Shigeto Yamawaki

Last Updated :2023/02/02

Affiliations, Positions
Brain, Mind and KANSEI Sciences Reserch Center, Professor (Special Appointment)
Web Site
Other Contact Details
1-2-3,Kasumi,Minami-ku,Hiroshima, Japan
TEL : (+81)82-257-1724 FAX : (+81)
Graduated from School of Medicine, Hiroshima University, Japan in 1979. Professor and Chairman of the department of Psychiatry and Neurosciences, Hiroshima University(1990-2017) and now Special-appointed Professor and Professor Emeritus(2017-). President of the International College of Geriatric Psychoneuropharmacology (ICGP) (2006-2008), a founding President of the Asian College of Neuropsychopharmacology (AsCNP) (2008-2010), President of the International College of Neuropsychopharmacology (CINP) (2014-2016) and a chief of the Brain and Mind Science Committee of the Japan Science Council (2014-). His majors are clinical psychiatry, neurobiology and neuroimaging of depressive disorder. His recent interests are focused on the neuroimaging study on affection and KANSEI using functional MRI (fMRI) and artificial intelligence (AI) technology. He has served as a team leader of AMED Depression Brain Science Research Project and a research leader of Center of Innovation (COI), KANSEI Research Project(2013-2020).

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Psychiatric science

Research Keywords

  • Psychoimmunology
  • Treatment
  • Psychooncology
  • Psychiatric Approach
  • Pathophysiology
  • Neuroscience
  • Cancer Patients
  • Neuroleptic Malignant Syndrome
  • Depression

