YUMIKO SAITO

Last Updated :2021/05/10

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
yumisthiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 1992/04/01, 1997/06/30, Tokyo Metropolitan Institute of Medical Science, ., Researcher
  • 2001/04/01, 2006/09/30, Saitama Medical School, Department of Pharmacology, Lecturer
  • 1987/06/01, 1992/03/31, Tokyo Metropolitan Institute of Gerontology, ., Project Researcher
  • 1997/07/01, 2000/06/30, University of California, Ivine, Associate Specialist
  • 2000/07/01, 2001/03/31, Tokyo Metropolitan Institute of Medical Science, ., Researcher
  • 2006/10/01, 2019/03/31, Hiroshima University, Professor

Educational Backgrounds

  • Ochanomizu University, Graduate School, Division of Natural Science, Japan, 1981/04, 1983/03

Academic Degrees

  • Doctor of Science, The University of Tokyo
  • Master of Science, Ochanomizu University

Research Fields

  • Biological Sciences;Neuroscience;Neurochemistry / Neuropharmacology

Research Keywords

  • feeding
  • RGS protein
  • G protein
  • GPCR-mediated signaling
  • depression and anxiety
  • primary cilia
  • orphan GPCR

Educational Activity

Course in Charge

  1. 2021, Liberal Arts Education Program1, 2Term, Brain and Behavior
  2. 2021, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  3. 2021, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  4. 2021, Undergraduate Education, 1Term, Brain Science
  5. 2021, Undergraduate Education, 2Term, Natural Sciences of Life and Environment
  6. 2021, Undergraduate Education, 2Term, Introduction to Life Sciences
  7. 2021, Undergraduate Education, 1Term, Fundamental Cell Biology
  8. 2021, Undergraduate Education, 2Term, Cell Biology
  9. 2021, Undergraduate Education, 2Term, Laboratory Work in Life Sciences D
  10. 2021, Undergraduate Education, 2Term, Practical Methods in Life Sciences D
  11. 2021, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Life and Environmental Sciences
  12. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Life and Environmental Sciences A
  13. 2021, Graduate Education (Master's Program) , 2Term, Exercises in Life and Environmental Sciences A
  14. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Life and Environmental Sciences B
  15. 2021, Graduate Education (Master's Program) , 4Term, Exercises in Life and Environmental Sciences B
  16. 2021, Graduate Education (Master's Program) , 1Term, Introduction to Integrated Arts and Sciences
  17. 2021, Graduate Education (Master's Program) , 4Term, Advanced Molecular and Cellular Neurobiology
  18. 2021, Graduate Education (Doctoral Program) , 2Term, Seminar in Integrated Arts and Scirnces II
  19. 2021, Graduate Education (Doctoral Program) , 4Term, Exercises in Integrated Life Sciences
  20. 2021, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences

