Takeshi Yamazaki

Last Updated :2023/09/06

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
takeyhiroshima-u.ac.jp

Basic Information

Educational Backgrounds

  • Tokyo Institute of Technology, Graduate School, Division of Science and Engineering, Japan, 1981/04, 1986/03
  • Tokyo Institute of Technology, Faculty of Science, Japan, 1977/04, 1981/03

Academic Degrees

  • Ph.D., Tokyo Institute of Technology
  • Master of Sciences, Tokyo Institute of Technology

Educational Activity

  • [Bachelor Degree Program] School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences : Integrated Arts and Sciences
  • [Master's Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
  • [Master's Program] Graduate School of Advanced Science and Engineering : Division of Advanced Science and Engineering : Transdisciplinary Science and Engineering Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
  • [Doctoral Program] Graduate School of Advanced Science and Engineering : Division of Advanced Science and Engineering : Transdisciplinary Science and Engineering Program
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

In Charge of Primary Major Programs

  • Integrated Arts and Sciences

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Complex systems;Brain sciences;Brain biometrics

Research Keywords

  • steroid hormone
  • Adrenal gland
  • brain
  • estradiol
  • neurosteroid
  • neuroprotection

Affiliated Academic Societies

  • The Japanese Biochemical Society
  • The Japan Neuroscience Society
  • The Japan Endocrine Society
  • Japan Hormonal Steroid Society
  • Society for Neuroscience