Research Activities

Academic Papers

  1. Interoceptive accuracy is related to the psychological mechanisms of the burning mouth syndrome: a cross-sectional study, BMC ORAL HEALTH, 22(1), 20220719
  2. Spike firing attenuation of serotonin neurons in learned helplessness rats is reversed by ketamine, BRAIN COMMUNICATIONS, 3(4), 20211001
  3. An insula hierarchical network architecture for active interoceptive inference, ROYAL SOCIETY OPEN SCIENCE, 9(6), 20220629
  4. Increased cerebrovascular reactivity in selected brain regions after extracranial-intracranial bypass improves the speed and accuracy of visual cancellation in patients with severe steno-occlusive disease: a preliminary study, NEUROSURGICAL REVIEW, 45(3), 2257-2268, 202206
  5. Does low self-esteem enhance social pain? The relationship between trait self-esteem and anterior cingulate cortex activation induced by ostracism, SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 5(4), 385-391, 201012
  6. Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: A preliminary resting-state fMRI study, PSYCHIATRY RESEARCH-NEUROIMAGING, 221(3), 246-248, 20140330
  7. Effects of dopaminergic and serotonergic drugs on ethanol-induced hypothermia, Life Sciences, 467-474, 19840401
  8. Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynaptses in rat brain, Neuropsychobiology, 19-26, 19860401
  9. Profiles of clinical efficacy and pharmacological action of zotepine, Pharmacopsychiatry, 4-7, 19870401
  11. Serotonin Affects Association of Aversive Outcomes to Past Actions, JOURNAL OF NEUROSCIENCE, 29(50), 15669-15674, 20091216
  12. Higher incidence of hysterectomy and oophorectomy in women suffering from clinical depression: Retrospective chart review, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 64(1), 95-98, 2010
  13. Sadness enhances the experience of pain via neural activation in the anterior cingulate cortex and amygdala: An fMRI study, NEUROIMAGE, 50(3), 1194-1201, 20100415
  14. Neural processing of negative word stimuli concerning body image in patients with eating disorders: An fMRI study, NEUROIMAGE, 50(3), 1333-1339, 20100415
  15. Brain activation during the perception of distorted body images in eating disorders, PSYCHIATRY RESEARCH-NEUROIMAGING, 181(3), 183-192, 20100330
  16. Psychosocial functioning in patients with treatment-resistant depression after group cognitive behavioral therapy, BMC PSYCHIATRY, 10, 20100316
  17. Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity, JOURNAL OF AFFECTIVE DISORDERS, 122(1-2), 76-85, 201004
  18. Psychological distress related to patterns of family functioning among Japanese childhood cancer survivors and their parents, PSYCHO-ONCOLOGY, 19(5), 545-552, 201005
  19. Long-Term Prognosis of Patients with Major Depression and Silent Cerebral Infarction, NEUROPSYCHOBIOLOGY, 62(3), 177-181, 2010
  20. DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression, PLOS ONE, 6(8), 20110830
  21. Alterations in the hippocampal glycinergic system in an animal model of posttraumatic stress disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 44(15), 1069-1074, 201011
  22. Epigenetic Regulation of BDNF Gene in Response to Stress, PSYCHIATRY INVESTIGATION, 7(4), 251-256, 201012
  23. Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change: A resting state functional magnetic resonance imaging study, NEUROSCIENCE RESEARCH, 69(2), 129-134, 201102
  24. Post-stroke depression and apathy: Interactions between functional recovery, lesion location, and emotional response, PSYCHOGERIATRICS, 11(1), 68-76, 201103
  25. Personality traits and the amplitude of spontaneous low-frequency oscillations during resting state, NEUROSCIENCE LETTERS, 492(2), 109-113, 20110401
  26. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 45(4), 460-468, 201104
  27. Inter-individual discount factor differences in reward prediction are topographically associated with caudate activation, EXPERIMENTAL BRAIN RESEARCH, 212(4), 593-601, 201108
  28. The Effect of Negative and Positive Emotionality on Associative Memory: An fMRI Study, PLOS ONE, 6(9), 20110914
  29. Asymmetric alternation of the hemodynamic response at the prefrontal cortex in patients with schizophrenia during electroconvulsive therapy: A near-infrared spectroscopy study, BRAIN RESEARCH, 1410, 132-140, 20110902
  30. Serum Brain-derived Neurotrophic Factor and Antidepressant-naive Major Depression After Lung Cancer Diagnosis, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 41(10), 1233-1237, 201110
  31. Neural and Personality Correlates of Individual Differences Related to the Effects of Acute Tryptophan Depletion on Future Reward Evaluation, NEUROPSYCHOBIOLOGY, 65(2), 55-64, 2012
