ATSUSHI SAITO

Last Updated :2024/02/26

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor
E-mail
saitoahiroshima-u.ac.jp
Self-introduction
I am working on functional analysis of the endoplasmic reticulum, an intracellular organelle, and elucidating its relationship with diseases.

Basic Information

Academic Degrees

  • Nara Institute of Science and Technology
  • Miyazaki University

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry

Research Keywords

  • organelle-communication
  • endoplasmic reticulum

Affiliated Academic Societies

  • The Biomedical Society for Stress response, Japan
  • The Japanese Cancer Association
  • The Japanese Society for Neurochemistry
  • The Japanese Society for Neurochemistry
  • The Japanese Biochemical Society Secretariat
  • The Japanese Association of Anatomists
  • Society for Neuroscience

Educational Activity

Course in Charge

  1. 2023, Undergraduate Education, Year, Physiology and Biochemistry
  2. 2023, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry

Research Activities

Academic Papers

  1. p53-independent tumor suppression by cell cycle arrest via CREB/ATF transcription factor OASIS, Cell Reports, 42, 20230530
  2. Impact of Nuclear Envelope Stress on Physiological and Pathological Processes in Central Nervous System, NEUROCHEMICAL RESEARCH, 47(9), 2478-2487, 202209
  3. OASIS/CREB3L1 is a factor that responds to nuclear envelope stress, CELL DEATH DISCOVERY, 7(1), 20210629
  4. Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells, BRAIN RESEARCH, 1749, 20201215
  5. Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its beta 1 subunit, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 521(4), 1030-1035, 20200122
  6. Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation., Scientific Reports, 9(1), 20301, 20191230
  7. Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(2), 436-442, 20190625
  8. Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(1), 217-223, 20190618
  9. NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells, Journal of Biological Chemistry, 294(1), 101-105, 20190104
  10. Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria, and Plasma Membrane, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 20181018
  11. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, CELL DEATH & DISEASE, 9(808), 20180724
  12. Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury, NEUROSCIENCE, 375, 34-48, 20180401
  13. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183, PLOS ONE, 13(1), 20180104
  14. The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression, SCIENTIFIC REPORTS, 6, 20161117
  15. Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 480(2), 166-172, 20161111
  16. The physiological roles of ER stress transducer BBF2H7/CREB3L2 and its potential as a target of disease therapy, Medical Research Archives, 20160805
  17. Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells, PLoS One, 8, e55155, 20130130
  18. Unfolded protein response activated by OASIS family transcription factors promotes astrocyte differentiation, Nature Communications, 3, 967, 20120724
  19. Vanadate inhibits endoplasmic reticulum stress responses. European Journal of Pharmacology, European Journal of Pharmacology, 594, 44-48, 20081010
  20. Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis, FASEB JOURNAL, 34(1), 865-880, 202001
  21. The broad spectrum of signaling pathways regulated by unfolded protein response in neuronal homeostasis, NEUROCHEMISTRY INTERNATIONAL, 119, 26-34, 201810
  22. Diverse functions of protein tyrosine phosphatase sigma in the nervous and immune systems, EXPERIMENTAL NEUROLOGY, 302, 196-204, 201804
  23. Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma, JOURNAL OF NEUROCHEMISTRY, 144(1), 35-49, 201801
  24. ER Stress and Disease: Toward Prevention and Treatment, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(9), 1337-1343, 201709
  25. The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(5), 617-625, 201610
  26. Signaling over distance, Molecular & Cellular Proteomics, 15, 382-393, 2016
  27. Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells, Human Molecular Genetics, 24, 299-313, 2015
  28. Promotion of cancer cell proliferation by cleaved and secreted luminal domains of ER stress transducer BBF2H7, PLoS One, 10, e0125982, 2015
  29. Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2, Molecular Cell, 53, 127-139, 2014
  30. Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice, PLoS One, 9, e88048, 2014
  31. Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation ofthe ER Stress Transducer BBF2H7/CREB3L2 in Chondrocytes, Journal of Biological Chemistry, 289, 13810-13820, 2014
  32. Physiological functions of endoplasmic reticulum stress transducer OASIS in central nervous system, Anatomical Science International, 89, 11-20, 2014
  33. Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue, Scientific Reports, 2, 799, 2012
  34. Activation of OASIS family, ER stress transducers, is dependent on its stabilization, Death & Differentiation, 19, 1939-1949, 2012
  35. The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine, Journal of Biological Chemistry, 287, 8144-8153, 2012
  36. The endoplasmic reticulum stress transducer BBF2H7 suppresses apoptosis by activating the ATF5-MCL1 pathway in growth plate cartilage, Journal of Biological Chemistry, 287, 36190-36200, 2012
  37. ER stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in osteoblast differentiation induced by BMP2, Journal of Biological Chemistry, 286, 4809-4818, 2011
  38. Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors, IUBMB Life, 63, 233-239, 2011
  39. The signaling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellullar physiology, Journal of Biochemistry, 149, 507-518, 2011
  40. Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis, Journal of Bone and Mineral Metabolism, 28, 131-138, 2010
  41. Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice, Journal of Bone and Mineral Metabolism, 28, 384-394, 2010
  42. Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death, Investigative Ophthalmology & Visual Science, 50, 334-344, 2009
  43. Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice, Journal of Neurochemistry, 110, 956-965, 2009
  44. Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis, Nature Cell Biology, 11, 1197-1204, 2009
  45. Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation, Nature Cell Biology, 11, 1205-1211, 2009
  46. A novel ER stress transducer, OASIS, expressed in astrocytes, Antioxidants & Redox Signaling, 9, 563-571, 2007
  47. Endoplasmic reticulum stress response in dendrites of cultured primary neurons, 146, 1-8, 2007
  48. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer, Molecular and Cellular Biology, 27, 1716-1729, 2007
  49. Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1, Human Molecular Genetics, 16, 2834-2843, 2007
  50. Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress, Journal of Neurochemistry, 96, 1090-1100, 2006
  51. Autophagy is activated for cell survival after endoplasmic reticulum stress, Molecular and Cellular Biology, 26, 9220-9231, 2006
  52. Candidates for tumor-specific alternative splicing, Biochemical and Biophysical Research Communications, 334, 23-29, 2005

