Kazuhiko Sugiyama

Last Updated :2022/07/01

Affiliations, Positions
Hiroshima University Hospital, Professor
E-mail
brainhiroshima-u.ac.jp
Self-introduction
My speciality is clinical oncology and subspeciality is neuo-oncology, that means medical therapy for malignant neoplasum of central nervous system. I have also been interested in basic/ translational research of malignant neoplasum of central nervous system and clinical study of various kinds of malignant neoplasum.

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Neurosurgery
  • Medicine,dentistry, and pharmacy;Clinical internal medicine;General internal medicine (including psychosomatic medicine)

Research Keywords

  • Phase II study|germ cell tumors
  • survivor|brain tumor
  • temozolomide|glioma
  • P16
  • central nervous system
  • childhood
  • glioblastoma
  • Brain Tumor
  • medical economics
  • Clinical Oncology

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Year, Systemic Disease Control
  2. 2022, Graduate Education (Doctoral Program) , 1Term, Practice of Oncology
  3. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Clinical Oncology
  4. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Clinical Oncology
  5. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Clinical Oncology
  6. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Clinical Oncology
  7. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Clinical Practice of Systemic Chemotherapy
  8. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Clinical Practice of Systemic Chemotherapy
  9. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pediatric Cancer Treatment
  10. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pediatric Cancer Treatment
  11. 2022, Undergraduate Education, Year, Systemic Disease Control
  12. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Clinical Oncology
  13. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Clinical Oncology
  14. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Clinical Oncology
  15. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Clinical Oncology
  16. 2022, Graduate Education (Doctoral Program) , 1Term, Practice of Oncology
  17. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Clinical Practice of Systemic Chemotherapy
  18. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Clinical Practice of Systemic Chemotherapy
  19. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pediatric Cancer Treatment
  20. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pediatric Cancer Treatment

