Takeshi Yamazaki

Last Updated :2021/07/08

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
takeyhiroshima-u.ac.jp

Basic Information

Educational Backgrounds

  • Tokyo Institute of Technology, Graduate School, Division of Science and Engineering, Japan, 1981/04, 1986/03
  • Tokyo Institute of Technology, Faculty of Science, Japan, 1977/04, 1981/03

Academic Degrees

  • Ph.D., Tokyo Institute of Technology
  • Master of Sciences, Tokyo Institute of Technology

Educational Activity

  • 【Bachelor Degree Program】School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences
  • 【Master's Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • 【Master's Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • 【Doctoral Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • 【Doctoral Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

In Charge of Primary Major Programs

  • Integrated Arts and Sciences

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Complex systems;Brain sciences;Brain biometrics

Research Keywords

  • steroid hormone
  • Adrenal gland
  • brain
  • estradiol
  • neurosteroid
  • neuroprotection

Affiliated Academic Societies

  • The Japanese Biochemical Society
  • The Japan Neuroscience Society
  • The Japan Endocrine Society
  • Japan Hormonal Steroid Society
  • Society for Neuroscience

Educational Activity

Course in Charge

  1. 2021, Liberal Arts Education Program1, 2Term, General Chemistry
  2. 2021, Undergraduate Education, Second Semester, Laboratory Work in Natural Sciences
  3. 2021, Undergraduate Education, Second Semester, Practical Methods in Natural Sciences
  4. 2021, Undergraduate Education, 4Term, ethicsIn science
  5. 2021, Undergraduate Education, 2Term, Introduction to Life Sciences
  6. 2021, Undergraduate Education, 3Term, Functional Biochemistry II
  7. 2021, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  8. 2021, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  9. 2021, Undergraduate Education, 4Term, Functional Biochemistry III
  10. 2021, Undergraduate Education, 1Term, Fundamentals of Biochemistry I
  11. 2021, Undergraduate Education, 2Term, Fundamentals of Biochemistry II
  12. 2021, Graduate Education (Master's Program) , 1Term, Special Lectures in Integrated Sciences for Life
  13. 2021, Graduate Education (Master's Program) , First Semester, Overseas Academic Activities
  14. 2021, Graduate Education (Master's Program) , Second Semester, Overseas Academic Activities
  15. 2021, Graduate Education (Master's Program) , First Semester, Science Seminar (A)
  16. 2021, Graduate Education (Master's Program) , Second Semester, Science Seminar (A)
  17. 2021, Graduate Education (Doctoral Program) , Year, Academic research overseas
  18. 2021, Graduate Education (Doctoral Program) , Year, Long-term Internship for Integrated Sciences for Life
  19. 2021, Graduate Education (Doctoral Program) , First Semester, Science Seminar B
  20. 2021, Graduate Education (Doctoral Program) , Second Semester, Science Seminar B
  21. 2021, Graduate Education (Master's Program) , 2Term, Seminar in Integrated Arts and Sciences I
  22. 2021, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Life and Environmental Sciences
  23. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Life and Environmental Sciences A
  24. 2021, Graduate Education (Master's Program) , 2Term, Exercises in Life and Environmental Sciences A
  25. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Life and Environmental Sciences B
  26. 2021, Graduate Education (Master's Program) , 4Term, Exercises in Life and Environmental Sciences B
  27. 2021, Graduate Education (Master's Program) , 1Term, Introduction to Integrated Arts and Sciences
  28. 2021, Graduate Education (Master's Program) , Second Semester, Functional biochemistry
