ATSUSHI SAITO

Last Updated :2022/08/04

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor
E-mail
saitoahiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Nara Institute of Science and Technology
  • Miyazaki University

Affiliated Academic Societies

  • Society for Neuroscience

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Year, Physiology and Biochemistry
  2. 2022, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry

Research Activities

Academic Papers

  1. The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(5), 617-625, 201610
  2. Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 480(2), 166-172, 20161111
  3. The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression, SCIENTIFIC REPORTS, 6, 20161117
  4. ER Stress and Disease: Toward Prevention and Treatment, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(9), 1337-1343, 201709
  5. Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma, JOURNAL OF NEUROCHEMISTRY, 144(1), 35-49, 201801
  6. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183, PLOS ONE, 13(1), 20180104
  7. Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury, NEUROSCIENCE, 375, 34-48, 20180401
  8. Diverse functions of protein tyrosine phosphatase sigma in the nervous and immune systems, EXPERIMENTAL NEUROLOGY, 302, 196-204, 201804
  9. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, CELL DEATH & DISEASE, 9(808), 20180724
  10. The broad spectrum of signaling pathways regulated by unfolded protein response in neuronal homeostasis, NEUROCHEMISTRY INTERNATIONAL, 119, 26-34, 201810
  11. Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria, and Plasma Membrane, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 20181018
  12. Osteoregulation by Physiological Stresses. Endoplasmic reticulum stress response in osteogenesis., 23(11), 21-27, 2013
  13. Candidates for tumor-specific alternative splicing, Biochemical and Biophysical Research Communications, 334, 23-29, 2005
  14. Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress, Journal of Neurochemistry, 96, 1090-1100, 2006
  15. Autophagy is activated for cell survival after endoplasmic reticulum stress, Molecular and Cellular Biology, 26, 9220-9231, 2006
  16. A novel ER stress transducer, OASIS, expressed in astrocytes, Antioxidants & Redox Signaling, 9, 563-571, 2007
  17. Endoplasmic reticulum stress response in dendrites of cultured primary neurons, 146, 1-8, 2007
  18. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer, Molecular and Cellular Biology, 27, 1716-1729, 2007
  19. Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1, Human Molecular Genetics, 16, 2834-2843, 2007
  20. Vanadate inhibits endoplasmic reticulum stress responses. European Journal of Pharmacology, European Journal of Pharmacology, 594, 44-48, 20081010
  21. Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death, Investigative Ophthalmology & Visual Science, 50, 334-344, 2009
  22. Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice, Journal of Neurochemistry, 110, 956-965, 2009
  23. Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis, Nature Cell Biology, 11, 1197-1204, 2009
  24. Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation, Nature Cell Biology, 11, 1205-1211, 2009
  25. Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis, Journal of Bone and Mineral Metabolism, 28, 131-138, 2010
  26. Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice, Journal of Bone and Mineral Metabolism, 28, 384-394, 2010
  27. ER stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in osteoblast differentiation induced by BMP2, Journal of Biological Chemistry, 286, 4809-4818, 2011
  28. Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors, IUBMB Life, 63, 233-239, 2011
  29. The signaling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellullar physiology, Journal of Biochemistry, 149, 507-518, 2011
  30. Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue, Scientific Reports, 2, 799, 2012
  31. Activation of OASIS family, ER stress transducers, is dependent on its stabilization, Death & Differentiation, 19, 1939-1949, 2012
  32. The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine, Journal of Biological Chemistry, 287, 8144-8153, 2012
  33. The endoplasmic reticulum stress transducer BBF2H7 suppresses apoptosis by activating the ATF5-MCL1 pathway in growth plate cartilage, Journal of Biological Chemistry, 287, 36190-36200, 2012
  34. Unfolded protein response activated by OASIS family transcription factors promotes astrocyte differentiation, Nature Communications, 3, 967, 20120724
  35. Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells, PLoS One, 8, e55155, 20130130
  36. Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2, Molecular Cell, 53, 127-139, 2014
  37. Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice, PLoS One, 9, e88048, 2014
  38. Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation ofthe ER Stress Transducer BBF2H7/CREB3L2 in Chondrocytes, Journal of Biological Chemistry, 289, 13810-13820, 2014
  39. Physiological functions of endoplasmic reticulum stress transducer OASIS in central nervous system, Anatomical Science International, 89, 11-20, 2014
  40. Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells, Human Molecular Genetics, 24, 299-313, 2015
  41. Promotion of cancer cell proliferation by cleaved and secreted luminal domains of ER stress transducer BBF2H7, PLoS One, 10, e0125982, 2015
  42. Signaling over distance, Molecular & Cellular Proteomics, 15, 382-393, 2016
  43. The physiological roles of ER stress transducer BBF2H7/CREB3L2 and its potential as a target of disease therapy, Medical Research Archives, 20160805
  44. NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells, Journal of Biological Chemistry, 294(1), 101-105, 20190104
  45. Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(1), 217-223, 20190618
  46. Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(2), 436-442, 20190625
  47. Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation., Scientific Reports, 9(1), 20301, 20191230
  48. Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis, FASEB JOURNAL, 34(1), 865-880, 202001
  49. Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its beta 1 subunit, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 521(4), 1030-1035, 20200122
  50. Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells, BRAIN RESEARCH, 1749, 20201215

