Basic Information
Academic Degrees
- Doctor of Philosophy in Medical Science, Hiroshima University
Research Fields
- Medicine,dentistry, and pharmacy;Clinical internal medicine;Endocrinology
Research Keywords
- aldosterone
- renin-angiotensin-aldosterone system
- primary aldosteronism
- endocrine hypertension
- adrenal gland
- cortisol
Affiliated Academic Societies
- The Japan Society of Internal Medicine
- The Japan Endocrine Society
- The Japan Diabetes Society
- The Japanese Society of Hypertension
- Japan Hormonal Steroid Society
- Endocrine Society
Educational Activity
Course in Charge
- 2022, Undergraduate Education, Year, Clinical diagnosis and treatment I
- 2022, Undergraduate Education, Intensive, Symptomatology, Diagnosis and Treatment
- 2022, Undergraduate Education, Intensive, Practice for medical research
- 2022, Undergraduate Education, Intensive, Practice of Medicine I
- 2022, Undergraduate Education, Intensive, Practice of Medicine II
Research Activities
Academic Papers
- Association of cardiovascular disease risk and changes in renin levels by mineralocorticoid receptor antagonists in patients with primary aldosteronism, HYPERTENSION RESEARCH, 45(9), 1476-1485, 202209
- ★,
Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma
, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 548, 20220515 - Resistance to Thyroid Hormone Accompanied by Graves' Disease, INTERNAL MEDICINE, 50(18), 1977-1980, 2011
- Significantly high level of late-night free cortisol to creatinine ratio in urine specimen in patients with subclinical Cushing's syndrome, CLINICAL ENDOCRINOLOGY, 79(5), 617-622, 201311
- Minireview: Potassium Channels and Aldosterone Dysregulation: Is Primary Aldosteronism a Potassium Channelopathy?, ENDOCRINOLOGY, 155(1), 47-55, 201401
- ★, Effect of Aldosterone-Producing Adenoma on Endothelial Function and Rho-Associated Kinase Activity in Patients With Primary Aldosteronism, HYPERTENSION, 65(4), 841-+, 201504
- Japanese Lifestyle during Childhood Prevents the Future Development of Obesity among Japanese-Americans, PLOS ONE, 10(3), 20150325
- Activation of Classical Brown Adipocytes in the Adult Human Perirenal Depot Is Highly Correlated with PRDM16-EHMT1 Complex Expression, PLOS ONE, 10(3), 20150326
- A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma, INTERNAL MEDICINE, 54(18), 2355-2360, 2015
- A case of polyglandular autoimmune syndrome type III complicated with autoimmune hepatitis, ENDOCRINE JOURNAL, 53(5), 705-709, 2006
- Therapies for adrenal insufficiency, EXPERT OPINION ON PHARMACOTHERAPY, 8(9), 1283-1291, 2007
- Circulating visfatin level is correlated with inflammation, but not with insulin resistance, CLINICAL ENDOCRINOLOGY, 67(5), 796-800, 2007
- A case of Addison's disease confirmed with low dose cosyntropin stimulation test, ENDOCRINE JOURNAL, 54(5), 765-769, 2007
- Primary aldosteronism and hypercortisolism due to bilateral functioning adrenocortical adenomas, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 12(5), 382-387, 2008
- Combined acromegaly and subclinical Cushing disease related to high-molecular-weight adrenocorticotropic hormone, JOURNAL OF NEUROSURGERY, 110(2), 369-373, 2009
- Angiotensin II and III Metabolism and Effects on Steroid Production in the HAC15 Human Adrenocortical Cell Line, ENDOCRINOLOGY, 154(1), 214-221, 2013
- Potassium Channel Mutant KCNJ5 T158A Expression in HAC-15 Cells Increases Aldosterone Synthesis, ENDOCRINOLOGY, 153(4), 1774-1782, 2012
- Aldosterone synthase (CYP11B2) C-344T polymorphism affects the association of age-related changes of the serum C-reactive protein, HYPERTENSION RESEARCH, 33(4), 326-330, 2010
- Improvement of hypercortisolism by beta-blocker therapy in subclinical Cushing's syndrome associated with ACTH-independent macronodular adrenocortical hyperplasia, ENDOCRINE, 36(3), 372-376, 2009
- The single nucleotide polymorphism upstream of insulin-induced gene 2 (INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women, BRITISH JOURNAL OF NUTRITION, 101(3), 322-327, 2009
- The Potassium Channel, Kir3.4 Participates in Angiotensin II-Stimulated Aldosterone Production by a Human Adrenocortical Cell Line, ENDOCRINOLOGY, 153(9), 4328-4335, 2012
- Role of mineralocorticoid action in the brain in salt-sensitive hypertension, CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 39(1), 90-95, 2012
- Infective endocarditis and acute purulent pericarditis in a patient with hyperglycemia, INTERNAL MEDICINE, 44(6), 666-670, 2005
- Hypothalamic-pituitary-adrenal axis activity is associated with the prevalence of chronic kidney disease in diabetic patients, ENDOCRINE JOURNAL, 63(2), 119-126, 20160220
- ★, Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma, MEDICINE, 95(20), 201605
- ★, YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 434(C), 93-98, 20161015
