書店, 1996年, 栗原 英見
  4. 1999年, 歯周病診断のストラテジー(共著) , 医歯薬出版株式会社, 1999年, 栗原 英見
  5. 1999年, 知っておきたい歯内療法術式編 , 第一歯科出版, 1999年, 栗原 英見
  6. 2000年, 歯周病学最前線 , 日本歯科評論, 2000年, 栗原 英見
  7. 2000年, 先端医療シリーズ・歯科医学2歯周病, 新しい治療を求めて , 先端医療研究所, 2000年, 栗原 英見
  8. 1994年, Leukocyte adhesion molecules CD11/CD18 and their role in periodontal diseases; In Molecular Pathogenesis of Periodontal Disease , American Society for Microbiology, 1994年, 共著, 栗原 英見
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  10. 1996年, 歯周治療における修復・補綴的配慮 : 歯周病学 , 永末書店, 1996年, 単行本(学術書), 共編著, 栗原 英見
  11. 1999年, 高齢者の診断・治療を考える-21世紀の課題-;歯周病診断のストラテジー , 医歯薬出版株式会社, 1999年, 単行本(学術書), 共編著, 栗原 英見
  12. 1999年, 感染根管治療法 ; 知っておきたい歯内療法術式編 , 第一歯科出版, 1999年, 単行本(学術書), 共編著, 栗原 英見
  13. 2000年, 歯根膜細胞の老化(歯周病学最前線) , 日本歯科評論, 2000年, 単行本(学術書), 共編著, 栗原 英見
  14. 2000年, 社会的・心理的ストレス刺激と歯周病 , 先端医療研究所, 2000年, 単行本(学術書), 共編著, 栗原 英見
  15. 2001年, 十代に発症し急速に進行する歯周炎ー早期発症型歯周炎の病態ー , 総合保健科学, 2001年, 単行本(一般書), 共編著, 栗原 英見
  16. 2001年, 糖尿病と歯周病の関係 , 総合保健科学, 2001年, 単行本(一般書), 共編著, 栗原 英見
  17. 2001年, ペリオドンタルメディスン , 医歯薬出版株式会社, 2001年, 単行本(学術書), 共訳, 栗原 英見
  18. 2001年06月, プログレッシブテクニック臨床医のための歯周治療 , 永末書店, 2001年, 06, 単行本(学術書), 共編著, 栗原 英見
  19. 2002年02月, アクチノバチルス属 細胞膨化致死毒素.  細菌毒素ハンドブック(櫻井, 本田, 小熊編)Science Forum p.23- 29. 2002. , Science Forum・細菌毒素ハンドブック, 2002年, 02, 単行本(学術書), 共編著, 小原 勝 川本 亨 上野葉子 栗原 英見 菅井基行. , 7
  20. 2004年09月, 骨髄間葉系幹細胞移植による歯周組織再生治療 , ザ・クインテッセンス, 2004年, 09, 単行本(学術書), 共著, 林 秀昭 栗原 英見 , 5
  21. 2003年11月, 歯科用Nd:YAGレーザーの臨床応用 歯内療法への使用に際しての考え方とその背景 , クインテッセンス, 2003年, 11, 単行本(学術書), 共編著, 栗原 英見 吉野 宏
  22. 2006年05月, 骨髄間葉系幹細胞移植による歯周組織再生 , 2006年, 05, 単行本(学術書), 共編著, 栗原 英見
  23. 2007年03月, 臨床歯周病学:ティッシュエンジニアリングの応用 , 2007年, 03, 教科書, 共編著, 栗原 英見
  24. 2006年04月, 骨髄間葉系幹細胞移植による歯周組織再生過程に関する研究 -ラット歯周組織欠損モデルを用いた細胞分化過程に関する組織学的検討- , 第49回 日本歯周病学会春季学術大会(市川), 2006年, 04, 調査報告書, 共著, 花木 清隆 林田 浩一 長谷川 直彦 尾関 良賢 北本 泰子 加治屋 幹人 河口 浩之 辻 紘一郎 栗原 英見
  25. 2006年04月, 糖尿病を合併した歯周炎でのグルココルチコイドの発現ならびにインスリンの影響 , 第49回 日本歯周病学会秋季学術大会(大阪),2006, 2006年, 04, 調査報告書, 共著, 赤崎 友彦 中村 茂夫 栗原 英見 吉野 宏 林田 浩一 工藤 靖爾 花木 清隆 常國 徳子 永原 隆吉 柴 秀樹 河口 浩之
  26. 2006年04月, 脳由来神経栄養因子を用いた歯周組織再生過程における骨関連タンパク発現 , 第125回 日本歯科保存学会秋季学術大会(鹿児島), 2006年, 04, 調査報告書, 共著, 林田 浩一 河口 浩之 花木 清隆 水野 智仁 赤崎 友彦 武田 克浩 岡田 貢 辻 紘一郎 栗原 英見