  32. Effects of depression on reward-based decision making and variability of action in probabilistic learning, JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY, 43(4), 1088-1094, 201212
  33. Brain activation during the perception of stressful word stimuli concerning interpersonal relationships in anorexia nervosa patients with high degrees of alexithymia in an fMRI paradigm, PSYCHIATRY RESEARCH-NEUROIMAGING, 201(2), 113-119, 20120228
  34. Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene, JOURNAL OF PSYCHIATRIC RESEARCH, 46(5), 635-643, 201205
  35. Mood dysregulation and stabilization: perspectives from emotional cognitive neuroscience, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 15(5), 681-694, 201206
  36. Sadness Enhances the Experience of Pain and Affects Pain-Evoked Cortical Activities: An MEG Study, JOURNAL OF PAIN, 13(7), 628-635, 201207
  38. Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus, WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 13(6), 458-467, 201209
  39. Depressive symptoms and apathy are associated with psychomotor slowness and frontal activation, EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 262(6), 493-499, 201209
  40. Predictors of quality of life in inpatients with schizophrenia, PSYCHIATRY RESEARCH, 197(3), 199-205, 20120530
  41. Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16(2), 339-350, 201303
  42. Negative Correlation between Affective Symptoms and Prefrontal Activation during a Verbal Fluency Task: A Near-Infrared Spectroscopy Study, NEUROPSYCHOBIOLOGY, 67(2), 103-110, 2013
  43. The degree of early life stress predicts decreased medial prefrontal activations and the shift from internally to externally guided decision making: an exploratory NIRS study during resting state and self-oriented task, FRONTIERS IN HUMAN NEUROSCIENCE, 7, 20130703
  44. Vorinostat ameliorates impaired fear extinction possibly via the hippocampal NMDA-CaMKII pathway in an animal model of posttraumatic stress disorder, PSYCHOPHARMACOLOGY, 229(1), 51-62, 201309
  45. Automatic and Intentional Brain Responses during Evaluation of Face Approachability: Correlations with Trait Anxiety, NEUROPSYCHOBIOLOGY, 68(3), 156-167, 2013
  46. Yokukansan Treatment of Chronic Renal Failure Patients Receiving Hemodialysis, with Behavioral and Psychological Symptoms of Dementia: An Open-Label Study, AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 21(11), 1082-1085, 201311
  47. Cognitive behavioral therapy for depression changes medial prefrontal and ventral anterior cingulate cortex activity associated with self-referential processing, SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 9(4), 487-493, 201404
  48. Neuroanatomic pathway associated with attentional deficits after stroke, BRAIN RESEARCH, 1544, 25-32, 20140128
  49. Psychosocial functioning is correlated with activation in the anterior cingulate cortex and left lateral prefrontal cortex during a verbal fluency task in euthymic bipolar disorder: A preliminary fMRI study, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 68(3), 188-196, 201403
  50. Visual imagery while reading concrete and abstract Japanese kanji words: An fMRI study, NEUROSCIENCE RESEARCH, 79, 61-66, 201402
  51. The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression, JOURNAL OF PSYCHIATRIC RESEARCH, 53, 47-53, 201406
  52. A proposal for an updated neuropsychopharmacological nomenclature, EUROPEAN NEUROPSYCHOPHARMACOLOGY, 24(7), 1005-1014, 201407
  53. Neural Basis of Anticipatory Anxiety Reappraisals, PLOS ONE, 9(7), 20140721
  54. Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study, JOURNAL OF AFFECTIVE DISORDERS, 168, 229-235, 20141015
  55. Behavioral characteristics of subthreshold depression, JOURNAL OF AFFECTIVE DISORDERS, 168, 472-475, 20141015
  56. The dorsolateral prefrontal network is involved in pain perception in knee osteoarthritis patients, NEUROSCIENCE LETTERS, 581, 109-114, 20141003
  57. Hippocampal activation during associative encoding of word pairs and its relation to symptomatic improvement in depression: A functional and volumetric MRI study, JOURNAL OF AFFECTIVE DISORDERS, 152, 462-467, 201401
  58. Factors associated with the risk of relapse in schizophrenic patients after a response to electroconvulsive therapy: a retrospective study, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 11, 67-73, 2015
  59. Toward Probabilistic Diagnosis and Understanding of Depression Based on Functional MRI Data Analysis with Logistic Group LASSO, PLOS ONE, 10(5), e0123524, 20150501
