Shigeto Yamawaki

Last Updated :2022/06/30

Affiliations, Positions
Brain, Mind and KANSEI Sciences Reserch Center, Professor (Special Appointment)
Web Site
Other Contact Details
1-2-3,Kasumi,Minami-ku,Hiroshima, Japan
TEL : (+81)82-257-1724 FAX : (+81)
Graduated from School of Medicine, Hiroshima University, Japan in 1979. Professor and Chairman of the department of Psychiatry and Neurosciences, Hiroshima University(1990-2017) and now Special-appointed Professor and Professor Emeritus(2017-). President of the International College of Geriatric Psychoneuropharmacology (ICGP) (2006-2008), a founding President of the Asian College of Neuropsychopharmacology (AsCNP) (2008-2010), President of the International College of Neuropsychopharmacology (CINP) (2014-2016) and a chief of the Brain and Mind Science Committee of the Japan Science Council (2014-). His majors are clinical psychiatry, neurobiology and neuroimaging of depressive disorder. His recent interests are focused on the neuroimaging study on affection and KANSEI using functional MRI (fMRI) and artificial intelligence (AI) technology. He has served as a team leader of AMED Depression Brain Science Research Project and a research leader of Center of Innovation (COI), KANSEI Research Project(2013-2020).

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Psychiatric science

Research Keywords

  • Psychoimmunology
  • Treatment
  • Psychooncology
  • Psychiatric Approach
  • Pathophysiology
  • Neuroscience
  • Cancer Patients
  • Neuroleptic Malignant Syndrome
  • Depression

