KOUSUKE ODA

Last Updated :2023/02/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Assistant Professor
E-mail
kosuke-81hiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2008/12/01, 2010/03/31, Institute of Physical and Chemical Research, trainee
  • 2009/05/01, 2010/04/30, Hiroshima University, Graduate School of Biomedical Sciences, Research Associate
  • 2010/04/01, 2013/03/31, Institute of Physical and Chemical Research, Visiting Researcher
  • 2010/05/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
  • 2012/05/01, 2014/12/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor (Special Appointment)
  • 2015/01/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor

Educational Backgrounds

  • Kyoto Pharmaceutical University, Faculty of Pharmaceutical Science, Japan, 2001/04, 2005/03
  • Hiroshima university, 2005/04, 2007/03
  • Hiroshima University, Graduate School of Biomedical Sciences, Japan, 2007/04, 2010/03

Academic Degrees

  • Hiroshima University
  • Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Virology
  • Biology;Biological Science;Structural biochemistry

Research Keywords

  • Paramyxovirus
  • Structural biochemistry
  • Accessory protein
  • Drug discovery

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Year, Biological Responses

Research Activities

Academic Papers

  1. A novel transformation system using a bleomycin resistance marker with chemosensitizers for Aspergillus oryzae, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 383(1), 42-47, 20090522
  2. ★, Catalytic Mechanism of Bleomycin N-Acetyltransferase Proposed on the Basis of Its Crystal Structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(2), 1446-1456, 20100108
  3. Molecular Cloning and Heterologous Expression of a Biosynthetic Gene Cluster for the Antitubercular Agent D-Cycloserine Produced by Streptomyces lavendulae, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(3), 1132-1139, 20100119
  4. A Molecular Mechanism for Copper Transportation to Tyrosinase That Is Assisted by a Metallochaperone, Caddie Protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(34), 30219-30231, 20110826
  5. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 79(10), 2999-3005, 20110802
  6. Heme Protein and Hydroxyarginase Necessary for Biosynthesis of D-Cycloserine, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(7), 3682-3689, 20120430
  7. Establishment of an In Vitro D-Cycloserine-Synthesizing System by Using O-Ureido-L-Serine Synthase and D-Cycloserine Synthetase Found in the Biosynthetic Pathway, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(6), 2603-2612, 20130525
  8. ★, Crystallographic Study To Determine the Substrate Specificity of an L-Serine-Acetylating Enzyme Found in the D-Cycloserine Biosynthetic Pathway, JOURNAL OF BACTERIOLOGY, 195(8), 1741-1749, 20130208
  9. An alternative allosteric regulation mechanism of an acidophilic L-lactate dehydrogenase from Enterococcus mundtii 15-1A, FEBS OPEN BIO, 4, 834-847, 20140706
  10. ★, Carotenoid-Producing Lactobacillus plantarum Is Resistant to gamma-Ray Irratidation., KURRI progress report 2012, 255-255, 2013
  11. ★, The structural and mutational analyses of O-ureido-l-serine synthase necessary for d-cycloserine biosynthesis, FEBS JOURNAL, 282(20), 3929-3944, 20150721
  12. ★, Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein, JOURNAL OF VIROLOGY, 89(22), 11487-11499, 20151122
  13. Inactivation of influenza virus by a supplemental fermented plant product ('Manda Koso'), Hiroshima Journal of Medical Sciences, 66, 97-101, 20170907
  14. ★, Structural analysis of the STAT1:STAT2 heterodimer revealed the mechanism of Sendai virus C protein-mediated blockade of type 1 interferon signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 292(48), 19752-19766, 20171201
  15. ★, Structural insights into STAT1 dependent inhibition of STAT2 phosphorylation by Sendai virus C protein., IUMS2017, XVII International Congress of Virology, 36, 2017
  16. Eligibility of Feline Calicivirus for a Surrogate of Human Norovirus in Comparison with Murine Norovirus, Poliovirus and Coxsackievirus, BIOCONTROL SCIENCE, 23(3), 145-149, 201809
  17. Effects of traditional Kampo drugs and their constituent crude drugs on influenza virus replication in vitro: suppression of viral protein synthesis by Glycyrrhizae radix, Evidence-Based Complementary and Alternative Medicine, 20191203
  18. ★, Crystal structure of an Nomega-hydroxy-L-arginine hydrolase found in the D-cycloserine biosynthetic pathway., Acta Crystallographica Section D STRUCTURAL BIOLOGY, 76(6), 506-514, 20200601
  19. Catalytic specificity of the Lactobacillus plantarum cystathionine gamma-lyase presumed by the crystallographic analysis., Scientific Reports, 10(1), 14886, 20200910
  20. ★, Significance of the association of the C protein with Alix for the budding of Sendai virus on the basis of the crystal structure, IUMS2020, XVIII International Congress of Virology, VIR-DW10-3, 2020
  21. The basicity of an active-site water molecule discriminates between tyrosinase and catechol oxidase activity, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 183, 1861-1870, 20210731
  22. Lectins engineered to favor a glycan-binding conformation have enhanced antiviral activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 296, 2021
  23. ★, Structural Insight into the Interaction of Sendai Virus C Protein with Alix To Stimulate Viral Budding, JOURNAL OF VIROLOGY, 95(19), 20210909
  24. Ethanol Susceptibility of SARS-CoV-2 and Other Enveloped Viruses, BIOCONTROL SCIENCE, 26(3), 177-180, 2021
  25. ★, Crystal structure of O-ureidoserine racemase found in the D-cycloserine biosynthetic pathway, Proteins, 90(4), 912-918, 20220405
  26. ★, Catalytic Mechanism of DcsB: Arginase Framework Used for Hydrolyzing Its Inhibitor, Protein Science, 31(6), e4338, 20220601
  27. ★, Similar but different catalytic mechanism of Nomega-hydroxy-L-arginine hydrolase: arginase framework used for hydrolyzing its inhibitor, The 36th Annual Symposium of The Protein Society, 2022

