Last Updated :2023/02/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Associate Professor
Web Site
Natural products are essential for our lives from ancient times. Most of the pharmaceutical products have been found from natural products such as herbs and marine organizations. I am researching to contributions of pharmaceutical product development by finding and examining the efficacy of new lead compounds. In the medicinal plant garden, we are cultivating original plants source of crude drugs that are mainly used in Kampo medicines, and I'm also currently conducting cultivation research with the aim of ensuring a stable supply of medicinal resources. Due to the global warming, it has become difficult to obtain materials such as herbs. In an effort to solve this issue I'm trying to find the way to cultivate such materials in my lab. I would like to ensure good health and well-being of every one of them in the world through my research.

Basic Information

Major Professional Backgrounds

  • 2009/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
  • 2012/04/01, 2013/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor
  • 2013/04/01, 2015/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Lecturer
  • 2015/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Associate Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Associate Professor

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Kyoto Pharmaceutical University
  • Master of Pharmaceutical Science, Kyoto Pharmaceutical University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Natural medicines

Research Keywords

  • natural product

Affiliated Academic Societies

  • The Pharmaceutical Society of Japan
  • The Japanese Society of Pharmacognosy 
  • Japanese Society for Chemical Biology
  • Japanese Society for Plant Cell and Molecular Biology
  • Medicinal Plant Cultivation Study Group

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, 4Term, Basic Kampo Medicine
  2. 2022, Undergraduate Education, Intensive, Basic Kampo Medicine
  3. 2022, Undergraduate Education, First Semester, Experiments of Pharmacognosy
  4. 2022, Graduate Education (Master's Program) , First Semester, Seminar on Crude Drug and Kampo Medicine
  5. 2022, Graduate Education (Master's Program) , Second Semester, Seminar on Crude Drug and Kampo Medicine

