KAZUTOSHI AKIZUKI

Last Updated :2022/08/02

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
E-mail
kakizukihiroshima-u.ac.jp
Self-introduction
My research is about protein kinases and protein phosphatases, which are key molecules of intracellular signal transduction. I am also interested in the association of these enzymes and general diseases.

Basic Information

Academic Degrees

  • Kagawa University
  • Ehime University

Educational Activity

  • [Bachelor Degree Program] School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences : Integrated Arts and Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences

Affiliated Academic Societies

  • The Japanese Biochemical Society
  • The Japan Society for Bioscience, Biotechnology, and Agrochemistry

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, 2Term, Introduction to Life Sciences
  2. 2022, Undergraduate Education, 2Term, Functional Biochemistry I
  3. 2022, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  4. 2022, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  5. 2022, Undergraduate Education, 4Term, Functional Biochemistry III

Research Activities

Academic Papers

  1. ★, CaM kinase phosphatase (CaMKP/PPM1F/POPX2) is specifically inactivated through gallate-mediated protein carbonylation, Archives of Biochemistry and Biophysics, 720, 109170-109170, 20220308
  2. ★, Biochemical characterization of four splice variants of mouse Ca2+/calmodulin-dependent protein kinase Idelta, The Journal of Biochemistry, 169(4), 445-458, 20210429
  3. Dual phosphorylation of protein phosphatase PPM1H promotes dephosphorylation of Smad1 in celluloBiochemical and Biophysical Research Communications, Biochemical and Biophysical Research Communications, 530(3), 513-519, 202009
  4. ★, Autoactivation of C-terminally truncated Ca2+/calmodulin-dependent protein kinase (CaMK) Idelta via CaMK kinase-independent autophosphorylation, Archives of Biochemistry and Biophysics, 668, 29-38, 20190615
  5. ★, Facile preparation of highly active casein kinase 1 using Escherichia coli constitutively expressing lambda phosphatase, Analytical biochemistry, 549, 99-106, 20180317
  6. ★, High-performance CaMKI: A highly active and stable form of CaMKIdelta produced by high-level soluble expression in Escherichia coli, Biochemical and Biophysical Research Communications, 475(3), 277-282, 20160701

Invited Lecture, Oral Presentation, Poster Presentation

  1. Preparation of highly active and stable CaM kinase I-delta and its unique activation mechanism., Kazutoshi Akizuki, Japan-Singapore Advanced Cancer Research Online International Symposium, 2022/01/25, With Invitation, English
  2. Migration inhibition of human breast cancer cells by inhibitors for CaMKP/PPM1F, Kazutoshi Akizuki, Nao Shimoda, Tetsuo Hirano, Takeshi Yamazaki, Yasuhiro Ishihara, Takanobu Taniguchi, Noriyuki Sueyoshi, Isamu Kameshita, Toshiyuki Murai, Atsuhiko Ishida, 2021/11, Without Invitation, Japanese
  3. Establishment of a new Escherichia coli strain constitutively expressing lambda phosphatase, and application to the preparation of highly active casein kinase 1, Kazutoshi Akizuki, Taku Toyama, Masashi Yamashita, Atsuhiko Ishida, Isamu Kameshita, Noriyuki Sueyoshi, 24th IUBMB Congress and 15th FAOBMB Congress, 2018/06, Without Invitation, English, Seoul
  4. A simple method for preparing nonphosphorylated protein kinases using E. coli strain BL21(DE3, plambdaPP) which constitutively expresses lambdaPPase, Kazutoshi Akizuki, Masashi Yamashita, Atsuhiko Ishida, Isamu Kameshita, Noriyuki Sueyoshi, The 12th International Conference on Protein Phosphatase, 2016/10, Without Invitation, English, Osaka

Awards

  1. 2018/06, Travel Grant Award of the IUBMB SEOUL 2018, IUBMB

External Funds

Acceptance Results of Competitive Funds

  1. 2021, 2024

Social Activities

History as Peer Reviews of Academic Papers

  1. 2020, Oxidative Medicine and Cellular Longevity, Others, 1