tomoichiro asano

Last Updated :2023/11/01

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
E-mail
tasanohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, The University of Tokyo

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Metabolomics

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 2Term, Cell Science
  2. 2023, Undergraduate Education, Year, Physiology and Biochemistry
  3. 2023, Undergraduate Education, 2Term, Introduction for medical research
  4. 2023, Undergraduate Education, Intensive, Practice for medical research
  5. 2023, Undergraduate Education, 4Term, Clinicobiochemistry
  6. 2023, Graduate Education (Master's Program) , First Semester, Seminar
  7. 2023, Graduate Education (Master's Program) , Second Semester, Seminar
  8. 2023, Graduate Education (Master's Program) , First Semester, Research
  9. 2023, Graduate Education (Master's Program) , Second Semester, Research
  10. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  11. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  12. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  13. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  14. 2023, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry
  15. 2023, Graduate Education (Master's Program) , 1Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance A
  16. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Biomedical Chemistry
  17. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Biomedical Chemistry
  18. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Biomedical Chemistry
  19. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Biomedical Chemistry

Research Activities

Academic Papers

  1. Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression., Diabetes Res Clin Pract., 135-142, 20060201
  2. DNA microarray analyses of genes expressed differentially in 3T3-L1 adipocytes co-cultured with murine macrophage cell line RAW264.7 in the presence of the toll-like receptor 4 ligand bacterial endotoxin, international journal of obesity, 32, 1725-1729, 20080901
  3. Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis., J. Biol. Chem., 286(23), 20812-20822, 20110701
  4. Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications., Innate Imunity, 20110101
  5. Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase, OBESITY RESEARCH & CLINICAL PRACTICE, 4(3), E201-E207, 2010
    Link to Paper Search Results by DOI
  6. Distinct roles of autophagy in the heart during ischemia and reperfusion - Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy, CIRCULATION RESEARCH, 100(6), 914-922, 20070330
    Link to Paper Search Results by DOI
  7. Calpain 6 is involved in microtubule stabilization and cytoskeletal organization, MOLECULAR AND CELLULAR BIOLOGY, 27(7), 2548-2561, 200704
    Link to Paper Search Results by DOI
  8. Protein kinase A-regulated nucleocytoplasmic shuttling of Id1 during angiogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(23), 17200-17209, 20070608
    Link to Paper Search Results by DOI
  9. AMPK mediates autophagy during myocardial ischemia in vivo, AUTOPHAGY, 3(4), 405-407, 2007
    Link to Paper Search Results by DOI
  10. Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 293(5), C1576-C1585, 200711
    Link to Paper Search Results by DOI
  11. SH3 domain of the phosphatidylinositol 3-kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 365(3), 433-438, 20080118
    Link to Paper Search Results by DOI
  12. Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126, DEVELOPMENT, 135(24), 3989-3993, 20081215
    Link to Paper Search Results by DOI
  13. Maintenance of genomic methylation patterns during preimplantation development require's the somatic form of DNA methyltransferase 1, DEVELOPMENTAL BIOLOGY, 313(1), 335-346, 20080101
    Link to Paper Search Results by DOI
  14. Regulation of gut-derived resistin-like molecule beta expression by nutrients, DIABETES RESEARCH AND CLINICAL PRACTICE, 79(1), 2-10, 200801
    Link to Paper Search Results by DOI
  15. Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 294(3), F542-F553, 200803
    Link to Paper Search Results by DOI
  16. Regulation of Pancreatic beta Cell Mass by Neuronal Signals from the Liver, SCIENCE, 322(5905), 1250-1254, 20081121
    Link to Paper Search Results by DOI
  17. Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 294(4), E719-E725, 200804
    Link to Paper Search Results by DOI
  18. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats, JOURNAL OF CLINICAL INVESTIGATION, 118(8), 2959-2968, 200808
    Link to Paper Search Results by DOI