Research Activities

Academic Papers

  1. Required research activities to overcome addiction problems in Japan, Taiwanese J Psychiat, 35, 6-11, 2021, 03, 25
  2. Patterns of cilia gene dysregulations in major psychiatric disorders, Prog Neuropsychopharmacol Biol Psychiatry, 20210125
  3. Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro, Neurochem International, 142, 104902, 202101
  4. Analysis of ciliary status via G-protein-coupled receptors localized on primary cilia, Microscopy, 69(5), 277-285, 20201020
  5. Ciliary cholesterol insufficiency in the peroxisome biogenesis disorder Zellweger syndrome., EMBO J, 39, e103499, 20200505
  6. Dynamic Changes in Ultrastructure of the Primary Cilium in Migrating Neuroblasts in the Postnatal Brain, J Neuroscience, 39, 9967-9988, 20191211
  7. Selective signaling pathways via feeding-related ciliary GPCR, melanin-concentrating hormone receptor 1., Folia Pharmacologica Japonica, 154(4), 179-185, 20191001
  8. Characterization of functional primary cilia in human induced pluripotent stem cell-derived neurons, Neurochemical Research, 44, 1736-1744, 201907
  9. Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT1A receptor via phosphorylation., Biochem Biophys Res Commun, 510, 370-375, 20190312
  10. ★, Depression-resistant phenotype in mice overexpressing regulator of G protein signaling-8 (RGS8), Neuroscience, 383, 160-169, 20180517
  11. Cytoskeleton-related regulation of primary cilia shortening mediated by melanin-concentrating hormone receptor 1, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 253, 44-52, 20170821
  12. Dimerization of melanocortin receptor 1 (MC1R) and MC5R creates a ligand-dependent signal modulation: Potential participation in physiological color change in the flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 230, 103-109, 20160501
  13. ★, Modulation of primary cilia length by melanin-concentrating hormone receptor 1, Cellular Signalling, 28, 572-584, 20160601
  14. Molecular Mechanisms of Melanin-Concentrating Hormone Receptor 1 Internalization, 51(1), 13-16, 20160401
  15. Melanin-concentrating hormone-Current advances, Journal of clinical and experimental medicine, 256(5), 608-6015, 20160130
  16. ★, Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1, Cellular Signalling, 27(4), 818-827, 20150401
  17. Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 212, 114-123, 20150401
  18. Involvement of melanin-concentrating hormone 2 in background color adaptation of barfin flounder Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 214, 140-148, 20150401
  19. Interrelation between melanocyte-stimulating hormone and melanin-concentrating hormone in physiological body color change: Roles emerging from barfin flounder Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 181, 229-234, 20130115
  20. Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 188, 159-165, 20130701
  21. Regulated control of melanin-concentrating hormone receptor 1 through glycosylation and phosphorylation., Frontiers in Endocrinology, 4, e154, 20131001
  22. Mutation of Phe318 within the NPxxY(x)5,6F motif in melanin-concentrating hormone receptor 1 results in an efficient signaling activity., Front. Endocrinology, 20121101
  23. Inhibiting roles of melanin-concentrating hormone for skin pigment dispersion in barfin flounder, Verasper moseri (vol 171, pg 75, 2011), GENERAL AND COMPARATIVE ENDOCRINOLOGY, 179(3), 358-358, 2012
  24. Melanocortin systems on pigment dispersion in fish chromatophores., Frontiers in Experimental Endocrinology, 20120201
  25. Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2, REGULATORY PEPTIDES, 169(1-3), 6-12, 20110808
  26. Signalling pathway of the goldfish melanin-concentrating hormone receptor 1 and 2, Regulatory Peptides, 169, 6-12, 20110601
  27. Melanin: concentrating hormone, 62(1), 37-43, 201101
  28. Identification, Localization, and Function of a Novel Avian Hypothalamic Neuropeptide, 26RFa, and Its Cognate Receptor, G Protein-Coupled Receptor-103, ENDOCRINOLOGY, 151(5), 2255-2264, 201005
  29. Functional interaction of regulator of G-protein-signaling-2 with melanin-concentrating hormone receptor 1, Ann NY Science, 1200, 112-119, 20100401
  30. Identification of amino acid involved in "gain-of-function" conformational dynamics of melanin-concentrating hormone receptor, NEUROSCIENCE RESEARCH, 68, E224-E224, 2010
  31. The anorexic effect of the MCH1 receptor antagonist, TPI1361-17, ENDOCRINE JOURNAL, 57, S435-S435, 2010
  32. Identification, Localization, and Function of a Novel Avian Hypothalamic Neuropeptide, 26RFa, and Its Cognate Receptor, G Protein-Coupled Receptor-103, ENDOCRINOLOGY, 151(5), 2255-2264, 2010
