藤高 一慶Kazunori Fujitaka

Last Updated :2019/07/01

所属・職名
大学院医系科学研究科(医) (医学)分子内科学 講師
メールアドレス
fujikazuhiroshima-u.ac.jp

基本情報

学位

  • 博士(医学) (広島大学)

研究分野

  • 医歯薬学 / 内科系臨床医学 / 呼吸器内科学

教育活動

授業担当

  1. 2019年, 学部専門, 集中, 器官・システム病態制御学I
  2. 2019年, 博士課程・博士課程後期, セメスター(前期), がん診療各論
  3. 2019年, 博士課程・博士課程後期, 1ターム, がん診療各論

研究活動

学術論文(★は代表的な論文)

  1. SK-216, an Inhibitor of Plasminogen Activator Inhibitor-1, Limits Tumor Progression and Angiogenesis, MOLECULAR CANCER THERAPEUTICS, 12巻, 11号, pp. 2378-2388, NOV 2013
  2. Carboplatin AUC and gamma-glutamylcysteine synthetase gene expression in peripheral mononuclear cells of lung cancer patients., Anticancer Reserch, 21巻, 6A号, pp. 3933-6, 20011201
  3. Association between expression of MRP3 gene and exposure to platinum drug in lung cancer., International journal of cancer, 93巻, 4号, pp. 584-9, 20010815
  4. Glutathione S-transferase-pi gene expression and platinum drug exposure in human lung cancer., Cancer Letter, 156巻, 1号, pp. 93-9, 20000801
  5. Malignant paraganglioma arising from the posterior mediastinum: a case report and review of the literature., 広島大学医学雑誌, 48巻, 4号, pp. 123-12, 19991201
  6. 特発性間質性肺炎に合併し広範囲な浸潤影をきたした肺腺癌の一例, 日本呼吸器学会雑誌, 39巻, 1号, pp. 35-9, 20010101
  7. Usefulness monitoring of circulating KL-6 in patients with advanced non-small cell lung cancers treated with gefitinib therapy., International journal of cancer, 122巻, 11号, pp. 2612-2620, 20080601
  8. Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice, J Pharmacol Exp Ther, 328巻, 1号, pp. 55-61, 20090101
  9. Suppression of plasminogen activatior inhibitor-1 by RNA interference attenuates pulmonary fibrosis., Thorax, 65巻, 4号, pp. 334-340, 20100401
  10. Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy., Cancer Chemother Pharmacol, 67巻, 6号, pp. 1465-9, 20110101
  11. Regresson of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy., Hiroshima J. Med. Sci, 60巻, 1号, pp. 7-9, 20110301
  12. Phase I study docetaxel plus S-1 combination chemotherapy for recurrent non-small cell lung cancer., Oncology Letters, 2巻, pp. 167-170, 20110101
  13. Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease, Respir Res, 12巻, pp. 97-107, 20110701
  14. Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., Am J Physiol Lung Cell Mol Physiol, 301巻, 6号, pp. L908-916, 20110901
  15. 肺性肥大性骨関節症を合併した肺多形癌の1例, 日本呼吸器学会雑誌, 49巻, 10号, pp. 765-768, 20111001
  16. Association between expression of the MRP3 gene and exposure to platinum drugs in lung cancer, INTERNATIONAL JOURNAL OF CANCER, 93巻, 4号, pp. 584-589, AUG 15 2001
  17. SGLT gene expression in primary lung cancers and their metastatic lesions, JAPANESE JOURNAL OF CANCER RESEARCH, 92巻, 8号, pp. 874-879, AUG 2001
  18. Induction of cytochrome P450 3A4 by docetaxel in peripheral mononuclear cells and its expression in lung cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 48巻, 1号, pp. 42-46, JUL 2001
  19. Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion, INTERNAL MEDICINE, 40巻, 10号, pp. 1020-1023, OCT 2001
  20. Carboplatin AUC and gamma-glutamylcysteine synthetase gene expression in peripheral mononuclear cells of lung cancer patients, ANTICANCER RESEARCH, 21巻, 6A号, pp. 3933-3936, NOV-DEC 2001
  21. Usefulness of the modified lavage technique of Bingisser and KL-6 monitoring in a patient with pulmonary alveolar proteinosis, INTERNAL MEDICINE, 41巻, 5号, pp. 381-385, MAY 2002
  22. A case of micronodular pneumocyte hyperplasia diagnosed through lung biopsy using thoracoscopy, RESPIRATION, 69巻, 3号, pp. 277-279, MAY-JUN 2002
  23. KL-6 as an indicator for lymphocytic interstitial pneumonia (LIP) in a human T lymphotrophic virus type 1 (HTLV-1) carrier, ANNALS OF HEMATOLOGY, 81巻, 8号, pp. 474-477, AUG 2002
  24. Investigating the relationship between serum thrombopoietin kinetics and the platelet-sparing effect: A clinical pharmacological evaluation of combined paclitaxel and carboplatin in patients with non-small cell lung cancer, ONCOLOGY REPORTS, 11巻, 6号, pp. 1225-1231, JUN 2004
  25. Validation of the limited-sampling models for carboplatin AUC in combination chemotherapy with taxanes, ANTICANCER RESEARCH, 24巻, 3B号, pp. 1911-1914, MAY-JUN 2004
