菅井 基行Motoyuki Sugai

Last Updated :2017/09/22

所属・職名
大学院医歯薬保健学研究科(歯) 歯学講座 教授
メールアドレス
sugaihiroshima-u.ac.jp
その他連絡先
広島市南区霞1丁目2番3号 基礎社会医学棟 6階6階
TEL:082−257−5636 FAX:082−257−5639
自己紹介
こんにちは。細菌学の菅井です。

基本情報

主な職歴

  • 1987年10月01日, 1994年06月30日, 広島大学, 歯学部, 助手
  • 1994年07月01日, 1999年12月31日, 広島大学, 歯学部, 助教授
  • 2000年01月01日, 2002年03月31日, 広島大学, 歯学部, 教授
  • 2002年04月01日, 2012年03月31日, 広島大学, 大学院医歯薬学総合研究科, 教授
  • 2004年04月01日, 2012年03月31日, 広島大学, (併)大学院医歯薬学総合研究科副研究科長
  • 2012年04月01日, 広島大学, (併)歯学部長
  • 2012年04月01日, 広島大学, 大学院医歯薬保健学研究院, 教授

学歴

  • 広島大学, 歯学研究科, 歯学基礎系, 日本, 1984年04月, 1987年09月
  • 広島大学, 歯学部, 歯学科, 日本, 1978年04月, 1984年03月

学位

  • 歯学博士 (広島大学)

担当主専攻プログラム

  • 歯学プログラム
  • 医学プログラム
  • 口腔保健学プログラム
  • 口腔工学プログラム

研究分野

  • 医歯薬学 / 基礎医学 / 細菌学(含真菌学)

研究キーワード

  • EDIN
  • 自己溶解酵素
  • rho
  • 黄色ブドウ球菌
  • ADPリボシル化

所属学会

  • 日本細菌学会
  • 日本化学療法学会
  • 日本感染症学会
  • American Society for Microbiology
  • 日本研究皮膚科学会
  • 歯科基礎医学会

教育活動

授業担当

  1. 2017年, 教養教育, 3ターム, 細胞科学[1歯歯,1歯口]
  2. 2017年, 学部専門, セメスター(後期), 歯学概論
  3. 2017年, 学部専門, セメスター(前期), 微生物学
  4. 2017年, 学部専門, セメスター(後期), 微生物学
  5. 2017年, 学部専門, セメスター(前期), 口腔微生物学基礎実習
  6. 2017年, 学部専門, セメスター(後期), 専門コースワーク
  7. 2017年, 学部専門, セメスター(後期), 細菌学演習
  8. 2017年, 学部専門, セメスター(前期), 細菌学実習
  9. 2017年, 学部専門, セメスター(後期), 細菌学実習
  10. 2017年, 学部専門, セメスター(前期), 細菌学実習
  11. 2017年, 学部専門, セメスター(前期), 微生物学・口腔微生物学
  12. 2017年, 学部専門, セメスター(後期), 専門コースワーク
  13. 2017年, 学部専門, セメスター(前期), 微生物学・口腔微生物学
  14. 2017年, 学部専門, セメスター(後期), 専門コースワーク
  15. 2017年, 修士課程・博士課程前期, セメスター(後期), 生体防御学
  16. 2017年, 修士課程・博士課程前期, セメスター(前期), 医歯科学演習(細菌学)
  17. 2017年, 修士課程・博士課程前期, セメスター(後期), 医歯科学演習(細菌学)
  18. 2017年, 修士課程・博士課程前期, セメスター(前期), 医歯科学特別研究(細菌学)
  19. 2017年, 修士課程・博士課程前期, セメスター(後期), 医歯科学特別研究(細菌学)
  20. 2017年, 博士課程・博士課程後期, セメスター(前期), 口腔健康科学特講Ⅰ
  21. 2017年, 博士課程・博士課程後期, セメスター(前期), 細菌学特別演習
  22. 2017年, 博士課程・博士課程後期, セメスター(後期), 細菌学特別演習
  23. 2017年, 博士課程・博士課程後期, セメスター(前期), 細菌学特別実験
  24. 2017年, 博士課程・博士課程後期, セメスター(後期), 細菌学特別実験

研究活動

学術論文(★は代表的な論文)