Research Activities

Academic Papers

  1. Immunohistochemical study of Ki-67 (MIB-1), p53 protein, p21(WAF1), and p27(KIP1) expression in benign, atypical, and anaplastic meningiomas, HUMAN PATHOLOGY, 32(9), 970-975, 200109
    Link to Paper Search Results by DOI
  2. Case of clear cell ependymoma of medulla oblongata: Clinicopathological and immunohistochemical study with literature review, PATHOLOGY INTERNATIONAL, 53(5), 297-302, 200305
    Link to Paper Search Results by DOI
  3. Role of perfusion-weighted imaging at 3 T in the histopathological differentiation between astrocytic and oligodendroglial tumors, EUROPEAN JOURNAL OF RADIOLOGY, 81(8), 1863-1869, 201208
    Link to Paper Search Results by DOI
  4. Lymphomas and glioblastomas: Differences in the apparent diffusion coefficient evaluated with high b-value diffusion-weighted magnetic resonance imaging at 3 T, EUROPEAN JOURNAL OF RADIOLOGY, 81(2), 339-344, 201202
    Link to Paper Search Results by DOI
  5. Pathologic diversity of glioneuronal tumor with neuropil-like islands: A histological and immunohistochemical study with a special reference to isocitrate dehydrogenase 1 (IDH1) in 5 cases, CLINICAL NEUROPATHOLOGY, 31(2), 67-76, 2012
    Link to Paper Search Results by DOI
  6. Evaluation of cerebellar mutism by arterial spin-labeling perfusion magnetic resonance imaging in a patient with atypical teratoid/rhabdoid tumor (AT/RT): a case report, CHILDS NERVOUS SYSTEM, 28(8), 1257-1260, 201208
    Link to Paper Search Results by DOI
  7. Advantages of high b-value diffusion-weighted imaging to diagnose pseudo-responses in patients with recurrent glioma after bevacizumab treatment, EUROPEAN JOURNAL OF RADIOLOGY, 81(10), 2805-2810, 201210
    Link to Paper Search Results by DOI
  8. Phase II Study of Single-agent Bevacizumab in Japanese Patients with Recurrent Malignant Glioma(dagger), JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 42(10), 887-895, 201210
    Link to Paper Search Results by DOI
  9. Preoperative histological grading of meningiomas using apparent diffusion coefficient at 3T MRI, EUROPEAN JOURNAL OF RADIOLOGY, 82(4), 658-663, 201304
    Link to Paper Search Results by DOI
  10. Gangliogliona of the optic pathway A case report, Surgical Neurology, 37, 1, 19910401
  11. Intracranial germ-cell tumors with synchronous lesions in the pineal and suprasellar regions, Surgical Neurology, 38, 2, 19920401
  12. Pineocytomas : Clinicopathological evaluation of 4 cases, Neurological Surgery, 20, 4, 19920401
  13. Clinical Evaluation of 33 Patients with Histologically Verified Germinoma., Surgical Neurology, 43(3), 200, 19940401
  14. Germinoma of the Medulla Oblongata -Case Report-, Neurologia Medico-chirurgica, 34(5), 291, 19940401
  15. Mesenchymal chondorosarcoma in Anterior Skull Base-case Report-, Brain tumor Pathology, 13, 19960401
  16. Recurrence of Meningiomas influence of varcular endothelial growth facfor expression, Cancer, 89, 1102, 20000401
  17. Peritunroral brain edema associated with meningioma. Influence of vascular endothelial growth factor expression and vascular blood supply, Cancer, 85, 936, 19990401
  18. Intrasellar rhabdomyosarcoma: Case Report, Neurosurgery, 48, 677-680
  19. Morphologic features of HCG- and AFP-producing germ cell tumors of the centralnervous system - Histological heterogeneity and surgical meanings -, Brain Tumor Pathol., 18, 61-67
  20. Surgical treatment for intractable epilipsy caused by cavernous angioma in the temporal lobe of the dominant hemisphere -Three case report-, Neurologia medico-chirugica (Tokyo), 40, 439-445
  21. Assence of Mutations in the NBS1 gene in B-cell malignant lymphoma patients, Anticancer Research, 20, 1897-1900
  22. Recurrence of meningiomas Influence of vascular endothelial growth factor expression, Cancer, 89, 1102-1110
  23. Idipatic granulomatous meningoencepalitis presenting as an intracranial tumor, Pathology International, 49, 1084-1088
  24. Peritumoral Brain Edema Associated with Meningioma, Cancer, 85, 936-944
  25. Third ventriculostomy for patients with obstructive hydrocephalus caused by tumors, Proceedings 12th World Congress of Neurosurgery, 572-574, 20010401
  26. Intrasellar rhabdomyosarcoma: Case report, Neurosurgery, 48, 677-680, 20010401
  27. Thickening of sphenoid sinus mucosa during the acute stage of pituitary apoplexy, Journal of Neurosurgery, 95, 897-901, 20010401
  28. Thicking of sphenoid sinus mucosa during the acute stage of pituitary apoplexy, Journal of Neurosurgery, 95, 897-901
  29. Immunohistochemical study of Ki-67 (MIB-1), p53 protein, p21WAF1, p27KIP1expression in benign, atypical, and anplastic meningiomas, Human Pathology, 32, 970-975
  30. Falcotentorial meningioma accompanied by temporal lobe hematoma, Hiroshima Journal of Medical Science, 50(5), 66-71, 20010401
  31. Intrasellar rhabdomyosarcoma: Case report, Neurosurgery, 48, 677-680, 20010401
  32. Thickening of sphenoid sinus mucosa during the acute stage of pituitary apoplexy, Journal of Neurosurgery, 95, 897-901, 20010401
  33. Surgical Treatment for Intractable Epilepsy Caused by Cavernous Angioma in the Temporal Lobe of the Dominant Hemisphere -Three case Reports-, Neurologia Medico-chirurgica, 40, 439-445, 20000401
  34. Recurrence of meningiomas, Cancer, 1102-1110, 20000401
  35. Absence of mutations in the NBS1 gene in B-cell malignant lymphoma patients., Anticancer Research, 20, 1897-1900, 20000401
  36. Peritumoral brain edema associated with meningioma: influence of vascular endothelial growth factor expression and vascular blood supply., Cancer, 86, 936-944, 19990401
  37. MRI of intracranial germ cell tumours, Neuroradiology, 37, 32-37, 19950401
  38. Clinical evaluation of 33 patients with histologically verified germinoma, Surgical Neurology, 42, 200-210, 19940401
  39. Germinoma of the medulla oblongata - Case report -, Neurologia medico-chirurgica (Tokyo), 34, 291-294, 19940401
  40. Intracranial germ-cell tumor with synchronous lesions in the pineal and duprasellar regions: Report of six cases and review of the literature, Surgical Neurology, 38, 114-120, 19920401
  41. Transfer of G-CSF Gene into Human Glioma Cells: Effect on the Proliferation of Glioma Cells in Nude Mice, EXPERIMENTAL ONCOLOGY, 20, 198-203
  42. Transformation of rat glioma cells with the M-CSF gene inhibits tumorigenesis in vivo, Journal of Neuro-Oncology, 40, 197-204
  43. nduction and maintenance therapy for high grade glioma of cerebral hemisphere using ACNU, platinum. ang CSG ( PARM+JAM therapy ), 411-415
  44. Telomerase Activity in Human Brain Tumors, 1787-1791
  45. Mesenchymal Chondorosarcoma in Anterior Skull Base -Case Report-, Brain tumor Pathology, 13, 57-60
  46. Clinicopathological Growth Factors of Acoustic Neuromas, Surgical Neurology, 43, 546-552
  47. MRI of Intracranial Germ Cell Tumors, Neuroradiology, 37, 32-37
  48. Combined Antitumor Effects of TNF and G-CSF on a Human Medulloblastoma Xenograft Line, Journal of Neuro-Oncology, 21, 203-213
  49. Antitumor Effects of Antiprogesterones on Human Meningioma Cells in vitro and in vivo, Journal of Neurosurgery, 80, 527-534
  50. Clinical Evaluation of 33 Patients with Histologically Verified Germinoma, Surgical Neurology, 42, 200-210
  51. Germinoma of the Medulla Oblongata -Case Report, Neurologia Medico-chirurgica, 34, 291-294
  52. Malignant Astrocytoma with Extracranial Metastasis: A Case Report, Brain tumor Pathology, 10, 145-149
  53. Analysis and Distribution of Etoposide in Rat Brain Tumor Model: Intracarotid Versus Intravenous with Angiotensin II-induced Hypertention, Cacer Investigation, 11, 299-305
  54. Intracranial Germ-cell Tumor with Synchronous Lesions in the Pineal and Suprasellar Regions: Report of Six Cases and Review of the Literature, Surgical Neurology, 38, 114-120
  55. Effect of Intracarotid Infusion of Etoposide with Angiotensin II-induced Hypertension on the Blood-brain Barrier and the Brain Tissue, Journal of Neuro-Oncology, 13, 111-117
  56. Penetration of Etoposide into human Malignant Brain Tumors after Intravenous and Oral Administration, Cancer Chemotherapy and Pharmacology, 29, 339-342
  57. Intracranial Metastasis from a Spinal Cord Primitive Neuroectodermal Tumor:Case Report, Surgical Neurology, 37, 307-312
  58. Ganglioglioma of the Optic Pathway A Case Repor, Surgical Neurology, 37, 22-25
  59. Outcome of Primary Central Nervous System Lymphoma, Neurologia Medico-chirurgica, 31, 194-198
  60. Establishment and Characterization of Human Medulloblastoma Zenograft Line, Hiroshima Journal of Medical Science, 40, 41-45
  61. Embryonal Carcinoma in Early Infancy, Brain tumor Pathology, 8, 99-102
  62. Multiple Oligodendroglioma -Case Report-, Neurologia Medico-chirurgica, 30, 127-131
  63. Third ventriculostomy for patients with obstructive hydrocephalus caused by tumors, Proceedings 12th World Congress of Neurosurgery, 572-574, 20010401
  64. Thickening of sphenoid sinus mucosa during the acute stage of pituitary apoplexy, Journal of Neurosurgery, 897-901, 20010401
  65. Surgical Treatment for Intractable Epilepsy Caused by Cavernous Angioma in the Temporal Lobe of the Dominant Hemisphere -Three case Reports-, Neurologia Medico-chirurgica, 439-445, 20000401
  66. Recurrence of meningiomas, Cancer, 1102-1110, 20000401
  67. Absence of mutations in the NBS1 gene in B-cell malignant lymphoma patients., Anticancer Research, 1897-1900, 20000401
  68. Peritumoral brain edema associated with meningioma: influence of vascular endothelial growth factor expression and vascular blood supply., Cancer, 936 ? 44, 19990401
  69. Transformation of rat glioma cells with the M-CSF gene inhibits tumorigenesis in vivo.;, Journal of Neuro-Oncology, 197-204, 19980401
  70. Transfer of G-CSF Gene into Human Glioma Cells: Effect on the Proliferation of Glioma Cells in Nude Mice, EXPERIMENTAL ONCOLOGY, 198-203, 19980401