  60. fMRI Study of Social Anxiety during Social Ostracism with and without Emotional Support, PLOS ONE, 10(5), e0127426, 20150522
  61. BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(23), E3067-E3074, 20150609
  62. The potential use of histone deacetylase inhibitors in the treatment of depression, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 64, 320-324, 20160104
  63. Do Individuals with Alcohol Dependence Show Higher Unfairness Sensitivity? The Relationship Between Impulsivity and Unfairness Sensitivity in Alcohol-Dependent Adults, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 39(10), 2016-2021, 201510
  64. Direct and indirect influences of childhood abuse on depression symptoms in patients with major depressive disorder, BMC PSYCHIATRY, 15, 20151014
  65. Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task, JOURNAL OF AFFECTIVE DISORDERS, 189, 254-262, 20160101
  66. Effectiveness of group cognitive behavioral therapy for somatoform pain disorder patients in Japan: A preliminary non-case-control study, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 69(12), 763-772, 201512
  67. A review of the current nomenclature for psychotropic agents and an introduction to the Neuroscience-based Nomenclature, EUROPEAN NEUROPSYCHOPHARMACOLOGY, 25(12), 2318-2325, 201512
  68. Changes in the regional cerebral blood flow detected by arterial spin labeling after 6-week escitalopram treatment for major depressive disorder, JOURNAL OF AFFECTIVE DISORDERS, 194, 135-143, 201604
  69. Association of thalamic hyperactivity with treatment-resistant depression and poor response in early treatment for major depression: a resting-state fMRI study using fractional amplitude of low-frequency fluctuations, TRANSLATIONAL PSYCHIATRY, 6, e754, 20160308
  70. Mechanisms of behavioral activation for late adolescents: Positive reinforcement mediate the relationship between activation and depressive symptoms from pre-treatment to post-treatment, JOURNAL OF AFFECTIVE DISORDERS, 204, 70-73, 20161101
  71. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia. Part 3: Update 2015 Management of special circumstances: Depression, Suicidality, substance use disorders and pregnancy and lactation., Journal The World Journal of Biological Psychiatry, 16(3), 142-170, 2015
  72. Altered Serum Levels of Matrix Metalloproteinase-2,-9 in Response to Electroconvulsive Therapy for Mood Disorders, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19(9), 201609
  73. Behavioral activation for late adolescents with subthreshold depression: a randomized controlled trial, EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 25(11), 1171-1182, 201611
  74. Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 13, 25-33, 2017
  75. Factors associated with relapse after a response to electroconvulsive therapy in unipolar versus bipolar depression, JOURNAL OF AFFECTIVE DISORDERS, 208, 113-119, 20170115
  76. Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices, JOURNAL OF AFFECTIVE DISORDERS, 208, 610-614, 20170115
  77. Increased amygdala reactivity following early life stress: a potential resilience enhancer role, BMC PSYCHIATRY, 17, 20170118
  78. Effects of behavioural activation on the neural basis of other perspective self-referential processing in subthreshold depression: a functional magnetic resonance imaging study, PSYCHOLOGICAL MEDICINE, 47(5), 877-888, 201704
  79. Disrupted Brain Activation and Deactivation Pattern during Semantic Verbal Fluency Task in Patients with Major Depression, NEUROPSYCHOBIOLOGY, 74(2), 69-77, 2016
  80. Subjectivity of the Anomalous Sense of Self Is Represented in Gray Matter Volume in the Brain, FRONTIERS IN HUMAN NEUROSCIENCE, 11, 20170509
  81. Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 20(4), 20170401
  82. Neuroanatomic pathways associated with monoaminergic dysregulation after stroke, INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 32(6), 633-642, 201706
  83. Regional brain functions in the resting state indicative of potential differences between depression and chronic pain, SCIENTIFIC REPORTS, 7, 20170607
  84. The neural correlates of the metacognitive function of other perspective: a multiple regression analysis study, NEUROREPORT, 28(11), 671-676, 20170802
  85. Prediction of clinical depression scores and detection of changes in whole-brain using resting-state functional MRI data with partial least squares regression, PLOS ONE, 12(7), 20170712
  86. Patients with major depressive disorder exhibit reduced reward size coding in the striatum, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 79, 317-323, 20171003
  87. Multiple co-clustering based on nonparametric mixture models with heterogeneous marginal distributions, PLOS ONE, 12(10), 20171019