  33. Regulation of somatolactin release from cultured goldfish pituitary cells by PACAP and MCH, JOURNAL OF MOLECULAR NEUROSCIENCE, 42(3), 308-308, 2010
  34. Melanin-concentrating hormone, Japanese journal of clinical medicine, 68(0), 125-128, 201002
  35. Impact of orphan GPCR research: MCH and MCH receptor, 233(9), 687-691, 20100529
  36. The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries, European Journal of Pharmacology, 5, 85-92, 20090101
  37. TH2 cytokines potently induce an orexigenic peptide, melanin-concentrating hormone, in human vascular endothelial cells., Journal of Allergy and Clinical Immunology, 124, 612-614, 20090701
  38. Melanin-concentrating hormone reduces somatolactin release from the cultured goldfish pituitary cells in vitro., Journal of Endocrinology, 203, 389-398, 20091101
  39. Molecular cloning and expression of 2 melanin-concentrating hormone receptors in goldfish., Peptides, 30, 1990-1996, 20090501
  40. Distinct role of the DRY motif in rat melanin-concentrating hormone receptor 1 in signaling control., PEPTIDES, 30, 974, 20090601
  41. MCH receptors/gene structure-in vivo expression., Peptides, 30, 1985-1989, 20090501
  42. The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries, EUROPEAN JOURNAL OF PHARMACOLOGY, 602(2-3), 194-202, 20090114
  43. Distinct roles of the DRY motif in rat melanin-concentrating hormone receptor 1 in signaling control, Peptides, 30(5), 974-981, 200905
  44. Melanin-concentrating hormone reduces somatolactin release from cultured goldfish pituitary cells, JOURNAL OF ENDOCRINOLOGY, 203(3), 389-398, 2009
  45. T(H)2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 124(3), 612-U328, 2009
  46. ★, Regulation of melanin-concentrating hormone receptor 1 signaling by RGS8 with the receptor third intracellular loop. ,, Cellular Signaling, 20, 2084-2094, 20080719
  47. 2S5-4 Regulation of the melanin-concentrating hormone receptor signaling(2S5 Physical studies on the biological functions of G-protein coupled receptors,The 46th Annual Meeting of the Biophysical Society of Japan), Biophysics, 48(1), 20081025
  48. Evolution of the Xenopus piggyBac transposon family TxpB: Domesticated and untamed strategies of transposon subfamilies, MOLECULAR BIOLOGY AND EVOLUTION, 24(12), 2648-2656, 200712
  49. The role of MCH-MCH receptor system in feeding and depression, Folia Pharmacologica Japonica, 130(1), 34-38, 20070701
  50. Lignan compounds and 4,4'-dihydroxybiphenyl protect C2C12 cells against damage from oxidative stress, Biophys Biochem Res Commun, 344, 394-396, 20061001
  51. Kyotorphin has a novel role on rat cardiac muscle, Biophys Biochem Res Commun, 339, 805-809, 20060601
  52. Identification of MCH receptor and its impact on drug discovery, Journal of Experimental Zoology, 305, 761-768, 20061201
  53. Finding a novel target for depression through the orphan receptor strategy, Folia Pharmacologica Japonica, 127(3), 190-195, 20060301
  54. Physiological role of melanin-concentrating hormone and its receptor, Clinical Neuroscience, 24, 968-969, 20060701
  55. The deorphanization of orphan GPCRs., International Review of Neurobiology, 65, 179-209, 2005
  56. Orphan GPCR and their ligands, Pharmacology and Therapeutics, 110, 525-532, 20061001
  57. Salusin beta is a surrogate lignad of the mas-like G-protein-coupled receptor MrgA1, European J Pharmacologu, 145-150, 20060901
  58. Arginine residue 155 in the second intracellular loop plays a critical role in rat melanin-concentrating hormone receptor 1, Endocrinology, 146, 3452-3462, 20050801
  59. ★, The basic residues in the membrane proximal C-terminal tail of the melanin-concentrating hormone receptor 1 is required for receptor function., Endocrinology, 145, 3712-3723, 20040801
  60. Properties of the rat melanin concentrating hormone receptor 1 internalization., Peptides, 25, 1597-1604, 20041101
  61. Role of asparagine-linked oligosaccharides in the function of the melanin-concentrating hormone (MCH) receptor 1., FEBS Letter, 533, 29-34, 20030701
  62. Different structural requirement for melanin-concentrating hormone (MCH) interacting with rat MCHR1 (SLC-1) and mouse B16 cell MCH-R., J. Recept. Signal Transduct., 23, 69-81, 2003
  63. Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain., J. Comp. Neurology, 435, 26, 20011001
  64. Endogenous melanin-concentrating hormone receptor SLC-1 in human melanoma SK-MEL-37 cells, BBRC, 289, 44-50, 20010601
  65. Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors. . 24, 230-237., Trends in Neurosci, 24, 230, 20010801
  66. The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat., Brain Res., 923, 120-127, 2001