  71. Induction and maintenance therapy for high grade glioma of cerebral hemisphere using ACNU, platinum, and CSF(PARM + JAM therapy), 11th international congress of neurological surgery, 411-415, 19970401
  72. Telomerase activity in human brain tumors, 11th international congress of neurological surgery, 1787-1791, 19970401
  73. Mesenchymal chondrosarcoma in anterior skull base:case report, Brain tumor Pathology, 57-60, 19960401
  74. Incidental meningioma in autopsy cases in computed tomography and magnetic imaging era, Brain Tumor Research and Therapy, 79-88, 19960401
  75. MRI of intracranial germ cell tumours, Neuroradiology, 32-37, 19950401
  76. Clinicopathological growth factors of acoustic neuromas, Surgical Neurology, 546-552, 19950401
  77. Combined antitumor effects of TNF and G-CSF on a human medulloblastoma xenograft line, Journal of Neuro-Oncology, 203-213, 19940401
  78. Antitumor effects of antiprogesterones on human meningioma cells in vitro and in vivo, Journal of Neurosurgery, 527-534, 19940401
  79. Malignant astrocytoma with extracranial metastases: A case report, Brain tumor Pathology, 145-149, 19930401
  80. Analysis and distribution of etoposide in rat brain tumor model: intracarotid versus intravenous with sngiotensin II-induced hypertention, Cancer Investigation, 299-305, 19930401
  81. Effect of intracarotid infusion of etoposide with angiotensin II-induced hypertension on the blood-brain barrier and the brain tissue, Journal of Neuro-Oncology, 111-117, 19920401
  82. Intracranial germ-cell tumor with synchronous lesions in the pineal and duprasellar regions: Report of six cases and review of the literature, Surgical Neurology, 114-120, 19920401
  83. Intracranial metastasis from a spinal cord primitive neuroectodermal tumor: Case report, Surgical Neurology, 307-312, 19920401
  84. Penetration of etoposide into human malignant brain tumors after intravenous and oral administration, Cancer Chemotherapy and Pharmacology, 339-342, 19920401
  85. Establishment and characterization of human medulloblastoma zenograft Line, Hiroshima Journal of Medical Science, 41-45, 19910401
  86. Embryonal carcinoma in early infancy, Brain tumor Pathology, 99-102, 19910401
  87. Outcome of primary central nervous system lymphoma, Neurologia medico-chirurgica (Tokyo), 194-198, 19910401
  88. Meningioangiomatosis Occurring in a Young Male without Neurofibromatosis -With Special Reference to its Histogenesis and LOH in the NF2 Gene Region-, Am. J. Surg. Pathol., 26(1), 125-126, 20020101
  89. Surgical Treatment for Intractable Epilepsy Caused by Cavernous Angioma in the Temporal Lobe of the Dominant Hemisphere -Three case Reports-, Neurologia Medico-chirurgica, 40, 439-445, 20000401
  90. Synthesis of Poly(methyl methacrylate) Microspheres Bearing Phosphatidylcholine Analogous and Azobenzene Moieties, Polymer J., 25(5), 521-527, 19930401
  91. Synthesis of Poly(methylmethacrylate) Microspheres Bearing Phosphatidylcholine Analogous and Azobenzene Moieties, Polym. J.=, 25, 521-527, 19930401
  92. Multi-area generation expansion planning by means of multi-objective fuzzy linear programming, Proc. of 13th PSCC, 762-769, 19990401
  93. A proposal of a supporting expert system for outage planning of electric power facilities retaining high power supply reliability, Part II ~ Knowledge processing and simulation results, IEEE Trans. Power Systems, 13(4), 1459-1465, 19980401
  94. Multi-Area Generation Expansion Planning by Means of Multi-Objective Fuzzy Linear Programming, Proc. of 13th Power System Computation Conference (PSCC), 2, 762-769, 19990601
  95. The effects of difference in the thickness of racket frame and the string tension on tennis ball-racket impact, XIIIth International congress on biomechanics book of abstracts, 131-132, 19910401
  96. Analysis of sdi-1 Gene Functions in Human Malignant Glioma Brain Tumor Research and Therapy, Masakatsu Nagai ed.,, Springer-Verlag, 435-440
  97. Telomerase Activity in Human Brain Tumors, 11th International Congress of Neurological Surgery= Monduzzi Editore= Bologna, 1787-1791
  98. Incidental Meningiomas in Autopsy Cases in Computed Tomography and Magnetic Resonance Imaging Era, Springer-Verlag, 79-88
  99. Induction and maintenance therapy for high grade glioma of cerebral hemisphere using ACNU, platinum. ang CSG ( PARM+JAM therapy ), 11th International Congress of Neurological Surgery= Monduzzi Editore= Bologna, 411-415
  100. The Role of O6-Alkylguanine-DNA Alkyltransferase in Glioma in Resistance to ChloroethylnitrosoureaBiological Aspects of Brain Tumors, Kazuo Tabuchi, Springer-Verlag, 260-265
  101. Histological Aspects of Certain Benign Brain Tumors: Review of Current Topics Brain Tumor Research and Therapy, Masakatsu Nagai ed.,, Springer-Verlag, 21-28
  102. Morphologic features of human chorionic gonadotropin- or alphafetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning, Brain tumor Pathology, 18, 115-122, 20010401
  103. Absence of mutations in the NBS1 gene in B-cell malignant lymphoma patients., Anticancer Res., 20, 1897-1900, 20000401
  104. Myelodysplastic syndrome following therapy for brain tumor--two case reports., Neurologia Medico-chirurgica, 42(4), 170-174, 20020401
  105. Detection of a pineoblastoma with large central cyst in a young child., Children Nervous System, 18(3-4), 157-160, 20020401
  106. Staurosporine-induced apoptosis is independent of p16and p21and;achieved via arrest at G2/M and at G1 in U251MG human glioma cell line, Cancer Chemotherapy and Pharmacology, 51, 271-283, 20030401
  107. Consciousness disturbance caused by brain tumors., 27, 939-941, 20030401
  108. Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosis., Cancer, 97(4), 1077-1083, 20030401
  109. Myelodysplastic syndrome following therapy for brain tumor--two case reports., Neurologia Medico-chirurgica, 42(4), 170-174, 20020401
  110. Detection of a pineoblastoma with large central cyst in a young child., Children Nervous System, 18(3-4), 157-160, 20020401
  111. Staurosporine-induced apoptosis is independent of p16and p21and;achieved via arrest at G2/M and at G1 in U251MG human glioma cell line, Cancer Chemotherapy and Pharmacology, 51, 271-283, 20030401
  112. Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosis., Cancer, 97(4), 1077-1083, 20030401
  113. High-field Magnetization in PrCo2Ge2 Single Crystals, J. Phys. Soc. Jpn., 58, 394-397, 19890401
  114. Anisotropic Hydridization in a Heavy Fermion Compound UPdIn with Double Magnetic Transitions, J. Magn. Magn. Mat., 90-91, 507-509, 19900401
  115. Metamagnetic Transitions of UPdIn in High Magnetic Field., J. Magn. Magn. Mat., 90-91, 65-66, 19900401
  116. Model for the Magnetic Transition in UPdIn., J. Magn. Magn. Mat., 104-107, 27-28, 19920401
  117. Field-Induced Transition from a Presudogap State to a Heavy-Fermion State in the Kondo-lattice System CeNiSn., Physica B, 177, 177-180, 19920401
  118. Magnetic Phase Transitions in PrCo2Si2., Physica B, 177, 275-278, 19920401
  119. Transport and Magnetic Properties of the Heavy-Fermion Compounds UCu3+xGa2-x (0.1 < x < 0.8)., Physica B, 199-200, 31-33, 19940401
  120. Polymorphism and Heavy-Fermion Behavior in UAu2Sn, J. Magn. Magn. Mat. 140-144 (1995) ., 140-144, 1363-1364, 19950401
  121. High-field magnetization of Kondo semiconductors CeNiSn and CeRhSb, Physica B, 211, 223-226, 19950401
  122. Double Magnetic Transitions in UPt2In, Physica B, 223-224, 228-230, 19960401
  123. Magnetoresistance and energy gap of CeNiSn in high magnetic field, Physica B, 230-232, 683-686, 19970401
  124. Field Induced Quenching of the Energy Gap in Single Crystal CeNiSn, J. Phys. Soc. Jpn., 67, 2455-2459, 19980401
  125. Meningioangiomatosis occurring in a young male without neurofibromatosis: with special reference to its histogenesis and loss of heterozygosity in the NF2 gene region., Am. J. Surg. Pathol., 26(1), 125-129, 20020101
  126. Idiopathic granulomatous meningoencephalitis presenting as an intracranial tumor., Pathol. Int., 49(12), 1084-1088, 19991201
  127. Diffuse Enhancing Lesions of Whole Ventricle Walls(NEUROIMAGING and NEUROPATHOLOGY of BRAIN TUMORS), Japanese Journal of Neurosurgery, 16(2), 141-144, 20070201
  128. Extraction of a vanadium-binding substance (Vanadobin) from the blood cells of several ascidian species, Biological Bulletin, 179, 140-147, 19900401
  129. Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats., Neurosci Lett., 430(2), 109-14, 20080110
  130. Long-term results of conventional treatment of diencephalic pilocytic astrocytoma in infants, Childs Nerv Syst, 19, 145-151, 20030101
  131. Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas, Journal of Neurooncology, 77, 273-277, 20060331
  132. 1.Slow postoperative decline in blood concentraction of insulin-like growth factor-1(IGF1) on acromegalic patients, Endocrine Journal, 52, 125-130, 20051231
  133. Natural course of incidentally found nonfunctioning pituitary adenoma, with special reference to pituitary apoplexy during follow-up examination., J Neurosurg, 104(6), 884-891, 20060601
  134. Slow postoperative decline in blood concentration of insulin-like growth factor-1 (IGF-1) in acromegalic patients, Endocrine Jouranal, 52, 125-130, 20050201
  135. A first feasibility study of temozolomide for Japanese patients with recurrent anaplastic astrocytomaand glioblastoma multiforme., Int J Clin Oncol, 8, 301-304, 20030331
  136. Detection and differentiation of lactate and lipids by single-voxel proton MR spectroscopy, Neurosurg Review, 28, 267-277, 20050331
  137. Apparent diffusion coefficient of human brain tumors at MR imaging, Radiology, 235(3), 985-991, 20050301
  138. Role of PROPELLER diffusion weighted imaging and apparent diffusion coefficient in the diagnosis of sellar and parasellar lesions, Eur J Radiol, 74(3), 420-427, 20090401