  29. 2021, Graduate Education (Master's Program) , 2Term, Fundamental Seminar in Integrated Arts and Sciences
  30. 2021, Graduate Education (Doctoral Program) , 2Term, Seminar in Integrated Arts and Scirnces II
  31. 2021, Graduate Education (Doctoral Program) , 4Term, Exercises in Integrated Life Sciences
  32. 2021, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  33. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  34. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  35. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  36. 2021, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  37. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  38. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: a comparative study of levetiracetam, valproate and carbamazepine., Neuroscience Letter, 708, 134363, 20190824
  2. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis., J Steroid Biochem Mol Biol., 193, 105421, 201910
  3. ★, Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus., Scientific Report, 9(1), 13899, 20190925
  4. Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 496(2), 582-587, 20180205
  5. Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids, COMMUNICATIONS BIOLOGY, 1, 2018
  6. Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells, Scientific Reports, 7, 20170202
  7. A single cell level measurement of StAR expression and activity in adrenal cells, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 441(C), 22-30, 20170205
  8. ★, Potentiation of 17beta-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid., Scientific Reports, 7, 6268, 2017
  9. Potentiation of 17 beta-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid, SCIENTIFIC REPORTS, 7, 20170724
  10. Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 477(4), 820-825, 20160902
  11. Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures, STEROIDS, 113, 71-77, 201609
  12. Regulation of StAR by the N-terminal Domain and Coinduction of SIK1 and TIS11b/Znf36I1 in Single Cells, FRONTIERS IN ENDOCRINOLOGY, 7, 20160802
  13. Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(3), 182-190, 20161101
  14. Transcription factor activation in rat primary astrocytes exposed to methylmercury., Fundam. Toxicol. Sci., 3, 63-65, 2016
  15. Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 201501
  16. Protective Actions of 17 beta-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015
  17. Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression, MOLECULAR CANCER, 14, 20150419
  18. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 201507
  19. Estradiol rapidly modulates synaptic plasticity of hippocampal neurons: Involvement of kinase networks, BRAIN RESEARCH, 1621, 147-161, 20150924
  20. Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia OXIDATIVE STRESS TOLERANCE AND CONVERGENCE OF INFLAMMATORY RESPONSES, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(37), 22805-22817, 20150911
  21. Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 20140318
  22. Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1, NATURE COMMUNICATIONS, 5, 201404
  23. Stimulation of estradiol biosynthesis by tributyltin in rat hippocampal slices, ENDOCRINE RESEARCH, 39(4), 168-172, 2014
  24. Angiotensin II and III Metabolism and Effects on Steroid Production in the HAC15 Human Adrenocortical Cell Line, ENDOCRINOLOGY, 154(1), 214-221, 201301
  25. De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 20130206
  26. Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 135, 1-6, 201305
  27. An Active C-Terminally Truncated Form of Ca2+/Calmodulin-Dependent Protein Kinase Phosphatase-N (CaMKP-N/PPM1E), BIOMED RESEARCH INTERNATIONAL, 2013