  88. BDNF as a possible modulator of EEG oscillatory response at the parietal cortex during visuo-tactile integration processes using a rubber hand, NEUROSCIENCE RESEARCH, 124, 16-24, 201711
  89. Functional alterations of Postcentral gyrus Modulated by angry Facial expressions during intraoral Tactile stimuli in Patients with Burning Mouth syndrome: a Functional Magnetic resonance imaging study, FRONTIERS IN PSYCHIATRY, 8, 20171106
  90. Effects of behavioral activation on default mode network connectivity in subthreshold depression: A preliminary resting-state fMRI study, JOURNAL OF AFFECTIVE DISORDERS, 227, 156-163, 201802
  91. Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice, BRAIN RESEARCH, 1680, 13-38, 20180201
  92. Quantitative Evaluation of Pain during Electrocutaneous Stimulation using a Log-Linearized Peripheral Arterial Viscoelastic Model, SCIENTIFIC REPORTS, 8, 3091, 20180215
  93. Changes in resting-state brain networks after cognitive-behavioral therapy for chronic pain, PSYCHOLOGICAL MEDICINE, 48(7), 1148-1156, 201805
  94. Predictors of negative symptoms in the chronic phase of schizophrenia: A cross-sectional study, PSYCHIATRY RESEARCH, 262, 600-608, 201804
  95. Initial severity of major depression and efficacy of new generation antidepressants: individual participant data meta-analysis, ACTA PSYCHIATRICA SCANDINAVICA, 137(6), 450-458, 201806
  96. Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates, MOLECULAR PSYCHIATRY, 23(6), 1432-1445, 201806
  97. Affective auditory stimulus database: An expanded version of the International Affective Digitized Sounds (IADS-E), BEHAVIOR RESEARCH METHODS, 50(4), 1415-1429, 201808
  98. Effects of behavioural activation on the neural circuit related to intrinsic motivation, BJPSYCH OPEN, 4(5), 317-323, 201809
  99. Effects of behavioral activation program without psychotropic medication treatment for depression in late adolescence: case report, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 14, 2159-2164, 2018
  100. Enduring effects of a 5-week behavioral activation program for subthreshold depression among late adolescents: an exploratory randomized controlled trial, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 14, 2633-2641, 2018
  101. Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder, FRONTIERS IN PSYCHIATRY, 9, 691, 20181212
  102. Distinctive Neuroanatomical Substrates for Depression in Bipolar Disorder versus Major Depressive Disorder, CEREBRAL CORTEX, 29(1), 202-214, 201901
  103. Exploratory analyses of effect modifiers in the antidepressant treatment of major depression: Individual-participant data meta-analysis of 2803 participants in seven placebo-controlled randomized trials, JOURNAL OF AFFECTIVE DISORDERS, 250, 419-424, 20190501
  104. Development of fMRI-Compatible Steering Reaction Force Generation Unit, IEEE-ASME TRANSACTIONS ON MECHATRONICS, 24(2), 549-560, 201904
  105. Identification of depression subtypes and relevant brain regions using a data-driven approach, SCIENTIFIC REPORTS, 8, 14082, 20180920
  106. Reduced Serum and Cerebrospinal Fluid Levels of Autotaxin in Major Depressive Disorder, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 22(4), 261-269, 201904
  107. Development and validation of a prediction model for the probability of responding to placebo in antidepressant trials: a pooled analysis of individual patient data, EVIDENCE-BASED MENTAL HEALTH, 22(1), 10-16, 201902
  108. Towards objective olfactory evaluation based on peripheral arterial stiffness and heart rate variability indices., Conf Proc IEEE Eng Med Biol Soc., 2018, 5618-5623, 2018
  109. Predicting Ventral Striatal Activation During Reward Anticipation From Functional Connectivity at Rest, FRONTIERS IN HUMAN NEUROSCIENCE, 13, 289, 20190827
  110. Alcohol Use Disorders Identification Test-consumption Predicts the Risk of Excessive Alcohol Consumption After Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 51(6), 1934-1938, 2019
  111. Role of coping with negative emotions in cognitive behavioral therapy for persistent somatoform pain disorder: Is it more important than pain catastrophizing?, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 73(9), 560-565, 201909
  112. Controlled emotional tactile stimulation during functional magnetic resonance imaging and electroencephalography, JOURNAL OF NEUROSCIENCE METHODS, 327, 108393, 20191101
  113. Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice, NEUROCHEMISTRY INTERNATIONAL, 131, 104563, 201912
  114. Reliability and validity of the Children's Depression Inventory-Japanese version, PEDIATRICS INTERNATIONAL, 61(11), 1159-1167, 201911