  27. 2007年08月, 歯科医療における院内感染予防対策マニュアル&研修テキスト, 医歯薬出版, 2007年, 08, 編著, 9784263442432, 159
  28. 2002年01月, 歯科医療における感染予防対策と滅菌・消毒・洗浄, 医歯薬出版, 2002年, 01, 編著, 9784263441459, 132

招待講演、口頭・ポスター発表等

  1. 歯周治療最前線, 栗原 英見, 日本歯科保存学会2015年度秋季学術大会, 2015年11月13日, 招待, 日本語, 日本歯科保存学会, 東京
  2. 高齢者の歯周病治療の多面的考察, 栗原 英見, 平成27年度第58回秋季日本歯周病学会学術大会, 2015年09月13日, 招待, 日本語, 日本歯周病学会, 浜松市
  3. Reconsideration of Periodontal Medicine Research: Interface between Epidemiological Findings and Pathogenic Mechanisms, 栗原 英見, 2014年12月04日, 招待, 日本語, 国際歯科医学研究学会日本部会, 大阪市
  4. Update on Cytokine and Cell Therapy for Periodontal Tissue Regeneration, Hidemi Kurihara, Taiwan Academy of Periodontology (TAP) Annual Meeting of 2014, 2014年11月09日, 招待, 英語, Tawan Academy of Periodontology, Kaohsiung, Taiwan(高雄、台湾)
  5. 医歯連携における歯科医療・歯周病治療のあり方, 栗原 英見, 第57回秋季日本歯周病学会学術大会, 2014年10月19日, 招待, 日本語, 日本歯周病学会, 神戸市
  6. Evidence-Based Dentistryの確立に向けて歯科理工学に期待すること, 栗原 英見, 第64回日本歯科理工学会学術講演会, 2014年10月04日, 招待, 日本語, 日本歯科理工学会, 広島市
  7. 歯科診療室における感染対策の実際, 栗原 英見, 高知口腔科学研究会, 2014年09月28日, 招待, 日本語, 高知大学附属病院口腔外科同門会, 20140928
  8. Cell Therapy for Periodontal Tissue Regeneration, 栗原 英見, AAP 100th Annual Meeting, 2014年09月27日, 招待, 英語, American Academy of Periodontology, San Francisco, USA
  9. 歯周治療の現状と将来展望, 栗原 英見, 平成26年度山口県歯科医師会学術講演会, 2014年09月07日, 招待, 日本語, 山口県歯科医師会, 山口市
  10. 歯科診療所における医療安全管理体制について, 栗原 英見, 感染症予防歯科衛生士講習会, 2014年08月24日, 招待, 日本語, 日本歯科衛生士会, 広島市
  11. 歯周病治療最前線, 栗原 英見, ヒロシマ薬剤師研修会, 2014年07月, 招待, 日本語, 広島県薬剤師会, 広島市
  12. 歯科領域の疫学と対策の実践~国公立大学附属病院感染対策協議会歯科医療部会の取り組みを中心に~, 栗原 英見, 第29回日本環境感染学会総会・学術大会, 2014年02月15日, 招待, 日本語, 日本環境感染学会, 東京
  13. Oral Health Condition is deeply related to Every Stage of Women’s Life Mother’s Oral Health Controls their Children’s Life, 栗原 英見, The 7th National Scientific Meeting in Pediatric Dentistry, 2014年02月09日, 招待, 英語, Indonesia Society of Pediatric Dentistry, Surabaya, Indonesia
  14. Cell based Therapy for Periodontal Tissue Regeneration, 栗原 英見, 2012年10月01日, 招待, 英語, American Academy of Periodontology, Los Angeles
  15. 歯周病組織再生におけるマラッセ上皮細胞の潜在的な役割について, 栗原 英見, The International Academy of Periodontology 8th International Meeting, 2001年10月, 招待, 英語