Invited Lecture, Oral Presentation, Poster Presentation

  1. Studies on self-protection mechanisms in antibiotic-producing organisms, Kosuke Oda, 2011/09/19, With Invitation, Japanese
  2. Development of high-throughput screening to find an anti-human parainfluenza virus drug targeting C protein., Kosuke Oda, Takayoshi Okabe, Yasuyuki Matoba, Takashi Irie, Takemasa Sakaguchi, 2017/10/24, Without Invitation, English
  3. IFN受容体を介したセンダイウイルスCタンパク質によるIFNシグナル伝達阻害機構の解明, 7th Negative Strand Virus-Japan Symposium, 2018/01/17, Without Invitation, Japanese
  4. Relationship between the inducibility of the IFN-β production in Sendai virus Cantell strain and the antagonistic action toward the IFN-α/β signal transduction by the C protein., Kosuke Oda, 2018/01/23, Without Invitation, Japanese
  5. Molecular mechanism of paramyxovirus pathogenesis mediated by the accessory C protein, Kosuke Oda, Yasuyuki Matoba, Takashi Irie, Takemasa Sakaguchi., 2018/06/26, Without Invitation, Japanese, Niigata
  6. Inhibition of the IFN-α-inducible phosphorylation of Tyk2/Jak1 by Sendai virus C protein., Kosuke Oda, Takemasa Sakaguchi, 2018/10/28, Without Invitation, English
  7. Virus-particle budding is facilitated by Sendai virus C protein in an ESCRT-independent manner, Kosuke Oda, Yasuyuki Matoba, Takashi Irie, Takemasa Sakaguchi, 2019 International Conference On Biology and Medical Sciences (ICBMS2019), 2019/02/28, With Invitation, English, Asia Pacific Society for Biology and Medical Sciences, Tiruru (Okinawa)
  8. Enzymatic and Crystallographic Studies of DcsA and DcsB Responsible for Supplying Hydroxyurea from L-Arginine in the D-Cycloserine Biosynthetic Pathway, Kosuke Oda, Yasuyuki Matoba., International Symposium on Diffraction Structure Biology 2019, 2019/10/17, Without Invitation, English
  9. Antivirus drug screening targeting for Paramyxovirus C protein, Kosuke Oda, Toshihito Nomura, Kiyohito Kihira, Takayoshi Okabe, Akifumi Higashiura, Yasuyuki Matoba, Takemasa Sakaguchi, 2019/10/29, Without Invitation, English
  10. Significance of the association of the C protein with Alix for the budding of Sendai virus on the basis of the crystal structure, Oda, K., Matoba, Y., Sugiyama, Y., Sakaguchi, T., IUMS2020, XVIII International Congress of Virology, 2020/11/16, Without Invitation, English, Korea
  11. Similar but different catalytic mechanism of Nomega-hydroxy-L-arginine hydrolase: arginase framework used for hydrolyzing its inhibitor, Oda, K., Matoba, Y., The 36th Annual Symposium of The Protein Society, 2022/07/07, Without Invitation, English
  12. Catalytic Mechanism of DcsB: Arginase Framework Used for Hydrolyzing Its Inhibitor, Oda, K., Matoba, Y, IUMS2022, 2022/07/20, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. 2010/08, 2011/03
  2. KAKENHI, 2012, 2014
  3. KAKENHI, 2013, 2014
  4. 2014, 2014
  5. 2014, 2016
  6. 2014, 2016
  7. KAKENHI, 2015, 2016
  8. KAKENHI, 2016, 2017
  9. 2016, 2016
  10. 2017, 2017
  11. 2017, 2017
  12. 2018, 2021
  13. 2019, 2019
  14. KAKENHI, 2020, 2022

Social Activities

History as Peer Reviews of Academic Papers

  1. 2021, Microbiology and Immunology, Others, 1
  2. 2022, Scientific Reports, Others, 1