  1. Cytolethal distending toxin induces caspase-dependent and -independent cell death in MOLT-4 cells, INFECTION AND IMMUNITY, 76巻, 10号, pp.4783-pp.4791, OCT 2008
  2. Staphylococcus aureus MazF Specifically Cleaves a Pentad Sequence, UACAU, Which Is Unusually Abundant in the mRNA for Pathogenic Adhesive Factor SraP, JOURNAL OF BACTERIOLOGY, 191巻, 10号, pp.3248-pp.3255, MAY 2009
  3. Bacitracin sensing and resistance in Staphylococcus aureus, FEMS MICROBIOLOGY LETTERS, 320巻, 1号, pp.33-pp.39, JUL 2011
  4. Growth-phase dependence of susceptibility to antimicrobial peptides in Staphylococcus aureus, MICROBIOLOGY-SGM, 157巻, pp.1786-pp.1797, JUN 2011
  5. Emergence in Japan of an imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae carrying bla(IMP-6), DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 72巻, 1号, pp.109-pp.112, JAN 2012
  6. Rapid detection of bla(IMP-6) by amplification refractory mutation system, JOURNAL OF MICROBIOLOGICAL METHODS, 88巻, 1号, pp.182-pp.184, JAN 2012
  7. A novel metallo-beta-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem, DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 76巻, 1号, pp.119-pp.121, MAY 2013
  8. Meropenem Resistance in Imipenem-Susceptible Meropenem-Resistant Klebsiella pneumoniae Isolates Not Detected by Rapid Automated Testing Systems, JOURNAL OF CLINICAL MICROBIOLOGY, 51巻, 8号, pp.2735-pp.2738, AUG 2013
  9. Identification and Characterization of a Novel aac(6 ')-Iag Associated with the bla(IMP-1)-Integron in a Multidrug-Resistant Pseudomonas aeruginosa, PLOS ONE, 8巻, 8号, AUG 12 2013
  10. 緑膿菌によって形成されたbiofilmの抗菌剤透過性, Bacterial Adherence研究, 12巻, pp.26-pp.29, 19980401
  11. 黄色ブドウ球菌の産生する表皮細胞分化抑制因子, 皮膚病臨床, 14巻, 11号, pp.954-pp.958, 19920401
  12. Staphylococcal ADP-ribosyltransferase-sensitive small G protein is involved in drefeldin A action, The Journal of Biological Chemistry, 267巻, 30号, pp.21297-pp.21299, 19920401
  13. Bacterial ADP-ribosyl transferase with a substrate specificity of the Rho protein disassembles the Golgi apparatus in Vero cells and mimics the action of brefeldin A., Proceedings of National Academy of Science in U. S. A., 89巻, pp.8903-pp.8907, 19920401
  14. Export of the outer membrane lipoprotein is defective in sec D sec E, and sec F mutants of Escherichiacoli, JOURNAL OF BACTERIOLOGY, 174巻, 8号, pp.2511-pp.2516, 19920401
  15. Epidermal Cell differentiation inhibitor ADP ribosylates small GTP-binding proteins and induces hyperplasia of epidermis, The Journal of Biological Chemistry, 267巻, 4号, pp.2600-pp.2604, 19920401
  16. 表皮細胞分化抑制因子, 臨床検査, 35巻, 13号, pp.1345-pp.1346, 19910401
  17. Molecular cloning and sequencing of the epidermal cell differentiation inhibitor gene from staphylococcus aureus, Biochemical and Biophysical Research Communication, 174巻, 2号, pp.459-pp.464, 19910401
  18. Processing of lipid-modified prolipoprotein requires energy and sec gene products in vivo, JOURNAL OF BACTERIOLOGY, 175巻, 19号, pp.6113-pp.6117, 19930401
  19. Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifyies the small GTP-binding proteins Rho involved in assembly of actin stress fibers, Proceedings of National Academy of Science U.S.A., 91巻, pp.3814-pp.3818, 19940401
  20. Effect of combination of oxacillin and non-β-lactam antibiotics on methicillin-resistant Staphylococcus aureus, Journal of Antimicrobial Chemotherapy, 33巻, pp.1155-pp.1163, 19940401
  21. The effect of Triton X-100 on the in-vitro susceptibility of methicillin-resistant Staphylococcus aureus to oxacillin, Journal of Antimicrobial Chemotherapy, 34巻, pp.885-pp.897, 19940401
  22. Isolation and characterization of Staphylococcus aureus mutants which form altered cell clusters, Microbiology and Immunology, 38巻, 12号, pp.995-pp.999, 19940401
  23. A staphylococcus aurens autolysin that has an N-acetylmaramoyl-L-alanine amidase clomain and an endo-β-N-acetyl-glucosaminidase domain : cloning, sequence analysis, and characterization, Proceedings of the National Academy of Sciences of USA, 92巻, pp.285-pp.289, 19950401
  24. Identification of endo-β-N-acetylglucosaminidase and N-acetylmuramyl-L-alanine amidase as cluster-despersing enzymes in Staphylococcus auraus, JOURNAL OF BACTERIOLOGY, 177巻, 6号, pp.1491-pp.1496, 19950401
  25. Alteration of bacteriolytic enzyme profile of Staphylococcus aureus during growth, Microbiology and Immunology, 39巻, 8号, pp.629-33, 19950401
  26. 黄色ブドウ球菌が産生する表皮細胞分化抑制因子(EDIN)の発見及びその作用機序についての研究, 日本細菌学雑誌, 50巻, 4号, pp.937-46, 19950401
  27. 低分子量G蛋白質rhoを修飾する細菌毒素スーパーファミリー, 広島大学歯学雑誌, 27巻, pp.491-92, 19950401
  28. Triton X-100 alters the resistance level of methicillin-resistaut Staphylococcus aurens to oxacillin, FEMS Microbiology ltters, 134巻, pp.209-12, 19950401
  29. An autolysin ring associated with cell separtion of Staphylococcus aureus, JOURNAL OF BACTERIOLOGY, 178巻, 6号, pp.1565-71, 19960401
  30. ブドウ球菌が産生する溶菌酵素, 日本細菌学雑誌, 52巻, 2号, pp.461-pp.473, 19970401
  31. 肥満細胞からのヒスタミン開口放出を制御するG蛋白質の研究:Rhoの役割, セラピューティック・リサーチ, 18巻, Suppl.1号, pp.58-pp.64, 19970401
  32. Purification and molecular characterization of glycylglycine eudopeptidase produced by Staphylococcus capitis EPK1, J. Bacteriol., 174巻, 4号, pp.1193-pp.1202, 19970401
  33. Subcellular localization of the major autolysin, ATL and its processed proteins in Staphylococcus aureus, Microbiol. Immunol., 41巻, 6号, pp.469-pp.479, 19970401
  34. Role of guanine nucleotide-binding proteins-ras family or trimeric proteins or both-in Ca sensitization of smoork muscle, Proc. Natl. Acad. Sci. USA, 93巻, pp.1340-pp.1345, 19960401
  35. Effect of the growth rate of Pseudomonas aeruginosa biofilms on the susceptibility to antimicrobial agents, Chemotherapy, 43巻, pp.137-pp.141, 19970401
  36. Permeabilities of antimicrobial agents through Pseudomonas aeruginosa biofilms : simple method, Chemothrapy, 43巻, pp.340-pp.345, 19970401