Invited Lecture, Oral Presentation, Poster Presentation

  1. Regulations of cellular senescence in glioblastoma mediated by ER-resident transcription factor OASIS, Atsushi Saito, Tetsuro Yoshimaru, Yosuke Matsushita, Toyomasa Katagiri, Kazunori Imaizumi, The 64th Annual Meeting of the Japanese Society for Neurochemistry, 2021/09/30, Without Invitation, Japanese
  2. Recovery of lysosomal functions by the shutdown of ER-associated degradation and therapy of mucopolysaccharidosis, Atsushi Saito, Yosuke Osaki, Kazunori Imaizumi, NEURO2019 (The 42nd Annual Meeting of the Japan Neuroscience Society and The 62nd Annual Meeting of the Japanese Society for Neurochemistry), 2019/07/28, With Invitation, English, Niigata
  3. The roles of ER-resident transmembrane transcription factor OASIS in cellular senescence of astrocytes, Matsuhisa K, Saito A, Asada R, Kaneko M, Imaizumi K, NEURO2019, 2019/07/26, Without Invitation, English, Niigata
  4. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, Osaki Y, Saito A, Masaaki T, Orii K, Fukao T, Tomatsu S, Imaizumi K, ASCB | EMBO 2018 Meeting, 2018/12/09, Without Invitation, English, San Diego, USA
  5. Neuronal activity-dependent formation of ER-PM contact sites in spines regulates spine formation and dendritic extension via local manipulation of unfolded protein response, Saito A, Imaizumi K, Society for Neuroscience 2018, 2018/11/04, Without Invitation, English, San Diego, USA
  6. Retrograde propagation of signaling regulated by UPR branches promotes peripheral nerve regeneration, 2017/12/09, Without Invitation, Japanese
  7. Axon Regeneration Promoted by Signaling of the Unfolded Protein Response in Peripheral Nerve Injury, Ohtake Y, Saito A, Imaizumi K., Society for Neuroscience 2017, 2017/11/15, Without Invitation, English, Washington D. C., USA
  8. Dendritic expansion and spine formation regulated by signaling pathways of unfolded protein response, Saito A., Imaizumi K., Society for Neuroscience 2017, 2017/09/07, Without Invitation, English, SENDAI, JAPAN
  9. ER stress-dependent production of small peptides derived from ER stress sensors in neuronal cells, Saito A., Matsuhisa K., Ohtake Y., Yanagida K., Okochi M., Matsumoto M., Nakayama K., Imaizumi K., 2017/09/09, Without Invitation, Japanese
  10. Dendritic expansion and spine formation regulated by signaling pathways of unfolded protein response, Saito A, Imaizumi K, 2017/09/07, With Invitation, English
  11. Signaling of the Unfolded Protein Response is Critical for Axon Regeneration after Nerve Injury, 2017/09/07, Without Invitation, Japanese
  12. Skeletal cell differentiation and tissue formation regulated by endoplasmic reticulum-derived signaling, Saito A., Imaizumi K., The 14th Bone Biology Forum, 2017/08/18, With Invitation, English, THIBA
  13. Chondrocyte proliferation regulated by liminal domain of ER stress transducer BBF2H7, Saito A., Imaizumi K., The 8th Bone Research Seminar, 2014/02, Without Invitation, English, TOKYO
  14. Luman, an ER stress transducer, is involved in osteoclastogenesis through the regulation of DC-STAMP expression, Saito A., Kanemoto S., Saito A., Kobayashi T., Miyamoto T., Takahashi N., Imaizumi K., ANZBMS 23rd Annual Scientific Meeting, 2013/09, Without Invitation, Japanese, Melbourne, Australia
  15. Chondrocyte proliferation controlled by secreted partial fragments of endoplasmic reticulum stress transducer BBF2H7, Saito A., Asada R., Iwamoto H., Izumi S., Kanemoto S., Imaizumi K., IBMS-JSBMR 2013, 2013/05, Without Invitation, English, KOBE, JAPAN
