TAKASHI TODA

Last Updated :2023/06/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor (Special Appointment)
Web Site
http://mccb.hiroshima-u.ac.jp/
E-mail
takashi-todahiroshima-u.ac.jp
Self-introduction
I am a specially appointed professor at Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University. I started this position in October 2015. I had been running my own research group for the past 21 years in the Francis Crick Institute (formerly Cancer Research UK London Research Institute) as a senior principle investigator. My research area is molecular cell biology and I have been investigating the molecular mechanisms of how cells divides and chromosomes segregate equally during mitosis.

Basic Information

Academic Degrees

  • Ph.D. of Science, Kyoto University

Educational Activity

Course in Charge

  1. 2023, Graduate Education (Master's Program) , Academic Year, Seminar in Biotechnology
  2. 2023, Graduate Education (Master's Program) , 1Term, Exercises in Biotechnology A
  3. 2023, Graduate Education (Master's Program) , 2Term, Exercises in Biotechnology A
  4. 2023, Graduate Education (Master's Program) , 3Term, Exercises in Biotechnology B
  5. 2023, Graduate Education (Master's Program) , 4Term, Exercises in Biotechnology B
  6. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biotechnology
  7. 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences

Research Activities

Academic Papers

  1. Complementation of fission yeast kinesin-5/Cut7 with human Eg5 provides a versatile platform for screening of anticancer compounds, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 86(2), 254-259, 20220124
    Link to Paper Search Results by DOI
  2. A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation, EMBO REPORTS, 17(3), 326-337, 201603
  3. Synergistic role of fission yeast Alp16GCP6 and Mzt1MOZART1 in γ-tubulin complex recruitment to mitotic spindle pole bodies and spindle assembly, Mol Biol Cell, 27, 2016
  4. The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast, Cell Cycle, 15, 740-747, 2016
  5. The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation, Biochem Biophys Res Commun, 468, 39-45, 2015
  6. Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast, Genes Cells, 20, 1046-1058, 2015
  7. Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5, ELIFE, 5, 20160730
  8. Regulation of centriolar satellite integrity and its physiology, CELLULAR AND MOLECULAR LIFE SCIENCES, 74(2), 213-229, 201701
    Link to Paper Search Results by DOI
  9. Purification and characterisation of the fission yeast Ndc80 complex, PROTEIN EXPRESSION AND PURIFICATION, 135, 61-69, 201707
    Link to Paper Search Results by DOI
  10. Identification of three signaling molecules required for calcineurin-dependent monopolar growth induced by the DNA replication checkpoint in fission yeast, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 491(4), 883-889, 20170930
    Link to Paper Search Results by DOI
  11. A microtubule polymerase cooperates with the kinesin-6 motor and a microtubule cross-linker to promote bipolar spindle assembly in the absence of kinesin-5 and kinesin-14 in fission yeast, MOLECULAR BIOLOGY OF THE CELL, 28(25), 3647-3659, 20171201
    Link to Paper Search Results by DOI
  12. Two spatially distinct kinesin-14 proteins, Pkl1 and Klp2, generate collaborative inward forces against kinesin-5 Cut7 in S. pombe, JOURNAL OF CELL SCIENCE, 131(1), 201801
    Link to Paper Search Results by DOI
  13. Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth, NATURE CELL BIOLOGY, 13(3), 234-U357, 2011
  14. Casein Kinase 1 gamma Ensures Monopolar Growth Polarity under Incomplete DNA Replication Downstream of Cds1 and Calcineurin in Fission Yeast, MOLECULAR AND CELLULAR BIOLOGY, 35(9), 1533-1542, 2015
  15. Fission yeast MOZART1/Mzt1 is an essential gamma-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly, MOLECULAR BIOLOGY OF THE CELL, 24(18), 2894-2906, 2013
  16. The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies, JOURNAL OF CELL BIOLOGY, 209(4), 549-562, 2015
  17. An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation, JOURNAL OF CELL SCIENCE, 129(24), 4592-4606, 2016
  18. Fission yeast cells overproducing HSET/KIFC1 provides a useful tool for identification and evaluation of human kinesin-14 inhibitors, FUNGAL GENETICS AND BIOLOGY, 116, 33-41, 201807
    Link to Paper Search Results by DOI
  19. Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe, G3-GENES GENOMES GENETICS, 9(1), 269-280, 201901
    Link to Paper Search Results by DOI
  20. Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast, SCIENTIFIC REPORTS, 9, 20190514
    Link to Paper Search Results by DOI
  21. Kinesin-8 and Dis1/TOG collaborate to limit spindle elongation from prophase to anaphase A for proper chromosome segregation in fission yeast, JOURNAL OF CELL SCIENCE, 132(18), 201909
    Link to Paper Search Results by DOI
  22. Two XMAP215/TOG Microtubule Polymerases, Alp14 and Dis1, Play Non-Exchangeable, Distinct Roles in Microtubule Organisation in Fission Yeast, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(20), 20191002
    Link to Paper Search Results by DOI
  23. Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells, BIOORGANIC & MEDICINAL CHEMISTRY, 28(1), 20200101
    Link to Paper Search Results by DOI
  24. Generation of temperature sensitive mutations with error-prone PCR in a gene encoding a component of the spindle pole body in fission yeast, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 83(9), 1717-1720, 20191102
    Link to Paper Search Results by DOI
  25. How essential Kinesin-5 becomes non-essential in fission yeast: force balance and microtubule dynamics matter, Cells, 9(5), E1154-E1154, 2020
    Link to Paper Search Results by DOI
  26. Escape from mitotic catastrophe by actin-dependent nuclear displacement in fission yeast, ISCIENCE, 24(1), 20210122
    Link to Paper Search Results by DOI
  27. The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(9), 202105
    Link to Paper Search Results by DOI
  28. KIFC1 regulates ZWINT to promote tumor progression and spheroid formation in colorectal cancer, PATHOLOGY INTERNATIONAL, 71(7), 441-452, 202107
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. The Molecular Mechanism of Anchoring the Microtubules to the Spindle Pole Body and the Centrosome, 2016/02, With Invitation, English, Yukio Fujiki,
  2. Exploring the Molecular Mechanim of Mitotic Progression and Control: The Spindle Microtubule as a key player, Takashi Toda, 2016/08/01, With Invitation, English, Professor Kazuhiro Maeshima, National Institute for Genetics
  3. Exploring the molecular mechanism of mitotic progression and control: The spindle microtubule as a key player, Takashi Toda, 2016/05/20, With Invitation, English, Professor Shin-ichi Tate, RcMcD, Hiroshima University

External Funds

Acceptance Results of Competitive Funds

  1. Scientific Research (A), 2016, 2021
  2. Challenging Exploratory Research, 2016, 2019
  3. KAKENHI, 2016, 2020
  4. KAKENHI, 2016, 2018