  19. AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3 beta and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoenolpyruvate Carboxykinase C Gene Expression in the Liver, JOURNAL OF BIOLOGICAL CHEMISTRY, 283(49), 33902-33910, 20081205
    Link to Paper Search Results by DOI
  20. Long-term Forskolin Stimulation Induces AMPK Activation and Thereby Enhances Tight junction Formation in Human Placental Trophoblast BeWo Cells, PLACENTA, 29(12), 1003-1008, 200812
    Link to Paper Search Results by DOI
  21. Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 296(1), E157-E164, 200901
    Link to Paper Search Results by DOI
  22. Growth Hormone Inhibition of Glucose Uptake in Adipocytes Occurs without Affecting GLUT4 Translocation through an Insulin Receptor Substrate-2-Phosphatidylinositol 3-Kinase-dependent Pathway, JOURNAL OF BIOLOGICAL CHEMISTRY, 284(10), 6061-6070, 20090306
    Link to Paper Search Results by DOI
  23. Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappa B activity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 394(3), 697-702, 20100409
    Link to Paper Search Results by DOI
  24. Activation of AMP-activated Protein Kinase Suppresses Oxidized Low-density Lipoprotein-induced Macrophage Proliferation, JOURNAL OF BIOLOGICAL CHEMISTRY, 284(50), 34561-34569, 20091211
    Link to Paper Search Results by DOI
  25. Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 404(3), 767-773, 20110121
    Link to Paper Search Results by DOI
  26. Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy, DIABETES RESEARCH AND CLINICAL PRACTICE, 87(1), 57-63, 201001
    Link to Paper Search Results by DOI
  27. Specific Roles of the p110 alpha Isoform of Phosphatidylinsositol 3-Kinase in Hepatic Insulin Signaling and Metabolic Regulation, CELL METABOLISM, 11(3), 220-230, 20100303
    Link to Paper Search Results by DOI
  28. Paraquat-induced Oxidative Stress Represses Phosphatidylinositol 3-Kinase Activities Leading to Impaired Glucose Uptake in 3T3-L1 Adipocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(27), 20915-20925, 20100702
    Link to Paper Search Results by DOI
  29. Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest, JOURNAL OF CLINICAL INVESTIGATION, 120(8), 2817-2828, 201008
    Link to Paper Search Results by DOI
  30. Nuclear IKK beta Is an Adaptor Protein for I kappa B alpha Ubiquitination and Degradation in UV-Induced NF-kappa B Activation, MOLECULAR CELL, 39(4), 570-582, 20100827
    Link to Paper Search Results by DOI
  31. Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(43), 33018-33027, 20101022
    Link to Paper Search Results by DOI
  32. Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1, JOURNAL OF CELL SCIENCE, 124(8), 1214-1223, 20110415
    Link to Paper Search Results by DOI
  33. 4F2hc stabilizes GLUT1 protein and increases glucose transport activity, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 300(5), C1047-C1054, 201105
    Link to Paper Search Results by DOI
  34. Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(23), 20812-20822, 20110610
    Link to Paper Search Results by DOI
  35. HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 344(1-2), 81-89, 20110915
    Link to Paper Search Results by DOI
  36. Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: Potential link with metabolic complications, INNATE IMMUNITY, 18(1), 164-170, 201202
    Link to Paper Search Results by DOI
  37. Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and Atherosclerosis Development, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(2), 291-U282, 201202
    Link to Paper Search Results by DOI
  38. Valsartan, independently of AT1 receptor or PPAR gamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302(3), E286-E296, 201202
    Link to Paper Search Results by DOI
  39. Blockade of the Nuclear Factor-kappa B Pathway in the Endothelium Prevents Insulin Resistance and Prolongs Life Spans, CIRCULATION, 125(9), 1122-U140, 20120306
    Link to Paper Search Results by DOI
  40. Prolyl Isomerase Pin1 Regulates Mouse Embryonic Fibroblast Differentiation into Adipose Cells, PLOS ONE, 7(3), 20120307
    Link to Paper Search Results by DOI
  41. Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 423(1), 122-127, 20120622
    Link to Paper Search Results by DOI
  42. Phosphatidylinositol 3-Kinase (PI3K) Activity Bound to Insulin-like Growth Factor-I (IGF-I) Receptor, which Is Continuously Sustained by IGF-I Stimulation, Is Required for IGF-I-induced Cell Proliferation, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(35), 29713-29721, 20120824
    Link to Paper Search Results by DOI