Research Activities

Academic Papers

  1. Megastigmane glucosides and an unusual monoterpene from the leaves of Cananga odorata var. odorata, and absolute structures of megastigmane glucosides isolated from C. odorata var. odorata and Breynia officinalis, JOURNAL OF NATURAL MEDICINES, 64(4), 460-467, 201010
  2. Three New Flavonoid Glycosides, Byzantionoside B 6 '-O-Sulfate and Xyloglucoside of (Z)-Hex-3-en-1-ol from Rueilia patula, CHEMICAL & PHARMACEUTICAL BULLETIN, 59(6), 725-729, 201106
  3. Tricalysionoside A, a Megastigmane Gentiobioside, Sulfatricalysines A-F, and Tricalysiosides X-Z, ent-Kaurane Glucosides, from the Leaves of Tricalysia dubia, CHEMICAL & PHARMACEUTICAL BULLETIN, 59(1), 72-77, 201101
  4. Medicinal plants of Thailand. II: chemical studies on the seed kernels of Entada rheedei Sprengel, JOURNAL OF NATURAL MEDICINES, 66(3), 552-557, 201207
  5. Medicinal Plants of Thailand. I Structures of Rheedeiosides A-D and cis-Entadamide A beta-D-Glucopyranoside from the Seed Kernels of Entada rheedei, CHEMICAL & PHARMACEUTICAL BULLETIN, 59(4), 466-471, 201104
  6. Dianthosaponins A-F, Triterpene Saponins, Flavonoid Glycoside, Aromatic Amide Glucoside and gamma-Pyrone Glucoside from Dianthus japonicus, CHEMICAL & PHARMACEUTICAL BULLETIN, 59(9), 1141-1148, 201109
  7. Hirtionosides A-C, gallates of megastigmane glucosides, 3-hydroxyoctanoic acid glucosides and a phenylpropanoid glucoside from the whole plants of Euphorbia hirta, JOURNAL OF NATURAL MEDICINES, 67(2), 350-358, 201304
  8. Entadosides A-D, triterpene saponins and a glucoside of the sulphur-containing amide from the kernel nuts of Entada phaseoloides (L.) Merrill, JOURNAL OF NATURAL MEDICINES, 66(2), 321-328, 201204
  9. Glucosylated Sesquiterpene Alcohols from Fraxinus griffithii, NATURAL PRODUCT COMMUNICATIONS, 7(4), 467-470, 201204
  10. Chemical constituents from the leaves of Ruellia tuberosa, CHEMISTRY OF NATURAL COMPOUNDS, 49(1), 175-176, 201303
  11. Reinvestigation of Structures of Robustasides B and C, and Isolation of (E)-2,5-Dihydroxycinnamic Acid Esters of Arbutin and Glucose from the Leaves of Grevillea robusta, CHEMICAL & PHARMACEUTICAL BULLETIN, 60(10), 1347-1350, 201210
  12. Microtropins A-I: 6 '-O-(2 '' S,3 '' R)-2 ''-Ethyl-2 '',3 ''-dihydroxybutyrates of aliphatic alcohol beta-D-glucopyranosides from the branches of Microtropis japonica, PHYTOCHEMISTRY, 87, 140-147, 201303
  13. Structures of Ryobunins A-C from the Leaves of Clethra barbinervis, CHEMICAL & PHARMACEUTICAL BULLETIN, 61(5), 581-586, 201305
  14. C-Glycosyl flavonoids and coloratane-type sesquiterpene glucosides from the water-soluble fraction of a leaf extract of a Malagasy endemic plant, Cinnamosma fragrans (Canellaceae), JOURNAL OF NATURAL MEDICINES, 67(4), 736-742, 201310
  15. Schoepfiajasmins A-H: C-Glycosyl Dihydrochalcones, Dihydrochalcone Glycoside, C-Glucosyl Flavanones, Flavanone Glycoside and Flavone Glycoside from the Branches of Schoepfia jasminodora, CHEMICAL & PHARMACEUTICAL BULLETIN, 61(11), 1136-1142, 201311
  17. Grevillosides J-Q, Arbutin Derivatives from the Leaves of Grevillea robusta and Their Melanogenesis Inhibitory Activity, CHEMICAL & PHARMACEUTICAL BULLETIN, 62(4), 364-372, 201404
  18. 3,4-seco-24-homo-28-nor-Cycloartane and drimane-type sesquiterpenes and their lactams from the EtOAc-soluble fraction of a leaf extract of Cinnamosma fragrans and their biological activity, JOURNAL OF NATURAL MEDICINES, 68(3), 513-520, 201407
  19. Taxiphyllin 6 '-O-Gallate, Actinidioionoside 6 '-O-Gallate and Myricetrin 2 ''-O-Sulfate from the Leaves of Syzygium samarangense and Their Biological Activities, CHEMICAL & PHARMACEUTICAL BULLETIN, 62(10), 1013-1018, 201410
  20. Nitrile-Containing Phenolic Glucosides from the Leaves of Glochidion acuminatum, CHEMICAL & PHARMACEUTICAL BULLETIN, 63(1), 49-53, 201501
