HIROSHI KAWAGUCHI

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor
E-mail
hrkawahiroshima-u.ac.jp
Other Contact Details
1-2-3 KASUMI MINAMI-KU HIROSHIMA, Japan
TEL : (+81)82-257-5212 FAX : (+81)82-257-5214
Self-introduction
My profession: Pediatric oncology, support for childhood cancer survivors, adolescent and young adult cancer patients and educational support for high school patients

Basic Information

Major Professional Backgrounds

  • 2003/04/16, 2008/09/30, Hiroshima University, Hospital, Assisant doctor
  • 2007/04/01, 2009/05/17, Hiroshima University, Hospital, Assisant doctor
  • 2009/05/18, 2010/12/05, Higashihiroshima Medical Center, Hospital, Medical Staff
  • 2010/12/06, 2020/06/30, Hiroshima University, Hospital, Lecturer
  • 2020/07/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Associate Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Field of Clinical Medical Science, Japan, 1999/04, 2003/03
  • Hiroshima University, Faculty of Medicine, Field of Medicine, Japan, 1986/04, 1992/03

Academic Degrees

  • Medical Doctor, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Pediatrics

Research Keywords

  • Stem cell transplantation
  • Neutropenia
  • Solid tumor
  • Hematology
  • Oncology

Affiliated Academic Societies

  • Japan pediatric society, 1992
  • Japan pediatric hematology oncology society, 1993
  • Japan pediatric allergy society, 2000
  • Japan hematology society, 2000
  • Japan infectious disease society, 2011
  • Japan stemcell transplantation society, 2011

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  2. 2024, Undergraduate Education, Intensive, Practice of Medicine II
  3. 2024, Graduate Education (Master's Program) , Second Semester, General Clinical Medicine and Dentistry