  28. Non-Sex Cord-Stromal Ovarian Tumors Frequently Produce and Secrete Estrogen in Postmenopausal Women: Impact on Bone Metabolism and Abnormal Endometrial Histology, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 98(7), 2775-2782, 201307
  29. Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: Noninvasive measurement of the brain redox state by magnetic resonance imaging, FREE RADICAL RESEARCH, 47(9), 731-739, 201309
  30. Bisphenol A significantly modulates long-term depression in the hippocampus as observed by multi-electrode system, NEUROENDOCRINOLOGY LETTERS, 34(2), 129-134, 2013
  31. Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures, NEUROCHEMISTRY INTERNATIONAL, 60(8), 782-790, 201206
  32. A sensitive method based on fluorescence-detected circular dichroism for protein local structure analysis, ANALYTICAL BIOCHEMISTRY, 430(2), 179-184, 20121115
  33. Environmental enrichment alters gene expression of steroidogenic enzymes in the rat hippocampus, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 171(1), 28-32, 20110301
  34. Endogenous Synthesis of Corticosteroids in the Hippocampus, PLOS ONE, 6(7), 20110728
  35. Sex hormone synthesis and synaptocrinology in rat hippocampal synapses, NEUROSCIENCE RESEARCH, 71, E264-E264, 2011
  36. Evaluation of neurotoxicity of trimethyltin in rat brain under various housing conditions, NEUROSCIENCE RESEARCH, 71, E340-E340, 2011
  37. Adrenocortical Zonation in Humans under Normal and Pathological Conditions, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 95(5), 2296-2305, 201005
  38. Social isolation stimulates hippocampal estradiol syntheses, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 379(2), 480-484, 20090206
  39. ★, Social isolation stimulates hippocampal estradiol synthesis, Bichem. Biophys. Res. Commun, 379, 480-484, 20090201
  40. Retinoic Acid Stimulates 17 beta-Estradiol and Testosterone Synthesis in Rat Hippocampal Slice Cultures, ENDOCRINOLOGY, 150(9), 4260-4269, 200909
  41. ENVIRONMENTAL ENRICHMENT INCREASES MRNA CONTENTS OF ALLOPREGNANOLONE SYNTHETIC ENZYMES, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 293-293, 2009
  42. Neuroprotective effect of estradiol on methylmercury-induced neuronal cell toxicity in rat hippocampal slices, NEUROSCIENCE RESEARCH, 65, S220-S220, 2009
  43. Diurnal expression of neurosteroidogenic enzymes mRNA in the rat hippocampus, NEUROSCIENCE RESEARCH, 65, S221-S221, 2009
  44. Effect of direct injection of tributyltin on estradiol synthesis in rat hippocampus, NEUROSCIENCE RESEARCH, 61, S186-S186, 2008
  45. Social isolation increases mRNA contents of estradiol synthetic enzymes, NEUROSCIENCE RESEARCH, 61, S187-S187, 2008
  46. Topological study of membrane proteins by mass spectrometry, J. Mass Spectrom. Soc. Jpn., 55(3), 221, 20070601
  47. Allosteric inhibition of rat neuronal nitric-oxide synthase caused by interference with the binding of calmodulin to the enzyme, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(2), 231-240, 200702
  48. Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons, JOURNAL OF NEUROCHEMISTRY, 100(4), 950-967, 200702
  49. Dephosphorylation of TORC initiates expression of the StAR gene, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 265, 196-204, 200702
  50. Effect of retinoic acid on neurosteroidogenesis in cultured rat hippocampus, NEUROSCIENCE RESEARCH, 58, S75-S75, 2007
  51. Ca2+ signal stimulates the expression of steroidogenic acute regulatory protein and steroidogenesis in bovine adrenal fasciculata-reticularis cells, LIFE SCIENCES, 78(25), 2923-2930, 20060515
  52. Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1764(10), 1561-1567, 200610
  53. Comparison between basal and apical dendritic spines in estrogen-induced rapid spinogenesis of CA1 principal neurons in the adult hippocampus, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 351(2), 553-558, 20061215