- ★, Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma, HYPERTENSION, 68(6), 1432-1437, 201612
- Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 441(C), 124-133, 20170205
- Westernization of lifestyle affects quantitative and qualitative changes in adiponectin, CARDIOVASCULAR DIABETOLOGY, 16, 20170706
- Ampulla cardiomyopathy associated with adrenal insufficiency and hypothyroidism., Int J Cardiol, 108(3), 391-392
- NFIA co-localizes with PPAR gamma and transcriptionally controls the brown fat gene program, NATURE CELL BIOLOGY, 19(9), 1081-+, 201709
- Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model, JOURNAL OF GASTROENTEROLOGY, 52(11), 1180-1191, 201711
- ★, Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma, HYPERTENSION, 71(1), 125-133, 201801
- Association between Serum Elaidic Acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 24(12), 1206-1214, 2017
- Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 461(C), 100-104, 201802
- ★, Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 103(3), 965-971, 201803
- Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism, HYPERTENSION RESEARCH, 41(11), 932-938, 201811
- Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels, STEROIDS, 140, 179-184, 201812
- Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 185, 137-141, 201901
- Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study, JOURNAL OF HYPERTENSION, 37(5), 1083-1095, 201905
- Associations of nutrient intakes with obesity and diabetes mellitus in the longitudinal medical surveys of Japanese Americans, JOURNAL OF DIABETES INVESTIGATION, 10(5), 1229-1236, 201909
- Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men, JOURNAL OF DIABETES INVESTIGATION, 10(6), 1463-1470, 201911
- Elevated Plasma Renin Activity Caused by Accelerated-malignant Hypertension in a Patient with Aldosterone-producing Adenoma Complicated with Renal Insufficiency, INTERNAL MEDICINE, 58(21), 3107-3111, 201911
- ★, Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75(2), 492-499, 202002
- A Case of Isolated Adrenocorticotropic Hormone Deficiency Caused by Pembrolizumab, CASE REPORTS IN ONCOLOGY, 13(1), 200-206, 202003
- A Comparison of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 105(11), 202011
- ★, The landscape of molecular mechanism for aldosterone production in aldosterone-producing adenoma, ENDOCRINE JOURNAL, 67(10), 989-995, 2020
- Variation in plasma glucagon levels according to obesity status in Japanese Americans with normal glucose tolerance, ENDOCRINE JOURNAL, 68(1), 95-102, 2021
- Sex Differences in Renal Outcomes After Medical Treatment for Bilateral Primary Aldosteronism, HYPERTENSION, 77(2), 537-545, 202102
- ★, Update on Genetics of Primary Aldosteronism, BIOMEDICINES, 9(4), 202104
- Should Adrenal Venous Sampling Be Performed in PA Patients Without Apparent Adrenal Tumors?, FRONTIERS IN ENDOCRINOLOGY, 12, 20210412
- Association of aldosterone and blood pressure with the risk for cardiovascular events after treatments in primary aldosteronism, ATHEROSCLEROSIS, 324, 84-90, 202105
- ★, Aldosterone-Producing Adenomas More Than Meets the Eye, HYPERTENSION, 75(4), 927-929, 202004
- Renal Injuries in Primary Aldosteronism: Quantitative Histopathological Analysis of 19 Patients With Primary Adosteronism, HYPERTENSION, 78(2), 411-421, 202108
- Angiotensin-converting enzyme 2 expression is not induced by the renin-angiotensin system in the lung, ERJ Open Research, 6(4), 00402-2020, 20201005
- Angiotensin-converting enzyme 2 expression is not induced by the renin-angiotensin system in the lung., ERJ Open Research, 6(4), 00402-2020-00402-2020, 202010
- ★, Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 538, 20211201
- Subtype-specific trends in the clinical picture of primary aldosteronism over a 13-year period, JOURNAL OF HYPERTENSION, 39(11), 2325-2332, 202111
- ★, ATP1A1
Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation
, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(20), 202110 - Familial Hyperaldosteronism Type 3 with a Rapidly Growing Adrenal Tumor: An In Situ Aldosterone Imaging Study, CURRENT ISSUES IN MOLECULAR BIOLOGY, 44(1), 128-138, 202201
Awards
- 2020/07/20, Japan Endocrine Society Research Award, Japan Endocrine Society
- 2019/10/14, Excellent Presentation Award, Progress in Primary Aldosteronisum 6, ER chaperone calmegin is upregulated in aldosterone-producing adeno-ma and associates with aldosterone production
- 2013/04/28, Best Young Investigator Award, International Symposium of Aldosterone and Related Substances in Hypertension (ISARSH)2013
- 2012/06/22, 38th Annual Meeting of the International Aldosterone Conference, Young Investigator Award, 38th Annual Meeting of the International Aldosterone Conference