Research Activities

Academic Papers

  1. Age-specific incidence of joint disease in paediatric patients with haemophilia: A single-centre real-world outcome based on consecutive US examination, HAEMOPHILIA, 29(5), 1359-1365, 202309
    Link to Paper Search Results by DOI
  2. Clinical significance of human neutrophil antigen-1 antibodies in children with neutropenia, INTERNATIONAL JOURNAL OF HEMATOLOGY, 118(5), 627-635, 202311
    Link to Paper Search Results by DOI
  3. A complementary approach for genetic diagnosis of inborn errors of immunity using proteogenomic analysis, PNAS NEXUS, 2(4), 20230403
    Link to Paper Search Results by DOI
  4. Outcome of hematopoietic stem cell transplantation in pediatric patients with acute lymphoblastic leukemia not in remission enrolled in JACLS ALL-02, INTERNATIONAL JOURNAL OF HEMATOLOGY, 118(3), 364-373, 202309
    Link to Paper Search Results by DOI
  5. Pirarubicin Combination Low-Dose Chemotherapy for Early Infantile Stage MS Neuroblastoma: Case Report, CHILDREN-BASEL, 10(5), 20230512
    Link to Paper Search Results by DOI
  6. Graft-versus-host disease-free, relapse-free, second transplant-free survival in allogeneic hematopoietic cell transplantation for genetic disorders, Bone Marrow Transplant, 58(5), 600-602, 202305
  7. BRAF V600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis, Haematologica, 107(7), 1719-1725, 202207
  8. Recombinant human soluble thrombomodulin and danaparoid combination anticoagulant therapy for disseminated intravascular coagulation in a child with streptococcal toxic shock syndrome: A case report, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 24(6), 202212
    Link to Paper Search Results by DOI
  9. Hematopoietic Cell Transplantation for Inborn Errors of Immunity Other than Severe Combined Immunodeficiency in Japan: Retrospective Analysis for 1985-2016, JOURNAL OF CLINICAL IMMUNOLOGY, 42(3), 529-545, 202204
    Link to Paper Search Results by DOI
  10. Bone marrow transplantation from a human leukocyte antigen-mismatched unrelated donor in a case with C1q deficiency associated with refractory systemic lupus erythematosus, INTERNATIONAL JOURNAL OF HEMATOLOGY, 113(2), 302-307, 202102
    Link to Paper Search Results by DOI
  11. Possible involvement of regulatory T cell abnormalities and variational usage of TCR repertoire in children with autoimmune neutropenia, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 204(1), 1-13, 2021
    Link to Paper Search Results by DOI
  12. Downregulation of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) in a co-culture system with human stimulated X-linked CGD neutrophils, PLOS ONE, 15(4), 20200406
    Link to Paper Search Results by DOI
  13. Clinical course of autologous recovery with chromosomal abnormalities after allogeneic hematopoietic stem cell transplantation, BONE MARROW TRANSPLANTATION, 55(6), 1023-1028, 202006
    Link to Paper Search Results by DOI
  14. Conditioning regimen for allogeneic bone marrow transplantation in children with acquired bone marrow failure: fludarabine/melphalan vs. fludarabine/cyclophosphamide, BONE MARROW TRANSPLANTATION, 55(7), 1272-1281, 202007
    Link to Paper Search Results by DOI
  15. Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusion-dependent pyruvate kinase deficiency anemia, HEMATOLOGY REPORTS, 12(1), 2020
    Link to Paper Search Results by DOI
  16. Simultaneous detection of ABL1 mutation and IKZF1 deletion in Philadelphia chromosome-positive acute lymphoblastic leukemia using a customized target enrichment system panel, INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 40(4), 427-436, 201808
    Link to Paper Search Results by DOI
  17. Intensification of induction therapy and prolongation of maintenance therapy did not improve the outcome of pediatric Langerhans cell histiocytosis with single-system multifocal bone lesions: results of the Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study, INTERNATIONAL JOURNAL OF HEMATOLOGY, 108(2), 192-198, 201808
    Link to Paper Search Results by DOI
  18. Secondary bone/soft tissue sarcoma in childhood cancer survivors: a nationwide hospital-based case-series study in Japan, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 48(9), 806-814, 201809
    Link to Paper Search Results by DOI
  19. Secondary cancer after a childhood cancer diagnosis: viewpoints considering primary cancer., Int J Clin Oncol, 2018
    Link to Paper Search Results by DOI
  20. Development of cystic malacia after high-dose cranial irradiation of pediatric CNS tumors in long-term follow-up, CHILDS NERVOUS SYSTEM, 33(6), 957-964, 2017
    Link to Paper Search Results by DOI
  21. Cavernous angioma after chemotherapy for desmoplastic/nodular medulloblastoma associated with anhidrotic ectodermal dysplasia, Childs nervous system, 32(2), 395-398, 2016
    Link to Paper Search Results by DOI
  22. Secondary cancers after a childhood cancer diagnosis: a nationwide hospital-based retrospective cohort study in Japan., International journal of clinical oncology, 2016
    Link to Paper Search Results by DOI
  23. Early eradication of factor VIII inhibitor in patients with congenital hemophilia A by immune tolerance induction with a high dose of immunoglobulin., International journal of hematology, 103(4), 2016
    Link to Paper Search Results by DOI