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 2Term, General Chemistry
  2. 2023, Undergraduate Education, Second Semester, Laboratory Work in Natural Sciences
  3. 2023, Undergraduate Education, Second Semester, Practical Methods in Natural Sciences
  4. 2023, Undergraduate Education, 3Term, Functional Biochemistry II
  5. 2023, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  6. 2023, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  7. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Life and Environmental Sciences
  8. 2023, Graduate Education (Master's Program) , First Semester, Exercises in Life and Environmental Sciences A
  9. 2023, Graduate Education (Master's Program) , Second Semester, Exercises in Life and Environmental Sciences B
  10. 2023, Graduate Education (Master's Program) , 1Term, Introduction to Integrated Arts and Sciences
  11. 2023, Graduate Education (Master's Program) , Second Semester, Functional biochemistry
  12. 2023, Graduate Education (Doctoral Program) , First Semester, Seminar in Integrated Arts and Scirnces II
  13. 2023, Graduate Education (Doctoral Program) , 4Term, Exercises in Integrated Life Sciences
  14. 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  15. 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  16. 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  17. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  18. 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  19. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  20. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure, JOURNAL OF NEUROINFLAMMATION, 19(1), 20220729
    Link to Paper Search Results by DOI
  2. Kiss1-dependent and independent release of luteinizing hormone and testosterone in perinatal male rats, ENDOCRINE JOURNAL, 69(7), 797-807, 2022
    Link to Paper Search Results by DOI
  3. Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1866(2), 2021
    Link to Paper Search Results by DOI
  4. Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1868(3), 2021
    Link to Paper Search Results by DOI
  5. DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(6), 2021
    Link to Paper Search Results by DOI
  6. FosL1 Is a Novel Target of Levetiracetam for Suppressing the Microglial Inflammatory Reaction, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(20), 202110
    Link to Paper Search Results by DOI
  7. Microbial Degradation of Fenitrothion in Kurose River Water, Hiroshima Prefecture, Japan, Research Journal of Environmental Sciences, 14(141), 5-517, 20200517
    Link to Paper Search Results by DOI
  8. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: a comparative study of levetiracetam, valproate and carbamazepine., Neuroscience Letter, 708, 134363, 20190824
  9. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis., J Steroid Biochem Mol Biol., 193, 105421, 201910
  10. ★, Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus., Scientific Report, 9(1), 13899, 20190925
  11. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine, NEUROSCIENCE LETTERS, 708, 20190824
    Link to Paper Search Results by DOI
  12. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus, SCIENTIFIC REPORTS, 9, 20190925
    Link to Paper Search Results by DOI
  13. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 193, 201910
    Link to Paper Search Results by DOI
  14. Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 496(2), 582-587, 20180205
    Link to Paper Search Results by DOI
  15. Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids, COMMUNICATIONS BIOLOGY, 1, 2018
    Link to Paper Search Results by DOI
  16. Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells, Scientific Reports, 7, 20170202
    Link to Paper Search Results by DOI
  17. A single cell level measurement of StAR expression and activity in adrenal cells, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 441(C), 22-30, 20170205
    Link to Paper Search Results by DOI
  18. ★, Potentiation of 17beta-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid., Scientific Reports, 7, 6268, 2017
  19. Potentiation of 17 beta-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid, SCIENTIFIC REPORTS, 7, 20170724
    Link to Paper Search Results by DOI
  20. Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 477(4), 820-825, 20160902
    Link to Paper Search Results by DOI
  21. Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures, STEROIDS, 113, 71-77, 201609
    Link to Paper Search Results by DOI
  22. Regulation of StAR by the N-terminal Domain and Coinduction of SIK1 and TIS11b/Znf36I1 in Single Cells, FRONTIERS IN ENDOCRINOLOGY, 7, 20160802
    Link to Paper Search Results by DOI
  23. Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(3), 182-190, 20161101
