Yasuo Furukawa

Last Updated :2021/07/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
yasfuruhiroshima-u.ac.jp
Other Contact Details
"KAGAMIYAMA 1-7-1, HIGASHI-HIROSHIMA", Japan
TEL : (+81)82-424-6566 FAX : (+81)82-424-0759
Self-introduction
We are interested in the structure and function of ion channels, which are membrane proteins permitting passive ion transport across the cell membrane. Ion channels are important determinants of neuronal excitability and plasticity. Currently, we are conducting research mainly on the peptide-gated Na+ channel and the voltage-gated K+ channels.

Basic Information

Academic Degrees

  • Doctor of Philosophy, Hiroshima University
  • Master, Hiroshima University

Educational Activity

  • 【Bachelor Degree Program】School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences
  • 【Master's Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • 【Master's Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • 【Doctoral Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • 【Doctoral Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

In Charge of Primary Major Programs

  • Integrated Arts and Sciences
  • Life Sciences

Research Fields

  • Biology;Basic biology;Animal physiology / Animal behavior

Research Keywords

  • ion channel
  • synaptic plasticity
  • neuro peptide

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2021, Liberal Arts Education Program1, 1Term, Adaptation Physiology
  2. 2021, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  3. 2021, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  4. 2021, Undergraduate Education, 2Term, Introduction to Life Sciences
  5. 2021, Undergraduate Education, 2Term, Cell Biology
  6. 2021, Undergraduate Education, 3Term, Laboratory Work in Life Sciences A
  7. 2021, Undergraduate Education, 3Term, Practical Methods in Life Sciences A
  8. 2021, Undergraduate Education, 2Term, Neurophysiology
  9. 2021, Undergraduate Education, 1Term, Fundamentals of Life Science
  10. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Life and Environmental Sciences A
  11. 2021, Graduate Education (Master's Program) , 2Term, Exercises in Life and Environmental Sciences A
  12. 2021, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Life and Environmental Sciences
  13. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Life and Environmental Sciences B
  14. 2021, Graduate Education (Master's Program) , 4Term, Exercises in Life and Environmental Sciences B
  15. 2021, Graduate Education (Master's Program) , 1Term, Introduction to Integrated Arts and Sciences
  16. 2021, Graduate Education (Master's Program) , 4Term, Advanced Molecular and Cellular Neurobiology
  17. 2021, Graduate Education (Doctoral Program) , 2Term, Seminar in Integrated Arts and Scirnces II
  18. 2021, Graduate Education (Doctoral Program) , 4Term, Exercises in Integrated Life Sciences
  19. 2021, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences

