NAOTO SHIMIZU

Last Updated :2023/02/02

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
Web Site
E-mail
naotoshiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2021/04/01, Graduate School of Integrated Sciences for Life, Hiroshima University, Assistant Professor

Academic Degrees

  • University of Tsukuba
  • Kyoto University

Research Fields

  • Biology;Biological Science;Molecular biology
  • Biology;Biological Science;Cell biology
  • Biology;Basic biology;Genetics / Chromosome dynamics
  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals

Research Keywords

  • TK6 cells
  • DNA damage
  • DNA repair
  • radiation, anti-cancer drug
  • cancer

Affiliated Academic Societies

  • The Japanese Environmental Mutagen and Genome Society
  • The Japanese Radiation Research Society

Educational Activity

Course in Charge

  1. 2022, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  2. 2022, Undergraduate Education, 2Term, Advanced Biology
  3. 2022, Undergraduate Education, First Semester, Practice for Fundamental Biology I
  4. 2022, Undergraduate Education, First Semester, Practice for Fundamental Biology III
  5. 2022, Graduate Education (Master's Program) , 2Term, Topical Seminar in Life Science C
  6. 2022, Graduate Education (Master's Program) , 4Term, Topical Seminar in Life Science D
  7. 2022, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  8. 2022, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  9. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  10. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  11. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen, Cell Reports, 2023
  2. XRCC1 counteracts PARP poisons, Olaparib and Talazoparib, and a clinical alkylating agent, Temozolomide, by promoting the removal of trapped PARP1 from broken DNA, Genes to Cells, 20220223
  3. Repair pathways for radiation DNA damage under normoxic and hypoxic conditions: Assessment with a panel of repair-deficient human TK6 cells, Journal of Radiation Research, 62(6), 999-1004, 20210925
  4. ★, The MRE11 nuclease promotes homologous recombination not only in DNA double-strand break resection but also in post-resection in human TK6 cells, Genome Instability & Disease, 1, 184-196, 20200630
  5. Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells, Proceedings of the National Academy of Sciences of the United States of America (PNAS), 117(25), 14412-14420, 20200608
  6. ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair, PLOS ONE, 12(11), e0188320, 20171117
  7. ★, Distinct DNA damage spectra induced by ionizing radiation in normoxic and hypoxic cells, Radiation Research, 184(4), 442-448, 20151002

Invited Lecture, Oral Presentation, Poster Presentation

  1. Repair pathways for radiation DNA damage under normoxic and hypoxic conditions: Assessment with a panel of repair-deficient human TK6 cells, Naoto Shimizu, Hiroshi Ide, Masataka Tsuda, 2021/09/22, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. 2022, 2024
  2. 2022, 2025