  54. Ca2+ signal stimulates the expression of steroidogenic acute regulatory protein and steroidogenesis in bovine adrenal fasciculata-reticularis cells, Life Sci., 78, 2923-2930, 20060401
  55. Comparison between basal and apical dendritic spines in estrogen-induced rapid spinogenesis of CA1 principal neurons in the adult hippocampus., Biochem. Biophys. Res. Commun., 351(2), 553-558, 20060401
  56. The interaction of cytochrome P450 17.alpha. with NADPH-cytochrome P450 reductase, investigated using chemical modification and MALDI-TOF mass spectrometry., Biochimica et Biophysica Acta, 1764(6), 1126-1131, 20060601
  57. Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein, Biochimica et Biophysica Acta, 1764(10), 1561-1567, 20061001
  58. Molecular mechanism of activation of estrogen biosynthesis by tributyltin in rat hippocampus, NEUROSCIENCE RESEARCH, 55, S162-S162, 2006
  59. The interaction of cytochrome P450 17 alpha with NADPH-cytochrome P450 reductase, investigated using chemical modification and MALDI-TOF mass spectrometry, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1764(6), 1126-1131, 2006
  60. Tributyltin disturbs bovine adrenal steroidogenesis by two modes of action., steroids, 70(14), 913-921, 20051215
  61. Mechanism of inhibition of cytochrome P450C21 enzyme activity by autoantibodies from patients with Addison's disease, EUROPEAN JOURNAL OF ENDOCRINOLOGY, 152(1), 95-101, 200501
  62. Distributions of steroid 5 alpha-reductase and 17 alpha-hydroxylase/C17,20-lyase (P450c17) immunoreactivities in rat gastric mucosa, ACTA HISTOCHEMICA ET CYTOCHEMICA, 38(1), 61-67, 2005
  63. Tributyltin disturbs bovine adrenal steroidogenesis by two modes of action, STEROIDS, 70(14), 913-921, 20051215
  64. Photodegradation kinetics of fenitrothion in various aqueous media and its effect on steroid hormones biosynthesis, Geochem. J., 38, 201-213, 20040401
  65. Inhibitory effect of organotin compounds on rat neuronal nitric oxide synthase through interaction with calmodulin, Biochem. Biophys. Res. Comm., 324, 178-185, 20040401
  66. Corticosterone enhances adrenocorticotropin-induced calcium signals in bovine adrenocortical cells, ENDOCRINOLOGY, 144(8), 3376-3381, 200308
  67. Membrane topology of guinea pig cytochrome P450 17 alpha revealed by a combination of chemical modifications and mass spectrometry, BIOCHEMISTRY, 42(49), 14663-14669, 20031216
  68. Photodegradation kinetics of fenitrothion in various aqueous media and its effect on steroid hormone biosynthesis, Geochim. Cosmochim. Acta, 67, A78, 20030401
  69. Corticosterone enhances adrenocorticotropin-induced calcium signals in bovine adrenocortical cells, Endocrinology, 144, 3376-3381, 20030401
  70. Two mode of regulation mecahnism in the succssive reaction of rat neuronal nitric oxide synthase, International Congress Series, 1129, 157-162, 20020401
  71. Membrane reconstitution of recombinant guinea pig cytochrome P45017 alpha and the effects of site-directed mutagenesis on androgen formation, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 81(3), 255-262, 200207
  72. Tributyltin perturbs adrenal steroid hormone biosynthesis., Environ. Sci., 8, 126, 20010401
  73. Regulation of the Successive Reaction Catalyzed by Rat Neuronal Nitric Oxide Synthase The Rate-determining Step in P450 C21-catalyzing Reactions in a Membrane-reconstituted System, J. Biol. Chem., 276, 10753-10758, 20010401
  74. The rate-determining step in P450C21-catalyzing reactions in a membrane-reconstituted system, JOURNAL OF BIOLOGICAL CHEMISTRY, 276(14), 10753-10758, 20010406
  75. The rate-determining step in P450 C21-catalyzing reactions in a membrane-reconstituted system, J Biol Chem, 276(14), 10753-10758, 20010406