  139. Role of PROPELLER diffusion-weighted imaging and apparent diffusion coefficient in the diagnosis of sellar and parasellar lesions, European Journal of Radiology, 74(3), 420-427, 20100601
  140. Role of PROPELLER diffusion-weighted imaging and apparent diffusion coefficient in the evaluation of pituitary adenomas, European Journal of Radiology, 20111101
  141. Glioblastoma treated with postoperative radio-chemotherapy: prognostic value of apparent diffusion coefficient at MR imaging., European Journal Of Radiology, 73(3), 532-7, 20100301
  142. Expression of phosphoprotein enriched in astrocytes 15 kDa (PEA-15) in astrocytic tumors: a novel approach of correlating malignancy grade and prognosis., J Neurooncol., 100(3), 449-457, 20101201
  143. Advantages of high b value diffusion-weighted imaging in the diagnosis of acute stroke - a case report., Cerebrovasc Dis., 27(6), 616-617, 20090601
  144. The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma., Anticancer Res., 29(2), 597-603, 20090201
  145. Quality of life of extremely long-time germinoma survivors mainly treated with radiotherapy., Prog Neurol Surg., 23, 130-139, 20090201
  146. Expression of vascular endothelial growth factor in dura mater of patients with moyamoya disease., Neurosurg Rev., 31(1), 77-81, 20080101
  147. Retinoblastoma protein prevents staurosporine-induced cell death in a retinoblastoma-defective human glioma cell line., Pathobiology., 74(1), 22-31, 20070701
  148. Geminin: a good prognostic factor in high-grade astrocytic brain tumors., Cancer, 109(5), 9419-956, 20070301
  149. A first feasibility study of temozolomide for Japanese patients with recurrent anaplastic astrocytoma and glioblastoma multiforme., Int J Clin Oncol., 8(5), 301-304, 20030301
  150. Desmoplastic/nodular medulloblastoma associated with anhidrotic ectodermal dysplasia, International Cancer Conference Journal, 2(3), 178-182, 20130701
  151. Meningioangiomatosis occurring in a young male without neurofibromatosis - With special reference to its histogenesis and loss of heterozygosity in the NF2 gene region, AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 26(1), 125-129, 200201
    Link to Paper Search Results by DOI
  152. Cerebellar ganglioglioma associated with a huge cyst: Case report, NEUROLOGICAL SURGERY, 30(5), 503-507, 200205
    Link to Paper Search Results by DOI
  153. Expression of survivin in astrocytic tumors - Correlation with malignant grade and prognosis, CANCER, 97(4), 1077-1083, 20030215
    Link to Paper Search Results by DOI
  154. Long-term results of conventional treatment of diencephalic pilocytic astrocytoma in infants, CHILDS NERVOUS SYSTEM, 19(3), 145-151, 200303
    Link to Paper Search Results by DOI
  155. Staurosporine-induced apoptosis is independent of p16 and p21 and achieved via arrest at G2/M and at GI in U251MG human glioma cell line, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 51(4), 271-283, 200304
    Link to Paper Search Results by DOI
  156. Slow postoperative decline in blood concentration of insulin-like growth factor-1 (IGF-1) in acromegalic patients, ENDOCRINE JOURNAL, 52(1), 125-130, 200502
    Link to Paper Search Results by DOI
  157. Apparent diffusion coefficient of human brain tumors at MR imaging, RADIOLOGY, 235(3), 985-991, 200506
    Link to Paper Search Results by DOI
  158. Detection and differentiation of lactate and lipids by single-voxel proton MR spectroscopy, NEUROSURGICAL REVIEW, 28(4), 267-277, 200510
    Link to Paper Search Results by DOI
  159. Prognosis of cerebellar glioblastomas: Correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas, ANTICANCER RESEARCH, 26(2B), 1351-1357, 2006
    Link to Paper Search Results by DOI
  160. Retinoblastoma protein prevents staurosporine-induced cell death in a retinoblastoma-defective human glioma cell line, PATHOBIOLOGY, 74(1), 22-31, 2007
    Link to Paper Search Results by DOI
  161. Geminin: A good prognostic factor in high-grade astrocytic brain tumors, CANCER, 109(5), 949-956, 20070301
    Link to Paper Search Results by DOI
  162. Survivin subcellular localization in high-grade astrocytomas: simultaneous expression in both nucleus and cytoplasm is negative prognostic marker, JOURNAL OF NEURO-ONCOLOGY, 82(2), 193-198, 200704
    Link to Paper Search Results by DOI
  163. A case of multiple meningiomas: Two lesions have different clinicopathological features, respectively, NEUROLOGICAL SURGERY, 35(9), 929-934, 200709
    Link to Paper Search Results by DOI
  164. Expression of vascular endothelial growth factor in dura mater of patients with moyamoya disease, NEUROSURGICAL REVIEW, 31(1), 77-81, 200801
    Link to Paper Search Results by DOI
  165. Primary diffuse leptomeningeal gliosarcomatosis, JOURNAL OF NEURO-ONCOLOGY, 86(2), 207-210, 200801
    Link to Paper Search Results by DOI
  166. Pleomorphic xanthoastrocytoma: a comparative pathological study between conventional and anaplastic types, HISTOPATHOLOGY, 52(2), 183-193, 200801
    Link to Paper Search Results by DOI
  167. Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells, BRITISH JOURNAL OF CANCER, 98(2), 345-355, 20080122
    Link to Paper Search Results by DOI
  168. Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats, NEUROSCIENCE LETTERS, 430(2), 109-114, 20080110
    Link to Paper Search Results by DOI
  169. Occipital transtentorial approach to pineal and juxta-pineal tumors: A guidance for safe surgery of the pineal-region tumor, NEUROLOGICAL SURGERY, 36(3), 207-222, 200803
    Link to Paper Search Results by DOI
  170. Atypical teratoid/rhabdoid tumour in sella turcica in an adult, ACTA NEUROCHIRURGICA, 150(5), 491-496, 200805
    Link to Paper Search Results by DOI
  171. Secondary anaplastic oligodendroglioma after cranial irradiation: a case report, JOURNAL OF NEURO-ONCOLOGY, 88(3), 299-303, 200807
    Link to Paper Search Results by DOI
  172. Metachronous mature teratoma in the corpus callosum occurring 12 years after a pineal germinoma, JOURNAL OF NEUROSURGERY, 109(1), 126-129, 200807
    Link to Paper Search Results by DOI
  173. Primary angiitis of the central nervous system mimicking dissemination from brainstem neoplasm: a case report, SURGICAL NEUROLOGY, 70(2), 182-185, 200808
    Link to Paper Search Results by DOI
  174. Familial occurrence of dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: Case report, NEUROSURGERY, 63(2), 370-372, 200808
    Link to Paper Search Results by DOI
  175. The Combination of Low Cytoplasmic and High Nuclear Expression of p27 Predicts a Better Prognosis in High-grade Astrocytoma, ANTICANCER RESEARCH, 29(2), 597-603, 200902
    Link to Paper Search Results by DOI
  176. Endovascular coil occlusion of ruptured vertebral artery dissecting aneurysm: A case report, NEUROLOGY ASIA, 14(2), 149-152, 200912
    Link to Paper Search Results by DOI
  177. Glioblastoma treated with postoperative radio-chemotherapy: Prognostic value of apparent diffusion coefficient at MR imaging, EUROPEAN JOURNAL OF RADIOLOGY, 73(3), 532-537, 201003
    Link to Paper Search Results by DOI
  178. Development of the Japanese version of the Pediatric Quality of Life Inventory (TM) Brain Tumor Module, HEALTH AND QUALITY OF LIFE OUTCOMES, 8, 20100414
    Link to Paper Search Results by DOI
  179. Role of PROPELLER diffusion weighted imaging and apparent diffusion coefficient in the diagnosis of sellar and parasellar lesions, EUROPEAN JOURNAL OF RADIOLOGY, 74(3), 420-427, 201006
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  180. Expression of phosphoprotein enriched in astrocytes 15 kDa (PEA-15) in astrocytic tumors: a novel approach of correlating malignancy grade and prognosis, JOURNAL OF NEURO-ONCOLOGY, 100(3), 449-457, 201012
    Link to Paper Search Results by DOI
  181. Relationship between cytokeratin staining patterns and clinico-pathological features in somatotropinomae, EUROPEAN JOURNAL OF ENDOCRINOLOGY, 163(4), 531-539, 201010
    Link to Paper Search Results by DOI
  182. Endovascular Coil Embolization for Ruptured Aneurysm Associated With Persistent Primitive Anterior Choroidal Artery -Case Report-, NEUROLOGIA MEDICO-CHIRURGICA, 51(2), 127-129, 201102
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  183. Intracranial Germinoma Presenting With Hemiatrophy - Follow-up Results and Literature Review -Two Case Reports-, NEUROLOGIA MEDICO-CHIRURGICA, 51(2), 148-152, 201102
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  184. MRI findings in patients with central neurocytomas with special reference to differential diagnosis from other ventricular tumours near the foramen of Monro, JOURNAL OF CLINICAL NEUROSCIENCE, 19(5), 681-686, 201205
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  185. Pineal mixed germ cell tumor with a synchronous sellar lesion in the sixth decade, BRAIN TUMOR PATHOLOGY, 28(2), 163-166, 201104
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  186. Post-operative hyponatremia in patients with pituitary adenoma: post-operative management with a uniform treatment protocol, ENDOCRINE JOURNAL, 58(5), 373-379, 201105
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  187. Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma, NEURO-ONCOLOGY, 13(7), 791-801, 201107
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  188. A multicenter phase I trial of combination therapy with interferon-beta and temozolomide for high-grade gliomas (INTEGRA study): the final report, JOURNAL OF NEURO-ONCOLOGY, 104(2), 573-577, 201109
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  189. Role of PROPELLER diffusion-weighted imaging and apparent diffusion coefficient in the evaluation of pituitary adenomas, EUROPEAN JOURNAL OF RADIOLOGY, 80(2), 412-417, 201111