  37. Bacterial toxins block endothelial wound repair : eveidence that Rho GTPases control cytoskeletal rearrangements in migrating endothelial cells., Arteriosclerosis= Thrombosis= and Vascular Biology, 17巻, pp.1623-pp.1629, 19970401
  38. Localized perforation of the cell wall by a major autolysinDatl gene products and the onset of penicillin-induced lysis of Staphylococcus aureus, JOURNAL OF BACTERIOLOGY, 179巻, pp.2958-pp.2962, 19970401
  39. Effects of various types of Triton X on the susceptibilities of methicillin-resistant staphylococci to oxacillin., FEMS Microbiology Letters, 153巻, pp.327-pp.331, 19970401
  40. epr, which encodes glycylglycine endopeptidase resistance, is homologous to femAB and affects serine content of peptidoglycan cross bridges in Staphylococcus capitis and Staphylococcus aureus, JOURNAL OF BACTERIOLOGY, 179巻, pp.4311-pp.4318, 19970401
  41. Cloning and characterization of the fmt gene which affects the methicillin resistance level and autolysis in the presence of Triton X-100 in methicillin-resistant Staphylococcus aureus, Antimicrobial Agents and Chemotherapy, 41巻, pp.2355-pp.2361, 19970401
  42. A long-term survey of methicillin-resistant Staphylococcus aureus in the oral cavity of children., Microbiology and Immunology, 41巻, pp.681-pp.686, 19970401
  43. Peptidoglycan Hydrolases of the Staphylococci, Journal of Infection and Chemotherapy, 3巻, pp.113-pp.127, 19970401
  44. Expression and purification of epidermal cell differentiation inhibitor(EDIN)from B. subtilis, Protein Expression and Purification, 12巻, pp.284-pp.290, 19980401
  45. Zymographic characterization of Staphylococcus aureus cell wall., Microbiology and Immunology, 42巻, pp.231-pp.235, 19980401
  46. A triazine dye, cibacron blue F3GA, decreases oxacillin resistance levels of methicillin-resistant Staphylococcus aureus, Antimicrobial Agents and Chemotherapy, 42巻, pp.1278-pp.1280, 19980401
  47. Superantigen production by Staphylococcus aureus in Psoriasis, Dermatology, 196巻, pp.194-pp.198, 19980401
  48. The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans is a cytolethal distending toxin, Infection and Immunity, 66巻, pp.5008-pp.5019, 19980401
  49. Identification and molecular characterization of a gene homologous to epr(endopeptidase resistance gene)in Staphylococcus aureus., Gene, 224巻, pp.67-pp.75, 19980401
  50. The mechanism of sensitizing effect of a triazine dye, cibacron blue F3GA, on methicillin-resistant Staphylococcus aureus to oxacillin., Hiroshima Journal of Medical Sciences, 47巻, pp.73-pp.83, 19980401
  51. Expression analysis of the autolysin gene(atl) of Staphylococcus aureus., Microbiology and Immunology, 42巻, pp.655-pp.659, 19980401
  52. マスト細胞からのヒスタミン開口放出を制御する低分子量G蛋白質の研究, Therapeutic Research, 19巻, S-1号, pp.161-pp.166, 19980401
  53. 低分子量G蛋白質を標的とする細菌毒素, 化学と生物, 36巻, pp.428-pp.435, 19980401
  54. Cloning of the gene encoding the Actinobacillus actinomycetemcomitans serotype b OmpA-like outer membrane protein., Infection and Immunity, 67巻, pp.942-pp.945, 19990401
  55. Effect of the growth rate of Pseudomonas aeruginosa biofilms on the susceptibiligy to antimicrobial agents ; beta-lactams and fluoroquinolones., Chemotherapy, 45巻, pp.28-pp.36, 19990401
  56. Expression of osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human dental mesenchymal cells and epithelial cells., Journal of Bone and Mineral Research, 14巻, pp.1486-pp.1492, 19990401
  57. Cloning and characterization of a gene, pbpF, encoding a new penicillin-binding protein, PBP2B, in Staphylococcus aureus, Antimicrobial Agents and Chemotherapy. Apy, 43巻, pp.1578-pp.1583, 19990401
  58. Characterization of fmtA genethat modulates the expression of methicillin resistance in Staphylococcus aureus, Antimicrobial Agents and Chemotherapy, 43巻, pp.2121-pp.2125, 19990401
  59. Selective diapedesis of Th1 cells induced by endothelial cell RANTES., Journal of Immunology, 163巻, pp.3269-pp.3278, 19990401
  60. Cytotoxic necrotizing factor type 2 produced by pathogenic Escherichia coli deamidates a Gln residue in the conserved G-3 domain of the Rho family and preferentially inhibits the GTPase activity of RhoA and Rac1., Infection and Immunity, 67巻, pp.6550-pp.6557, 19990401
  61. Pseudomonas-induced necrotizing gingivostomatitis., Oral Surgery= Oral Medicine and Oral Pathology, 88巻, pp.644-pp.645, 19990401
  62. Triton X-100-induced lipoteichoic acid release is correlated with the methicillin resistance in Staphylococcus aureus., FEMS Microbiology Letters, 182巻, pp.77-pp.79, 19990401
  63. Tn551 mediated insertional inactivation of the fmtB gene encoding a cell wall associated protein abolishes methicillin resistance in Staphylococcus aureus., Journal of Antimicrobial Chemotherapy, 45巻, pp.421-pp.431, 20000401
  64. Effect of clarithromycin on Pseudomonas aeruginosa biofilms., Chemotherapy, 46巻, pp.36-pp.42, 20000401
  65. Triton X-100-induced lipoteichoic acid release is correlated with the methicillin resistance in Staphylococcus aureus., FEMS Microbiology Letters, 182巻, pp.77-pp.79, 20000401
  66. Identification of a fmtA-like gene that has similarity to other PBPs and beta-lactamase in Staphylococcus aureus., FEMS Microbiol. Letters, 188巻, pp.35-pp.39, 20000401
  67. Modification of autolysis by synthetic peptides derived from the presumptive binding domain of Staphylococcus aureus autolysin., Microbiology and Immundogy, 44巻, pp.463-pp.472, 20000401
  68. Phage conversion of exfoliative toxin A production in Staphylococcus aureus., Molecular Microbiology, 38巻, pp.694-pp.705, 20000401
  69. Acquired subglottic stenosis caused by methicillin resistant Staphylococcus aureus that produce epidermal cell differentiation inhibitor., Fetal and Neonatal, 84巻, pp.F38-39, 20010401
  70. Distribution of Rho-Inactivating EDIN Toxins in Clinical Staphylococcus aureus Isolates., Journal of Infectious Diseases, 184巻, pp.785-pp.788, 20010401