Research Activities

Academic Papers

  1. Does low self-esteem enhance social pain? The relationship between trait self-esteem and anterior cingulate cortex activation induced by ostracism, SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 5(4), 385-391, 201012
  2. Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: A preliminary resting-state fMRI study, PSYCHIATRY RESEARCH-NEUROIMAGING, 221(3), 246-248, 20140330
  3. Effects of dopaminergic and serotonergic drugs on ethanol-induced hypothermia, Life Sciences, 467-474, 19840401
  4. Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynaptses in rat brain, Neuropsychobiology, 19-26, 19860401
  5. Profiles of clinical efficacy and pharmacological action of zotepine, Pharmacopsychiatry, 4-7, 19870401
  7. Serotonin Affects Association of Aversive Outcomes to Past Actions, JOURNAL OF NEUROSCIENCE, 29(50), 15669-15674, 20091216
  8. Higher incidence of hysterectomy and oophorectomy in women suffering from clinical depression: Retrospective chart review, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 64(1), 95-98, 2010
  9. Sadness enhances the experience of pain via neural activation in the anterior cingulate cortex and amygdala: An fMRI study, NEUROIMAGE, 50(3), 1194-1201, 20100415
  10. Neural processing of negative word stimuli concerning body image in patients with eating disorders: An fMRI study, NEUROIMAGE, 50(3), 1333-1339, 20100415
  11. Brain activation during the perception of distorted body images in eating disorders, PSYCHIATRY RESEARCH-NEUROIMAGING, 181(3), 183-192, 20100330
  12. Psychosocial functioning in patients with treatment-resistant depression after group cognitive behavioral therapy, BMC PSYCHIATRY, 10, 20100316
  13. Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity, JOURNAL OF AFFECTIVE DISORDERS, 122(1-2), 76-85, 201004
  14. Psychological distress related to patterns of family functioning among Japanese childhood cancer survivors and their parents, PSYCHO-ONCOLOGY, 19(5), 545-552, 201005
  15. Long-Term Prognosis of Patients with Major Depression and Silent Cerebral Infarction, NEUROPSYCHOBIOLOGY, 62(3), 177-181, 2010
  16. DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression, PLOS ONE, 6(8), 20110830
  17. Alterations in the hippocampal glycinergic system in an animal model of posttraumatic stress disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 44(15), 1069-1074, 201011
  18. Epigenetic Regulation of BDNF Gene in Response to Stress, PSYCHIATRY INVESTIGATION, 7(4), 251-256, 201012
  19. Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change: A resting state functional magnetic resonance imaging study, NEUROSCIENCE RESEARCH, 69(2), 129-134, 201102
  20. Post-stroke depression and apathy: Interactions between functional recovery, lesion location, and emotional response, PSYCHOGERIATRICS, 11(1), 68-76, 201103
  21. Personality traits and the amplitude of spontaneous low-frequency oscillations during resting state, NEUROSCIENCE LETTERS, 492(2), 109-113, 20110401
  22. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 45(4), 460-468, 201104
  23. Inter-individual discount factor differences in reward prediction are topographically associated with caudate activation, EXPERIMENTAL BRAIN RESEARCH, 212(4), 593-601, 201108
  24. The Effect of Negative and Positive Emotionality on Associative Memory: An fMRI Study, PLOS ONE, 6(9), 20110914
  25. Asymmetric alternation of the hemodynamic response at the prefrontal cortex in patients with schizophrenia during electroconvulsive therapy: A near-infrared spectroscopy study, BRAIN RESEARCH, 1410, 132-140, 20110902
  26. Serum Brain-derived Neurotrophic Factor and Antidepressant-naive Major Depression After Lung Cancer Diagnosis, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 41(10), 1233-1237, 201110
  27. Neural and Personality Correlates of Individual Differences Related to the Effects of Acute Tryptophan Depletion on Future Reward Evaluation, NEUROPSYCHOBIOLOGY, 65(2), 55-64, 2012
  28. Effects of depression on reward-based decision making and variability of action in probabilistic learning, JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY, 43(4), 1088-1094, 201212
  29. Brain activation during the perception of stressful word stimuli concerning interpersonal relationships in anorexia nervosa patients with high degrees of alexithymia in an fMRI paradigm, PSYCHIATRY RESEARCH-NEUROIMAGING, 201(2), 113-119, 20120228