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  190. Masked hyperprolactinemia: Tumor-derived factors inhibiting prolactin secretion caused by pituitary-stalk damage, JOURNAL OF CLINICAL NEUROSCIENCE, 18(12), 1651-1655, 201112
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  191. Supra-diaphragmatic Pituitary Adenoma Removed Through the Trans-tuberculum Sellae Approach - Case Report, NEUROLOGIA MEDICO-CHIRURGICA, 52(2), 91-95, 201202
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  192. Factors influencing self- and parent-reporting health-related quality of life in children with brain tumors, QUALITY OF LIFE RESEARCH, 22(1), 185-201, 201302
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  193. Application of 4D-CTA using 320-row area detector computed tomography on spinal arteriovenous fistulae: initial experience, NEUROSURGICAL REVIEW, 36(2), 289-296, 201304
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  194. The arginine and GHRP-2 tests as alternatives to the insulin tolerance test for the diagnosis of adult GH deficiency in Japanese patients: A comparison, ENDOCRINE JOURNAL, 60(1), 97-105, 20130120
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  195. Multiple antiplatelet therapy contributes to the reversible high signal spots on diffusion-weighted imaging in elective coiling of unruptured cerebral aneurysm, NEURORADIOLOGY, 55(4), 449-457, 201303
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  196. A Case of Adult Onset Medulloblastoma During Maintenance Chemotherapy for Anaplastic Astrocytoma One Year After Radiotherapy, TURKISH NEUROSURGERY, 23(4), 521-526, 201307
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  197. Electrocorticographic-Histopathologic Correlations Implying Epileptogenicity of Dysembryoplastic Neuroepithelial Tumor, NEUROLOGIA MEDICO-CHIRURGICA, 53(10), 676-687, 201310
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  198. Pituitary adenomas in childhood and adolescence with a focus on intratumoral hemorrhage, PITUITARY, 17(1), 1-6, 201402
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  199. A Multicenter Phase I/II Study of the BCNU Implant (Gliadel (R) Wafer) for Japanese Patients with Malignant Gliomas, NEUROLOGIA MEDICO-CHIRURGICA, 54(4), 290-301, 201404
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  200. Cancer-specific health-related quality of life in children with brain tumors, QUALITY OF LIFE RESEARCH, 23(4), 1059-1068, 201405
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  201. Impact of subclinical haemorrhage on the pituitary gland in patients with pituitary adenomas, CLINICAL ENDOCRINOLOGY, 80(5), 720-725, 201405
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  202. Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germinoma, NEURORADIOLOGY, 56(7), 525-534, 201407
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  203. Intraoperative cortico-cortical evoked potentials for the evaluation of language function during brain tumor resection: initial experience with 13 cases, JOURNAL OF NEUROSURGERY, 121(4), 827-838, 201410
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  204. Impact of Late Effects on Health-Related Quality of Life in Survivors of Pediatric Brain Tumors Motility Disturbance of Limb(s), Seizure, Ocular/Visual Impairment, Endocrine Abnormality, and Higher Brain Dysfunction, CANCER NURSING, 37(6), E1-E14, 2014
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  205. Postoperative fever specific to neuroendoscopic procedures, NEUROSURGICAL REVIEW, 37(1), 99-104, 201401
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  206. p16 Gene Transfer Induces Centrosome Amplification and Abnormal Nucleation Associated with Survivin Downregulation in Glioma Cells, PATHOBIOLOGY, 82(1), 1-8, 2015
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  207. The postirradiation incidence of cavernous angioma is higher in patients with childhood pineoblastoma or primitive neuroectodermal tumors than medulloblastoma, CHILDS NERVOUS SYSTEM, 31(6), 901-907, 201506
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  208. ★, Magnetic resonance spectroscopy detection of high lipid levels in intraaxial tumors without central necrosis: a characteristic of malignant lymphoma, JOURNAL OF NEUROSURGERY, 122(6), 1370-1379, 201506
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  209. Results of sequential chemoradiotherapy for intracranial germinoma, JAPANESE JOURNAL OF RADIOLOGY, 33(6), 336-343, 201506
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  210. Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7, PLOS ONE, 10(5), 20150508
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  211. ★, Human chorionic gonadotropin is expressed virtually in all intracranial germ cell tumors, JOURNAL OF NEURO-ONCOLOGY, 124(1), 23-32, 201508
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  212. Cavernous angioma after chemotherapy for desmoplastic/nodular medulloblastoma associated with anhidrotic ectodermal dysplasia, CHILDS NERVOUS SYSTEM, 32(2), 395-398, 201602
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  213. Diffusion-weighted imaging and the apparent diffusion coefficient on 3T MR imaging in the differentiation of craniopharyngiomas and germ cell tumors, NEUROSURGICAL REVIEW, 39(2), 207-213, 201604
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  214. Clinical features and natural course of acromegaly in patients with discordance in the nadir GH level on the oral glucose test and the IGF-1 value at 3 months after adenomectomy, NEUROSURGICAL REVIEW, 39(2), 313-318, 201604
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  215. Solitary Langerhans cell histiocytosis located in the neurohypophysis with a positive titer HCG-beta in the cerebrospinal fluid, CHILDS NERVOUS SYSTEM, 32(5), 901-904, 201605
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  216. Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy, ACTA NEUROPATHOLOGICA, 131(6), 889-901, 201606
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  217. The long-term recurrence of Rathke's cleft cysts as predicted by histology but not by surgical procedure, JOURNAL OF NEUROSURGERY, 125(4), 1002-1007, 201610
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  218. The Surgical Side Effects of Pseudocapsular Resection in Nonfunctioning Pituitary Adenomas, WORLD NEUROSURGERY, 93, 430-+, 201609
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  219. Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas, ACTA NEUROPATHOLOGICA, 133(3), 445-462, 201703
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  220. Multicentric Glioma Develops via a Mutant IDH1-Independent Pathway: Immunohistochemical Study of Multicentric Glioma, PATHOBIOLOGY, 84(2), 99-107, 2017
    Link to Paper Search Results by DOI
  221. Permeability Surface Area Product Using Perfusion Computed Tomography Is a Valuable Prognostic Factor in Glioblastomas Treated with Radiotherapy Plus Concomitant and Adjuvant Temozolomide, WORLD NEUROSURGERY, 97, 21-26, 201701
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  222. Transsphenoidal Posterior Pituitary Lobe Biopsy in Patients with Neurohypophysial Lesions, WORLD NEUROSURGERY, 99, 543-547, 201703
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  223. Advantage of High b Value Diffusion-Weighted Imaging for Differentiation of Hemangioblastoma from Brain Metastases in Posterior Fossa, WORLD NEUROSURGERY, 101, 643-650, 201705
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  224. Development of cystic malacia after high-dose cranial irradiation of pediatric CNS tumors in long-term follow-up, CHILDS NERVOUS SYSTEM, 33(6), 957-964, 201706
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  225. Diffuse leptomeningeal glioneuronal tumor (DLGNT) mimicking Whipple's disease: a case report and literature review, CHILDS NERVOUS SYSTEM, 33(8), 1411-1414, 201708
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  226. ★, Sellar Atypical Teratoid/Rhabdoid Tumor (AT/RT): A Clinicopathologically and Genetically Distinct Variant of AT/RT, Am J Surg Pathol, 41(7), 932-940, 2017
  227. High Expression of Glypican-1 Predicts Dissemination and Poor Prognosis in Glioblastomas, WORLD NEUROSURGERY, 105, 282-288, 201709
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  228. Role for loss of nuclear PTEN in a harbinger of brain metastases, JOURNAL OF CLINICAL NEUROSCIENCE, 44, 148-154, 201710
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  229. Review of Current Evidence Regarding Surgery in Elderly Patients with Meningioma, NEUROLOGIA MEDICO-CHIRURGICA, 57(10), 521-533, 201710
    Link to Paper Search Results by DOI
  230. Pitfalls of Neuroendoscopic Biopsy of Intraventricular Germ Cell Tumors, WORLD NEUROSURGERY, 106, 430-434, 201710
    Link to Paper Search Results by DOI
  231. Nonenhancing peritumoral hyperintense lesion on diffusion-weighted imaging in glioblastoma: a novel diagnostic and specific prognostic indicator, JOURNAL OF NEUROSURGERY, 128(3), 667-678, 201803
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  232. Prognostic implications of the subcellular localization of survivin in glioblastomas treated with radiotherapy plus concomitant and adjuvant temozolomide, JOURNAL OF NEUROSURGERY, 128(3), 679-684, 201803
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  233. Prognostic importance of temozolomide-induced neutropenia in glioblastoma, IDH-wildtype patients, NEUROSURGICAL REVIEW, 41(2), 621-628, 201804
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  234. Advantages of high b-value diffusion-weighted imaging for preoperative differential diagnosis between embryonal and ependymal tumors at 3 T MRI, EUROPEAN JOURNAL OF RADIOLOGY, 101, 136-143, 201804