    Link to Paper Search Results by DOI
  24. Transcription factor activation in rat primary astrocytes exposed to methylmercury., Fundam. Toxicol. Sci., 3, 63-65, 2016
  25. Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 201501
    Link to Paper Search Results by DOI
  26. Protective Actions of 17 beta-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015
    Link to Paper Search Results by DOI
  27. Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression, MOLECULAR CANCER, 14, 20150419
    Link to Paper Search Results by DOI
  28. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 201507
    Link to Paper Search Results by DOI
  29. Estradiol rapidly modulates synaptic plasticity of hippocampal neurons: Involvement of kinase networks, BRAIN RESEARCH, 1621, 147-161, 20150924
    Link to Paper Search Results by DOI
  30. Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia OXIDATIVE STRESS TOLERANCE AND CONVERGENCE OF INFLAMMATORY RESPONSES, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(37), 22805-22817, 20150911
    Link to Paper Search Results by DOI
  31. Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 20140318
    Link to Paper Search Results by DOI
  32. Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1, NATURE COMMUNICATIONS, 5, 201404
    Link to Paper Search Results by DOI
  33. Stimulation of estradiol biosynthesis by tributyltin in rat hippocampal slices, ENDOCRINE RESEARCH, 39(4), 168-172, 2014
    Link to Paper Search Results by DOI
  34. Angiotensin II and III Metabolism and Effects on Steroid Production in the HAC15 Human Adrenocortical Cell Line, ENDOCRINOLOGY, 154(1), 214-221, 201301
    Link to Paper Search Results by DOI
  35. De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 20130206
    Link to Paper Search Results by DOI
  36. Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 135, 1-6, 201305
    Link to Paper Search Results by DOI
  37. An Active C-Terminally Truncated Form of Ca2+/Calmodulin-Dependent Protein Kinase Phosphatase-N (CaMKP-N/PPM1E), BIOMED RESEARCH INTERNATIONAL, 2013
    Link to Paper Search Results by DOI
  38. Non-Sex Cord-Stromal Ovarian Tumors Frequently Produce and Secrete Estrogen in Postmenopausal Women: Impact on Bone Metabolism and Abnormal Endometrial Histology, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 98(7), 2775-2782, 201307
    Link to Paper Search Results by DOI
  39. Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: Noninvasive measurement of the brain redox state by magnetic resonance imaging, FREE RADICAL RESEARCH, 47(9), 731-739, 201309
    Link to Paper Search Results by DOI
  40. Bisphenol A significantly modulates long-term depression in the hippocampus as observed by multi-electrode system, NEUROENDOCRINOLOGY LETTERS, 34(2), 129-134, 2013
    Link to Paper Search Results by DOI
  41. Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures, NEUROCHEMISTRY INTERNATIONAL, 60(8), 782-790, 201206
    Link to Paper Search Results by DOI
  42. A sensitive method based on fluorescence-detected circular dichroism for protein local structure analysis, ANALYTICAL BIOCHEMISTRY, 430(2), 179-184, 20121115
    Link to Paper Search Results by DOI
  43. Endogenous Synthesis of Corticosteroids in the Hippocampus, PLOS ONE, 6(7), 20110728
    Link to Paper Search Results by DOI
  44. Environmental enrichment alters gene expression of steroidogenic enzymes in the rat hippocampus, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 171(1), 28-32, 20110301
    Link to Paper Search Results by DOI
  45. Sex hormone synthesis and synaptocrinology in rat hippocampal synapses, NEUROSCIENCE RESEARCH, 71, E264-E264, 2011
  46. Evaluation of neurotoxicity of trimethyltin in rat brain under various housing conditions, NEUROSCIENCE RESEARCH, 71, E340-E340, 2011
  47. Adrenocortical Zonation in Humans under Normal and Pathological Conditions, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 95(5), 2296-2305, 201005
    Link to Paper Search Results by DOI
  48. ★, Social isolation stimulates hippocampal estradiol synthesis, Bichem. Biophys. Res. Commun, 379, 480-484, 20090201
  49. Social isolation stimulates hippocampal estradiol syntheses, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 379(2), 480-484, 20090206
    Link to Paper Search Results by DOI
  50. Retinoic Acid Stimulates 17 beta-Estradiol and Testosterone Synthesis in Rat Hippocampal Slice Cultures, ENDOCRINOLOGY, 150(9), 4260-4269, 200909
    Link to Paper Search Results by DOI
  51. ENVIRONMENTAL ENRICHMENT INCREASES MRNA CONTENTS OF ALLOPREGNANOLONE SYNTHETIC ENZYMES, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 293-293, 2009
  52. Neuroprotective effect of estradiol on methylmercury-induced neuronal cell toxicity in rat hippocampal slices, NEUROSCIENCE RESEARCH, 65, S220-S220, 2009