  43. Integrator complex plays an essential role in adipose differentiation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434(2), 197-202, 20130503
    Link to Paper Search Results by DOI
  44. Importance of endothelial NF-kappa B signalling in vascular remodelling and aortic aneurysm formation, CARDIOVASCULAR RESEARCH, 97(1), 106-114, 20130101
    Link to Paper Search Results by DOI
  45. Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(53), 44526-44535, 20121228
    Link to Paper Search Results by DOI
  46. LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8, OBESITY RESEARCH & CLINICAL PRACTICE, 6(3), E215-E224, 2012
    Link to Paper Search Results by DOI
  47. Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages, OBESITY RESEARCH & CLINICAL PRACTICE, 6(4), E288-E297, 2012
    Link to Paper Search Results by DOI
  48. Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes, FEBS LETTERS, 587(15), 2319-2324, 20130802
    Link to Paper Search Results by DOI
  49. Par14 Protein Associates with Insulin Receptor Substrate 1 (IRS-1), Thereby Enhancing Insulin-induced IRS-1 Phosphorylation and Metabolic Actions, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(28), 20692-20701, 20130712
    Link to Paper Search Results by DOI
  50. Resistin-Like Molecule Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(8), 1986-1993, 201308
    Link to Paper Search Results by DOI
  51. Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 305(12), G911-G918, 201312
    Link to Paper Search Results by DOI
  52. The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease, NEPHROLOGY DIALYSIS TRANSPLANTATION, 29(3), 611-618, 201403
    Link to Paper Search Results by DOI
  53. Mediobasal hypothalamic PTEN modulates hepatic insulin resistance independently of food intake in rats, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 307(1), E47-E60, 20140701
    Link to Paper Search Results by DOI
  54. A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 78(5), 832-838, 201405
    Link to Paper Search Results by DOI
  55. Insulin Receptor Substrate-4 Binds to Slingshot-1 Phosphatase and Promotes Cofilin Dephosphorylation, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(38), 26302-26313, 20140919
    Link to Paper Search Results by DOI
  56. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 308(2), G151-G158, 20150115
    Link to Paper Search Results by DOI
  57. Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity, NATURE COMMUNICATIONS, 6, 201504
    Link to Paper Search Results by DOI
  58. Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines, PLOS ONE, 10(6), 20150603
    Link to Paper Search Results by DOI
  59. High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice, DIABETOLOGY & METABOLIC SYNDROME, 7, 20150602
    Link to Paper Search Results by DOI
  60. LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis, MEDIATORS OF INFLAMMATION, 2015
    Link to Paper Search Results by DOI
  61. Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling, OBESITY, 23(7), 1460-1471, 201507
    Link to Paper Search Results by DOI
  62. The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 309(1), G42-G51, 20150701
    Link to Paper Search Results by DOI
  63. Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet, PLOS ONE, 10(8), 20150812
    Link to Paper Search Results by DOI
  64. DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-kappa B activation, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 309(3), E214-E223, 20150801
    Link to Paper Search Results by DOI
  65. A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals, NATURE COMMUNICATIONS, 6, 201508
    Link to Paper Search Results by DOI
  66. Prolyl Isomerase Pin1 Negatively Regulates AMP-activated Protein Kinase (AMPK) by Associating with the CBS Domain in the gamma Subunit, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(40), 24255-24266, 20151002
    Link to Paper Search Results by DOI
  67. Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis., Frontiers in Endocrinology, 5, 1-12, 201403
  68. Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus., Diabetology & metabolic syndrome, 7, 104, 20151119
  69. Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus, DIABETOLOGY & METABOLIC SYNDROME, 7, 20151119
    Link to Paper Search Results by DOI
  70. Involvement of resistin-like molecule beta in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice, SCIENTIFIC REPORTS, 6, 20160128
    Link to Paper Search Results by DOI
  71. IL-17A synergistically enhances TNF alpha-induced IL-6 and CCL20 production in 3T3-L1 adipocytes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 477(2), 241-246, 20160819
