Yasuo Furukawa

Last Updated :2024/02/02

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
yasfuruhiroshima-u.ac.jp
Other Contact Details
"KAGAMIYAMA 1-7-1, HIGASHI-HIROSHIMA", Japan
TEL : (+81)82-424-6566 FAX : (+81)82-424-0759
Self-introduction
We are interested in the structure and function of ion channels, which are membrane proteins permitting passive ion transport across the cell membrane. Ion channels are important determinants of neuronal excitability and plasticity. Currently, we are conducting research mainly on the peptide-gated Na+ channel and the voltage-gated K+ channels.

Basic Information

Academic Degrees

  • Doctor of Philosophy, Hiroshima University
  • Master, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences : Integrated Arts and Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

In Charge of Primary Major Programs

  • Integrated Arts and Sciences
  • Life Sciences

Research Fields

  • Biology;Basic biology;Animal physiology / Animal behavior

Research Keywords

  • ion channel
  • synaptic plasticity
  • neuro peptide

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 1Term, Adaptation Physiology
  2. 2023, Undergraduate Education, 2Term, Cell Biology
  3. 2023, Undergraduate Education, 2Term, Neurophysiology
  4. 2023, Undergraduate Education, First Semester, Fundamental Laboratory Work in Biology
  5. 2023, Undergraduate Education, First Semester, Fundamental Methodology in Biology
  6. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Life and Environmental Sciences
  7. 2023, Graduate Education (Master's Program) , First Semester, Exercises in Life and Environmental Sciences A
  8. 2023, Graduate Education (Master's Program) , Second Semester, Exercises in Life and Environmental Sciences B
  9. 2023, Graduate Education (Master's Program) , 1Term, Introduction to Integrated Arts and Sciences
  10. 2023, Graduate Education (Master's Program) , 4Term, Advanced Molecular and Cellular Neurobiology
  11. 2023, Graduate Education (Doctoral Program) , 4Term, Exercises in Integrated Life Sciences
  12. 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  13. 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  14. 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  15. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  16. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  17. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Aromatic amino acids in the finger domain of the FMRFamide-gated Na+ channel are involved in the FMRFamide recognition and the activation, Pflugers Archiv - European Journal of Physiology, online, 20230420
  2. Aromatic amino acids in the finger domain of the FMRFamide-gated Na+channel are involved in the FMRFamide recognition and the activation, bioRxiv, 20230203
  3. Cloning of Octopus cephalotocin receptor, a member of the oxytocin/vasopressin superfamily, Journal of Endocrinology, 179, 281-291, 20030401
  4. Neuropeptides in Aplysia: Key players for the neural regulation of physiological functions and behavior, Invertebrate Neuropeptides and Hormones: Basic Knowledge and recent advances= Transworld Research Network, 37-73, 20060401
  5. A novel tachykinin-related peptide receptor Sequence, genomic organization, and functional analysis, European Journal of Biochemistry, 269, 4238-4246, 20020401
  6. Deamidase inactivates a D-amino acid-containing Aplysia neuropeptide, Peptides, 24, 45-51, 20030401
  7. Identification of a vasopression-like immunoreactive substance in hydra, Peptides, 24, 17-26, 20030401
  8. Distribution of the Aplysia cardiovascular peptide, NdWFamide, in the central and peripheral neurvous systems of Aplysia, Cell and Tissue Research, 312, 95-111, 20030401
  9. Neural mechanisms underlying the feeding movements of a mollusc, Rapana thomasiana, Comparative Biochemistry and Physiology, 81A, 779-786, 19850401
  10. Acetylcholine-induced hyperpolarization in identified neurones of the African giant snail (Achatina fulica Ferussac), Brain Research Bulletin, 374, 227-235, 19860401
  11. Comparison of seawater and freshwater eels for the effects of L-alanine on water transport across the intestine, Zoological Science, 4, 45-52, 19870401
  12. Dual Effects of 5-hydroxytryptamine on the heart of a pulmonate, Achatina fulica Ferussac, Comparative Biochemistry and Physiology, 89C, 327-331, 19880401
