Last Updated :2023/02/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Contributing Professor
My specialty is Diabetology.

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Metabolomics

Research Keywords

  • Diabetology

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2022, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2022, Undergraduate Education, Intensive, Practice of Medicine II
  4. 2022, Graduate Education (Master's Program) , 1Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance A

Research Activities

Academic Papers

  1. Significantly high level of late-night free cortisol to creatinine ratio in urine specimen in patients with subclinical Cushing's syndrome, CLINICAL ENDOCRINOLOGY, 79(5), 617-622, 201311
  2. ★, Prevalence of metabolic syndrome compared betwee native Japanese and Japanese-Americans, DIABETES RESEARCH AND CLINICAL PRACTICE, 79(3), 518-522, 2007
  3. Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase, OBESITY RESEARCH & CLINICAL PRACTICE, 4(3), E201-E207, 2010
  4. Associations between Small Dense LDL, HDL Subfractions (HDL2, HDL3) and Risk of Atherosclerosis in Japanese-Americans, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 19(5), 444-452, 2012
  5. Low high-density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes: Data from the Hawaii-Los Angeles-Hiroshima study, JOURNAL OF DIABETES INVESTIGATION, 5(5), 501-506, 201409
  6. Relationship between Serum Cholesterol Efflux Capacity and Glucose Intolerance in Japanese-Americans, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 21(10), 1087-1097, 2014
  7. Japanese Lifestyle during Childhood Prevents the Future Development of Obesity among Japanese-Americans, PLOS ONE, 10(3), 20150325
  8. Activation of Classical Brown Adipocytes in the Adult Human Perirenal Depot Is Highly Correlated with PRDM16-EHMT1 Complex Expression, PLOS ONE, 10(3), 20150326
  9. Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet, PLOS ONE, 10(8), 20150812
  10. Regardless of central obesity, metabolic syndrome is a significant predictor of type2 diabetes in Japanese Americans, JOURNAL OF DIABETES INVESTIGATION, 6(5), 527-532, 201509
  11. Efficacy and safety of insulin degludec in Japanese patients with type 1 and type 2 diabetes: 24-week results from the observational study in routine clinical practice, JOURNAL OF DIABETES INVESTIGATION, 7(1), 94-99, 201601
  12. Hypothalamic-pituitary-adrenal axis activity is associated with the prevalence of chronic kidney disease in diabetic patients, ENDOCRINE JOURNAL, 63(2), 119-126, 2016
  13. Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma, MEDICINE, 95(20), 201605
  14. Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma, HYPERTENSION, 68(6), 1432-1437, 201612
  15. Westernization of lifestyle affects quantitative and qualitative changes in adiponectin, CARDIOVASCULAR DIABETOLOGY, 16, 20170706
  16. Association between aerobic capacity and the improvement in glycemic control after the exercise training in type 2 diabetes, DIABETOLOGY & METABOLIC SYNDROME, 9, 20170818
  17. Association of type 2 diabetes and an inflammatory marker with incident bone fracture among a Japanese cohort, JOURNAL OF DIABETES INVESTIGATION, 8(5), 709-715, 201709
  18. Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model, JOURNAL OF GASTROENTEROLOGY, 52(11), 1180-1191, 201711
  19. Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma, HYPERTENSION, 71(1), 125-133, 201801
  20. Progression of Carotid Atherosclerosis in Two Japanese Populations with Different Lifestyles, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 24(10), 1069-1074, 2017
  21. Association between Serum Elaidic Acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 24(12), 1206-1214, 2017
  22. Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 461(C), 100-104, 20180205
  23. Body composition and development of diabetes: a 15-year follow-up study in a Japanese population, EUROPEAN JOURNAL OF CLINICAL NUTRITION, 72(3), 374-380, 201803
  24. Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 103(3), 965-971, 201803
  25. Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels, STEROIDS, 140, 179-184, 201812
  26. Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 185, 137-141, 201901
  27. Comparison of insulin glargine 300 U/mL and insulin degludec using flash glucose monitoring: A randomized cross-over study, JOURNAL OF DIABETES INVESTIGATION, 10(2), 352-357, 201903
  28. Associations of nutrient intakes with obesity and diabetes mellitus in the longitudinal medical surveys of Japanese Americans, JOURNAL OF DIABETES INVESTIGATION, 10(5), 1229-1236, 201909
  29. Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men, JOURNAL OF DIABETES INVESTIGATION, 10(6), 1463-1470, 201911
  30. Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75(2), 492-499, 202002
  31. Associations of nutrient intakes with glaucoma among Japanese Americans, MEDICINE, 98(49), 201912
  32. Effect of the use of passive body trunk exercise equipment on oxygen consumption and self-efficacy for carrying out exercise in patients with type 2 diabetes, JOURNAL OF DIABETES INVESTIGATION, 11(5), 1265-1271, 202009
  33. A 50-year history of the health impacts of Westernization on the lifestyle of Japanese Americans: A focus on the Hawaii-Los Angeles-Hiroshima Study, JOURNAL OF DIABETES INVESTIGATION, 11(6), 1382-1387, 202011
  34. Variation in plasma glucagon levels according to obesity status in Japanese Americans with normal glucose tolerance, ENDOCRINE JOURNAL, 68(1), 95-102, 2021
  35. Westernization of Lifestyle and Atherosclerosis in the Japanese: Lessons from the Hawaii - Los Angeles - Hiroshima Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 28(3), 214-222, 202103
  36. Update on Genetics of Primary Aldosteronism, BIOMEDICINES, 9(4), 202104