Ichiro Takahashi

Last Updated :2025/03/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
E-mail
snatumhiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor
  • 2002/04/01, 2019/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Professor
  • 1996/06/01, 2002/03/31, Osaka University Research Inst. Microbial Diseases, Assistant Professor

Educational Backgrounds

  • Osaka University, Japan, 1984/04, 1988/03
  • Kagoshima University, Japan, 1978/04, 1984/03

Academic Degrees

  • Doctor of Philosophy in Dental Science, Osaka University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

In Charge of Primary Major Programs

  • Dentistry

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Immunology

Research Keywords

  • Mucosal Immunity
  • Innate inflammation in the intestinal mucosa
  • Persistent symbiotic colonization of tissue resident macrophages with commensal bacteria
  • tissue resident macrophage
  • immunometabolism
  • Iron metabolism

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 4Term, Immunology
  2. 2024, Undergraduate Education, First Semester, Basic Technique for Microbiology and Immunology
  3. 2024, Undergraduate Education, 2Term, Basic and clinical integrated theory
  4. 2024, Undergraduate Education, First Semester, Dental Research Practices III
  5. 2024, Graduate Education (Master's Program) , First Semester, Seminar
  6. 2024, Graduate Education (Master's Program) , Second Semester, Seminar
  7. 2024, Graduate Education (Master's Program) , First Semester, Research
  8. 2024, Graduate Education (Master's Program) , Second Semester, Research
  9. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  10. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  11. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  12. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  13. 2024, Graduate Education (Master's Program) , 3Term, Seminar on Host Defense
  14. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Mucosal Immunology
  15. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Mucosal Immunology
  16. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Mucosal Immunology
  17. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Mucosal Immunology

Research Activities

Academic Papers

  1. New horizon of mucosal immunity and vaccines., New horizon of mucosal immunity and vaccines., 21(3), 2009
  2. ★, Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia, INTERNATIONAL IMMUNOLOGY, 32(2), 133-141, 2020
    Link to Paper Search Results by DOI
  3. Analysis of hypoxia-associated dendritic cells in colitic mice and effects of probiotics on IL-10 production in inflammatory dendritic-cells under hypoxia., Beneficial Microbes, 10(7), 801-810, 2019
  4. Mucosal regulatory cells in the gastrointestinal tract and periodontium, Periodontology2000, 54, 247-256, 2010
  5. ★, New horizon of mucosal immunity and vaccines, CURRENT OPINION IN IMMUNOLOGY, 21(3), 352-358, 2009
    Link to Paper Search Results by DOI
  6. ★, Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine, IMMUNOLOGICAL REVIEWS, 215, 136-153, 2007
    Link to Paper Search Results by DOI
  7. ★, Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells, Gastroenterology, 128, 922-934, 2005
  8. Clonal expansion of double-positive IELs by MICA expressed in mouse small intestinal epithelium., Journal of Immunology, 171, 4131-4139, 2003
  9. Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: Preferential localization of claudin-4 at the apex of the dome region, LABORATORY INVESTIGATION, 83(7), 1045-1053, 200307
    Link to Paper Search Results by DOI
  10. ★, Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice., Gastroenterology, 122, 1829-1841, 2002
  11. Sendai virus fusion protein-mediates simultaneous induction of MHC class I/II-dependent mucosal and systemic immune responses via the nasopharyngeal-associated lymphoreticular tissue immune system., Journal of Immunology, 167, 1406-1412, 2001
  12. Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice., Journal of Experimental Medicine, 190, 607-615, 1999
  13. ★, CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha chain-deficient mice., Gastroenterology, 112, 1876-1886, 1997
  14. Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile toxin., Journal of Infectious Diseases, 173, 627-635, 1996
  15. Oral immunization with B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyerﾕs patches., Journal of Infectious Diseases, 173, 1428-1436, 1996
  16. ★, Requirement of a properly acylated beta(1-6)-D-glucosamine disaccharide bisphosphate structure for efficient manifestation of full endotoxic and associated bioactivities of lipid A., Infection and Immunity, 55, 57-68, 1987

Invited Lecture, Oral Presentation, Poster Presentation

  1. Molecular basis for symbiotic cohabitation of rhizosphere-derived Stenotrophomonas maltophilia in colon resident macrophages, Ichiro Takahashi, Daiki Yamamoto, Yuria Asao, Ayumi Hashimoto, Yosuke Kurashima, Jun Kunisawa, Shintaro Sato, and Hiroshi Kiyono, Hiroko Tsutsui, Mosche Arditi, 17th International Congress of Mucosal Immunology, 2015/07/16, Without Invitation, English, Society for Mucosal Immunology, Berlin, Germany