Mari Ishida

Last Updated :2021/01/05

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor
E-mail
marihiroshima-u.ac.jp
Self-introduction
Mari Ishida

Basic Information

Educational Backgrounds

  • Hiroshima University, Faculty of Medicine, Japan, 1981/04, 1987/03
  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1991/04, 1994/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Educational Activity

  • 【Bachelor Degree Program】School of Medicine : Program of Medicine
  • 【Master's Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Cardiovascular medicine

Research Keywords

  • Pathophysiology Analysis of Cardiovascular Disease
  • vascular smooth muscle cells
  • cardiovascular disease
  • repair
  • hypertrophy
  • senescence
  • angiotensin II
  • DNA damage

Affiliated Academic Societies

  • The Physiological Society of Japan
  • American Heart Association
  • The Japanese Society of Internal Medicine
  • Japan Atherosclerosis Society
  • The Japanese Circulation society
  • The Japanese Society of Hypertension
  • The Japan Geriatrics Society
  • Japanese college of angiology
  • Japanese vascular biology and medicine organization
  • Japan Society for Medical Education

Educational Activity

Course in Charge

  1. 2020, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry
  2. 2020, Graduate Education (Master's Program) , 1Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance A
  3. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cardiovascular Physiology and Medicine
  4. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cardiovascular Physiology and Medicine
  5. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cardiovascular Physiology and Medicine
  6. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cardiovascular Physiology and Medicine