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  235. Proton Magnetic Resonance Spectroscopy Detection of High Lipid Levels and Low Apparent Diffusion Coefficient Is Characteristic of Germinomas, WORLD NEUROSURGERY, 112, E84-E94, 201804
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  236. JCOG0911 INTEGRA study: a randomized screening phase II trial of interferon beta plus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma, JOURNAL OF NEURO-ONCOLOGY, 138(3), 627-636, 201807
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  237. ★, Effects of Surgery With Salvage Stereotactic Radiosurgery Versus Surgery With Whole-Brain Radiation Therapy in Patients With One to Four Brain Metastases (JCOG0504): A Phase III, Noninferiority, Randomized Controlled Trial., Journal of clinical oncology, 78, 2018
  238. ★, Employment status and termination among survivors of pediatric brain tumors: a cross-sectional survey., International Journal of Clinical Oncology, 23(5), 801-811, 2018
  239. ★, JCOG0911 INTEGRA study: a randomized screening phase II trial of interferon-betaplus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma.
  240. ★, Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas., Acta Neuropathologica, 133(3), 445-462, 2017
  241. ★, Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy., Acta Neuropathol., 131(6), 889-901, 201603
  242. ★, Human chorionic gonadotropin is expressed virtually in all intracranial germ cell tumors., J Neurooncol., 124(1), 23-32, 201508
  243. ★, Perfusion Computed Tomography Parameters Are Useful for Differentiating Glioblastoma, Lymphoma, and Metastasis., World Neurosurg., 2018(Epub ahead of print), 2018
  244. Advantages of high b-value diffusion-weighted imaging for preoperative differential diagnosis between embryonal and ependymal tumors at 3 T MRI., Eur J Radiol., 101, 136-143, 2018
  245. ★, Proton Magnetic Resonance Spectroscopy Detection of High Lipid Levels and Low Apparent Diffusion Coefficient Is Characteristic of Germinomas., World Neurosurg., 112, e84-e94, 2018
  246. RELA fusion-positive anaplastic ependymoma: molecular characterization and advanced MR imaging., Brain Tumor Pathol., 35(1), 41-45, 201801
  247. ★, Prognostic importance of temozolomide-induced neutropenia in glioblastoma, IDH-wildtype patients., Neurosurg Rev., 41(2), 621-628, 201804
  248. Review of Current Evidence Regarding Surgery in Elderly Patients with Meningioma., Neurol Med Chir (Tokyo)., 57(10), 521-533, 201708
  249. Pitfalls of Neuroendoscopic Biopsy of Intraventricular Germ Cell Tumors., World Neurosurg., 106, 430-434, 20170712
  250. Role for loss of nuclear PTEN in a harbinger of brain metastases., J Clin Neurosci., 44, 148-154, 20170705
  251. ★, Prognostic implications of the subcellular localization of survivin in glioblastomas treated with radiotherapy plus concomitant and adjuvant temozolomide., World Neurosurg, 105, 282-288, 201709
  252. ★, Prognostic implications of the subcellular localization of survivin in glioblastomas treated with radiotherapy plus concomitant and adjuvant temozolomide., J Neurosurg., 128(3), 679-684, 20170321
  253. Diffuse leptomeningeal glioneuronal tumor (DLGNT) mimicking Whipple's disease: a case report and literature review., Childs Nerv Syst., 33(8), 1411-1414, 20170405
  254. Development of cystic malacia after high-dose cranial irradiation of pediatric CNS tumors in long-term follow-up., Childs Nerv Syst., 33(6), 957-964, 201704
  255. Nonenhancing peritumoral hyperintense lesion on diffusion-weighted imaging in glioblastoma: a novel diagnostic and specific prognostic indicator., J Neurosurg., 128(3), 667-678, 20170331
  256. Advantage of High b Value Diffusion-Weighted Imaging for Differentiation of Hemangioblastoma from Brain Metastases in Posterior Fossa., World Neurosurg., 101, 643-650, 20170204
  257. Transsphenoidal Posterior Pituitary Lobe Biopsy in Patients with Neurohypophysial Lesions., World Neurosurg, 99, 543-547, 20161227
  258. Multicentric Glioma Develops via a Mutant IDH1-Independent Pathway: Immunohistochemical Study of Multicentric Glioma., Pathobiology., 87(2), 99-107, 20160928
  259. Astroblastoma: a distinct tumor entity characterized by alterations of the X chromosome and MN1 rearrangement., Brain Pathol, Epub ahead of print, 20171009
  260. Transient spontaneous regression of brainstem glioblastoma, Journal of Neurological Science, 62(5), 610-612, 2018
  261. Perfusion Computed Tomography Parameters Are Useful for Differentiating Glioblastoma, Lymphoma, and Metastasis., World Neurosurg., Epub ahead of print, 20180809
  262. Advantages of high b-value diffusion-weighted imaging for preoperative differential diagnosis between embryonal and ependymal tumors at 3 T MRI., Eur J Radiol., 101, 136-143, 201804
  263. Sellar Atypical Teratoid/Rhabdoid Tumor (AT/RT): A Clinicopathologically and Genetically Distinct Variant of AT/RT, AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 41(7), 932-940, 201707
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  264. Perfusion Computed Tomography Parameters Are Useful for Differentiating Glioblastoma, Lymphoma, and Metastasis, WORLD NEUROSURGERY, 119, E890-E897, 201811
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  265. Astroblastoma: a distinct tumor entity characterized by alterations of the X chromosome and MN1 rearrangement, BRAIN PATHOLOGY, 28(5), 684-694, 201809
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  266. A prospective, multicentre, single-arm clinical trial of bevacizumab for patients with surgically untreatable, symptomatic brain radiation necrosis, NEURO-ONCOLOGY PRACTICE, 3(4), 272-280, 201612
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  267. Immunostaining of Increased Expression of Enhancer of Zeste Homolog 2 (EZH2) in Diffuse Midline Glioma H3K27M-Mutant Patients with Poor Survival, PATHOBIOLOGY, 86(2), 152-161, 2019
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  268. A Japanese nationwide survey on the cryopreservation of embryos, oocytes and ovarian tissue for cancer patients, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 45(10), 2021-2028, 201910
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  269. Usefulness of Histogram-Profile Analysis in Ring-Enhancing Intracranial Lesions, WORLD NEUROSURGERY, 131, E226-E236, 201911
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  270. Integrated clinical, histopathological, and molecular data analysis of 190 central nervous system germ cell tumors from the iGCT Consortium, NEURO-ONCOLOGY, 21(12), 1565-1577, 201912
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  271. Utility of dual-energy CT for predicting the vascularity of meningiomas, EUROPEAN JOURNAL OF RADIOLOGY, 123, 202002
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  272. Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature, WORLD NEUROSURGERY, 134, E360-E371, 202002
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  273. T2-FLAIR mismatch sign in dysembryoplasticneuroepithelial tumor, EUROPEAN JOURNAL OF RADIOLOGY, 126, 202005
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  274. Intratumoural immune cell landscape in germinoma reveals multipotent lineages and exhibits prognostic significance, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 46(2), 111-124, 202002
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  275. Effect of bevacizumab against cystic components of brain tumors, CANCER MEDICINE, 8(15), 6519-6527, 201911
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  276. ★, Phase 1/2 Study of Tirabrutinib, a Second-Generation Bruton's Tyrosine Kinase Inhibitor, in Relapsed/Refractory Primary Central Nervous System Lymphoma, Neuro-Oncology, online ahead of print., 20200725
  277. Current status and future perspectives of adult glioblastoma treatment - My thinking during the establishment of brain tumor guidelines in Japan -, Jpn J Cancer Chemother, 47(7), 1020-1025, 20200715
  278. Genetic analysis in patients with newly diagnosed glioblastomas treated with interferon-beta plus temozolomide in comparison with temozolomide alone, JOURNAL OF NEURO-ONCOLOGY, 148(1), 17-27, 202005
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  279. Advantage of high b value diffusion -weighted imaging for differentiation of common pediatric brain tumors in posterior fossa, EUROPEAN JOURNAL OF RADIOLOGY, 128, 202007
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  280. Radiology Profile as a Potential Instrument to Differentiate Between Posterior Fossa Ependymoma (PF-EPN) Group A and B, WORLD NEUROSURGERY, 140, E320-E327, 202008
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  281. Cerebrospinal fluid ctDNA and metabolites are informative biomarkers for the evaluation of CNS germ cell tumors, SCIENTIFIC REPORTS, 10(1), 20200831
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  282. Radiological and Immunostaining Characteristics of H3.3 G34R-Mutant Glioma: A Report of 3 Cases and Review of the Literature, PEDIATRIC NEUROSURGERY, 55(5), 319-325, 202012
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  283. Detecting non-germinomatous germ cell tumor component by arterial spin labeling perfusion-weighted MR imaging in central nervous system germ cell tumor, EUROPEAN JOURNAL OF RADIOLOGY, 136, 202103
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  284. T2-FLAIR Mismatch Sign and Response to Radiotherapy in Diffuse Intrinsic Pontine Glioma, PEDIATRIC NEUROSURGERY, 56(1), 1-9, 202103
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  285. ★, Phase I/II study of tirabrutinib, a second-generation Bruton's tyrosine kinase inhibitor, in relapsed/refractory primary central nervous system lymphoma, NEURO-ONCOLOGY, 23(1), 122-133, 20210101
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Publications such as books

