Last Updated :2022/01/05

Affiliations, Positions
Hiroshima University Hospital(Medical), Associate Professor or Lecturer

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Endocrinology

Research Keywords

  • aldosterone
  • renin-angiotensin-aldosterone system
  • primary aldosteronism
  • endocrine hypertension
  • adrenal gland
  • cortisol

Affiliated Academic Societies

  • The Japan Society of Internal Medicine
  • The Japan Endocrine Society
  • The Japan Diabetes Society
  • The Japanese Society of Hypertension
  • Japan Hormonal Steroid Society
  • Endocrine Society

Educational Activity

Course in Charge

  1. 2021, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2021, Undergraduate Education, Intensive, Symptomatology, Diagnosis and Treatment
  3. 2021, Undergraduate Education, Intensive, Practice for medical research
  4. 2021, Undergraduate Education, Intensive, Practice of Medicine I
  5. 2021, Undergraduate Education, Intensive, Practice of Medicine II

Research Activities

Academic Papers

  1. Resistance to Thyroid Hormone Accompanied by Graves' Disease, INTERNAL MEDICINE, 50(18), 1977-1980, 2011
  2. Significantly high level of late-night free cortisol to creatinine ratio in urine specimen in patients with subclinical Cushing's syndrome, CLINICAL ENDOCRINOLOGY, 79(5), 617-622, 201311
  3. Minireview: Potassium Channels and Aldosterone Dysregulation: Is Primary Aldosteronism a Potassium Channelopathy?, ENDOCRINOLOGY, 155(1), 47-55, 201401
  4. ★, Effect of Aldosterone-Producing Adenoma on Endothelial Function and Rho-Associated Kinase Activity in Patients With Primary Aldosteronism, HYPERTENSION, 65(4), 841-+, 201504
  5. Japanese Lifestyle during Childhood Prevents the Future Development of Obesity among Japanese-Americans, PLOS ONE, 10(3), 20150325
  6. Activation of Classical Brown Adipocytes in the Adult Human Perirenal Depot Is Highly Correlated with PRDM16-EHMT1 Complex Expression, PLOS ONE, 10(3), 20150326
  7. A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma, INTERNAL MEDICINE, 54(18), 2355-2360, 2015
  8. A case of polyglandular autoimmune syndrome type III complicated with autoimmune hepatitis, ENDOCRINE JOURNAL, 53(5), 705-709, 2006
  9. Therapies for adrenal insufficiency, EXPERT OPINION ON PHARMACOTHERAPY, 8(9), 1283-1291, 2007
  10. Circulating visfatin level is correlated with inflammation, but not with insulin resistance, CLINICAL ENDOCRINOLOGY, 67(5), 796-800, 2007
  11. A case of Addison's disease confirmed with low dose cosyntropin stimulation test, ENDOCRINE JOURNAL, 54(5), 765-769, 2007
  12. Primary aldosteronism and hypercortisolism due to bilateral functioning adrenocortical adenomas, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 12(5), 382-387, 2008
  13. Combined acromegaly and subclinical Cushing disease related to high-molecular-weight adrenocorticotropic hormone, JOURNAL OF NEUROSURGERY, 110(2), 369-373, 2009
  14. Angiotensin II and III Metabolism and Effects on Steroid Production in the HAC15 Human Adrenocortical Cell Line, ENDOCRINOLOGY, 154(1), 214-221, 2013
  15. Potassium Channel Mutant KCNJ5 T158A Expression in HAC-15 Cells Increases Aldosterone Synthesis, ENDOCRINOLOGY, 153(4), 1774-1782, 2012
  16. Aldosterone synthase (CYP11B2) C-344T polymorphism affects the association of age-related changes of the serum C-reactive protein, HYPERTENSION RESEARCH, 33(4), 326-330, 2010
  17. Improvement of hypercortisolism by beta-blocker therapy in subclinical Cushing's syndrome associated with ACTH-independent macronodular adrenocortical hyperplasia, ENDOCRINE, 36(3), 372-376, 2009
  18. The single nucleotide polymorphism upstream of insulin-induced gene 2 (INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women, BRITISH JOURNAL OF NUTRITION, 101(3), 322-327, 2009
  19. The Potassium Channel, Kir3.4 Participates in Angiotensin II-Stimulated Aldosterone Production by a Human Adrenocortical Cell Line, ENDOCRINOLOGY, 153(9), 4328-4335, 2012
  20. Role of mineralocorticoid action in the brain in salt-sensitive hypertension, CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 39(1), 90-95, 2012
  21. Infective endocarditis and acute purulent pericarditis in a patient with hyperglycemia, INTERNAL MEDICINE, 44(6), 666-670, 2005
  22. Hypothalamic-pituitary-adrenal axis activity is associated with the prevalence of chronic kidney disease in diabetic patients, ENDOCRINE JOURNAL, 63(2), 119-126, 20160220
  23. ★, Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma, MEDICINE, 95(20), 201605
