YASUYUKI YOKOSAKI

Last Updated :2021/04/06

Affiliations, Positions
Translational Research Center, Professor, Collaborative Research Laboratory
E-mail
yokosakihiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Pathological medical chemistry
  • Medicine,dentistry, and pharmacy;Basic medicine;Human genetics
  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Respiratory organ internal medicine

Research Keywords

  • Integrin
  • Osteopontin
  • Extracellular matrix
  • Transglutaminase
  • Antibody
  • Polymorphism
  • Tissue fibrosis
  • Neutrophil chemotaxis

Research Activities

Academic Papers

  1. Fibronectin extra domain a promotes liver sinusoid repair following hepatectomy, PLoS ONE, 11(10), e0163737, 20161014
    Link to Paper Search Results by DOI
  2. OPN-a induces muscle inflammation by increasing recruitment and activation of pro-inflammatory macrophages, Exp Physiol, 101, 1285-1300, 20160725
  3. Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice, BIOLOGY OPEN, 5(8), 1142-1148, 20160815
    Link to Paper Search Results by DOI
  4. α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism., eLife, 5, e13063, 20160419
    Link to Paper Search Results by DOI
  5. Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction, J Gastroenterol, 51, 1161-1174, 20160404
  6. ★, Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits, Sci Rep, 5, 13756, 20150909
    Link to Paper Search Results by DOI
  7. Role of Integrin-α8 in Bleomycin-Induced Lung Injury, Annals of American Thoracic Sciety, 12, S74-S74, 201503
    Link to Paper Search Results by DOI
  8. Deletion of Tetraspanin CD9 Diminishes Lymphangiogenesis in Vivo and in Vitro, J Biol Chem, 288(4), 2118-2131, 201300
  9. ★, Osteopontin Undergoes Polymerization in Vivo and Gains Chemotactic Activity for Neutrophils Mediated by Integrin α9β1, J Biol Chem, 286(13), 11170-11178, 201100
  10. Osteopontin is a tumor autoantigen in prostate cancer patients, Oncol Lett, 2(1), 109-114, 201100
  11. ★, Polymeric Osteopontin Employs Integrin α9β1 as a Receptor and Attracts Neutrophils by Presenting a de Novo Binding Site, J Biol Chem, 284(22), 14769-14776, 200900
  12. Gene-environment association of an ITGB2 sequence variant with obesity in ethnic Japanese, Obesity, 16(6), 1463-1466, 200806
    Link to Paper Search Results by DOI
  13. Enhanced biological activity of polymeric osteopontin., FEBS Lett, 581(14), 2697-2701, 200707
  14. The integrin alpha 5 beta 1 regulates chondrocyte hypertrophic differentiation induced by GTP-bound transglutaminase 2, Matrix Biol, 26(6), 409-418, 200700
  15. Distinct structural requirements for binding of the integrins αvβ6, αvβ3,αvβ5, α5β1 and α9β1 to osteopontin, Matrix Biol, 24(6), 418-427, 200509
    Link to Paper Search Results by DOI
  16. Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences., J. Cell. Biochem., 84, 420-432, 200204
  17. Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structual requirements for interaction of the integrin α9β1 with VCAM-1, tenascin-C and osteopontin., J Biol Chem, 275, 31930-31937, 200104
  18. Tissue transglutaminase, coagulation factor XIII and the pro-polypeptide of von Willebrand factor are all ligands for the integrins α9β1 and α4β1., J Biol Chem, 275, 23589-23595, 200104
  19. The cytoplasmic domain of the integrin α9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner., Mol Biol Cell, 12, 3214-3225, 200104
  20. The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma., British J Cancer, 82, 1211-1217, 200104
  21. p53 gene mutations are associated with shortened survival in patients with advanced non-small-cell lung cancer. -An analysis of medically managed patients-., Clin Cancer Res, 6, 526-530, 200104
  22. ets-1expression in extrahepatic bile duct carcinoma and cholangiocellular carcinoma., Oncology, 58, 248-252, 200104
  23. Mapping of the cryptic integrin-binding site in osteopontin suggests a new mechanism by which thrombin can regulate inflammation and tissue repair., Trend Cardiovasc Med, 10, 155-159, 200104
  24. Significance of α9β1 and αvβ6 Integrin Expression in Breast Carcinoma, Breast Cancer, 7(1), 19-26, 200101
  25. ★, The integrin α9β1 binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino terminal fragment of osteopontin., J Biol Chem, 274, 36328-36334, 199904
  26. ★, Identification of the ligand binding site for the integrin α9β1 in the third fibronectin type III repeat of tenascin-C., J Biol Chem, 273, 11423-11428, 199904
  27. Specific α9β1-integrin-mediated gene transfer by a synthetic peptide., FEBS Letters, 458, 329-332, 199904
  28. A novel peptide, PLAEIDGIELTY, for the targeting of α9β1-integrins., FEBS Letters, 429, 269-273, 199904
  29. Roles of airway epithelial integrins in health and disease., Chest, 109, 29S-32S, 199604
  30. Differential effects of the integrins α9β1, αvβ3, and αvβ6 on cell proliferative responses to tenascin. Roles of the β subunit extracellular and cytoplasmic domains., J Biol Chem, 271, 24144-24150, 199604
  31. Differential regulation of airway epithelial integrins by growth factors., Am J Respir Cell Mol Biol, 15, 664-672, 199604
  32. Chronic exposure to cigarette smoke inhibits the stimulating effects of mineral fibers on the production of tumor necrosis factor by alveolar macrophages of rats., Int J Occup Environ Health, 2, 95-98, 199604
  33. Comparison of alveolar septal inflammation to bronchoalveolar lavage in interstitial lung diseases., Respiration, 63, 94-99, 199604
  34. ★, Integrin α9β1 mediates cell attachement to the third fibronectin type III repeat in tenascin, J Biol Chem, 269, 26691-26696, 199504
  35. Synergistic effects of mineral fibres and cigarette smoke on the production of tumor necrosis factor by alveolar macrophages of rats., Br J Ind Med, 50, 955-960, 199504
  36. Integrin receptors for extracellular matrix with special reference to tenascin., Trends Glycosci Glycotech, 7, 417-427, 199504
  37. Hypoglycemia associated with localized fibrous mesothelioma., J UOEH, 17, 191-197, 199504
  38. Effects of inhaled ceramic fibres on macrophage function of rat lungs., Occup Environment Med, 51, 62-67, 199504
  39. Cellular changes induced in rat lungs by inhalation of ceramic fibers, Toxicol Indust Health, 7, 479-484, 199104

Publications such as books

  1. 1993, Health Risks From Exposure to Mineral Fibres: An International Perspective. , Captus University Publications, 1993, Scholarly Book, Joint work, 380
  2. 1998, Identification of the ligand binding site for the integrin α9β1 in the third fibronectin type III repeat of tenascin-C, 4th CGGH symposium-Frontiers in Matrix Biology, 1998, 07, Report
  3. 2016/02, Transglutaminases -Multiple Functional Modifiers and Targets for New Drug Discovery-, Springer, 2016, 2, Scholarly Book, Single work, English, Yokosaki, Y., 978-4-431-55825-5, 391, 129-151, A New Integrin-Binding Site on a Transglutaminase-Catalyzed Polymer