  30. Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene, JOURNAL OF PSYCHIATRIC RESEARCH, 46(5), 635-643, 201205
  31. Mood dysregulation and stabilization: perspectives from emotional cognitive neuroscience, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 15(5), 681-694, 201206
  32. Sadness Enhances the Experience of Pain and Affects Pain-Evoked Cortical Activities: An MEG Study, JOURNAL OF PAIN, 13(7), 628-635, 201207
  34. Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus, WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 13(6), 458-467, 201209
  35. Depressive symptoms and apathy are associated with psychomotor slowness and frontal activation, EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 262(6), 493-499, 201209
  36. Predictors of quality of life in inpatients with schizophrenia, PSYCHIATRY RESEARCH, 197(3), 199-205, 20120530
  37. Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16(2), 339-350, 201303
  38. Negative Correlation between Affective Symptoms and Prefrontal Activation during a Verbal Fluency Task: A Near-Infrared Spectroscopy Study, NEUROPSYCHOBIOLOGY, 67(2), 103-110, 2013
  39. The degree of early life stress predicts decreased medial prefrontal activations and the shift from internally to externally guided decision making: an exploratory NIRS study during resting state and self-oriented task, FRONTIERS IN HUMAN NEUROSCIENCE, 7, 20130703
  40. Vorinostat ameliorates impaired fear extinction possibly via the hippocampal NMDA-CaMKII pathway in an animal model of posttraumatic stress disorder, PSYCHOPHARMACOLOGY, 229(1), 51-62, 201309
  41. Automatic and Intentional Brain Responses during Evaluation of Face Approachability: Correlations with Trait Anxiety, NEUROPSYCHOBIOLOGY, 68(3), 156-167, 2013
  42. Yokukansan Treatment of Chronic Renal Failure Patients Receiving Hemodialysis, with Behavioral and Psychological Symptoms of Dementia: An Open-Label Study, AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 21(11), 1082-1085, 201311
  43. Cognitive behavioral therapy for depression changes medial prefrontal and ventral anterior cingulate cortex activity associated with self-referential processing, SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 9(4), 487-493, 201404
  44. Neuroanatomic pathway associated with attentional deficits after stroke, BRAIN RESEARCH, 1544, 25-32, 20140128
  45. Psychosocial functioning is correlated with activation in the anterior cingulate cortex and left lateral prefrontal cortex during a verbal fluency task in euthymic bipolar disorder: A preliminary fMRI study, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 68(3), 188-196, 201403
  46. Visual imagery while reading concrete and abstract Japanese kanji words: An fMRI study, NEUROSCIENCE RESEARCH, 79, 61-66, 201402
  47. The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression, JOURNAL OF PSYCHIATRIC RESEARCH, 53, 47-53, 201406
  48. A proposal for an updated neuropsychopharmacological nomenclature, EUROPEAN NEUROPSYCHOPHARMACOLOGY, 24(7), 1005-1014, 201407
  49. Neural Basis of Anticipatory Anxiety Reappraisals, PLOS ONE, 9(7), 20140721
  50. Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study, JOURNAL OF AFFECTIVE DISORDERS, 168, 229-235, 20141015
  51. Behavioral characteristics of subthreshold depression, JOURNAL OF AFFECTIVE DISORDERS, 168, 472-475, 20141015
  52. The dorsolateral prefrontal network is involved in pain perception in knee osteoarthritis patients, NEUROSCIENCE LETTERS, 581, 109-114, 20141003
  53. Hippocampal activation during associative encoding of word pairs and its relation to symptomatic improvement in depression: A functional and volumetric MRI study, JOURNAL OF AFFECTIVE DISORDERS, 152, 462-467, 201401
  54. Factors associated with the risk of relapse in schizophrenic patients after a response to electroconvulsive therapy: a retrospective study, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 11, 67-73, 2015
  55. Toward Probabilistic Diagnosis and Understanding of Depression Based on Functional MRI Data Analysis with Logistic Group LASSO, PLOS ONE, 10(5), e0123524, 20150501
  56. fMRI Study of Social Anxiety during Social Ostracism with and without Emotional Support, PLOS ONE, 10(5), e0127426, 20150522
  57. BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(23), E3067-E3074, 20150609
