MASATAKA TSUDA

Last Updated :2021/07/13

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
Web Site
E-mail
tsudamhiroshima-u.ac.jp
Other Contact Details
1-3-1,Kagamiyama,Higashi-Hiroshima, Japan, Japan
TEL : (+81)82-424-7458 FAX : (+81)
Self-introduction
Research interest is the mechanism of DNA repair

Basic Information

Major Professional Backgrounds

  • 2014/04, 2018/01, Kyoto University, Graduate School of Medicine, Program-Specific Assistant Professor
  • 2018/02/01, 2019/03/31, Hiroshima University, Graduate School of Science, Assistant Professor

Academic Degrees

  • Kyoto University
  • Nagahama Institute of Bio-Science and Technology

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Biology;Basic biology;Genetics / Chromosome dynamics

Research Keywords

  • DNA repair
  • DNA damage
  • Radiation

Affiliated Academic Societies

  • The Molecular Biology Society of Japan
  • The Japanese Radiation Research Society
  • The Japanese Environmental Mutagen Society

Educational Activity

Course in Charge

  1. 2021, Liberal Arts Education Program1, 2Term, Science and Radiation
  2. 2021, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  3. 2021, Undergraduate Education, 1Term, Seminar on Biological Science
  4. 2021, Undergraduate Education, 2Term, Advanced Biology
  5. 2021, Undergraduate Education, 3Term, Biochemistry A
  6. 2021, Undergraduate Education, Second Semester, Seminar for Gene Chemistry
  7. 2021, Undergraduate Education, First Semester, Special Study for Graduation
  8. 2021, Undergraduate Education, Second Semester, Special Study for Graduation
  9. 2021, Undergraduate Education, First Semester, Practice for Fundamental Biology I
  10. 2021, Undergraduate Education, First Semester, Practice for Fundamental Biology III
  11. 2021, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  12. 2021, Graduate Education (Master's Program) , 1Term, Introduction to Life Science
  13. 2021, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Mathematical and Life Sciences
  14. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Life Science A
  15. 2021, Graduate Education (Master's Program) , 2Term, Exercises in Life Science A
  16. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Life Science B
  17. 2021, Graduate Education (Master's Program) , 4Term, Exercises in Life Science B
  18. 2021, Graduate Education (Master's Program) , 4Term, Gene Chemistry A
  19. 2021, Graduate Education (Master's Program) , 2Term, Topical Seminar in Life Science A
  20. 2021, Graduate Education (Master's Program) , 4Term, Topical Seminar in Life Science B
  21. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  22. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  23. 2021, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
  24. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  25. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  26. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E
  27. 2021, Graduate Education (Master's Program) , 2Term, Basics and Practical Applications of Genome Editing

Research Activities

Academic Papers

  1. FANCD2-associated nuclease 1 partially compensates for the lack of Exonuclease 1 in mismatch repair, Mol Cell Biol.
  2. Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage, PLoS One, 16(6), e0252587, Jun 1
  3. ★, Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3 '-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1), DNA REPAIR, 91-92, 2020
  4. Direct observation of damage clustering in irradiated DNA with atomic force microscopy, Nucleic Acids Res., 2020
  5. Estrogen induces mammary ductal dysplasia via upregulation of Myc expression in a DNA-repair-deficient condition., iScience., 2020
  6. Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 39(1-3), 170-184, 20200220
  7. Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells, PLOS ONE, 15(6), 20200626
  8. Repair mechanisms for topoisomerase covalently trapped on DNA, 52(9), 53-56, 2020
  9. PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching, PLOS ONE, 14(3), 20190306
  10. Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase eta, SCIENTIFIC REPORTS, 9, 20190926
  11. Type II DNA Topoisomerase cause spontaneous double-strand breaks in genomic DNA., Genes (Basel)., 2019
  12. SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines., Proc Natl Acad Sci U S A., 115(50), 12793-12798, 2018
  13. ★, BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes, Proc Natl Acad Sci U S A., 115(45), E10642-E10651, 20181106
  14. ALC1/CHD1L, chromatin-remodeling enzyme, is required for efficient base excision repair., PLoS One., 12(11), e0188320, 2017
  15. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts., Nucleic Acids Res., 45(17), 10079-10088, 2017
  16. Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells., PLoS One., 12(9), e0185141, 2017
  17. ★, The Dominant Role of Proofreading Exonuclease Activity of Replicative Polymerase e in Cellular Tolerance to Cytarabine (Ara-C)., Oncotarget., 8(20), 33457-33474, 2017
  18. Mre11 is essential for the removal of lethal topoisomerase 2 covalent cleavage complexes., Mol Cell, 64(3), 580-592, 2016
  19. Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides., Cell Cycle., 15(15), 1997-2008, 2016
  20. In vivo evidence for translesion synthesis by the replicative DNA polymerase delta., Nucleic Acids Res., 44(15), 7242-7250, 2016
  21. The POLD3 subunit of DNA polymerase d can promote translesion synthesis independently of DNA polymerase z, Nucleic Acids Res., 43(3), 1671-1683, 2015
  22. SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss., Genes Cells., 19(10), 743-754, 2014
  23. ★, Novel pathway of centrosome amplification that does not require DNA lesions., Cancer Sci., 103(2), 191-196, 2012
  24. Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway., Proc Natl Acad Sci U S A., 108(16), 6492-6496, 2011
  25. XRCC1 prevents toxic PARP1 trapping during DNA base excision repair, Mol Cell., in press
  26. Restoration of ligatable clean double-strand break ends is the rate-limiting step in the rejoining of ionizing-radiation-induced DNA breakage., DNA Repair, in press
  27. Genetic Evidence for the Involvement of Mismatch Repair Proteins, PMS2 and MLH3, in a Late Step of Homologous Recombination, J Biol Chem ., in press
  28. In Vivo Level of Poly(ADP-ribose), Challenges, 9(1), 20180410

Awards

  1. 2015, ICRR2015 Excellent Poster Award, ICRR, PDIP38 is required for efficient translesion DNA synthesis by DNA polymerase eta and zeta

External Funds

Acceptance Results of Competitive Funds

  1. 2020, 2022
  2. 2021, 2023
  3. 2021, 2022
  4. 2020, 2022
  5. 2020
  6. 2020, 2022
  7. 2020, 2021
  8. 2020, 2022
  9. Japan Society for the Promotion of Science, 2018, 2019
  10. 2019