  71. Permeation of Antimicrobial Agents through Pseudomonas aeruginosa Biofilms: A Simple Method., Chemotherapy, 43巻, pp.340-pp.345, 19970401
  72. Cloning and sequenicnig of the gene, fmtC, which affects oxacillin resistance in methicillin-resistant Staphylococcus aureus, FEMS Microbiol. Lett., 203巻, pp.49-pp.54, 20010801
  73. Cloning and characterization of the fmt gene which affects the methicillin resistance level and autolysis in the presence of Triton X-100 in methicillin-resistant Staphylococcus aureus., Antimicrob. Agents Chemother., 41巻, 11号, pp.2355-pp.2361, 19971101
  74. A long-term survey of methicillin-resistant Staphylococcus aureus in the oral cavity of children, Microbiolgy and Immunology, 41巻, 9号, pp.681-pp.686, 19970401
  75. A triazine dye, cibacron blue 3G-A induces Staphylococcus aureus to form giant clusters., FEMS Microbiol. Lett., pp.67, 175-178, 19900401
  76. Cloning and characterization of the fmt gene which affects the methicillin resistance level and autolysisin the presence of Triton X-100 in methicillin - resistant Staphylococcus aureus., Antimicrobial Agents and Chemotherapy. Apy, 41巻, 11号, pp.2355-pp.2361, 19971101
  77. Zymographic characterization of Staphylococcus aureus cell wall ., Microbiology and Immunology, 42巻, 3号, pp.231-pp.235, 19980401
  78. Atriazine dye, cibacron blue F3GA, decreases oxacillin resistance levels in methicillin-resistant Staphylococcus aureus, Antimicrobial agent and chemotherapy, 42巻, 5号, pp.1278-pp.1280, 19980401
  79. Chracterization of fmtA, a gene that modulates the expression of methicillin resistance in Staphylococcus aureus., Antimicrobial agent and chemotherapy, 43巻, 9号, pp.2121-pp.2125, 19990901
  80. Cloning and characterization of a gene, gene, pbpF, encoding a new penicillin-binding protein, PBP2B, in Staphylococcus aureus., Antimicrobial agent and chemotherapy, 43巻, 7号, pp.1578-pp.1583, 19990701
  81. Triton X-100- induced lipoteichoic acid release is correlated with the methicillin resistance in Staphylococcus aureus., FEMS Microbiology Letters, 182巻, pp.77-pp.79, 20000401
  82. Tn551-mediated insertional in activation of the fmtB gene encoding a cell wall-associated protein abolishes methicillin resistance in Staphylococcus aureus., Journal of Antimicrobial Chemotherapy, 45巻, pp.421-pp.431, 20000401
  83. Purification of Staphylococcal exfoliative toxin by high speed liquid chromatography:, Zentralblatt fur Bakteriologie, 273巻, pp.5-pp.11, 19900401
  84. A novel epidermal cell differentiation inhibitor (EDIN): Purification and characterization from Staphylococcus aureus:, Biochem. Biophys. Res. Commun., 173巻, pp.92-pp.98, 19900401
  85. Suppression of penicillin-induced lysis of Staphylococcus aureus by cibacron blue 3G-A:, FEMS Microbiology Letters, 80巻, pp.151-pp.154, 19910401
  86. Molecular cloning and sequencing of the epidermal cell differentiation inhibitor gene from Staphylococcus aureus, Biochem. Biophys. Res. Commun., 174巻, pp.459-pp.464, 19910401
  87. Epidermal cell differentiation inhibitor ADP-ribosylates small GTP-binding proteins and induces hyperplasia of epidermidis, J. Biol. Chem., 267巻, 4号, pp.2600-pp.2604, 19920401
  88. epr, which encodes glycylglycine endopeptidase resistance, is homologous to femAB and affects serine content of peptidoglycan crossbridges in Staphylococcus capitis and Staphylococcus aureus., J. Bacteriol., 179巻, pp.4311-pp.4318, 19970401
  89. Purification of Staphylococcal exfoliative toxin by high pressure liquid chromatography, Zbl. Bakt., 273巻, pp.5-pp.11, 19900401
  90. Expression of IL-1b and IL-8 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans, Cytokine, 14巻, 3号, pp.152-pp.161, 20010501
  91. Expression of osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human dental mesenchymal cells and epithelial cells, J. Bone Miner. Res., 14巻, 9号, pp.1486-pp.1492, 19990901
  92. Effect of combination of oxacillin and non-beta-lactam antibiotics on methicillin-resistant Staphylococcus aureus, J. Antimicrob. Chemother., 33巻, 6号, pp.1155-63, 19940401
  93. Effects of various types of Triton X on the susceptibilities of methicillin-resistant staphylococci to oxacillin, FEMS Microbiol. Lett., 153巻, 2号, pp.327-31, 19970401
  94. A long-term survey of methicillin-resistant Staphylococcus aureus in the oral cavity of children, Microbiol. Immunol., 41巻, 9号, pp.681-6, 19970401
  95. Identification of Staphilococcus aureus etd pathogenecity island which encodes a novel exfoliative toxin, ETD, and EDIN-B., Infection and Immunity, 70巻, pp.5835-pp.5845, 20020401
  96. Permeation of Antimicrobial Agents through Pseudo monas aerugiuosa Biofilms,A Simple Method, Chemotherapy, 43巻, pp.340-pp.345, 19970401
  97. 尿中分離菌におけるstaphyfococuus epidermidis Intercellular Adbesion Gene(ica gene)とbiofilm形成能, Bacterial Adherence研究   The Japanese Association for Bacterial Adherence Research, 14巻, pp.40-pp.43, 20000401
  98. 1996年の外来、入院患者における尿路感染症分離菌の検討およびPseudomonas aeruginosaゲノムタイピング解析, 西日本泌尿器科, 64巻, 4号, pp.260-pp.268, 20020401
  99. Enteropathogenic and enterohaemorrhagic Escherichia coli deliver a novel effector called Cif, which blocks cell cycle G2/M transition., Mol. Microbiol., 50巻, pp.1553-pp.1567, 20030401
  100. Actinobacillus actinomycetemcomitans CDT insuces cell cycle arrest in primary culture of human gingival fibroblasts. M.Ohara, Y.Ueno, H.Shiba, S.Nishikubo, M.Ikura, H.Kurihara, H.Komatsuzawa, M.Sugai. Dentistry in Japan. 40: 18-22. 2004., Dentistry in Japan, 40巻, pp.18-pp.22, 20040401
  101. Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-cell lines., Infection and Immunity, 72巻, pp.871-879,, 20040401
  102. Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans, Molecular Microbiology, 50巻, 4号, pp.1125-pp.1139, 20030901
  103. Zymographic characterization of bacteriolytic enzymes produced by oral streptococci., Microbiology and Immunology, 48巻, 6号, pp.465-pp.469, 20040401