  76. Regulation of the successive reaction catalyzed by rat neuronal nitric oxide synthase, BIOCHEMISTRY, 39(49), 15150-15155, 20001212
  77. Pregnenolone, pregnenolone sulfate, and cytochrome P450 side-chain cleavage enzyme in the amphibian brain and their seasonal changes, Endocrinology, 140, 1936-1944, 19990401
  78. EPR studies on the photo-induced intermediates of ferric NO complexes on rat neuronal nitric oxide synthase trapped at low temperature, J. Biochem., 126, 756-761, 19990401
  79. Kinetic Studies on the Successive Reaction of Neuronal Nitric Oxide Synthase from L-Arginine to Nitric Oxide and L-Citrulline, Bio chemistry, 38, 16629-16635, 19990401
  80. Calcium ion as a second messenger for o-nitrophenylsulfenyl-adrenocorticotropin (NPS-ACTH) and ACTH in bovine adrenal steroidogenesis, Endocrinology, 139, 4765-4771, 19980401
  81. Successive reactions catalyzed by cytochromes P450, Keio J. Med., 45, S57, 19960401
  82. 15-Lipoxygenase metabolite(s) of arachidonic acid mediates adrenocorticotropin action in bovine adrenal steroidogenesis, Endocrinology, 137, 2670-2675, 19960401
  83. Molecular mechanism of cytochrome P-450 dependent aldosterone biosynthesis in the adrenal cortex, Trend in Endocri. Metabolism, 6, 267-273, 19950401
  84. Metabolism of exogenous cholesterol by rat adrenal mitochondria is stimulated equally by physiological levels of free Ca2+ and by GTP, Mol. Cell. Endocrinol., 107, 181-188, 19950401
  85. P450scc-dependent cholesterol metabolism in rat adrenal mitochondria is inhibited by low concentrations, Arch. Biochem. Biophys., 318, 131-139, 19950401
  86. Avian Neurosteroids: (I) Pregnenolone biosynthesis in the quail brain of matrix Ca2+, Brain Res., 678, 19950401
  87. Avian Neurosteroids: (II) Localization o a cytochrome P450scc-like substance in the quail brain, Brain Res., 678, 1020, 19950401
  88. Potential of Soil and Sediment for the reduction of nitrous oxide, Soil Phys. Cond. Plant Growth= Jpn., 65, 21-28, 19920401
  89. Regulation of cholesterol movement to mitochondrial cytochrome P450scc in steroid hormone synthesis, J. Steroid Biochem. Mol. Biol., 43, 751-767, 19920401
  90. Kinetic studies on androstendione production in ovarian microsomes from immature rats, Biochim. Biophys. Acta, 1125, 335-340, 19920401
  91. Thiobacillus novellus cytochrome c oxidase contains one heme a molecule and one copper atom per catalytic unit, J. Biochem., 111, 46-53, 19920401
  92. Cytochrome P-460 of Nitrosomonas europaea: Further purification and further characterization, J. Biochem., 108, 1016-1021, 19900401
  93. Some properties of Nitrosomonas europaea cytochrome c oxidase (aa3-type) which lacks CuA, J. Biochem., 105, 245-248, 19890401
  94. Catalytic properties of cytochrome c oxidase purified from Nitrosomonas europaea, J. Biochem., 103, 499-503, 19880401
  95. The variety of molecular properties of bacterial cytochromes containing heme a, Ann. New York Acad. Sci., 550, 39-46, 19880401
  96. Purification and some properties of cytochrome b-560 from Nitrosomonas europaea, Plant Cell Physiol., 29, 1077-1079, 19880401
  97. N2O reduction by Azotobacter vinelandii with emphasis on kinetic nitrogen isotope effect, Plant Cell Physiol., 28, 263-271, 19870401
  98. Effects of phospholipid and detergent on bacterial cytochrome c oxidase, Biol. Chem. Hoppe-Seyler, 367, 344, 19860401
  99. Cytochrome a1 of Nitrosomonas europaea resembles aa3-type cytochrome c oxidase in many respects, Biochim. Biophys. Acta, 810, 174-183, 19860401
  100. A comparative survey of sevral bacterial aa3-type cytochrome c oxidase, J. Inorg. Biochem., 23, 273-277, 19850401
  101. Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1866(2), 202102
  102. Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1868(3), 202103
  103. DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(6), 202103