  24. Intensified and prolonged therapy comprising cytarabine, vincristine and prednisolone improves outcome in patients with multisystem Langerhans cell histiocytosis: results of the Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study., International journal of hematology, 2016
    Link to Paper Search Results by DOI
  25. Effective Treatment of a Childhood Blastic Plasmacytoid Dendritic Cell Neoplasm with a Cutaneous Tumor Alone by Stem Cell Transplantation with Reduced Intensity Conditioning, INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 32, S26-S31, 201606
    Link to Paper Search Results by DOI
  26. A Comparison of Myelopoiesis from Induced Pluripotent Stem Cells with a Mutation in ELANE between Cyclic Neutropenia and Severe Congenital Neutropenia, BLOOD, 126(23), 2015
  27. Early elimination of Factor VIII inhibitor by ITI with high dose immunoglobulin in children with hemophilia A, HAEMOPHILIA, 20, 46-46, 2014
  28. Excessive Nitric Oxide Production of CGD Neutrophils Induces the Down-Regulation of NOS3 and EDN1 Expression in Human Endothelial Cells, BLOOD, 124(21), 2014
  29. Successful Retransplantation of Bone Marrow Cells Following Failure of Initial Engraftment in 4 Patients with SCN, BLOOD, 124(21), 2014
  30. Heterozygosity for the Y701C STAT1 mutation in a multiplex kindred with multifocal osteomyelitis, Haematologica, 98(10), 1641-1649, 201310
    Link to Paper Search Results by DOI
  31. Central nervous system complications and neuroradiological findings in children with chronic active EpsteinBarr virus infection, PEDIATRICS INTERNATIONAL, 55(1), 72-78, 2013
  32. Continuous intravenous infusion of ketamine and lidocaine as adjuvant analgesics in a 5-year-old patient with neuropathic cancer pain., J Palliat Med, 15(6), 719-22, 20120601
  33. Clinical and Genetic Characteristics of Patients with Severe Congenital Neutropenia in Japan, BLOOD, 118(21), 1387-1388, 2011
  34. Autoimmune neutropenia due to antineutrophil antibodies in a patient with primary sclerosing cholangitis., Clinical journal of gastroenterology, 3(3), 2010
  35. [Hepatic arterial infusion of liposomal amphotericin B for multiple fungal abscesses in the liver of a patient with chronic granulomatous disease]., [Rinshō ketsueki] The Japanese journal of clinical hematology, 51(5), 2010
  36. Successful treatment of Kasabach-Merritt syndrome with vincristine and diagnosis of the hemangioma using three-dimensional imaging., Pediatric Hematology and Oncology, 26(5), 375-80, 20090701
  37. Respiratory complications after haematopoietic stem cell transplantation in a patient with chronic granulomatous disease., Transfusion Medicine, 19(2), 105-8, 20090401
  38. Effective Hematopoietic Stem Cell Transplantation with Reduced Intensity Conditioning for Patients with Chronic Granulomatous Disease, BLOOD, 114(22), 1296-1296, 2009
  39. Neurodevelopmental abnormalities associated with severe congenital neutropenia due to the R86X mutation in the HAX1 gene., J. Med. Genet., 45(12), 802-807, 20081201
  40. Reconstitution of Regulatory T Cells Involves in the Development of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation., BLOOD, 112(11), 769-769, 2008
  41. The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-gamma receptor 1 and has a dominant-negative effect on interferon-gamma signal transduction., J Med Genet, 44(8), 485-491, 20070801
  42. A novel mutation 774del4 in IFNGR1, which produces truncated form of interferon gamma receptor 1, causes a dominant-negative effect on interferon gamma signal transduction., Blood, 108(11), 367A-367A, 2006
  43. ★, A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia., Haematologica, 90, 1032-41, 20050401
  44. ★, Dysregulation of transcriptions in primary granule constituents during myeloid proliferation and differentiation in patients with severe congenital neutropenia, Journal of Leukocyte Biology, 73, 225-234, 20030401
  45. Efficacy of the prophylactic use of trimethoprim-sulfamethoxazole in auotimmune neutropenia in infancy, Pediatric Hematology and Oncology, 25, 553-557, 20030401
  46. Defects of granulopoiesis in patients with severe congenital neutropenia, Hiroshima Journal of Medical Sciences, 51, 63-74, 20020401
  47. ★, Significance of the detection of antineutrophil antibodies in children with chronic neutropenia, Blood, 99, 3468-3471, 20020401
  48. Defects of granulopoiesis in patients with severe congenital neutropenia., Hiroshima journal of medical sciences, 51(3), 2002
  49. Significance of the eosinophilic cationic protein/eosinophil count ratio in asthmatic patients:its relationship to disease severity, Ann. Allergy Asthma Immunol, 86, 323-329, 20010401
  50. ★, Abnormalities of primitive myeloid progenitor cells expresssing granulocyte colony-stimulating factor receptor in patients with severe congenital neutropenia, Blood, 96, 4366-4369, 20000401
  51. Plasma brain natriuretic peptide concentrations in patients with Kawasaki disease, Pediatr Int, 42, 241-248, 20000401
  52. A case of congenital nasal pyriform aperture stenosis, Pediatr Int, 41, 327-328, 19990401
  53. Superior mesenteric artery syndrome complicating mitochondrial encephalopathy, J. Pediatr. Gastroenterol. Nutr., 26, 464-467, 19980401
  54. Bone marrow suppression inducedby high dose valproic acid, Arch. Dis. Child., 71, 153-155, 19940401