  104. Increased glycan chain length distribution and decreased susceptibility to moenomycin in a vancomycin-resistant Staphylococcus aureus mutant., Antimicrob. Agents Chemother., 46巻, 1号, pp.75-pp.81, 20020101
  105. Irsogladine maleate influences the response of gap junctional intercellular communication and IL-8 of human gingival epithelial cells following periodontopathogenic bacterial challenge., Biochem. Biophys. Res. Commun., 333巻, pp.502-pp.507, 20050401
  106. Cytolethal Distending Toxin and its implication in periodontal diseases., J. Oral. Biosci., 47巻, pp.18-pp.24, 20050401
  107. Single Nucleotide Polymorphism in the Cytolethal Distending Toxin B Gene Confers Heterogeneity in the Cytotoxicity of Actinobacillus actinomycetemcomitans, Infect. Immun., 74巻, pp.7014-pp.7020, 20060401
  108. Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases, Curr Pham Des, 13巻, 30号, pp.3084-pp.3095, 20070101
  109. First isolation of blaIMP-7 in a Pseudomonas aeruginosa in Japan., J. Infect. Chemother., 13巻, 4号, pp.276-pp.277, 20070801
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  150. Expressions of virulence factors in Staphylococcus aureus grown in serum, Applied Environmental Microbiology, 20110901
  151. Prevalence of drug-resistant opportunistic microorganisms in oral cavity after oral cancer therapy, Journal of Oral Science, 55巻, 2号, pp.145-pp.155, 20130401
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  156. Expression of IL-1 beta and IL-8 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans, CYTOKINE, 14巻, 3号, pp.152-pp.161, MAY 7 2001
  157. Tn551-mediated insertional inactivation of the fmtB gene encoding a cell wall-associated protein abolishes methicillin resistance in Staphylococcus aureus, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 45巻, 4号, pp.421-pp.431, APR 2000
  158. Modification of autolysis by synthetic peptides derived from the presumptive binding domain of Staphylococcus aureus autolysin, MICROBIOLOGY AND IMMUNOLOGY, 44巻, 6号, pp.463-pp.472, 2000
  159. Identification of a fmtA-like gene that has similarity to other PBPs and beta-lactamases in Staphylococcus aureus, FEMS MICROBIOLOGY LETTERS, 188巻, 1号, pp.35-pp.39, JUL 1 2000
  160. Phage conversion of exfoliative toxin A production in Staphylococcus aureus, MOLECULAR MICROBIOLOGY, 38巻, 4号, pp.694-pp.705, NOV 2000
  161. Acquired subglottic stenosis caused by methicillin resistant Staphylococcus aureus that produce epidermal cell differentiation inhibitor, ARCHIVES OF DISEASE IN CHILDHOOD, 84巻, 1号, pp.F38-pp.F39, JAN 2001
  162. Prevalence of Rho-inactivating epidermal cell differentiation inhibitor toxins in clinical Staphylococcus aureus isolates, JOURNAL OF INFECTIOUS DISEASES, 184巻, 6号, pp.785-pp.788, SEP 15 2001
  163. Identification of six major outer membrane proteins from Actinobacillus actinomycetemcomitans, GENE, 288巻, 1-2号, pp.195-pp.201, APR 17 2002
  164. Suppressed localization of a major autolysin on Staphylococcus aureus treated with tetracycline, JOURNAL OF ELECTRON MICROSCOPY, 50巻, 4号, pp.359-pp.364, 2001
  165. Cloning and sequencing of the gene, fmtC, which affects oxacillin resistance in methicillin-resistant Staphylococcus aureus, FEMS MICROBIOLOGY LETTERS, 203巻, 1号, pp.49-pp.54, SEP 11 2001
  166. Complete nucleotide sequence of a Staphylococcus aureus exfoliative toxin B plasmid and identification of a novel ADP-ribosyltransferase, EDIN-C, INFECTION AND IMMUNITY, 69巻, 12号, pp.7760-pp.7771, DEC 2001
  167. Increased glycan chain length distribution and decreased susceptibility to moenomycin in a vancomycin-resistant Staphylococcus aureus mutant, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 46巻, 1号, pp.75-pp.81, JAN 2002
  168. Clonal association of Staphylococcus aureus causing bullous impetigo and the emergence of new methicillin-resistant clonal groups in Kansai district in Japan, JOURNAL OF INFECTIOUS DISEASES, 185巻, 10号, pp.1511-pp.1516, MAY 15 2002
  169. Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 118巻, 5号, pp.845-pp.850, MAY 2002
  170. Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome, JOURNAL OF CLINICAL INVESTIGATION, 110巻, 1号, pp.53-pp.60, JUL 2002
  171. Isolation and characterization of the dew cluster from the piezophilic deep-sea bacterium Shewanella violacea, JOURNAL OF BIOCHEMISTRY, 132巻, 2号, pp.183-pp.188, AUG 2002
  172. Molecular characterization of an atl null mutant of Staphylococcus aureus, MICROBIOLOGY AND IMMUNOLOGY, 46巻, 9号, pp.601-pp.612, 2002
  173. Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B, INFECTION AND IMMUNITY, 70巻, 10号, pp.5835-pp.5845, OCT 2002
  174. Enhancement of alkaline phosphatase synthesis in pulp cells co-cultured with epithelial cells derived from lower rabbit incisors, CELL BIOLOGY INTERNATIONAL, 27巻, 10号, pp.815-pp.823, 2003
  175. Prevalence of cytolethal distending toxin production in periodontopathogenic bacteria, JOURNAL OF CLINICAL MICROBIOLOGY, 41巻, 4号, pp.1391-pp.1398, APR 2003
  176. Staphylococcus aureus susceptibility to innate antimicrobial peptides, beta-defensins and CAP18, expressed by human keratinocytes, INFECTION AND IMMUNITY, 71巻, 7号, pp.3730-pp.3739, JUL 2003
  177. Moenomycin-resistance is associated with vancomycin-intermediate susceptibility in Staphylococcus aureus, MICROBIOLOGY AND IMMUNOLOGY, 47巻, 12号, pp.927-pp.935, 2003
  178. An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus, JOURNAL OF BIOLOGICAL CHEMISTRY, 278巻, 50号, pp.50671-pp.50681, DEC 12 2003
  179. Macrophage inflammatory protein-3 alpha and beta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 306巻, 4号, pp.867-pp.871, JUL 11 2003
  180. Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans, MOLECULAR MICROBIOLOGY, 50巻, 4号, pp.1125-pp.1139, NOV 2003
  181. Enteropathogenic and enterohaemorrhagic Escherichia coli deliver a novel effector called Cif, which blocks cell cycle G(2)/M transition, MOLECULAR MICROBIOLOGY, 50巻, 5号, pp.1553-pp.1567, DEC 2003