  1. 2020/10/01, not mentioned, not mentioned, not mentioned, not mentioned, brain tumor, malignancy, not mentioned, 2020, 10, Scholarly Book, Supervisor, 日本語, 285, 285
    Amazon Image Link (Small)
  2. 2019/05/20, not mentioned, not mentioned, not mentioned, brain tumor, not mentioned, 2019, 5, Scholarly Book, Supervisor, 日本語, 199, 199
    Amazon Image Link (Small)
  3. 1996, Incidental meningiomas in computed tomography and magnetic resonance imaging era , Brain tumor research and therapy(Springer-Verlag), 1996
  4. 1996, Analysis of sdi-1 gene functions in human malignant glioma , Brain Tumor Research and Therapy, 1996
  5. 2000, Chroid Plexus tumor-choroid plexus papilloma and choroid plexus carcihoma- , 2000
  6. 2010/10, Brain Cancer. Brain tumors: Apparent diffusion coefficient at magnetic resonance imaging. , Elsvier= Amsterdam=Lausanne= New York= Oxford= Shannon= Tokyo, 2010, 10, Textbook, Compilation
  7. 2015/10/01, Epithelidoid/rhabdoid glioblastoma, 2015, 10, Scholarly Book, Joint work, 日本語, 2
  8. 2017/10/01, Color Atlas of Brain Tumort Pathology, 4th edition, Scholarly Book, Joint work, 日本語, 978-4-260-03047-2
  9. 2018/03/20, General Rules of Clinical and Pathological Studies on Brain Tumors, 4th editon, Scholarly Book, Joint work, 日本語, 978-4-307-20385-2