  115. Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress, NEUROPHARMACOLOGY, 162, 107835, 20200101
  116. The Shape of Water Stream Induces Differences in P300 and Alpha Oscillation, FRONTIERS IN HUMAN NEUROSCIENCE, 13, 460, 20200120
  117. Predicting antidepressant response through early improvement of individual symptoms of depression incorporating baseline characteristics of patients: An individual patient data meta-analysis, JOURNAL OF PSYCHIATRIC RESEARCH, 125, 85-90, 202006
  118. Importance of the Habenula for Avoidance Learning Including Contextual Cues in the Human Brain: A Preliminary fMRI Study, FRONTIERS IN HUMAN NEUROSCIENCE, 14, 20200512
  119. Antidepressive effect of left dorsolateral prefrontal cortex neurofeedback in patients with major depressive disorder: A preliminary report, JOURNAL OF AFFECTIVE DISORDERS, 271, 224-227, 20200615
  120. The Shape of a Vehicle Windshield Affects Reaction Time and Brain Activity During a Target Detection Task, FRONTIERS IN HUMAN NEUROSCIENCE, 14, 183, 20200526
  121. Enhancing Multi-Center Generalization of Machine Learning-Based Depression Diagnosis From Resting-State fMRI, FRONTIERS IN PSYCHIATRY, 11, 400, 20200528
  122. Quantification of anticipation of excitement with a three-axial model of emotion with EEG, JOURNAL OF NEURAL ENGINEERING, 17(3), 036011, 20200601
  123. Neuroimaging studies about the relationship between negative emotions and pain, PAIN RESEARCH, 35(1), 17-23, 2020
  124. Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants, SCIENTIFIC REPORTS, 10(1), 3542, 20200226
  125. Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis, SCIENTIFIC REPORTS, 10(1), 16822, 20201008
  126. Lesions in the right Rolandic operculum are associated with self-rating affective and apathetic depressive symptoms for post-stroke patients, SCIENTIFIC REPORTS, 10(1), 20264, 20201120
  127. Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix, NEUROPSYCHOPHARMACOLOGY, 46(2), 442-454, 202101
  128. Relationships between motor and cognitive functions and subsequent post-stroke mood disorders revealed by machine learning analysis, SCIENTIFIC REPORTS, 10(1), 19571, 20201111
  129. Is Human Brain Activity During Driving Operations Modulated by the Viscoelastic Characteristics of a Steering Wheel?: An fMRI Study, IEEE ACCESS, 8, 215073-215090, 2020
  130. Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation, JOURNAL OF AFFECTIVE DISORDERS, 279, 20-30, 20210115
  131. White matter abnormalities and cognitive function in euthymic patients with bipolar disorder and major depressive disorder, BRAIN AND BEHAVIOR, 10(12), 202012
  132. Age-related white matter changes revealed by a whole-brain fiber-tracking method in bipolar disorder compared to major depressive disorder and healthy controls, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 75(2), 46-56, 202102
  133. Modulatory Effects of Prediction Accuracy on Electroencephalographic Brain Activity During Prediction, FRONTIERS IN HUMAN NEUROSCIENCE, 15, 630288, 20210225
  134. Cardiorespiratory synchronisation and systolic blood pressure correlation of peripheral arterial stiffness during endoscopic thoracic sympathectomy, SCIENTIFIC REPORTS, 11(1), 5966, 20210316
  135. The right hemisphere is important for driving-related cognitive function after stroke, NEUROSURGICAL REVIEW, 44(2), 977-985, 202104
  136. Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study, SCIENTIFIC REPORTS, 11(1), 4425, 20210224
  137. Pharmacological and Genetic Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in Murine Endotoxemia Model, SHOCK, 56(1), 142-149, 202107
  138. Controlled emotional tactile stimulation during functional magnetic resonance imaging and electroencephalography., Journal of Neuroscience Methods, 327, 108393-2020, 20200101
  139. The report of the joint WPA/CINP workgroup on the use and usefulness of antipsychotic medication in the treatment of schizophrenia., CNS Spectrums, 29, 1-5, 20200629
  140. Publisher Correction: Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants., Scientific Reports, 10, 17650, 20201014
  141. Corrigendum: the shape of water stream induces differences in P300 and Alpha oscillation., Frontiers in Human Neuroscience, 14, 587733, 20201021
  142. Brain changes associated with impaired attention function in chronic pain, BRAIN AND COGNITION, 154, 202111
  143. Modeling Heterogeneous Brain Dynamics of Depression and Melancholia Using Energy Landscape Analysis, FRONTIERS IN PSYCHIATRY, 12, 20211125
  144. Resting-state brain activity can predict target-independent aptitude in fMRI-neurofeedback training, NEUROIMAGE, 245, 20211215