    Link to Paper Search Results by DOI
  72. Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17(9), 201609
    Link to Paper Search Results by DOI
  73. Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis, MEDIATORS OF INFLAMMATION, 2016
    Link to Paper Search Results by DOI
  74. Reduced SHARPIN and LUBAC Formation May Contribute to CCl4- or Acetaminophen-Induced Liver Cirrhosis in Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(2), 201702
    Link to Paper Search Results by DOI
  75. USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 484(3), 522-528, 20170311
    Link to Paper Search Results by DOI
  76. Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 27(3), 249-259, 201703
    Link to Paper Search Results by DOI
  77. The prolyl isomerase Pin1 increases beta-cell proliferation and enhances insulin secretion, JOURNAL OF BIOLOGICAL CHEMISTRY, 292(28), 11886-11895, 20170714
    Link to Paper Search Results by DOI
  78. The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(8), 201708
    Link to Paper Search Results by DOI
  79. Trk-fused gene (TFG) regulates pancreatic beta cell mass and insulin secretory activity, SCIENTIFIC REPORTS, 7, 20171012
    Link to Paper Search Results by DOI
  80. A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs, CELL REPORTS, 21(9), 2628-2638, 20171128
    Link to Paper Search Results by DOI
  81. Gut Microbiota as a Therapeutic Target for Metabolic Disorders, CURRENT MEDICINAL CHEMISTRY, 25(9), 984-1001, 2018
    Link to Paper Search Results by DOI
  82. Effects of the Activation of Three Major Hepatic Akt Substrates on Glucose Metabolism in Male Mice, ENDOCRINOLOGY, 158(8), 2659-2671, 201708
    Link to Paper Search Results by DOI
  83. Neuronal signals regulate obesity induced beta-cell proliferation by FoxM1 dependent mechanism, NATURE COMMUNICATIONS, 8, 20171205
    Link to Paper Search Results by DOI
  84. Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages., Mediators of Inflammation, Article ID 3062319, 2018
  85. Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 201810
    Link to Paper Search Results by DOI
  86. The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(12), 201812
    Link to Paper Search Results by DOI
  87. ★, Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16, CELL REPORTS, 26(12), 3221-+, 20190319
    Link to Paper Search Results by DOI
  88. Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocyt es and Macrophages, MEDIATORS OF INFLAMMATION, 2018
    Link to Paper Search Results by DOI
  89. Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure, NUTRITION & METABOLISM, 16, 20190704
    Link to Paper Search Results by DOI
  90. Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice, DIABETOLOGY & METABOLIC SYNDROME, 11, 20190722
    Link to Paper Search Results by DOI
  91. Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(19), 201910
    Link to Paper Search Results by DOI
  92. Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins, CELLS, 8(12), 201912
    Link to Paper Search Results by DOI
  93. Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells, CANCER LETTERS, 470, 106-114, 2020
    Link to Paper Search Results by DOI
  94. Development of Pin1 Inhibitors and their Potential as Therapeutic Agents, CURRENT MEDICINAL CHEMISTRY, 27(20), 3314-3329, 2020
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Role Of Xanthine Oxidoreductase From Mesenchymal Cells In Retinal Inflammation After Pericyte Breakdown, AKIFUMI KUSHIYAMA, TAKAKO KIKUCHI, TAKESHI YAMAMOTOYA, HIDEYUKI SAKODA, MIDORI FUJISHIRO, TOMOICHIRO ASANO, YASUHIKO IWAMOTO, AKIFUMI KUSHIYAMA, TAKAKO KIKUCHI, TAKESHI YAMAMOTOYA, HIDEYUKI SAKODA, MIDORI FUJISHIRO, TOMOICHIRO ASANO, YASUHIKO IWAMOTO, 78th Scientific Sessions, American Diabetes Association, 2018/06/22, Without Invitation, English
  2. Mechanism Mediated by S6 Kinase Resulting in both Sufficient Glucose Metabolism Improvement and Insufficient Weight Loss by Glucose Excretion against Fat Load, TAKAKO KIKUCHI, AKIFUMI KUSHIYAMA, MIDORI FUJISHIRO, HIDEYUKI SAKODA, TOMOICHIRO ASANO, YASUHIKO IWAMOTO, TAKAKO KIKUCHI, AKIFUMI KUSHIYAMA, MIDORI FUJISHIRO, HIDEYUKI SAKODA, TOMOICHIRO ASANO, YASUHIKO IWAMOTO, 78th Scientific Sessions, American Diabetes Association, 2018/06/22, Without Invitation, English
  3. The role of prolyl isomerase Pin1 in beta cell functions, Yusuke Nakatsu, Keiichi Mori, Yasuka Matsunaga, Toshiaki Fukushima, Hideaki Kamata, Ken Yamaguchi, Hisamitsu Ishihara, Tomoichiro Asano, 75th American diabetes association, 2015/06/05, Without Invitation, English, American diabetes association