  13. Two serotonin-sensitive potassium channels in the identified heart excitatory neurone of the African giant snail, Achatina fulica Ferussac, Experientia, 44, 738-740, 19880401
  14. Regulatory actions of 5-hydroxytryptamine and some neuropeptides on the heart of the african giant snail, Achatina fulica Ferussac, Zoological Science, 7, 377-384, 19900401
  15. Neural control of heart beat in the african giant snail, Achatina fulica Ferussac. I. Identification of the heart regulatory neurones, Journal of Experimental Biology, 129, 279-293, 19870401
  16. Neural control of heart beat in the african giant snail, Achatina fulica Ferussac. II. Interconnections among the heart regulatory neurones, Journal of Experimental Biology, 129, 295-307, 19870401
  17. Modulation of ionic currents by synaptic action and 5-HT application in the identified heart excitatory neurone of the african giant snail, Achatina fulica Ferussac, Journal of Experimental Biology, 137, 319-339, 19880401
  18. Cumulative inactivation and the pore domain in the Kv1 channels, Pflugers Arch - European Journal of Physiology, 443, 720-730, 20020401
  19. A novel GGNG-related neuropeptide from the polychaete Perinereis vancaurica, Peptides, 23, 1379-1390, 20020401
  20. Possible functions of oxytocin/vasopressin-superfamily peptides in annelids with special reference to reproduction and osmoregulation, Journal of Experimental Zoology, 284, 401-406, 19990401
  21. Localization of leech excitatory peptide, a member of the GGNG peptides, in the central nervous system of a leech (Whitmania pigra) by immunohistochemistry and in situ hybridization, Cell and Tissue Research, 297, 155-162, 19990401
  22. The Aplysia Mytilus inhibitory peptide-related peptide, Journal of Neuroscience, 19, 9618-9634, 19990401
  23. The cadherin-like protein is essential to specificity determination and cytotoxic action of the Bacillus thuringiensis insecticidal CryIAa toxin, FEBS Letters, 460, 385-390, 19990401
  24. Comparative aspects of invertebrate neuropeptides, Acta Biologica Hungarica, 51(2-4), 111-132, 20000401
  25. Novel mechanism of blocking axonal Na+ channels by three macrocyclic polyamine analogues and two spider toxins, British Journal of Pharmacology, 132, 63-72, 20010401
  26. Purification and some properties of alanine racemase from a bivalve mollusc Corbicula japonica, Journal of Experimental Zoology, 289, 1-9, 20010401
  27. Overexpression of an Aplysia Shaker K+ channel gene modifies the electrical properties and synaptic efficacy of identified Aplysia neurons, Proceedings of the National Academy of Sciences of the United States of America, 89, 1133-1137, 19920401
  28. Three types of early transient potassium currents in Aplysia neurons, Journal of Neuroscience, 12, 989-1000, 19920401
  29. A new class of noninactivating K+ channels from Aplysia capable of contributing to the resting potential and firing patterns of neurons, Neuron, 13, 1205-1213, 19940401
  30. Up- and down-modulation of a cloned Aplysia K+ channel (AKv1.1a) by the activators of protein kinase C, Zoological Science, 12, 35-44, 19950401
  31. Accumulation of inactivation in a cloned transient K+ channel (AKv1.1a) of Aplysia, Journal of Neurophysiology, 74, 1248-1257, 19950401
  32. Regulation of atrial contraction in the seawater-adapted eel, Anguilla japonica, Comparative Biochemistry and Physiology, A113, 165-172, 19960401
  33. Immunochemical demonstration of eisenia tetradecapeptide, a bioactive peptide isolated from the gut of the earthworm Eisenia foetida, in tissues of the earthworm, Cell and Tissue Research, 288, 567-573, 19970401
  34. Comparison of accumulative inactivation between the Aplysia K+ channel (AKv1.1a) and its amino-terminal deletion mutant, Zoological Science, 14, 397-408, 19970401
  35. Characterization of binding of the annelidan myoactive peptides, GGNG peptides, to tissues of the earthworm, Eisenia foetida, Journal of Experimental Zoology, 279, 562-570, 19970401
  36. A novel D-amino-acid-containing peptide isolated from Aplysia heart, Biochemical and Biophysical Research Communications, 240, 354-358, 19970401
  37. Immunohistochemical localization of annetocin, an earthworm oxytocin-related peptide, and identification and ultrastructural characteristics of the annetocin-secretory cells in the oligochaete earthworm Eisenia foetida, Zoological Science, 15, 381-388, 19980401