  67. Searching for neurotransmitters as cognate ligands of orphan G protein-coupled receptor : Finding receptor for melaninconcentrating hormone, 21(3), 77-82, 20010925
  68. Melanin-concentrating hormone receptor : An orphan receptor fits the key., Trends in Endocrinology and Metabolism, 11, 299, 20001201
  69. Identification of the natural ligand of an orphan G protein-coupled receptor involved in the regulation of vasoconstriction., Nature Cell Biology, 1, 383, 19991101
  70. ★, Molecular characterization of the melanin-concentrating-hormone receptor., Nature, 400, 265, 19990715
  71. Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells., J. Neurosci.Res, 48, 397-406, 1997
  72. ★, Molecular cloning and characterization of a novel form of neuropeptide gene as a developmentally regulated molecule., J. Biol. Chem., 271, 15615, 19961201
  73. Differential Inhibition of Calpain and Proteasone Activities by Peptidyl Aldehydes of Di-Leucine and Tri-Leucine, J Biochem (Tokyo), 119(3), 572-576, 19960301
  74. Expression of dopamine transporter at the tips of growing neurites of PC12h cells., J.Histochem.Cytochem., 44, 989-996, 1996
  75. Identification and characterization of membrane-bound calpains in clathrin-coated vesicles from bovine brain., Eur. J. Biochem., 230, 25-31, 1995
  76. N23K, a gene transiently up-regulated during neural differentiaton, encodes a precursor protein for a new identified neuropeptide nociceptin., Biochem. Biophys. Res. Commun., 217, 539-545, 1995
  77. Expression of a domapine transporter in PC12 cells: an immunohistochemical study with an antipeptide antibody., Acta. Anat. Nipp., 70, 248-251, 1995
  78. The calpain-calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cells., FEBS Lett., 353, 327-331, 1994
  79. Purification and characterization of an endogenous inhibitor specific to the Z-Leu-Leu-Leu-MCA degrading activity in proteasome and its identification as heat-shock protein 90., FEBS lett., 344, 229-233, 1994
  80. The toxic effect of Alzeimer amyloid precursor overexpressed in the neuroblastoma cell line NB-1 on neurite outgrowth., Gerontology, 40, S57-S64, 1994
  81. Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome., Biochem. Biophys. Res. Commun., 196, 1195-1201, 1993
  82. Inhibition of DNA polymerase by tripeptide derivative protease inhibitors., Biochem. Biophys. Res. Commun, 185, 1133-1140, 1992
  83. Possible Involvement of Clathrin in Neuritogenesis Induced by a Protease Inhibitor(Benzyloxycarbonyl-Leu-Leu-Leu-Aldehyde) in PC12 Cells., J Biochem (Tokyo), 112(4), 448-455, 1992
  84. Isolation and characterization of possible target proteins responsible for neurite outgrowth induced by tripeptide aldehyde in PC12 cells., Biochem. Biophys. Res. Commun., 184, 419-426, 1992
  85. Replacement of m-calpain by u-calpain during maturation of megakaryocytes and possible involvement in platelet formation., Thrombos. Res., 66, 757-764, 1992
  86. Calpain activation is essential for membrane fusion of erythrocytes in the presence of calcium., Biochem. Biophys. Res. Commun., 182, 939-946, 1992
  87. The Synthesis and Properties of Tripeptide Aldehydes Having Neurite-Extension Activity, Journal of the Chemical Society of Japan,chemistry and industrial chemistry, 1992(11), 1363-1367, 19921110
  88. Activation of intracellular calcium-activated neutral protease in erythrocytes and its inhibition by exogenously added inhibitors., Biochim. Biophys. Acta., 1094, 256-259, 1991
  89. Possible involvement of a novel protease in neurite outgrowth of PC12 cells, Neurosci. Res., 13, S97-S101, 1990
  90. Binding sites for calcium-activated neutral protease on erythrocyte membrane are not membrane phospholipids., Biochem. Biophys. Res. Commun., 171, 625-632, 1990
  91. The structure-function relationship between peptide aldehyde derivatives on initiation of neurite outgrowth in PC12 cells., Neurosci. Lett., 120, 1-4, 1990
  92. 神経突起伸長におけるプロテアーゼインヒビターの役割, 神経研究の進歩, 34, 632-641, 1990
  93. Properties of membrane binding and autolytic activation of calcium-activated neutral protease., J. Biol. Chem., 264, 18838-18843, 1989
  94. 神経分化におけるプロテアーゼ-プロテアーゼインヒビター系の関与, 11, 625-632, 1989
  95. The neurite-initiating effect of a tripeptide aldehyde protease inhibitor on PC12h cells., J Biochem (Tokyo), 106(6), 1035-1040, 1989
  96. Enhancement of neurite outgrowth in PC12h cells by a protease inhibitor, Neuroscience letters, 89, 102-107, 1988
  97. Tissue distribution of calcium-activated neutral protease in rat., Biochim.Biophys.Acta., 965, 130-135, 1988
  98. Rat atrial natriuretic polypeptide stimulation of adrenal zona glomerulosa cell growth, Biochem. Biophys. Res. Commun, 132(1), 261-263, 19851015