  16. Neurotrophic Factors in Periodontal Disease, 栗原 英見, Modern Periodontology, 2001年07月, 招待, 日本語
  17. A Foe or a Friend?-歯周病における免疫応答の功罪をめぐって「血清抗体からみた歯周炎像」, 栗原 英見, 第43回秋季日本歯周病学会, 2000年10月, 招待, 日本語
  18. 歯周病の検査・診断, 栗原 英見, 第3回日本ヘルスケア歯科研究会, 2000年03月, 招待, 日本語
  19. Role of the growth factors in proliferation and differentiation of pulp cells, 栗原 英見, INTERNATIONAL ODONTOSTOMATOLOGIC CONGRESS, 1997年11月, 招待, 日本語
  20. Current Concept in Periodontal Therapy with Tooth Mobility Manifestation in Japan Oral Health 2000, 栗原 英見, Indonasia Society of Periodontology, 1997年08月, 招待, 日本語
  21. 口腔医学の立場から外傷歯の対応を考える, 栗原 英見, 2015年07月12日, 招待, 日本語, 日本外傷歯学会, 北九州市
  22. 多様な歯周組織欠損に応じた再生療法の開発, 栗原英見, 2016年08月29日, 招待, 日本語, 日本再生歯科医学会, 新潟
  23. 高齢者の歯周病治療の多面的考察, 栗原英見, 日本歯周病学会秋季学術大会, 2015年09月12日, 招待, 日本語, 日本歯周病学会
  24. 歯科医療における感染予防対策の新しい取り組み, 栗原英見, 北九州市歯科医療安全対策研修会, 2016年03月05日, 招待, 日本語, 北九州市, 小倉, 歯科医療における新しい感染予防対策推進の仕組みを紹介した。広島歯科医療安全支援機構の立上げの経緯と、活動内容について。医療事故防止と院内感染予防対策は診療所レベルであっても医療者の社会的な責任として、担保する必要がある。
  25. 凍結保存した間葉系幹細胞集塊Clumps of MSCs/ECM complexを用いた新規細胞移植療法の開発, 本池総太, 加治屋幹人, 竹下 慶, 竹脇 学, 小松奈央, 岩田倫幸, 武田克浩, 應原一久, 水野智仁,藤田剛, 栗原英見, 第60回春季日本歯周病学会学術大会, 2017年05月, 通常, 日本語
  26. 3次元培養骨髄間葉系幹細胞集塊 Clumps of a MSC/ECM complexの細胞分化を制御するメカノトランスダクション機構の解析, 小松奈央, 加治屋幹人, 本池総太, 竹脇 学, 竹下 慶, 應原一久, 武田克浩, 岩田倫幸, 藤田 剛, 栗原 英見, 第60回春季日本歯周病学会学術大会, 2017年05月, 通常, 日本語, 福岡
  27. 歯周病原細菌Porphyromonas gingivalis感染は補体因子C5aを介して関節炎を増悪させる, 宗永修一, 應原一久,加治屋幹人, 武田克浩,内田雄士,水野智仁,藤田 剛,栗原英見, 第60回春季日本歯周病学会学術大会, 2017年05月, 通常, 日本語
  28. Porphyromonas gingivalis感染関節リウマチモデルマウスにおける腸内細菌叢の解析, 濵本結太, 應原一久,宗永修一,加治屋幹人,水野智仁,藤田 剛,栗原 英見, 第60回春季日本歯周病学会学術大会, 2017年05月, 通常, 日本語
  29. 絹糸結紮による実験的歯周炎マウスモデルにおける接合上皮の経時的変化について, 竹村 翼, 藤田 剛,松田真司,加治屋幹人,内田雄士,芥川桂一,應原一久,武田克浩,水野智仁,栗原英見, 第60回春季日本歯周病学会学術大会, 2017年05月, 通常, 日本語
  30. 糖尿病マウスにおいて誘発された歯周炎に対するGlycyrrhizinの抗炎症作用の評価, 芥川桂一, 藤田 剛, 竹村 翼, 應原一久, 加冶屋幹人, 松田真司, 水野智仁, 栗原英見, 第38回日本炎症・再生医学会, 2017年07月, 通常, 日本語
  31. 3次元培養骨髄間葉系幹細胞集塊 Clumps of an MSC/ECM complexの細胞分化を制御するメカノトランスダクション機構の解析, 小松奈央, 加治屋幹人, 藤田 剛, 栗原英見, 第59回歯科基礎医学会学術大会, 2017年09月, 通常, 日本語
  32. 竹脇 学, 加治屋幹人, 武田克浩, 佐々木慎也, 本池総太, 小松奈央, 松田真司, 應原一久, 水野智仁, 藤田 剛, 栗原英見, 第12回アジア太平洋歯周病学会, 2017年09月, 通常, 英語
  33. 佐々木慎也, 武田克浩,竹脇 学,加治屋幹人,松田真司,水野智仁,藤田 剛,栗原 英見, 第12回アジア太平洋歯周病学会, 2017年09月, 通常, 英語