  58. The potential use of histone deacetylase inhibitors in the treatment of depression, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 64, 320-324, 20160104
  59. Do Individuals with Alcohol Dependence Show Higher Unfairness Sensitivity? The Relationship Between Impulsivity and Unfairness Sensitivity in Alcohol-Dependent Adults, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 39(10), 2016-2021, 201510
  60. Direct and indirect influences of childhood abuse on depression symptoms in patients with major depressive disorder, BMC PSYCHIATRY, 15, 20151014
  61. Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task, JOURNAL OF AFFECTIVE DISORDERS, 189, 254-262, 20160101
  62. Effectiveness of group cognitive behavioral therapy for somatoform pain disorder patients in Japan: A preliminary non-case-control study, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 69(12), 763-772, 201512
  63. A review of the current nomenclature for psychotropic agents and an introduction to the Neuroscience-based Nomenclature, EUROPEAN NEUROPSYCHOPHARMACOLOGY, 25(12), 2318-2325, 201512
  64. Changes in the regional cerebral blood flow detected by arterial spin labeling after 6-week escitalopram treatment for major depressive disorder, JOURNAL OF AFFECTIVE DISORDERS, 194, 135-143, 201604
  65. Association of thalamic hyperactivity with treatment-resistant depression and poor response in early treatment for major depression: a resting-state fMRI study using fractional amplitude of low-frequency fluctuations, TRANSLATIONAL PSYCHIATRY, 6, e754, 20160308
  66. Mechanisms of behavioral activation for late adolescents: Positive reinforcement mediate the relationship between activation and depressive symptoms from pre-treatment to post-treatment, JOURNAL OF AFFECTIVE DISORDERS, 204, 70-73, 20161101
  67. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia. Part 3: Update 2015 Management of special circumstances: Depression, Suicidality, substance use disorders and pregnancy and lactation., Journal The World Journal of Biological Psychiatry, 16(3), 142-170, 2015
  68. Altered Serum Levels of Matrix Metalloproteinase-2,-9 in Response to Electroconvulsive Therapy for Mood Disorders, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19(9), 201609
  69. Behavioral activation for late adolescents with subthreshold depression: a randomized controlled trial, EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 25(11), 1171-1182, 201611
  70. Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 13, 25-33, 2017
  71. Factors associated with relapse after a response to electroconvulsive therapy in unipolar versus bipolar depression, JOURNAL OF AFFECTIVE DISORDERS, 208, 113-119, 20170115
  72. Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices, JOURNAL OF AFFECTIVE DISORDERS, 208, 610-614, 20170115
  73. Increased amygdala reactivity following early life stress: a potential resilience enhancer role, BMC PSYCHIATRY, 17, 20170118
  74. Effects of behavioural activation on the neural basis of other perspective self-referential processing in subthreshold depression: a functional magnetic resonance imaging study, PSYCHOLOGICAL MEDICINE, 47(5), 877-888, 201704
  75. Disrupted Brain Activation and Deactivation Pattern during Semantic Verbal Fluency Task in Patients with Major Depression, NEUROPSYCHOBIOLOGY, 74(2), 69-77, 2016
  76. Subjectivity of the Anomalous Sense of Self Is Represented in Gray Matter Volume in the Brain, FRONTIERS IN HUMAN NEUROSCIENCE, 11, 20170509
  77. Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 20(4), 20170401
  78. Neuroanatomic pathways associated with monoaminergic dysregulation after stroke, INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 32(6), 633-642, 201706
  79. Regional brain functions in the resting state indicative of potential differences between depression and chronic pain, SCIENTIFIC REPORTS, 7, 20170607
  80. The neural correlates of the metacognitive function of other perspective: a multiple regression analysis study, NEUROREPORT, 28(11), 671-676, 20170802
  81. Prediction of clinical depression scores and detection of changes in whole-brain using resting-state functional MRI data with partial least squares regression, PLOS ONE, 12(7), 20170712
  82. Patients with major depressive disorder exhibit reduced reward size coding in the striatum, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 79, 317-323, 20171003
