Last Updated :2020/11/02

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Kidney internal medicine

Educational Activity

Course in Charge

  1. 2020, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2020, Undergraduate Education, Intensive, Practice for medical research

Research Activities

Academic Papers

  1. Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-beta 1 signaling, KIDNEY INTERNATIONAL, 84(2), 297-307, 201308
  2. ★, Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27(1), 203-215, 201601
  3. ★, Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression, KIDNEY INTERNATIONAL, 89(1), 147-157, 201601
  4. High glucose promotes TGF-beta 1 production by inducing FOS expression in human peritoneal mesothelial cells, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 20(1), 30-38, 201602
  5. Linagliptin Ameliorates MethylglyoxalInduced Peritoneal Fibrosis in Mice, PLOS ONE, 11(8), 20160811
  6. The Serum Lipids Levels may be Underestimated in Patients on Hemodialysis, INTERNAL MEDICINE, 54(8), 887-894, 2015
  7. Efficacy of add-on therapy of aliskiren to an angiotensin II receptor blocker on renal outcomes in advanced-stage chronic kidney disease: a prospective, randomized, open-label study, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19(4), 631-638, 201508
  8. ★, Expression of age-related factors during the development of renal damage in patients with IgA nephropathy, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19(5), 830-837, 201510
  9. ★, Vascular access intervention by a nephrologist in Hiroshima, JOURNAL OF VASCULAR ACCESS, 16, S58-S61, 201511
  10. Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats, PLOS ONE, 9(4), 20140402
  11. Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients, CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9(12), 2117-2122, 201412
  12. Morning blood pressure is useful for detection of left ventricular hypertrophy in hemodialysis patients, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 16(6), 921-929, 201212
  13. Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis., PLoS One, 12(3), e0173706, 20170509
  14. ★, Klotho as a therapeutic target during the development of renal fibrosis, Contrib Nephrol, 189, 178-183, 20161212
  15. Valproic acid attenuates renal fibrosis through the induction of autophagy, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 21(5), 771-780, 201710
  16. Oral iron supplementation with sodium ferrous citrate reduces the serum intact and c-terminal fibroblast growth factor 23 levels of maintenance haemodialysis patients, NEPHROLOGY, 22(12), 947-953, 201712
  17. Diffuse large B-cell lymphoma presenting as bilateral renal infiltration leading to acute kidney injury, CEN CASE REPORTS, 6(2), 140-147, 201711
  18. Addition of Novel Biomarkers for Predicting All-Cause and Cardiovascular Mortality in Prevalent Hemodialysis Patients, THERAPEUTIC APHERESIS AND DIALYSIS, 22(1), 31-39, 201802
  19. N-terminal pro brain natriuretic peptide as a cardiac biomarker in Japanese hemodialysis patients, INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 41(3), 135-143, 201803
  20. Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis, PLOS ONE, 13(5), 20180503
  21. High-normal albuminuria and incident chronic kidney disease in a male nondiabetic population, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 22(4), 835-842, 201808
  22. Na+-Cl- cotransporter-mediated chloride uptake contributes to hypertension and renal damage in aldosterone-infused rats, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 315(2), F300-F312, 201808
  23. Dec1 and CLOCK Regulate Na+/K+-ATPase 1 Subunit Expression and Blood Pressure, HYPERTENSION, 72(3), 746-754, 201809
  24. Protective effects of peroxisome proliferator-activated receptor gamma ligand on apoptosis and hepatocyte growth factor induction in renal ischemia-reperfusion injury, TRANSPLANTATION, 84(2), 207-213, 2007
  25. Calcium channel antagonists reduce restenosis after percutaneous transluminal angioplasty of an arteriovenous fistula in hemodialysis patients, THERAPEUTIC APHERESIS AND DIALYSIS, 12(3), 232-236, 2008
  26. Activation of signal transducer and activator of transcription 3 correlates with cell proliferation and renal injury in human glomerulonephritis, NEPHROLOGY DIALYSIS TRANSPLANTATION, 23(11), 3418-3426, 2008
  27. PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta, LABORATORY INVESTIGATION, 89(1), 47-58, 2009
  28. Mizoribine Suppresses the Progression of Experimental Peritoneal Fibrosis in a Rat Model, NEPHRON EXPERIMENTAL NEPHROLOGY, 112(2), E59-E69, 2009
  29. Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction, PLOS ONE, 13(8), 2018
  30. Coronary artery calcification score and common iliac artery calcification score in non-dialysis CKD patients, NEPHROLOGY, 23(9), 837-845, 2018
  31. Comparing the 12-month patency of low- versus high-pressure dilation in failing arteriovenous fistulae: A prospective multicenter trial (YOROI study), JOURNAL OF VASCULAR ACCESS, 19(5), 477-483, 201809
  32. ★, Klotho inhibits transforming growth factor-β1 (TGF-β1) signaling and suppresses renal fibrosis and cancer metastasis in mice, Journal of Biological Chemistry, 286(10), 8655-8665, 20110311
  33. ★, Assessment of Renal Fibrosis with Diffusion-weighted MR Imaging: Study with Murine Model of Unilateral Ureteral Obstruction, Radiology, 255(3), 722-780, 2010
  34. Ultra-short echo time (UTE) MR imaging of the lung: comparison between normal and emphysematous lungs in mutant mice, J Magn Reson Imaging, 32(2), 326-333, 2010
  35. Endothelial nitric oxide synthase intron 4 polymorphism influences the progression of renal disease, Nephron, 89(2), 219-223, 2001
  36. Osteoprotegerin and bone mineral density in hemodialysis patients, Osteoporosis international, 17(6), 841-846, 20060601
  37. Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels, Bone, 34(3), 579-583, 20040301
  38. Increased serum osteoprotegerin level in older and diabetic hemodialysis patients, Therapeutic Apheresis and Dialysis, 8(4), 335-339, 20040801
  39. Studies on post-transplant dyslipidemia in kidney transplant patients, Hiroshima journal of medical sciences, 54(2), 39-45, 2005
  40. Effect of 22-oxacalcitriol on secondary hyperparathyroidism in hemodialysis patients, Internal medicine, 42(10), 955-959, 2003
  41. Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis, Clinical and experimental nephrology, 18(3), 499-506, 20140601
  42. Performance of polysulfone membrane dialyzers and dialysate flow pattern, Clinical and experimental nephrology, 10(3), 210-215, 20060901
  43. Serum‐Free Medium Enhances the Immunosuppressive and Antifibrotic Abilities of Mesenchymal Stem Cells Utilized in Experimental Renal Fibrosis, Stem cells translational medicine, 20180930
  44. ★, TGF-β1 promotes expression of fibrosis-related genes through the induction of histone variant H3. 3 and histone chaperone HIRA, Scientific reports, 8(1), 14060-14060, 20180919
  45. Tocilizumab histologically improved AA renal amyloidosis in a patient with multicentric Castleman disease: A case report, Clinical nephrology, 90(3), 232-232, 2018
  46. pH after the first session of direct hemoperfusion with polymyxin B-immobilized fibers predicts mortality in patients with sepsis and septic shock, Clinical and experimental nephrology, 20180224