  26. Neutropenic enterocolitis in lung cancer: A report of two cases and a review of the literature, INTERNAL MEDICINE, 44巻, 5号, pp. 467-470, MAY 2005
  27. Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors, INTERNATIONAL JOURNAL OF CANCER, 122巻, 11号, pp. 2612-2620, JUN 1 2008
  28. A case of pulmonary asbestosis presenting with temporal arteritis involving multiple medium-sized vessels, MODERN RHEUMATOLOGY, 18巻, 1号, pp. 100-104, FEB 2008
  29. Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis, THORAX, 65巻, 4号, pp. 334-340, APR 2010
  30. Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 67巻, 6号, pp. 1465-1469, JUN 2011
  31. Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease, RESPIRATORY RESEARCH, 12巻, JUL 26 2011
  32. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients, RESPIROLOGY, 20巻, 1号, pp. 87-94, JAN 2015
  33. MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model, CANCER SCIENCE, 106巻, 7号, pp. 921-928, JUL 2015
  34. Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung, PHARMACEUTICAL RESEARCH, 32巻, 12号, pp. 3877-3885, DEC 2015
  35. Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-beta-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts, PLOS ONE, 11巻, 2号, FEB 9 2016
  36. MUC1 gene polymorphisms are associated with serum KL-6 levels and pulmonary dysfunction in pulmonary alveolar proteinosis, EUROPEAN RESPIRATORY JOURNAL, 42巻, 2013
  37. COMPARISON OF KL-6, SP-A, SP-D, 8-ISOPROSTANE, MMP-9, AND TIMP-1 AS SERUM BIOMARKERS FOR PATIENTS WITH COMBINED PULMONARY FIBROSIS AND EMPHYSEMA, RESPIROLOGY, 18巻, pp. 58-58, 2013
  38. BRONCHOALVEOLAR LAVAGE CELLULAR PATTERN CAN PREDICT THE PROGNOSIS OF PATIENTS WITH CHRONIC HYPERSENSITIVITY PNEUMONITIS, RESPIROLOGY, 18巻, pp. 80-80, 2013
  39. CHARACTERISTICS OF INSPIRATORY AND EXPIRATORY REACTANCE IN IDIOPATHIC PULMONARY FIBROSIS, RESPIROLOGY, 18巻, pp. 137-137, 2013
  40. ANTITUMOR EFFECT OF A HUMANIZED ANTIBODY AGAINST AMINOPEPTIDASE N IN MOUSE TUMOR MODELS, RESPIROLOGY, 18巻, pp. 151-151, 2013
  41. INCREASED OF RECEPTOR TYPE TYROSINE KINASE ROS1 IN INTERSTITIAL LUNG DISEASE, RESPIROLOGY, 18巻, pp. 200-200, 2013
  42. A retrospective study comparing pemetrexed with taxanes as front-line cytotoxic chemotherapy for lung adenocarcinoma, ANNALS OF ONCOLOGY, 26巻, pp. 123-123, 2015
  43. Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis, DISEASE MARKERS, 2016
  44. Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers, INHALATION TOXICOLOGY, 28巻, 8号, pp. 343-348, JUL 2016
  45. Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma, CANCER RESEARCH, 76巻, 11号, pp. 3285-3294, JUN 1 2016
  46. 薬剤性浮腫のためクリゾチニブが継続不能となり、アレクチニブへの変更投与により副作用なく部分奏功が得られたEML4-ALK融合遺伝子陽性肺腺癌の1例, 肺癌, 55巻, pp. 212-217
  47. 2次治療としてカルボプラチンとナブパクリタキセルによる化学療法が奏効した胸腺癌の1例, 日本胸部臨床, 74巻, pp. 900-908
  48. Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals, FREE RADICAL BIOLOGY AND MEDICINE, 106巻, pp. 1-9, MAY 2017
  49. AGER gene polymorphisms and soluble receptor for advanced glycation end product in patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 22巻, 5号, pp. 965-971, JUL 2017
  50. Chronic Intestinal Pseudo-obstruction and Orthostatic Hypotension Associated with Small Cell Lung Cancer that Improved with Tumor Reduction after Chemoradiotherapy, INTERNAL MEDICINE, 56巻, 19号, pp. 2627-2631, 2017
  51. AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma, ONCOTARGET, 8巻, 55号, pp. 94382-94392, NOV 7 2017
  52. Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis, INTERNAL MEDICINE, 56巻, 24号, pp. 3327-3331, 2017
  53. The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 81巻, 1号, pp. 131-139, JAN 2018
  54. FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 123巻, pp. 105-109, FEB 2017
  55. Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma, LUNG CANCER, 119巻, pp. 21-24, MAY 2018
  56. Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma, EUROPEAN RESPIRATORY JOURNAL, 51巻, 5号, MAY 1 2018
  57. Use of proton pump inhibitors is associated with increased mortality due to nosocomial pneumonia in bedridden patients receiving tube feeding., Geriatr Gerontol Int.
  58. Feasibility and Safety of CT-guided Intrathoracic and Bone Re-biopsy for Non-small Cell Lung Cancer., Anticancer Res.