Research Activities

Academic Papers

  1. Modulation of the FMRFamide-gated Na+ channel by external Ca2+, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 469(10), 1335-1347, 201710
  2. Serotonin modulates the excitatory synaptic transmission in the dentate granule cells, JOURNAL OF NEUROPHYSIOLOGY, 115(6), 2997-3007, 20160601
  3. Molecular cloning of precursors for TEP-1 and TEP-2: The GGNG peptide-related peptides of a prosobranch gastropod, Thais clavigera, PEPTIDES, 68, 72-82, 201506
  4. Systemic angiotensin II and exercise-induced neurogenesis in adult rat hippocampus, BRAIN RESEARCH, 1588, 92-103, 20141107
  5. Electrostatic charge at position 552 affects the activation and permeation of FMRFamide-gated Na+ channels, JOURNAL OF PHYSIOLOGICAL SCIENCES, 64(2), 141-150, 201403
  6. Regulatory actions of neuropeptides and peptide hormones on the reproduction of molluscs, CANADIAN JOURNAL OF ZOOLOGY-REVUE CANADIENNE DE ZOOLOGIE, 88(9), 825-845, 201009
  7. Novel excitatory neuropeptides isolated from a prosobranch gastropod, Thais clavigera: The molluscan counterpart of the annelidan GGNG peptides, PEPTIDES, 27(3), 483-492, 200603
  8. Molecular cloning and functional characterization of the Aplysia FMRFamide-gated Na+ channel, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 451(5), 646-656, 200602
  9. Neuropeptides in Aplysia: Key players for the neural regulation of physiological functions and behavior, Invertebrate Neuropeptides and Hormones: Basic Knowledge and recent advances= Transworld Research Network, 37-73, 20060401
  10. Solution structure of ADO1, a toxin extracted from the saliva of the assassin bug, Agriosphodrus dohrni, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 54(2), 195-205, 20040201
  11. Peptidergic innervation of the vasoconstrictor muscle of the abdominal aorta in Aplysia kurodai, JOURNAL OF EXPERIMENTAL BIOLOGY, 207(25), 4439-4450, 200412
  12. Distribution and function of an Aplysia cardioexcitatory peptide, NdWFamide, in pulmonate snails, PEPTIDES, 24(10), 1533-1544, 200310
  13. Cloning of Octopus cephalotocin receptor, a member of the oxytocin/vasopressin superfamily, JOURNAL OF ENDOCRINOLOGY, 179(2), 281-291, 200311
  14. PRQFVamide, a novel pentapeptide identified from the CNS and gut of Aplysia, JOURNAL OF NEUROPHYSIOLOGY, 89(6), 3114-3127, 200306
  15. Identification of a vasopressin-like immunoreactive substance in hydra, PEPTIDES, 24(1), 17-26, 200301
  16. Deamidase inactivates a D-amino acid-containing Aplysia neuropeptide, PEPTIDES, 24(1), 45-51, 200301
  17. Distribution of the Aplysia cardioexcitatory peptide, NdWFamide, in the central and peripheral nervous systems of Aplysia, CELL AND TISSUE RESEARCH, 312(1), 95-111, 200304
  18. Cloning of Octopus cephalotocin receptor, a member of the oxytocin/vasopressin superfamily, Journal of Endocrinology, 179, 281-291, 20030401
  19. Deamidase inactivates a D-amino acid-containing Aplysia neuropeptide, Peptides, 24, 45-51, 20030401
  20. Identification of a vasopression-like immunoreactive substance in hydra, Peptides, 24, 17-26, 20030401
  21. Distribution of the Aplysia cardiovascular peptide, NdWFamide, in the central and peripheral neurvous systems of Aplysia, Cell and Tissue Research, 312, 95-111, 20030401
  22. Structural and functional diversities of the Aplysia Mytilus inhibitory peptide-related peptides, PEPTIDES, 23(11), 1959-1965, 200211
  23. Aplysia cardioactive peptide (NdWFamide) enhances the L-type Ca2+ current of Aplysia ventricular myocytes, PEPTIDES, 23(11), 1991-1998, 200211
  24. The enterins inhibit the contractile activity of the anterior aorta of Aplysia kurodai, JOURNAL OF EXPERIMENTAL BIOLOGY, 205(22), 3525-3533, 200211
  25. A novel GGNG-related neuropeptide from the polychaete Perinereis vancaurica, PEPTIDES, 23(8), 1379-1390, 200208
  26. A novel tachykinin-related peptide receptor Sequence, genomic organization, and functional analysis, European Journal of Biochemistry, 269, 4238-4246, 20020401
  27. Cumulative inactivation and the pore domain in the Kv1 channels, Pflugers Arch - European Journal of Physiology, 443, 720-730, 20020401
  28. A novel GGNG-related neuropeptide from the polychaete Perinereis vancaurica, Peptides, 23, 1379-1390, 20020401
  29. The enterins: A novel family of neuropeptides isolated from the enteric nervous system and CNS of Aplysia, JOURNAL OF NEUROSCIENCE, 21(20), 8247-8261, 20011015
  30. NdWFamide: A novel excitatory peptide involved in cardiovascular regulation of Aplysia, PEPTIDES, 22(2), 183-189, 200102
  31. Novel mechanism of blocking axonal Na+ channels by three macrocyclic polyamine analogues and two spider toxins, British Journal of Pharmacology, 132, 63-72, 20010401
  32. Purification and some properties of alanine racemase from a bivalve mollusc Corbicula japonica, Journal of Experimental Zoology, 289, 1-9, 20010401
  33. Possible functions of oxytocin/vasopressin-superfamily peptides in annelids with special reference to reproduction and osmoregulation, Journal of Experimental Zoology, 284, 401-406, 19990401
  34. Localization of leech excitatory peptide, a member of the GGNG peptides, in the central nervous system of a leech (Whitmania pigra) by immunohistochemistry and in situ hybridization, Cell and Tissue Research, 297, 155-162, 19990401