  38. Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currents, Journal of Neuroscience, 11, 918-927, 19910401
  39. Comparative aspects of invertebrate neuropeptides., ACTA BIOLOGICA HUNGARICA, 51(2-4), 111-132, 2000
  40. Purification and some properties of alanine racemase from a bivalve mollusc Corbicula japonica, JOURNAL OF EXPERIMENTAL ZOOLOGY, 289(1), 1-9, 20010101
  41. NdWFamide: A novel excitatory peptide involved in cardiovascular regulation of Aplysia, PEPTIDES, 22(2), 183-189, 200102
  42. The enterins: A novel family of neuropeptides isolated from the enteric nervous system and CNS of Aplysia, JOURNAL OF NEUROSCIENCE, 21(20), 8247-8261, 20011015
  43. A novel GGNG-related neuropeptide from the polychaete Perinereis vancaurica, PEPTIDES, 23(8), 1379-1390, 200208
  44. Structural and functional diversities of the Aplysia Mytilus inhibitory peptide-related peptides, PEPTIDES, 23(11), 1959-1965, 200211
  45. Aplysia cardioactive peptide (NdWFamide) enhances the L-type Ca2+ current of Aplysia ventricular myocytes, PEPTIDES, 23(11), 1991-1998, 200211
  46. The enterins inhibit the contractile activity of the anterior aorta of Aplysia kurodai, JOURNAL OF EXPERIMENTAL BIOLOGY, 205(22), 3525-3533, 200211
  47. Identification of a vasopressin-like immunoreactive substance in hydra, PEPTIDES, 24(1), 17-26, 200301
  48. Deamidase inactivates a D-amino acid-containing Aplysia neuropeptide, PEPTIDES, 24(1), 45-51, 200301
  49. Distribution of the Aplysia cardioexcitatory peptide, NdWFamide, in the central and peripheral nervous systems of Aplysia, CELL AND TISSUE RESEARCH, 312(1), 95-111, 200304
  50. PRQFVamide, a novel pentapeptide identified from the CNS and gut of Aplysia, JOURNAL OF NEUROPHYSIOLOGY, 89(6), 3114-3127, 200306
  51. Cloning of Octopus cephalotocin receptor, a member of the oxytocin/vasopressin superfamily, JOURNAL OF ENDOCRINOLOGY, 179(2), 281-291, 200311
  52. Solution structure of ADO1, a toxin extracted from the saliva of the assassin bug, Agriosphodrus dohrni, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 54(2), 195-205, 20040201
  53. Distribution and function of an Aplysia cardioexcitatory peptide, NdWFamide, in pulmonate snails, PEPTIDES, 24(10), 1533-1544, 200310
  54. Peptidergic innervation of the vasoconstrictor muscle of the abdominal aorta in Aplysia kurodai, JOURNAL OF EXPERIMENTAL BIOLOGY, 207(25), 4439-4450, 200412
  55. Molecular cloning and functional characterization of the Aplysia FMRFamide-gated Na+ channel, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 451(5), 646-656, 200602
  56. Novel excitatory neuropeptides isolated from a prosobranch gastropod, Thais clavigera: The molluscan counterpart of the annelidan GGNG peptides, PEPTIDES, 27(3), 483-492, 200603
  57. Regulatory actions of neuropeptides and peptide hormones on the reproduction of molluscs, CANADIAN JOURNAL OF ZOOLOGY-REVUE CANADIENNE DE ZOOLOGIE, 88(9), 825-845, 201009
  58. Electrostatic charge at position 552 affects the activation and permeation of FMRFamide-gated Na+ channels, JOURNAL OF PHYSIOLOGICAL SCIENCES, 64(2), 141-150, 201403
  59. Systemic angiotensin II and exercise-induced neurogenesis in adult rat hippocampus, BRAIN RESEARCH, 1588, 92-103, 20141107
  60. Molecular cloning of precursors for TEP-1 and TEP-2: The GGNG peptide-related peptides of a prosobranch gastropod, Thais clavigera, PEPTIDES, 68, 72-82, 201506
  61. Position 552 in a FMRFamide-gated Na[+] channel affects the gating properties and the potency of FMRFamide, Zoological science, 27(5), 440-448, 201005
  62. Purifications, Physiological Functions and Localizations of Neuropeptides in a Prosobranch Gastropod, Thais clavigera, 2005, 43-46, 20060301
  63. Molecular cloning of two distinct precursor genes of NdWFamide, a D-tryptophan-containing neuropeptide of the sea hare, Aplysia kurodai, PEPTIDES, 38(2), 291-301, 2012
  64. Structure and Physiological Action of Novel Multiple Family Peptides of Aplysia, Biophysics, 46(6), 318-323, 20061125
  65. Serotonin modulates the excitatory synaptic transmission in the dentate granule cells, JOURNAL OF NEUROPHYSIOLOGY, 115(6), 2997-3007, 20160601
  66. Modulation of the FMRFamide-gated Na+ channel by external Ca2+, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 469(10), 1335-1347, 201710