  83. Multiple co-clustering based on nonparametric mixture models with heterogeneous marginal distributions, PLOS ONE, 12(10), 20171019
  84. BDNF as a possible modulator of EEG oscillatory response at the parietal cortex during visuo-tactile integration processes using a rubber hand, NEUROSCIENCE RESEARCH, 124, 16-24, 201711
  85. Functional alterations of Postcentral gyrus Modulated by angry Facial expressions during intraoral Tactile stimuli in Patients with Burning Mouth syndrome: a Functional Magnetic resonance imaging study, FRONTIERS IN PSYCHIATRY, 8, 20171106
  86. Effects of behavioral activation on default mode network connectivity in subthreshold depression: A preliminary resting-state fMRI study, JOURNAL OF AFFECTIVE DISORDERS, 227, 156-163, 201802
  87. Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice, BRAIN RESEARCH, 1680, 13-38, 20180201
  88. Quantitative Evaluation of Pain during Electrocutaneous Stimulation using a Log-Linearized Peripheral Arterial Viscoelastic Model, SCIENTIFIC REPORTS, 8, 3091, 20180215
  89. Changes in resting-state brain networks after cognitive-behavioral therapy for chronic pain, PSYCHOLOGICAL MEDICINE, 48(7), 1148-1156, 201805
  90. Predictors of negative symptoms in the chronic phase of schizophrenia: A cross-sectional study, PSYCHIATRY RESEARCH, 262, 600-608, 201804
  91. Initial severity of major depression and efficacy of new generation antidepressants: individual participant data meta-analysis, ACTA PSYCHIATRICA SCANDINAVICA, 137(6), 450-458, 201806
  92. Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates, MOLECULAR PSYCHIATRY, 23(6), 1432-1445, 201806
  93. Affective auditory stimulus database: An expanded version of the International Affective Digitized Sounds (IADS-E), BEHAVIOR RESEARCH METHODS, 50(4), 1415-1429, 201808
  94. Effects of behavioural activation on the neural circuit related to intrinsic motivation, BJPSYCH OPEN, 4(5), 317-323, 201809
  95. Effects of behavioral activation program without psychotropic medication treatment for depression in late adolescence: case report, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 14, 2159-2164, 2018
  96. Enduring effects of a 5-week behavioral activation program for subthreshold depression among late adolescents: an exploratory randomized controlled trial, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 14, 2633-2641, 2018
  97. Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder, FRONTIERS IN PSYCHIATRY, 9, 691, 20181212
  98. Distinctive Neuroanatomical Substrates for Depression in Bipolar Disorder versus Major Depressive Disorder, CEREBRAL CORTEX, 29(1), 202-214, 201901
  99. Exploratory analyses of effect modifiers in the antidepressant treatment of major depression: Individual-participant data meta-analysis of 2803 participants in seven placebo-controlled randomized trials, JOURNAL OF AFFECTIVE DISORDERS, 250, 419-424, 20190501
  100. Development of fMRI-Compatible Steering Reaction Force Generation Unit, IEEE-ASME TRANSACTIONS ON MECHATRONICS, 24(2), 549-560, 201904
  101. Identification of depression subtypes and relevant brain regions using a data-driven approach, SCIENTIFIC REPORTS, 8, 14082, 20180920
  102. Reduced Serum and Cerebrospinal Fluid Levels of Autotaxin in Major Depressive Disorder, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 22(4), 261-269, 201904
  103. Development and validation of a prediction model for the probability of responding to placebo in antidepressant trials: a pooled analysis of individual patient data, EVIDENCE-BASED MENTAL HEALTH, 22(1), 10-16, 201902
  104. Towards objective olfactory evaluation based on peripheral arterial stiffness and heart rate variability indices., Conf Proc IEEE Eng Med Biol Soc., 2018, 5618-5623, 2018
  105. Predicting Ventral Striatal Activation During Reward Anticipation From Functional Connectivity at Rest, FRONTIERS IN HUMAN NEUROSCIENCE, 13, 289, 20190827
  106. Alcohol Use Disorders Identification Test-consumption Predicts the Risk of Excessive Alcohol Consumption After Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 51(6), 1934-1938, 2019
  107. Role of coping with negative emotions in cognitive behavioral therapy for persistent somatoform pain disorder: Is it more important than pain catastrophizing?, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 73(9), 560-565, 201909
  108. Controlled emotional tactile stimulation during functional magnetic resonance imaging and electroencephalography, JOURNAL OF NEUROSCIENCE METHODS, 327, 108393, 20191101