  182. Syntheses of prostaglandin E-2 and E-cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans, INFLAMMATION, 27巻, 6号, pp.341-pp.349, DEC 2003
  183. Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-Cell lines, INFECTION AND IMMUNITY, 72巻, 2号, pp.871-pp.879, FEB 2004
  184. Zymographic characterization of bacteriolytic enzymes produced by oral streptococci, MICROBIOLOGY AND IMMUNOLOGY, 48巻, 6号, pp.465-pp.469, 2004
  185. The gate controlling cell wall synthesis in Staphylococcus aureus, MOLECULAR MICROBIOLOGY, 53巻, 4号, pp.1221-pp.1231, AUG 2004
  186. FtsZ-dependent localization of GroEL protein at possible division sites, GENES TO CELLS, 9巻, 9号, pp.765-pp.771, SEP 2004
  187. Reduced content of lysyl-phosphatidylglycerol in the cytoplasmic membrane affects susceptibility to moenomycin, as well as vancomycin, gentamicin, and antimicrobial peptides, in Staphylococcus aureas, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 48巻, 12号, pp.4800-pp.4807, DEC 2004
  188. Cytolethal distending toxin: A bacterial bullet targeted to nucleus, JOURNAL OF BIOCHEMISTRY, 136巻, 4号, pp.409-pp.413, OCT 2004
  189. Mutation analysis of the histidine residues in the glycylglycine endopeptidase ALE-1, JOURNAL OF BACTERIOLOGY, 187巻, 2号, pp.480-pp.487, JAN 2005
  190. Clinical manifestations of staphylococcal scalded-skin syndrome depend on serotypes of exfoliative toxins, JOURNAL OF CLINICAL MICROBIOLOGY, 43巻, 4号, pp.1890-pp.1893, APR 2005
  191. Innate defences against methicillin-resistant Staphylococcus aureus (MRSA) infection, JOURNAL OF PATHOLOGY, 208巻, 2号, pp.249-pp.260, JAN 2006
  192. New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of beta-defensins, LL37, and TLR2, EUROPEAN JOURNAL OF IMMUNOLOGY, 35巻, 6号, pp.1886-pp.1895, JUN 2005
  193. Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, beta-defensins and LL37, produced by human epithelial cells, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 55巻, 6号, pp.888-pp.896, JUN 2005
  194. Irsogladine maleate influences the response of gap junctional intercellular communication and IL-8 of human gingival epithelial cells following periodontopathogenic bacterial challenge, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 333巻, 2号, pp.502-pp.507, JUL 29 2005
  195. Cloning of swine desmoglein 1 and its direct proteolysis by Staphylococcus hyicus exfoliative toxins isolated from pigs with exudative epidermitis, VETERINARY DERMATOLOGY, 16巻, 5号, pp.315-pp.323, OCT 2005
  196. Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37, JOURNAL OF IMMUNOLOGY, 175巻, 7号, pp.4662-pp.4668, OCT 1 2005
  197. Identification and molecular characterization of an N-acetylmuramyl-L-alanine amidase Sle1 involved in cell separation of Staphylococcus aureus, MOLECULAR MICROBIOLOGY, 58巻, 4号, pp.1087-pp.1101, NOV 2005
  198. Staphylococcus hyicus exfoliative toxins selectively digest porcine desmoglein 1, MICROBIAL PATHOGENESIS, 39巻, 5-6号, pp.171-pp.176, NOV-DEC 2005
  199. Cell wall-targeting domain of glycylglycine endopeptidase distinguishes among peptidoglycan cross-bridges, JOURNAL OF BIOLOGICAL CHEMISTRY, 281巻, 1号, pp.549-pp.558, JAN 6 2006
  200. Identification and molecular characterization of an N-acetylmuraminidase, Aml, involved in Streptococcus mutans cell separation, MICROBIOLOGY AND IMMUNOLOGY, 50巻, 9号, pp.729-pp.742, 2006
  201. Distribution of the exfoliative toxin D gene in clinical Staphylococcus aureus isolates in France, CLINICAL MICROBIOLOGY AND INFECTION, 12巻, 6号, pp.585-pp.588, JUN 2006
  202. Biogenesis of the Actinobacillus actinomycetemcomitans cytolethal distending toxin holotoxin, INFECTION AND IMMUNITY, 74巻, 6号, pp.3480-pp.3487, JUN 2006
  203. Secretory IgA, salivary peroxidase, and catalase-mediated microbicidal activity during hydrogen peroxide catabolism in viridans streptococci: Pathogen coaggregation, JOURNAL OF INFECTIOUS DISEASES, 194巻, 1号, pp.98-pp.107, JUL 1 2006
  204. Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells, INFECTION AND IMMUNITY, 74巻, 9号, pp.5211-pp.5220, SEP 2006
  205. Innate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 146巻, 2号, pp.218-pp.225, NOV 2006
  206. Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of Actinobacillus actinomycetemcomitans, INFECTION AND IMMUNITY, 74巻, 12号, pp.7014-pp.7020, DEC 2006
  207. Molecular characterization of imipenem-resistant Pseudomonas aeruginosa in Hiroshima, Japan, MICROBIOLOGY AND IMMUNOLOGY, 51巻, 3号, pp.271-pp.277, 2007
  208. Efficient elimination of multidrug-resistant Staphylococcus aureus by cloned lysin derived from bacteriophage phi MR11, JOURNAL OF INFECTIOUS DISEASES, 196巻, 8号, pp.1237-pp.1247, OCT 15 2007
  209. Cross-reactive adaptive immune response to oral commensal bacteria results in an induction of receptor activator of nuclear factor-kappa B ligand (RANKL)-dependent periodontal bone resorption in a mouse model, ORAL MICROBIOLOGY AND IMMUNOLOGY, 22巻, 3号, pp.208-pp.215, JUN 2007
  210. Staphylococcal exfoliative toxins: Molecular scissors" of bacteria that attack the cutaneous defense barrier in mammals", JOURNAL OF DERMATOLOGICAL SCIENCE, 49巻, 1号, pp.21-pp.31, JAN 2008
  211. Susceptibility of periodontopathogenic and cariogenic bacteria to Defensins and potential therapeutic use of Defensins in oral diseases, CURRENT PHARMACEUTICAL DESIGN, 13巻, 30号, pp.3084-pp.3095, 2007
  212. CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes, INTERNATIONAL IMMUNOLOGY, 19巻, 9号, pp.1095-pp.1102, SEP 2007
  213. Increased resistance to cationic antimicrobial peptide LL-37 in methicillin-resistant strains of Staphylococcus aureus, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 61巻, 6号, pp.1266-pp.1269, JUN 2008
  214. Cytolethal Distending Toxin Type I and Type IV Genes Are Framed with Lambdoid Prophage Genes in Extraintestinal Pathogenic Escherichia coli, INFECTION AND IMMUNITY, 77巻, 1号, pp.492-pp.500, JAN 2009