  21. ★, Structure elucidation of secondary metabolites isolated from the leaves of Ixora undulate and their inhibitory activity toward advanced glycation end-products formation, PHYTOCHEMISTRY, 108, 189-195, 201412
  22. One new flavonoid xyloside and one new natural triterpene rhamnoside from the leaves of Syzygium grande, PHYTOCHEMISTRY LETTERS, 10, 86-90, 201412
  23. Amphipaniculosides A-D, triterpenoid glycosides, and amphipaniculoside E, an aliphatic alcohol glycoside from the leaves of Amphilophium paniculatum, PHYTOCHEMISTRY, 115, 261-268, 201507
  24. Chemical constituents from Chorisia chodatii flowers and their biological activities, MEDICINAL CHEMISTRY RESEARCH, 24(7), 2939-2949, 201507
  25. Megastigmane Glucosides and Megastigmanes from the Leaves of Meliosma lepidota ssp squamulata, CHEMICAL & PHARMACEUTICAL BULLETIN, 63(8), 608-616, 201508
  26. New cis-ent-clerodanes from Linaria japonica, PHYTOCHEMISTRY LETTERS, 14, 56-62, 201512
  27. Officinalioside, a new lignan glucoside from Borago officinalis L., NATURAL PRODUCT RESEARCH, 30(8), 967-972, 20160417
  28. Effects of Hepatoprotective Compounds from the Leaves of Lumnitzera racemosa on Acetaminophen-Induced Liver Damage in Vitro, CHEMICAL & PHARMACEUTICAL BULLETIN, 64(4), 360-365, 201604
  29. New Isolinariins C, D and E, Flavonoid Glycosides from Linaria japonica, CHEMICAL & PHARMACEUTICAL BULLETIN, 64(5), 517-521, 201605
  30. Sulfated Glucosides of an Aliphatic Alcohol and Monoterpenes, and Megastigmanes from the Leaves of Meliosma pinnata spp. arnottiana, CHEMICAL & PHARMACEUTICAL BULLETIN, 64(6), 638-643, 201606
  31. Dianthosaponins G-I, triterpene saponins, an anthranilic acid amide glucoside and a flavonoid glycoside from the aerial parts of Dianthus japonicus and their cytotoxicity, JOURNAL OF NATURAL MEDICINES, 70(4), 816-824, 201610
  32. Lignan Diesters of Canangafruticoside A from the Leaves of Cananga odorata var. odorata, CHEMICAL & PHARMACEUTICAL BULLETIN, 65(1), 97-101, 201701
  33. Chodatiionosides A and B: two new megastigmane glycosides from Chorisia chodatii leaves, JOURNAL OF NATURAL MEDICINES, 71(1), 321-328, 201701
  34. ★, The Chemical Constituents of Uninvestigated Plants in Hiroshima Prefecture, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 137(2), 215-220, 201702
  35. ★, Chemical structures of constituents from the leaves of Polyscias balfouriana, JOURNAL OF NATURAL MEDICINES, 71(3), 558-563, 201707
  36. Aliphatic Glucoside, Zanthoionic Acid and Megastigmane Glucosides: Zanthoionosides A-E from the Leaves of Zanthoxylum ailanthoides, CHEMICAL & PHARMACEUTICAL BULLETIN, 65(8), 754-761, 201708
  37. Microtropins Q-W, ent-Labdane Glucosides: Microtropiosides G-I, Ursane-Type Triterpene Diglucoside and Flavonol Glycoside from the Leaves of Microtropis japonica, CHEMICAL & PHARMACEUTICAL BULLETIN, 65(10), 930-939, 201710
  38. ★, Biological activity of Entada phaseoloides and Entada rheedei, JOURNAL OF NATURAL MEDICINES, 72(1), 12-19, 201801
  39. Phenolic compounds from the leaves of Breynia officinalis and their tyrosinase and melanogenesis inhibitory activities, JOURNAL OF NATURAL MEDICINES, 72(2), 381-389, 201803
  40. Alkylated Benzoquinones: Ardisiaquinones A-H from the Leaves of Ardisia quinquegona and Their Anti-Leishmania Activity, CHEMICAL & PHARMACEUTICAL BULLETIN, 66(7), 757-763, 201807
  41. A novel structure of exopolysaccharide produced by a plant-derived lactic acid bacterium Lactobacillus paracasei IJH-SONE68, JOURNAL OF BIOCHEMISTRY, 164(2), 87-92, 201808
  42. Nematicidal compounds of Peperomia japonica., Phytochemistry Letters, 27, 30-35, 2018
  43. Nematicidal compounds of Peperomia japonica, PHYTOCHEMISTRY LETTERS, 27, 30-35, 201810