  35. The Aplysia Mytilus inhibitory peptide-related peptide, Journal of Neuroscience, 19, 9618-9634, 19990401
  36. The cadherin-like protein is essential to specificity determination and cytotoxic action of the Bacillus thuringiensis insecticidal CryIAa toxin, FEBS Letters, 460, 385-390, 19990401
  37. Immunohistochemical localization of annetocin, an earthworm oxytocin-related peptide, and identification and ultrastructural characteristics of the annetocin-secretory cells in the oligochaete earthworm Eisenia foetida, Zoological Science, 15, 381-388, 19980401
  38. Immunochemical demonstration of eisenia tetradecapeptide, a bioactive peptide isolated from the gut of the earthworm Eisenia foetida, in tissues of the earthworm, Cell and Tissue Research, 288, 567-573, 19970401
  39. Comparison of accumulative inactivation between the Aplysia K+ channel (AKv1.1a) and its amino-terminal deletion mutant, Zoological Science, 14, 397-408, 19970401
  40. Characterization of binding of the annelidan myoactive peptides, GGNG peptides, to tissues of the earthworm, Eisenia foetida, Journal of Experimental Zoology, 279, 562-570, 19970401
  41. Up- and down-modulation of a cloned Aplysia K+ channel (AKv1.1a) by the activators of protein kinase C, Zoological Science, 12, 35-44, 19950401
  42. Accumulation of inactivation in a cloned transient K+ channel (AKv1.1a) of Aplysia, Journal of Neurophysiology, 74, 1248-1257, 19950401
  43. A new class of noninactivating K+ channels from Aplysia capable of contributing to the resting potential and firing patterns of neurons, Neuron, 13, 1205-1213, 19940401
  44. Overexpression of an Aplysia Shaker K+ channel gene modifies the electrical properties and synaptic efficacy of identified Aplysia neurons, Proceedings of the National Academy of Sciences of the United States of America, 89, 1133-1137, 19920401
  45. Three types of early transient potassium currents in Aplysia neurons, Journal of Neuroscience, 12, 989-1000, 19920401
  46. Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currents, Journal of Neuroscience, 11, 918-927, 19910401
  47. Regulatory actions of 5-hydroxytryptamine and some neuropeptides on the heart of the african giant snail, Achatina fulica Ferussac, Zoological Science, 7, 377-384, 19900401
  48. Dual Effects of 5-hydroxytryptamine on the heart of a pulmonate, Achatina fulica Ferussac, Comparative Biochemistry and Physiology, 89C, 327-331, 19880401
  49. Two serotonin-sensitive potassium channels in the identified heart excitatory neurone of the African giant snail, Achatina fulica Ferussac, Experientia, 44, 738-740, 19880401
  50. Modulation of ionic currents by synaptic action and 5-HT application in the identified heart excitatory neurone of the african giant snail, Achatina fulica Ferussac, Journal of Experimental Biology, 137, 319-339, 19880401
  51. Neural control of heart beat in the african giant snail, Achatina fulica Ferussac. I. Identification of the heart regulatory neurones, Journal of Experimental Biology, 129, 279-293, 19870401
  52. Neural control of heart beat in the african giant snail, Achatina fulica Ferussac. II. Interconnections among the heart regulatory neurones, Journal of Experimental Biology, 129, 295-307, 19870401
  53. Acetylcholine-induced hyperpolarization in identified neurones of the African giant snail (Achatina fulica Ferussac), Brain Research Bulletin, 374, 227-235, 19860401
  54. Neural mechanisms underlying the feeding movements of a mollusc, Rapana thomasiana, Comparative Biochemistry and Physiology, 81A, 779-786, 19850401
  55. Molecular cloning of two distinct precursor genes of NdWFamide, a D-tryptophan-containing neuropeptide of the sea hare, Aplysia kurodai, PEPTIDES, 38(2), 291-301, 2012
  56. Position 552 in a FMRFamide-gated Na[+] channel affects the gating properties and the potency of FMRFamide, Zoological science, 27(5), 440-448, 201005
  57. Structure and Physiological Action of Novel Multiple Family Peptides of Aplysia, Biophysics, 46(6), 318-323, 20061125
  58. Purifications, Physiological Functions and Localizations of Neuropeptides in a Prosobranch Gastropod, Thais clavigera, 2005, 43-46, 20060301
  59. Novel excitatory neuropeptides isolated from a prosobranch gastropod, Thais clavigera : The molluscan counterpart of the annelidan GGNG peptides, Peptides, 27(3), 483-492, 200603

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, Development of a methodology for the selective stimulation of new born granule cells in mammalian hippocampus, 2011, 2012
  2. KAKENHI, A study on the molecular mechanisms of the functions of a peptide-gated Na^+ channel, 2008, 2010
  3. KAKENHI, A study on the structure-function relationship and the physiological function of the peptide-gated sodium channel, 2006, 2007
  4. KAKENHI, Investigation on the neuropeptide system that regulates the reproductive activity of prosobranch mollusc, Thais clavigera, 2004, 2005
  5. KAKENHI, The study on functional diversification of multiple family peptides in a mollusc, Aplysia, 2001, 2002
  6. KAKENHI, A study on the inactivation of voltage-gated potassium channels., 1997, 1998
  7. KAKENHI, 1996, 1996
  8. KAKENHI, 1995, 1995
  9. KAKENHI, 1994, 1994
  10. KAKENHI, 2015, 2017
  11. KAKENHI, 2015