Invited Lecture, Oral Presentation, Poster Presentation

  1. General review of molecular targeting drugs for CNS malignancies, Sugiyama Kazuhiko, 40th annual meeting of The Japanese Congress of Neurological Surgeons, 2020/08/12, With Invitation, Japanese, The Japanese Congress of Neurological Surgeons, Kanazawa, Japan
  2. Standard Therapy adult patients with GBM & PCNSL, Sugiyama Kazuhiko, 57th annual meeting of Japanese Society of Clinical Oncology, 2019/10/26, With Invitation, Japanese, Japanese Society of Clinical Oncology, Fukuoka, Japan
  3. Future Perspectives of AYA Brain tumors, Sugiyama Kazuhiko, 57th annual meeting of Japanese Society of Clinical Oncology, 2019/10/25, With Invitation, Japanese, Japanese Society of Clinical Oncology, Fukuoka, Japan
  4. Long-term follow-up for CNS malignancies in childhood and AYA, Sugiyama Kkazuhiko, 2019/02/16, With Invitation, Japanese, Japanese Society of Clinical Oncology, Hiroshima, Japan
  5. Clinical guideline for CNS malignancies, Sugiyama Kazuhiko, Japanese Society of Clinical Oncology, 2018/10/20, With Invitation, Japanese, Japanese Society of Clinical Oncology, Yokohama, Japan
  6. Long-term outcomes and QOL of the patients with germinoma, 2nd Japan-Italy Symposium on AYA survivors with childhood cancers, 2015/01/10, With Invitation, English, Japan-Italy Symposium on AYA survivors with childhood cancers, Tokyo, Japan, QOL of the patients treated with 50-Gy RTX is much lower than that of the patients with low dose RTX+CMTX. The anterior pituitary functions progressed after 50-Gy RTX and the second tumors would have developed in higher rate. On the contrary, The anterior pituitary functions have preserved or improved after low dose RTX+CMTX, and the occurrence rate of the second tumors is very low.In actuarial KM analysis of OS and EFS, low dose RTX+CMTX is superior to 50-Gy radiation retrospectively, because of avoiding second tumors and other second events.The next aim is to evaluate QOL of the patients with NH-involved lesions.
  7. Brain Tumor: Consensus meeting on preserving fertility of patients with pediatric and adolescent cancer, Kazuhiko Sugiyama, Chikako Kiyotani, Yoko Miyoshi, Tasuro Hurui, Hiroyuki Hishiyama, 54th Annual meeting of Japan Society of Clinical Oncology, 2016/10/21, With Invitation, Japanese, Japan Society of Clinical Oncology, Yokohama, Japan, to establish the consensus on the way to preserve fertility of pediatric and adolescent patients with malignant brain tumor, other
  8. Dose-reduced radiotherapy with platinum-based chemotherapy has improved quality of life with the long-term survivors with germinoma, Kazuhiko Sugiyama, Fumiyuki Yamasaki, Kaoru Kurisu, Kazunori Arita, 21st International Conference on Brain Tumor Research and Therapy (ICBTRT2016), 2016/04/12, With Invitation, English, organizing committee of 21st International Conference on Brain Tumor Research and Therapy, Okinawa, Japan, This retrospective analysis in patients with germinoma indicated that volume-reduced radiotherapy concomitantly with chemotherapy improved overall survival and did not prolong event-free survival compared with 50-Gy radiotherapy. The protection of second events and the preservation of endocrine function, especially fertility should be mandated., published
  9. QOL of extremely long-time survivors with germinoma, Kazuhiko Sugiyama, 22nd international conference of brain tumors on research and therapy, 2018/06/24, With Invitation, English, organized committee of 22nd international conference of brain tumors on research and therapy, Bergen, Norway, The aims of this paper are to summarize outcomes of quality of life of the extremely long-time survivors with germinoma mainly treated with bilateral beams of radiation, and to compare them with those who treated with dose & volume-reduced chemo-radiotherapy. Radiation group consisted of 52 patients treated from 1968 to 1995 Median F/U was 240 months. Main causes of death included second tumors and several social events after care-givers’ death. Second tumors consisted of 5 high grade gliomas, 1 atypical meningioma, and 1 osteosarcoma. Hormonal impairments were worsened around one year after radiation treatment. Marriage & career status were also unsatisfactory. Dose & volume-reduced chemo-radiotherapy group consisted of 45 patients treated from 1999 to 2009. Median F/U was 171 months. All tumors completely disappeared after this treatment. All of them have been alive, while we have 5 second CR after initial recurrences. The peaks of growth hormone were generally well-preserved, or improved in some cases around one year after treatment. Chronic myeloid leukemia and parotid carcinoma within radiation field occurred 12 months and 48 months after treatment. In cause-specific OS, that means germinoma-related death rate, both groups were similar, but mainly radiation group was inferior to dose & volume-reduced group in actuarial OS. Evaluation of quality of life in dose & volume-reduced group is the next aim.

Social Activities

Organizing Academic Conferences, etc.

  1. 38th annual meeting of The Japan Society of Neuro-Oncology, President, 2020/11, 2020/12

History as Peer Reviews of Academic Papers

  1. 2015, International Journal of Clinical Oncology, Editor, editor, 5
  2. 2015, Brain Tumor Pathology, Editorial Member, 5
  3. 2015, Neuro-oncology, Others, reviewer, 3
  4. 2016, Neurologia Medico-chirurgica (Tokyo), Editor, reviewer, 6
  5. 2017, Brain Tumor Pathology, Editor, editor, 6
  6. 2018, International Journal of Clinical Oncology, Editor, editor, 5
  7. 2017, International Journal of Clinical Oncology, Editor, reviewer, 5
  8. 2016, International Journal of Clinical Oncology, Editor, Editor, 5
  9. 2017, Neurologia Medico-chirurgica (Tokyo), Editor, reviewer
  10. 2015, Neurologia Medico-chirurgica (Tokyo), Editor, reviewer, 5
  11. 2018, Neurologia Medico-chirurgica (Tokyo), Editor, reviewer, 5
  12. 2016, Brain Tumor Pathology, Editor, editor, 5
  13. 2018, Brain Tumor Pathology, Editor, editor, 5
  14. 2017, Neuro-Oncology Practice, Editor, reviewer, 3
  15. 2018, Neuro-Oncology Practice, Editor, reviewer, 3