著書等出版物

  1. 2003年10月, シュミレーション内科 呼吸器疾患を探る(腫瘍編) , 永井書店, 2003年, 10, 教科書, 共編著, 藤高 一慶 礒部威 山崎正弘
  2. 2009年11月, まんがで読み解く呼吸器症例100, メディカルレビュー社, 2009年, 教科書, その他, 日本語
  3. 2012年08月, エビデンスに基づく呼吸器看護ケア関連図, 中央法規出版, 2012年, 教科書, その他, 日本語
  4. 2013年05月, 低線量CTによる肺がん検診マニュアル, ヌンク, 2013年, 教科書, その他, 日本語

社会活動

委員会等委員歴

  1. 広島市がん検診精度管理連絡会議委員, 2018年02月, 2020年01月, 広島市健康福祉局
  2. (財)広島原爆障害対策協議会, 2018年04月, 2019年03月, 胸部レントゲン読影委員

学術会議等の主催

  1. 第55回日本肺癌学会中国・四国支部会, 合同事務局, 2016年07月, 2016年07月
  2. 第26回呼吸器内視鏡学会中国四国支部会, 合同事務局, 2017年10月

その他社会貢献活動(広大・部局主催含)

  1. 肺がん治療の選択肢  放射線、化学療法、がん免疫療法, 中国新聞社, 市民公開講座『進歩する肺癌治療~手術、放射線治療、化学療法、新しい免疫療法について~』, 2016年/07月, 2016年/07月, 広島県JAビル, 講師, シンポジウム・パネルディスカッション・対話型集会・市民会議, 社会人・一般
  2. 肺がん治療の最前線~広島編 地域医療の現場から2017, 広島ホームテレビ, 医TVスペシャル, 2017年/04月/01日, 2017年/04月/01日, 取材協力, テレビ・ラジオ番組