  215. Detection of a single bacterial cell using a 16S ribosomal RNA-specific oligonucleotide probe designed to investigate periodontal pathogens, ORAL MICROBIOLOGY AND IMMUNOLOGY, 24巻, 2号, pp.133-pp.140, APR 2009
  216. Increased prevalence and clonal dissemination of multidrug-resistant Pseudomonas aeruginosa with the bla(IMP-1) gene cassette in Hiroshima, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 64巻, 1号, pp.46-pp.51, JUL 2009
  217. Automutanolysin disrupts clinical isolates of cariogenic streptococci in biofilms and planktonic cells, ORAL MICROBIOLOGY AND IMMUNOLOGY, 24巻, 6号, pp.451-pp.455, DEC 2009
  218. Cytolethal Distending Toxin from Aggregatibacter actinomycetemcomitans Induces DNA Damage, S/G(2) Cell Cycle Arrest, and Caspase-Independent Death in a Saccharomyces cerevisiae Model, INFECTION AND IMMUNITY, 78巻, 2号, pp.783-pp.792, FEB 2010
  219. Epidemiology, variable genetic organization and regulation of the EDIN-B toxin in Staphylococcus aureus from bacteraemic patients, MICROBIOLOGY-SGM, 156巻, pp.860-pp.872, MAR 2010
  220. Drug susceptibility and clonality of methicillin-resistant Staphylococcus epidermidis in hospitalized patients with hematological malignancies, IRISH JOURNAL OF MEDICAL SCIENCE, 179巻, 3号, pp.351-pp.356, SEP 2010
  221. Identification of a novel Staphylococcus pseudintermedius exfoliative toxin gene and its prevalence in isolates from canines with pyoderma and healthy dogs, FEMS MICROBIOLOGY LETTERS, 312巻, 2号, pp.169-pp.175, NOV 2010
  222. A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus, JOURNAL OF IMMUNOLOGY, 185巻, 12号, pp.7413-pp.7425, DEC 15 2010
  223. Clonal distribution of enterotoxigenic Staphylococcus aureus on handles of handheld shopping baskets in supermarkets, JOURNAL OF APPLIED MICROBIOLOGY, 110巻, 2号, pp.562-pp.567, FEB 2011
  224. Characterization of Lytic Enzyme Open Reading Frame 9 (ORF9) Derived from Enterococcus faecalis Bacteriophage phi EF24C, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77巻, 2号, pp.580-pp.585, JAN 2011
  225. Regulatory Mechanism for Exfoliative Toxin Production in Staphylococcus aureus, INFECTION AND IMMUNITY, 79巻, 4号, pp.1660-pp.1670, APR 2011
  226. Topical application of Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces cell cycle arrest in the rat gingival epithelium in vivo, JOURNAL OF PERIODONTAL RESEARCH, 46巻, 3号, pp.389-pp.395, JUN 2011
  227. Staphylococcus pseudintermedius exfoliative toxin EXI selectively digests canine desmoglein 1 and causes subcorneal clefts in canine epidermis, VETERINARY DERMATOLOGY, 22巻, 4号, pp.319-pp.326, AUG 2011
  228. Sporadic isolations of a multi-drug resistant Pseudomonas aeruginosa clone during a 14-month epidemic in a general hospital in Hiroshima, INFECTION, 39巻, 3号, pp.247-pp.253, JUN 2011
  229. Expression of Virulence Factors by Staphylococcus aureus Grown in Serum, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77巻, 22号, pp.8097-pp.8105, NOV 2011
  230. A simple method of markerless gene deletion in Staphylococcus aureus, JOURNAL OF MICROBIOLOGICAL METHODS, 87巻, 1号, pp.76-pp.81, OCT 2011
  231. The Listeria monocytogenes serotype 4b autolysin IspC has N-acetylglucosaminidase activity, GLYCOBIOLOGY, 22巻, 10号, pp.1311-pp.1320, OCT 2012
  232. Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice, JOURNAL OF DERMATOLOGICAL SCIENCE, 70巻, 1号, pp.12-pp.18, APR 2013
  233. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice, JOURNAL OF GASTROENTEROLOGY, 48巻, 11号, pp.1259-pp.1270, NOV 2013
  234. Emergence of Staphylococcus aureus Carrying Multiple Drug Resistance Genes on a Plasmid Encoding Exfoliative Toxin B, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57巻, 12号, pp.6131-pp.6140, DEC 2013
  235. Bacteriocin Protein BacL(1) of Enterococcus faecalis Is a Peptidoglycan D-Isoglutamyl-L-lysine Endopeptidase, JOURNAL OF BIOLOGICAL CHEMISTRY, 288巻, 52号, pp.36915-pp.36925, DEC 27 2013
  236. Comprehensive Analysis of Systemically Disseminated ST8/non-USA300 type Community-acquired Methicillin-resistant Staphylococcus aureus Infection, INTERNAL MEDICINE, 53巻, 8号, pp.907-pp.912, 2014
  237. Phospholipase C-Related Catalytically Inactive Protein Participates in the Autophagic Elimination of Staphylococcus aureus Infecting Mouse Embryonic Fibroblasts, PLOS ONE, 9巻, 5号, MAY 27 2014
  238. Application of moisturizer to neonates prevents development of atopic dermatitis, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 134巻, 4号, pp.824-pp.U414, OCT 2014
  239. Complete Nucleotide Sequence of the IncN Plasmid Encoding IMP-6 and CTX-M-2 from Emerging Carbapenem-Resistant Enterobacteriaceae in Japan, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 59巻, 2号, pp.1356-pp.1359, FEB 2015
  240. Prevalence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer, JOURNAL OF ORAL SCIENCE, 55巻, 2号, pp.145-pp.155, JUN 2013
  241. Persistence and Epidemic Propagation of a Pseudomonas aeruginosa Sequence Type 235 Clone Harboring an IS26 Composite Transposon Carrying the bla(IMP-1) Integron in Hiroshima, Japan, 2005 to 2012, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 59巻, 5号, pp.2678-pp.2687, MAY 2015
  242. Identification and Characterization of a Novel Staphylococcal Emetic Toxin, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 81巻, 20号, pp.7034-pp.7040, OCT 2015
  243. Positive Regulation of Staphylococcal Enterotoxin H by Rot (Repressor of Toxin) Protein and Its Importance in Clonal Complex 81 Subtype 1 Lineage-Related Food Poisoning, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 81巻, 22号, pp.7782-pp.7790, NOV 2015
  244. Tripoli metallo-β-lactamase-1 (TMB-1)-producing Acinetobacter spp. with decreased resistance to imipenem in Japan., ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58巻, 4号, pp.2477-pp.2477, 7-14
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受賞