Publications such as books

  1. 2018, Encyclopedia of Signaling Molecules, 2nd Edition, Melanin-concentrating hormone receptor 1, Springer, 2018, Dictionary/Encyclopedia, Joint work, English, Hamamoto A, Kobayashi Y, Saito Y., 3075-3082
  2. 2015/07/16, IUPHAR Database: Melanin-concentrating hormone receptor 1 and 2, 2015/07, 07, Others, Joint work, English, Valérie Audinot, Jean A. Boutin, Bernard Lakaye, Jean-Louis Nahon, Yumito Saito
  3. 2015/10/14, Handbook of Hormones. Comparative Endocrinology for Basic and Clinical Research, Melanin-concentrating hormone (MCH), Elsevier Science & Technology, 2015, 10, Scholarly Book, Joint work, English, Hiroshi Nagasaki, Yumiko Saito, 978-0-12-801028-0, 674
  4. 2015/10/14, Handbook of Hormones. Comparative Endocrinology for Basic and Clinical Research, Cocaine and Amphetamine Regulated Transcript (CART), Elsevier Science & Technology, 2015, 10, Scholarly Book, Joint work, English, Nagasaki H, Kobayashi Y, Saito Y, 978-0-12-801028-0, 674, 4
  5. 2008/01, New frontiers in lifestyle-related diseases , Orphan neuropetides and the regulation of food intake, 2008, 01, Scholarly Book, Cocompilation, 9784431764, 160
  6. 2008/10, Results and Problems in Cell Differentiation-Orphan G protein-coupled receptors and novel neuropeptides, The Melanin-Concentrating Hormone System and Its Physiological Functions, 2008, 10, Scholarly Book, Cocompilation, Nagasaki H, Saito Y, 21
  7. 2008/03, Delving into the Source of Knowledge (Liberal Arts in the 21st Century) , 2008, 03, Textbook, Compilation, 9784563019044, 260
  8. 2005, G-protein Coupled Receptors in Drug Discovery, Orphan G protein-coupled receptors: Promising Targets for Drug Discovery., Taylor & Francis Books, FL, USA., 2005, Scholarly Book, Joint work, 19