Invited Lecture, Oral Presentation, Poster Presentation

  1. Recovery of lysosomal functions by the shutdown of ER-associated degradation and therapy of mucopolysaccharidosis, Atsushi Saito, Yosuke Osaki, Kazunori Imaizumi, NEURO2019 (The 42nd Annual Meeting of the Japan Neuroscience Society and The 62nd Annual Meeting of the Japanese Society for Neurochemistry), 2019/07/28, With Invitation, English, Niigata
  2. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, Osaki Y, Saito A, Masaaki T, Orii K, Fukao T, Tomatsu S, Imaizumi K, ASCB | EMBO 2018 Meeting, 2018/12/09, Without Invitation, English, San Diego, USA
  3. Neuronal activity-dependent formation of ER-PM contact sites in spines regulates spine formation and dendritic extension via local manipulation of unfolded protein response, Saito A, Imaizumi K, Society for Neuroscience 2018, 2018/11/04, Without Invitation, English, San Diego, USA
  4. Retrograde propagation of signaling regulated by UPR branches promotes peripheral nerve regeneration, 2017/12/09, Without Invitation, Japanese
  5. Axon Regeneration Promoted by Signaling of the Unfolded Protein Response in Peripheral Nerve Injury, Ohtake Y, Saito A, Imaizumi K., Society for Neuroscience 2017, 2017/11/15, Without Invitation, English, Washington D. C., USA
  6. Dendritic expansion and spine formation regulated by signaling pathways of unfolded protein response, Saito A., Imaizumi K., Society for Neuroscience 2017, 2017/09/07, Without Invitation, English, SENDAI, JAPAN
  7. ER stress-dependent production of small peptides derived from ER stress sensors in neuronal cells, Saito A., Matsuhisa K., Ohtake Y., Yanagida K., Okochi M., Matsumoto M., Nakayama K., Imaizumi K., 2017/09/09, Without Invitation, Japanese
  8. Dendritic expansion and spine formation regulated by signaling pathways of unfolded protein response, Saito A, Imaizumi K, 2017/09/07, With Invitation, English
  9. Signaling of the Unfolded Protein Response is Critical for Axon Regeneration after Nerve Injury, 2017/09/07, Without Invitation, Japanese
  10. Skeletal cell differentiation and tissue formation regulated by endoplasmic reticulum-derived signaling, Saito A., Imaizumi K., The 14th Bone Biology Forum, 2017/08/18, With Invitation, English, THIBA
  11. Chondrocyte proliferation regulated by liminal domain of ER stress transducer BBF2H7, Saito A., Imaizumi K., The 8th Bone Research Seminar, 2014/02, Without Invitation, English, TOKYO
  12. Luman, an ER stress transducer, is involved in osteoclastogenesis through the regulation of DC-STAMP expression, Saito A., Kanemoto S., Saito A., Kobayashi T., Miyamoto T., Takahashi N., Imaizumi K., ANZBMS 23rd Annual Scientific Meeting, 2013/09, Without Invitation, Japanese, Melbourne, Australia
  13. Chondrocyte proliferation controlled by secreted partial fragments of endoplasmic reticulum stress transducer BBF2H7, Saito A., Asada R., Iwamoto H., Izumi S., Kanemoto S., Imaizumi K., IBMS-JSBMR 2013, 2013/05, Without Invitation, English, KOBE, JAPAN
  14. Secreted partial fragments of ER stress transducer BBF2H7 promote proliferation of neighboring cells via activation of hedgehog signaling, Saito A., Asada R., Iwamoto H., Izumi S., Kanemoto S., Zhang Y., Kamon M., Imaizumi K., ASBMB Special Symposia Series 2013, The Malutitasking Endoplasmic Reticulum in Health and Disease, 2013/05, Without Invitation, English, Virginia, U.S.A.