Publications such as books

  1. 2002, Latent brain infarction and mood disorder. , Elsevier Science= Recent Advances in the Research of Affective Disorder in Japan, 2002, Scholarly Book, Joint work, 7
  2. 2002, Lithium and signal transduction. , Kluwer Academic Plenum Publishers= Catecholamine Research: From Molecular Insights to Clinical Medicine, 2002, Scholarly Book, Joint work, 3

Invited Lecture, Oral Presentation, Poster Presentation

  1. Usefulness of NIRS in the neurofeedback treatment for depression based on its pathophysiology, Satoshi Yokoyama, Shigeto Yamawaki, Go Okada, Yasumasa Okamoto, The 60th Annual Conference of Japanese Society for Medical andBiological Engineering, The 36th Annual Meeting of Japan Biomagnetism and Bioelectromagnetics Society, 2021/06/16, Without Invitation, Japanese
  2. Influence of vagus nerve stimulation on brain network in patients with epilepsy., Masaya Katagiri, Akira Hashizume, Kota Kagawa, Go Seyama, Akitake Okamura, Hui-Ling Chan, Tokiko Harada, Shigeto Yamawaki, Koji Iida, The 60th Annual Conference of Japanese Society for Medical andBiological Engineering, The 36th Annual Meeting of Japan Biomagnetism and Bioelectromagnetics Society, 2021/06/15, Without Invitation, Japanese
  3. Possible involvement of AKT-GSK3b signal-upregulated MEF2D protein in imipramine-enhanced the expression of astrocytic interleukin-10 under inflammatory state., Yosuke YAMAWAKI, Satomi SHIRAWACHI, Munechika TAKAISHI, Shigeto YAMAWAKI, Takashi KANEMATSU, 6th Congress of AsCNP, 2019/10/13, Without Invitation, English, Asian College of Neuropsychopharmacology, Fukuoka, Japan
  4. Social Brain & Emotional Brain~Implications for Major Depression and Its Treatment~, Yamawaki,S., Epilepsy, Brain and Mind International Conference(EBM), 2014/04/03, With Invitation, English, Brno, チェコ
  5. A view of the new nomenclature from the perspective of the drugs developed in Japan., Yamawaki,S., 29th CINP Congress, 2014/06/22, With Invitation, English, Vancouver, Canada
  6. Toward the Future of Psychiatric Diagnosis and Therapeutics: from Neuroscience to Mental Health., Yamawaki,S., 2014 Korean Neuropsychiatric Association (KNPA) Fall Meeting, 2014/10/24, With Invitation, English, Cheju Island, Korea
  7. Future of Neuropsychopharmacology: Global Perspective of CINP, Yamawaki,S., Executive Committee Meeting of AsCNP, 2015/02/07, With Invitation, English, Taipei, Taiwan
  8. Neuroimaging of supportive psychotherapy and cognitive behavioral Therapy(CBT)., Yamawaki,S., Indonesian Association of Biological Psychiatry and Psychopharmacology (IABPP) Annual Meeting, 2015/07/29, With Invitation, Japanese, Makassar, Indonesia
  9. Toward the future of psychiatric diagnosis and therapeutics: from neuroscience to mental health., Yamawaki,S., Chinese Psychiatric Association Annual Congress 2015, 2015/09/20, With Invitation, Japanese, Jinan, China
  10. Drivers visibility modulates visual attentional processing during a visual target detection task: a behavioral and fMRI study., Sasaoka,T., Okamoto,Y., Iwase,K., Yoshida,T., Michida,N., Kishi,A., Chiba,M., Machizawa,M., Kanayama,N., Makita,K., Yamawaki,S., Nouzawa,T., Neuroscience2015, 2015/07/28, Without Invitation, Japanese, Kobe, Japan