Invited Lecture, Oral Presentation, Poster Presentation

  1. Feeding-related GPCR signaling through the neuronal primary cilium, Yumiko Saito, Yuki Kobayashi, The 92th Annual Meeting of Japanese Pharmaceutical Society, 2019/03/14, With Invitation, Japanese, Japanese Pharmacological Society
  2. Neuronal primary cilium as a signaling platform for environmental cue, 2018/09/06, Without Invitation, Japanese
  3. Characterization of primary cilia in human induced pluripotent stem cell-derived cortical neurons, 2018/09/06, Without Invitation, English
  4. Ciliary G-protein-coupled receptor MCHR1 and SSTR3 affects cilia length control via different mechanisms, 2018/09/06, Without Invitation, English
  5. Primary cilia length in energy balance signaling involved in melanin-concentrating hormone receptor, 2018/09/26, Without Invitation, English
  6. Feeding-related neuropeptide receptor MCHR1 localizes to neuronal primary cilia on hippocampal slice culture, Daisuke Miki, Tomoya Okada, Syogo Kobuchi, Yuki Kobayashi, Yumiko Saito, 2018/07/26, Without Invitation, English
  7. Characterization of orexigenic neuropeptide receptor in neuronal primary cilia in vitro and in vitro., Daisuke Miki, Tomoya Okada, Shogo Kobuchi, Yuki Kobayashi and Yumiko Saito, International GPCR symposium, 2018/06/29, Without Invitation, English
  8. Regulator of G protein signaling 8 (RGS8) modulates depression-like behavior via melanin-concentrating hormone receptor 1 activity, Yuki Kobayashi, Tomoya Okada, Risa Takemoto, Shogo Yamato, Michihiko Iijima, Yoshikatsu Uematsu, Shigeyuki Chaki and Yumiko Saito, International GPCR symposium, 2018/06/29, Without Invitation, English
  9. Feeding-related neuropeptide receptor MCHR1 localizes to neuronal primary cilia on hippocampal slice culture, Daisuke Miki Tomoya Okada Yumiko Saito Yuki Kobayashi, Consortium of Biological Sciences 2017, 2017/12, Without Invitation, Japanese
  10. Immunoanalysis of melanin-concentrating hormone receptor 1 located in neuronal primary cilia, Tomoya Okada Shogo Yamato Daisuke Miki Yuki Kobayashi Yumiko Saito, JSN2017, 2017/09/08, Without Invitation, English, Sendai
  11. Two distinct signaling pathways regulate cilia length shortening via ciliary melanin-concentrating hormone receptor 1, Kosuke Imakado Sakura Tomoshige Yuki Kobayashi Yumiko Saito, Consortium of Biological Sciences 2017, 2017/12, Without Invitation, Japanese
  12. Shortening of primary cilia length by melanin-concentrating hormone receptor 1-Gi/o mediated signaling., Yumiko Saito, Akie Hamamoto, Sakura Tomoshige, Shogo Yamato, Kosuke Hosoba, Tatsuo Miyamoto, Yuki Kobayashi, The 28th CDB meeting: Cilia and centrosome, 2016/11/28, Without Invitation, English, Riken, Kobe
  13. What is neuronal cilia ?, Yumiko Saito, 2017/09/10, With Invitation, Japanese
  14. Metabolic GPCR-mediated primary cilia shortening through dynamic cytoskeletal reorganization, Sakura Tomoshige Kousuke Hosoba Akie Hamamoto Shogo Yamato Tatsuo Miyamoto Yuki Kobayashi Yumiko Saito, 2017JSN, 2017/09/08, Without Invitation, English
  15. Melanin-concentrating hormone-mediated signaling induces cilium shortening via Gi/o-dependent Akt phosphorylation., Saito Y, Hamamoto A, Yamoto S, Kobayashi Y., Society for Neuroscience, 2016/11/12, Without Invitation, English
  16. Detection of ciliary GPCR in rodent central nervous system, 2016/05/14, Without Invitation, Japanese
  17. Shortening of primary ciliary length by melanin-concentrating hormone receptor 1., 2016/05/14, Without Invitation, Japanese
  18. Presidential lecture: Searching a novel neurotransmitter/hormone through G-protein coupled receptor Where now and where next ?, Yumiko Saito, 2015/09/13, With Invitation, English, The Japanese Society for Neurochemistry, Omiya