  15. The endoplasmic reticulum stress sensor BBF2H7 suppresses apoptosis by activating ATF5-MCL1 pathway in chondrocytes, Saito A., Izumi S., Ochi M., Imaizumi K., IBMS-JSBMR 2013, 2013/05, Without Invitation, English, KOBE, JAPAN
  16. Unfolded protein response activated by OASIS family transcription factors is involved in astrocyte differentiation, 2013/03, Without Invitation, Japanese
  17. The role of ER stress transducer OASIS in astrocyte differentiation, Saito A., Sanosaka T., Nakashima K., Imaizumi K., The 2012 meeting on Molecular Chaperones & Stress Responses, 2012/05, Without Invitation, English, New York, U.S.A.
  18. The role of an ER-resident transmembrane transcription factor OASIS in astrocyte differentiation, 2011/09, Without Invitation, Japanese
  19. Autophagy system is activated during ER stress via the ER-resident transmembrane kinase IRE1, Saito A., Ogata M., Urano F., Imaizumi K., 2005/12, Without Invitation, English, FUKUOKA
  20. IRE1-JNK pathway is essential for activation of autophagy after ER stress, Saito A., Ogata M., Hino S-I., Urano F., Imaizumi K., 2006/09, Without Invitation, English
  21. The role of an ER-resident transmembrane transcription factor OASIS in astrocyte differentiation, Saito A., Kondo S., Kanemoto S., Sanosaka T., Nakashima K., Wanaka A., Imaizumi K., The 41th annual meeting of the Society for Neuroscience, 2011/11, Without Invitation, English
  22. CREB/ATF transcription factors regulate astrocyte differentiation by fine-tuning the Gcm1 expression, 2011/08, Without Invitation, Japanese
  23. The role of ER stress transducer OASIS in astrocyte differentiation, 2011/03, Without Invitation, Japanese
  24. The role of ER stress transducer OASIS in astrocyte differentiation, Saito A., The 3rd international symposium on protein community, 2010/09, Without Invitation, English, NARA
  25. The role of ER stress response in astrocyte differentiation, Saito A., Ochiai K., Murakami T., Sanosaka T., Nakashima K., Wanaka A., Imaizumi K., The 2010 meeting on Molecular Chaperones & Stress Responses, 2010/05, Without Invitation, Japanese, New York, U.S.A.
  26. Regulation of ER stress response by BBF2H7/Sec23a pathway is essential for chondrogenesis, Saito A., Imaizumi K., The 26th Naito Conference on Osteobiology, 2009/11, Without Invitation, English, Awaji, Hyogo
  27. Increased vulnerability of pyramidal neurons to the toxicity of kainic acid in the hippocampi of OASIS-deficient mice, Saito A., Ochiai K., Murakami T., Sanosaka T., Nakashima K., Wanaka A., Imaizumi K., The 39th Annual Meeting of the Society for Neuroscience, 2009/10, Without Invitation, Japanese, Chicago, U.S.A.
  28. A novel Endoplasmic Reticulum stress transducer BBF2H7 expressed in injured neurons, Saito A., Hino S-I., Imaizumi K., The 38th annual meeting of the Society for Neuroscience, 2008/11, Without Invitation, English, Washington D.C., U.S.A.
  29. Autophagy is activated for cell survival after ER stress, 2006/11, Without Invitation, Japanese

Patented

  1. Patent, 米国JP番号9695235, 2017/07/04
  2. Patent, JP番号6233932, 2017/11/02