  44. Phytoconstituents from the aerial parts of Lampranthus spectabilis, SOUTH AFRICAN JOURNAL OF BOTANY, 118, 179-182, 201809
  45. In vitro antileishmanial activity of methanolic extracts for some selected medicinal plants, PHARMACOGNOSY MAGAZINE, 15(62), 34-37, 201904
  46. Four New Flavonoids Isolated from the Aerial Parts of Cadaba rotundifolia Forssk. (Qadab), MOLECULES, 24(11), 20190601
  47. ★, Isolation of Sesquiterpene-Amino Acid Conjugates, Onopornoids A-D, and a Flavonoid Glucoside from Onopordum alexandrinum, JOURNAL OF NATURAL PRODUCTS, 82(6), 1471-1477, 201906
  48. A New Macrolactone, Racemolide Along With Seven Known Compounds With Biological Activities From Mangrove Plant, Lumnitzera racemosa, NATURAL PRODUCT COMMUNICATIONS, 14(6), 201906
  49. Lasianosides A-E: New Iridoid Glucosides from the Leaves of Lasianthus verticillatus (Lour.) Merr. and Their Antioxidant Activity, MOLECULES, 24(21), 201911
  50. Bignanoside A "A new neolignan glucoside" and bignanoside B "A new iridoid glucoside" from Bignonia binata leaves, PHYTOCHEMISTRY LETTERS, 35, 200-205, 202002
  51. Eudesmane-type sesquiterpene glycosides: sonneratiosides A-E and eudesmol beta-d-glucopyranoside from the leaves of Sonneratia alba, JOURNAL OF NATURAL MEDICINES, 74(1), 119-126, 202001
  52. Interleukin-8 Release Inhibitors Generated by Fermentation ofArtemisia princepsPampanini Herb Extract WithLactobacillus plantarumSN13T, FRONTIERS IN MICROBIOLOGY, 11, 20200603
  53. Lasianosides F-I: A New Iridoid and Three New Bis-Iridoid Glycosides from the Leaves ofLasianthus verticillatus(Lour.) Merr., MOLECULES, 25(12), 202006
  54. New Methyl Threonolactones and Pyroglutamates of Spilanthes acmella (L.) L. and Their Bone Formation Activities, MOLECULES, 25(11), 202006
  55. Firmosides A and B: two new sucrose ferulates from the aerial parts ofSilene firmaand evaluation of radical scavenging activities, JOURNAL OF NATURAL MEDICINES, 74(4), 796-803, 202009
  56. Zanthosides A-D: Four Aromatic Glucosides from the Leaves of Zanthoxylum ailanthoides, CHEMICAL & PHARMACEUTICAL BULLETIN, 68(8), 814-817, 202008
  57. Symplocosins C-P: Fourteen Triterpene Saponins from the Leaves of Symplocos cochinchinensis var. philippinensis, CHEMICAL & PHARMACEUTICAL BULLETIN, 68(11), 1090-1099, 202011
  58. Isolation of Three New Diterpenes from Dodonaea viseosa, CHEMICAL & PHARMACEUTICAL BULLETIN, 69(1), 40-47, 202101
  59. Six New Phenylpropanoid Derivatives from Chemically Converted Extract of Alpinia galanga (L.) and Their Antiparasitic Activities, MOLECULES, 26(6), 202103
  60. Ardisiatetrons A and B: tetronic acid derivatives and triterpenes from the leaves of Ardisia quinquegona and their biological activity, JOURNAL OF NATURAL MEDICINES, 75(3), 643-654, 202106
  61. Potency of bisresorcinol from Heliciopsis terminalis on skin aging: in vitro bioactivities and molecular interactions, PEERJ, 9, 20210622
  62. Anti-Oxidant and Anti-Inflammatory Substance Generated Newly in Paeoniae Radix Alba Extract Fermented with Plant-Derived Lactobacillus brevis 174A, ANTIOXIDANTS, 10(7), 202107
  63. Lactobacillus reuteri BM53-1 Produces a Compound That Inhibits Sticky Glucan Synthesis by Streptococcus mutans, MICROORGANISMS, 9(7), 202107

Invited Lecture, Oral Presentation, Poster Presentation

  1. Study of natural products chemistry based on one area of complementary and alternative medicines: traditional medicine, Sachiko Sugimoto, VIII French Japanese international bioethics conference, 2018/08/03, Without Invitation, English

Social Activities

Other Social Contributions

  1. Academic lecture, Structure elucidation of terpenoids using NMR or MS instruments in bioactive compounds, Faculty of pharmacy universitas Airlangga, 2022/12/09, 2022/12/09, Lecturer, Lecture, Graduate students