  16. Secreted partial fragments of ER stress transducer BBF2H7 promote proliferation of neighboring cells via activation of hedgehog signaling, Saito A., Asada R., Iwamoto H., Izumi S., Kanemoto S., Zhang Y., Kamon M., Imaizumi K., ASBMB Special Symposia Series 2013, The Malutitasking Endoplasmic Reticulum in Health and Disease, 2013/05, Without Invitation, English, Virginia, U.S.A.
  17. The endoplasmic reticulum stress sensor BBF2H7 suppresses apoptosis by activating ATF5-MCL1 pathway in chondrocytes, Saito A., Izumi S., Ochi M., Imaizumi K., IBMS-JSBMR 2013, 2013/05, Without Invitation, English, KOBE, JAPAN
  18. Unfolded protein response activated by OASIS family transcription factors is involved in astrocyte differentiation, 2013/03, Without Invitation, Japanese
  19. The role of ER stress transducer OASIS in astrocyte differentiation, Saito A., Sanosaka T., Nakashima K., Imaizumi K., The 2012 meeting on Molecular Chaperones & Stress Responses, 2012/05, Without Invitation, English, New York, U.S.A.
  20. The role of an ER-resident transmembrane transcription factor OASIS in astrocyte differentiation, 2011/09, Without Invitation, Japanese
  21. Autophagy system is activated during ER stress via the ER-resident transmembrane kinase IRE1, Saito A., Ogata M., Urano F., Imaizumi K., 2005/12, Without Invitation, English, FUKUOKA
  22. IRE1-JNK pathway is essential for activation of autophagy after ER stress, Saito A., Ogata M., Hino S-I., Urano F., Imaizumi K., 2006/09, Without Invitation, English
  23. The role of an ER-resident transmembrane transcription factor OASIS in astrocyte differentiation, Saito A., Kondo S., Kanemoto S., Sanosaka T., Nakashima K., Wanaka A., Imaizumi K., The 41th annual meeting of the Society for Neuroscience, 2011/11, Without Invitation, English
  24. CREB/ATF transcription factors regulate astrocyte differentiation by fine-tuning the Gcm1 expression, 2011/08, Without Invitation, Japanese
  25. The role of ER stress transducer OASIS in astrocyte differentiation, 2011/03, Without Invitation, Japanese
  26. The role of ER stress transducer OASIS in astrocyte differentiation, Saito A., The 3rd international symposium on protein community, 2010/09, Without Invitation, English, NARA
  27. The role of ER stress response in astrocyte differentiation, Saito A., Ochiai K., Murakami T., Sanosaka T., Nakashima K., Wanaka A., Imaizumi K., The 2010 meeting on Molecular Chaperones & Stress Responses, 2010/05, Without Invitation, Japanese, New York, U.S.A.
  28. Regulation of ER stress response by BBF2H7/Sec23a pathway is essential for chondrogenesis, Saito A., Imaizumi K., The 26th Naito Conference on Osteobiology, 2009/11, Without Invitation, English, Awaji, Hyogo
  29. Increased vulnerability of pyramidal neurons to the toxicity of kainic acid in the hippocampi of OASIS-deficient mice, Saito A., Ochiai K., Murakami T., Sanosaka T., Nakashima K., Wanaka A., Imaizumi K., The 39th Annual Meeting of the Society for Neuroscience, 2009/10, Without Invitation, Japanese, Chicago, U.S.A.
  30. A novel Endoplasmic Reticulum stress transducer BBF2H7 expressed in injured neurons, Saito A., Hino S-I., Imaizumi K., The 38th annual meeting of the Society for Neuroscience, 2008/11, Without Invitation, English, Washington D.C., U.S.A.
  31. Autophagy is activated for cell survival after ER stress, 2006/11, Without Invitation, Japanese

Patented

  1. Patent, 米国JP番号9695235, 2017/07/04
  2. Patent, JP番号6233932, 2017/11/02