Publications such as books

  1. 2014, Neurosteroids: regional steroidogenesis. In Fifty Years of Cytochrome P450 Research., Springer, 2014
  2. 2010/04, Organophosphates as endocrine disruptors In: T. Satoh, R.C. Gupta (ed.) Anticholinesterase Pesticides, John Wiley & Sons Ltd., 2010, 04, Scholarly Book, Joint work
  3. 2008/03, Delving into the Source of Knowledge (Liberal Arts in the 21st Century) , 2008, 03, Textbook, Compilation, 9784563019044, 260
  4. 1998, Kinetic analysis of successive reactions catalyzed by cytochromes P45017α, lyase and P45011β(共著) , Oxygen Homeostasis and its Dynamics Springer-Verlag, 1998
  5. 1997, P450scc activity in the brain(共著) , Perspectives in Avian Endocrinology Journal of Endocrinology Ltd. = Bristol, 1997
  6. 1995, Neurosteroids in the avian brain , Environmental Impact on Endocrine System in Vertebrates (ed. B. K. Follett= M. M. Aruldhas and S. K. Maitra), 1995, Scholarly Book, Cocompilation, 15
  7. 1993, Cytochrome P-450-linked electeron transport system in monooxygenase , Cytochrome P-450(Kodansha Scientific), 1993, Scholarly Book, Cocompilation, 9
  8. 1992, Control mechanism of P-45011β dependent catalytic activity in bovine adrenal mitochondria , Biotechnological and Ecological Aspects (ed. A.I.Archakov) Taylor and Francis Inc., 1992, Scholarly Book, Cocompilation, 5

Invited Lecture, Oral Presentation, Poster Presentation

  1. Activation of microglia and loss of synapse in the developing hippocampus of mice prenatally treated by valproate, Honda T, Ishihara Y, Ishida A, Yamazaki T, Neuroscience 2017, 2017/11/11, Without Invitation, English, Society for Neuroscience, Washington, DC, USA
  2. A role of microglia in the progression of ischemic brain edema, Tanaka M, Ishihara Y, Itouh K, Ishida, A, Yamazaki T, Neuroscience 2017, 2017/11/11, Without Invitation, English, Society for Neuroscience, Washington DC, USA
  3. Microglial activation and synaptic loss in the hippocampus of mice with prenatal exposure to valproate, Honda T, Yamazaki T, Ishihara Y, Ishida A, The 40th Annual Meeting of the Japan Neuroscience Society, 2017/07/20, Without Invitation, English
  4. A Role of Microglia in the Progression of Ischemic Brain Edema, Tanaka M, Ishihara Y, Itoh K, Ishida A, Yamazaki T, The 40th Annual Meeting of the Japan Neuroscience Society, 2017/07/20, Without Invitation, English
  5. Elongation of seizure latency through dietary supplementation with docosahexaenoic acid, Yamazaki T, Ishihara Y, Tanaka M, Itoh K, Tsuji M, Kawamoto S, Kawato S, Vogel CFA, 2017/12/06, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. 2019
  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2019
  3. 2017, 2019
  4. KAKENHI, 2013, 2015
  5. KAKENHI, 2013, 2015
  6. 2012, 2014
  7. KAKENHI, Protective effect of neurosteroids on developmental brains, 2010, 2012
  8. KAKENHI, Method for Pin-Point Structure Analysis of Proteins by Fluorescence-Detected CD, 2010, 2012
  9. 2009, 2010
  10. KAKENHI, Sensitive assay for disturbance of brain function by environmental pollutants at low concentrations, 2006, 2007
  11. 2002, 2003
  12. KAKENHI, 2002, 2003
  13. KAKENHI, 2001, 2001
  14. KAKENHI, 1999, 1999
  15. KAKENHI, 1998, 1998
  16. KAKENHI, A new reaction scheme of steroidogenic membrane enzymes and its physiological meanings., 1997, 1998
  17. KAKENHI, 1997, 1997
  18. KAKENHI, 1996, 1996
  19. KAKENHI, BIOSYNTHESIS AND ACTION OF NEUROSTEROIDS IN THE BRAIN, 1996, 1997
  20. KAKENHI, 1994, 1994
  21. KAKENHI, 1993, 1993
  22. KAKENHI, Molecular mechanism of aldosterone biosynthesis, 1993, 1994
  23. KAKENHI, A large scale expression of cytochrome P-450XVIIA1 and studeies on the reaction mechanism using membrane reconstituted sysrems., 1993, 1994
  24. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2020, 2022

Social Activities

Organizing Academic Conferences, etc.

  1. 2020/.7

History as Peer Reviews of Academic Papers

  1. 2020, Neuroendcrinology, Editor, 12