Research Activities

Academic Papers

  1. Recommendations for Maintaining the Cardiovascular Care System Under the Conditions of the COVID-19 Pandemic - 1st Edition, April 2020, Circ J, 84(11), 2023-2026, 20200925
  2. Two-Year Experience in "Tweeting the Meeting" During the Scientific Sessions - Rapid Report From the Japanese Circulation Society –, Circ Rep, 2, 691-694, 20200901
  3. Disruption of Osteoprotegerin has complex effects on medial destruction and adventitial fibrosis during mouse abdominal aortic aneurysm formation, PLOS ONE, 15(7), 20200702
  4. Coronavirus Disease 2019 (COVID-19) Information for Cardiologists -Systematic Literature Review and Additional Analysis-, CIRCULATION JOURNAL, 84(6), 1039-1043, 20200525
  5. ★, Biological Effects of Low-Dose Chest CT on Chromosomal DNA, RADIOLOGY, 295(2), 439-445, 202005
  6. DNA Damage and Senescence-Associated Inflammation in Cardiovascular Disease, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(4), 531-537, 201904
  7. Genetic Prediction of Atherosclerosis - Significance of Polymorphisms in Bone Morphogenetic Protein Signaling Molecule Genes., Circ J, 83(4), 709-710, 20190325
  8. Potential Role of Twitter at annual Congress in Japan -Narrative Literature Review of "Tweet the Meeting"-, Circ Rep, 1, 401-404, 201901
  9. JSH Statement: Asahikawa declaration in promotion of diversity by the Japanese society of hypertension-the JSH Asahikawa declaration., Hypertens Res, 42, 1483-1484, 201901
  10. Elevated Plasma Renin Activity Caused by Accelerated-malignant Hypertension in a Patient with Aldosterone-producing Adenoma Complicated with Renal Insufficiency, INTERNAL MEDICINE, 58(21), 3107-3111, 2019
  11. Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure, RADIATION RESEARCH, 190(4), 424-432, 20181001
  12. XRCC3 polymorphism is associated with hypertension-induced left ventricular hypertrophy, HYPERTENSION RESEARCH, 41(6), 426-434, 20180601
  13. Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells, PLos One, 12(11), e0187934, 201711
  14. DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters, EUROPEAN RADIOLOGY, 27(4), 1660-1666, 201704
  15. EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4, PLOS ONE, 11(10), 20161020
  16. DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters., Eur Radiol., doi:10.1007/s00330-016-4519-8, 1-7, 201608
  17. Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms, PLOS ONE, 11(1), 20160119
  18. Smoking Cessation Reverses DNA Double-Strand Breaks in Human Mononuclear Cells, PLOS ONE, 9(8), 20140805
  19. Role of DNA Damage in Cardiovascular Disease, CIRCULATION JOURNAL, 78(1), 42-50, 201401
  20. The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction., Nucleic Acids Res., 37(12), 3959-3968, 20090701
  21. Nifedipine interferes with migration of vascular smooth muscle cells via inhibition of Pyk2-Src axis., J Atheroscler Thromb, 16(3), 230-238, 20090601
  22. Angiotensin II-induced Osteopontin Expression in Vascular Smooth Muscle Cells Involves Gq/11, Ras, ERK, Src and Ets-1., Hypertension Research, 31(5), 987-998, 20080501
  23. Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells., Nucleic Acids Res., 34, 880-92, 20060401
  24. Haploinsufficiency of Rad51B Causes Centrosome Fragmentation and Aneuploidy in Human Cells., Cancer Res., 66, 20060401
  25. Beneficial effect of T-type calcium channel blockers on endotheial function in patients with essential hypertension., Hypertens Res, 28(11), 889-894, 20051101
  26. Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells., Cardiovascular Research, 68(2), 289-298, 20051101
  27. ★, XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells., EMBO J., 23, 670-80, 20040401
  28. Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation., J Am Coll Cardiol, 43, 818-25, 20040401
  29. ★, Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells., Circulation Research, 93(12), 1218-24, 20031212
  30. Effect of amlodipine and cilazapril treatment on platelet Ca2+ handling in spontaneously hypertensive rats., Hypertens. Res., 26, 901-6, 20030401
  31. Apoptosis is not increased in myocardium overexpressing type 2 angiotensin II receptor in transgenic mice, HYPERTENSION, 37(6), 1394-1398, 20010601
  32. The third cytoplasmic loop of the angiotensin II type 1 receptor exerts differential effects on extracellular signal-regulated kinase (ERK1/ERK2) and apoptosis via Ras- and Rap1-dependent pathways., Circ Res, 86(7), 729-36, 20000401
  33. Angiotensin II induces transactivation of two different populations of the platelet-derived growth factor beta receptor. Key role for the p66 adaptor protein Shc., J. Biol. Chem., 275(21), 15926-32, 20000401
  34. Shear stress-mediated extracellular signal-regulated kinase activation is regulated by sodium in endothelial cells. Potential role for a voltage-dependent sodium channel., J. Biol. Chem., 274(29), 20144-50, 19990716
  35. Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src., J. Clin. Invest., 103(6), 789-97, 19990301
  36. Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK., Circ Res, 82(12), 1272-8, 19980629
  37. p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2., Circ Res, 83(8), 824-31, 19980401
  38. Activation of extracellular signal-regulated kinases (ERK1/2) by angiotensin II is dependent on c-Src in vascular smooth muscle cells., Circ Res, 82(1), 7-12, 19980109
  39. Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma-associated proteins. Characterization of a c-Src-dependent 97-kD protein in vascular smooth muscle cells., Circ Res, 81(4), 550-7, 19970401
  40. c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1., J. Biol. Chem., 272(33), 20389-94, 19970401
  41. Angiotensin II signal transduction in vascular smooth muscle cells: role of tyrosine kinases, Keio J. Med., 46(2), 61-8, 19970401
  42. Modulation of target tissue response to angiotensin and sodium sensitivity in Japanese patients with essential hypertension, Hypertension Research, 19(3), 141-145, 19960901
  43. Effects of insulin on calcium metabolism and platelet aggregation., Hypertension, 28(2), 209-212, 19960801
  44. Platelet Ca2+ is not increased in stroke-prone spontaneously hypertensive rats : comparative study with spontaneously hypertensive rats, Hypertension, 27(6), 1312-1317, 19960601
  45. Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension., Hypertension, 27, 569-572, 19960301
  46. Angiotensin II activates pp60c-src in vascular smooth muscle cells., Circ Res, 77(6), 1053-9, 19951201
  47. Dietary salt decreases cytosolic calcium in platelets from Dahl salt-sensitive rats., American Journal of Physiology, 269, R1225-R1229, 19951101
  48. Effects of age and sex on sodium chloride sensitivity:association with plasma renin activity., Clinical Nephrology, 42(6), 376-380, 19941201
  49. Lack of increase in platelet Ca2+ and Na+ in deoxycorticosterone acetate-salt hypertensive rats., Am. J. Physiol., 267, R1288-93, 19940401
  50. Role of intracellular sodium concentration and autonomic nervous systems in blood pressure requlation., Hypertension Research, 17, 17-22, 19940401
  51. Lack of effect of ouabain on calcium homeostasis in rat platelets:comparative study with human platelets., American Journal of Physiology, 266, R651-R657, 19940301
  52. Erythrocyte sodium cannot predict hypotensive effects of calcium channel blockers., Japanese Journal of Nephrology, 35(11), 1227-1231, 19931101
  53. Na+ - Ca2+ exchange modulates Ca2+ handling of human platelets by altering intracellular Ca2+ store size., Journal of Hypertension, 11(10), 1089-1095, 19931001
  54. Primary Aldosteronism with ipsilateral adrenal cyst: report of a case., Endocrine Journal, 40(5), 619-624, 19931001
  55. Platelet calcium handling in spontaneously hypertensive rats and in three strains of normotensive rats., Journal of Hypertension, 11(5), 509-514, 19930501
  56. Familial influence upon NaCl sensitivity in patients with essential hypertension., Journal of Hypertension, 10(9), 1089-1094, 19920901
  57. Time-course of changes in intracellular cations and blood pressure with salt loading in patients with essential hypertension, Journal of Hypertension, 9(6), S302-S303, 19911201
  58. Role of intracellular cation abnormalities in development of left ventricular hypertrophy., Journal of Cardiovascular Pharmacology, 17(S2), S107-S109, 19910201