  24. ★, YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 434(C), 93-98, 20161015
  25. ★, Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma, HYPERTENSION, 68(6), 1432-1437, 201612
  26. Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 441(C), 124-133, 20170205
  27. Westernization of lifestyle affects quantitative and qualitative changes in adiponectin, CARDIOVASCULAR DIABETOLOGY, 16, 20170706
  28. Ampulla cardiomyopathy associated with adrenal insufficiency and hypothyroidism., Int J Cardiol, 108(3), 391-392
  29. NFIA co-localizes with PPAR gamma and transcriptionally controls the brown fat gene program, NATURE CELL BIOLOGY, 19(9), 1081-+, SEP 2017
  30. Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model, JOURNAL OF GASTROENTEROLOGY, 52(11), 1180-1191, NOV 2017
  31. ★, Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma, HYPERTENSION, 71(1), 125-133, 201801
  32. Association between Serum Elaidic Acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 24(12), 1206-1214, 2017
  33. Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 461(C), 100-104, 201802
  34. ★, Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 103(3), 965-971, 201803
  35. Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism, HYPERTENSION RESEARCH, 41(11), 932-938, 201811
  36. Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels, STEROIDS, 140, 179-184, 201812
  37. Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 185, 137-141, 201901
  38. Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study, JOURNAL OF HYPERTENSION, 37(5), 1083-1095, 201905
  39. Associations of nutrient intakes with obesity and diabetes mellitus in the longitudinal medical surveys of Japanese Americans, JOURNAL OF DIABETES INVESTIGATION, 10(5), 1229-1236, 201909
  40. Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men, JOURNAL OF DIABETES INVESTIGATION, 10(6), 1463-1470, 201911
  41. Elevated Plasma Renin Activity Caused by Accelerated-malignant Hypertension in a Patient with Aldosterone-producing Adenoma Complicated with Renal Insufficiency, INTERNAL MEDICINE, 58(21), 3107-3111, 201911
  42. ★, Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75(2), 492-499, 202002
  43. A Case of Isolated Adrenocorticotropic Hormone Deficiency Caused by Pembrolizumab, CASE REPORTS IN ONCOLOGY, 13(1), 200-206, 202003
  44. A Comparison of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 105(11), 202011
  45. ★, The landscape of molecular mechanism for aldosterone production in aldosterone-producing adenoma, ENDOCRINE JOURNAL, 67(10), 989-995, 2020
  46. Variation in plasma glucagon levels according to obesity status in Japanese Americans with normal glucose tolerance, ENDOCRINE JOURNAL, 68(1), 95-102, 2021
  47. Sex Differences in Renal Outcomes After Medical Treatment for Bilateral Primary Aldosteronism, HYPERTENSION, 77(2), 537-545, 202102
  48. ★, Update on Genetics of Primary Aldosteronism, BIOMEDICINES, 9(4), 202104
  49. Should Adrenal Venous Sampling Be Performed in PA Patients Without Apparent Adrenal Tumors?, FRONTIERS IN ENDOCRINOLOGY, 12, 20210412
  50. Association of aldosterone and blood pressure with the risk for cardiovascular events after treatments in primary aldosteronism, ATHEROSCLEROSIS, 324, 84-90, 202105
  51. ★, Aldosterone-Producing Adenomas More Than Meets the Eye, HYPERTENSION, 75(4), 927-929, 202004
  52. Renal Injuries in Primary Aldosteronism: Quantitative Histopathological Analysis of 19 Patients With Primary Adosteronism, HYPERTENSION, 78(2), 411-421, 202108
  53. Angiotensin-converting enzyme 2 expression is not induced by the renin-angiotensin system in the lung, ERJ Open Research, 6(4), 00402-2020, 20201005
  54. Angiotensin-converting enzyme 2 expression is not induced by the renin-angiotensin system in the lung., ERJ Open Research, 6(4), 00402-2020-00402-2020, 202010


  1. 2020/07/20, Japan Endocrine Society Research Award, Japan Endocrine Society
  2. 2019/10/14, Excellent Presentation Award, Progress in Primary Aldosteronisum 6, ER chaperone calmegin is upregulated in aldosterone-producing adeno-ma and associates with aldosterone production
  3. 2013/04/28, Best Young Investigator Award, International Symposium of Aldosterone and Related Substances in Hypertension (ISARSH)2013
  4. 2012/06/22, 38th Annual Meeting of the International Aldosterone Conference, Young Investigator Award, 38th Annual Meeting of the International Aldosterone Conference