  53. Diurnal expression of neurosteroidogenic enzymes mRNA in the rat hippocampus, NEUROSCIENCE RESEARCH, 65, S221-S221, 2009
  54. Effect of direct injection of tributyltin on estradiol synthesis in rat hippocampus, NEUROSCIENCE RESEARCH, 61, S186-S186, 2008
  55. Social isolation increases mRNA contents of estradiol synthetic enzymes, NEUROSCIENCE RESEARCH, 61, S187-S187, 2008
  56. Allosteric inhibition of rat neuronal nitric-oxide synthase caused by interference with the binding of calmodulin to the enzyme, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(2), 231-240, 200702
    Link to Paper Search Results by DOI
  57. Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons, JOURNAL OF NEUROCHEMISTRY, 100(4), 950-967, 200702
    Link to Paper Search Results by DOI
  58. Dephosphorylation of TORC initiates expression of the StAR gene, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 265, 196-204, 200702
    Link to Paper Search Results by DOI
  59. Topological study of membrane proteins by mass spectrometry, J. Mass Spectrom. Soc. Jpn., 55(3), 221, 20070601
  60. Effect of retinoic acid on neurosteroidogenesis in cultured rat hippocampus, NEUROSCIENCE RESEARCH, 58, S75-S75, 2007
  61. Ca2+ signal stimulates the expression of steroidogenic acute regulatory protein and steroidogenesis in bovine adrenal fasciculata-reticularis cells, Life Sci., 78, 2923-2930, 20060401
  62. Comparison between basal and apical dendritic spines in estrogen-induced rapid spinogenesis of CA1 principal neurons in the adult hippocampus., Biochem. Biophys. Res. Commun., 351(2), 553-558, 20060401
  63. The interaction of cytochrome P450 17.alpha. with NADPH-cytochrome P450 reductase, investigated using chemical modification and MALDI-TOF mass spectrometry., Biochimica et Biophysica Acta, 1764(6), 1126-1131, 20060601
  64. Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein, Biochimica et Biophysica Acta, 1764(10), 1561-1567, 20061001
  65. Ca2+ signal stimulates the expression of steroidogenic acute regulatory protein and steroidogenesis in bovine adrenal fasciculata-reticularis cells, LIFE SCIENCES, 78(25), 2923-2930, 20060515
    Link to Paper Search Results by DOI
  66. Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1764(10), 1561-1567, 200610
    Link to Paper Search Results by DOI
  67. Comparison between basal and apical dendritic spines in estrogen-induced rapid spinogenesis of CA1 principal neurons in the adult hippocampus, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 351(2), 553-558, 20061215
    Link to Paper Search Results by DOI
  68. Molecular mechanism of activation of estrogen biosynthesis by tributyltin in rat hippocampus, NEUROSCIENCE RESEARCH, 55, S162-S162, 2006
  69. The interaction of cytochrome P450 17 alpha with NADPH-cytochrome P450 reductase, investigated using chemical modification and MALDI-TOF mass spectrometry, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1764(6), 1126-1131, 2006
  70. Tributyltin disturbs bovine adrenal steroidogenesis by two modes of action., steroids, 70(14), 913-921, 20051215
  71. Mechanism of inhibition of cytochrome P450C21 enzyme activity by autoantibodies from patients with Addison's disease, EUROPEAN JOURNAL OF ENDOCRINOLOGY, 152(1), 95-101, 200501
    Link to Paper Search Results by DOI
  72. Distributions of steroid 5 alpha-reductase and 17 alpha-hydroxylase/C17,20-lyase (P450c17) immunoreactivities in rat gastric mucosa, ACTA HISTOCHEMICA ET CYTOCHEMICA, 38(1), 61-67, 2005
    Link to Paper Search Results by DOI
  73. Tributyltin disturbs bovine adrenal steroidogenesis by two modes of action, STEROIDS, 70(14), 913-921, 20051215
    Link to Paper Search Results by DOI
  74. Photodegradation kinetics of fenitrothion in various aqueous media and its effect on steroid hormones biosynthesis, Geochem. J., 38, 201-213, 20040401
  75. Inhibitory effect of organotin compounds on rat neuronal nitric oxide synthase through interaction with calmodulin, Biochem. Biophys. Res. Comm., 324, 178-185, 20040401
  76. Photodegradation kinetics of fenitrothion in various aqueous media and its effect on steroid hormone biosynthesis, Geochim. Cosmochim. Acta, 67, A78, 20030401
  77. Corticosterone enhances adrenocorticotropin-induced calcium signals in bovine adrenocortical cells, Endocrinology, 144, 3376-3381, 20030401
  78. Corticosterone enhances adrenocorticotropin-induced calcium signals in bovine adrenocortical cells, ENDOCRINOLOGY, 144(8), 3376-3381, 200308
    Link to Paper Search Results by DOI
  79. Membrane topology of guinea pig cytochrome P450 17 alpha revealed by a combination of chemical modifications and mass spectrometry, BIOCHEMISTRY, 42(49), 14663-14669, 20031216
    Link to Paper Search Results by DOI