Invited Lecture, Oral Presentation, Poster Presentation

  1. Cigarette smoke extract induces the release of nuclear and mitochondrial DNA into the cytosol and chronic inflammation via activation of the cGAS-STING pathway., Ueda K, Ishida M, Sakai C, Yoshizumi M, Ishida T, 2020/12/03, Without Invitation, Japanese
  2. Role of XRCC3 polymorphism in hypertension-induced left ventricular hypertrophy, Sakai C, Ishida M, Tashiro S, Yoshizumi M, Ishida T, 2020/12/02, Without Invitation, Japanese
  3. Role of Impaired DNA Damage Response in the Initiation and Progression of Atherosclerosis., Sakai C, Ishida M, Tashiro S, Yoshizumi M, Ishida T, The 84th Annual Scientific Meeting of the Japanese Circulation Society, 2020/07/27, Without Invitation, English
  4. Influence of Different Iodinated Contrast Material on the Induction of DNA Damage by Cardiac CT., Sakane H, Fukumoto W, Sakai C, Ishida M, Tashiro S, Awai K., RSNA 2019, 2019/12/01, Without Invitation, English
  5. Assessment of DNA damage Induced by Different Tube Voltage CT Scan Using gH2AX Focus Assay, Sakane H, Fukumoto W, Sakai C, Ishida M, Tashiro S, Awai K., RSNA 2019, 2019/12/01, Without Invitation, English
  6. Omega-3 fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells, 坂井千恵美、石田万里、吉栖正生、石田隆史, 2018/12/14, Without Invitation, Japanese
  7. DNA damage in peripheral blood lymphocytes Induced by low-dose chest CT: Comparison with standard dose chest CT., H. Sakane, C. Sakai, M. Ishida, W. Fukumoto, S. Tashiro, K. Awai., RSNA 2018, 2018/11/25, Without Invitation, English
  8. DNA damage and inflammatory cytokine expression induced by radiation exposure from cardiac catheterization-an analysis in patients and operators., Yuichiro Jin, Takafumi Ishida, Shunsuke Watanabe, Lin Shi, Chiemi Sakai, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Mari Ishida, Satoshi Tashiro, Yasuchika Takeishi, American Heart Association, Scientific Session 2018., 2018/11/10, Without Invitation, English
  9. Radiation sensitivity of patients with the past history of lung cancer, 2018/04/15, Without Invitation, Japanese
  10. Role of XRCC3 in cardiac hypertrophy., Chiemi Sakai, Mari Ishida, Andi Ariyandy, Takamasa Mizuta, Kiyoshi Miyagawa, Satoshi Tashiro, Masao Yoshizumi, Takafumi Ishida, The 1st JCS Council Forum on Basic Cardiovascular Reserch, 2018/01/06, Without Invitation, English
  11. Role of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)-osteoprotegerin (OPG) axis in the development of abdominal aortic aneurysm, Bumdelger Batmunkh, Hiroki Kokubo, Ryo Kamata, Masayuki Fujii, Takafumi Ishida, Mari Ishida, Koichi Yoshimura, Masao Yoshizumi, 2017/07/06, Without Invitation, English
  12. XRCC3 polymorphism is associated with hypertension-induced left ventricular hypertrophy., Chiemi Sakai, Mari Ishida, Andi Ariyandy, Takamasa Mizuta, Keitaro Ueda, Masao Yoshizumi , Takafumi Ishida, 2017/03/17, Without Invitation, English
  13. XRCC3 Polymorphism and hypertension-induced left ventricle hypertrophy., Andi Ariyandy, Chiemi Sakai, Mari Ishida, Masao Yoshizumi, Satoshi Tashiro, Kiyoshi Miyagawa and Takafumi Ishida., The 1st International Symposium of the network-type Joint Usage/Research Center for Radiation Disaster Medical Science, 2017/02/22, Without Invitation, English
  14. 22. DNA Double-strand Breaks in Blood Lymphocytes of Patients Undergoing Coronary CT: Comparison with the Physical CT Radiation Exposure Index., Wataru Fukumoto, | Mari Ishida | Satoshi Tashiro | Kenji Kajiwara, | Makoto Iida, | Kazuo Awai, MD | Chikako Fujioka, RT | Masao Kiguchi, RT, RSNA2015, 2015/12/02, Without Invitation, English
  15. Fish oils, eicosapentaenoic acid and docosahexaenoic acid, attenuate oxidative stress-induced DNA damage in vascular endothelial cells., Chiemi Sakai, Mari Ishida, Yasuki Kihara, MasaoYoshizumi, Takafumi Ishida, ESC Congress 2015, 2015/08/30, Without Invitation, English
  16. Smoking and DNA Damage., Mari Ishida, Takafumi Ishida, Yasuki Kihara, Masao Yoshizumi, The 78th Annual Scientific Meeting of the Japanese Circulation Society, 2014/03/22, Without Invitation, Japanese
  17. The effect of ezetimibe on lipid and glucose metabolism in patients with hypercholesteromia., 2013, Without Invitation, Japanese
  18. Eicosapentaenoic Acid Rreduces Formation of Abdominal Aortic Aneurysm in Osteoprotegerin Knock Out Mice., Bumdelger Batmunkh, Mari Ishida, Masayuki Fujii, Chiemi Sakai, Takafumi Ishida, Masao Yoshizumi, The 76th Annual Scientific Meeting of the Japanese Circulation Society, 2012, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. 2019