TATSUO MIYAMOTO

Last Updated :2021/01/05

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Associate Professor
Web Site
E-mail
t-miyamotohiroshima-u.ac.jp

Basic Information

Educational Backgrounds

  • Kyoto University, Graduate School, Division of Medicine, Japan, 2003/04, 2007/03

Academic Degrees

  • Ph.D., Kyoto University
  • Master of Medical Science, Kyoto University

Educational Activity

  • 【Bachelor Degree Program】School of Medicine : Program of Medicine
  • 【Master's Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science

Research Fields

  • Biology;Biological Science;Cell biology
  • Medicine,dentistry, and pharmacy;Basic medicine;General anatomy (including histology / embryology)
  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals

Research Keywords

  • centrosome
  • Genomic Instability
  • Cytoskelton
  • Ciliopathy

Affiliated Academic Societies

  • The Physiological Society of Japan
  • The Japanese Biochemical Society
  • The Japanese Society for Genome Editing
  • The American Society of Human Genetics

Educational Activity

Course in Charge

  1. 2020, Graduate Education (Master's Program) , First Semester, Molecular Biology and Radiological Science
  2. 2020, Graduate Education (Master's Program) , 4Term, Advanced Molecular and Cellular Neurobiology
  3. 2020, Graduate Education (Master's Program) , OutOfTerm(1st), Basic Training of Genome Editing
  4. 2020, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science

Research Activities

Academic Papers

  1. Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation, AGING CELL, 2020
  2. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer, NATURE COMMUNICATIONS, 11(1), 2020
  3. A novel CDK-independent function of p27(Kip1) in preciliary vesicle trafficking during ciliogenesis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 527(3), 716-722, 2020
  4. ★, Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome, EMBO JOURNAL, 39(12), 20200617
  5. Applications of Genome Editing Technology in Research on Chromosome Aneuploidy Disorders, CELLS, 9(1), 2020
  6. Space Radiation Biology for "Living in Space", BIOMED RESEARCH INTERNATIONAL, 2020, 2020
  7. Familial Rhabdomyosarcoma Due to Germline Bi-allelic Variants of BUB1B, PEDIATRIC BLOOD & CANCER, 66, S69-S69, 2019
  8. Characterization of Functional Primary Cilia in Human Induced Pluripotent Stem Cell-Derived Neurons, Neurochemical Research, 44(7), 1736-1744, 2019
  9. Albatross/FBF1 contributes to both centriole duplication and centrosome separation, GENES TO CELLS, 23(12), 1023-1042, 2018
  10. Updated summary of genome editing technology in human cultured cells linked to human genetics studies, JOURNAL OF HUMAN GENETICS, 63(2), 133-143, FEB 2018
  11. Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology, JOURNAL OF RADIATION RESEARCH, 59, 2018
  12. Coordinated regulation of the dorsal-ventral and anterior-posterior patterning of Xenopus embryos by the BTB/POZ zinc finger protein Zbtb14, DEVELOPMENT GROWTH & DIFFERENTIATION, 60(3), 158-173, APR 2018
  13. PLK1-mediated phosphorylation of WDR62/MCPH2 is required for proper mitotic spindle orientation, CANCER SCIENCE, 109, 984-984, 2018
  14. ★, PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation, HUMAN MOLECULAR GENETICS, 26(22), 4429-4440, 20171115
  15. Cytoskeleton-related regulation of primary cilia shortening mediated by melanin-concentrating hormone receptor 1., General and comparative endocrinology, 2017
  16. ★, Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells., Scientific reports, 7(1), 2017
  17. Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa, MATRIX BIOLOGY, 56, 132-149, 201612
  18. Analysis of individual differences in radiosensitivity using genome editing., Ann ICRP, in press-in press, 2016
  19. Cilia play a role in breaking left-right symmetry of the sea urchin embryo, GENES TO CELLS, 21(6), 568-578, 201606
  20. Ciliopathy in PCS (MVA) syndrome., Oncotarget, 6(28), 2015
  21. ★, YAP is essential for tissue tension to ensure vertebrate 3D body shape, NATURE, 521(7551), 217-+, 20150514
  22. ★, The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation, CELL REPORTS, 10(5), 664-673, 20150210
  23. ★, TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS ( MVA) syndrome, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(4), 1461-1466, 20140128
  24. Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(27), 10915-10920, 20120703
  25. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates, HUMAN MOLECULAR GENETICS, 20(10), 2058-2070, 20110515
  26. Efficient TALEN construction and evaluation methods for human cell and animal applications, GENES TO CELLS, 18(4), 315-326, 201304
  27. Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity, SCIENTIFIC REPORTS, 3, 20131129
  28. Two unrelated patients with MRE1 1A mutations and Nijmegen breakage syndrome-like severe microcephaly, DNA REPAIR, 10(3), 314-321, 20110307
  29. In vivo imaging of tight junctions using claudin-EGFP transgenic medaka., 20110901
  30. HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development, MECHANISMS OF DEVELOPMENT, 127(3-4), 235-245, 2010
  31. Generation of transgenic medaka expressing claudin7-EGFP for imaging of tight junctions in living medaka embryos., Cell Tissue Res., 335(2), 465-471, 20090201
  32. ★, Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice., J Cell Biol., 169(3), 527-538, 2005
  33. ★, Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential., J Cell Sci, 117, 5087-5096, 2004
  34. Experimental trials for the chromosome aneuploidy correction in Down Syndrome cell lines, 93, 302-306, 2018

Awards

  1. 2019/01/28, Distinguished Researcher, Hiroshima University, Hiroshima University

External Funds

Acceptance Results of Competitive Funds

  1. Drug Discovery Support Promotion Project , 2019/01/01, 2019/03/31
  2. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2018, 2020
  3. KAKENHI(Grant-in-Aid for Scientific Research on Innovative Areas), 2018, 2019
  4. Advanced Research and Development Programs for Medical Innovation, 2015/12/01, 2019/03/31
  5. KAKENHI, 2015, 2017
  6. KAKENHI, 2015, 2016
  7. KAKENHI, 2014, 2016
  8. KAKENHI, Molecular pathology of hereditary microcephaly by the dysfunction of DNA repair, 2011, 2013
  9. KAKENHI, 2007, 2008
  10. 2017, 2019
  11. 2017, 2019
  12. 2016
  13. 2015
  14. 2015
  15. 2014
  16. 2012
  17. Identification of an extragenic mutation of BUB1B gene of PCS(MVA) syndrome using TAL effector nucleases, 2013
  18. 2012
  19. 2011
  20. 2010, 2011
  21. 2010
  22. 2010, 2011
  23. 2015, 2017
  24. KAKENHI, 2015, 2017
  25. 2014, 2016
  26. KAKENHI, 2012, 2014
  27. KAKENHI, 2012, 2014
  28. KAKENHI, 2010, 2011
  29. KAKENHI, Epigenetic dysregulation in disorder with defective ATR signaling, 2010, 2011