  80. Two mode of regulation mecahnism in the succssive reaction of rat neuronal nitric oxide synthase, International Congress Series, 1129, 157-162, 20020401
  81. Membrane reconstitution of recombinant guinea pig cytochrome P45017 alpha and the effects of site-directed mutagenesis on androgen formation, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 81(3), 255-262, 200207
    Link to Paper Search Results by DOI
  82. Tributyltin perturbs adrenal steroid hormone biosynthesis., Environ. Sci., 8, 126, 20010401
  83. Regulation of the Successive Reaction Catalyzed by Rat Neuronal Nitric Oxide Synthase The Rate-determining Step in P450 C21-catalyzing Reactions in a Membrane-reconstituted System, J. Biol. Chem., 276, 10753-10758, 20010401
  84. The rate-determining step in P450 C21-catalyzing reactions in a membrane-reconstituted system, J Biol Chem, 276(14), 10753-10758, 20010406
  85. The rate-determining step in P450C21-catalyzing reactions in a membrane-reconstituted system, JOURNAL OF BIOLOGICAL CHEMISTRY, 276(14), 10753-10758, 20010406
    Link to Paper Search Results by DOI
  86. Regulation of the successive reaction catalyzed by rat neuronal nitric oxide synthase, BIOCHEMISTRY, 39(49), 15150-15155, 20001212
    Link to Paper Search Results by DOI
  87. Pregnenolone, pregnenolone sulfate, and cytochrome P450 side-chain cleavage enzyme in the amphibian brain and their seasonal changes, Endocrinology, 140, 1936-1944, 19990401
  88. EPR studies on the photo-induced intermediates of ferric NO complexes on rat neuronal nitric oxide synthase trapped at low temperature, J. Biochem., 126, 756-761, 19990401
  89. Kinetic Studies on the Successive Reaction of Neuronal Nitric Oxide Synthase from L-Arginine to Nitric Oxide and L-Citrulline, Bio chemistry, 38, 16629-16635, 19990401
  90. Calcium ion as a second messenger for o-nitrophenylsulfenyl-adrenocorticotropin (NPS-ACTH) and ACTH in bovine adrenal steroidogenesis, Endocrinology, 139, 4765-4771, 19980401
  91. Successive reactions catalyzed by cytochromes P450, Keio J. Med., 45, S57, 19960401
  92. 15-Lipoxygenase metabolite(s) of arachidonic acid mediates adrenocorticotropin action in bovine adrenal steroidogenesis, Endocrinology, 137, 2670-2675, 19960401
  93. Molecular mechanism of cytochrome P-450 dependent aldosterone biosynthesis in the adrenal cortex, Trend in Endocri. Metabolism, 6, 267-273, 19950401
  94. Metabolism of exogenous cholesterol by rat adrenal mitochondria is stimulated equally by physiological levels of free Ca2+ and by GTP, Mol. Cell. Endocrinol., 107, 181-188, 19950401
  95. P450scc-dependent cholesterol metabolism in rat adrenal mitochondria is inhibited by low concentrations, Arch. Biochem. Biophys., 318, 131-139, 19950401
  96. Avian Neurosteroids: (I) Pregnenolone biosynthesis in the quail brain of matrix Ca2+, Brain Res., 678, 19950401
  97. Avian Neurosteroids: (II) Localization o a cytochrome P450scc-like substance in the quail brain, Brain Res., 678, 1020, 19950401
  98. Potential of Soil and Sediment for the reduction of nitrous oxide, Soil Phys. Cond. Plant Growth= Jpn., 65, 21-28, 19920401
  99. Regulation of cholesterol movement to mitochondrial cytochrome P450scc in steroid hormone synthesis, J. Steroid Biochem. Mol. Biol., 43, 751-767, 19920401
  100. Kinetic studies on androstendione production in ovarian microsomes from immature rats, Biochim. Biophys. Acta, 1125, 335-340, 19920401
  101. Thiobacillus novellus cytochrome c oxidase contains one heme a molecule and one copper atom per catalytic unit, J. Biochem., 111, 46-53, 19920401
  102. Cytochrome P-460 of Nitrosomonas europaea: Further purification and further characterization, J. Biochem., 108, 1016-1021, 19900401
  103. Some properties of Nitrosomonas europaea cytochrome c oxidase (aa3-type) which lacks CuA, J. Biochem., 105, 245-248, 19890401
  104. Catalytic properties of cytochrome c oxidase purified from Nitrosomonas europaea, J. Biochem., 103, 499-503, 19880401
  105. The variety of molecular properties of bacterial cytochromes containing heme a, Ann. New York Acad. Sci., 550, 39-46, 19880401
  106. Purification and some properties of cytochrome b-560 from Nitrosomonas europaea, Plant Cell Physiol., 29, 1077-1079, 19880401
  107. N2O reduction by Azotobacter vinelandii with emphasis on kinetic nitrogen isotope effect, Plant Cell Physiol., 28, 263-271, 19870401
  108. Effects of phospholipid and detergent on bacterial cytochrome c oxidase, Biol. Chem. Hoppe-Seyler, 367, 344, 19860401
  109. Cytochrome a1 of Nitrosomonas europaea resembles aa3-type cytochrome c oxidase in many respects, Biochim. Biophys. Acta, 810, 174-183, 19860401
  110. A comparative survey of sevral bacterial aa3-type cytochrome c oxidase, J. Inorg. Biochem., 23, 273-277, 19850401