Invited Lecture, Oral Presentation, Poster Presentation

  1. Hematopoietic stem cell transplantation for inborn errors of immunity in Japan: overview of a nationwide retrospective analysis, Satoshi Miyamoto, Masakatsu Yanagimachi, Katsutsugu Umeda, Akihiro Iguchi, Yoji Sasahara, Hidetoshi Takada, Masafumi Yamada, Masataka Ishimura ,Takashi Koike, Masahiro Yasui, Yoshiyuki Takahashi, Hiroshi Kawaguchi, Michiko Kajiwara, Masami Inoue, Koji Kato, Yoshiko Hashii, Yoshiko Atsuta, Hiromasa Yabe, Tomohiro Morio, Kohsuke Imai, EBMT, 2020/08/30, Without Invitation, English
  2. Pharmacokinetics of Extended Half-Life Factor VIII Products By myPKFiTR Is Useful for Personalized Treatment in Children with Severe Hemophilia a., Matsumura Risa, Nishimura Shiho, Mizoguchi Yoko, Kawaguchi Hiroshi, Kobayashi Masao, 2019/12/09, Without Invitation, English
  3. Outcome of Hematopoietic Stem Cell Transplantation in the Patients with Pediatric Acute Lymphoblastic Leukemia Enrolled in the Japan Association of Childhood Leukemia Study (JACLS) ALL-02., Yano Mio, Ishida Hisashi, Hara Junichi, Kawaguchi Hiroshi, Ito Etsuro, Saito Akiko, Sato Atsushi, Hori Hiroki, Horibe Keizo, Imamura Toshihiko, 2019/12/09, Without Invitation, English
  4. Successful Bone Marrow Transplantation Using an Immunomyelosuppressive Conditioning in Patients with Severe Congenital Neutropenia: The Results of a Single-Institute., Matsumura Risa, Nishimura Shiho, Mizoguchi Yoko, Kawaguchi Hiroshi, Kobayashi Masao, 2019/12/09, Without Invitation, English
  5. Atypical clinical presentation of leukemia developing in severe congenital neutropenia: A case report, Morishita Yusuke, Mochizuki Shinji, Matsumura Risa, Hayakawa Hiroko, Ashihara Kosuke, Maruyama Natsuki, Doi Takehiko, Hyakuna Nobuyuki, Kawaguchi Hiroshi, Kobayashi Masao, 2019/11/14, Without Invitation, Japanese
  6. BRAFV600E-POSITIVE PRECURSORS AS MOLECULAR MARKERS OF BONE MARROW INVOLVEMENT IN PEDIATRIC LANGERHANS CELL HISTIOCYTOSIS, Kudo Ko, Kanezaki Rika, Imamura Masaru, Imai Chihaya, Irie Masahiro, Sasahara Yoji, Ando Kumiko, Kakuda Harumi, Doi Takehiko, Kawaguchi Hiroshi, Kudo Kazuko, Kanegane Hirokazu, Kobayashi Akie, Sato Tomohiko, Kamio Takuya, Sasaki Shinya, Terui Kiminori, Toki Tsutomu, Ito Etsuro, 2019/11/14, Without Invitation, Japanese
  7. A Neonatal Systemic Juvenile Xanthogranuloma Presented With Vanishing Bile Duct Syndrome, Shimomura, Maiko; Doi, Takehiko; Taniguchi, Maki; Ohno, Ayaka; Karakawa, Shuhei; Okada, Satoshi; Kawaguchi, Hiroshi, 2019/11/14, Without Invitation, Japanese