  11. Toward an Understanding of the Neurobiological Basis of Late Life Depression: Brain imaging and Blood Biomarker Study., Okada,G., Okamoto,Y., Takamura,M., Matsumoto,T., Yamawaki,S., 15th Annual meeting of the International College of Geriatric Psychoneuropharmacology, 2015/10/07, Without Invitation, Japanese, Palo Alto
  12. Altered Relationship Between Age and Default-Mode Network Regulation in Patients with Major Depressive Disorder: A Functional Brain Imaging Study., Takamura,M., Okamoto,Y., Okada,G., Toki,S., Yamamoto,T, Matsumoto,T., Yamawaki,S., 15th Annual meeting of the International College of Geriatric Psychoneuropharmacology, 2015/10/07, Without Invitation, Japanese, Palo Alto
  13. Effects of behavioral activation therapy on the neural correlates of subthreshold depression with a monetary incentive delay task., Mori,A., Okamoto,Y., Takamura,M., Okada,G., Jinnin,R., Takagaki,K., Kobayakawa,M., Machino,A., Yamawaki,S., The 45th Annual Meeting of Society for Neuroscience, 2015/10/17, Without Invitation, Japanese, Chicago, USA
  14. Personality Traits Predict Insular Activation during Anticipation of Affective Pictures: an fMRI study., Makita,K., Kanayama,N., Uyama,T., Okada,G., Sasaoka,T., Machizawa,M., Onoda,K., Yamawaki, S., The 45th Annual Meeting of the Society for Neuroscience, 2015/10/17, Without Invitation, Japanese, Chicago, USA
  15. Functional Connectivity of Striatum and SSRI Treatment in Major Depressive Disorder., Okada,G., Okamoto,Y., Takamura,M., Toki,S., Yamamoto,T., Yamawaki,S., ACNP 54th Annual Meeting, 2015/12/06, Without Invitation, Japanese, Phoenix, Hollywood, USA
  16. Neuroimaging biomarker of major depressive disorder - Based on the resting-state fMRI functional connectivity., Ichikawa,N., Okamoto,Y., Okada,G., Lisi,G., Yahata,N., Morimoto,J., Kawato, M., Matsuo,K., Yamagata,H., Watanabe,Y., Yamawaki,S., The 24th European Congress of Psychiatry., 2016/03/12, Without Invitation, Japanese, Madrid, Spain
  17. The relationship between behavioral characteristics and resting-state brain functional connectivity in subthreshold depression., Yokoyama,S., Okamoto,Y., Takagaki,K., Mori,A., Shiota,S., Okada,G., Takamura,M., Ichikawa,N., Jinnin,R., Yamawaki,S., 8th World Congress of Behavioral and Cognitive Therapies 2016, 2016/06/25, Without Invitation, English, Melbourne Convention and Exhibition Centre, Victoria, Australia
  18. Neural changes of intrinsic motivation between subthreshold depression and healthy subjects., Mori,A., Okamoto,Y., Takamura,M., Okada,G., Jinnin,R., Takagaki,K., Matsumoto,M., Matsumoto,K., Yamawaki,S., 30th CINP World Congress of Neuropsychopharmacology, 2016/07/03, Without Invitation, English, Seoul, KOREA
  19. Neuroimaging approaches to the innovative diagnosis and treatment for depression., Shigeto Yamawaki, 18th World Congress of Basic and Clinical Pharmacology, 2018/07/04, With Invitation, Japanese, ICC Kyoto


  1. 2006/10, ICGP President Award, 6th Annual Meeting of the ICGP

Social Activities

Organizing Academic Conferences, etc.

  1. 1994/11
  2. 1994/10
  3. 1999/06
  4. 2001/10
  5. 1995/10
  6. 1996/11
  7. 2006/10
  8. 2014/07, 2014/07