Last Updated :2021/04/06

Affiliations, Positions
Translational Research Center, Professor, Collaborative Research Laboratory

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Pathological medical chemistry
  • Medicine,dentistry, and pharmacy;Basic medicine;Human genetics
  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Respiratory organ internal medicine

Research Keywords

  • Integrin
  • Osteopontin
  • Extracellular matrix
  • Transglutaminase
  • Antibody
  • Polymorphism
  • Tissue fibrosis
  • Neutrophil chemotaxis

Research Activities

Academic Papers

  1. Fibronectin extra domain a promotes liver sinusoid repair following hepatectomy, PLoS ONE, 11(10), e0163737, 20161014
  2. OPN-a induces muscle inflammation by increasing recruitment and activation of pro-inflammatory macrophages, Exp Physiol, 101, 1285-1300, 20160725
  3. Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice, BIOLOGY OPEN, 5(8), 1142-1148, 20160815
  4. α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism., eLife, 5, e13063, 20160419
  5. Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction, J Gastroenterol, 51, 1161-1174, 20160404
  6. ★, Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits, Sci Rep, 5, 13756, 20150909
  7. Role of Integrin-α8 in Bleomycin-Induced Lung Injury, Annals of American Thoracic Sciety, 12, S74-S74, 201503
  8. Deletion of Tetraspanin CD9 Diminishes Lymphangiogenesis in Vivo and in Vitro, J Biol Chem, 288(4), 2118-2131, 201300
  9. ★, Osteopontin Undergoes Polymerization in Vivo and Gains Chemotactic Activity for Neutrophils Mediated by Integrin α9β1, J Biol Chem, 286(13), 11170-11178, 201100
  10. Osteopontin is a tumor autoantigen in prostate cancer patients, Oncol Lett, 2(1), 109-114, 201100
  11. ★, Polymeric Osteopontin Employs Integrin α9β1 as a Receptor and Attracts Neutrophils by Presenting a de Novo Binding Site, J Biol Chem, 284(22), 14769-14776, 200900
  12. Gene-environment association of an ITGB2 sequence variant with obesity in ethnic Japanese, Obesity, 16(6), 1463-1466, 200806
  13. Enhanced biological activity of polymeric osteopontin., FEBS Lett, 581(14), 2697-2701, 200707
  14. The integrin alpha 5 beta 1 regulates chondrocyte hypertrophic differentiation induced by GTP-bound transglutaminase 2, Matrix Biol, 26(6), 409-418, 200700
  15. Distinct structural requirements for binding of the integrins αvβ6, αvβ3,αvβ5, α5β1 and α9β1 to osteopontin, Matrix Biol, 24(6), 418-427, 200509
  16. Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences., J. Cell. Biochem., 84, 420-432, 200204
  17. Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structual requirements for interaction of the integrin α9β1 with VCAM-1, tenascin-C and osteopontin., J Biol Chem, 275, 31930-31937, 200104
  18. Tissue transglutaminase, coagulation factor XIII and the pro-polypeptide of von Willebrand factor are all ligands for the integrins α9β1 and α4β1., J Biol Chem, 275, 23589-23595, 200104
  19. The cytoplasmic domain of the integrin α9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner., Mol Biol Cell, 12, 3214-3225, 200104
  20. The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma., British J Cancer, 82, 1211-1217, 200104
  21. p53 gene mutations are associated with shortened survival in patients with advanced non-small-cell lung cancer. -An analysis of medically managed patients-., Clin Cancer Res, 6, 526-530, 200104
  22. ets-1expression in extrahepatic bile duct carcinoma and cholangiocellular carcinoma., Oncology, 58, 248-252, 200104
  23. Mapping of the cryptic integrin-binding site in osteopontin suggests a new mechanism by which thrombin can regulate inflammation and tissue repair., Trend Cardiovasc Med, 10, 155-159, 200104
  24. Significance of α9β1 and αvβ6 Integrin Expression in Breast Carcinoma, Breast Cancer, 7(1), 19-26, 200101
  25. ★, The integrin α9β1 binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino terminal fragment of osteopontin., J Biol Chem, 274, 36328-36334, 199904
  26. ★, Identification of the ligand binding site for the integrin α9β1 in the third fibronectin type III repeat of tenascin-C., J Biol Chem, 273, 11423-11428, 199904
  27. Specific α9β1-integrin-mediated gene transfer by a synthetic peptide., FEBS Letters, 458, 329-332, 199904
  28. A novel peptide, PLAEIDGIELTY, for the targeting of α9β1-integrins., FEBS Letters, 429, 269-273, 199904
  29. Roles of airway epithelial integrins in health and disease., Chest, 109, 29S-32S, 199604
  30. Differential effects of the integrins α9β1, αvβ3, and αvβ6 on cell proliferative responses to tenascin. Roles of the β subunit extracellular and cytoplasmic domains., J Biol Chem, 271, 24144-24150, 199604
  31. Differential regulation of airway epithelial integrins by growth factors., Am J Respir Cell Mol Biol, 15, 664-672, 199604
  32. Chronic exposure to cigarette smoke inhibits the stimulating effects of mineral fibers on the production of tumor necrosis factor by alveolar macrophages of rats., Int J Occup Environ Health, 2, 95-98, 199604
  33. Comparison of alveolar septal inflammation to bronchoalveolar lavage in interstitial lung diseases., Respiration, 63, 94-99, 199604
  34. ★, Integrin α9β1 mediates cell attachement to the third fibronectin type III repeat in tenascin, J Biol Chem, 269, 26691-26696, 199504
  35. Synergistic effects of mineral fibres and cigarette smoke on the production of tumor necrosis factor by alveolar macrophages of rats., Br J Ind Med, 50, 955-960, 199504
  36. Integrin receptors for extracellular matrix with special reference to tenascin., Trends Glycosci Glycotech, 7, 417-427, 199504
  37. Hypoglycemia associated with localized fibrous mesothelioma., J UOEH, 17, 191-197, 199504
  38. Effects of inhaled ceramic fibres on macrophage function of rat lungs., Occup Environment Med, 51, 62-67, 199504
  39. Cellular changes induced in rat lungs by inhalation of ceramic fibers, Toxicol Indust Health, 7, 479-484, 199104

Publications such as books

  1. 1993, Health Risks From Exposure to Mineral Fibres: An International Perspective. , Captus University Publications, 1993, Scholarly Book, Joint work, 380
  2. 1998, Identification of the ligand binding site for the integrin α9β1 in the third fibronectin type III repeat of tenascin-C, 4th CGGH symposium-Frontiers in Matrix Biology, 1998, 07, Report
  3. 2016/02, Transglutaminases -Multiple Functional Modifiers and Targets for New Drug Discovery-, Springer, 2016, 2, Scholarly Book, Single work, English, Yokosaki, Y., 978-4-431-55825-5, 391, 129-151, A New Integrin-Binding Site on a Transglutaminase-Catalyzed Polymer