  109. Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice, NEUROCHEMISTRY INTERNATIONAL, 131, 104563, 201912
  110. Reliability and validity of the Children's Depression Inventory-Japanese version, PEDIATRICS INTERNATIONAL, 61(11), 1159-1167, 201911
  111. Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress, NEUROPHARMACOLOGY, 162, 107835, 20200101
  112. The Shape of Water Stream Induces Differences in P300 and Alpha Oscillation, FRONTIERS IN HUMAN NEUROSCIENCE, 13, 460, 20200120
  113. Predicting antidepressant response through early improvement of individual symptoms of depression incorporating baseline characteristics of patients: An individual patient data meta-analysis, JOURNAL OF PSYCHIATRIC RESEARCH, 125, 85-90, 202006
  114. Importance of the Habenula for Avoidance Learning Including Contextual Cues in the Human Brain: A Preliminary fMRI Study, FRONTIERS IN HUMAN NEUROSCIENCE, 14, 20200512
  115. Antidepressive effect of left dorsolateral prefrontal cortex neurofeedback in patients with major depressive disorder: A preliminary report, JOURNAL OF AFFECTIVE DISORDERS, 271, 224-227, 20200615
  116. The Shape of a Vehicle Windshield Affects Reaction Time and Brain Activity During a Target Detection Task, FRONTIERS IN HUMAN NEUROSCIENCE, 14, 183, 20200526
  117. Enhancing Multi-Center Generalization of Machine Learning-Based Depression Diagnosis From Resting-State fMRI, FRONTIERS IN PSYCHIATRY, 11, 400, 20200528
  118. Quantification of anticipation of excitement with a three-axial model of emotion with EEG, JOURNAL OF NEURAL ENGINEERING, 17(3), 036011, 20200601
  119. Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants, SCIENTIFIC REPORTS, 10(1), 3542, 20200226
  120. Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis, SCIENTIFIC REPORTS, 10(1), 16822, 20201008
  121. Lesions in the right Rolandic operculum are associated with self-rating affective and apathetic depressive symptoms for post-stroke patients, SCIENTIFIC REPORTS, 10(1), 20264, 20201120
  122. Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix, NEUROPSYCHOPHARMACOLOGY, 46(2), 442-454, 202101
  123. Relationships between motor and cognitive functions and subsequent post-stroke mood disorders revealed by machine learning analysis, SCIENTIFIC REPORTS, 10(1), 19571, 20201111
  124. Is Human Brain Activity During Driving Operations Modulated by the Viscoelastic Characteristics of a Steering Wheel?: An fMRI Study, IEEE ACCESS, 8, 215073-215090, 2020
  125. Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation, JOURNAL OF AFFECTIVE DISORDERS, 279, 20-30, 20210115
  126. White matter abnormalities and cognitive function in euthymic patients with bipolar disorder and major depressive disorder, BRAIN AND BEHAVIOR, 10(12), 202012
  127. Age-related white matter changes revealed by a whole-brain fiber-tracking method in bipolar disorder compared to major depressive disorder and healthy controls, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 75(2), 46-56, 202102
  128. Modulatory Effects of Prediction Accuracy on Electroencephalographic Brain Activity During Prediction, FRONTIERS IN HUMAN NEUROSCIENCE, 15, 630288, 20210225
  129. Cardiorespiratory synchronisation and systolic blood pressure correlation of peripheral arterial stiffness during endoscopic thoracic sympathectomy, SCIENTIFIC REPORTS, 11(1), 5966, 20210316
  130. The right hemisphere is important for driving-related cognitive function after stroke, NEUROSURGICAL REVIEW, 44(2), 977-985, 202104
  131. Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study, SCIENTIFIC REPORTS, 11(1), 4425, 20210224
  132. Pharmacological and Genetic Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in Murine Endotoxemia Model, SHOCK, 56(1), 142-149, 202107
  133. Controlled emotional tactile stimulation during functional magnetic resonance imaging and electroencephalography., Journal of Neuroscience Methods, 327, 108393-2020, 20200101
  134. The report of the joint WPA/CINP workgroup on the use and usefulness of antipsychotic medication in the treatment of schizophrenia., CNS Spectrums, 29, 1-5, 20200629
  135. Publisher Correction: Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants., Scientific Reports, 10, 17650, 20201014
  136. Corrigendum: the shape of water stream induces differences in P300 and Alpha oscillation., Frontiers in Human Neuroscience, 14, 587733, 20201021