  19. Structure -function insight on the melanin-concentrating hormone receptor 1, Yumiko Saito, 2015/03/23, With Invitation, English
  20. Signaling specificity on the melanin-concentrating hormone receptor 1, Yumiko Saito, 2015/03/20, With Invitation, English
  21. Regulation of cilium length via melanin-concentrating hormone receptor 1, 2015/12/03, Without Invitation, English
  22. The intracellular residues which are important for the selective activation of Gi/o proteins in rat melanin-concentrating hormone receptor 1, Hamamoto A, Kobayashi Y, Saito Y., 6th Special Conference of International Society for Neurochemistry, 2014/09/21, Without Invitation, English
  23. A screening of new agonist for BRS-3 from a marine metagenome library, 2014/09, Without Invitation, English
  24. Regulaton of depression-related receptor signaling by Regulator of G protein signaling-8(RGS8), 2014/09, Without Invitation, English
  25. The intracellular residues which are important for the selective activation of Gi/o proteins in rat melanin-concentrating hormone, 2014/09, Without Invitation, English
  26. Identification of discrete amino acids that responsible for Gi/o selectivity by melanin-concentrating hormone receptor 1.Society for Neuroscience, A. Hamamoto、Y. Kobayashi、M. Horikawa、Y. Saito, Society for Neurosciecne, 2013/11, Without Invitation, English
  27. A. Hamamoto、Y. Kobayashi、Y. Saito.The structure-activity relationship in rat melanin-concentrating hormone receptor 1 -Structural determinants for G-protein selectivity., A. Hamamoto、Y. Kobayashi、Y. Saito., Neuro2013, 2013/06, Without Invitation, English
  28. The “gain-of-function” phenotype of rat melanin-concentrating hormone receptor., A. Hamamoto、M. Horikawa、Y. Saito., Congress Secretariat for The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry The 55th Annual Meeting of the Japanese Society for Neurochemistry, 2012/09/30, Without Invitation, English
  29. Identification of the determinant sites of Gi/o coupling by rat melanin-concentrating hormone receptor 1., 2011/09/27, Without Invitation, English
  30. Identification of ciliary targeting sequence of MCHR1 to primary cilia, 2011/09/26, Without Invitation, English
  31. Regulation of tachykinin receptor 1 signaling by regulator of G protein signaling-8 (RSG8), 2011/09/26, Without Invitation, English
  32. Identification of MCH receptor and its impact on drug discovery, Yumiko Saito, The 15th International coference of comparative endocrinology, 2005/05/25, With Invitation, English, Boston, USA
  33. The structure-function relationship of rat MCH receptor 1, Yumiko Saito, 2003/03, With Invitation, English, National Institute of Genetics
  34. MCH is the cognate ligand for the orphan GPCR: Feeding hormone finds its partner., Yumiko Saito, 2000/04/06, With Invitation, English, Dept. Medicine, Southern Illinois University
  35. Melanin-concentrating hormone is a cognate ligand for the orphan GPCR, Yumiko Saito, Riken, Wako, 2000/07, With Invitation, English
  36. Identification of MCH receptor, Yumiko Saito, UCI Neuroscience meeting, 1999/10/14, With Invitation, English, University of California, Irvine, Irvine, USA
  37. The growth promoting effect of orphaninFQ/nociceptin gene, Yumiko Saito, Seiichi Kawashima, The 28th International Narcotic Meeting, 1997/08/03, With Invitation, English, International Narcotic Society, Hong Kong
  38. Initiation of neurite outgrowth by tripeptide aldehyde derivatives., Seiichi Kawashima, Yumiko Saito, 1990/01, With Invitation, English

Awards

  1. 2011/09/30, special commendation award for grants in aid for scientific research in 2011, 独立行政法人日本学術振興会理事長 小野 元之

Social Activities

History as Committee Members

  1. Science Council of Japan, 2017/10, 2023/09, Science Council of Japan
  2. local organizing committee, 2014/09, 6th Special Conference of International Society for Neurochemistry