  34. 岡信 愛, 松田真司, 加治屋幹人, 藤田 剛, 栗原英見, 第12回アジア太平洋歯周病学会, 2017年09月, 通常, 英語
  35. bFGFを用いた歯周組織再生療法の症例報告と評価の標準化について, 武田克浩, 栗原英見, 日本歯周病学会中国四国3大学・日本臨床歯周病学会中国四国支部合同研修会, 2017年11月, 通常, 日本語
  36. 宗永修一, 應原一久,栗原英見, 第46回日本免疫学会学術集会, 2017年12月, 通常, 英語
  37. コウボクはPorphyromonas gingivalis mgl を介したメチルメルカプタン産生を抑制する, 佐藤陽子, 應原一久, 新谷智章, 北川雅恵, 小川郁子, 加冶屋幹人, 水野智仁, 藤田 剛,  栗原英見, 日本歯周病学会60周年記念京都大会, 2017年12月, 通常, 日本語
  38. FimA typeの異なるPorphyromonas gingivalis口腔投与が関節リウマチモデルマウスへ与える影響, 濵本結太, 應原一久, 宗永修一, 加治屋幹人, 水野智仁, 藤田 剛, 栗原 英見, 日本歯周病学会60周年記念京都大会, 2017年12月, 通常, 日本語
  39. 歯周病原細菌Porphyromonas gingivalis感染により増加した補体因子C5aが関節炎に及ぼす影響, 宗永修一, 應原一久, 加治屋幹人, 武田克浩, 水野智仁, 藤田 剛, 栗原英見, 日本歯周病学会60周年記念京都大会, 2017年12月, 通常, 日本語
  40. 歯周炎を誘発した糖尿病モデルマウスに対するGlycyrrhizinの作用について, 芥川桂一, 藤田 剛, 竹村 翼, 應原一久, 加冶屋幹人, 松田真司, 田利美沙子, 水野智仁,栗原英見, 日本歯周病学会60周年記念京都大会, 2017年12月, 通常, 日本語
  41. 間葉系幹細胞集塊Clumps of MSCs/ECM complexesは歯周組織再生を促進する, 竹脇 学, 加治屋幹人, 武田克浩, 佐々木慎也, 本池総太, 小松奈央, 松田真司, 應原一久, 水野智仁, 藤田 剛, 栗原英見, 日本歯周病学会60周年記念京都大会, 2017年12月, 通常, 日本語
  42. 脳由来神経栄養因子(BDNF)を用いた非外科的歯周治療に関する組織学的研究, 佐々木慎也, 武田克浩, 竹脇 学, 應原一久, 加治屋幹人, 松田真司, 水野智仁, 藤田 剛, 栗原 英見, 日本歯周病学会60周年記念京都大会, 2017年12月, 通常, 日本語
  43. 実験的歯周炎マウスにおける海馬領域の炎症反応, 古玉大祐, 松田真司, 藤田剛, 山脇洋輔, 加治屋幹人, 畑野紗希, 岡信 愛, 水野智仁,兼松 隆,栗原英見, 日本歯周病学会60周年記念京都大会, 2017年12月, 通常, 日本語
  44. 糖尿病マウスにおいて誘発された歯周炎に対するGlycyrrhizinの抗炎症作用の評価, 芥川桂一, 藤田剛,竹村 翼,應原一久,加冶屋幹人,松田真司,水野智仁, 栗原英見, 第50回広島大学歯学会総会, 2017年06月, 通常, 日本語
  45. 脳由来神経栄養因子(BDNF)を用いた非外科的歯周治療に関する組織学的研究, 佐々木慎也, 武田克浩,竹脇 学,應原一久,加治屋幹人,松田真司,水野智仁,藤田 剛,栗原英見, 第101回広島大学歯学会, 2017年10月, 通常, 日本語
  46. FimA typeの異なるPorphyromonas gingivalis口腔投与が関節リウマチモデルマウスへ与える影響, 濵本結太, 應原一久,久恒順三,宗永修一,加治屋幹人,水野智仁,藤田 剛,菅井基行,栗原英見, 第50回広島大学歯学会総会, 2017年06月, 通常, 日本語
  47. ランチョンセミナー 「歯周病と脳血管障害」, 栗原英見, 第20回日本臨床脳神経外科学会, 2017年07月, 通常, 日本語
  48. 「歯周病と全身の健康」, 栗原英見, 日本臨床歯周病学会 市民フォーラム, 2017年08月, 通常, 日本語
  49. シンポジウム, 栗原英見, 第12回アジア太平洋歯周病学会, 2017年09月, 通常, 英語
  50. 「京都宣言」, 栗原英見, 日本歯周病学会60周年記念京都大会, 2017年12月, 通常, 日本語

社会活動

その他社会貢献活動(広大・部局主催含)

  1. 広島県歯科衛生士会H29年度研修会, 「歯周病の全身への影響~感染、炎症の広がりとその捉え方~」, 広島県歯科衛生士会, 2017年/11月, 2017年/11月, 講師, セミナー・ワークショップ, 学術団体
  2. 東京歯科大学医局員セミナー, 「分子細胞学的歯周組織再生を考える」, 東京歯科大学, 2017年/11月, 2017年/11月, 東京歯科大学, 講師, 講演会, 研究者