Publications such as books

  1. 2002, Latent brain infarction and mood disorder. , Elsevier Science= Recent Advances in the Research of Affective Disorder in Japan, 2002, Scholarly Book, Joint work, 7
  2. 2002, Lithium and signal transduction. , Kluwer Academic Plenum Publishers= Catecholamine Research: From Molecular Insights to Clinical Medicine, 2002, Scholarly Book, Joint work, 3

Invited Lecture, Oral Presentation, Poster Presentation

  1. Usefulness of NIRS in the neurofeedback treatment for depression based on its pathophysiology, Satoshi Yokoyama, Shigeto Yamawaki, Go Okada, Yasumasa Okamoto, The 60th Annual Conference of Japanese Society for Medical andBiological Engineering, The 36th Annual Meeting of Japan Biomagnetism and Bioelectromagnetics Society, 2021/06/16, Without Invitation, Japanese
  2. Influence of vagus nerve stimulation on brain network in patients with epilepsy., Masaya Katagiri, Akira Hashizume, Kota Kagawa, Go Seyama, Akitake Okamura, Hui-Ling Chan, Tokiko Harada, Shigeto Yamawaki, Koji Iida, The 60th Annual Conference of Japanese Society for Medical andBiological Engineering, The 36th Annual Meeting of Japan Biomagnetism and Bioelectromagnetics Society, 2021/06/15, Without Invitation, Japanese
  3. Possible involvement of AKT-GSK3b signal-upregulated MEF2D protein in imipramine-enhanced the expression of astrocytic interleukin-10 under inflammatory state., Yosuke YAMAWAKI, Satomi SHIRAWACHI, Munechika TAKAISHI, Shigeto YAMAWAKI, Takashi KANEMATSU, 6th Congress of AsCNP, 2019/10/13, Without Invitation, English, Asian College of Neuropsychopharmacology, Fukuoka, Japan
  4. Social Brain & Emotional Brain~Implications for Major Depression and Its Treatment~, Yamawaki,S., Epilepsy, Brain and Mind International Conference(EBM), 2014/04/03, With Invitation, English, Brno, チェコ
  5. A view of the new nomenclature from the perspective of the drugs developed in Japan., Yamawaki,S., 29th CINP Congress, 2014/06/22, With Invitation, English, Vancouver, Canada
  6. Toward the Future of Psychiatric Diagnosis and Therapeutics: from Neuroscience to Mental Health., Yamawaki,S., 2014 Korean Neuropsychiatric Association (KNPA) Fall Meeting, 2014/10/24, With Invitation, English, Cheju Island, Korea
  7. Future of Neuropsychopharmacology: Global Perspective of CINP, Yamawaki,S., Executive Committee Meeting of AsCNP, 2015/02/07, With Invitation, English, Taipei, Taiwan
  8. Neuroimaging of supportive psychotherapy and cognitive behavioral Therapy(CBT)., Yamawaki,S., Indonesian Association of Biological Psychiatry and Psychopharmacology (IABPP) Annual Meeting, 2015/07/29, With Invitation, Japanese, Makassar, Indonesia
  9. Toward the future of psychiatric diagnosis and therapeutics: from neuroscience to mental health., Yamawaki,S., Chinese Psychiatric Association Annual Congress 2015, 2015/09/20, With Invitation, Japanese, Jinan, China
  10. Drivers visibility modulates visual attentional processing during a visual target detection task: a behavioral and fMRI study., Sasaoka,T., Okamoto,Y., Iwase,K., Yoshida,T., Michida,N., Kishi,A., Chiba,M., Machizawa,M., Kanayama,N., Makita,K., Yamawaki,S., Nouzawa,T., Neuroscience2015, 2015/07/28, Without Invitation, Japanese, Kobe, Japan
  11. Toward an Understanding of the Neurobiological Basis of Late Life Depression: Brain imaging and Blood Biomarker Study., Okada,G., Okamoto,Y., Takamura,M., Matsumoto,T., Yamawaki,S., 15th Annual meeting of the International College of Geriatric Psychoneuropharmacology, 2015/10/07, Without Invitation, Japanese, Palo Alto
  12. Altered Relationship Between Age and Default-Mode Network Regulation in Patients with Major Depressive Disorder: A Functional Brain Imaging Study., Takamura,M., Okamoto,Y., Okada,G., Toki,S., Yamamoto,T, Matsumoto,T., Yamawaki,S., 15th Annual meeting of the International College of Geriatric Psychoneuropharmacology, 2015/10/07, Without Invitation, Japanese, Palo Alto
  13. Effects of behavioral activation therapy on the neural correlates of subthreshold depression with a monetary incentive delay task., Mori,A., Okamoto,Y., Takamura,M., Okada,G., Jinnin,R., Takagaki,K., Kobayakawa,M., Machino,A., Yamawaki,S., The 45th Annual Meeting of Society for Neuroscience, 2015/10/17, Without Invitation, Japanese, Chicago, USA
  14. Personality Traits Predict Insular Activation during Anticipation of Affective Pictures: an fMRI study., Makita,K., Kanayama,N., Uyama,T., Okada,G., Sasaoka,T., Machizawa,M., Onoda,K., Yamawaki, S., The 45th Annual Meeting of the Society for Neuroscience, 2015/10/17, Without Invitation, Japanese, Chicago, USA
  15. Functional Connectivity of Striatum and SSRI Treatment in Major Depressive Disorder., Okada,G., Okamoto,Y., Takamura,M., Toki,S., Yamamoto,T., Yamawaki,S., ACNP 54th Annual Meeting, 2015/12/06, Without Invitation, Japanese, Phoenix, Hollywood, USA
  16. Neuroimaging biomarker of major depressive disorder - Based on the resting-state fMRI functional connectivity., Ichikawa,N., Okamoto,Y., Okada,G., Lisi,G., Yahata,N., Morimoto,J., Kawato, M., Matsuo,K., Yamagata,H., Watanabe,Y., Yamawaki,S., The 24th European Congress of Psychiatry., 2016/03/12, Without Invitation, Japanese, Madrid, Spain
  17. The relationship between behavioral characteristics and resting-state brain functional connectivity in subthreshold depression., Yokoyama,S., Okamoto,Y., Takagaki,K., Mori,A., Shiota,S., Okada,G., Takamura,M., Ichikawa,N., Jinnin,R., Yamawaki,S., 8th World Congress of Behavioral and Cognitive Therapies 2016, 2016/06/25, Without Invitation, English, Melbourne Convention and Exhibition Centre, Victoria, Australia
  18. Neural changes of intrinsic motivation between subthreshold depression and healthy subjects., Mori,A., Okamoto,Y., Takamura,M., Okada,G., Jinnin,R., Takagaki,K., Matsumoto,M., Matsumoto,K., Yamawaki,S., 30th CINP World Congress of Neuropsychopharmacology, 2016/07/03, Without Invitation, English, Seoul, KOREA
  19. Neuroimaging approaches to the innovative diagnosis and treatment for depression., Shigeto Yamawaki, 18th World Congress of Basic and Clinical Pharmacology, 2018/07/04, With Invitation, Japanese, ICC Kyoto


  1. 2006/10, ICGP President Award, 6th Annual Meeting of the ICGP

Social Activities

Organizing Academic Conferences, etc.

  1. 1994/11
  2. 1994/10
  3. 1999/06
  4. 2001/10
  5. 1995/10
  6. 1996/11
  7. 2006/10
  8. 2014/07, 2014/07