Invited Lecture, Oral Presentation, Poster Presentation

  1. Aromatic amino acids in the finger domain of FMRFamide-gated Na+ channel and the activation of the channel, 2022/09/08, Without Invitation, Japanese
  2. Mapping the agonist binding site of the FMRFamide-gated Na+ channel, Yasuo Furukawa, Iori Tagashira, 9th Federation of the Asian and Oceanian Physiological Societies Congress, 2019/03/29, Without Invitation, English
  3. Effects of the disruption of the disulfide bonds in the extracellular domain of the FMRFamide-gated Na+ channel, Yasuo Furukawa, Iori Tagashira, 2018/03/29, Without Invitation, English
  4. External Ca2+ affects the efficacy and the desensitization of the FMRFamide-gated Na+ channel by binding to the two negative rings at the bottom of outer vestibule of the channel pore, Yasuo Furukawa, Yu Kodani, Akihiko Fujimoto, 2017/03/28, Without Invitation, English
  5. External Ca2+ affects the efficacy and the desensitization of the FMRFamide-gated Na+ channel by binding to the two negative rings at the bottom of outer vestibule of the channel pore, Yasuo Furukawa, Yu Kodani, Akihiko Fujimoto, 2017/03/28, Without Invitation, English
  6. Tandem negative rings at the bottom of outer vestibule are involved in the efficacy as well as the desensitization of the FMRFamide-gated Na+ channel, Yasuo Furukawa, Yu Kodani, Akihiko Fujimoto, 22nd International Congress of Zoology, 87th Meeting of Zoological Society of Japan, Joint Events, 2017/11/17, Without Invitation, English, Zoological Society of Japan, Okinawa, Japan
  7. Serotonin depresses the excitatory postsynaptic potentials in the dentate granuel cells, Kanako Nozaki, Reika Kubo, Yasuo Furukawa, 46th Annual Meeting of Society for Neuroscience, 2016/11/13, Without Invitation, English, Society for Neuroscience, San Diego, CA, USA
  8. The GKWamide peptide: A novel neuropeptide of a marine snail, Thais clavigera identified by screening with the antibody to a Hydra neuropeptide, LWamide., F. MORISHITA, Y. FURUKAWA, Y. KODANI, T. Uto, O. MATSUSHIMA, H. MINAKATA, T. HORIGUCHI, 2013, Without Invitation, English
  9. Voltage-dependency of FMRFamide-gated Na+ channels, Y. Furukawa, A. Fujimoto, Y. Kodani, 2015/03/15, Without Invitation, English
  10. Pharmacological analysis of the inhibitory actions of 5-HT on the excitatory transmission in the dentage granule cells, K. Nozaki, R. Kubo, Y. Tanaka, Y. Furukawa, 2015/03/21, Without Invitation, English
  11. Brain loci relating to the thirst reception in an amphibious teleost, mudskipper, S. HAMASAKI, Y. Furukawa, K. Uematsu, M. Yoshida, T. Mukuda, 45th Annual Meeting of Society for Neuroscience, 2015/10/18, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, Development of a methodology for the selective stimulation of new born granule cells in mammalian hippocampus, 2011, 2012
  2. KAKENHI, A study on the molecular mechanisms of the functions of a peptide-gated Na^+ channel, 2008, 2010
  3. KAKENHI, A study on the structure-function relationship and the physiological function of the peptide-gated sodium channel, 2006, 2007
  4. KAKENHI, Investigation on the neuropeptide system that regulates the reproductive activity of prosobranch mollusc, Thais clavigera, 2004, 2005
  5. KAKENHI, The study on functional diversification of multiple family peptides in a mollusc, Aplysia, 2001, 2002
  6. KAKENHI, Role of neurosteroids in the regulation of motivation of instinct behaviors, 2000, 2002
  7. KAKENHI, 1998, 1998
  8. KAKENHI, The study on physiological function of muitiple family peptides in a mollusc, Aplysia, 1998, 1999
  9. KAKENHI, A study on the inactivation of voltage-gated potassium channels., 1997, 1998
  10. KAKENHI, BIOSYNTHESIS AND ACTION OF NEUROSTEROIDS IN THE BRAIN, 1996, 1997
  11. KAKENHI, 1996, 1996
  12. KAKENHI, 1995, 1995
  13. KAKENHI, 1994, 1994
  14. KAKENHI, 1994, 1994
  15. KAKENHI, 2015, 2017
  16. KAKENHI, 2015
  17. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020

Social Activities

Organizing Academic Conferences, etc.

  1. 2008/12
  2. 2015/12

History as Peer Reviews of Academic Papers

  1. 2020, Current Molecular Pharmacology, Others, 2
  2. 2016, Zoological Sciecne, Others, 1
  3. 2017, Journal of Physiology, Others, 1
  4. 2019, Current Molecular Pharmacology, Others, 1