Publications such as books

  1. 2014, Neurosteroids: regional steroidogenesis. In Fifty Years of Cytochrome P450 Research., Springer, 2014
  2. 2010/04, Organophosphates as endocrine disruptors In: T. Satoh, R.C. Gupta (ed.) Anticholinesterase Pesticides, John Wiley ＆ Sons Ltd., 2010, 04, Scholarly Book, Joint work
  3. 2008/03, Delving into the Source of Knowledge (Liberal Arts in the 21st Century) , 2008, 03, Textbook, Compilation, 9784563019044, 260
  4. 1998, Kinetic analysis of successive reactions catalyzed by cytochromes P45017α, lyase and P45011β(共著) , Oxygen Homeostasis and its Dynamics Springer-Verlag, 1998
  5. 1997, P450scc activity in the brain(共著) , Perspectives in Avian Endocrinology Journal of Endocrinology Ltd. = Bristol, 1997
  6. 1995, Neurosteroids in the avian brain , Environmental Impact on Endocrine System in Vertebrates (ed. B. K. Follett= M. M. Aruldhas and S. K. Maitra), 1995, Scholarly Book, Cocompilation, 15
  7. 1993, Cytochrome P-450-linked electeron transport system in monooxygenase , Cytochrome P-450(Kodansha Scientific), 1993, Scholarly Book, Cocompilation, 9
  8. 1992, Control mechanism of P-45011β dependent catalytic activity in bovine adrenal mitochondria , Biotechnological and Ecological Aspects (ed. A.I.Archakov) Taylor and Francis Inc., 1992, Scholarly Book, Cocompilation, 5

Invited Lecture, Oral Presentation, Poster Presentation

  1. A novel toxic target for methylmercury in mouse brain, T. Yamazaki, T. Namba, R. Takahashi, K. Itoh, M. Yamamoto, Y. Ishihara, A. Oguro, 2020, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2020, 2022
  2. 2019
  3. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2019
  4. 2017, 2019
  5. KAKENHI, 2013, 2015
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  6. KAKENHI, 2013, 2015
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  7. 2012, 2014
  8. KAKENHI, Protective effect of neurosteroids on developmental brains, 2010, 2012
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  9. KAKENHI, Method for Pin-Point Structure Analysis of Proteins by Fluorescence-Detected CD, 2010, 2012
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  10. 2009, 2010
  11. KAKENHI, Sensitive assay for disturbance of brain function by environmental pollutants at low concentrations, 2006, 2007
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  12. 2002, 2003
  13. KAKENHI, 2002, 2003
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  14. KAKENHI, 2001, 2001
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  15. KAKENHI, 1999, 1999
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  16. KAKENHI, 1998, 1998
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  17. KAKENHI, A new reaction scheme of steroidogenic membrane enzymes and its physiological meanings., 1997, 1998
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  18. KAKENHI, 1997, 1997
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  19. KAKENHI, 1996, 1996
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  20. KAKENHI, BIOSYNTHESIS AND ACTION OF NEUROSTEROIDS IN THE BRAIN, 1996, 1997
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  21. KAKENHI, 1994, 1994
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  22. KAKENHI, 1993, 1993
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  23. KAKENHI, Molecular mechanism of aldosterone biosynthesis, 1993, 1994
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  24. KAKENHI, A large scale expression of cytochrome P-450XVIIA1 and studeies on the reaction mechanism using membrane reconstituted sysrems., 1993, 1994
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Social Activities

Organizing Academic Conferences, etc.

  1. 2020/.7

History as Peer Reviews of Academic Papers

  1. 2020, Neuroendcrinology, Editor, 12