  1. 1994年, 日本細菌学会黒谷奨励賞

社会活動

委員会等委員歴

  1. 医道審議会専門委員, 2012年02月, 2014年02月, 厚生労働省
  2. 広島県医療審議会委員, 2013年03月, 2015年03月, 広島県
  3. 広島県感染症・疾病管理センター感染症専門員, 2013年04月, 2015年03月, 広島県
  4. 広島県感染症・疾病管理センター検討委員会委員, 2011年11月, 2013年11月, 広島県
  5. 広島県歯科衛生連絡協議会副会長, 2013年04月, 2015年03月, 広島県歯科衛生連絡協議会
  6. 歯科医師試験委員, 2011年05月, 2013年05月, 厚生労働省医政局医事課
  7. 非常勤講師, 2013年04月, 2014年03月, IGL医療専門学校
  8. 非常勤講師, 2013年04月, 2014年03月, 愛媛大学医学部
  9. 非常勤講師, 2013年10月, 2014年03月, 高知大学
  10. 非常勤講師, 2013年07月, 2013年09月, 長崎大学歯学部
  11. 非常勤講師, 2013年04月, 2014年03月, 徳島大学
  12. 副会長, 2013年04月, 2015年03月, 広島市歯科衛生連絡協議会
  13. 非常勤講師, 2014年04月, 2015年03月, 徳島大学
  14. 非常勤講師, 2014年04月, 2014年09月, 長崎大学歯学部
  15. 非常勤講師, 2014年04月, 2015年03月, IGL医療専門学校
  16. 広島県歯科保健文化賞審査委員, 2014年07月, 2014年11月, 広島県歯科衛生連絡協議会
  17. 非常勤講師, 2014年10月, 2015年03月, 高知大学
  18. 非常勤講師, 2015年04月, 2016年03月, 岡山大学大学院医歯薬学総合研究科
  19. 広島県感染症・疾病管理センター感染症専門員, 2015年04月, 2016年03月, 広島県
  20. 非常勤講師, 2015年04月, 2016年03月, 徳島大学
  21. 非常勤講師, 2015年04月, 2016年03月, IGL医療福祉専門学校
  22. 副会長, 2015年04月, 2017年03月, 広島市歯科衛生連絡協議会
  23. 非常勤講師, 2015年04月, 2015年09月, 群馬大学
  24. 非常勤講師, 2015年04月, 2015年09月, 長崎大学歯学部
  25. 広島県歯科衛生連絡協議会副会長, 2015年04月, 2017年03月, 広島県歯科衛生連絡協議会
  26. 広島県歯科衛生連絡協議会副会長, 広島県歯科衛生連絡協議会