  8. Congenital Neutropenia Caused by SRP54 Mutations, Suzawa, Ayaka; Krakawa, Shuhei; Okada, Satoshi; Saito, Satoshi; Nishimura, Shiho; Kobayashi, Yoshiyuki; Mizoguchi, Yoko; Doi, Takehiko; Kawaguchi, Hiroshi; Imai, Chihaya; Ohara, Osamu; Kobayashi, Masao, 2019/11/14, Without Invitation, Japanese
  9. Two Cases of Hepatoblastoma With A Parental History of Familial Adenomatous Polyposis, Taniguchi, Maki; Karakawa, Shuhei; Suzawa, Ayaka; Chogahara, Kumi; Ohno, Ayaka; Shimomura, Maiko; Kurihara, Sho; Ueda, Yuka; Hiyama, Eiso; Kawaguchi, Hiroshi, 2019/11/14, Without Invitation, Japanese
  10. Conditioning Regimen for Allogeneic Bone Marrow Transplantation in Children With Acquired Bone Marrow Failure: Fludarabine/Melphalan vs. Fludarabine/Cyclophosphamide, Yoshida, Nao; Takahashi, Yoshiyuki; Yabe, Hiromasa; Kobayashi, Ryoji; Watanabe, Kenichiro; Kudo, Kazuko; Yabe, Miharu; Miyamura, Takako; Koh, Katsuyoshi; Kawaguchi, Hiroshi; Goto, Hiroaki; Fujita, Naoto; Hara, Junichi; Okamoto, Yasuhiro; Kato, Koji; Inoue, Masami; Suzuki, Ritsuro; Atsuta, Yoshiko; Kojima, Seiji, 2019/11/14, Without Invitation, Japanese
  11. Secondary Cancer After a Childhood Cancer Diagnosis: Viewpoints Considering Primary Cancer, Ishida, Y ; Maeda, M ; Adachi, S ; Inada, H ; Kawaguchi, H ; Hori, H ; Ogawa, A ; Kudo, K ; Kiyotani, C ; Shichino, H ; Rikiishi, T ; Kobayashi, R ; Sato, M ; Okamura, J ; Goto, H ; Manabe, A ; Yoshinaga, S ; Qiu, D ; Fujimoto, J ; Kuroda, T, SIOP, 2018/11/17, Without Invitation, English
  12. C-Reactive Protein and Bone Pain at Diagnosis Predict the Outcome of Pediatric Langerhans Cell Histiocytosis with Single-System Multifocal Lesions: Result of The Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study, 2017/10/03, Without Invitation, English
  13. Langerhans cell histiocytosis: Case presentation, 2016/12/15, Without Invitation, English
  14. Successful bone marrow tranaslantation in ten patients with SCN, 2016/10/13, Without Invitation, Japanese
  15. SUCCESSFUL HEMATOPOIETIC STEM CELL TRANSPLANTATION IN TEN PATIENTS WITH SEVERE CONGENITAL NEUTROPENIA USING AN INTENSIVE IMMUNOMYELOSUPPRESSIVE CONDITIONING REGIMEN: THE RESULTS OF A SINGLE INSTITUTE, 2016/06/09, Without Invitation, English
  16. A Comparison of Myelopoiesis from Induced Pluripotent Stem Cells with a Mutation in ELANE between Cyclic Neutropenia and Severe Congenital Neutropenia, 2015/12/03, Without Invitation, Japanese

Social Activities

History as Peer Reviews of Academic Papers

  1. 2015, Pediatric international, reviewer, 1
  2. 2014, Pediatric international, reviewer, 2